ウイルス感染症グループ（113研究室）

研究室紹介

第113研究室は、ウイルス肝炎を中心としたウイルス感染症を研究のテーマとしています。
研究室の歴史は古く、ＯＢには日本のウイルス肝炎の歴史を築かれてきた先生方が多数いらっしゃいます。現在教科書に書かれていることの中に、当研究室の業績が数多く含まれているといっても過言ではありません。
現在は、以下のようなテーマを中心に研究が行われています。

I. ウイルス肝炎に関する研究

A.トランスジェニックマウスを用いた研究
　　1.Ｃ型肝炎ウイルスによる肝発癌のメカニズムに関する研究
　　2.Ｂ型肝炎ウイルスによる肝発癌のメカニズムに関する研究
　　3.Ｃ型肝炎ウイルスによる糖質・脂質代謝異常のメカニズムに関する研究
　　4.Ｃ型肝炎ウイルスによる肝病変発症・進展のメカニズムと治療に関する研究
　　5.Ｃ型肝炎ウイルスによる肝外病変の発生とその治療に関する研究
　B.培養細胞を用いた研究
　　1.Ｃ型肝炎ウイルスとミトコンドリア異常に関する研究
　　2.Ｂ型肝炎ウイルスの複製過程と発癌に関する研究
　C.臨床材料を用いた研究
　　1.Ｂ型慢性肝炎の自然経過及び発癌に関与するウイルス因子に関する研究
　　2.Ｂ型肝細胞癌におけるウイルス遺伝子組み込みの意義に関する研究
　　3.非Ｂ非Ｃ型肝細胞癌におけるウイルスの関与に関する研究
　　4.非アルコール性脂肪性肝炎に関する研究
ウイルス肝炎は、ウイルス感染症の持つ様々な側面を理解する上で、最もよいモデル
の一つだと我々は考えています。やる気のある若い先生方と共にさらに研究を進めていきたいと思っています。

II. HIV感染症の病態進展に関する研究

1.HIV感染症に合併するC型肝炎による肝疾患進展のメカニズムに関する研究
2.HIV感染症に合併するC型肝炎に関する薬剤耐性の研究

連絡先

堤　武也
takeyatsutsumi(アットマーク)g.ecc.u-toykyo.ac.jp

最近の主な業績（2015年ー抜粋）

1. Saito R, Koyano S, Dorin M, Higurashi Y, Misawa Y, Nagano N, Kaneko T, Moriya K. Evaluation of a simple phenotypic method for the detection of carbapenemase-producing Enterobacteriaceae. J Microbiol Methods. 108:45-48, 2015.
2. Koyano S, Tatsuno K, Okazaki M, Ohkusu K, Sasaki T, Saito R, Okugawa S, Moriya K. A Case of Liver Abscess with Desulfovibrio desulfuricans Bacteremia. Case Rep Infect Dis. 2015:354168, 2015.
3. Ogishi M, Yotsuyanagi H, Tsutsumi T, Gatanaga H, Ode H, Sugiura W, Moriya K, Oka S, Kimura S, Koike K. Deconvoluting the composition of low-frequency hepatitis C viral quasispecies: comparison of genotypes and NS3 resistance-associated variants between HCV/HIV coinfected hemophiliacs and HCV monoinfected patients in Japan. PLoS One. 10:e0119145, 2015
4. Ito S, Hirabayashi K, Moriishi K, Matsui Y, Moriya K, Koike K, Matsuura Y, Shiota K, Yagi S. Novel sex-dependent differentially methylated regions are demethylated in adult male mouse livers. Biochem Biophys Res Commun. 462:332-338, 2015.
5. Minami T, Tateishi R, Kondo M, Nakagomi R, Fujiwara N, Sato M, Uchino K, Enooku K, Nakagawa H, Asaoka Y, Kondo Y, Moriya K, Shiina S, Koike K. Serum alpha-fetoprotein has high specificity for the early detection of hepatocellular carcinoma after hepatitis C virus eradication in patients. Medicine (Baltimore). 94:e901, 2015.
6. Uchino K, Tateishi R, Fujiwara N, Minami T, Sato M, Enooku K, Nakagawa H, Asaoka Y, Kondo Y, Yoshida H, Moriya K, Shiina S, Omata M, Koike K. Impact of serum ferritin level on hepatocarcinogenesis in chronic hepatitis C patients. Hepatol Res. doi: 10, 2015.
7. Okushin K, Takahashi Y, Yamamichi N, Shimamoto T, Enooku K, Fujinaga H, Tsutsumi T, Shintani Y, Sakaguchi Y, Ono S, Kodashima S, Fujishiro M, Moriya K, Yotsuyanagi H, Mitsushima T, Koike K. Helicobacter pylori infection is not associated with fatty liver disease including non-alcoholic fatty liver disease: a large-scale cross-sectional study in Japan. BMC Gastroenterol. 15:25, 2015.
8. Kato I, Fujimoto F, Higurashi Y, Yamaguchi R, Takayama K, Suzuki M, Okugawa S, Okazaki M, Moriya K. Antibiotic Susceptibilities of Pseudomonas aeruginosa isolated from blood samples and antibiotic utilization in a university hospital in Japan. Infect Dis Ther. 4:213-218, 2015.
9. Ikeda M, Yagihara Y, Tatsuno K, Okazaki M, Okugawa S, Moriya K.
Clinical characteristics and antimicrobial susceptibility of Bacillus cereus blood stream infections. Ann Clin Microbiol Antimicrob. 15;14:43 .2015
10. Okushin K, Tsutsumi T, Enooku K, Fujinaga H, Kado A, Shibahara J, Fukayama M, Moriya K, Yotsuyanagi H, Koike K. The intrahepatic expression levels of bile acid transporters are inversely correlated with the histological progression of nonalcoholic fatty liver disease. J Gastroenterol. 2015 Nov 25.
11. Ishii K, Tabuchi F, Matsuo M, Tatsuno K, Sato T, Okazaki M, Hamamoto H, Matsumoto Y, Kaito C, Aoyagi T, Hiramatsu K, Kaku M, Moriya K, Sekimizu K. Phenotypic and genomic comparisons of highly vancomycin-resistant Staphylococcus aureus strains developed from multiple clinical MRSA strains by in vitro mutagenesis. Sci Rep. 2015 Nov 25;5:17092
12. Wada K, Yoshikawa T, Yoshikawa JJ, Mitsuda T, Kidouchi K, Kurosu H, Morisawa Y, Aminaka M, Okubo T, Kimura S, Moriya K. Sharp injuries in Japanese operating theaters of HIV/AIDS referral hospitals 2009-2011. Ind Health. 2015 Dec 1.
13. Wakabayashi Y, Okugawa S, Tatsuno K, Ikeda M, Misawa Y, Koyano S, Tsuji E, Yanagimoto S, Hatakeyama S, Moriya K, Yotsuyanagi H. Scedosporium prolificans Endocarditis: Case Report and Literature Review. Intern Med. 2016;55(1):79-82
14. Kishii K, Kikuchi K, Tomida J, Kawamura Y, Yoshida A, Okuzumi K, Moriya K. The first cases of human bacteremia caused by Acinetobacter seifertii in Japan. J Infect Chemother. 2016 Jan 14
15. Aizawa S, Okamoto T, Sugiyama Y, Kouwaki T, Ito A, Suzuki T, Ono C, Fukuhara T, Yamamoto M, Okochi M, Hiraga N, Imamura M, Chayama K, Suzuki R, Shoji I, Moriishi K, Moriya K, Koike K, Matsuura Y. TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis. Nat Commun. 2016 May 4;7:11379.
16. Yuhashi K, Yagihara Y, Misawa Y, Sato T, Saito R, Okugawa S, Moriya K.
Diagnosing Clostridium difficile-associated diarrhea using enzyme immunoassay: the clinical significance of toxin negativity in glutamate dehydrogenase-positive patients. Infect Drug Resist. 2016 May 27;9:93-9.
17. Tian Y, Yang Y, Zhang X, Nakajima T, Tanaka N, Sugiyama E, Kamijo Y, Lu Y, Moriya K, Koike K, Gonzalez FJ, Aoyama T. Age-dependent PPARα activation induces hepatic sulfatide accumulation in transgenic mice carrying the hepatitis C virus core gene. Glycoconj J. 2016 Jun 18
18. Nishikawa H, Shiraki M, Hiramatsu A, Moriya K, Hino K, Nishiguchi S.JSH guidelines for sarcopenia in liver disease (first edition): Recommendation from the working group for creation of sarcopenia assessment criteria in the JSH. Hepatol Res. 2016 Aug 2.
19. Igawa G, Casey M, Sawabe E, Nukui Y, Okugawa S, Moriya K, Koike R, Tohda S, Saito R. Comparison of agar dilution and broth microdilution methods for Clostridium difficile antimicrobial susceptibility testing.
J Glob Antimicrob Resist. 2016 Aug 26;7:43-45
20. Ogishi M, Yotsuyanagi H, Moriya K, Koike K.Delineation of autoantibody repertoire through differential proteogenomics in hepatitis C virus-induced cryoglobulinemia.Sci Rep. 2016 Jul 12;6:29532
21. Tsutsumi T, Okushin K, Enooku K, Fujinaga H, Moriya K, Yotsuyanagi H, Aizaki H, Suzuki T, Matsuura Y, Koike K.Nonstructural 5A Protein of Hepatitis C Virus Interferes with Toll-Like Receptor Signaling and Suppresses the Interferon Response in Mouse Liver.PLoS One. 2017 Jan 20;12(1):
22. Kanno Y, Wakabayashi Y, Ikeda M, Tatsuno K, Misawa Y, Sato T, Yanagimoto S, Okugawa S, Moriya K, Yotsuyanagi H. Catheter-related bloodstream infection caused by Kodamaea ohmeri: A case report and literature review.J Infect Chemother. 2017 Feb 7.
23. Tabuchi F, Matsumoto Y, Ishii M, Tatsuno K, Okazaki M, Sato T, Moriya K, Sekimizu K. Synergistic effects of vancomycin and β-lactams against vancomycin highly resistant Staphylococcus aureus.J Antibiot (Tokyo). 2017
24. Kamei J, Yagihara Y, Kume H, Horiuchi T, Sato T, Nakagawa T, Fujimura T, Fukuhara H, Moriya K, Homma Y. Prevalence and characteristics of fecal antimicrobial-resistant Escherichia coli in a cohort of Japanese men undergoing prostate biopsy.Int J Urol. 2017 Feb
25. Hatakeyama S, Ohama Y, Okazaki M, Nukui Y, Moriya K. Antimicrobial susceptibility testing of rapidly growing mycobacteria isolated in Japan.BMC Infect Dis. 2017
26. Norie Yamada,Ryuichi Sugiyama,Sayuri Nitta,Asako Murayama,Mioru Kobayashi,Chiaki Okuse,Michihiro Suzuki,Kiyomi Yasuda,Hiroshi Yotsuyanagi,Kyoji Moriya,Koike Kazuhiko,Takaji Wakita,Takanobu Kato.Resisitance mutations of Hepatitis B virus in entecavir –Refractory patients.Hepatology Communications.2017 110-121
27. Ikeda M, Kobayashi T, Suzuki T, Wakabayashi Y, Ohama Y, Maekawa S, Takahashi S, Homma Y, Tatsuno K, Sato T, Okugawa S, Moriya K, Yotsuyanagi H. Propionimicrobium lymphophilum and Actinotignum schaalii bacteraemia: a case report. New Microbes New Infect. 2017 Apr 4;18:18-21
28. Matsuda K, Koya J, Toyama K, Ikeda M, Arai S, Nakamura F, Okugawa S, Moriya K, Kurokawa M. A therapeutic benefit of daptomycin against glycopeptide-resistant gram-positive cocci bloodstream infections under neutropenia. J Infect Chemother. 2017
29. Tabuchi F, Matsumoto Y, Ishii M, Tatsuno K, Okazaki M, Sato T, Moriya K, Sekimizu K. D-cycloserine increases the effectiveness of vancomycin against vancomycin-highly resistant Staphylococcus aureus. J Antibiot (Tokyo). 2017 Jul;70(8):907-910. doi:
30. Keiichi Jimbo,Kazuhiko Mori, Susumu Aikou, Mitsuhiro Okazaki, Tomoaki Sato, Kyoji Moriya, Yoko Kawase-Koga, Yoshiyuki Mori, Yuki Kanno, Yukinori Yamagata, Koichi Yagi, Masato Nishida, Hiroharu Yamashita, Sachiyo Nomura, Yasuyuki Seto. Detection and identification of pathogenic bacteria responsible for postoperative pneumonia after esophagectomy.Esophagus.153-158,2017.
31. Yoshikuni Kawaguchi,Yoshihiro Sakamoto,Daisuke Ito,Junichi Arita,Nobuhisa Akamatsu,Junichi Kaneko,Kiyoshi Hasegawa,Kyoji Moriya,Norihiro Kokudo.Statin use is assicated with a reduced risk of hepatocellular carcinoma recurrence after initial lver resection.Bioscience Trends.e-pub.2017,Oct29
32.Yamamoto S, Ikeda M, Fujimoto F, Okamoto K, Wakabayashi Y, Sato T, Tatsuno K, Kaburaki T, Yoshida S, Okugawa S, Koike K, Moriya K. Bilateral Candida endophthalmitis accompanying Candida lusitaniae bloodstream infection: A case report. J Infect Chemother. 2017 Oct 25.
33. Hirano J, Okamoto T, Sugiyama Y, Suzuki T, Kusakabe S, Tokunaga M, Fukuhara T, Sasai M, Tougan T, Matsunaga Y, Yamashita K, Sakai Y, Yamamoto M, Horii. Characterization of SPP inhibitors suppressing propagation of HCV and protozoa. Proc Natl Acad Sci U S A. 2017 Nov 29.
34. T. Chino, Y. Nukui, Y. Morishita　 and K. Moriya.Morphological bactericidal fast-acting　effects of peracetic acid, a high-level　disinfectant, against Staphylococcus aureus　and Pseudomonas aeruginosa biofilms in　tubing. Antimicrobial Resistance and Infection Control (2017) 6:122
35. Araoka H, Baba M, Okada C, Kimura M, Sato T, Yatomi Y, Moriya K, Yoneyama A. First evidence of bacterial translocation from the intestinal tract as a route of Helicobacter cinaedi bacteremia. Helicobacter. 2017 Dec 8.
36. Matsuda K, Koya J, Toyama K, Ikeda M, Arai S, Nakamura F, Okugawa S, Moriya K, Kurokawa M. A therapeutic benefit of daptomycin against glycopeptide-resistant gram-positive cocci bloodstream infections under neutropenia. J Infect Chemother. 2017 Nov;23(11):788-790.
37. Aoki K, Harada S, Yahara K, Ishii Y ,Motooka D, Nakamura S, Akeda Y, Iida T, Tomono K, Iwata S, Moriya K, Tateda K. Molecular characterization of IMP-1-producing Enterobacter cloacae complex isolates in Tokyo. Antimicrob Agents Chemother. 2018 Jan 8