PROGRAM
Tuesday, October 23
| 9:00-9:05 | Opening remarks |
| Session 1. Phosphatases in development and homeostasis | |
| 9:05-9:40 | David L. Brautigan, University of Virginia, USA The SAPS subunits for Protein Ser/Thr Phosphatase-6 |
| 9:40-10:00 | Toshio Watanabe, Nara Women's University, Japan Tissue Specific Deletion of Protein Phosphatase 6 Catalytic Subunit (Ppp6c) Caused Embryonic lethality and postnatal death. |
| 10:00-10:30 | Antje Gohla, University of Würzburg, Germany Improved cognition, mild anxiety-like behavior and decreased motor performance in pyridoxal phosphatase-deficient mice |
| 10:30-10:45 | Break |
| 10:45-11:10 | Kohsuke Takeda, Nagasaki University, Japan Mechanisms linking mitochondrial stress sensing to cellular response |
| 11:10-11:25 | Satoru Torii, Tokyo Medical and Dental University, Japan The role of PPM1D in regulating DNA damage-induced autophagy |
| 11:25-11:45 | Tatsuya Maeda, Hamamatsu University School of Medicine, Japan The glutamine-responsive TORC1 activation mechanism in yeast |
| 11:45-12:00 | Seiji Torii, Gumma University, Japan The secretory granule-resident pseudophosphatase phogrin enables glucose-stimulated insulin signaling in pancreatic β-cells |
| 12:00- | Lunch |
| Session 2. Phosphatases in Cellular Regulation | |
| 13:10-13:45 | Mathieu Bollen, University of Leuven, Belgium The phosphatase scaffold RepoMan: spatiotemporal regulation and substrate diversity |
| 13:45-14:15 | Hemmo Meyer, University of Duisburg-Essen, Germany Regulation of PP1 by the AAA+ ATPase VCP/p97 |
| 14:15-14:45 | Thomas Mayer, University of Konstanz, Germany Calcineurin promotes APC/C activation at meiotic exit by acting on both XErp1 and Cdc20 |
| 14:45-15:10 | Mikiko Sodeoka, RIKEN, Japan Development of CDC25A/B-selective Inhibitor RE44 |
| 15:10-15:30 | Break |
| Session 3. Cardiac and Neuronal Functions | |
| 15:30-16:05 | Tzu-Ching Meng Academia Sinica, Taiwan Repurposing Auranofin for the Therapeutic Intervention in Acute Myocardial Infraction via Targeting PTP-PEST |
| 16:05-16:35 | Ali El-Armouche, Technical University Dresden, Germany Protein Phosphatases in the Healthy and Diseased Heart |
| 16:35-16:50 | Fumio Nakamura, Yokohama City University, Japan PTPδ mediates Semaphorin-3A-induced dendritic growth of cortical pyramidal neurons. |
| 16:50-17:05 | Atsushi Yamagata, University of Tokyo, Japan Splicing-dependent regulation of the interaction between PTPδ and postsynaptic organizers |
| 17:05-17:25 | Hiroshi Ohnishi, Gunma University, Japan Regulation of microglia activation and tissue damage in white matter by a cell-cell contact signal |
| Presentation of Young Investigator Award from Japanese Association of Protein Phosphatase | |
| 17:25-17:45 | Yasuyuki Saito, Kobe University SIRPα+ dendritic cells regulate homeostasis of fibroblastic reticular cells via TNF receptor ligands in the adult spleen |
Wednesday, October 24
| Session 4. Phosphatases and Cancer (1) | |
| 9:00-9:35 | Benjamin G. Neel, New York University, USA Targeting SHP2 in Cancer |
| 9:35-10:05 | Frank-Dietmar Böhmer, University of Jena, Germany PTP Oxidation in Cells of FLT3ITD-positive Acute Myeloid Leukemia: Mechanism and Biological Consequences |
| 10:05-10:30 | Masanori Hatakeyama, The University of Tokyo, Japan Parafibromin inversely regulates the Hippo signal effectors YAP and TAZ depending on its tyrosine phosphorylation status |
| 10:30-10:45 | Break |
| 10:45-11:05 | Reiko Sugiura, Kindai University, Japan Selective killing of cancer cells by ACA-28, a small molecule inducing ERK-dependent apoptosis~ A novel cancer therapy to stimulate oncogenic ERK signaling~ |
| 11:05-11:30 | Takehiko Sasaki, Tokyo Medical and Dental University, Japan The lipid phosphatase INPP4B is a tumor suppressor in the context of PTEN insufficiency |
| 11:30-11:45 | Takeshi Ijuin, Kobe University, Japan Roles of Phosphoinositide 5-Phosphatase SHIP2 in focal adhesion turnover depend on cancer cell types |
| 11:45- | Lunch |
| 12:15-14:45 | Poster session |
| 14:45-15:15 | Maja Köhn, University of Freiburg, Germany The cancer-promoting phosphatase PRL-3 in endocytosis and cell polarity |
| 15:15-15:30 | Noriko Uetani, McGill University, Canada PRL2 links magnesium flux and sex-dependent circadian metabolic rhythms |
| 15:30-15:45 | Yosuke Funato, Osaka University, Japan Regulation of Mg2+ homeostasis and cancer progression by Phosphatase of Regenerating Liver (PRL) |
| 15:45-16:00 | Min Wei, University of Kentucky, USA Phosphatase PRL-3: a potential therapeutic target in T-cell Acute Lymphoblastic Leukemia |
| 16:00-16:20 | Break |
| Session 5. Phosphatases and Cancer (2) | |
| 16:20-16:55 | Nicholas Tonks Cold Spring Harbor Laboratory, USA New approaches to exploiting PTP1B as a therapeutic target |
| 16:55-17:15 | Yoshiro Chuman, Niigata University, Japan Specific Inhibitors for Oncogenic PPM1D Phosphatase Using ion-responsive DNA aptamer (IRDAptamer) |
| 17:15-17:40 | Hiroshi Shima, Miyagi Cancer Center, Japan Tumor suppressor activity of protein phosphatase 6 |
| 17:40-18:05 | Takashi Ohama, Yamaguchi University, Japan The role of SET/I2PP2A in Gastric Cancer |
| 18:30-20:30 | Reception |
Thursday, October 25
| Session 6. Immunity and Immunotherapy | |
| 9:00-9:35 | Michel Tremblay, McGill University, Canada Enhancing antitumoral activity of cell based immunotherapies by modulating the JAK-STAT axis. |
| 9:35-10:00 | Takashi Matozaki, Kobe University, Japan Role of the tyrosine phosphorylation signal in homeostasis of intestinal epithelium and its relation to inflammation and cancer |
| 10:00-10:30 | Roland Lang, University Clinic Erlangen, Germany Regulation of innate immunity by DUSP family members |
| 10:30-10:45 | Break |
| 10:45-11:05 | Takeshi Tsubata, Tokyo Medical and Dental University, Tokyo SHP-1-activating receptors and autoimmune diseases |
| 11:05-11:35 | Jürgen Wienands, University of Göttingen, Germany Intrinsic Control of Positive and Negative Signal Loops by the B Cell Antigen Receptor |
| 11:35-11:45 | Closing remarks |