1. Overview of this Document

1) The Role Delineation Document is comprised of six Domains.

Domain 1	Management of Spontaneous and Experimentally Induced Diseases and Conditions
Domain 2	Management of Pain and Distress
Domain 3	Research
Domain 4	Animal Care
Domain 5	Regulatory Responsibilities
Domain 6	Education

2) Each Domain is composed of Tasks and Knowledge topics.

	Tasks	Knowledges
During a DVM program	None	Some of the topics have been acquired for DVM licensed subject
At time of certification	Most of the tasks have been performed by an JCLAM Diplomate	Most of the knowledge were required
Either on the job or in a continuing education setting after certification	Some of the tasks were performed predominantly	Some of the knowledges have been acquired predominantly

2. Tasks and Knowledge topics for each Domain

Domain 1: Management of Spontaneous and Experimentally Induced Diseases and Conditions

	Tasks	Knowledges
During a DVM program	None	K1. diagnostic procedures  a. conduct of a physical examination  b. clinical pathology c. other diagnostic procedures K2. surgical techniques associated with diagnostic and therapeutic surgeries  K3. immunobiology K4. nutrition with emphasis on effects of deficiency or toxicity K5. anatomy with emphasis on features which have significance with regard to clinical medicine or experimental medicine K6. physiology with emphasis on normative data and characteristics, metabolic differences or metabolism of induced disease, reproductive physiology, and clinically significant physiological features K7. parasitology with emphasis on parasitic diseases that can become established in a colony and zoonotic parasitic diseases K8. microbiology with emphasis on organisms of clinical significance; subclinical infections that cause physiologic, biochemical, and/or immunologic alterations; zoonotic disease organisms; organisms used experimentally to induce infection and unintended infections; and sampling and culture techniques for such organisms  K9. anatomic pathology including pathogenesis of significant naturally occurring and experimentally induced diseases; typical gross and histopathologic lesions; and pertinent anatomic pathology techniques  K10. pharmacology with emphasis on drugs used to treat spontaneous or induced disease, and drugs used to induce disease
At time of certification	T1. prevent spontaneous or unintended disease or condition  T2. control spontaneous or unintended disease or condition  T3. diagnose disease or condition as appropriate T4. treat disease or condition as appropriate	K11. epidemiology including species-specific susceptibility to induced disease K12. preventive medicine  K13. diagnostic procedures  a. species-specific behavioral assessment  b. serologic, cytologic, and molecular diagnostic tests and proper sampling techniques K14. genetics with emphasis on control and treatment of naturally occurring and experimentally induced disease, predisposition to disease, and modes of inheritance

Domain 2: Management of Pain and Distress

	Tasks	Knowledges
During a DVM program	None	K1. anatomy and physiology of pain and distress  K2. patient monitoring  K3. critical and post-procedural care techniques K4. pharmacological interventions for pain and distress and their effects on physiology, including age and species differences for such interventions, and depth and duration of analgesia provided by such interventions  K5. euthanasia
At time of certification	T1. recognize pain and/or distress  T2. minimize or eliminate pain and/or distress  T3. administration of anesthesia T4. euthanatize (euthanize)	K6. assessment of pain and distress K7. causes of pain  K8. causes of distress  K9. effects of pain and distress on normative physiology and on research studies  K10. nonpharmacological interventions for pain and distress and their effects on physiology, including age and species differences for such interventions  K11. humane endpoint criteria

Domain 3: Research

	Tasks	Knowledges
During a DVM program	None	K1. research methods and equipment K2. principles of experimental design and statistics including scientific method K3. animal models including normative biology relevant to the research K4. characterization of animal models K5. genetics and nomenclature K6. genetic modification/engineering technology including application of molecular biology techniques
At time of certification	T1. facilitate or provide research support  T2. advise and consult with investigators on matters related to their research  T3. design and conduct research	K7. biomethodology techniques K8. gnotobiotics  K9. experimental surgical techniques and instrumentation  K10. information resources  K11. scientific writing  K12. Replacement, Reduction and Refinement techniques  K13. Effective methods for communicating research-related concerns  K14. Aseptic requirements for performing surgery  K15. genomics, metabolomics, and proteomics
After certification	T4. collaborate with other scientists on research projects	K16. grant application, review and funding mechanisms

Domain 4: Animal Care

	Tasks	Knowledges
During a DVM program	None	K1. species-specific husbandry K2. methods of sterilization, sanitation, and decontamination K3. breeding colony management K4. animal identification systems  K5. pest control K6. environmental causes of physiological alterations in animals and their effects on research K7. environmental monitoring K8. watering and feeding
At time of certification	T1. develop animal husbandry programs  T2. manage or provide indirect management/oversight of animal husbandry programs  T3. manage or provide indirect management/oversight of laboratory animal facilities	K9. environmental enrichment, species-appropriate behavioral and psychosocial needs including creation and maintenance of appropriate social pairs or groups  K10. quality assurance techniques for animal care-related equipment and supplies K11. animal procurement considerations K12. pathogen-free barriers, maintenance of pathogen-free colonies via sentinel use and surveillance programs K13. containment facilities
After certification	T4. design laboratory animal facilities	K14. selection criteria for animal care-related equipment and supplies  K15. fiscal management as it relates to budgetary and financial issues associated with animal facility management K16. human resource management as it relates to operation of animal care and use programs  K17. disaster planning  K18. facility planning, design, and construction K19. mechanical, electrical and plumbing systems  K20. waste management  K21. housing systems

Domain 5: Regulatory Responsibilities

	Tasks	Knowledges
During a DVM program	None	K1. laws, regulations, policies and standards a. Pharmaceuticals and Medical Devices Act b. Welfare and Management of Animals Act c. Invasive Alien Species Act d. Cartagena Law e. Narcotics and Psychotropics Control Act f. Infectious Disease Control Law g. Domestic Animal Infectious Diseases Control Act h. Rendering Plant Law i. Rabies Prevention Act j. Protection and Control of Wild Birds and Mammals and Hunting Management Law k. Conservation of Endangered Species of Wild Fauna and Flora Act l. Industrial Safety and Health Act m. Agricultural Chemicals Regulation Law n. Evaluation of Chemical Substances and Regulation of Their Manufactures Law
At time of certification	T1. perform direct or delegated Attending Veterinarian responsibilities T2. advocate for humane care and use of animals T3. provide advice to occupational health and safety programs T4. provide advice on biological, chemical and radiation hazards in an animal research program T5. serve as a member of an IACUC T6. review protocols and provide advice to investigators and the IACUC	K2. laws, regulations, policies and standards a. Good Laboratory Practices K3. international laws, regulations, policies and standards a. Guide for the Care and Use of Laboratory Animals (ILAR/NRC) b. AVMA Guidelines for the Euthanasia of Animals (AVMA)  K4. role and function of the IACUC  K5. protocol review
After certification	None	K6. international laws, policies, and standards a. Animal Welfare Act, USDA regulations, Animal Care policies  b. Health Research Extension Act, Public Health Service Policy on Humane Care and Use of Laboratory Animals, OLAW interpretive guidance  c. Biosafety in Microbiological and Biomedical Laboratories d. Endangered Species Act/CITES  e. Guide for the Care and Use of Agricultural Animals in Agricultural Research and Teaching (FASS) f. Live Animals Regulations (IATA – International Air Transportation Association) g. USDA and CDC animal importation regulations  h. NIH Recombinant DNA Guidelines and Office of Biotechnology i. Occupational Health and Safety in the Care and Use of Research Animals (ILAR/NRC)

Domain 6: Education

	Tasks	Knowledges
During a DVM program	None	K1. societal issues involving use of animals:  a. philosophy and ethics of animal used. history and value of animal research
At time of certification	T1. train personnel in animal care and use T2. maintain current knowledge and continued competence in laboratory animal medicine	K2. educational resources K3. certification programs (e.g., DJCLAM certification)  K4. societal issues involving use of animals:  a. organizations related to and/or supportive of laboratory animal medicine and animal research (e.g., JALAS, JSVS, JALAM, JSAAE, ILAR) b. organizations opposed to animal research (e.g., AVA-Net, ALIVE, PETA, HSUS) including their philosophy and opposition strategies
After certification	T3. provide education in academic and/or laboratory animal residency programs  T4. outside of formal training programs, mentor those interested in or involved in laboratory animal medicine T5. provide community outreach on animal care and use	None

JALAS: Japanese Association for Laboratory Animal Science; JSVS: Japanese Society of Veterinary Science; JALAM: Japanese Association for Laboratory Animal Medicine; JSAAE: Japanese Society for Alternatives to Animal Experiments; ILAR: Institute for Laboratory Animal Research; AVA-Net: Anti-vivisection Action Network; ALIVE: All Life in a Viable Environment; PETA: People for the Ethical Treatment of Animals; HSUS: Humane Society of the United States





Species Categories

The suggested species were classified as primary, and secondary. Below is the list by category.

Category	Species
Primary	P1. Mouse (Mus musculus) P2. Rat (Rattus norvegicus) P3. Rabbit (Oryctolagus cuniculus)  P4. Dog (Canis familiaris) P5. Pig (Sus scrofa) P6. Macaques (Macaca spp)
Secondary	S1. Guinea pig (Cavia porcellus) S2. Syrian hamster (Mesocricetus auratus) S3. Gerbil (Meriones spp.) S4. Other rodents S5. Cat (Felis domestica) S6. Ferret (Mustela putorius furo) S7. Sheep (Ovis aries) S8. Goat (Capra hircus)  S9. Cow (Bos taurus) S10. Horse (Equus caballus) S11. Squirrel monkey (Saimiri sciureus) S12. Marmoset/tamarins (Callitrichidae) S13. Another nonhuman primate S14. Chicken (Gallus domestica) S15. Japanese quail (Cotunix japonica) S16. Other birds S17. Zebrafish (Danio rerio) S18. Carp (Cyprinus carpio) S19. Japanese killifish (Oryzias latipes) S20. Other fish S21. African clawed frog (Xenopus laevis and Xenopus tropicalis) S22. Invertebrates including drosophila and nematode

Last Revised on Novenber 19, 2022.

1. Overview of this Document

1) The Role Delineation Document is comprised of six Domains.

Domain 1	Management of Spontaneous and Experimentally Induced Diseases and Conditions
Domain 2	Management of Pain and Distress
Domain 3	Research
Domain 4	Animal Care
Domain 5	Regulatory Responsibilities
Domain 6	Education

2) Each Domain is composed of Tasks and Knowledge topics.

	Tasks	Knowledges
During a DVM program	None	Some of the topics have been acquired for DVM licensed subject
At time of certification	Most of the tasks have been performed by an JCLAM Diplomate	Most of the knowledge were required
Either on the job or in a continuing education setting after certification	Some of the tasks were performed predominantly	Some of the knowledges have been acquired predominantly

2. Tasks and Knowledge topics for each Domain

Domain 1: Management of Spontaneous and Experimentally Induced Diseases and Conditions

	Tasks	Knowledges
During a DVM program	None	K1. diagnostic procedures  a. conduct of a physical examination  b. clinical pathology c. other diagnostic procedures K2. surgical techniques associated with diagnostic and therapeutic surgeries  K3. immunobiology K4. nutrition with emphasis on effects of deficiency or toxicity K5. anatomy with emphasis on features which have significance with regard to clinical medicine or experimental medicine K6. physiology with emphasis on normative data and characteristics, metabolic differences or metabolism of induced disease, reproductive physiology, and clinically significant physiological features K7. parasitology with emphasis on parasitic diseases that can become established in a colony and zoonotic parasitic diseases K8. microbiology with emphasis on organisms of clinical significance; subclinical infections that cause physiologic, biochemical, and/or immunologic alterations; zoonotic disease organisms; organisms used experimentally to induce infection and unintended infections; and sampling and culture techniques for such organisms  K9. anatomic pathology including pathogenesis of significant naturally occurring and experimentally induced diseases; typical gross and histopathologic lesions; and pertinent anatomic pathology techniques  K10. pharmacology with emphasis on drugs used to treat spontaneous or induced disease, and drugs used to induce disease
At time of certification	T1. prevent spontaneous or unintended disease or condition  T2. control spontaneous or unintended disease or condition  T3. diagnose disease or condition as appropriate T4. treat disease or condition as appropriate	K11. epidemiology including species-specific susceptibility to induced disease K12. preventive medicine  K13. diagnostic procedures  a. species-specific behavioral assessment  b. serologic, cytologic, and molecular diagnostic tests and proper sampling techniques K14. genetics with emphasis on control and treatment of naturally occurring and experimentally induced disease, predisposition to disease, and modes of inheritance

Domain 2: Management of Pain and Distress

	Tasks	Knowledges
During a DVM program	None	K1. anatomy and physiology of pain and distress  K2. patient monitoring  K3. critical and post-procedural care techniques K4. pharmacological interventions for pain and distress and their effects on physiology, including age and species differences for such interventions, and depth and duration of analgesia provided by such interventions  K5. euthanasia
At time of certification	T1. recognize pain and/or distress  T2. minimize or eliminate pain and/or distress  T3. administration of anesthesia T4. euthanatize (euthanize)	K6. assessment of pain and distress K7. causes of pain  K8. causes of distress  K9. effects of pain and distress on normative physiology and on research studies  K10. nonpharmacological interventions for pain and distress and their effects on physiology, including age and species differences for such interventions  K11. humane endpoint criteria

Domain 3: Research

	Tasks	Knowledges
During a DVM program	None	K1. research methods and equipment K2. principles of experimental design and statistics including scientific method K3. animal models including normative biology relevant to the research K4. characterization of animal models K5. genetics and nomenclature K6. genetic modification/engineering technology including application of molecular biology techniques
At time of certification	T1. facilitate or provide research support  T2. advise and consult with investigators on matters related to their research  T3. design and conduct research	K7. biomethodology techniques K8. gnotobiotics  K9. experimental surgical techniques and instrumentation  K10. information resources  K11. scientific writing  K12. Replacement, Reduction and Refinement techniques  K13. Effective methods for communicating research-related concerns  K14. Aseptic requirements for performing surgery  K15. genomics, metabolomics, and proteomics
After certification	T4. collaborate with other scientists on research projects	K16. grant application, review and funding mechanisms

Domain 4: Animal Care

	Tasks	Knowledges
During a DVM program	None	K1. species-specific husbandry K2. methods of sterilization, sanitation, and decontamination K3. breeding colony management K4. animal identification systems  K5. pest control K6. environmental causes of physiological alterations in animals and their effects on research K7. environmental monitoring K8. watering and feeding
At time of certification	T1. develop animal husbandry programs  T2. manage or provide indirect management/oversight of animal husbandry programs  T3. manage or provide indirect management/oversight of laboratory animal facilities	K9. environmental enrichment, species-appropriate behavioral and psychosocial needs including creation and maintenance of appropriate social pairs or groups  K10. quality assurance techniques for animal care-related equipment and supplies K11. animal procurement considerations K12. pathogen-free barriers, maintenance of pathogen-free colonies via sentinel use and surveillance programs K13. containment facilities
After certification	T4. design laboratory animal facilities	K14. selection criteria for animal care-related equipment and supplies  K15. fiscal management as it relates to budgetary and financial issues associated with animal facility management K16. human resource management as it relates to operation of animal care and use programs  K17. disaster planning  K18. facility planning, design, and construction K19. mechanical, electrical and plumbing systems  K20. waste management  K21. housing systems

Domain 5: Regulatory Responsibilities

	Tasks	Knowledges
During a DVM program	None	K1. laws, regulations, policies and standards a. Pharmaceuticals and Medical Devices Act b. Welfare and Management of Animals Act c. Invasive Alien Species Act d. Cartagena Law e. Narcotics and Psychotropics Control Act f. Infectious Disease Control Law g. Domestic Animal Infectious Diseases Control Act h. Rendering Plant Law i. Rabies Prevention Act j. Protection and Control of Wild Birds and Mammals and Hunting Management Law k. Conservation of Endangered Species of Wild Fauna and Flora Act l. Industrial Safety and Health Act m. Agricultural Chemicals Regulation Law n. Evaluation of Chemical Substances and Regulation of Their Manufactures Law
At time of certification	T1. perform direct or delegated Attending Veterinarian responsibilities T2. advocate for humane care and use of animals T3. provide advice to occupational health and safety programs T4. provide advice on biological, chemical and radiation hazards in an animal research program T5. serve as a member of an IACUC T6. review protocols and provide advice to investigators and the IACUC	K2. laws, regulations, policies and standards a. Good Laboratory Practices K3. international laws, regulations, policies and standards a. Guide for the Care and Use of Laboratory Animals (ILAR/NRC) b. AVMA Guidelines for the Euthanasia of Animals (AVMA)  K4. role and function of the IACUC  K5. protocol review
After certification	None	K6. international laws, policies, and standards a. Animal Welfare Act, USDA regulations, Animal Care policies  b. Health Research Extension Act, Public Health Service Policy on Humane Care and Use of Laboratory Animals, OLAW interpretive guidance  c. Biosafety in Microbiological and Biomedical Laboratories d. Endangered Species Act/CITES  e. Guide for the Care and Use of Agricultural Animals in Agricultural Research and Teaching (FASS) f. Live Animals Regulations (IATA – International Air Transportation Association) g. USDA and CDC animal importation regulations  h. NIH Recombinant DNA Guidelines and Office of Biotechnology i. Occupational Health and Safety in the Care and Use of Research Animals (ILAR/NRC)

Domain 6: Education

	Tasks	Knowledges
During a DVM program	None	K1. societal issues involving use of animals:  a. philosophy and ethics of animal used. history and value of animal research
At time of certification	T1. train personnel in animal care and use T2. maintain current knowledge and continued competence in laboratory animal medicine	K2. educational resources K3. certification programs (e.g., DJCLAM certification)  K4. societal issues involving use of animals:  a. organizations related to and/or supportive of laboratory animal medicine and animal research (e.g., JALAS, JSVS, JALAM, JSAAE, ILAR) b. organizations opposed to animal research (e.g., AVA-Net, ALIVE, PETA, HSUS) including their philosophy and opposition strategies
After certification	T3. provide education in academic and/or laboratory animal residency programs  T4. outside of formal training programs, mentor those interested in or involved in laboratory animal medicine T5. provide community outreach on animal care and use	None

JALAS: Japanese Association for Laboratory Animal Science; JSVS: Japanese Society of Veterinary Science; JALAM: Japanese Association for Laboratory Animal Medicine; JSAAE: Japanese Society for Alternatives to Animal Experiments; ILAR: Institute for Laboratory Animal Research; AVA-Net: Anti-vivisection Action Network; ALIVE: All Life in a Viable Environment; PETA: People for the Ethical Treatment of Animals; HSUS: Humane Society of the United States





Species Categories

The suggested species were classified as primary, and secondary. Below is the list by category.

Category	Species
Primary	P1. Mouse (Mus musculus) P2. Rat (Rattus norvegicus) P3. Rabbit (Oryctolagus cuniculus)  P4. Dog (Canis familiaris) P5. Pig (Sus scrofa) P6. Macaques (Macaca spp)
Secondary	S1. Guinea pig (Cavia porcellus) S2. Syrian hamster (Mesocricetus auratus) S3. Gerbil (Meriones spp.) S4. Other rodents S5. Cat (Felis domestica) S6. Ferret (Mustela putorius furo) S7. Sheep (Ovis aries) S8. Goat (Capra hircus)  S9. Cow (Bos taurus) S10. Horse (Equus caballus) S11. Squirrel monkey (Saimiri sciureus) S12. Marmoset/tamarins (Callitrichidae) S13. Another nonhuman primate S14. Chicken (Gallus domestica) S15. Japanese quail (Cotunix japonica) S16. Other birds S17. Zebrafish (Danio rerio) S18. Carp (Cyprinus carpio) S19. Japanese killifish (Oryzias latipes) S20. Other fish S21. African clawed frog (Xenopus laevis and Xenopus tropicalis) S22. Invertebrates including drosophila and nematode

Last Revised on Novenber 19, 2022.