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(*equal contribution)


  1. Hasegawa R., Ebina T., Tanaka Y.R., Kobayashi K., and Matsuzaki M.
    Structural dynamics and stability of corticocortical and thalamocortical axon terminals during motor learning.
    PLoS One 15, e0234930, 2020.
  2. Matsuzaki M. and Ebina T.
    Common marmoset as a model primate for study of the motor control system.
    Current Opinion in Neurobiology 64, 103-110, 2020.
  3. Kato D., Wake H., Lee P.R., Tachibana Y., Ono R., Sugio S., Tsuji Y., Tanaka Y.H., Tanaka Y.R., Masamizu Y., Hira R., Moorehouse A.J., Tamamaki N., Ikenaka K., Matsukawa N., Fields R.D., Nabekura J., and Matsuzaki M.
    Motor learning requires myelination to reduce asynchrony and spontaneity in neural activity.
    Glia 68, 193-210, 2020.
  4. Ebina T., Obara K., Watakabe A., Masamizu Y., Terada S., Matoba R., Takaji M., Hatanaka N., Nambu A., Mizukami H., Yamamori T., and Matsuzaki M.
    Arm movements induced by noninvasive optogenetic stimulation of the motor cortex in the common marmoset.
    Proceedings of the National Academy of Sciences of the United States of America 116, 22844-22850, 2019.
  5. Tsutsumi S., Hidaka N., Isomura Y., Matsuzaki M., Sakimura K., Kano M., and Kitamura K.
    Modular organization of cerebellar climbing fiber inputs during goal-directed behavior.
    eLife 8, e47021, 2019.
  6. Terada S., Kobayashi K., Ohkura M., Nakai J., and Matsuzaki M.
    Super-wide-field two-photon imaging with a micro-optical device moving in post-objective space.
    Nature Communications 9, 3550, 2018.
  7. *Tanaka Y.H., *Tanaka Y.R., Kondo M., Terada S., Kawaguchi Y., and Matsuzaki M.
    Thalamocortical axonal activity in motor cortex exhibits layer-specific dynamics during motor learning.
    Neuron 100, 244-258, 2018.
  8. *Yoshida E., *Terada S., Tanaka Y.H., Kobayashi K., Ohkura M., Nakai J., and Matsuzaki M.
    Wide-field calcium imaging of mouse thalamocortical synapses with an 8 K ultra-high-definition camera.
    Scientific Reports 8, 8324, 2018.
  9. *Ebina, T., *Masamizu Y., Tanaka Y.R., Watakabe A., Hirakawa R., Hirayama Y., Hira R., Terada S., Koketsu D., Hikosaka K., Mizukami H., Nambu A., Sasaki E., Yamamori T., and Matsuzaki M.
    Two-photon imaging of neuronal activity in motor cortex of marmosets during upper-limb movement tasks.
    Nature Communications 9, 1879, 2018.
  10. Endo K., Ishigaki S., Masamizu Y., Fujioka Y., Watakabe A., Yamamori T., Hatanaka N., Nambu A., Okado H., Katsuno M., Watanabe H., Matsuzaki M., and Sobue G.
    Silencing of FUS in the common marmoset (Callithrix jacchus) brain via stereotaxic injection of an adeno-associated virus encoding shRNA.
    Neuroscience Research 130, 56-64, 2018.


  1. Kondo M., Kobayashi K., Ohkura M., Nakai J., and Matsuzaki M.
    Two-photon calcium imaging of the medial prefrontal cortex and hippocampus without cortical invasion.
    eLife 6, e26839, 2017.
    Vogt N. (2017). Imaging deep in the cortex and beyond. Nature Methods 14, 1131.
  2. *Terada S., *Matsubara D., *Onodera K., Matsuzaki M., Uemura T., and Usui T.
    Neuronal processing of noxious thermal stimuli mediated by dendritic Ca2+influx in Drosophila sensory neurons.
    eLife 5, e12959, 2016.
  3. *Sadakane O., *Masamizu Y., *Watakabe A., *Terada S., Ohtsuka M., Takaji M., Mizukami H., Ozawa K., Kawasaki H., Matsuzaki M., and Yamamori T.
    Long-term two-photon calcium imaging of neuronal populations with subcellular resolution in adult non-human primates.
    Celll Reports 13, 1989-1999, 2015.
  4. Hira R., Terada S., Kondo M., and Matsuzaki M.
    Distinct functional modules for discrete and rhythmic forelimb movements in the mouse motor cortex.
    Journal of Neuroscience 35, 13311-13322, 2015.
  5. Hira R., Ohkubo F., Masamizu Y., Ohkura M., Nakai J., Okada T., and Matsuzaki M.
    Reward-timing-dependent bidirectional modulation of cortical microcircuits during
    optical single-neuron operant conditioning.
    Nature Communications 5, 5551, 2014.
  6. *Masamizu Y., *Tanaka Y.R., Tanaka Y.H., Hira R., Ohkubo F., Kitamura K., Isomura Y., Okada T., and Matsuzaki M.
    Two distinct layer-specific dynamics of cortical ensembles during learning of a motor task.
    Nature Neuroscience 17, 987-994, 2014.


  1. Asrican B., Augustine G.J., Berglund K., Chen S.,  Chow N., Deisseroth K., Feng G., Gloss B., Hira R., Hoffmann C., Kasai H., Katarya M., Kim J., Kudolo J., Lee L., Lo S., Mancuso J., Matsuzaki M., Nakajima R., Qui L., Tan G., Tang Y., Ting J.T., Tsuda S., Wen L., Zhang X, and Zhao S.
    Next-generation transgenic mice for optogenetic analysis of neural circuits.
    Frontiers in Neural Circuits 7, 160, 2013.
  2. *Hayama T., *Noguchi J., Watanabe S., Takahashi N., Hayashi-Takagi A., Ellis-Davies G.C.R., Matsuzaki M., and Kasai H.
    GABA promotes the competitive selection of dendritic spines by controlling local Ca2+ signaling.
    Nature Neuroscience 16, 1409-1416, 2013.
  3. *Hira R., *Ohkubo F., Tanaka Y.R., Masamizu Y., Augustine G.J., Kasai H., and
    Matsuzaki M.
    In vivo optogenetic tracing of functional corticocortical connections
    between motor forelimb areas.
    Frontiers in Neural Circuits 7, 55, 2013.
  4. Hira R., Ohkubo F., Ozawa K., Isomura Y., Kitamura K., Kano M., Kasai H., and Matsuzaki M.
    Spatiotemporal dynamics of functional clusters of neurons in the mouse motor cortex during a voluntary movement.
    Journal of Neuroscience 33, 1377-1390, 2013.
  5. Kimura R., Saiki A., Fujiwara-Tsukamoto Y., Ohkubo F., Kitamura K.,
    Matsuzaki M., Sakai Y. and Isomura Y.
    Reinforcing operandum: rapid and reliable learning of skilled forelimb
    movements by head-fixed rodents.
    Journal of Neurophysiology 108, 1781-92, 2012.
  6. Ako R., Wakimoto M., Ebisu H., Tanno K., Hira R., Kasai H., Matsuzaki M. and Kawasaki H.
    Simultaneous visualization of multiple neuronal properties with single-cell resolution in the living rodent brain.
    Molecular and Cellular Neuroscience 48, 246-257, 2011. 
  7. Kanemoto Y., Matsuzaki M., Morita S., Hayama T., Noguchi J., Senda N., Momotake A., Arai T., and Kasai H.
    Spatial distributions of GABA receptors and local inhibition of Ca2+ transients studied with GABA uncaging in the dendrites of CA1 pyramidal neurons.
    PLoS One 6. e22652, 2011.
  8. Matsuzaki M. and Kasai H.
    Two-Photon Uncaging Microscopy.
    Cold Spring Harbor Protocols, pdb.prot5620, 2011.
  9. Noguchi J., Nagaoka A., Watanabe S., Ellis-Davies G.C.R., Kitamura K., Kano M., Matsuzaki M. and Kasai H.
    In vivo two-photon uncaging of glutamate revealing the structure-function relationships of dendritic spines in the neocortex of adult mice.
    Journal of Physiology 589, 2447-2457, 2011.
  10. Matsuzaki M., Ellis-Davies G.C.R., Kanemoto Y. and Kasai H.
    Simultaneous two-photon activation of presynaptic cells and calcium imaging in postsynaptic dendritic spines.
    Neural Systems & Circuits 1. 2, 2011.
  11. Matsuzaki M., Hayama T., Kasai H. and Ellis-Davies G.C.R.
    Two-photon uncaging of γ-aminobutyric acid in intact brain tissue.
    Nature Chemical Biology 6, 255-257, 2010.
  12. Obi N., Momotake A., Kanemoto Y., Matsuzaki M., Kasai H. and Arai T.
    1-Acyl-5-methoxy-8-nitro-1,2-dihydroquinoline: A biologically useful photolabile precursor of carboxylic acids.
    Tetrahedron letters 51. 1642-1647, 2010.
  13. *Kantevari S., *Matsuzaki M., Kanemoto Y., Kasai H. and Ellis-Davies G.C.R.
    Two-color, two-photon uncaging of glutamate and GABA.
    Nature Methods 7. 123-125, 2010.


  1. Hira R., Honkura N., Noguchi J., Maruyama Y., Augustine G.J., Kasai H. and Matsuzaki M.
    Transcranial optogenetic stimulation for functional mapping of the motor cortex.
    Journal of Neuroscience Methods 179. 258-263, 2009.
  2. Yasumatsu N., Matsuzaki M., Miyazaki T., Noguchi J. and Kasai H.
    Principles of long-term dynamics of dendritic spines.
    Journal of Neuroscience 28. 13592-13608, 2008.
  3. Honkura N., Matsuzaki M., Noguchi J., Ellis-Davies G.C.R. and Kasai H.
    The subspine organization of actin fibers regulates the structure and plasticity of dendritic spines.
    Neuron 57. 719-729, 2008.
  4. Tanaka J., Horiike Y., Matsuzaki M., Miyazaki T., Ellis-Davies G.C.R. and Kasai H.
    Protein-synthesis and neurotrophin dependent structural plasticity of single dendritic spines.
    Science 319. 1683-1687, 2008.
  5. Matsuzaki M., Ellis-Davies G.C.R. and Kasai H.
    High-resolution mapping of synaptic connections by two-photon macro photolysis of caged glutamate.
    Journal of Neurophysiology 99. 1535-1544, 2008.
  6. Ellis-Davies G..C.R., Matsuzaki M., Paukert M., Kasai H. and Bergles D.E.
    4-carboxymethoxy-5,7-dinitroindolinyl-glu: an improved caged glutamate for expeditious ultraviolet and 2-photon photolysis in brain slices.
    Journal of Neuroscience 27. 6601-6604, 2007.
  7. *Wang H., *Peca J., *Matsuzaki M., Matsuzaki K., Noguchi J., Qiu L., Wang D., Zhang F., Boyden E., Deisseroth K., Kasai H., Hall W.C., Feng G., and Augustine G.J.
    High-speed mapping of synaptic connectivity using photostimulation in Channelrhodopsin-2 transgenic mice.
    Proceedings of the National Academy of Sciences of the United States of America. 104. 8143-8148, 2007.
  8. Matsuzaki M.
    Factors critical for the plasticity of dendritic spines and memory storage.
    Neuroscience Research 57. 1-9, 2007.
  9. Ohkura M., Matsuzaki M., Kasai H., Imoto K. and Nakai J.
    Genetically encoded bright Ca2+ probe applicable for dynamic Ca2+ imaging of dendritic spines.
    Analytical Chemistry 77. 5861-5869, 2005.
  10. Noguchi J., Matsuzaki M., Ellis-Davies G.C.R. and Kasai H.
    Spine-neck geometry determines NMDA-receptor dependent Ca2+ signaling in dendrites.
    Neuron 46. 609-622, 2005.
  11. Tanaka J., Matsuzaki M., Tarusawa E., Momiyama A., Molnar E., Kasai H. and Shigemoto R.
    Number and density of AMPA receptors in single synapses in immature cerebellum.
    Journal of Neuroscience 25. 799-807, 2005.


  1. Sakai N., Tsubokawa H., Matsuzaki M., Kajimoto T., Takahashi E., Ren Y., Ohmori S., Shirai Y., Matsubayashi H., Chen J., Duman RS., Kasai H. and Saito N.
    Propagation of γPKC translocation along the dendrites of Purkinje cell in γPKC-GFP transgenic mice.
    Genes to Cells 9. 945-57, 2004.
  2. Matsuzaki M., Honkura N., Ellis-Davies G.C.R. and Kasai H.
    Structural basis of long-term potentiation in single dendritic spines.
    Nature 429. 761-766 2004.
  3. Kasai H., Matsuzaki M., Noguchi J., Yasumatsu N. and Nakahara H.
    Structure-stability-function relationships of dendritic spines.
    Trends in Neurosciences 26. 360-368, 2003.
  4. Matsuzaki M., Ellis-Davies G.C.R., Nemoto T., Miyashita Y., Iino M. and Kasai H.
    Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons.
    Nature Neuroscience 4. 1086-1092, 2001.


  1. Matsuzaki M. and Saigo K.
    hedgehog signaling independent of engrailed and wingless required for post-S1 neuroblast formation in Drosophila CNS.
    Development 122. 3567-3575, 1996.
  2. Higashijima S., Shishido E., Matsuzaki M. and Saigo K.
    eagle, a member of the steroid receptor gene superfamily is expressed in a subset of neuroblasts and regulates the fate of their putative progeny in the Drosophila CNS.
    Development 122. 527-536, 1996.