名古屋大学 医学部保健学科理学療法学専攻・医学系研究科リハビリテーション療法学 亀高研究室

研究業績

2019~2023年

Downregulation of PGRMC1 accelerates differentiation and fusion of a human trophoblast cell line. Tsuru A, Yoshie M, Suzuki M, Mochizuki H, Kametaka S, Ohmaru-Nakanishi T, Azumi M, Kusama K, Kato K, Tamura K. J Endocrinol. 2023 Nov 1:JOE-23-0163. doi: 10.1530/JOE-23-0163. Online ahead of print.

Protective effects of hachimijiogan (HJG), a Japanese Kampo medicine, on cancer cachectic muscle wasting in mice. Kametaka S, Isobe M, Komata K, Morinaga M, Nagahata K, Lee-Hotta S, Uchiyama Y, Shibata M, Sugiura H. Biomed Res. 2023;44(5):199-207. doi: 10.2220/biomedres.44.199.

Novel cell-based system to assay cell-cell fusion during myotube formation. Isobe M, Suzuki Y, Sugiura H, Shibata M, Ohsaki Y, Kametaka S. Biomed Res. 2022;43(4):107-114. doi: 10.2220/biomedres.43.107.

Radiosensitization Effect of Gold Nanoparticles on Plasmid DNA Damage Induced by Therapeutic MV X-rays. Yogo K, Misawa M, Shimizu H, Kitagawa T, Hirayama R, Ishiyama H, Yasuda H, Kametaka S, Takami S. Nanomaterials (Basel). 2022 Feb 25;12(5):771. doi: 10.3390/nano12050771.

Aerobic Exercise Ameliorates Cancer Cachexia-Induced Muscle Wasting through Adiponectin Signaling. Morinaga M, Sako N, Isobe M, Lee-Hotta S, Sugiura H, Kametaka S. Int J Mol Sci. 2021 Mar 18;22(6):3110. doi: 10.3390/ijms22063110.

The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal. Hieda M, Matsumoto T, Isobe M, Kurono S, Yuka K, Kametaka S, Wang JY, Chi YH, Kameda K, Kimura H, Matsuura N, Matsuura S. Sci Rep. 2021 Mar 8;11(1):5358. doi: 10.1038/s41598-021-84750-4.

Median nerve injury does not contribute to early onset of decreased grip strength due to repetitive reaching and grasping tasks in rats. Fujiwara M, Yoshito N, Iwata M, Lee-Hotta S, Inoue T, Aizawa Y, Kametaka S, Asai Y, Suzuki S. Neuro Endocrinol Lett. 2020 Sep;41(2):76-85.

Author Correction: GGA2 interacts with EGFR cytoplasmic domain to stabilize the receptor expression and promote cell growth. Uemura T, Kametaka S, Waguri S. Sci Rep. 2020 May 1;10(1):7675. doi: 10.1038/s41598-020-64604-1.

Role of the BDNF-TrkB pathway in KCC2 regulation and rehabilitation following neuronal injury: A mini review. Lee-Hotta S, Uchiyama Y, Kametaka S. Neurochem Int. 2019 Sep;128:32-38. doi: 10.1016/j.neuint.2019.04.003. Epub 2019 Apr 12.

2008~2018年

Correction: Clathrin adaptor GGA1 modulates myogenesis of C2C12 myoblasts. Isobe M, Lee S, Waguri S, Kametaka S. PLoS One. 2018 Dec 13;13(12):e0209441. doi: 10.1371/journal.pone.0209441. eCollection 2018.

Clathrin adaptor GGA1 modulates myogenesis of C2C12 myoblasts. Isobe M, Lee S, Waguri S, Kametaka S. PLoS One. 2018 Nov 15;13(11):e0207533. doi: 10.1371/journal.pone.0207533. eCollection 2018.

Intracellular localization of GGA accessory protein p56 in cell lines and central nervous system neurons. Uemura T, Sawada N, Sakaba T, Kametaka S, Yamamoto M, Waguri S. Biomedical Research 2018;39(4):179-187. doi: 10.2220/biomedres.39.179.

GGA2 interacts with EGFR cytoplasmic domain to stabilize the receptor expression and promote cell growth. Uemura T, Kametaka S, Waguri S. Sci Rep. 2018 Jan 22;8(1):1368. doi: 10.1038/s41598-018-19542-4.

Proteasome dysfunction activates autophagy and the Keap1-Nrf2 pathway. Kageyama S, Sou YS, Uemura T, Kametaka S, Saito T, Ishimura R, Kouno T, Bedford L, Mayer RJ, Lee MS, Yamamoto M, Waguri S, Tanaka K, Komatsu M. J Biol Chem. 2014 Sep 5;289(36):24944-55. Epub 2014 Jul 21.

A cluster of thin tubular structures mediates transformation of the endoplasmic reticulum to autophagic isolation membrane. Uemura T, Yamamoto M, Kametaka A, Sou YS, Yabashi A, Yamada A, Annoh H, Kametaka S, Komatsu M, Waguri S. Mol Cell Biol. 2014 May;34(9):1695-706. Epub 2014 Mar 3.

ArfGAP3 regulates the transport of cation-independent mannose 6-phosphate receptor in the post-Golgi compartment. Shiba Y, Kametaka S, Waguri S, Presley JF, Randazzo PA. Curr Biol. 2013 Oct 7;23(19):1945-51. Epub 2013 Sep 26.

AP-1 clathrin adaptor and CG8538/Aftiphilin are involved in Notch signaling during eye development in Drosophila melanogaster. Kametaka S, Kametaka A, Yonekura S, Haruta M, Takenoshita S, Goto S, Waguri S. J Cell Sci. 2012 Feb 1;125(Pt 3):634-48.

Visualization of TGN-endosome trafficking in mammalian and Drosophila cells. Kametaka S, Waguri S. Methods Enzymol. 2012;504:255-71. Review.

Functional characterization of protein-sorting machineries at the trans-Golgi network in Drosophila melanogaster. Kametaka S, Sawada N, Bonifacino JS, Waguri S. J Cell Sci. 2010 Feb 1;123(Pt 3):460-71. Epub 2010 Jan 12.

[Regulatory mechanisms of the clathrin adaptor molecules AP-1 and GGAs]. Kametaka S, Bonifacino JS. Tanpakushitsu Kakusan Koso(蛋白質核酸酵素). 2008 Dec;53(16 Suppl):2046-52. Review.

1996~2007年

Specific depletion of GGA2 causes cathepsin D missorting in HeLa cells. Hida T, Ikeda H, Kametaka S, Akazawa C, Kohsaka S, Ebisu S, Uchiyama Y, Waguri S. Arch Histol Cytol. 2007 Dec;70(5):303-12.

Canonical interaction of cyclin G associated kinase with adaptor protein 1 regulates lysosomal enzyme sorting. Kametaka S, Moriyama K, Burgos PV, Eisenberg E, Greene LE, Mattera R, Bonifacino JS. Mol Biol Cell. 2007 Aug;18(8):2991-3001. Epub 2007 May 30.

Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors. Rojas R, Kametaka S, Haft CR, Bonifacino JS. Mol Cell Biol. 2007 Feb;27(3):1112-24. Epub 2006 Nov 13.

Beta-site APP cleaving enzyme 1 (BACE1) is increased in remaining neurons in Alzheimer's disease brains. Harada H, Tamaoka A, Ishii K, Shoji S, Kametaka S, Kametani F, Saito Y, Murayama S. Neurosci Res. 2006 Jan;54(1):24-9. Epub 2005 Nov 11.

Epidermal growth factor-dependent phosphorylation of the GGA3 adaptor protein regulates its recruitment to membranes. Kametaka S, Mattera R, Bonifacino JS. Mol Cell Biol. 2005 Sep;25(18):7988-8000.

Early-phase redistribution of the cation-independent mannose 6-phosphate receptor by U18666A treatment in HeLa cells. Tomiyama Y, Waguri S, Kanamori S, Kametaka S, Wakasugi M, Shibata M, Ebisu S, Uchiyama Y. Cell Tissue Res. 2004 Sep;317(3):253-64. Epub 2004 Jul 31.

Insights into the phosphoregulation of beta-secretase sorting signal by the VHS domain of GGA1. Shiba T, Kametaka S, Kawasaki M, Shibata M, Waguri S, Uchiyama Y, Wakatsuki S. Traffic. 2004 Jun;5(6):437-48.

Purification, cDNA cloning, and secretory properties of FLRG protein from PC12 cells and the distribution of FLRG mRNA and protein in rat tissues. Ohsawa Y, Zhang G, Kametaka S, Shibata M, Koike M, Waguri S, Uchiyama Y. Arch Histol Cytol. 2003 Oct;66(4):367-81.

Predominant expression of the short form of GGA3 in human cell lines and tissues. Wakasugi M, Waguri S, Kametaka S, Tomiyama Y, Kanamori S, Shiba Y, Nakayama K, Uchiyama Y. Biochem Biophys Res Commun. 2003 Jul 4;306(3):687-92.

Involvement of two different cell death pathways in retinal atrophy of cathepsin D-deficient mice. Koike M, Shibata M, Ohsawa Y, Nakanishi H, Koga T, Kametaka S, Waguri S, Momoi T, Kominami E, Peters C, Figura Kv, Saftig P, Uchiyama Y. Mol Cell Neurosci. 2003 Feb;22(2):146-61.

Identification of phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE)). Kametaka S, Shibata M, Moroe K, Kanamori S, Ohsawa Y, Waguri S, Sims PJ, Emoto K, Umeda M, Uchiyama Y. J Biol Chem. 2003 Apr 25;278(17):15239-45. Epub 2003 Feb 13.

The expression of tripeptidyl peptidase I in various tissues of rats and mice. Koike M, Shibata M, Ohsawa Y, Kametaka S, Waguri S, Kominami E, Uchiyama Y. Arch Histol Cytol. 2002 Aug;65(3):219-32.

An ultrastructural and immunohistochemical study of PC12 cells during apoptosis induced by serum deprivation with special reference to autophagy and lysosomal cathepsins. Ohsawa Y, Isahara K, Kanamori S, Shibata M, Kametaka S, Gotow T, Watanabe T, Kominami E, Uchiyama Y. Arch Histol Cytol. 1998 Dec;61(5):395-403.

Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons. Koike M, Nakanishi H, Saftig P, Ezaki J, Isahara K, Ohsawa Y, Schulz-Schaeffer W, Watanabe T, Waguri S, Kametaka S, Shibata M, Yamamoto K, Kominami E, Peters C, von Figura K, Uchiyama Y. J Neurosci. 2000 Sep 15;20(18):6898-906.

Overexpression of cation-dependent mannose 6-phosphate receptor prevents cell death induced by serum deprivation in PC12 cells. Kanamori S, Waguri S, Shibata M, Isahara K, Ohsawa Y, Konishi A,Kametaka S, Watanabe T, Ebisu S, Kominami E, Uchiyama Y. Biochem Biophys Res Commun. 1998 Oct 9;251(1):204-8.

Participation of cathepsins B and D in apoptosis of PC12 cells following serum deprivation. Shibata M, Kanamori S, Isahara K, Ohsawa Y, Konishi A, Kametaka S, Watanabe T, Ebisu S, Ishido K, Kominami E, Uchiyama Y. Biochem Biophys Res Commun. 1998 Oct 9;251(1):199-203.

Apg14p and Apg6/Vps30p form a protein complex essential for autophagy in the yeast, Saccharomyces cerevisiae. Kametaka S, Okano T, Ohsumi M, Ohsumi Y. J Biol Chem. 1998 Aug 28;273(35):22284-91.

Structural and functional analyses of APG5, a gene involved in autophagy in yeast. Kametaka S, Matsuura A, Wada Y, Ohsumi Y. Gene. 1996 Oct 31;178(1-2):139-43.

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