1. Iida A, Kuranuki A, Yamamoto R, Uchida M, Ohta M, Ichimura M, Tsuneyama K, Masaki T, Seike M, Nakamura T. Analysis of amino acid profiles of blood over time and biomarkers associated with non-alcoholic steatohepatitis in STAM mice. Experimental Animals, 2019: 68, No.4, 417-428.
2. Fukuda A, Sasao M, Asakawa E, Narita S, Hisano M, Suruga K, Ichimura M, Tsuneyama K, Tanaka K, Omagari K. Dietary fat, cholesterol, and cholic acid affect the histopathologic severity of nonalcoholic steatohepatitis in Sprague-Dawley rats. Pathology, Research and Practice 215(11): 152599, 2019.
3. Omagari K, Asakawa E, Sasao M, Narita S, Hisano M, Fukuda A, Suruga K, Ichimura M, Tsuneyama K. Age-related alterations of nonalcoholic steatohepatitis in Sprague-Dawley rats fed a high-fat and high-cholesterol diet. Journal of Nutritional Science and Vitaminology, 65, (4): 349-356, 2019.
4. Kageyama C, Igawa T, Gion Y, Iwaki N, Tabata T, Tanaka T, Kondo E, Sakai H, Tsuneyama K, Nomoto K, Noguchi H, Yoshino T, Yokota K, Sato Y. Hepatic Campylobacter jejuni infection in patients with Castleman-Kojima disease (idiopathic multicentric Castleman disease with thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly (TAFRO) syndrome). Pathology International, Vol.69, No.10, 572-579, 2019.
5. Terziroli BBP, Mieli-Vergani G, Vergani D, Vierling MJ, Adams D, Alpini G, Banales MJ, Beuers U, Björnsson E, Bowlus C, Carbone M, Chazouillères O, Dalekos G, Gottardi De A, Harada K, Hirschfield G, Invernizzi P, Jones D, Krawitt E, Lanzavecchia A, Lian ZX, Ma X, Manns M, Mavilio D, Quigley ME, Sallusto F, Shimoda S, Strazzabosco M, Swain M, Tanaka A, Trauner M, Tsuneyama K, Zigmond E, Gershwin  EM. The challenges of primary biliary cholangitis: What is new and what needs to be done.Journal of Autoimmunity, Vol.105, 2019.
6. Jia R, Oda S,  Tsuneyama K, Urano Y,  Yokoi T. Establishment of a mouse model of troglitazone-induced liver injury and analysis of its hepatotoxic mechanism. Journal of Applied Toxicology : JAT, 2019.
7. Yang F, Takeuchi T, Tsuneyama K, Yokoi T, Oda S. Experimental Evidence of Liver Injury by BSEP-Inhibiting Drugs With a Bile Salt Supplementation in Rats. Toxicological Sciences, Vol.170, No.1, 95-108, 2019.
8. Takahashi T, Ichikawa H, Morimoto Y, Tsuneyama K, Hijikata T. Inhibition of EP2/EP4 prostanoid receptor-mediated signaling suppresses IGF-1-induced proliferation of pancreatic cancer BxPC-3 cells via upregulating γ-glutamyl cyclotransferase expression.,Biochemical and Biophysical Research Communications, Vol.516, No.2, 388-396, 2019.
9. Takikawa A, Usui I, Fujisaka S, Tsuneyama K, Okabe K, Nakagawa T, Nawaz A, Kado T, Jojima T, Aso Y, Hayakawa Y, Yagi K, Tobe K. Macrophage-specific hypoxia-inducible factor-1α deletion suppresses the development of liver tumors in high-fat diet-fed obese and diabetic mice. Journal of Diabetes Investigation, Vol.10, No.6, 1411-1418, 2019.
10. Kurano M, Tsuneyama K, Morimoto Y, Nishikawa M, Yutaka Yatomi. Apolipoprotein M suppresses the phenotypes of IgA nephropathy in hyper-IgA mice.The FASEB journal, Vol.33, No.4, 5181-5195, 2019.
11. Izawa-Ishizawa Y, Imanishi M, Zamami Y, Hiroki T, Tomoko N, Morishita M, Tsuneyama K, Horinouchi Y, Kihira Y, Takechi K, Ikeda Y, Tsuchiya K,  Yoshizumi M, Tamaki T, Ishizawa K. Development of a novel aortic dissection mouse model and evaluation of drug efficacy using in-vivo assays and database analyses. Journal of Hypertension, Vol.37, No.1, 73-83, 2019.
12. Okazaki H, Satou S, Koyama K, Morizumi S, Abe S, Azuma M, Chen Y, Goto H,  Aono H, Ogawa H, Kagawa K, Nishimura H, Kawano H, Toyoda Y, Uehara H, Kouji H, Nishioka Y. The novel inhibitor PRI-724 for Wnt/β-catenin/CBP signaling ameliorates bleomycin-induced pulmonary fibrosis in mice. Experimental Lung Research, Vol.45, No.7, 188-199, 2019.
13. Koyama K, Goto H, Morizumi S, Kagawa K, Nishimura H, Satou S, Kawano H, Toyoda Y, Ogawa H, Homma S, Nishioka Y. The Tyrosine Kinase Inhibitor TAS-115 Attenuates Bleomycin-induced Lung Fibrosis in Mice. American Journal of Respiratory Cell and Molecular Biology, Vol.60, No.4, 478-487, 2019.


1. Matsubara A, Oda S, Akai S, Tsuneyama K, Yokoi T. Establishment of a drug-induced rhabdomyolysis mouse model by co-administration of ciprofloxacin and atorvastatin. Toxicol Lett. 2018 Apr 18;291:184-193. 
2. Kurano M, Tsuneyama K, Morimoto Y, Shimizu T, Jona M, Kassai H, Nakao K, Aiba A, Yatomi Y. Apolipoprotein M protects lipopolysaccharide-treated mice from death and organ injury. Thromb Haemost. 2018 in press 
3. Takahashi T, Deuschle U, Taira S, Nishida T, Fujimoto M, Hijikata T, Tsuneyama K. Tsumura-Suzuki obese diabetic mice-derived hepatic tumors closely resemble human hepatocellular carcinomas in metabolism-related genes expression and bile acid accumulation. Hepatol Int. 2018 in press 
4. Akashi M, Tajiri K, Wada A, Tsuneyama K, Kawai K, Yasumura S, Minemura M, Takahara T, Sugiyama T. A patient with non-alcoholic steatohepatitis complicated by multiple myeloma. Intern Med. 2018 in press
5. Joshita S, Yoshizawa K, Umemura T, Ohira H, Takahashi A, Harada K, Hiep NC,Tsuneyama K, Kage M, Nakano M, Kang JH, Koike K, Zeniya M, Yasunaka T, Takaki A, Torimura T, Abe M, Yokosuka O, Tanaka A, Takikawa H; Japan Autoimmune Hepatitis Study Group (JAIHSG). Clinical features of autoimmune hepatitis with acute presentation: a Japanese nationwide survey. J Gastroenterol. 2018 in press
6: Oda S, Takeuchi M, Akai S, Shirai Y, Tsuneyama K, Yokoi T. miRNA in rat liver sinusoidal endothelial cells and hepatocytes and application to circulating
biomarkers that discern pathogenesis of liver injuries. Am J Pathol. 2018 Apr;188(4):916-928. 
7: Yamashita S, Oda S, Endo H, Tsuneyama K, Yokoi T. Neutrophil depletion protects against zomepirac-induced acute kidney injury in mice. Chem Biol Interact. 2018 Jan 5;279:102-110. 
8. 常山幸一. 少ない介入で作製するメタボリックシンドローム関連疾患モデル動物のヒト病態解析への有用性. 肝臓, 2018 59(2):92-101
9.Ogawa H, Azuma M, Tsunematu T, Morimoto Y, Kondo M, Tezuka T, Nishioka Y, Tsuneyama K. Neutrophils induce smooth muscle hyperplasia via neutrophil elastase-induced FGF-2 in a mouse model of asthma with mixed inflammation.Clin Exp Allergy. 2018
10. Saijo A,  Goto H, Nakano M, Mitsuhashi A, Aono Y, Hanibuchi M, Ogawa HUehara H, Kondo K, Nishioka Y. Bone marrow-derived fibrocytes promote stem cell-like properties of lung cancer cells. Cancer Letters 2018
11. Omagari K, Fukuda A, Suga M, Ogata A, Nishioka S, Suruga K, Ichimura M, Tsuneyama K. Peptides Obtained by Enzymatic Decomposition of Mackerel Prevent Nonalcoholic Steatohepatitis in Sprague-Dawley Rats fed a High-fat and High-cholesterol Diet. OBM Hepatology and Gastroenterology 2(3), 2018.
12. Nagatomo R, Okada Y, Ichimura MTsuneyama K, Inoue K. Application of 2-Picolylamine Derivatized Ultra-high Performance Liquid Chromatography Tandem Mass Spectrometry for Determination of Short-chain Fatty Acids in Feces Samples. Analytical Sciences, 2018 34 (9)
13. Fujimoto S, Muguruma N, Okamoto K, Kurihara T, Sato Y, Miyamoto Y, Kitamura S, Miyamoto H, Taguchi T, Tsuneyama K, Takayama T. A novel theranostic combination of near-infrared fluorescence imaging and laser irradiation targeting c-KIT for gastrointestinal stromal tumors. Theranostics 2018 Mar 21;8(9):2313-2328. DOI:10.7150/thno.22027
14. Takeuchi M, Oda S, Tsuneyama K, Yokoi T. Comprehensive analysis of serum microRNAs in hepatic sinusoidal obstruction syndrome (SOS) in rats: implication as early phase biomarkers for SOS. Arch Toxicol 2018 Sep;92(9):2947-2962.DOI:10.1007/s00204-018-2269-x
15. Gao CY, Yao Y, Li L, Yang SH, Chu H, Tsuneyama K, Li XM, Gershwin ME, Lian ZX. Tissue-Resident Memory CD8+ T Cells Acting as Mediators of Salivary Gland Damage in a Murine Model of Sjögren's Syndrome. Arthritis Rheumatol. 2018 Jul 23. in press DOI:10.1002/art.40676
16. Kondo M, Ogino H, Ogawa H, Afroj T, Toyoda Y, Sakaguchi S, Tsuboi M, Bando Y, Goto H, Tsuneyama K, Nishioka Y. A case of pulmonary pleomorphic carcinoma with malignant phenotypes induced by ZEB1-associated epithelial-mesenchymal transition. Respir Med Case Rep. 2018 Aug 3;25:119-121. DOI:10.1016/j.rmcr.2018.07.008
17. Kagemoto K, Okamoto K, Takaoka T, Sato Y, Kitamura S, Kimura T, Sogabe M, Miyamoto H, Muguruma N, Tsuneyama K, Takayama T. Detection of aberrant crypt foci with image-enhanced endoscopy. Endosc Int Open 2018 Aug;6(8):E924-E933.DOI:10.1055/a-0621-8794
18. Urano Y, Oda S, Tsuneyama K, Yokoi T. Comparative hepatic transcriptome analyses revealed possible pathogenic mechanisms of fasiglifam (TAK-875)-induced acute liver injury in mice. Chem Biol Interact 2018 Dec 25;296:185-197. DOI:10.1016/j.cbi.2018.09.011 
19. Izawa-Ishizawa Y, Imanishi M, Zamami Y, Toya H, Nagao T, Morishita M,Tsuneyama K, Horinouchi Y, Kihara Y, Takechi K, Ikeda Y, Tsuchiya K, Yoshizumi M, Tamaki T, Ishizawa K. Development of a novel aortic dissection mouse model and evaluation of drug efficacy using in-vivo assays and database analyses. J Hypertens 2019 Jan; 37(1):73-83.
20. Ma HD, Zhao ZB, Ma WT, Liu QZ, Gao CY, Li L, Wang J, Tsuneyama K, Liu B, Zhang W, Zhou Y, Gershwin ME, Lian ZX. Gut microbiota translocation promotes autoimmune cholangitis. J Autoimmun 2018 Dec;95:47-57.
21. Nishitsuji K, Watanabe S, Xiao J, Nagatomo R, Ogawa H, Tsunematsu T, Umemoto H, Morimoto Y, Akatsu H, Inoue K, Tsuneyama K. Effect of coffee or coffee components on gut microbiome and short-chain fatty acids in a mouse model of metabolic syndrome. Sci Rep 2018 Nov 1;8(1):16173.
22. Morimoto J, Nishikawa Y, Kakimoto T, Furutani K, Kihara N, Matsumoto M, Tsuneyama K, Kozono Y, Kozono H, Hozumi K, Hosomichi K, Nishijima H, Matsumoto M. Aire Controls in Trans the Production of Medullary Thymic Epithelial Cells Expressing Ly-6C/Ly-6G. J Immunol 2018 Dec 1;201(11):3244-3257.
23. Moritoki Y, Tsuneyama K, Nakamura Y, Kikuchi K, Shiota A, Ohsugi Y, Lian ZX, Zhang W, Yang GX, Ueki S, Takeda M, Omokawa A, Saga T, Saga A, Watanabe D, Miura M, Ueno Y, Leung PSC, Tanaka A, Gershwin ME, Hirokawa M. Anti-drug Antibodies Against a Novel Humanized Anti-CD20 Antibody
Impair Its Therapeutic Effect on Primary Biliary Cholangitis in Human CD20- and FcγR-Expressing Mice. Front Immunol 2018 Nov 2;9:2534.
24. Omagari K, Suruga K, Kyogoku A, Nakamura S, Nakamoto A, Nishioka S, Ichimura M, Miyata Y, Tajima K, Tsuneyama K, Tanaka K. A fermented mixed tea made with camellia (Camellia japonica) and third-crop green tea leaves prevents nonalcoholic steatohepatitis in Sprague-Dawley rats fed a high-fat and high-cholesterol diet. Hepatobiliary Surg Nutr 2018 Jun; 7(3):175-184.
25. Kurano M, Tsuneyama K, Morimoto Y, Nishikawa M, Yatomi Y. Apolipoprotein M Suppresses the Phenotypes of IgA Nephropathy in Hyper-IgA mice. FASEB J, in press
26. Kishi M, Aono Y, Sato S, Koyama K, Azuma M, Abe S, Kawano H, Kishi J, Toyoda Y, Okazaki H, Ogawa H, Uehara H, Nishioka Y. Blockade of platelet-derived growth factor receptor-β, not receptor-α ameliorates bleomycin-induced pulmonary fibrosis in mice. PLOS ONE, in press.
27. Koyama K, Goto H, Morizumi S, Kagawa K, Nishimura H, Sato S, Kawano H, Toyoda Y, Ogawa H, Homma S, Nishioka Y. Novel multiple tyrosine kinase inhibitor TAS-115 attenuates bleomycin-induced lung fibrosis in mice. Am J Respir Cell Mol Biol, in press.
28. Izumi Y, Ogawa H, Uehara H, Murayama S, Sata M, Kaji R, Distinct Incidence of Takotsubo Syndrome between Amyotrophic Lateral Sclerosis and Synucleinopathies: A Cohort Study. Frontiers in Neurology in press


1. Mouri Y, Ueda Y, Yamano T, Matsumoto M, Tsuneyama K, Kinashi T, Matsumoto M.Mode of tolerance induction and requirement for aire are governed by the cell types that express self-antigen and those that present antigen. J Immunol. 2017 Dec 15;199(12):3959-3971.

2. Tsuneyama K, Nishitsuji K, Matsumoto M, Kobayashi T, Morimoto Y, Tsunematsu T, Ogawa H. Animal models for analyzing metabolic syndrome-associated liver diseases. Pathol Int. 2017 Nov;67(11):539-546.

3. Nishitsuji K, Xiao J, Nagatomo R, Umemoto H, Morimoto Y, Akatsu H, Inoue K, Tsuneyama K. Analysis of the gut microbiome and plasma short-chain fatty acid profiles in a spontaneous mouse model of metabolic syndrome. Sci Rep. 2017 Nov 20;7(1):15876.

4. Tsutsui A, Harada K, Tsuneyama K, Senoh T, Nagano T, Takaguchi K, Ando M, Nakamura S, Mizobuchi K, Kudo M. Clinicopathological study of autoimmune hepatitis cases that were difficult to differentiate from drug-induced liver injury. Dig Dis. 2017 Oct ;35(6):506-514.

5. Fujimoto Y, Tsuneyama K, Kuramoto N, Hayashi S, Yoshida N, Morioka A, Teramoto M, Nakajima H, Takeuchi T, Azuma YT. Exacerbated experimental pancreatitis in interleukin-19 knockout mice. Glob Drugs Therap. 2017 in press.

6. Tsuneyama K, Baba H, Matsumoto M, Kobayashi T, Morimoto Y, Tsunematsu T, Ogawa H. Effectiveness of new animal models for the analysis of metabolic syndrome-associated liver diseases. Patrol Int. 2017 in press

7. Nishijima H, Kajimoto T, Matsuoka Y, Mouri Y, Morimoto J, Matsumoto M, Kawano H, Nishioka Y, Uehara H, Izumi K, Tsuneyama K, Okazaki IM, Okazaki T, Hosomichi K, Shiraki A, Shibutani M, Mitsumori K, Matsumoto M. Paradoxical development of polymyositis-like autoimmunity through augmented expression of autoimmune regulator (AIRE). J Autoimmun. 2017 in press

8. Bae HR, Hodge DL, Yang GX, Leung PSC, Chodisetti SB, Valencia JC, Sanford M, Fenimore JM, Rahman ZSM, Tsuneyama K, Norman GL, Gershwin ME, Young HA. The interplay of type I and type II interferons in murine autoimmune cholangitis as a basis for sex-biased autoimmunity. Hepatology. 2017 in press

9. Baba H, Kurano M, Nishida T, Hatta H, Hokao R, Tsuneyama K. Facilitatory effect of insulin treatment on hepatocellular carcinoma development in diabetes.  BMC Res Notes. 2017 Sep 13;10(1):478.

10. Nawaz A, Aminuddin A, Kado T, Takikawa A, Yamamoto S, Tsuneyama K, Igarashi Y, Ikutani M, Nishida Y, Nagai Y, Takatsu K, Imura J, Sasahara M, Okazaki Y, Ueki K, Okamura T, Tokuyama K, Ando A, Matsumoto M, Mori H, Nakagawa T, Kobayashi N, Saeki K, Usui I, Fujisaka S, Tobe K. CD206(+) M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors. Nat Commun. 2017 Aug 18;8(1):286.

11. Matsumoto K, Ichimura M, Tsuneyama K, Moritoki Y, Tsunashima H, Omagari K, Hara M, Yasuda I, Miyakawa H, Kikuchi K. Fructo-oligosaccharides and intestinal barrier function in a methionine-choline-deficient mouse model of nonalcoholic steatohepatitis. PLoS One. 2017 Jun 20;12(6):e0175406.

12. Takeuchi M, Matsuzaki K, Tsuneyama K, Nishimura M, Takiguchi E, Harada M. Ovarian Large Cell Neuroendocrine Carcinoma Associated with Serous Carcinoma: Correlation of Pathology with MR Imaging. Magn Reson Med Sci. 2017 Oct 10;16 (4):273-274.

13. Shimada S, Tajiri K, Baba H, Minemura M, Tsuneyama K, Nakano M, Sugiyama T. Peritumoral Hyperplasia in Hepatic Sclerosed Hemangioma. ACG Case Rep J. 2017 Apr 26;4:e61.

14. Nguyen Canh H, Harada K, Ouchi H, Sato Y, Tsuneyama K, Kage M, Nakano M, Yoshizawa K, Takahashi A, Abe M, Kang JH, Koike K, Inui A, Fujisawa T, Takaki A, Arinaga-Hino T, Torimura T, Suzuki Y, Fujiwara K, Zeniya M, Ohira H, Tanaka A, Takikawa H; Intractable Liver and Biliary Diseases Study Group of Japan. Acute presentation of autoimmune hepatitis: a multicentre study with detailed histological evaluation in a large cohort of patients. J Clin Pathol. 2017 Nov;70(11):961-969.

15. Ikutani M, Tsuneyama K, Kawaguchi M, Fukuoka J, Kudo F, Nakae S, Arita M, Nagai Y, Takaki S, Takatsu K. Prolonged activation of IL-5-producing ILC2 causes  pulmonary arterial hypertrophy. JCI Insight. 2017 Apr 6;2(7):e90721.

16. Tsuneyama K, Baba H, Morimoto Y, Tsunematsu T, Ogawa H. Primary Biliary Cholangitis: Its Pathological Characteristics and Immunopathological Mechanisms.  J Med Invest. 2017;64(1.2):7-13.

17. Watanabe S, Takahashi T, Ogawa H, Uehara H, Tsunematsu T, Baba H, Morimoto Y, Tsuneyama K. Daily Coffee Intake Inhibits Pancreatic Beta Cell Damage and Nonalcoholic Steatohepatitis in a Mouse Model of Spontaneous Metabolic Syndrome,  Tsumura-Suzuki Obese Diabetic Mice. Metab Syndr Relat Disord. 2017 May;15(4):170-177.

18. Chang C, Lleo A, Kananurak A, Grizzi F, Tsuneyama K, Invernizzi P, Bevins CL, Bowlus CL. Human β-Defensin 2 in Primary Sclerosing Cholangitis. Clin Transl Gastroenterol. 2017 Mar 16;8(3):e80.

19. Shirai Y, Oda S, Makino S, Tsuneyama K, Yokoi T. Establishment of a mouse model of enalapril-induced liver injury and investigation of the pathogenesis. Lab Invest. 2017 Jul;97(7):833-842.

20. Ma HD, Ma WT, Liu QZ, Zhao ZB, Liu MZ, Tsuneyama K, Gao JM, Ridgway WM, Ansari AA, Gershwin ME, Fei YY, Lian ZX. Chemokine receptor CXCR3 deficiency exacerbates murine autoimmune cholangitis by promoting pathogenic CD8(+) T cell activation. J Autoimmun. 2017 Mar;78:19-28.

21. Ichimura M, Masuzumi M, Kawase M, Sakaki M, Tamaru S, Nagata Y, Tanaka K, Suruga K, Tsuneyama K, Matsuda S, Omagari K. A diet-induced Sprague-Dawley rat model of nonalcoholic steatohepatitis-related cirrhosis. J Nutr Biochem. 2017 Feb;40:62-69.

22. Oda S, Shirai Y, Akai S, Nakajima A, Tsuneyama K, Yokoi T. Toxicological role of an acyl glucuronide metabolite in diclofenac-induced acute liver injuly in mice. J Appl Toxicol. 2017 may;37(5):545-553.

23.  Kawashita Y, Morine Y, Ikemoto T, Saito Y, Iwahashi S, Yamada S, Higashijima J, Imura S, Ogawa H, Yagi T, Shimada M. Loss of Fbxw7 expression is a predictor of recurrence in colorectal liver metastasis. J Hepatobilliary Pancreat Sci. 2017 Aug;24:576-583.

24. Nakano AOgawa H, Nakanishi Y, Fujita H, Mahara F,Shiogama K, Tsutsumi Y,Takeichi T. Hemophagocytic lymphohistiocytosis in a fatal case of severe fever with thrombocytopenia syndrome. Internal Medcine. 2017;56: 1597-1602.

25.  Sato S, Shinohara S, Hayashi S, Morizumi S, Abe S, Okazaki H, Chen Y, Goto H, Aono Y, Ogawa H, Koyama K, Nishimura H, Kawano H, Toyoda Y, Uehara H, Nishioka Y. Anti-fibrotic efficacy of nintedanib in pulmonary fibrosis via the inhibition of fibrocyte activity. Respir Res 2017;18(1):172.


1. Sasaki E, Iida A, Oda S, Tsuneyama K, Fukami T, Nakajima M, Yokoi T. Pathogenic analysis of carbamazepine-induced liver injury in F344 rats focused on immune-and inflammation-related facters. Exp Toxicol Pathol. 2016 Jan;68(1):27-38.

2. Yamada A, Arakaki R, Saito M, Tsunematsu T, Kudo Y, Ishimaru N. A role of regulatory T cell in the pathogenesis of IBD. World J Gastroenterol. 2016 Feb21;22(7):2195-2205.

3. Kondo T, Tsunematsu T, Yamada A, Arakaki R, Saito M, Otsuka K, Kujiraoka S, Ushio A, Kurosawa M, Kudo Y, Ishimaru N. Acceleration of Tumor Growth due to Dysfunction in M1 Macrophages and Enhanced Angiogenesis in an Animal Model of Autoimmune Disease. Lab Invest. 2016 Jan 25.

4. Obayashi M, Yoshida M, Tsunematsu T, Ogawa I, Sasahira T, Kuniyasu H, Imoto I, Abiko Y, Xu D, Fukunaga S, Tahara H, Kudo Y, Nagao T, Takata T. MicroRNA-203 Suppresses Invasion and Epithelial-mesenchymal Transition Induction via Targeting NUAK1 and SNAI2 in Head and Neck Cancer. Oncotarget. 2016 Jan 22.

5. Saito M, Arakaki R, Yamada A, Tsunematsu T, Kudo Y, Ishimaru N. Molecular Mechanisms of Nickel Allergy. Int J Mol Sci. 2016 Feb 2;17(2).

6. Qi G, Kudo Y, Tang B, Liu T, Jin S, Liu J, Zuo X, Mi S, Shao W, Ma X, Tsunematsu T, Ishimaru N, Zeng S, Tstsuka M, Shimamoto F. PARP6 acts as a tumor suppressor via downregulating Survivin expression in colorectal cancer. Oncotarget. 2016 Feb 25.

7. Kudo Y, Tada H, Fujiwara N, Tada Y, Tsunematsu T, Miyake Y, Ishimaru N. Oral environment and cancer. Gene Environ 2016 Aug 1;38:13.

8. Tsunematsu T, Fujiwara N, Yoshida M, Takayama Y, Kujiraoka S, Qi G, Kitagawa M, Kondo T, Yamada A, Arakaki R, Miyauchi M, Ogawa I, Abiko Y, Nikawa H, Murakami S, Takata T, Ishimaru N, Kudo Y. Human odontogenic epithelial cells derived from epithelial rests of Malasses stem cell properities. Lab Invest 2016 Oct;96(10):1063-75.

9. Izawa T, Arakaki R, Mori H, Tsunematsu T, Kudo Y, Tanaka E, Ishimaru N. The nuclear receptor AhR controls bone homeostasis by regulating osteoclast differentiation via the RANK/c-FOS signaling axis. J Immunol 2016 Dec 15;197(12):4639-4650.

10. Ando T, Kudo Y, Iizuka S, Tsunematsu T, Umehara H, Shrestha M, Matsuo T, Kubo T, Shimose S, Arihiro K, Ogawa I, Ochi M, Takata T. Ameloblastin induces tumor suppressive phenotype and enhances chemosensitivity to doxorubicin via Src-Stat3 inactivation in osteosarcoma. Sci. Rep 2017 Jan 5;7:40187.

11. Qi G, Liu J, Mi S, Tsunematsu T, Jin S, Shao W, Liu T, Ishimaru N, Tang T, Kudo Y. Aurora kinase inhibitors in head and neck cancer. Curr. Top Med.Chem 2018 Jan 12.

12. Yang GX, Sun Y, Tsuneyama K, Zhang W, Leung PS, He XS, et al. Endogenous interleukin-22 protects against inflammatory bowel disease but not autoimmune cholangitis in dominant negative form of transforming growth factor beta receptor type II mice. Clin Exp Immunol. 2016;185(2):154-64.

13. Wakae H, Higashide T, Tsuneyama K, Nakamura T, Takahashi K, Sugiyama K. Immunohistochemical Characterization of the Ectopic Epithelium Devoid of Goblet Cells From a Posttraumatic Iris Cyst Causing Mucogenic Glaucoma. J Glaucoma. 2016;25(3):e291-4.

14. Takikawa A, Usui I, Fujisaka S, Ikutani M, Senda S, Hattori S, et al. Deletion of SIRT1 in myeloid cells impairs glucose metabolism with enhancing inflammatory response to adipose tissue hypoxia. Diabetology International. 2016;7(1):59-68.

15. Takahashi T, Nishida T, Baba H, Hatta H, Imura J, Sutoh M, et al. Histopathological characteristics of glutamine synthetase-positive hepatic tumor lesions in a mouse model of spontaneous metabolic syndrome (TSOD mouse). Mol Clin Oncol. 2016;5(2):267-70.

16. Takikawa A, Mahmood A, Nawaz A, Kado T, Okabe K, Yamamoto S, et al. HIF-1alpha in Myeloid Cells Promotes Adipose Tissue Remodeling Toward Insulin Resistance. Diabetes. 2016;65(12):3649-59.

17. Taira S, Yamaguchi N, Tatsuta Y, Katano H, Tsuneyama K, Kikuchi K. Liver disease risk of xenobiotics due to percutaneous absorption revealed by nano-PALDI imaging mass spectrometry. Int J Recent Sci Res 2016;7(7):12589-92.

18. Oda S, Shirai Y, Akai S, Nakajima A, Tsuneyama K, Yokoi T. Toxicological role of an acyl glucuronide metabolite in diclofenac-induced acute liver injury in mice. J Appl Toxicol. 2016.

19. Nishida T, Tsuneyama K, Fujimoto M, Nomoto K, Hayashi S, Miwa S, et al. Aberrant iron metabolism might have an impact on progression of diseases in Tsumura Suzuki obese diabetes mice, a model of spontaneous metabolic syndrome. Pathol Int. 2016;66(11):622-8.

20. Morimoto S, Ishikawa T, Hyodo K, Yamazaki T, Taira S, Tsuneyama K, et al. Preparation and characterization of newly developed matrix using functional γ‐Fe2O3 nanoparticles for mass spectrometry in small molecules. Surf Interface Anal 2016;48:1127-31.

21. Kawaguchi M, Hara N, Bilim V, Koike H, Suzuki M, Kim TS, et al. A diagnostic marker for superficial urothelial bladder carcinoma: lack of nuclear ATBF1 (ZFHX3) by immunohistochemistry suggests malignant progression. BMC Cancer. 2016;16(1):805.

22. Iwamura A, Watanabe K, Akai S, Nishinosono T, Tsuneyama K, Oda S, et al. Zomepirac Acyl Glucuronide Is Responsible for Zomepirac-Induced Acute Kidney Injury in Mice. Drug Metab Dispos. 2016;44(7):888-96.

23. Bae HR, Leung PS, Tsuneyama K, Valencia JC, Hodge DL, Kim S, et al. Chronic expression of interferon-gamma leads to murine autoimmune cholangitis with a female predominance. Hepatology. 2016;64(4):1189-201.

24. Akai S, Uematsu Y, Tsuneyama K, Oda S, Yokoi T. Kupffer cell-mediated exacerbation of methimazole-induced acute liver injury in rats. J Appl Toxicol. 2016;36(5):702-15.



Takahashi T, Baba H, Hatta H, Ogawa H, Uehara H, Nishida Y, Kataguchi I, Tsuneyama K. Oral administration of α-lipoic acid increases serum levels of ascorbic acid and tocopherol: a pilot hematologyical study. Curr Top Nutraceutical Res. 2015, in press


Nakajima T, Yagi H, Baba H, Minamisaka T, Miwa S, Hayashi S, Nishida T, Hatta H, Tsuneyama K, Imura J. Complete Resolution of Pseudomalignant Erosion in a Reflux Gastroesophageal Polyp with Proton Pump Inhibitor. Case Rep Pathol. 2015; 657059.


Tsunashima H, Tsuneyama K, Moritoki Y, Hara M, Kikuchi K. Accumulated myeloid-derived suppressor cells demonstrate distinct phenotypes and functions in two non-alcoholic steatohepatitis mouse models. Hepatobiliary Surg Nutr. 2015 Oct;4(5):313-9. 


Wakae H, Higashide T, Tsuneyama K, Nakamura T, Takahashi K, Sugiyama K. Immunohistochemical Characterization of the Ectopic Epithelium Devoid of Goblet Cells From a Posttraumatic Iris Cyst Causing Mucogenic Glaucoma. J Glaucoma. 2015 Nov 6.


Yang JB, Wang YH, Yang W, Lu FT, Ma HD, Zhao ZB, Jia YJ, Tang W, Tsuneyama K, Ridgway WM, Gershwin ME, Lian ZX. Successful treatment of murine autoimmune cholangitis by parabiosis: Implications for hematopoietic therapy. J Autoimmun. 2015 Sep 29. pii: S0896-8411(15)30041-X. 


Sasaki E, Iida A, Oda S, Tsuneyama K, Fukami T, Nakajima M, Yokoi T. Pathogenetic analyses of carbamazepine-induced liver injury in F344 rats focused on immune- and inflammation-related factors. Exp Toxicol Pathol. 2016 Jan;68(1):27-38. 


Shinoda K, Taki H, Obayashi K, Ando Y, Watanabe A, Komiya A, Fuse H, Tsuneyama K, Tobe K. Wild-type ATTR amyloidosis of the ureter in a 56-year-old woman with rheumatoid arthritis and Sjögren's syndrome. Int J Clin Exp Pathol. 2015 Jul 1;8(7):8624-7. eCollection 2015. 


Nakajima T, Sugiyama T, Baba H, Hatta H, Nishida T, Miwa S, Hayashi S, Tsuneyama K, Imura J. Bone metastasis in gastrointestinal stromal tumors preferentially occurs in patients with original tumors in sites other than the stomach. Int J Clin Exp Pathol. 2015 May 1;8(5):5955-9. eCollection 2015. 


Cui ZG, Ogawa R, Tsuneyama K, Yan G, Tao L, Shimomura A, Inadera H. Insight into the molecular mechanism of heme oxygenase-1 induction by docosahexaenoic acid in U937 cells. Chem Biol Interact. 2015 Aug 5;238:180-8.


Hayashi S, Abe Y, Tomita S, Nakanishi Y, Miwa S, Nakajima T, Nomoto K,Tsuneyama K, Fujimori T, Imura J. Primary non-gestational pure choriocarcinoma arising in the ovary: A case report and literature review. Oncol Lett. 2015 May;9(5):2109-2111.


Lam YF, Tong KK, Kwan KM, Tsuneyama K, Shu SA, Leung PSC, Chu KH. Gastrointestinal Immune Response to the Shrimp Allergen Tropomyosin: Histological and Immunological Analysis in an Animal Model of Shrimp Tropomyosin Hypersensitivity. Int Arch Allergy Immunol., 2015; 167(1):29-40.


Gao F, Yokoyama S, Fujimoto M, Tsuneyama K, Saiki I, Shimada Y, Hayakawa Y. Comparison of two Kampo medicines in a diet-induced mouse obesity model. Traditional & Kampo med. 2015, in press


Wada A, Ito A, Iitsuka H, Tsuneyama K, Miyazono T, Murakami J, Shibahara N, Sakurai H, Saiki I, Nakayama T, Yoshie O, Koizumi K, Sugiyama T. Role of chemokine CX3CL1 in progression of multiple myeloma via CX3CR1 in bone microenvironments. Oncol Rep. 2015 Jun;33(6):2935-9.


Takahashi K, Nagai N, Ogura K, Tsuneyama K, Saiki I, Irimura T, Hayakawa Y. Mammary tissue microenvironment determines T cell-dependent breast cancer-associated inflammation. Cancer Sci. 2015 Jul; 106(7):867-74.


Takai S, Oda S, Tsuneyama K, Fukami T, Nakajima M, Yokoi T. Establishment of a mouse model for amiodarone-induced liver injury and analyses of its hepatotoxic mechanism. J Appl Toxicol. 2016 jan; 36(1):35-47.


Iida A, Sasaki E, Yano A, Tsuneyama K, Fukami T, Nakajima M, Yokoi T.Carbamazepine-Induced Liver Injury Requires CYP3A-Mediated Metabolism and Glutathione Depletion in Rats. Drug Metab Dispos. 2015 Jul;43(7):958-68.


Gao F, Yokoyama S, Fujimoto M, Tsuneyama K, Saiki I, Shimada Y, Hayakawa Y. Effect of keishibukuryogan on genetic and dietary obesity models. Evid Based Complement Alternat Med. 2015;2015:801291.


Tanaka H, Yang GX, Tomiyama T, Tsuneyama K, Zhang W, Leung PS, Coppel RL, Joh T, Nadler SG, Ansari AA, Bowlus C, Gershwin ME. Immunological potential of cytotoxic T lymphocyte antigen 4 immunoglobulin in murine autoimmune cholangitis. Clin Exp Immunol. 2015 Jun;180(3):371-82.


Ichimura M, Hatanaka M, Tsuneyama K, Kato S, Omagari K. An SHR/NDmcr-cp Rat Model of Non-alcoholic steatohepatitis with advanced fibrosis induced by a High-fat, High-cholesterol Diet. J Obes Weight Loss There 2015, 5:1


Ikutani M, Tsuneyama K, Nakae S, Takatsu K. Emerging of IL-33 in inflammation and immune regulation. Inflammation and Regeneration 2015; 35(2), 69-77.


Ichimura M, Kawase M, Masuzumi M, Sakaki M, Nagata Y, Tanaka K, Suruga K, Tamaru S, Kato S, Tsuneyama K, Omagari K. High-fat and high-cholesterol diet rapidly induces non-alcoholic steatohepatitis with advanced fibrosis in Sprague-Dawley rats. Hepatol Res. 2015 Apr;45(4):458-69.


Takai S, Higuchi S, Yano A, Tsuneyama K, Fukami T, Nakajima M, Yokoi T.Involvement of immune- and inflammatory-related factors in flucloxacillin-induced liver injury in mice. J Appl Toxicol. 2015 Feb;35(2):142-51


Tezuka T, Ogawa H, Azuma M, Goto H, Uehara H, Aono Y, Hanibuchi M, Yamaguchi Y, Fujikawa T, Itai A, Nishioka Y.IMD-4690, a novel specific inhibitor for plasminogen activator inhibitor-1, reduces allergic airway remodeling in a mouse model of chronic asthma via regulating angiogenesis and remodeling-related mediators. PLoS One. 2015 Mar 18;10(3):e0121615.


Takahashi T, Uehara H, Ogawa H, Umemoto H, Bando Y, Izumi K.Inhibition of EP2/EP4 signaling abrogates IGF-1R-mediated cancer cell growth: involvement of protein kinase C-θ activation. Oncotarget. 2015 Mar 10;6(7):4829-44


Matsui T, Onouchi T, Shiogama K, Mizutani Y, Inada K, Yu F, Hayasaka D, Morita K, Ogawa H, Mahara F, Tsutsumi Y. Coated Glass Slides TACAS Are Applicable to Heat-Assisted Immunostaining and In Situ Hybridization at the Electron Microscopy Level. Acta Histochemica et Cytochemica 48(5) 2015.


Mitsuhashi A, Goto H, Saijo A, Trung VT, Aono Y, Ogino H, Kuramoto T, Tabata S, Uehara H, Izumi K, Yoshida M, Kobayashi H, Takahashi H, Gotoh M, Kakiuchi S, Hanibuchi M, Yano S, Yokomisa H, Sakiyama S, Nishioka Y. Fibrocyte-like cells mediate acquired resistance to anti-angiogenic therapy with bevacizumab. Nat Commun 6: 8792, 2015.


Takashima A, Yagi S, Yamaguchi K, Takagi E, Kanbara T, Ogawa H, Ise T, Kusunose K, Tobiume T, Yamada H, Soeki T, Wakatsuki T, Kitagawa T, Sata M, Vegetation of the Coronary Sinus that Concealed the Presence of a Coronary Arteriovenous Fistula in a Patient with Infectious Endocarditis, International Journal of Cardiology, letter to the editor2015.




守時由起、菊池健太郎、常山幸一自己免疫性胆管炎:抗ミトコンドリア抗体陰性原発性胆汁性肝硬変免疫症候群(第2版)—その他の免疫疾患を含めて– 別冊日本臨床 新領域別症候群シリーズ No. 34, 369-374. 2015

佐々塚涼弥、馬場逸人、菊池健太郎、守時由起、常山幸一原発性胆汁性肝硬変の免疫病理 肝胆膵 71(5)831−837,2015




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