研究業績 2013年

  • Kariya Y, Honma M, Suzuki H. Systems-based understanding of pharmacological responses with combinations of multidisciplinary methodologies. Biopharm Drug Dispos. 2013 Dec;34(9):489-507. [abstract]

  • Nukui Y, Hatakeyama S, Okamoto K, Yamamoto T, Hisaka A, Suzuki H, Yata N, Yotsuyanagi H, Moriya K. High plasma linezolid concentration and impaired renal function affect development of linezolid-induced thrombocytopenia. J Antimicrob Chemother. 2013 Sep;68(9):2128-33. [abstract]

  • Nakayama A, Matsuo H, Shimizu T, Ogata H, Takada Y, Nakashima H, Nakamura T, Shimizu S, Chiba T, Sakiyama M, Ushiyama C, Takada T, Inoue K, Kawai S, Hishida A, Wakai K, Hamajima N, Ichida K, Sakurai Y, Kato Y, Shimizu T, Shinomiya N. A common missense variant of monocarboxylate transporter 9 (MCT9/SLC16A9) gene is associated with renal overload gout, but not with all gout susceptibility. Hum Cell. 2013 Dec;26(4):133-6. [abstract]

  • Matsuo H, Ichida K, Takada T, Nakayama A, Nakashima H, Nakamura T, Kawamura Y, Takada Y, Yamamoto K, Inoue H, Oikawa Y, Naito M, Hishida A, Wakai K, Okada C, Shimizu S, Sakiyama M, Chiba T, Ogata H, Niwa K, Hosoyamada M, Mori A, Hamajima N, Suzuki H, Kanai Y, Sakurai Y, Hosoya T, Shimizu T, Shinomiya N. Common dysfunctional variants in ABCG2 are a major cause of early-onset gout. Sci. Rep. 2013 Jun 18;3:2014. [abstract] [プレスリリース]

  • Yamashita F, Sasa Y, Yoshida S, Hisaka A, Asai Y, Kitano H, Hashida S, Suzuki H.  Modeling of Rifampicin-Induced CYP3A4 Activation Dynamics for the Prediction of Clinical Drug-Drug Interactions from In Vitro Data. PLoS One. 2013 Sep 24:8(9):e70330. [abstract]  

  • Ito N, Ito K, Koshimichi H, Hisaka A, Honma M, Igarashi T, Suzuki H. Contribution of protein binding, lipid partitioning, and asymmetrical transport to drug transfer into milk in mouse versus human.   Pharm Res. Sep;30(9):2410-22. [abstract]  

  • Honma M, Ikebuchi Y, Kariya Y, Hayashi M, Hayashi N, Aoki S, Suzuki H. RANKL subcellular trafficking and regulatory mechanisms in osteocytes.  J Bone Miner Res 2013 Sep;28(9):1936-49. [abstract]  [論文中の図が表紙に採択]

  • Takeuchi K, Ohishi M, Ota S, Suzumura K, Naraoka H, Ohata T, Seki J, Miyamae Y, Honma M, Soga T.  Metabolic Profiling to Identify Potential Serum Biomarkers for Gastric Ulceration Induced by Nonsteroid Anti-Inflammatory Drugs.  J Proteome Res. 2013 Mar 1;12(3):1399-407 [abstract]  

  • Yoshikado T, Takada T, Yamamoto H, Tan JK, Ito K, Santa T, Suzuki H.  Ticlopidine, a Cholestatic Liver Injury-Inducible Drug, Causes Dysfunction of Bile Formation via Diminished Biliary Secretion of Phospholipids: Involvement of Biliary-Excreted Glutathione-Conjugated Ticlopidine Metabolites.  Mol Pharmacol. 83(2):552-62. (2013) [abstract]

  • Ito M, Yamanashi Y, Toyoda Y, Izumi-Nakaseko H, Osa S, Sugiyama A, Kuroda M, Suzuki H, Takada T, Adachi-Akahane S.  Disruption of Stard10 gene alters the PPARα-mediated bile acid homeostasis.  Biochim Biophys Acta. 1831(2):459-68. (2013) [abstract]
  • Kudo T, Hisaka A, Sugiyama Y, Ito K.  Analysis of the repaglinide concentration increase produced by gemfibrozil and itraconazole based on the inhibition of the hepatic uptake transporter and metabolic enzymes.  Drug Metab Dispos. 41(2):362-71. (2013) [abstract]