研究業績 2019年

  • Toyoda Y, Takada T, Yamanashi Y, Suzuki H. Pathophysiological importance of bile cholesterol reabsorption: hepatic NPC1L1-exacerbated steatosis and decreasing VLDL-TG secretion in mice fed a high-fat diet. Lipids Health Dis. 2019 18:234. [open access]
  • Toyoda Y, Pavelcová K, Klein M, Suzuki H, Takada T, Stiburkova B. Familial early-onset hyperuricemia and gout associated with a newly identified dysfunctional variant in urate transporter ABCG2. Arthritis Res Ther. 2019 21(1):219. [open access]
  • Manabe Y, Ichihara M, Fukuda K, Tomonaga N, Li ZS, Yamanashi Y, Suzuki H, Takada T, Matsuo M, Sugawara T. Niemann-Pick C1-like 1 Promotes Intestinal Absorption of Siphonaxanthin. Lipids 2019 54(11-12):707-714. [abstract]
  • Kawamura Y, Nakaoka H, Nakayama A, Okada Y, Yamamoto K, Higashino T, Sakiyama M, Shimizu T, Ooyama H, Ooyama K, Nagase M, Hidaka Y, Shirahama Y, Hosomichi K, Nishida Y, Shimoshikiryo I, Hishida A, Katsuura-Kamano S, Shimizu S, Kawaguchi M, Uemura H, Ibusuki R, Hara M, Naito M, Takao M, Nakajima M, Iwasawa S, Nakashima H, Ohnaka K, Nakamura T, Stiburkova B, Merriman TR, Nakatochi M, Ichihara S, Yokota M, Takada T, Saitoh T, Kamatani Y, Takahashi A, Arisawa K, Takezaki T, Tanaka K, Wakai K, Kubo M, Hosoya T, Ichida K, Inoue I, Shinomiya N, Matsuo H. Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout. Ann Rheum Dis. 2019 78(10):1430-1437. [abstract]
  • Yamamoto H, Yamanashi Y, Takada T, Mu S, Tanaka Y, Komine T, Suzuki H. Hepatic expression of Niemann-Pick C1-Like 1, a cholesterol re-absorber from bile, exacerbates western diet-induced atherosclerosis in LDL receptor mutant mice. Mol Pharmacol. 2019 96(1):47-55. [abstract]
  • Toyoda Y, Mančíková A, Krylov V, Morimoto K, Pavelcová K, Bohatá J, Pavelka K, Pavlíková M, Suzuki H, Matsuo H, Takada T, Stiburkova B. Functional Characterization of Clinically-Relevant Rare Variants in ABCG2 Identified in a Gout and Hyperuricemia Cohort. Cells 2019 8(4):363. [open access]
  • Uchida S, Asai Y, Kariya Y, Tsumoto K, Hibino H, Honma M, Abe T, Nin F, Kurata Y, Furutani K, Suzuki H, Kitano H, Inoue R, Kurachi Y. Integrative and theoretical research on the architecture of a biological system and its disorder. J Physiol Sci. 2019 69(3):433-451. [open access]
  • Malhotra P, Soni V, Yamanashi Y, Takada T, Suzuki H, Gill RK, Saksena S, Dudeja PK, Alrefai WA. Mechanisms of Niemann Pick type C1 Like 1 Protein Degradation in Intestinal Epithelial Cells. Am J Physiol Cell Physiol. 2019 316(4):C559-C566. [abstract]
  • Toyoda Y, Takada T, Suzuki H. Inhibitors of human ABCG2: from technical background to recent updates with clinical implications. Front Pharmacol. 2019 10:208. [open access]
  • Toyoda Y, Takada T, Umezawa M, Tomura F, Yamanashi Y, Takeda K, Suzuki H. Identification of hepatic NPC1L1 as an NAFLD risk factor evidenced by ezetimibe-mediated steatosis prevention and recovery. FASEB BioAdvances 2019 1(5):283-295. [open access]
  • Ishida T, Tokuda K, Hisaka A, Honma M, Kijima S, Takatoku H, Iwatsubo T, Moritoyo T, Suzuki H. The Alzheimer's Disease Neuroimaging Initiative. A Novel Method to Estimate Long-term Chronological Changes from Fragmented Observations in Disease Progression. Clin Pharmacol Ther. 2019 105(2):436-447 [abstract]
  • Sone E, Noshiro D, Ikebuchi Y, Nakagawa M, Khan M, Tamura Y, Ikeda M, Oki M, Murali R, Fujimori T, Yoda T, Honma M, Suzuki H, Ando T, Aoki K. The induction of RANKL molecule clustering could stimulate early osteoblast differentiation. Biochem Biophys Res Commun. 2019 509(2):435-440. [abstract]
  • Ito SM, Yamanashi Y, Takada T, Suzuki H. Clinical Importance of Drug-Drug Interaction Between Warfarin and Prednisolone and Its Potential Mechanism in Relation to the Niemann-Pick C1-Like 1-Mediated Pathway. Circ J. 2019 83(2):471-480. [abstract]