2017

1. Omagari K, Suruga K, Kyogoku A, Nakamura S, Nakamoto A, Nishioka S, Ichimura M, Miyata Y, Tajima K, Tsuneyama K, Tanaka K. A fermented mixed tea made with camellia (Camellia japonica) and third-crop green tea leaves prevents nonalcoholic steatohepatitis in Sprague-Dawley rats fed a high-fat and high-cholesterol diet. Hepatobiliary Surg Nutr. 2017 in press

2.Fujimoto Y, Tsuneyama K, Kuramoto N, Hayashi S, Yoshida N, Morioka A, Teramoto M, Nakajima H, Takeuchi T, Azuma YT. Exacerbated experimental pancreatitis in interleukin-19 knockout mice. Glob Drugs Therap. 2017 in press.

3. Tsuneyama K, Baba H, Matsumoto M, Kobayashi T, Morimoto Y, Tsunematsu T, Ogawa H. Effectiveness of new animal models for the analysis of metabolic syndrome-associated liver diseases. Patrol Int. 2017 in press

4. Nishijima H, Kajimoto T, Matsuoka Y, Mouri Y, Morimoto J, Matsumoto M, Kawano H, Nishioka Y, Uehara H, Izumi K, Tsuneyama K, Okazaki IM, Okazaki T, Hosomichi K, Shiraki A, Shibutani M, Mitsumori K, Matsumoto M. Paradoxical development of polymyositis-like autoimmunity through augmented expression of autoimmune regulator (AIRE). J Autoimmun. 2017 in press

5. Bae HR, Hodge DL, Yang GX, Leung PSC, Chodisetti SB, Valencia JC, Sanford M, Fenimore JM, Rahman ZSM, Tsuneyama K, Norman GL, Gershwin ME, Young HA. The interplay of type I and type II interferons in murine autoimmune cholangitis as a basis for sex-biased autoimmunity. Hepatology. 2017 in press

6. Baba H, Kurano M, Nishida T, Hatta H, Hokao R, Tsuneyama K. Facilitatory effect of insulin treatment on hepatocellular carcinoma development in diabetes.  BMC Res Notes. 2017 Sep 13;10(1):478.

7. Nawaz A, Aminuddin A, Kado T, Takikawa A, Yamamoto S, Tsuneyama K, Igarashi Y, Ikutani M, Nishida Y, Nagai Y, Takatsu K, Imura J, Sasahara M, Okazaki Y, Ueki K, Okamura T, Tokuyama K, Ando A, Matsumoto M, Mori H, Nakagawa T, Kobayashi N, Saeki K, Usui I, Fujisaka S, Tobe K. CD206(+) M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors. Nat Commun. 2017 Aug 18;8(1):286.

8. Matsumoto K, Ichimura M, Tsuneyama K, Moritoki Y, Tsunashima H, Omagari K, Hara M, Yasuda I, Miyakawa H, Kikuchi K. Fructo-oligosaccharides and intestinal barrier function in a methionine-choline-deficient mouse model of nonalcoholic steatohepatitis. PLoS One. 2017 Jun 20;12(6):e0175406.

9. Takeuchi M, Matsuzaki K, Tsuneyama K, Nishimura M, Takiguchi E, Harada M. Ovarian Large Cell Neuroendocrine Carcinoma Associated with Serous Carcinoma: Correlation of Pathology with MR Imaging. Magn Reson Med Sci. 2017 in press

10. Shimada S, Tajiri K, Baba H, Minemura M, Tsuneyama K, Nakano M, Sugiyama T. Peritumoral Hyperplasia in Hepatic Sclerosed Hemangioma. ACG Case Rep J. 2017 Apr 26;4:e61.

11. Nguyen Canh H, Harada K, Ouchi H, Sato Y, Tsuneyama K, Kage M, Nakano M, Yoshizawa K, Takahashi A, Abe M, Kang JH, Koike K, Inui A, Fujisawa T, Takaki A, Arinaga-Hino T, Torimura T, Suzuki Y, Fujiwara K, Zeniya M, Ohira H, Tanaka A, Takikawa H; Intractable Liver and Biliary Diseases Study Group of Japan. Acute presentation of autoimmune hepatitis: a multicentre study with detailed histological evaluation in a large cohort of patients. J Clin Pathol. 2017 in press

12. Ikutani M, Tsuneyama K, Kawaguchi M, Fukuoka J, Kudo F, Nakae S, Arita M, Nagai Y, Takaki S, Takatsu K. Prolonged activation of IL-5-producing ILC2 causes  pulmonary arterial hypertrophy. JCI Insight. 2017 Apr 6;2(7):e90721.

13. Tsuneyama K, Baba H, Morimoto Y, Tsunematsu T, Ogawa H. Primary Biliary Cholangitis: Its Pathological Characteristics and Immunopathological Mechanisms.  J Med Invest. 2017;64(1.2):7-13.

14. Watanabe S, Takahashi T, Ogawa H, Uehara H, Tsunematsu T, Baba H, Morimoto Y, Tsuneyama K. Daily Coffee Intake Inhibits Pancreatic Beta Cell Damage and Nonalcoholic Steatohepatitis in a Mouse Model of Spontaneous Metabolic Syndrome,  Tsumura-Suzuki Obese Diabetic Mice. Metab Syndr Relat Disord. 2017 May;15(4):170-177.

15. Chang C, Lleo A, Kananurak A, Grizzi F, Tsuneyama K, Invernizzi P, Bevins CL, Bowlus CL. Human β-Defensin 2 in Primary Sclerosing Cholangitis. Clin Transl Gastroenterol. 2017 Mar 16;8(3):e80.

16. Shirai Y, Oda S, Makino S, Tsuneyama K, Yokoi T. Establishment of a mouse model of enalapril-induced liver injury and investigation of the pathogenesis. Lab Invest. 2017 Jul;97(7):833-842.

17. Ma HD, Ma WT, Liu QZ, Zhao ZB, Liu MZ, Tsuneyama K, Gao JM, Ridgway WM, Ansari AA, Gershwin ME, Fei YY, Lian ZX. Chemokine receptor CXCR3 deficiency exacerbates murine autoimmune cholangitis by promoting pathogenic CD8(+) T cell activation. J Autoimmun. 2017 Mar;78:19-28.

18. Ichimura M, Masuzumi M, Kawase M, Sakaki M, Tamaru S, Nagata Y, Tanaka K, Suruga K, Tsuneyama K, Matsuda S, Omagari K. A diet-induced Sprague-Dawley rat model of nonalcoholic steatohepatitis-related cirrhosis. J Nutr Biochem. 2017 Feb;40:62-69.

19. Oda S, Shirai Y, Akai S, Nakajima A, Tsuneyama K, Yokoi T. Toxicological role of an acyl glucuronide metabolite in diclofenac-induced acute liver injuly in mice. J Appl Toxicol. 2017 may;37(5):545-553.

2016

Sasaki E, Iida A, Oda S, Tsuneyama K, Fukami T, Nakajima M, Yokoi T. Pathogenic analysis of carbamazepine-induced liver injury in F344 rats focused on immune-and inflammation-related facters. Exp Toxicol Pathol. 2016 Jan;68(1):27-38.

 

Yamada A, Arakaki R, Saito M, Tsunematsu T, Kudo Y, Ishimaru N. A role of regulatory T cell in the pathogenesis of IBD. World J Gastroenterol. 2016 Feb21;22(7):2195-2205.

 

Kondo T, Tsunematsu T, Yamada A, Arakaki R, Saito M, Otsuka K, Kujiraoka S, Ushio A, Kurosawa M, Kudo Y, Ishimaru N. Acceleration of Tumor Growth due to Dysfunction in M1 Macrophages and Enhanced Angiogenesis in an Animal Model of Autoimmune Disease. Lab Invest. 2016 Jan 25.

 

Obayashi M, Yoshida M, Tsunematsu T, Ogawa I, Sasahira T, Kuniyasu H, Imoto I, Abiko Y, Xu D, Fukunaga S, Tahara H, Kudo Y, Nagao T, Takata T. MicroRNA-203 Suppresses Invasion and Epithelial-mesenchymal Transition Induction via Targeting NUAK1 and SNAI2 in Head and Neck Cancer. Oncotarget. 2016 Jan 22.

 

Saito M, Arakaki R, Yamada A, Tsunematsu T, Kudo Y, Ishimaru N. Molecular Mechanisms of Nickel Allergy. Int J Mol Sci. 2016 Feb 2;17(2).

 

Qi G, Kudo Y, Tang B, Liu T, Jin S, Liu J, Zuo X, Mi S, Shao W, Ma X, Tsunematsu T, Ishimaru N, Zeng S, Tstsuka M, Shimamoto F. PARP6 acts as a tumor suppressor via downregulating Survivin expression in colorectal cancer. Oncotarget. 2016 Feb 25.

 

Kudo Y, Tada H, Fujiwara N, Tada Y, Tsunematsu T, Miyake Y, Ishimaru N. Oral environment and cancer. Genes and environment (in press)

 

Tsunematsu T, Fujiwara N, Yoshida M, Takayama Y, Kujiraoka S, Qi G, Kitagawa M, Kondo T, Yamada A, Arakaki R, Miyauchi M, Ogawa I, Abiko Y, Nikawa H, Murakami S, Takata T, Ishimaru N, Kudo Y. Human odontogenic epithelial cells derived from epithelial rests of Malasses stem cell properities. Lab Invest (in press)

 

Izawa T, Arakaki R, Mori H, Tsunematsu T, Kudo Y, Tanaka E, Ishimaru N. The nuclear receptor AhR controls bone homeostasis by regulating osteoclast differentiation via the RANK/c-FOS signaling axis. J Immunol (in press)

 

Ando T, Kudo Y, Iizuka S, Tsunematsu T, Umehara H, Shrestha M, Matsuo T, Kubo T, Shimose S, Arihiro K, Ogawa I, Ochi M, Takata T. Ameloblastin induces tumor suppressive phenotype and enhances chemosensitivity to doxorubicin via Src-Stat3 inactivation in osteosarcoma. Sci. Rep (in press)

 

Qi G, Liu J, Mi S, Tsunematsu T, Jin S, Shao W, Liu T, Ishimaru N, Tang T, Kudo Y. Aurora kinase inhibitors in head and neck cancer. Curr. Top Med.Chem (in press)

 

Yang GX, Sun Y, Tsuneyama K, Zhang W, Leung PS, He XS, et al. Endogenous interleukin-22 protects against inflammatory bowel disease but not autoimmune cholangitis in dominant negative form of transforming growth factor beta receptor type II mice. Clin Exp Immunol. 2016;185(2):154-64.

Wakae H, Higashide T, Tsuneyama K, Nakamura T, Takahashi K, Sugiyama K. Immunohistochemical Characterization of the Ectopic Epithelium Devoid of Goblet Cells From a Posttraumatic Iris Cyst Causing Mucogenic Glaucoma. J Glaucoma. 2016;25(3):e291-4.

Takikawa A, Usui I, Fujisaka S, Ikutani M, Senda S, Hattori S, et al. Deletion of SIRT1 in myeloid cells impairs glucose metabolism with enhancing inflammatory response to adipose tissue hypoxia. Diabetology International. 2016;7(1):59-68.

Takikawa A, Mahmood A, Nawaz A, Kado T, Okabe K, Yamamoto S, et al. HIF-1alpha in Myeloid Cells Promotes Adipose Tissue Remodeling Toward Insulin Resistance. Diabetes. 2016;65(12):3649-59.

Takahashi T, Nishida T, Baba H, Hatta H, Imura J, Sutoh M, et al. Histopathological characteristics of glutamine synthetase-positive hepatic tumor lesions in a mouse model of spontaneous metabolic syndrome (TSOD mouse). Mol Clin Oncol. 2016;5(2):267-70.

Taira S, Yamaguchi N, Tatsuta Y, Katano H, Tsuneyama K, Kikuchi K. Liver disease risk of xenobiotics due to percutaneous absorption revealed by nano-PALDI imaging mass spectrometry. International Journal of Recent Scientific Research. 2016;7(7):12589-92.

Oda S, Shirai Y, Akai S, Nakajima A, Tsuneyama K, Yokoi T. Toxicological role of an acyl glucuronide metabolite in diclofenac-induced acute liver injury in mice. J Appl Toxicol. 2016.

Nishida T, Tsuneyama K, Fujimoto M, Nomoto K, Hayashi S, Miwa S, et al. Aberrant iron metabolism might have an impact on progression of diseases in Tsumura Suzuki obese diabetes mice, a model of spontaneous metabolic syndrome. Pathol Int. 2016;66(11):622-8.

 

Morimoto S, Ishikawa T, Hyodo K, Yamazaki T, Taira S, Tsuneyama K, et al. Preparation and characterization of newly developed matrix using functional γ‐Fe2O3 nanoparticles for mass spectrometry in small molecules. Surface and Interface Analysis. 2016;48:1127-31.

 

Kawaguchi M, Hara N, Bilim V, Koike H, Suzuki M, Kim TS, et al. A diagnostic marker for superficial urothelial bladder carcinoma: lack of nuclear ATBF1 (ZFHX3) by immunohistochemistry suggests malignant progression. BMC Cancer. 2016;16(1):805.

 

Iwamura A, Watanabe K, Akai S, Nishinosono T, Tsuneyama K, Oda S, et al. Zomepirac Acyl Glucuronide Is Responsible for Zomepirac-Induced Acute Kidney Injury in Mice. Drug Metab Dispos. 2016;44(7):888-96.

 

Ichimura M, Masuzumi M, Kawase M, Sakaki M, Tamaru S, Nagata Y, et al. A diet-induced Sprague-Dawley rat model of nonalcoholic steatohepatitis-related cirrhosis. J Nutr Biochem. 2016;40:62-9.

 

Bae HR, Leung PS, Tsuneyama K, Valencia JC, Hodge DL, Kim S, et al. Chronic expression of interferon-gamma leads to murine autoimmune cholangitis with a female predominance. Hepatology. 2016;64(4):1189-201.

 

Akai S, Uematsu Y, Tsuneyama K, Oda S, Yokoi T. Kupffer cell-mediated exacerbation of methimazole-induced acute liver injury in rats. J Appl Toxicol. 2016;36(5):702-15.

 

.

 

2015

<原著論文>

Takahashi T, Baba H, Hatta H, Ogawa H, Uehara H, Nishida Y, Kataguchi I, Tsuneyama K. Oral administration of α-lipoic acid increases serum levels of ascorbic acid and tocopherol: a pilot hematologyical study. Curr Top Nutraceutical Res. 2015, in press

 

Nakajima T, Yagi H, Baba H, Minamisaka T, Miwa S, Hayashi S, Nishida T, Hatta H, Tsuneyama K, Imura J. Complete Resolution of Pseudomalignant Erosion in a Reflux Gastroesophageal Polyp with Proton Pump Inhibitor. Case Rep Pathol. 2015; 657059.

 

Tsunashima H, Tsuneyama K, Moritoki Y, Hara M, Kikuchi K. Accumulated myeloid-derived suppressor cells demonstrate distinct phenotypes and functions in two non-alcoholic steatohepatitis mouse models. Hepatobiliary Surg Nutr. 2015 Oct;4(5):313-9. 

 

Wakae H, Higashide T, Tsuneyama K, Nakamura T, Takahashi K, Sugiyama K. Immunohistochemical Characterization of the Ectopic Epithelium Devoid of Goblet Cells From a Posttraumatic Iris Cyst Causing Mucogenic Glaucoma. J Glaucoma. 2015 Nov 6.

 

Yang JB, Wang YH, Yang W, Lu FT, Ma HD, Zhao ZB, Jia YJ, Tang W, Tsuneyama K, Ridgway WM, Gershwin ME, Lian ZX. Successful treatment of murine autoimmune cholangitis by parabiosis: Implications for hematopoietic therapy. J Autoimmun. 2015 Sep 29. pii: S0896-8411(15)30041-X. 

 

Sasaki E, Iida A, Oda S, Tsuneyama K, Fukami T, Nakajima M, Yokoi T. Pathogenetic analyses of carbamazepine-induced liver injury in F344 rats focused on immune- and inflammation-related factors. Exp Toxicol Pathol. 2016 Jan;68(1):27-38. 

 

Shinoda K, Taki H, Obayashi K, Ando Y, Watanabe A, Komiya A, Fuse H, Tsuneyama K, Tobe K. Wild-type ATTR amyloidosis of the ureter in a 56-year-old woman with rheumatoid arthritis and Sjögren's syndrome. Int J Clin Exp Pathol. 2015 Jul 1;8(7):8624-7. eCollection 2015. 

 

Nakajima T, Sugiyama T, Baba H, Hatta H, Nishida T, Miwa S, Hayashi S, Tsuneyama K, Imura J. Bone metastasis in gastrointestinal stromal tumors preferentially occurs in patients with original tumors in sites other than the stomach. Int J Clin Exp Pathol. 2015 May 1;8(5):5955-9. eCollection 2015. 

 

Tajiri K, Tsuneyama K, Kawai K, Atarashi Y, Minemura M, Sawada S, Tsukada K, Imura J, Sugiyama T. A case of progressing focal nodular hyperplasia and its molecular expression pattern. Clin J Gastroenterol. 2014 Jun;7(3):271-7. 

 

Cui ZG, Ogawa R, Tsuneyama K, Yan G, Tao L, Shimomura A, Inadera H. Insight into the molecular mechanism of heme oxygenase-1 induction by docosahexaenoic acid in U937 cells. Chem Biol Interact. 2015 Aug 5;238:180-8.

 

Hayashi S, Abe Y, Tomita S, Nakanishi Y, Miwa S, Nakajima T, Nomoto K,Tsuneyama K, Fujimori T, Imura J. Primary non-gestational pure choriocarcinoma arising in the ovary: A case report and literature review. Oncol Lett. 2015 May;9(5):2109-2111.

 

Lam YF, Tong KK, Kwan KM, Tsuneyama K, Shu SA, Leung PSC, Chu KH. Gastrointestinal Immune Response to the Shrimp Allergen Tropomyosin: Histological and Immunological Analysis in an Animal Model of Shrimp Tropomyosin Hypersensitivity. Int Arch Allergy Immunol., 2015; 167(1):29-40.

 

Gao F, Yokoyama S, Fujimoto M, Tsuneyama K, Saiki I, Shimada Y, Hayakawa Y. Comparison of two Kampo medicines in a diet-induced mouse obesity model. Traditional & Kampo med. 2015, in press

 

Akai S, Uematsu Y, Tsuneyama K, Oda S, YokoiT. Kupfferb cell-mediated exacerbation of methimazole-induced acute liver injury in rats. J Appl Toxicol, 2015 July 14.

 

Wada A, Ito A, Iitsuka H, Tsuneyama K, Miyazono T, Murakami J, Shibahara N, Sakurai H, Saiki I, Nakayama T, Yoshie O, Koizumi K, Sugiyama T. Role of chemokine CX3CL1 in progression of multiple myeloma via CX3CR1 in bone microenvironments. Oncol Rep. 2015 Jun;33(6):2935-9.

 

Takahashi K, Nagai N, Ogura K, Tsuneyama K, Saiki I, Irimura T, Hayakawa Y. Mammary tissue microenvironment determines T cell-dependent breast cancer-associated inflammation. Cancer Sci. 2015 Jul; 106(7):867-74.

 

Takai S, Oda S, Tsuneyama K, Fukami T, Nakajima M, Yokoi T. Establishment of a mouse model for amiodarone-induced liver injury and analyses of its hepatotoxic mechanism. J Appl Toxicol. 2016 jan; 36(1):35-47.

 

Iida A, Sasaki E, Yano A, Tsuneyama K, Fukami T, Nakajima M, Yokoi T.Carbamazepine-Induced Liver Injury Requires CYP3A-Mediated Metabolism and Glutathione Depletion in Rats. Drug Metab Dispos. 2015 Jul;43(7):958-68.

 

Gao F, Yokoyama S, Fujimoto M, Tsuneyama K, Saiki I, Shimada Y, Hayakawa Y. Effect of keishibukuryogan on genetic and dietary obesity models. Evid Based Complement Alternat Med. 2015;2015:801291.

 

Tanaka H, Yang GX, Tomiyama T, Tsuneyama K, Zhang W, Leung PS, Coppel RL, Joh T, Nadler SG, Ansari AA, Bowlus C, Gershwin ME. Immunological potential of cytotoxic T lymphocyte antigen 4 immunoglobulin in murine autoimmune cholangitis. Clin Exp Immunol. 2015 Jun;180(3):371-82.

 

Ichimura M, Hatanaka M, Tsuneyama K, Kato S, Omagari K. An SHR/NDmcr-cp Rat Model of Non-alcoholic steatohepatitis with advanced fibrosis induced by a High-fat, High-cholesterol Diet. J Obes Weight Loss There 2015, 5:1

 

Ikutani M, Tsuneyama K, Nakae S, Takatsu K. Emerging of IL-33 in inflammation and immune regulation. Inflammation and Regeneration 2015; 35(2), 69-77.

 

Ichimura M, Kawase M, Masuzumi M, Sakaki M, Nagata Y, Tanaka K, Suruga K, Tamaru S, Kato S, Tsuneyama K, Omagari K. High-fat and high-cholesterol diet rapidly induces non-alcoholic steatohepatitis with advanced fibrosis in Sprague-Dawley rats. Hepatol Res. 2015 Apr;45(4):458-69.

 

Takai S, Higuchi S, Yano A, Tsuneyama K, Fukami T, Nakajima M, Yokoi T.Involvement of immune- and inflammatory-related factors in flucloxacillin-induced liver injury in mice. J Appl Toxicol. 2015 Feb;35(2):142-51

 

Tezuka T, Ogawa H, Azuma M, Goto H, Uehara H, Aono Y, Hanibuchi M, Yamaguchi Y, Fujikawa T, Itai A, Nishioka Y.IMD-4690, a novel specific inhibitor for plasminogen activator inhibitor-1, reduces allergic airway remodeling in a mouse model of chronic asthma via regulating angiogenesis and remodeling-related mediators. PLoS One. 2015 Mar 18;10(3):e0121615.

 

Takahashi T, Uehara H, Ogawa H, Umemoto H, Bando Y, Izumi K.Inhibition of EP2/EP4 signaling abrogates IGF-1R-mediated cancer cell growth: involvement of protein kinase C-θ activation. Oncotarget. 2015 Mar 10;6(7):4829-44

 

Matsui T, Onouchi T, Shiogama K, Mizutani Y, Inada K, Yu F, Hayasaka D, Morita K, Ogawa H, Mahara F, Tsutsumi Y. Coated Glass Slides TACAS Are Applicable to Heat-Assisted Immunostaining and In Situ Hybridization at the Electron Microscopy Level. Acta Histochemica et Cytochemica 48(5) 2015.

 

Mitsuhashi A, Goto H, Saijo A, Trung VT, Aono Y, Ogino H, Kuramoto T, Tabata S, Uehara H, Izumi K, Yoshida M, Kobayashi H, Takahashi H, Gotoh M, Kakiuchi S, Hanibuchi M, Yano S, Yokomisa H, Sakiyama S, Nishioka Y. Fibrocyte-like cells mediate acquired resistance to anti-angiogenic therapy with bevacizumab. Nat Commun 6: 8792, 2015.

 

Takashima A, Yagi S, Yamaguchi K, Takagi E, Kanbara T, Ogawa H, Ise T, Kusunose K, Tobiume T, Yamada H, Soeki T, Wakatsuki T, Kitagawa T, Sata M, Vegetation of the Coronary Sinus that Concealed the Presence of a Coronary Arteriovenous Fistula in a Patient with Infectious Endocarditis, International Journal of Cardiology, letter to the editor2015.

 

 

<著書>

守時由起、菊池健太郎、常山幸一自己免疫性胆管炎:抗ミトコンドリア抗体陰性原発性胆汁性肝硬変免疫症候群(第2版)—その他の免疫疾患を含めて– 別冊日本臨床 新領域別症候群シリーズ No. 34, 369-374. 2015

佐々塚涼弥、馬場逸人、菊池健太郎、守時由起、常山幸一原発性胆汁性肝硬変の免疫病理 肝胆膵 71(5)831−837,2015

.

 

2014

Uehara H, Takahashi T, Oha M, Ogawa H, Izumi K, Exogenous fatty acid binding protein 4 promotes human prostate cancer cell progression.Int J Cancer. 2014 Dec 1;135(11):2558-68

Ogawa H, Ledford JG, Mukherjee S, Aono Y, Nishioka Y, Lee JJ, Izumi K, Hollingsworth JW. Surfactant protein D attenuates sub-epithelial fibrosis in allergic airways disease through TGF-β. Respir Res. 2014 Nov 29;15(1):143

Sato S, Hanibuchi M, Fukuya A, Yabuki Y, Bando H, Yoshijima T, Goto H, Ogawa H, Nishioka Y..Idiopathic pleuroparenchymal fibroelastosis is characterized by an elevated serum level of surfactant protein-D, but Not Krebs von den Lungen-6. Lung. 2014 Oct;192(5):711-7.

Aono Y, Kishi M, Yokota Y, Azuma M, Kinoshita K, Takezaki A, Sato S, Kawano H, Kishi J, Goto H, Uehara H, Izumi K, Nishioka Y. Role of PDGF/PDGFR axis in the trafficking of circulating fibrocytes in pulmonary fibrosis. Am J Respir Cell Mol Biol. 2014. 51(6):793-801,.

2013

 

Takahashi T, Uehara H, Izumi K. Inhibitory effect of soluble EP2 receptor on ovarian tumor growth in nude mice and utility of TMPRSS4 as a combinatorial molecular target. Int J Oncol. 2013 Aug;43(2):416-24.

Uehara H, Takahashi T, Izumi K. Induction of retinol-binding protein 4 and placenta-specific 8 expression in human prostate cancer cells remaining in bone following osteolytic tumor growth inhibition by osteoprotegerin. Int J Oncol. 2013 Aug;43(2):365-74.

Honjo A, Ogawa H, Azuma M, Tezuka T, Sone S, Biragyn A, Nishioka Y. Targeted reduction of CCR4+ cells is sufficient to suppress allergic inflammation. Respir Investig. 51(4):241-249, 2013.

Kinoshita K, Aono Y, Azuma M, Kishi J, Takezaki A, Kishi M, Makino H, Okazaki H, Uehara H, Izumi K, Sone S, Nishioka Y. Antifibrotic effects of focal adhesion klinase inhibitor in bleomycin-induced pulmonary fibrosis in mice. Am J Respir Cell Mol Biol. 49(4):536-543, 2013.

Yamada T, Takeuchi S, Fujita N, Nakamura A, Wang W, Li Q, Oda M, Mitsudomi T, Yatabe Y, Sekido Y, Yoshida J, Higashiyama M, Noguchi M, Uehara H, Nishioka Y, Sone S, Yano S. Akt kinase -interacting protein1, a novel therapeutic target for lung cancer with EGFR-activating and gatekeeper mutations. Oncogene. 32(37):4427-4435, 2013.

Mitsuhashi A, Goto H, Kuramoto T, Tabata S, Yukishige S, Abe S, Hanibuchi M, Kakiuchi S, Saijo A, Aono Y, Uehara H, Yano S, Ledford JG, Sone S, Nishioka Y. Surfactant protein A suppresses lung cancer progression by regulating the polarization of tumor-associated macrophages. Am J Pathol. 182(5):1843-1853, 2013.

Sato S, Hanibuchi M, Kuramoto T, Yamamori N, Goto H, Ogawa H, Mitsuhashi A, Van TT, Kakiuchi S, Akiyama SI, Nishioka Y, Sone S. Macrophage stimulating protein promotes liver metastases of small cell lung cancer cells by affecting the organ microenvironment. Clin Exp Metastasis. 30(3):333-344, 2013.

Makino H, Aono Y, Azuma M, Kishi M, Yokota Y, Kinoshita K, Takezaki A, Kishi J, Kawano H, Ogawa H, Uehara H, Izumi K, Sone S, Nishioka Y. Antifibrotic effects of CXCR4 antagonist in bleomycin -induced pulmonary fibrosis in mice. J Med Invest. 60(1-2):127-137, 2013.

その他の記事...

  1. 2012

  2. 2011

  3. 2010

  4. 2009