研究業績 2015年

  • Furukawa J, Inoue K, Maeda J, Yasujima T, Ohta K, Kanai Y, Takada T, Matsuo H, Yuasa H. Functional identification of SLC43A3 as an equilibrative nucleobase transporter involved in purine salvage in mammals. Sci Rep. 2015 Oct 12;5:15057. [abstract]

  • Amemiya T, Honma M, Kariya Y, Ghosh S, Kitano H, Kurachi Y, Fujita KI, Sasaki Y, Honma Y, Abernethy DR, Kume H, Suzuki H.  Elucidation of the molecular mechanisms underlying adverse reactions associated with a kinase inhibitor using systems toxicology.  npj Systems Biology and Applications 2015 1:15005. [Open access]

  • Takada T, Yamanashi Y, Konishi K, Yamamoto T, Toyoda Y, Masuo Y, Yamamoto H, Suzuki H. NPC1L1 is a key regulator of intestinal vitamin K absorption and a modulator of warfarin therapy. Science Translational Medicine. 2015 Feb 18;7(275):275ra23. [abstract] [論文DL[プレスリリース] [Clin Pharmacl Ther誌のHighlightsで紹介されました][UTokyo Research] [Japanese Scientists in Science Translational Medicine]

  • Ito N, Ito K, Ikebuchi Y, Toyoda Y, Takada T, Hisaka A, Oka A, Suzuki H. Prediction of Drug Transfer into Milk Considering Breast Cancer Resistance Protein (BCRP)-Mediated Transport. Pharm Res. 2015 Aug;32(8):2527-37. [abstract]

  • Chiba T, Matsuo H, Kawamura Y, Nagamori S, Nishiyama T, Wei L, Nakayama A, Nakamura T, Sakiyama M, Takada T, Taketani Y, Suma S, Naito M, Oda T, Kumagai H, Moriyama Y, Ichida K, Shimizu T, Kanai Y, Shinomiya N. NPT1/SLC17A1 Is a Renal Urate Exporter in Humans and Its Common Gain-of-function Variant Decreases the Risk of Renal Underexcretion Gout. Arthritis Rheumatol. 2015 Jan;67(1):281-7. [abstract]

  • Ando H, Hisaka A, Suzuki H.  A New Physiologically-Based Pharmacokinetic Model for the Prediction of Gastrointestinal Drug Absorption: Translocation Model.  Drug Metab Dispos. 2015 Apr;43(4):590-602. [abstract]

  • Shirota K, Kaneko M, Sasaki M, Minato K, Fujikata A, Ohta S, Hisaka A, Suzuki H. Analysis of the Disposition of a Novel p38 MAPK Inhibitor, AKP-001, and its Metabolites in Rats with a Simple Physiologically Based Pharmacokinetic Model. Drug Metab Dispos. 2015 Feb;43(2):217-26. [abstract]