2021

1: Nakamura N, Yoshida K, Tsuda R, Murata M, Yamaguchi T, Suwa K, Ichimura M, Tsuneyama K, Matsuzaki K, Nakano T, Hirohara J, Seki T, Okazaki K, Gershwin ME, Naganuma M. Phospho-Smad3 signaling is predictive biomarker for hepatocellular carcinoma risk assessment in primary biliary cholangitis patients. Front Biosci (Landmark Ed). 2021 Dec 30;26(12):1480-1492.
2: Azuma YT, Fujita T, Izawa T, Hirota K, Nishiyama K, Ikegami A, Aoyama T, Ike M, Ushikai Y, Kuwamura M, Fujii H, Tsuneyama K. IL-19 Contributes to the Development of Nonalcoholic Steatohepatitis by Altering Lipid Metabolism. Cells. 2021 Dec 13;10(12):3513.
3: Ichimura-Shimizu M, Kageyama T, Oya T, Ogawa H, Matsumoto M, Sumida S, Kakimoto T, Miyakami Y, Nagatomo R, Inoue K, Cheng C, Tsuneyama K. Verification of the Impact of Blood Glucose Level on Liver Carcinogenesis and the Efficacy of a Dietary Intervention in a Spontaneous Metabolic Syndrome Model. Int J Mol Sci. 2021 Nov 27;22(23):12844.
4: Yamazaki M, Tomii N, Tsuneyama K, Takanari H, Niwa R, Honjo H, Kodama I, Arafune T, Makita N, Sakuma I, Dobrev D, Nattel S, Tsuji Y. Rotors anchored by refractory islands drive torsades de pointes in an experimental model of electrical storm. Heart Rhythm. 2021 Oct 20:S1547-5271(21)02239-6.
5: Hatta H, Nishida T, Minamisaka T, Tsuneyama K, Imura J. Utility of Ethylene-Diamine-Tetraacetic Acid Buffer Solution With Boric Acid for Immunostaining of Specimens Stored for an Extended Period. Cureus. 2021 Aug 29;13(8):e17549.
6: Valencia JC, Erwin-Cohen RA, Clavijo PE, Allen C, Sanford ME, Day CP, Hess MM, Johnson M, Yin J, Fenimore JM, Bettencourt IA, Tsuneyama K, Romero ME, Klarmann KD, Jiang P, Bae HR, McVicar DW, Merlino G, Edmondson EF, Anandasabapathy N, Young HA. Myeloid-Derived Suppressive Cell Expansion Promotes Melanoma Growth and Autoimmunity by Inhibiting CD40/IL27 Regulation in Macrophages. Cancer Res. 2021 Dec 1;81(23):5977-5990.
7: Miyazaki K, Morine Y, Yamada S, Saito Y, Tokuda K, Okikawa S, Yamashita S, Oya T, Ikemoto T, Imura S, Hu H, Morioka H, Tsuneyama K, Shimada M. Stromal tumor-infiltrating lymphocytes level as a prognostic factor for resected intrahepatic cholangiocarcinoma and its prediction by apparent diffusion coefficient. Int J Clin Oncol. 2021 Dec;26(12):2265-2274.
8: Nishida T, Tsuneyama K, Tago Y, Nomura K, Fujimoto M, Nakajima T, Noguchi A, Minamisaka T, Hatta H, Imura J. Effect of Continuous Feeding of Ayu-Narezushi on Lipid Metabolism in a Mouse Model of Metabolic Syndrome. ScientificWorldJournal. 2021 Sep 6;2021:1583154.
9: Toki S, Yoshimaru T, Matsushita Y, Aihara H, Ono M, Tsuneyama K, Sairyo K, Katagiri T. The survival and proliferation of osteosarcoma cells are dependent on the mitochondrial BIG3-PHB2 complex formation. Cancer Sci. 2021 Oct;112(10):4208-4219.
10: Kobayashi T, Ichimura-Shimizu M, Oya T, Ogawa H, Matsumoto M, Morimoto Y, Sumida S, Kakimoto T, Yamashita M, Sutoh M, Toyohara S, Hokao R, Cheng C, Tsuneyama K. Neonatal streptozotocin treatment rapidly causes different subtype of hepatocellular carcinoma without persistent hyperglycemia in 4CS mice fed on a normal diet. Pathol Res Pract. 2021 Sep;225:153559.
11: Chen SY, Tsuneyama K, Yen MH, Lee JT, Chen JL, Huang SM. Hyperbaric oxygen suppressed tumor progression through the improvement of tumor hypoxia and induction of tumor apoptosis in A549-cell-transferred lung cancer. Sci Rep. 2021 Jun 8;11(1):12033.
12: Morimoto Y, Oya T, Ichimura-Shimizu M, Matsumoto M, Ogawa H, Kobayashi T, Sumida S, Kakimoto T, Yamashita M, Cheng C, Tsuneyama K. Applying Probe Electrospray Ionization Mass Spectrometry to Cytological Diagnosis: A Preliminary Study by Using Cultured Lung Cancer Cells. Acta Cytol. 2021;65(5):430-439.
13: Miyazaki K, Morine Y, Imura S, Ikemoto T, Saito Y, Yamada S, Tokuda K, Okikawa S, Yamashita S, Oya T, Tsuneyama K, Shimada M. Preoperative lymphocyte/C-reactive protein ratio and its correlation with CD8+ tumor-infiltrating lymphocytes as a predictor of prognosis after resection of intrahepatic cholangiocarcinoma. Surg Today. 2021 Dec;51(12):1985-1995.
14: Yamashita S, Morine Y, Imura S, Ikemoto T, Saito Y, Takasu C, Yamada S, Tokuda K, Okikawa S, Miyazaki K, Oya T, Tsuneyama K, Shimada M. A new pathological classification of intrahepatic cholangiocarcinoma according to protein expression of SSTR2 and Bcl2. World J Surg Oncol. 2021 May 7;19(1):142.
15: Shimoyama S, Kawata K, Ohta K, Chida T, Suzuki T, Tsuneyama K, Shimoda S, Kurono N, Leung PSC, Gershwin ME, Suda T, Kobayashi Y. Ursodeoxycholic acid impairs liver-infiltrating T-cell chemotaxis through IFN-γ and CX3CL1 production in primary biliary cholangitis. Eur J Immunol. 2021 Jun;51(6):1519-1530.
16: Ichimura-Shimizu M, Omagari K, Yamashita M, Tsuneyama K. Development of a novel mouse model of diet-induced nonalcoholic steatohepatitis-related progressive bridging fibrosis. Biosci Biotechnol Biochem. 2021 Mar 24;85(4):941-947.
17: Matsumoto K, Kikuchi K, Hara A, Tsunashima H, Tsuneyama K, Doi S. Immunohistochemical detection of procalcitonin in fibrolamellar hepatocellular carcinoma. Clin J Gastroenterol. 2021 Jun;14(3):827-830.
18: Tanaka H, Saijo Y, Tomonari T, Tanaka T, Taniguchi T, Yagi S, Okamoto K, Miyamoto H, Sogabe M, Sato Y, Muguruma N, Tsuneyama K, Sata M, Takayama T. An Adult Case of Congenital Extrahepatic Portosystemic Shunt Successfully Treated with Balloon-occluded Retrograde Transvenous Obliteration. Intern Med. 2021 Jun 15;60(12):1839-1845.
 19:Influence of age in weeks on the development and progression of nonalcoholic steatohepatitis in a diet-induced Sprague-Dawley rat model. Omagari K, Yamasaki M, Ngo LCT, Koba C, Nagata A, Fukuda A, Suruga K, Ichimurs-Shimizu M, Tsuneyama K Acta Medica Nagasakiensia 2021 65(1): 7-15.
 20:Olive leaf powder prevents nonalcoholic steatohepatitis in Sprague–Dawley rats fed a high-fat and high-cholesterol diet. Omagari K, Koba C, Nagaa A, Ngo LCT, Yamasaki M, Fukuda A, Yuasa M, Suruga K, Inada N, Ichimura-Shimizu M, Tsuneyama K.  Clinical Nutrition Open Science. 2021 37: 47-59.
21: Tezuka T, Azuma M, Ogawa H, Kondo M, Uehara H, Aono Y, Hanibuchi M, Nishioka Y. A RAS inhibitor reduces allergic airway remodeling via regulating IL-33-derived type 2 innate lymphoid cells. Exp Lung Res 47(9):451-463, 2021
22: Takasu C, Miyazaki K, Yoshikawa K, Nishi M, Tokunaga T, Kashihara H, Yoshimoto T, Ogawa H, Morine Y, Shimada M. Effect of TU-100 on Peyer's patches in a bacterial translocation rat model. Ann Gastroenterol Surg. 2021 Apr 5;5(5):683-691.
23: Yoshida M, Yuasa M, Ogawa H, Miyamoto N, Kawakami Y, Kondo K, Tangoku A. Can computed tomography differentiate adenocarcinoma in situ from minimally invasive adenocarcinoma? Thorac Cancer. 2021 Apr;12(7):1023-1032.
24: Kondo M, Tezuka T, Ogawa H, Koyama K, Bando H, Azuma M, Nishioka Y. Lysophosphatidic Acid Regulates the Differentiation of Th2 Cells and Its Antagonist Suppresses Allergic Airway Inflammation. Int Arch Allergy Immunol. 2021;182(1):1-13.
25: Ichimura-Shimizu M, Tsuchiyama Y, Morimoto Y, Matsumoto M, Kobayashi T, Sumida S, Kakimoto T, Oya T, Ogawa H, Yamashita M, Matsuda S,  Omagari K, Taira S, Tsuneyama K. A novel mouse model of non-alcoholic steatohepatitis suggests that liver fibrosis initiates around lipid-laden macrophages. American Journal of Pathology, Vol. 192 (1), pp.31-42, 2021
26. 清水真祐子.非アルコール性脂肪肝炎および脳機能障害における脂質の挙動. アグリバイオ, Vol.5, No.6, 521-525, 2021.

2020

1: Umezu T, Tsuneyama K, Kanekura K, Hayakawa M, Tanahashi T, Kawano M, Taguchi YH, Toyoda H, Tamori A, Kuroda M, Murakami Y. Comprehensive analysis of liver and blood miRNA in precancerous conditions. Sci Rep. 2020 Dec 10;10(1):21766.
2: Minamikawa T, Ichimura-Shimizu M, Takanari H, Morimoto Y, Shiomi R, Tanioka H, Hase E, Yasui T, Tsuneyama K. Molecular imaging analysis of microvesicular and macrovesicular lipid droplets in non-alcoholic fatty liver disease by Raman microscopy. Sci Rep. 2020 Oct 29;10(1):18548.
3: Kondo M, Izawa-Ishizawa Y, Goda M, Hosooka M, Kagimoto Y, Saito N, Matsuoka R, Zamami Y, Chuma M, Yagi K, Takechi K, Tsuneyama K, Ishizawa K. Preventive Effects of Quercetin against the Onset of Atherosclerosis-Related Acute Aortic Syndromes in Mice. Int J Mol Sci. 2020 Sep 30;21(19):7226.
4: Tsunematsu T, Arakaki R, Kawai H, Ruppert J, Tsuneyama K, Ishimaru N, Earnshaw WC, Pagano M, Kudo Y. APC/C Cdh1 is required for the termination of chromosomal passenger complex activity upon mitotic exit. J Cell Sci. 2020 Sep 15;133(18):jcs251314.
5: Kurano M, Tsukamoto K, Hara M, Tsuneyama K, Nishikawa T, Ikeda H, Yatomi Y. Modulation of sphingosine 1-phosphate by hepatobiliary cholesterol handling. FASEB J. 2020 Nov;34(11):14655-14670.
6: Li M, Wu C, Muhammad JS, Yan D, Tsuneyama K, Hatta H, Cui ZG, Inadera H. Melatonin sensitises shikonin-induced cancer cell death mediated by oxidative stress via inhibition of the SIRT3/SOD2-AKT pathway. Redox Biol. 2020 Sep;36:101632.
7: Akatsu H, Manabe T, Kawade Y, Tanaka H, Kanematsu T, Arakawa K, Masaki Y, Hishida C, Kanesaka T, Ogawa N, Hashizume Y, Tsuneyama K, Ohara H, Maruyama M, Yamamoto T. Iron deposition in autopsied liver specimens from older patients receiving intravenous iron infusion. PLoS One. 2020 Aug 4;15(8):e0237104.
8: Oda S, Miyazaki N, Tsuneyama K, Yokoi T. Exacerbation of gefitinib-induced liver injury by glutathione reduction in mice. J Toxicol Sci. 2020;45(8):493-502.
 9: Andoh T, Suzuki K, Konno M, Tsuneyama K, Kuraishi Y. Pharmacological Characterization of a Novel Mouse Model of Cholestatic Pruritus. Biol Pharm Bull. 2020;43(7):1111-1117.
 10: Tsutsui A, Harada K, Tsuneyama K, Nguyen Canh H, Ando M, Nakamura S, Mizobuchi K, Baba N, Senoh T, Nagano T, Shibata H, Aoki T, Takaguchi K. Histopathological analysis of autoimmune hepatitis with "acute" presentation: Differentiation from drug-induced liver injury. Hepatol Res. 2020 Sep;50(9):1047-1061.
 11: Imanishi M, Yamakawa Y, Fukushima K, Ikuto R, Maegawa A, Izawa-Ishizawa Y, Horinouchi Y, Kondo M, Kishuku M, Goda M, Zamami Y, Takechi K, Chuma M, Ikeda Y, Tsuchiya K, Fujino H, Tsuneyama K, Ishizawa K. Fibroblast-specific ERK5 deficiency changes tumor vasculature and exacerbates tumor progression in a mouse model. Naunyn Schmiedebergs Arch Pharmacol. 2020 Jul;393(7):1239-1250.
 12: Takai A, Kikuchi K, Ichimura M, Tsuneyama K, Moritoki Y, Matsumoto K, Tsunashima H, Onda T, Kuniyoshi N, Nariyama T, Ohyatsu S, Kubota J, Nagumo K, Sato S, Hara M, Miyakawa H. Fructo-oligosaccharides ameliorate steatohepatitis, visceral adiposity, and associated chronic inflammation via increased production of short-chain fatty acids in a mouse model of non-alcoholic steatohepatitis. BMC Gastroenterol. 2020 Feb 27;20(1):46.
 13: Suwa K, Yamaguchi T, Yoshida K, Murata M, Ichimura M, Tsuneyama K, Seki T, Okazaki K. Smad Phospho-Isoforms for Hepatocellular Carcinoma Risk Assessment in Patients with Nonalcoholic Steatohepatitis. Cancers (Basel). 2020 Jan 24;12(2):286.
 14: Omagari K, Suzuta M, Taniguchi A, Kumamoto R, Koyama Y, Fukuda A, Suruga K, Ichimura-Shimizu M, Tsuneyama K. A non-obese, diet-induced animal model of nonalcoholic steatohepatitis in Wistar/ST rats compared to Sprague-Dawley rats Clinical Nutrition Experimental 2020; 30: 1-14
15: Otsuka K, Mitsuhashi A, Goto H, Hanibuchi M, Koyama K, Ogawa H, Ogino H, Saijo A, Kozai H, Yoneda H, Tobiume M, Kishuku M, Ishizawa K, Nishioka Y. Anti- PD-1 antibody combined with chemotherapy suppresses the growth of mesothelioma by reducing myeloid-derived suppressor cells. Lung Cancer. 2020 Aug;146:86-96.
 16: Morizumi S, Sato S, Koyama K, Okazaki H, Chen Y, Goto H, Kagawa K, Ogawa H, Nishimura H, Kawano H, Toyoda Y, Uehara H, Nishioka Y. Blockade of Pan- Fibroblast Growth Factor Receptors Mediates Bidirectional Effects in Lung Fibrosis. Am J Respir Cell Mol Biol. 2020 Sep;63(3):317-326.

2019

1. Iida A, Kuranuki A, Yamamoto R, Uchida M, Ohta M, Ichimura M, Tsuneyama K, Masaki T, Seike M, Nakamura T. Analysis of amino acid profiles of blood over time and biomarkers associated with non-alcoholic steatohepatitis in STAM mice. Experimental Animals, 2019: 68, No.4, 417-428.
2. Fukuda A, Sasao M, Asakawa E, Narita S, Hisano M, Suruga K, Ichimura M, Tsuneyama K, Tanaka K, Omagari K. Dietary fat, cholesterol, and cholic acid affect the histopathologic severity of nonalcoholic steatohepatitis in Sprague-Dawley rats. Pathology, Research and Practice 215(11): 152599, 2019.
3. Omagari K, Asakawa E, Sasao M, Narita S, Hisano M, Fukuda A, Suruga K, Ichimura M, Tsuneyama K. Age-related alterations of nonalcoholic steatohepatitis in Sprague-Dawley rats fed a high-fat and high-cholesterol diet. Journal of Nutritional Science and Vitaminology, 65, (4): 349-356, 2019.
4. Kageyama C, Igawa T, Gion Y, Iwaki N, Tabata T, Tanaka T, Kondo E, Sakai H, Tsuneyama K, Nomoto K, Noguchi H, Yoshino T, Yokota K, Sato Y. Hepatic Campylobacter jejuni infection in patients with Castleman-Kojima disease (idiopathic multicentric Castleman disease with thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly (TAFRO) syndrome). Pathology International, Vol.69, No.10, 572-579, 2019.
5. Terziroli BBP, Mieli-Vergani G, Vergani D, Vierling MJ, Adams D, Alpini G, Banales MJ, Beuers U, Björnsson E, Bowlus C, Carbone M, Chazouillères O, Dalekos G, Gottardi De A, Harada K, Hirschfield G, Invernizzi P, Jones D, Krawitt E, Lanzavecchia A, Lian ZX, Ma X, Manns M, Mavilio D, Quigley ME, Sallusto F, Shimoda S, Strazzabosco M, Swain M, Tanaka A, Trauner M, Tsuneyama K, Zigmond E, Gershwin  EM. The challenges of primary biliary cholangitis: What is new and what needs to be done.Journal of Autoimmunity, Vol.105, 2019.
6. Jia R, Oda S,  Tsuneyama K, Urano Y,  Yokoi T. Establishment of a mouse model of troglitazone-induced liver injury and analysis of its hepatotoxic mechanism. Journal of Applied Toxicology : JAT, 2019.
7. Yang F, Takeuchi T, Tsuneyama K, Yokoi T, Oda S. Experimental Evidence of Liver Injury by BSEP-Inhibiting Drugs With a Bile Salt Supplementation in Rats. Toxicological Sciences, Vol.170, No.1, 95-108, 2019.
8. Takahashi T, Ichikawa H, Morimoto Y, Tsuneyama K, Hijikata T. Inhibition of EP2/EP4 prostanoid receptor-mediated signaling suppresses IGF-1-induced proliferation of pancreatic cancer BxPC-3 cells via upregulating γ-glutamyl cyclotransferase expression.,Biochemical and Biophysical Research Communications, Vol.516, No.2, 388-396, 2019.
9. Takikawa A, Usui I, Fujisaka S, Tsuneyama K, Okabe K, Nakagawa T, Nawaz A, Kado T, Jojima T, Aso Y, Hayakawa Y, Yagi K, Tobe K. Macrophage-specific hypoxia-inducible factor-1α deletion suppresses the development of liver tumors in high-fat diet-fed obese and diabetic mice. Journal of Diabetes Investigation, Vol.10, No.6, 1411-1418, 2019.
10. Kurano M, Tsuneyama K, Morimoto Y, Nishikawa M, Yutaka Yatomi. Apolipoprotein M suppresses the phenotypes of IgA nephropathy in hyper-IgA mice.The FASEB journal, Vol.33, No.4, 5181-5195, 2019.
11. Izawa-Ishizawa Y, Imanishi M, Zamami Y, Hiroki T, Tomoko N, Morishita M, Tsuneyama K, Horinouchi Y, Kihira Y, Takechi K, Ikeda Y, Tsuchiya K,  Yoshizumi M, Tamaki T, Ishizawa K. Development of a novel aortic dissection mouse model and evaluation of drug efficacy using in-vivo assays and database analyses. Journal of Hypertension, Vol.37, No.1, 73-83, 2019.
12. Okazaki H, Satou S, Koyama K, Morizumi S, Abe S, Azuma M, Chen Y, Goto H,  Aono H, Ogawa H, Kagawa K, Nishimura H, Kawano H, Toyoda Y, Uehara H, Kouji H, Nishioka Y. The novel inhibitor PRI-724 for Wnt/β-catenin/CBP signaling ameliorates bleomycin-induced pulmonary fibrosis in mice. Experimental Lung Research, Vol.45, No.7, 188-199, 2019.
13. Koyama K, Goto H, Morizumi S, Kagawa K, Nishimura H, Satou S, Kawano H, Toyoda Y, Ogawa H, Homma S, Nishioka Y. The Tyrosine Kinase Inhibitor TAS-115 Attenuates Bleomycin-induced Lung Fibrosis in Mice. American Journal of Respiratory Cell and Molecular Biology, Vol.60, No.4, 478-487, 2019.

2018

1. Matsubara A, Oda S, Akai S, Tsuneyama K, Yokoi T. Establishment of a drug-induced rhabdomyolysis mouse model by co-administration of ciprofloxacin and atorvastatin. Toxicol Lett. 2018 Apr 18;291:184-193. 
2. Kurano M, Tsuneyama K, Morimoto Y, Shimizu T, Jona M, Kassai H, Nakao K, Aiba A, Yatomi Y. Apolipoprotein M protects lipopolysaccharide-treated mice from death and organ injury. Thromb Haemost. 2018 in press 
3. Takahashi T, Deuschle U, Taira S, Nishida T, Fujimoto M, Hijikata T, Tsuneyama K. Tsumura-Suzuki obese diabetic mice-derived hepatic tumors closely resemble human hepatocellular carcinomas in metabolism-related genes expression and bile acid accumulation. Hepatol Int. 2018 in press 
4. Akashi M, Tajiri K, Wada A, Tsuneyama K, Kawai K, Yasumura S, Minemura M, Takahara T, Sugiyama T. A patient with non-alcoholic steatohepatitis complicated by multiple myeloma. Intern Med. 2018 in press
5. Joshita S, Yoshizawa K, Umemura T, Ohira H, Takahashi A, Harada K, Hiep NC,Tsuneyama K, Kage M, Nakano M, Kang JH, Koike K, Zeniya M, Yasunaka T, Takaki A, Torimura T, Abe M, Yokosuka O, Tanaka A, Takikawa H; Japan Autoimmune Hepatitis Study Group (JAIHSG). Clinical features of autoimmune hepatitis with acute presentation: a Japanese nationwide survey. J Gastroenterol. 2018 in press
6: Oda S, Takeuchi M, Akai S, Shirai Y, Tsuneyama K, Yokoi T. miRNA in rat liver sinusoidal endothelial cells and hepatocytes and application to circulating
biomarkers that discern pathogenesis of liver injuries. Am J Pathol. 2018 Apr;188(4):916-928. 
7: Yamashita S, Oda S, Endo H, Tsuneyama K, Yokoi T. Neutrophil depletion protects against zomepirac-induced acute kidney injury in mice. Chem Biol Interact. 2018 Jan 5;279:102-110. 
8. 常山幸一. 少ない介入で作製するメタボリックシンドローム関連疾患モデル動物のヒト病態解析への有用性. 肝臓, 2018 59(2):92-101
9.Ogawa H, Azuma M, Tsunematu T, Morimoto Y, Kondo M, Tezuka T, Nishioka Y, Tsuneyama K. Neutrophils induce smooth muscle hyperplasia via neutrophil elastase-induced FGF-2 in a mouse model of asthma with mixed inflammation.Clin Exp Allergy. 2018
10. Saijo A,  Goto H, Nakano M, Mitsuhashi A, Aono Y, Hanibuchi M, Ogawa HUehara H, Kondo K, Nishioka Y. Bone marrow-derived fibrocytes promote stem cell-like properties of lung cancer cells. Cancer Letters 2018
11. Omagari K, Fukuda A, Suga M, Ogata A, Nishioka S, Suruga K, Ichimura M, Tsuneyama K. Peptides Obtained by Enzymatic Decomposition of Mackerel Prevent Nonalcoholic Steatohepatitis in Sprague-Dawley Rats fed a High-fat and High-cholesterol Diet. OBM Hepatology and Gastroenterology 2(3), 2018.
12. Nagatomo R, Okada Y, Ichimura MTsuneyama K, Inoue K. Application of 2-Picolylamine Derivatized Ultra-high Performance Liquid Chromatography Tandem Mass Spectrometry for Determination of Short-chain Fatty Acids in Feces Samples. Analytical Sciences, 2018 34 (9)
13. Fujimoto S, Muguruma N, Okamoto K, Kurihara T, Sato Y, Miyamoto Y, Kitamura S, Miyamoto H, Taguchi T, Tsuneyama K, Takayama T. A novel theranostic combination of near-infrared fluorescence imaging and laser irradiation targeting c-KIT for gastrointestinal stromal tumors. Theranostics 2018 Mar 21;8(9):2313-2328. DOI:10.7150/thno.22027
14. Takeuchi M, Oda S, Tsuneyama K, Yokoi T. Comprehensive analysis of serum microRNAs in hepatic sinusoidal obstruction syndrome (SOS) in rats: implication as early phase biomarkers for SOS. Arch Toxicol 2018 Sep;92(9):2947-2962.DOI:10.1007/s00204-018-2269-x
15. Gao CY, Yao Y, Li L, Yang SH, Chu H, Tsuneyama K, Li XM, Gershwin ME, Lian ZX. Tissue-Resident Memory CD8+ T Cells Acting as Mediators of Salivary Gland Damage in a Murine Model of Sjögren's Syndrome. Arthritis Rheumatol. 2018 Jul 23. in press DOI:10.1002/art.40676
16. Kondo M, Ogino H, Ogawa H, Afroj T, Toyoda Y, Sakaguchi S, Tsuboi M, Bando Y, Goto H, Tsuneyama K, Nishioka Y. A case of pulmonary pleomorphic carcinoma with malignant phenotypes induced by ZEB1-associated epithelial-mesenchymal transition. Respir Med Case Rep. 2018 Aug 3;25:119-121. DOI:10.1016/j.rmcr.2018.07.008
17. Kagemoto K, Okamoto K, Takaoka T, Sato Y, Kitamura S, Kimura T, Sogabe M, Miyamoto H, Muguruma N, Tsuneyama K, Takayama T. Detection of aberrant crypt foci with image-enhanced endoscopy. Endosc Int Open 2018 Aug;6(8):E924-E933.DOI:10.1055/a-0621-8794
18. Urano Y, Oda S, Tsuneyama K, Yokoi T. Comparative hepatic transcriptome analyses revealed possible pathogenic mechanisms of fasiglifam (TAK-875)-induced acute liver injury in mice. Chem Biol Interact 2018 Dec 25;296:185-197. DOI:10.1016/j.cbi.2018.09.011 
19. Izawa-Ishizawa Y, Imanishi M, Zamami Y, Toya H, Nagao T, Morishita M,Tsuneyama K, Horinouchi Y, Kihara Y, Takechi K, Ikeda Y, Tsuchiya K, Yoshizumi M, Tamaki T, Ishizawa K. Development of a novel aortic dissection mouse model and evaluation of drug efficacy using in-vivo assays and database analyses. J Hypertens 2019 Jan; 37(1):73-83.
20. Ma HD, Zhao ZB, Ma WT, Liu QZ, Gao CY, Li L, Wang J, Tsuneyama K, Liu B, Zhang W, Zhou Y, Gershwin ME, Lian ZX. Gut microbiota translocation promotes autoimmune cholangitis. J Autoimmun 2018 Dec;95:47-57.
21. Nishitsuji K, Watanabe S, Xiao J, Nagatomo R, Ogawa H, Tsunematsu T, Umemoto H, Morimoto Y, Akatsu H, Inoue K, Tsuneyama K. Effect of coffee or coffee components on gut microbiome and short-chain fatty acids in a mouse model of metabolic syndrome. Sci Rep 2018 Nov 1;8(1):16173.
22. Morimoto J, Nishikawa Y, Kakimoto T, Furutani K, Kihara N, Matsumoto M, Tsuneyama K, Kozono Y, Kozono H, Hozumi K, Hosomichi K, Nishijima H, Matsumoto M. Aire Controls in Trans the Production of Medullary Thymic Epithelial Cells Expressing Ly-6C/Ly-6G. J Immunol 2018 Dec 1;201(11):3244-3257.
23. Moritoki Y, Tsuneyama K, Nakamura Y, Kikuchi K, Shiota A, Ohsugi Y, Lian ZX, Zhang W, Yang GX, Ueki S, Takeda M, Omokawa A, Saga T, Saga A, Watanabe D, Miura M, Ueno Y, Leung PSC, Tanaka A, Gershwin ME, Hirokawa M. Anti-drug Antibodies Against a Novel Humanized Anti-CD20 Antibody
Impair Its Therapeutic Effect on Primary Biliary Cholangitis in Human CD20- and FcγR-Expressing Mice. Front Immunol 2018 Nov 2;9:2534.
24. Omagari K, Suruga K, Kyogoku A, Nakamura S, Nakamoto A, Nishioka S, Ichimura M, Miyata Y, Tajima K, Tsuneyama K, Tanaka K. A fermented mixed tea made with camellia (Camellia japonica) and third-crop green tea leaves prevents nonalcoholic steatohepatitis in Sprague-Dawley rats fed a high-fat and high-cholesterol diet. Hepatobiliary Surg Nutr 2018 Jun; 7(3):175-184.
25. Kurano M, Tsuneyama K, Morimoto Y, Nishikawa M, Yatomi Y. Apolipoprotein M Suppresses the Phenotypes of IgA Nephropathy in Hyper-IgA mice. FASEB J, in press
26. Kishi M, Aono Y, Sato S, Koyama K, Azuma M, Abe S, Kawano H, Kishi J, Toyoda Y, Okazaki H, Ogawa H, Uehara H, Nishioka Y. Blockade of platelet-derived growth factor receptor-β, not receptor-α ameliorates bleomycin-induced pulmonary fibrosis in mice. PLOS ONE, in press.
27. Koyama K, Goto H, Morizumi S, Kagawa K, Nishimura H, Sato S, Kawano H, Toyoda Y, Ogawa H, Homma S, Nishioka Y. Novel multiple tyrosine kinase inhibitor TAS-115 attenuates bleomycin-induced lung fibrosis in mice. Am J Respir Cell Mol Biol, in press.
28. Izumi Y, Ogawa H, Uehara H, Murayama S, Sata M, Kaji R, Distinct Incidence of Takotsubo Syndrome between Amyotrophic Lateral Sclerosis and Synucleinopathies: A Cohort Study. Frontiers in Neurology in press
 

2017

1. Mouri Y, Ueda Y, Yamano T, Matsumoto M, Tsuneyama K, Kinashi T, Matsumoto M.Mode of tolerance induction and requirement for aire are governed by the cell types that express self-antigen and those that present antigen. J Immunol. 2017 Dec 15;199(12):3959-3971.

2. Tsuneyama K, Nishitsuji K, Matsumoto M, Kobayashi T, Morimoto Y, Tsunematsu T, Ogawa H. Animal models for analyzing metabolic syndrome-associated liver diseases. Pathol Int. 2017 Nov;67(11):539-546.

3. Nishitsuji K, Xiao J, Nagatomo R, Umemoto H, Morimoto Y, Akatsu H, Inoue K, Tsuneyama K. Analysis of the gut microbiome and plasma short-chain fatty acid profiles in a spontaneous mouse model of metabolic syndrome. Sci Rep. 2017 Nov 20;7(1):15876.

4. Tsutsui A, Harada K, Tsuneyama K, Senoh T, Nagano T, Takaguchi K, Ando M, Nakamura S, Mizobuchi K, Kudo M. Clinicopathological study of autoimmune hepatitis cases that were difficult to differentiate from drug-induced liver injury. Dig Dis. 2017 Oct ;35(6):506-514.

5. Fujimoto Y, Tsuneyama K, Kuramoto N, Hayashi S, Yoshida N, Morioka A, Teramoto M, Nakajima H, Takeuchi T, Azuma YT. Exacerbated experimental pancreatitis in interleukin-19 knockout mice. Glob Drugs Therap. 2017 in press.

6. Tsuneyama K, Baba H, Matsumoto M, Kobayashi T, Morimoto Y, Tsunematsu T, Ogawa H. Effectiveness of new animal models for the analysis of metabolic syndrome-associated liver diseases. Patrol Int. 2017 in press

7. Nishijima H, Kajimoto T, Matsuoka Y, Mouri Y, Morimoto J, Matsumoto M, Kawano H, Nishioka Y, Uehara H, Izumi K, Tsuneyama K, Okazaki IM, Okazaki T, Hosomichi K, Shiraki A, Shibutani M, Mitsumori K, Matsumoto M. Paradoxical development of polymyositis-like autoimmunity through augmented expression of autoimmune regulator (AIRE). J Autoimmun. 2017 in press

8. Bae HR, Hodge DL, Yang GX, Leung PSC, Chodisetti SB, Valencia JC, Sanford M, Fenimore JM, Rahman ZSM, Tsuneyama K, Norman GL, Gershwin ME, Young HA. The interplay of type I and type II interferons in murine autoimmune cholangitis as a basis for sex-biased autoimmunity. Hepatology. 2017 in press

9. Baba H, Kurano M, Nishida T, Hatta H, Hokao R, Tsuneyama K. Facilitatory effect of insulin treatment on hepatocellular carcinoma development in diabetes.  BMC Res Notes. 2017 Sep 13;10(1):478.

10. Nawaz A, Aminuddin A, Kado T, Takikawa A, Yamamoto S, Tsuneyama K, Igarashi Y, Ikutani M, Nishida Y, Nagai Y, Takatsu K, Imura J, Sasahara M, Okazaki Y, Ueki K, Okamura T, Tokuyama K, Ando A, Matsumoto M, Mori H, Nakagawa T, Kobayashi N, Saeki K, Usui I, Fujisaka S, Tobe K. CD206(+) M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors. Nat Commun. 2017 Aug 18;8(1):286.

11. Matsumoto K, Ichimura M, Tsuneyama K, Moritoki Y, Tsunashima H, Omagari K, Hara M, Yasuda I, Miyakawa H, Kikuchi K. Fructo-oligosaccharides and intestinal barrier function in a methionine-choline-deficient mouse model of nonalcoholic steatohepatitis. PLoS One. 2017 Jun 20;12(6):e0175406.

12. Takeuchi M, Matsuzaki K, Tsuneyama K, Nishimura M, Takiguchi E, Harada M. Ovarian Large Cell Neuroendocrine Carcinoma Associated with Serous Carcinoma: Correlation of Pathology with MR Imaging. Magn Reson Med Sci. 2017 Oct 10;16 (4):273-274.

13. Shimada S, Tajiri K, Baba H, Minemura M, Tsuneyama K, Nakano M, Sugiyama T. Peritumoral Hyperplasia in Hepatic Sclerosed Hemangioma. ACG Case Rep J. 2017 Apr 26;4:e61.

14. Nguyen Canh H, Harada K, Ouchi H, Sato Y, Tsuneyama K, Kage M, Nakano M, Yoshizawa K, Takahashi A, Abe M, Kang JH, Koike K, Inui A, Fujisawa T, Takaki A, Arinaga-Hino T, Torimura T, Suzuki Y, Fujiwara K, Zeniya M, Ohira H, Tanaka A, Takikawa H; Intractable Liver and Biliary Diseases Study Group of Japan. Acute presentation of autoimmune hepatitis: a multicentre study with detailed histological evaluation in a large cohort of patients. J Clin Pathol. 2017 Nov;70(11):961-969.

15. Ikutani M, Tsuneyama K, Kawaguchi M, Fukuoka J, Kudo F, Nakae S, Arita M, Nagai Y, Takaki S, Takatsu K. Prolonged activation of IL-5-producing ILC2 causes  pulmonary arterial hypertrophy. JCI Insight. 2017 Apr 6;2(7):e90721.

16. Tsuneyama K, Baba H, Morimoto Y, Tsunematsu T, Ogawa H. Primary Biliary Cholangitis: Its Pathological Characteristics and Immunopathological Mechanisms.  J Med Invest. 2017;64(1.2):7-13.

17. Watanabe S, Takahashi T, Ogawa H, Uehara H, Tsunematsu T, Baba H, Morimoto Y, Tsuneyama K. Daily Coffee Intake Inhibits Pancreatic Beta Cell Damage and Nonalcoholic Steatohepatitis in a Mouse Model of Spontaneous Metabolic Syndrome,  Tsumura-Suzuki Obese Diabetic Mice. Metab Syndr Relat Disord. 2017 May;15(4):170-177.

18. Chang C, Lleo A, Kananurak A, Grizzi F, Tsuneyama K, Invernizzi P, Bevins CL, Bowlus CL. Human β-Defensin 2 in Primary Sclerosing Cholangitis. Clin Transl Gastroenterol. 2017 Mar 16;8(3):e80.

19. Shirai Y, Oda S, Makino S, Tsuneyama K, Yokoi T. Establishment of a mouse model of enalapril-induced liver injury and investigation of the pathogenesis. Lab Invest. 2017 Jul;97(7):833-842.

20. Ma HD, Ma WT, Liu QZ, Zhao ZB, Liu MZ, Tsuneyama K, Gao JM, Ridgway WM, Ansari AA, Gershwin ME, Fei YY, Lian ZX. Chemokine receptor CXCR3 deficiency exacerbates murine autoimmune cholangitis by promoting pathogenic CD8(+) T cell activation. J Autoimmun. 2017 Mar;78:19-28.

21. Ichimura M, Masuzumi M, Kawase M, Sakaki M, Tamaru S, Nagata Y, Tanaka K, Suruga K, Tsuneyama K, Matsuda S, Omagari K. A diet-induced Sprague-Dawley rat model of nonalcoholic steatohepatitis-related cirrhosis. J Nutr Biochem. 2017 Feb;40:62-69.

22. Oda S, Shirai Y, Akai S, Nakajima A, Tsuneyama K, Yokoi T. Toxicological role of an acyl glucuronide metabolite in diclofenac-induced acute liver injuly in mice. J Appl Toxicol. 2017 may;37(5):545-553.

23.  Kawashita Y, Morine Y, Ikemoto T, Saito Y, Iwahashi S, Yamada S, Higashijima J, Imura S, Ogawa H, Yagi T, Shimada M. Loss of Fbxw7 expression is a predictor of recurrence in colorectal liver metastasis. J Hepatobilliary Pancreat Sci. 2017 Aug;24:576-583.

24. Nakano AOgawa H, Nakanishi Y, Fujita H, Mahara F,Shiogama K, Tsutsumi Y,Takeichi T. Hemophagocytic lymphohistiocytosis in a fatal case of severe fever with thrombocytopenia syndrome. Internal Medcine. 2017;56: 1597-1602.

25.  Sato S, Shinohara S, Hayashi S, Morizumi S, Abe S, Okazaki H, Chen Y, Goto H, Aono Y, Ogawa H, Koyama K, Nishimura H, Kawano H, Toyoda Y, Uehara H, Nishioka Y. Anti-fibrotic efficacy of nintedanib in pulmonary fibrosis via the inhibition of fibrocyte activity. Respir Res 2017;18(1):172.

その他の記事...

  1. 2016

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  3. 2014

  4. 2013