生体感染制御グループ(130研究室)

研究室紹介
130研究室は感染症内科が設立された際にできた研究室です。森澤雄司先生(現自治医科大学感染制御部部長)が初代室長でした。臨床・研究のバックグランドは様々ですが、臨床感染症が大好きであると同時に、教育へのパッションとリサーチマインドを共有するメンバーが集まっているのが特徴です。
メンバー
現メンバーは、原田壮平、岡本耕、橋本英樹、十菱大介、篠原孝幸の5名です。

原田は、国立国際医療研究センター病院、聖路加国際病院で臨床感染症のトレーニングを積み、がん研有明病院では感染症科・院内感染対策部を新設し、藤田医科大学病院では、感染症科の立ち上げに関わりました。研究面では、主に多剤耐性グラム陰性桿菌や高病原性肺炎桿菌を対象に、臨床で生じる疫学的、病態生理的疑問点の解決に向けて臨床分離株の微生物学的・分子生物学的解析を行っています(PMID: 29678299, 29311089, 22327516, 22106217, 20566768)。高病原性肺炎桿菌については、国内多施設からの重症症例の菌株解析依頼に対応するほか(PMID: 34088602, 33320080, 33008737)、多施設研究を主導し、日本における肺炎桿菌血流感染症の臨床像と分子疫学を明らかにしました(PMID: 31434721)。また、近年はがん患者の感染症に関する臨床研究・臨床微生物研究にも取り組んでいます(PMID: 31999762, 31787529, 33752612)。

岡本は、米国で内科レジデンシーおよび感染症フェローシップを修了し、現在は医局長として固形臓器移植などの免疫不全患者をはじめとする感染症コンサルテーションの中心を担っております。研究面では、CDCエピセンタープログラム(https://www.cdc.gov/hai/epicenters/chicago.html)の基幹施設での医療疫学フェロー時代に臨床研究に従事し、以来耐性菌の院内伝播およびその防止の方策に関する医療疫学研究に取り組んできました(PMID: 30891093、28987641、32265107、32505135)。また、近年は、臨床診療でぶつかった問題に取り組む固形移植臓器患者などの免疫不全患者の感染症の予防・診療の質改善のための研究も行っています(PMID: 33208510, 34074999, 32265107、31481306)。

橋本は、東京山手メディカルセンター、東大病院で感染症診療および総合内科・救急集中治療のトレーニングを積み、日立総合病院では救急集中治療科で重症患者診療を行いながら、感染症科を立ち上げて院内の感染症コンサルテーションや感染対策業務に従事しました。研究面では抗菌薬適正使用を主なテーマとし、集中治療領域における抗菌薬適正使用についての臨床研究や(PMID: 32717914)、レセプトなどのビッグデータを用いて抗菌薬処方動向やインフルエンザについての疫学研究を行っています(PMID: 30948598、31730926)。近年では日本版敗血症診療ガイドライン2020特別委員会のメンバーとして、敗血症やCOVID-19に関するガイドラインの作成に携わっています。

十菱は、東大病院と東京都済生会中央病院で感染症および一般内科診療のトレーニングを積み、大学院在籍中は東京大学医科学研究所のウイルス感染分野で、臨床検体を用いたインフルエンザウイルスの抗原性の変化の解析を行いました。現在は主にコンサルテーションチームの一員として感染症診療に携わっており、新型コロナウイルスワクチン接種後の抗体価の研究を進めています。

篠原は、虎の門病院、関東中央病院で循環器内科の研修を積み、卒後10年間は循環器内科医として心不全治療、カテーテル治療に従事してきました。現在は国立感染症研究所の研究員としてカンジダ属の病原性の研究や、研究所に依頼を受けた検体の真菌同定・薬剤感受性試験などを行っています。

OB/OGも、インフルエンザウイルス、フラビウイルスや肝炎ウイルスなどの基礎研究、そしてタイのマラリア患者(英国・オックスフォード大)や日本のレセプトを使った疫学研究などバックグランドとする分野は様々でした。現在は、大学病院・市中病院の臨床感染症・感染制御・感染症教育の中心を担っておられる先生から、在宅医療で奮闘されている先生、感染症の数理モデルの研究をされている先生まで様々な分野でご活躍中です。
感染症診療について
感染症内科では、HIV感染症、抗酸菌感染症、輸入感染症、不明熱などについては主治医として診療にあたります。また、院内すべての診療科からのコンサルテーションを受け、主治医とともに患者さんの診療を行います。比較的コモンな疾患から、大学病院の特殊性を反映した固形臓器・造血幹細胞移植後感染症などの幅広い疾患を扱いますが、ミクロ(微生物)からマクロ(疫学)まで感染症医としての専門性を生かしながら、内科医としての視点も大切にして総合的に全身のマネージメントをすることを目標に診療にあたっています。
感染管理・感染制御について
当研究室は、感染制御の分野(病院感染症対策、病院感染症サーベイランスおよび介入)にも力を入れてきた経緯があり、現在も原田が感染制御部講師として院内の感染管理の中心を担っております。また、岡本、十菱が抗菌薬適正使用チームの一員として活動中です。
臨床感染症教育について
森澤先生、前室長の畠山修司先生(現自治医科大学総合診療科・感染症科教授)が在籍されていた時代より教育へのパッションは一貫しており、臨床感染症教育も研究室として大切にしているミッションの一つと考えております。感染症内科では、感染症指導医を中心に、複数の感染症専門研修医から直接指導を受けることができる屋根瓦式の教育指導体制を充実させており、多くの初期研修医や医学部学生の教育も担っています。特に、ベッドサイドでの症例提示・ディスカッション、症例から生じる疑問からの文献検索および学びの共有を大事にしております。近年は岡本、十菱が臨床教育部員として教育の中心を担っており、医学部生によって選ばれる臨床実習ベスト診療科賞を毎年受賞しております(2018年度第1位)。また、岡本は医学生教育に対して医学部Best Teacher's award(2019年)、研修医教育に対して優秀指導医賞(2016年、2019年、2020年)を受賞しております。また研修医の症例報告の学会発表、論文指導(PMID: 30738726)も積極的に行っております。
研究について
私たちの研究室の目標の一つとして「リサーチマインドを持った感染症内科医の育成」を掲げています。臨床に直結するリサーチをコンセプトに、研究にも力をいれています。微生物の薬剤耐性メカニズムを中心に、さまざまなウイルスや細菌の研究を学外の研究室と共同で進めています。また、医療の質改善を図る臨床研究や臨床疫学研究も今後さらに積極的に実施したいと思っています。
連絡先
私たち感染症内科130研究室は、アカデミックな環境を基盤とした臨床やリサーチに、ともにチャレンジしてくれる方を歓迎します! 感染症内科での研修や、当研究室に関してご質問・ご相談がある方は、下記にご連絡ください。

岡本耕 (おかもと こう)(kokamoto-tky(アットマーク)umin.ac.jp)
 
在籍メンバーの発表論文(2004年以降)
2021年
Amano Y, Kage H, Tanaka G, Gonoi W, Nakai Y, Kurokawa R, Inui S, Okamoto K, Harada S, Iwabu M, Morizaki Y, Abe O, Moriya K, Nagase T. Diagnostic prediction of COVID-19 based on clinical and radiological findings in a relatively low COVID-19 prevalence area.Respir Investig. 2021 Jul;59(4):446-453. PMID: 33865743

Harada S, Aoki K, Ohkushi D, Okamoto K, Takehana K, Akatsuchi T, Ida K, Shoji D, Ishii Y, Doi Y, Moriya K, Hayama B. Institutional outbreak involving multiple clades of IMP-producing Enterobacter cloacae complex sequence type 78 at a cancer center in Tokyo, Japan. BMC Infect Dis. 2021 Mar 22;21(1):289. PMID: 33752612

Hosoda T, Harada S, Okamoto K, Ishino S, Kaneko M, Suzuki M, Ito R, Mizoguchi M. COVID-19 and Fatal Sepsis Caused by Hypervirulent Klebsiella pneumoniae, Japan, 2020. Emerg Infect Dis. 2021 Feb;27(2):556-559. PMID: 33320080

Ikeda M, Wakabayashi Y, Okamoto K, Yanagimoto S, Okugawa S, Moriya K. Changing trends in lipid profile and biomarkers of renal function and bone metabolism before and after switching from tenofovir disoproxil fumarate to tenofovir alafenamide: a prospective observational study. AIDS Res Ther. 2021 May 27;18(1):30. PMID: 34044856

Ikeuchi K, Okamoto K, Inoue N, Okugawa S, Moriya K. Chronic Disseminated Gonococcal Infection in a Japanese Man with Novel C5 Gene Mutation. J Clin Immunol. 2021 Apr;41(3):691-693. PMID: 33403467

Kanda N, Okamoto K, Okumura H, Mieno M, Sakashita K, Sasahara T, Hatakeyama S. Outcomes associated with treatment change from tenofovir disoproxil fumarate to tenofovir alafenamide in HIV-1-infected patients: a real-world study in Japan.HIV Med. 2021 Jul;22(6):457-466. PMID: 33720508

Kitaura S, Okamoto K. Microbial-disease Correlation: Time to Focus on Post-Koch's Criteria? Clin Infect Dis. 2021 May 18;72(10):e692. PMID: 32909040

Kobayashi T, Nakajima K, Oshima Y, Ikeda M, Kitaura S, Ikeuchi K, Okamoto K, Okada Y, Ohama Y, Higurashi Y, Okugawa S, Moriya K. First Reported Human Case of Spondylodiscitis by Staphylococcus condimenti: A Case Report and Literature Review. Intern Med. 2021 Feb 15;60(4):635-637. PMID: 33028768

Kubota Y, Ishioka H, Harada S, Suzuki M, Shiotsuka J, Lefor AK, Sanui M. Septic shock with emphysematous cholecystitis and disseminated infection caused by hypervirulent Klebsiella pneumoniae capsular genotype K2-ST65 in a Japanese man with diabetes mellitus: A case report.J Infect Chemother. 2021 Feb;27(2):350-353. PMID: 33008737

Mizoguchi M, Harada S, Okamoto K, Higurashi Y, Ikeda M, Moriya K. Comparative performance and cycle threshold values of 10 nucleic acid amplification tests for SARS-CoV-2 on clinical samples.PLoS One. 2021 Jun 23;16(6):e0252757. PMID: 34161355

Nakamura K, Nomoto H, Harada S, Suzuki M, Yomono K, Yokochi R, Hagino N, Nakamoto T, Moriyama Y, Yamamoto K, Kutsuna S, Ohmagari N. Infection with capsular genotype K1-ST23 hypervirulent Klebsiella pneumoniae isolates in Japan after a stay in East Asia: Two cases and a literature review.J Infect Chemother. 2021 Jun 1:S1341-321X(21)00140-9. PMID: 34088602

Nakamura K, Takahashi Y, Sonoo T, Hashimoto H. Intravenous Immunoglobulin for Overwhelming Postsplenectomy Infection. J Glob Infect Dis. 2021 Jan 29;13(1):44-51. PMID: 33911454

Nakano H, Hashimoto H, Mochizuki M, Naraba H, Takahashi Y, Sonoo T, Matsubara T, Yamakawa K, Nakamura K. Urine Titin N-Fragment as a Biomarker of Muscle Injury for Critical Illness Myopathy.Am J Respir Crit Care Med. 2021 Feb 15;203(4):515-518. PMID: 33030965

Okamoto K, Yamada N, Suzuki T, Muramatsu T, Uemura H, Gatanaga H, Kato T, Hatakeyama S. Emergence of hepatitis C virus genotype 2c infection among human immunodeficiency virus-infected men who have sex with men in Tokyo, Japan. Sex Transm Dis. 2021 Jun 1. PMID: 34074999

Okushin K, Suzuki R, Tsutsumi T, Okamoto K, Ikeuchi K, Kado A, Minatsuki C, Minami-Kobayashi Y, Satoh N, Ikeda M, Harada S, Enooku K, Fujinaga H, Yotsuyanagi H, Koike K, Moriya K. Change in hepatitis C virus positivity among needle-stick injury source patients: a 10-year experience in a Japanese tertiary hospital.BMC Infect Dis. 2021 Apr 30;21(1):399. PMID: 33931015

Osawa I, Okamoto K, Ikeda M, Otani A, Wakimoto Y, Yamashita M, Shinohara T, Kanno Y, Jubishi D, Kurano M, Harada S, Okugawa S, Yatomi Y, Moriya K. Dynamic changes in fibrinogen and D-dimer levels in COVID-19 patients on nafamostat mesylate.J Thromb Thrombolysis. 2021 Apr;51(3):649-656. PMID: 32920751

Popovich KJ, Green SJ, Okamoto K, Rhee Y, Hayden MK, Schoeny M, Snitkin ES, Weinstein RA. MRSA Transmission in Intensive Care Units: Genomic Analysis of Patients, Their Environments, and Healthcare Workers. Clin Infect Dis. 2021 Jun 1;72(11):1879-1887. PMID: 32505135

Shimura T, Kurano M, Kanno Y, Ikeda M, Okamoto K, Jubishi D, Harada S, Okugawa S, Moriya K, Yatomi Y. Clot waveform of APTT has abnormal patterns in subjects with COVID-19. Sci Rep. 2021 Mar 4;11(1):5190. PMID: 33664450

Yamamoto S, Ikeda M, Kanno Y, Okamoto K, Okugawa S, Moriya K. Microbiological analysis of infectious lymphocele: Case series and literature review. J Infect Chemother. 2021 Feb;27(2):172-178. PMID: 32900660

2020年
Doi K, Ikeda M, Hayase N, Moriya K, Morimura N; COVID-UTH Study Group. Nafamostat mesylate treatment in combination with favipiravir for patients critically ill with Covid-19: a case series. Crit Care. 2020 Jul 3;24(1):392. PMID: 32620147

Futatsugi H, Iwabu M, Okada-Iwabu M, Okamoto K, Amano Y, Morizaki Y, Kadowaki T, Yamauchi T. Blood Glucose Control Strategy for Type 2 Diabetes Patients With COVID-19. Front Cardiovasc Med. 2020 Oct 28;7:593061. PMID: 33195481

Harada S, Shibue Y, Aoki K, Ishii Y, Tateda K: Prevalence of high-level aminoglycoside resistance and genes encoding aminoglycoside-modifying enzymes in Enterococcus faecalis and Enterococcus faecium isolated in a university hospital in Tokyo. Jpn J Infect Dis. 2020 (in press)

Harada S, Ohkushi D, Nakano K, Mitani H, Yamamoto Y, Kamei K, Hayama B. Fatal invasive pulmonary aspergillosis caused by voriconazole-resistant Aspergillus tubingensis in a patient with solid tumor. J Infect Chemother. 2020;26(3):301-304. PMID: 31787529.

Hashimoto H, Saito M, Sato J, Goda K, Mitsutake N, Kitsuregawa M, Nagai R, Hatakeyama S. Indications and classes of outpatient antibiotic prescriptions in Japan: A descriptive study using the national database of electronic health insurance claims, 2012–2015. Int J Infect Dis. 2020; 91: 1-8. PMID: 31730926

Imai M, Yamashita M, Sakai-Tagawa Y, Iwatsuki-Horimoto K, Kiso M, Murakami J, Yasuhara A, Takada K, Ito M, Nakajima N, Takahashi K, Lopes TJS, Dutta J, Khan Z, Kriti D, van Bakel H, Tokita A, Hagiwara H, Izumida N, Kuroki H, Nishino T, Wada N, Koga M, Adachi E, Jubishi D, Hasegawa H, Kawaoka Y. Influenza A variants with reduced susceptibility to baloxavir isolated from Japanese patients are fit and transmit through respiratory droplets. Nat Microbiol. 2020 Jan;5(1):27-33. Epub 2019 Nov 25. PMID: 31768027

Ishihara Y, Okamoto K, Shimosaka H, Ono Y, Kanno Y, Ikeda M, Harada S, Kurano M, Okugawa S, Moriya K, Yatomi Y.Prevalence and clinical characteristics of patients with biologically false-positive reactions with serological syphilis testing in contemporary practice: 10-year experience at a tertiary academic hospital. Sex Transm Infect. 2020 Nov 18:sextrans-2020-054628. PMID: 33208510

Kanda N, Hashimoto H, Sonoo T, Naraba H, Takahashi Y, Nakamura K, Hatakeyama S.Gram-negative Organisms from Patients with Community-Acquired Urinary Tract Infections and Associated Risk Factors for Antimicrobial Resistance: A Single-Center Retrospective Observational Study in Japan. Antibiotics (Basel). 2020 Jul 23;9(8):438. PMID: 32717914

Kato-Miyashita S, Sakai-Tagawa Y, Yamashita M, Iwatsuki-Horimoto K, Ito M, Tokita A, Hagiwara H, Izumida N, Nishino T, Wada N, Koga M, Adachi E, Jubishi D, Yotsuyanagi H, Kawaoka Y, Imai M. Antigenic variants of influenza B viruses isolated in Japan during the 2017-2018 and 2018-2019 influenza seasons. Influenza Other Respir Viruses. 2020 May;14(3):311-319. Epub 2020 Jan 19. PMID: 31955521

Kitaura S, Wakabayashi Y, Okazaki A, Okada Y, Okamoto K, Ikeda M, Okugawa S, Moriya K. The First Case Report of Acute Symptomatic HEV Genotype 4 Infection in an HIV-positive Patient in Japan. Intern Med. 2020 Jul 1;59(13):1655-1658. PMID: 32269193

Kitaura S, Okamoto K, Wakabayashi Y, Okada Y, Okazaki A, Ikeda M, Hakuta R, Nakai Y, Okugawa S, Koike K, Moriya K. Vibrio fluvialis Liver Abscess and Bacteremia in a Sashimi Lover: A Case Report and Review of the Literature. Open Forum Infect Dis. 2020 Jun 6;7(6):ofaa212.PMID: 32587879


Nakamura K, Ogura K, Nakano H, Naraba H, Takahashi Y, Sonoo T, Hashimoto H, Morimura N. C-reactive protein clustering to clarify persistent inflammation, immunosuppression and catabolism syndrome. Intensive Care Med. 2020 Mar;46(3):437-443. PMID: 31919541

Nakano H, Hashimoto H, Mochizuki M, Naraba H, Takahashi Y, Sonoo T, Nakamura K. Hypoalbuminemia on Admission as an Independent Risk Factor for Acute Functional Decline after Infection. Nutrients. 2020 Dec 23;13(1):26. PMID: 33374807

Okamoto K, Asano S, Yamamoto T, Toyono T, Yamaguchi R, Okada Y, Okugawa S, Suzuki H, Moriya K, Aihara M. Poor penetration of cefcapene into aqueous humor after oral administration of cefcapene pivoxil to patients undergoing cataract surgery. J Infect Chemother. 2020 Feb;26(2):312-315. PMID: 31481306

Okamoto K, Ayibieke A, Saito R, Ogura K, Magara Y, Ueda R, Ogawa H, Hatakeyama S. A nosocomial cluster of Roseomonas mucosa bacteremia possibly linked to contaminated hospital environment. J Infect Chemother. 2020 Aug;26(8):802-806. PMID: 32265107

Okamoto K, Santos CAQ. Management and prophylaxis of bacterial and mycobacterial infections among lung transplant recipients. Ann Transl Med. 2020 Mar;8(6):413. PMID: 32355857

Sasaki T, Harada S, Yamamoto S, Ohkushi D, Hayama B, Takeda K, Hoashi K, Shiotani J, Takehana K, Doi Y. Clinical characteristics of peripheral venous catheter-associated gram-negative bloodstream infection among patients with malignancy. PLoS One. 2020;15(1):e0228396. PMID: 31999762

Shinohara T, Otani A, Yamashita M, Wakimoto Y, Jubishi D, Okamoto K, Kanno Y, Ikeda M, Ishigaki K, Nakai Y, Harada S, Okugawa S, Koike K, Moriya K. Acute Pancreatitis During COVID-19 Pneumonia. Pancreas. 2020 Nov/Dec;49(10):e106-e108. PMID: 33122537

Yamamoto S, Okamoto K. Blood Culture Results Before and After Antimicrobial Administration. Ann Intern Med. 2020 Mar 17;172(6):440. PMID: 32176902

Yoshimura J, Hashimoto H, Yamakawa K. Antibiotic stewardship in critically ill patients with suspected ventilator-associated pneumonia. Ann Transl Med. 2020 Oct;8(20):1329. PMID: 33209909

2019年
Chlipala GE, Lei ZA, Maienschein-Cline M, Kunstman K, Okamoto K, Green SJ, Popovich KJ. Complete Genome Sequence of a USA100 Methicillin-Resistant Staphylococcus aureus Strain. Microbiol Resour Announc. 2019;8(11). PMID: 30938319

Harada S, Aoki K, Okamoto K, Kinoshita O, Nawata K, Ishii Y, Tateda K, Sasaki M, Saga T, Doi Y, Yotsuyanagi H, Moriya K, Ono M. Left ventricular assist device-associated endocarditis involving multiple clones of Staphylococcus aureus with distinct antimicrobial susceptibility patterns. Int J Infect Dis. 2019;84:44-47. PMID: 31075509

Hashimoto H, Matsui H, Sasabuchi Y Yasunaga H, Kotani K, Nagai R, Hatakeyama S. Antibiotic prescription among outpatients in a prefecture of Japan, 2012-2013: a retrospective claims database study. BMJ Open. 2019;9(4): e026251. PMID: 30948598

Hatakeyama S, Okamoto K, Ogura K, Sugita C, Nagi M. Histoplasmosis among HIV-infected patients in Japan: A case report and literature review. Jpn J Infect Dis. 2019 Apr 26. doi: 10.7883/yoken.JJID.2018.354. PMID: 31061355

Hau TTT, Nakamura-Hoshi M, Kanno Y, Nomura T, Nishizawa M, Seki S, Ishii H, Kawana-Tachikawa A, Hall WW, Nguyen Thi LA, Matano T, Yamamoto H: CD8+ T cell-based strong selective pressure on multiple simianimmunodeficiency virus targets in macaques possessing a protectiveMHC class I haplotype. Biochem Biophys Res Commun. 2019 Apr 30;512(2):213-217. PMID: 30878187

Kanda N, Takeda K, Hatakeyama S, Matsumura M. Ankylosing spondylitis presenting with enthesitis at an uncommon site and fever of unknown origin. BMJ Case Rep. 2019;12(8). PMID: 31401572

Miyashita H, Okamoto K, Kobayashi T, Wakabayashi Y, Kitaura S, Ikeuchi K, Ishigaki K, Nakai Y, Okugawa S, Koike K, Moriya K. Bacterial peritonitis in a patient with malignant ascites caused by pancreatic carcinoma: Case report and review of literature. J Infect Chemother. 2019;25(6):473-476. PMID: 30738726

Nakamura K, Inokuchi R, Fukushima K, Naraba H, Takahashi Y, Sonoo T, Hashimoto H, Doi K, Morimura N. Single versus divided administration of intravenous immunoglobulin for sepsis: a retrospective and historical control study. Minerva Anestesiol. 2019 Feb;85(2):156-163.PMID: 29808971

Okamoto K, Rhee Y, Schoeny M, Lolans K, Cheng J, Reddy S, Weinstein RA, Hayden MK, Popovich KJ; Centers for Disease Control and Prevention Epicenters Program. Impact of doffing errors on healthcare worker self-contamination when caring for patients on contact precautions. Infect Control Hosp Epidemiol. 2019;40(5):559-565. PMID: 30890193

Ruchlemer R, Ben-Ami R, Bar-Meir M, Brown JR, Malphettes M, Mous R, Tonino SH, Soussain C, Barzic N, Messina JA, Jain P, Cohen R, Hill B, Mulligan SP, Nijland M, Herishanu Y, Benjamini O, Tadmor T, Okamoto K, Arthurs B, Gottesman B, Kater AP, Talha M, Eichhorst B, Korem M, Bogot N, De Boer F, Rowe JM, Lachish T. Ibrutinib-associated invasive fungal diseases in patients with chronic lymphocytic leukaemia and non-Hodgkin lymphoma: An observational study. Mycoses. 2019;62(12):1140-1147. PMID: 31520441

Saito M, Mansoor R, Kennon K, McGready R, Nosten F, Guérin PJ, Stepniewska K. The efficacy of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy: a protocol for systematic review and individual patient data (IPD) meta-analysis. BMJ Open. 2019;9:e027503

Saito M, Mansoor R, Wiladphaingern J, Paw MK, Pimanpanarak M, Proux S, et al. Optimal Duration of Follow-up for Assessing Antimalarial Efficacy in Pregnancy: A Retrospective Analysis of a Cohort Followed Up Until Delivery on the Thailand–Myanmar Border. Open Forum Infect Dis. 2019;6(7): ofz264. PMID: 31281861

Shimasaki T, Seekatz A, Bassis C, Rhee Y, Yelin RD, Fogg L, Dangana T, Cisneros EC, Weinstein RA, Okamoto K, Lolans K, Schoeny M, Lin MY, Moore NM, Young VB, Hayden MK; Centers for Disease Control and Prevention Epicenters Program. Increased Relative Abundance of Klebsiella pneumoniae Carbapenemase-producing Klebsiella pneumoniae Within the Gut Microbiota Is Associated With Risk of Bloodstream Infection in Long-term Acute Care Hospital Patients. Clin Infect Dis. 2019;68(12):2053-2059. PMID: 30239622

Takahashi Y, Sonoo T, Naraba H, Hashimoto H, Nakamura K. Effect of Intra-arterial Balloon Pumping for Refractory Septic Cardiomyopathy: A Case Series. Indian J Crit Care Med. 2019 Apr;23(4):182-185. PMID: 31130790

Yamamoto S, Okamoto K, Okugawa S, Moriya K. Fusobacterium necrophorum septic pelvic thrombophlebitis after intrauterine device insertion. Int J Gynaecol Obstet. 2019;145(1):122-123. PMID: 30648745

Wakabayashi Y, Jubishi D, Okamoto K, Ikeda M, Tatsuno K, Mizoguchi M, Sato T, Okugawa S, Moriya K. A rare case of a prostatic abscess, bacteremia and chronic granulomatous disease associated with Klebsiella pneumoniae. J Infect Chemother. 2019;25(5):365-367. PMID: 30642769


2018年
Kanno Y, Wakabayashi Y, Ikeda M, Tatsuno K, Misawa Y, Sato T, Yanagimoto S, Okugawa S, Moriya K, Yotsuyanagi H. Catheter-related bloodstream infection caused by Kodamaea ohmeri: A case report and literature review. J Infect Chemother. 2017;23(6):410-414. PMID: 28188094

Hashimoto H, Saito M, Kanda N, Yamamoto T, Mieno M, Hatakeyama S. Dose-dependent effect of daptomycin on the artificial prolongation of prothrombin time in coagulation abnormalities: in vitro verification. BMC Pharmacol Toxicol. 2017; 18: 74. PMID: 29179737

Okamoto K, Hatakeyama S. Tuberculous Peritonitis. N Engl J Med. 2018;379(12):e20. PMID: 30231225

Okamoto K, Hatakeyama S, Sugita C, Ogura K, Ueda R, Kouda H, Nakata J. Nasal diphtheria (chronic carriage) caused by nontoxigenic Corynebacterium diphtheriae. J Infect Chemother. 2018 Sep;24(9):759-762. PMID: 29487033

Okamoto K, Hatakeyama S, Umezawa M, Hayashi S. Gastric syphilis: The great imitator in the stomach. IDCases. 2018 Mar 21;12:97-98. PMID: 29942761

Rhee Y, Palmer LJ, Okamoto K, Gemunden S, Hammouda K, Kemble SK, Lin MY, Lolans K, Fogg L, Guanaga D, Yokoe DS, Weinstein RA, Frendl G, Hayden MK; Centers for Disease Control and Prevention Epicenter Program. Differential Effects of Chlorhexidine Skin Cleansing Methods on Residual Chlorhexidine Skin Concentrations and Bacterial Recovery. Infect Control Hosp Epidemiol. 2018 Apr;39(4):405-411. PMID: 29493475

Okamoto K, Rhee Y, Schoeny M, Lolans K, Cheng J, Reddy S, Weinstein RA, Hayden MK, Popovich KJ; Centers for Disease Control and Prevention Epicenters Program. Flocked nylon swabs versus RODAC plates for detection of multidrug-resistant organisms on environmental surfaces in intensive care units. J Hosp Infect. 2018 Jan;98(1):105-108. PMID: 28987641

Okamoto K, Lin MY, Haverkate M, Lolans K, Moore NM, Weiner S, Lyles RD, Blom D, Rhee Y, Kemble S, Fogg L, Hines DW, Weinstein RA, Hayden MK. Modifiable Risk Factors for the Spread of Klebsiella pneumoniae Carbapenemase-Producing Enterobacteriaceae Among Long-Term Acute-Care Hospital Patients. Infect Control Hosp Epidemiol. 2017; 38(6):670-677. PMID: 28397615

Saito M, Gilder ME, McGready R, Nosten F. Antimalarial drugs for treating and preventing malaria in pregnant and lactating women. Expert Opin Drug Saf. 2018;17(11):1129-44 PMID: 30351243

Saito M, Keereevijit A, San TD, Thein YY, Gilder ME, McGready R. Challenges to primary healthcare services in the management of non-communicable diseases in marginalised populations on the Thailand–Myanmar border: a pilot survey. Trop Doct. 2018:004947551878685. (PMID: 30020027)

Saito M, Gilder ME, Nosten F, McGready R, Guérin PJ. Systematic literature review and meta-analysis of the efficacy of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy: methodological challenges. Malar J. 2017;16:488. (PMID: 29237461)

Saito M, Gilder ME, Nosten F, Guérin PJ, McGready R. Methodology of assessment and reporting of safety in anti-malarial treatment efficacy studies of uncomplicated falciparum malaria in pregnancy: a systematic literature review. Malar J. 2017;16:488. (PMID: 29254487)

Saito M, Hatakeyama S, Hashimoto H, Suzuki T, Jubishi D, Kaneko M, et al. Dose-dependent artificial prolongation of prothrombin time by interaction between daptomycin and test reagents in patients receiving warfarin: a prospective in vivo clinical study. Ann Clin Microbiol Antimicrob. 2017;16(1):27. PMID: 28399872

Yamamoto S, Ikeda M, Fujimoto F, Okamoto K, Wakabayashi Y, Sato T, Tatsuno K, Kaburaki T, Yoshida S, Okugawa S, Koike K, Moriya K. Bilateral Candida endophthalmitis accompanying Candida lusitaniae bloodstream infection: A case report. J Infect Chemother. 2018 Feb;24(2):147-149. PMID: 2910234

2016年
Kobayashi T, Nishijima T, Teruya K, et al. High Mortality of Disseminated Non-Tuberculous Mycobacterial Infection in HIV-Infected Patients in the Antiretroviral Therapy Era. PLoS One. 2016 Mar 17;11(3):e0151682.

Kobayashi T, Hayakawa K, Kato Y. A 41-year-old man with fever and dark-coloured urine. J Travel Med. 2016 Mar 19;23(3).

Kobayashi T, Kutsuna S, Hayakawa K, et al. Case Report: An Outbreak of Food-Borne Typhoid Fever Due to Salmonella enterica Serotype Typhi in Japan Reported for the First Time in 16 Years. Am J Trop Med Hyg. 2016 Feb;94(2):289-91.

Okamoto K, Proia LA, Demarais PL. Disseminated Cryptococcal Disease in a Patient with Chronic Lymphocytic Leukemia on Ibrutinib. Case Rep Infect Dis. 2016, Article ID 4642831.

Saito M, Hatakeyama S. Acute Rheumatic Fever with Erythema Marginatum. N Engl J Med, 2016; 375(25): 2480. PMID: 28002702


2015年
Kato-Miyazawa M, Miyoshi-Akiyama T, Kanno Y, Takasaki J, Kirikae T, Kobayashi N: Genetic diversity of Mycobacterium tuberculosis isolates from foreign-born and Japan-born residents in Tokyo. Clin Microbiol Infect. 2015 Mar;21(3):248.e1-8. PMID: 25595707

Saito M, Armstrong M, Boadi S, Lowe P, Chiodini PL, Doherty T. Clinical Features of Imported Loiasis: A Case Series from the Hospital for Tropical Diseases, London. Am. J. Trop. Med. Hyg., 2015; 93(3): 607–11.

Saito M, Hatakeyama S, Wakabayashi Y, Yanagimoto S, Takemura T, Yotsuyanagi H. A pathologically proven case of adult-onset HIV-related lymphocytic interstitial pneumonia with acute exacerbation treated with steroid and antiretroviral therapy. J Infect Chemother, 2015; 21(12):868-72.

Saito M, Armstrong M, Boadi S, Lowe P, Chiodini PL, Doherty T. Clinical Features of Imported Loiasis: A Case Series from the Hospital for Tropical Diseases, London. Am. J. Trop. Med. Hyg., 2015; 93(3): 607–11.

Saito M, Hatakeyama S, Wakabayashi Y, Yanagimoto S, Takemura T, Yotsuyanagi H. A pathologically proven case of adult-onset HIV-related lymphocytic interstitial pneumonia with acute exacerbation treated with steroid and antiretroviral therapy. J Infect Chemother, 2015; 21(12):868-72.

Hashimoto H, Hatakeyama S, Yotsuyanagi H. Development of cryptococcal immune reconstitution inflammatory syndrome 41 months after the initiation of antiretroviral therapy in an AIDS patient. AIDS Res Ther. 2015 Sep 30;12:33.

2014年
Nukui Y, Nakamura H, Ishioka H, Miyamoto H, Okamoto A, Kazumi Y, Yotsuyanagi H, Moriya K, Hatakeyama S. Synovitis of the wrist caused by Mycobacterium florentinum. Infection. 2014;42:437-40.

2013年
Nukui Y, Hatakeyama S, Okamoto K, Yamamoto T, Hisaka A, Suzuki H, Yata N, Yotsuyanagi H, Moriya K. High plasma linezolid concentration and impaired renal function affect development of linezolid-induced thrombocytopenia. J Antimicrob Chemother. 2013;68:2128-33.

Okamoto K, Brown JD. Hepatosplenic schistosomiasis presenting as spontaneous hemoperitoneum in a Filipino immigrant. Am J Med Sci. 2013;346:334-7.

Thomas BS, Okamoto K, Bankowski MJ, Seto TB. A lethalcase of Pseudomonas putida bacteremia due to soft tissue infection. Infect Dis Clin Pract. 2013;21:147-213.

Yamaguchi Y, Nukui Y, Kotaki A, Sawabe K, Saijo M, Watanabe H, Kurane I, Takasaki T, Tajima S. Characterization of a serine-to-asparagine substitution at position 123 in the Japanese encephalitis virus E protein. J Gen Virol. 2013; 94: 90-96.

2012年
Nukui Y, Hatakeyama S, Kitazawa T, Mahira T, Shintani Y, Moriya K. Pandemic 2009 influenza A (H1N1) virus among Japanese healthcare workers: seroprevalence and risk factors. Infect Control Hosp Epidemiol. 2012;33:58-62.

Goto K, Hatakeyama S, Okamoto K, Kitazawa T, Abe K, Moriya K, Koike K,Yotsuyanagi H. Dengue hemorrhagic fever in an adult traveler returning to Japan. Intern Med. 2012;51:1779-82.9.

Saito N, Hida A, Koide Y, Ichikawa Y, Shimizu J, Mukasa A, Nakatomi H, Hatakeyama S,
Ooka T, Hayashi T, Tsuji S. Culture-negative brain abscesses with Streptococcus intermedius infection whose diagnosis was established by direct analysis of 16s ribosomal DNA fragments. Intern Med. 2012;51:211-6.

2011年
Hatakeyama S, Iwatsuki-Horimoto K, Okamoto K, Nukui Y, Yata N, Fujita A, Inaba S, Yotsuyanagi H, Kawaoka Y. Unadjuvanted pandemic H1N1 influenza vaccine in HIV-1-infected adults. Vaccine. 2011;29:9224-8.

Hatakeyama S, Ozawa M, Kawaoka Y. In vitro selection of influenza B viruses with reduced sensitivity to neuraminidase inhibitors. Clin Microbiol Infect. 2011;17:1332-5.

Iwatsuki-Horimoto K, Horimoto T, Tamura D, Kiso M, Kawakami E, Hatakeyama S, Ebihara Y, Koibuchi T, Fujii T, Takahashi K, Shimojima M, Sakai-Tagawa Y, Ito M, Sakabe S, Iwasa A, Takahashi K, Ishii T, Gorai T, Tsuji K, Iwamoto A, Kawaoka Y. Seroprevalence of pandemic 2009 (H1N1) influenza A virus among schoolchildren and their parents in Tokyo, Japan. Clin Vaccine Immunol. 2011;18:860-6.

Nomura M, Shin M, Ohta M, Nukui Y, Ohkusu K, Saito N. Atypical osteomyelitis of the skull base and craniovertebral junction caused by Actinomyces infection. Neurol Med Chir. 2011; 51: 64-66.

Yamaguchi Y, Nukui Y, Tajima S, Nerome R, Kato F, Watanabe H, Takasaki T, Kurane I. An amino acid substitution (V3I) in the Japanese encephalitis virus NS4A protein increases its virulence in mice, but not its growth rate in vitro. J Gen Virol. 2011;92:1601-6.

Ishioka H, Umezawa M, Hatakeyama S. Fulminant amebic colitis in an HIV-infected homosexual man. Intern Med. 2011;50:2851-4.

2010年
Okamoto K, Hatakeyama S, Itoyama S, Nukui Y, Yoshino Y, Kitazawa T, Yotsuyanagi H, Ikeda R, Sugita T, Koike K. Cryptococcus gattii genotype VGIIa infection in man, Japan, 2007. Emerg Infect Dis. 2010;16: 1155-7.

Tajima S, Nerome R, Nukui Y, Kato F, Takasaki T, Kurane I. A single mutation in the Japanese encephalitis virus E protein (S123R) increases its growth rate in mouse neuroblastoma cells and its pathogenicity in mice. Virology. 2010;396: 298-304.

2008年
Harada S, Ishii Y, Yamaguchi K. Extended-spectrum beta-lactamases: implications for the clinical laboratory and therapy. Korean J Lab Med. 2008;28(6):401-12. PMID: 19127103.

Okada H, Kitazawa T, Harada S, Itoyama S, Hatakeyama S, Ota Y, Koike K. Combined treatment with oral kanamycin and parenteral antibiotics for a case of persistent bacteremia and intestinal carriage with Campylobacter coli. Intern Med. 2008;47(14):1363-6. PMID: 18628588.

Ishioka H, Hayakawa K, Shinozaki S, Umezawa M, Hatakeyama S. Group G streptococcal bacteremia and vertebral osteomyelitis in a homosexual man with amebic colitis. Intern Med. 2008;47:317-20.

2007年
Hatakeyama S, Sugaya N, Ito M, Yamazaki M, Ichikawa M, Kimura K, Kiso M, Shimizu H, Kawakami C, Koike K, Mitamura K, Kawaoka Y. Emergence of influenza B viruses with reduced sensitivity to neuraminidase inhibitors. JAMA. 2007;297:1435-42.

Sugaya N, Mitamura K, Yamazaki M, Tamura D, Ichikawa M, Kimura K, Kawakami C, Kiso M, Ito M, Hatakeyama S, Kawaoka Y. Lower clinical effectiveness of oseltamivir against influenza B contrasted with influenza A infection in children. Clin Infect Dis. 2007;44:197-20.

Tajima S, Nukui Y, Takasaki T, Kurane I. Characterization of the variable region in the 3’ non-translated region of dengue type 1 virus. J Gen Virol. 2007;88:2214-22.

Suzuki S, Kitazawa T, Ota Y, Okugawa S, Tsukada K, Nukui Y, Hatakeyama S, Yamaguchi D, Matsuse S, Ishii T, Matsubara T, Yamauchi C, Ota S, Yahagi N, Fukayama M, Koike K. Dengue hemorrhagic shock and disseminated candidiasis. Intern Med. 2007;46:1043-46.

2006年
Imataki O, Makimoto A, Kato S, Bannai T, Numa N, Nukui Y, Morisawa Y, Ishida T, Kami M, Fukuda T, Mori S, Tanosaki R, Takaue Y. Coincidental Outbreak of Methicillin-resistant Staphylococcus Aureus in a Hematopoietic Stem Cell Transplantation Unit. Am J Hematol, 2006;81:664-9

Nukui Y, Tajima S, Kotaki A, Ito M, Takasaki T, Koike K, Kurane I. Novel dengue virus 1 from travelers to Yap State, Micronesia. Emerg Infect Dis 2006;12:343-6.

Tajima S, Nukui Y, Ito M, Takasaki T, Kurane I .Nineteen nucleotides in the variable region of 3' non-translated region are dispensable for the replication of dengue type 1 virus in vitro. Virus Res. 2006;116:38-44.

2005年
Hatakeyama S, Sakai-Tagawa Y, Kiso M, Goto H, Kawakami C, Mitamura K, Sugaya N, Suzuki Y, Kawaoka Y. Enhanced expression of an alpha2,6-linked sialic acid on MDCK cells improves isolation of human influenza viruses and evaluation of their sensitivity to a neuraminidase inhibitor. J Clin Microbiol. 2005;43:4139-46.

Hatakeyama S, Moriya K, Saijo M, Morisawa Y, Kurane I, Koike K, Kimura S, Morikawa S. Persisting humoral antiviral immunity within the Japanese population after the discontinuation in 1976 of routine smallpox vaccinations. Clin Diagn Lab Immunol. 2005;12:520-4. (currently Clinical and Vaccine Immunology)

2004年
Hatakeyama S, Moriya K, Itoyama S, Nukui Y, Uchida M, Shintani Y, Morisawa Y, Kimura S Prevalence of measles, rubella, mumps, and varicella antibodies among healthcare workers in Japan. Infect Control Hosp Epidemiol. 2004;25:591-4.

2021年7月6日更新