Tuesday, October 23

9:00-9:05 Opening remarks
Session 1. Phosphatases in development and homeostasis
9:05-9:40 David L. Brautigan, University of Virginia, USA
The SAPS subunits for Protein Ser/Thr Phosphatase-6
9:40-10:00 Toshio Watanabe, Nara Women's University, Japan
Tissue Specific Deletion of Protein Phosphatase 6 Catalytic Subunit (Ppp6c) Caused Embryonic lethality and postnatal death.
10:00-10:30 Antje Gohla, University of Würzburg, Germany
Improved cognition, mild anxiety-like behavior and decreased motor performance in pyridoxal phosphatase-deficient mice
10:30-10:45 Break
10:45-11:10 Kohsuke Takeda, Nagasaki University, Japan
Mechanisms linking mitochondrial stress sensing to cellular response
11:10-11:25 Satoru Torii, Tokyo Medical and Dental University, Japan
The role of PPM1D in regulating DNA damage-induced autophagy
11:25-11:45 Tatsuya Maeda, Hamamatsu University School of Medicine, Japan
The glutamine-responsive TORC1 activation mechanism in yeast
11:45-12:00 Seiji Torii, Gumma University, Japan
The secretory granule-resident pseudophosphatase phogrin enables glucose-stimulated insulin signaling in pancreatic β-cells
12:00- Lunch
Session 2. Phosphatases in Cellular Regulation
13:10-13:45 Mathieu Bollen, University of Leuven, Belgium
The phosphatase scaffold RepoMan: spatiotemporal regulation and substrate diversity
13:45-14:15 Hemmo Meyer, University of Duisburg-Essen, Germany
Regulation of PP1 by the AAA+ ATPase VCP/p97
14:15-14:45 Thomas Mayer, University of Konstanz, Germany
Calcineurin promotes APC/C activation at meiotic exit by acting on both XErp1 and Cdc20
14:45-15:10 Mikiko Sodeoka, RIKEN, Japan
Development of CDC25A/B-selective Inhibitor RE44
15:10-15:30 Break
Session 3. Cardiac and Neuronal Functions
15:30-16:05 Tzu-Ching Meng Academia Sinica, Taiwan
Repurposing Auranofin for the Therapeutic Intervention in Acute Myocardial Infraction via Targeting PTP-PEST
16:05-16:35 Ali El-Armouche, Technical University Dresden, Germany
Protein Phosphatases in the Healthy and Diseased Heart
16:35-16:50 Fumio Nakamura, Yokohama City University, Japan
PTPδ mediates Semaphorin-3A-induced dendritic growth of cortical pyramidal neurons.
16:50-17:05 Atsushi Yamagata, University of Tokyo, Japan
Splicing-dependent regulation of the interaction between PTPδ and postsynaptic organizers
17:05-17:25 Hiroshi Ohnishi, Gunma University, Japan
Regulation of microglia activation and tissue damage in white matter by a cell-cell contact signal
Presentation of Young Investigator Award from Japanese Association of Protein Phosphatase
17:25-17:45 Yasuyuki Saito, Kobe University
SIRPα+ dendritic cells regulate homeostasis of fibroblastic reticular cells via TNF receptor ligands in the adult spleen

Wednesday, October 24

Session 4. Phosphatases and Cancer (1)
9:00-9:35 Benjamin G. Neel, New York University, USA
Targeting SHP2 in Cancer
9:35-10:05 Frank-Dietmar Böhmer, University of Jena, Germany
PTP Oxidation in Cells of FLT3ITD-positive Acute Myeloid Leukemia: Mechanism and Biological Consequences
10:05-10:30 Masanori Hatakeyama, The University of Tokyo, Japan
Parafibromin inversely regulates the Hippo signal effectors YAP and TAZ depending on its tyrosine phosphorylation status
10:30-10:45 Break
10:45-11:05 Reiko Sugiura, Kindai University, Japan
Selective killing of cancer cells by ACA-28, a small molecule inducing ERK-dependent apoptosis~ A novel cancer therapy to stimulate oncogenic ERK signaling~
11:05-11:30 Takehiko Sasaki, Tokyo Medical and Dental University, Japan
The lipid phosphatase INPP4B is a tumor suppressor in the context of PTEN insufficiency
11:30-11:45 Takeshi Ijuin, Kobe University, Japan
Roles of Phosphoinositide 5-Phosphatase SHIP2 in focal adhesion turnover depend on cancer cell types
11:45- Lunch
12:15-14:45 Poster session
14:45-15:15 Maja Köhn, University of Freiburg, Germany
The cancer-promoting phosphatase PRL-3 in endocytosis and cell polarity
15:15-15:30 Noriko Uetani, McGill University, Canada
PRL2 links magnesium flux and sex-dependent circadian metabolic rhythms
15:30-15:45 Yosuke Funato, Osaka University, Japan
Regulation of Mg2+ homeostasis and cancer progression by Phosphatase of Regenerating Liver (PRL)
15:45-16:00 Min Wei, University of Kentucky, USA
Phosphatase PRL-3: a potential therapeutic target in T-cell Acute Lymphoblastic Leukemia
16:00-16:20 Break
Session 5. Phosphatases and Cancer (2)
16:20-16:55 Nicholas Tonks Cold Spring Harbor Laboratory, USA
New approaches to exploiting PTP1B as a therapeutic target
16:55-17:15 Yoshiro Chuman, Niigata University, Japan
Specific Inhibitors for Oncogenic PPM1D Phosphatase Using ion-responsive DNA aptamer (IRDAptamer)
17:15-17:40 Hiroshi Shima, Miyagi Cancer Center, Japan
Tumor suppressor activity of protein phosphatase 6
17:40-18:05 Takashi Ohama, Yamaguchi University, Japan
The role of SET/I2PP2A in Gastric Cancer
18:30-20:30 Reception

Thursday, October 25

Session 6. Immunity and Immunotherapy
9:00-9:35 Michel Tremblay, McGill University, Canada
Enhancing antitumoral activity of cell based immunotherapies by modulating the JAK-STAT axis.
9:35-10:00 Takashi Matozaki, Kobe University, Japan
Role of the tyrosine phosphorylation signal in homeostasis of intestinal epithelium and its relation to inflammation and cancer
10:00-10:30 Roland Lang, University Clinic Erlangen, Germany
Regulation of innate immunity by DUSP family members
10:30-10:45 Break
10:45-11:05 Takeshi Tsubata, Tokyo Medical and Dental University, Tokyo
SHP-1-activating receptors and autoimmune diseases
11:05-11:35 Jürgen Wienands, University of Göttingen, Germany
Intrinsic Control of Positive and Negative Signal Loops by the B Cell Antigen Receptor
11:35-11:45 Closing remarks