研究業績

代表的文献

  1. Kano, M. & Kato, M. : Quisqualate receptors are specifically involved in cerebellar synaptic plasticity. Nature 325: 276-279, (1987). Pubmed
  2. Kano, M., Rexhausen, U., Dreessen, J., & Konnerth, A. : Synaptic excitation produces a long-lasting rebound potentiation of inhibitory synaptic signals in cerebellar Purkinje cells. Nature 356: 601-604, (1992).  Pubmed
  3. Aiba, A., Kano, M., Chen, C., Stanton, M.E., Fox, G.D., Herrup, K., Zwingman, T.A. & Tonegawa, S. : Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice. Cell 79: 377-388, (1994).  Pubmed
  4. Kano, M., Hashimoto, K., Chen, C., Abeliovich, A., Aiba, A., Kurihara, H., Watanabe, M., Inoue, Y. & Tonegawa, S.: Impaired synapse elimination during cerebellar development in PKC gamma mutant mice. Cell 83: 1223-1231, (1995).  Pubmed
  5. Chen, C., Kano, M., Chen, L., Bao, S., Kim, J.J., Hashimoto, K., Thompson, R.F. & Tonegawa, S.: Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKC gamma mutant mice. Cell 83: 1233-1242, (1995).  Pubmed
  6. Kano, M., Hashimoto, K., Kurihara, H., Watanabe, M., Inoue, Y., Aiba, A. & Tonegawa, S.: Persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking mGluR1. Neuron 18: 71-79, (1997). Pubmed
  7. Kano, M., Hashimoto, K., Watanabe, M., Kurihara, H., Inoue, Y., Offermanns, S., Jiangs, H., Wu, Y., Jun, K., Shin, H-S., Simon, M.I. & Wu, D. : PLCbeta 4 is specifically involved in climbing fiber synapse elimination in the developing cerebellum. Proc. Natl. Acad. Sci. USA. 95: 15724-15729, (1998).   Pubmed
  8. Ichise, T., Kano, M., Hashimoto, K., Yanagihara, D., Nakao, K., Shigemoto, R., Katsuki, M. & Aiba, A.: mGluR1 in cerebellar Purkinje cells essential for long-term depression, climbing fiber synapse elimination and motor coordination. Science 288: 1832-1835, (2000).  Pubmed
  9. Miyata, M., Finch, E.A., Khiroug. L., Hahimoto,K., Hayasaka, S., Oda, S., Inouye, M., Takagishi, Y., Augustine, G.J., & Kano, M. :Local calcium release in dendritic spines required for long-term synaptic depression. Neuron 28: 233-244, (2000).  Pubmed
  10. Ohno-Shosaku, T., Maejima, T. & Kano, M.: Endogenous cannabinoids mediate retrograde signals from depolarized postsynaptic neurons to presynaptic terminals. Neuron 29: 729-738, (2001).  Pubmed
  11. Maejima, T., Hashimoto, K., Yoshida, T., Aiba, A. & Kano, M.: Presynaptic inhibition caused by retrograde signal from metabotropic glutamate to cannabinoid receptors. Neuron 31: 463-475, (2001).  Pubmed
  12. Hashimoto, K. & Kano, M.: Functional differentiation of multiple climbing fiber inputs during synapse elimination in the developing cerebellum. Neuron 38: 785-796, (2003).  Pubmed
  13. Tabata, T., Araishi, K., Hashimoto, K., Hashimotodani, Y., van der Putten, H., Bettler, B. & Kano, M.: Ca2+ activity at GABAB receptors constitutively promotes metabotropic glutamate signaling in the absence of GABA. Proc. Natl. Acad. Sci. USA. 101: 16952-16957, (2004).  Pubmed
  14. Hashimotodani, Y., Ohno-Shosaku, T., Tsubokawa, H., Ogata, H., Emoto, K., Maejima, T., Araishi, K., Shin, H-S. & Kano, M.: Phospholipase Cbeta serves as a coincidence detector through its Ca2+ dependency for triggering endocannabinoid signal. Neuron 45: 257-268, (2005).  Pubmed
  15. Kakizawa, S., Miyazaki, T., Yanagihara, D., Iino, M., Watanabe, M. & Kano, M.: Maintenance of presynaptic function by AMPA receptor-mediated excitatory postsynaptic activity in adult brain. Proc. Natl. Acad. Sci. USA. 102: 19180-19185, (2005).  Pubmed
  16. Kitamura, K., Judkewitz, B., Kano, M., Denk, W. & Hausser, M.: Targeted patch-clamp recordings and single-cell electroporation of unlabeled neurons in vivo. Nat. Methods 5: 61-67 (2008).
  17. Kano M, Ohno-Shosaku T, Hashimotodani Y, Uchigashima M, Watanabe M: Endocannabinoid-mediated control of synaptic transmission. Physiol. Rev. 89: 309-380 (2009).  Pubmed
  18. Hashimoto, K., Ichikawa, R., Kitamura, K., Watanabe, M. & Kano, M.: Translocation of a "winner" climbing fiber to the Purkinje cell dendrite and subsequent elimination of "losers" from the soma in developing cerebellum. Neuron  63: 106-118, (2009).  Pubmed
  19. Tanimura A, Yamazaki, M, Hashimotodani Y, Uchigashima, M, Kawata S, Abe M, Kita Y, Hashimoto K, Shimizu T, Watanabe M, Sakimura K, Kano, M: The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase α mediates retrograde suppression of synaptic transmission. Neuron 65: 320-327, (2010).  Pubmed
  20. Hashimoto K, Tsujita M, Miyazaki T, Kitamura K, Yamazaki M, Shin H-S, Watanabe M, Sakimura K, Kano M: Postsynaptic P/Q-type Ca2+ channel in Purkinje cell mediates synaptic competition and elimination in developing cerebellum. Proc Natl Acad Sci USA 108: 9987-9992, (2011). Pubmed
  21. Nakayama H, Miyazaki T, Kitamura K, Hashimoto K, Yanagawa Y, Obata K, Sakimura K, Watanabe M & Kano M: GABAergic inhibition regulates developmental synapse elimination in the cerebellum. Neuron 74: 384-396 (2012).
  22. Tanimura A, Uchigashima M, Yamazaki M, Uesaka N, Mikuni T, Abe M, Hashimoto K, Watanabe M, Sakimura K & Kano M.: Synapse type-independent degradation of the endocannabinoid 2-arachidonoylglycerol after retrograde synaptic suppression. Proc Natl Acad Sci U S A. 109: 12195-121200 (2012).
  23. Takahashi N, Kitamura K, Matsuo N, Mayford M, Kano M, Matsuki N & Ikegaya Y: Locally synchronized synaptic inputs. Science 335: 353-356 (2012).
  24. Mikuni T, Uesaka N, Okuno H, Hirai H, Deisseroth K, Bito H & Kano M: Arc/Arg3.1 is a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum. Neuron 78: 1024-1035 (2013).
  25. Kawamura, Y., Nakayama, H., Hashimoto, K., Sakimura, K., Kitamura, K. & Kano, M.: Spike timing-dependent selective strengthening of single climbing fiber inputs to Purkinje cells during cerebellar development. Nature Commun. 4: 2732 (2013).
  26. Uesaka N, Uchigashima M, Mikuni T, Nakazawa T, Nakao H, Hirai H, Aiba A, Watanabe M & Kano M.: Retrograde Semaphorin Signaling Regulates Synapse Elimination in the Developing Mouse Brain.  Science 344: 1020-1023 (2014).
  27. Kawata S, Miyazaki T, Yamazaki M, Mikuni T, Yamasaki M, Hashimoto K, Watanabe M, Sakimura K & Kano M : Global Scaling Down of Excitatory Postsynaptic Responses in Cerebellar Purkinje Cells Impairs Developmental Synapse Elimination. Cell Rep. 8: 1-11 (2014).
  28. Nakazawa T, Hashimoto R, Sakoori K, Sugaya Y, Tanimura A, Hashimotodani Y, Ohi K, Yamamori H, Yasuda Y, Umeda-Yano S, Kiyama Y, Konno K, Inoue T, Yokoyama K, Inoue T, Numata S, Ohnuma T, Iwata N, Ozaki N, Hashimoto H, Watanabe W, Manabe T, Yamamoto T, Takeda M, Kano M: Emerging Roles of ARHGAP33 in Intracellular Trafficking of TrkB and Pathophysiology of Neuropsychiatric Disorders. Nat Commun 7:10594 (2016).
  29. Sugaya Y, Yamazaki M, Uchigashima M, Kobayashi K, Watanabe M, Sakimura K, Kano M:   Crucial roles of the endocannabinoid 2-arachidonoylglycerol in the suppression of epileptic seizures. Cell Rep 16: 1405-1415, 2016 (DOI: http://dx.doi.org/10.1016/j.celrep.2016.06.083) (Epub 2016 July 21)
  30. Narushima M, Uchigashima M, Yagasaki Y, Harada T, Nagumo Y, Uesaka N, Hashimoto K, Aiba A, Watanabe M, Miyata M, Kano M:   The metabotropic glutamate receptor subtype 1 mediates experience-dependent maintenance of mature synaptic connectivity in the visual thalamus. Neuron 91: 1097-1109, 2016 (DOI: 10.1016/j.neuron.2016.07.035)
  31. Choo M, Miyazaki T, Yamazaki M, Kawamura M, Nakazawa T, Zhang J, Tanimura A, Uesaka N, Watanabe M, Sakimura K, Kano M,:   Retrograde BDNF to TrkB signaling promotes synapse elimination in the developing cerebellum. Nat Commun 8: 195, 2017 (DOI: 10.1038/s41467-017-00260-w)
  32. Good J-M, Mahoney M, Miyazaki T, Tanaka KF, Sakimura K, Watanabe M, Kitamura K, Kano M:   Maturation of cerebellar Purkinje cell population activity during postnatal refinement of climbing fiber network. Cell Rep 21: 2066-2073, 2017  (DOI: http://dx.doi.org/10.1016/j.celrep.2017.10.101)
  33. Uesaka N, Abe M, Konno K, Yamazaki M, Sakoori K, Watanabe T, Kao TH, Mikuni T, Watanabe M, Sakimura K, Kano M: Retrograde Signaling from Progranulin to Sort1 Counteracts Synapse Elimination in the Developing Cerebellum. Neuron. 21;97(4):796-805. (Doi: 10.1016/j.neuron.2018.01.018.)
  34. Hashimotodani Y, Karube F, Yanagawa Y, Fujiyama F, Kano M. Supramammillary Nucleus Afferents to the Dentate Gyrus Co-release Glutamate and GABA and Potentiate Granule Cell Output. Cell Rep. 2018 Dec 4;25(10):2704-2715.e4. doi: 10.1016/j.celrep.2018.11.016. PubMed PMID: 30517859.
  35. Sacai H, Sakoori K, Konno K, Nagahama K, Suzuki H, Watanabe T, Watanabe M, Uesaka N, Kano M. Autism spectrum disorder-like behavior caused by reduced excitatory synaptic transmission in pyramidal neurons of mouse prefrontal cortex. Nat Commun. 2020 Oct 12;11(1):5140. doi: 10.1038/s41467-020-18861-3. PMID: 33046712; PMCID: PMC7552417.
  36. Nagahama K, Sakoori K, Watanabe T, Kishi Y, Kawaji K, Koebis M, Nakao K, Gotoh Y, Aiba A, Uesaka N, Kano M. Setd1a Insufficiency in Mice Attenuates Excitatory Synaptic Function and Recapitulates Schizophrenia-Related Behavioral Abnormalities. Cell Rep. 2020 Sep 15;32(11):108126. doi: 10.1016/j.celrep.2020.108126. PMID: 32937141.

Full Publications (since 1995)

<2021>

  1. Yamasaki M, Aiba A, Kano M, Watanabe M. mGluR1 signaling in cerebellar Purkinje cells: Subcellular organization and involvement in cerebellar function and disease. Neuropharmacology. 2021 Jun 4;194:108629. doi: 10.1016/j.neuropharm.2021.108629. Epub ahead of print. PMID: 34089728.
  2. Song B, Kang CY, Han JH, Kano M, Konnerth A, Bae S. In vivo genome editing in single mammalian brain neurons through CRISPR-Cas9 and cytosine base editors. Comput Struct Biotechnol J. 2021 Apr 25;19:2477-2485. doi: 10.1016/j.csbj.2021.04.051. PMID: 34025938; PMCID: PMC8113754.
  3. Nagahama K, Fujino S, Watanabe T, Uesaka N, Kano M. Combining electrophysiology and optogenetics for functional screening of pyramidal neurons in the mouse prefrontal cortex. STAR Protoc. 2021 Apr 15;2(2):100469. doi: 10.1016/j.xpro.2021.100469. PMID: 33937875; PMCID: PMC8079664.
  4. Nagao S, Hirai H, Kano M, Yuzaki M. Masao Ito-A Visionary Neuroscientist with a Passion for the Cerebellum. Neuroscience. 2021 May 10;462:1-3. doi: 10.1016/j.neuroscience.2021.02.028. PMID: 33892899.

<2020>

  1. Carrier-Ruiz A, Sugaya Y, Kumar D, Vergara P, Koyanagi I, Srinivasan S, Naoi T, Kano M, Sakaguchi M. Calcium imaging of adult-born neurons in freely moving mice. STAR Protoc. 2020 Dec 31;2(1):100238. doi: 10.1016/j.xpro.2020.100238. PMID: 33458703; PMCID: PMC7797924.
  2. Yamashiro K, Hori K, Lai ESK, Aoki R, Shimaoka K, Arimura N, Egusa SF, Sakamoto A, Abe M, Sakimura K, Watanabe T, Uesaka N, Kano M, Hoshino M. AUTS2 Governs Cerebellar Development, Purkinje Cell Maturation, Motor Function and Social Communication. iScience. 2020 Nov 18;23(12):101820. doi: 10.1016/j.isci.2020.101820. PMID: 33305180; PMCID: PMC7708818.
  3. Hoang H, Sato MA, Shinomoto S, Tsutsumi S, Hashizume M, Ishikawa T, Kano M, Ikegaya Y, Kitamura K, Kawato M, Toyama K. Improved hyperacuity estimation of spike timing from calcium imaging. Sci Rep. 2020 Oct 20;10(1):17844. doi: 10.1038/s41598-020-74672-y. PMID: 33082425; PMCID: PMC7576127.
  4. Sacai H, Sakoori K, Konno K, Nagahama K, Suzuki H, Watanabe T, Watanabe M, Uesaka N, Kano M. Autism spectrum disorder-like behavior caused by reduced excitatory synaptic transmission in pyramidal neurons of mouse prefrontal cortex. Nat Commun. 2020 Oct 12;11(1):5140. doi: 10.1038/s41467-020-18861-3. PMID: 33046712; PMCID: PMC7552417.
  5. Kuboyama K, Inoue T, Hashimotodani Y, Itoh T, Suzuki T, Tetsuzawa A, Ohtsuka Y, Kinoshita R, Takara R, Miyazawa T, Gusain P, Kano M, Yamada MK. Traceable stimulus-dependent rapid molecular changes in dendritic spines in the brain. Sci Rep. 2020 Sep 17;10(1):15266. doi: 10.1038/s41598-020-72248-4. PMID: 32943708; PMCID: PMC7499203.
  6. Nagahama K, Sakoori K, Watanabe T, Kishi Y, Kawaji K, Koebis M, Nakao K, Gotoh Y, Aiba A, Uesaka N, Kano M. Setd1a Insufficiency in Mice Attenuates Excitatory Synaptic Function and Recapitulates Schizophrenia-Related Behavioral Abnormalities. Cell Rep. 2020 Sep 15;32(11):108126. doi: 10.1016/j.celrep.2020.108126. PMID: 32937141.
  7. Nagai H, Yokoi T, Kano M, Tabata T. A test potential booster for fast-scan cyclic voltammetry with an electrophysiological amplifier. Anal Biochem. 2020 Dec 1;610:113934. doi: 10.1016/j.ab.2020.113934. Epub 2020 Sep 3. PMID: 32891595.
  8. Nagumo Y, Ueta Y, Nakayama H, Osaki H, Takeuchi Y, Uesaka N, Kano M, Miyata M. Tonic GABAergic Inhibition Is Essential for Nerve Injury-Induced Afferent Remodeling in the Somatosensory Thalamus and Ectopic Sensations. Cell Rep. 2020 Jun 23;31(12):107797. doi: 10.1016/j.celrep.2020.107797. PMID: 32579924.
  9. Suzuki T, Suzuki T, Raveau M, Miyake N, Sudo G, Tsurusaki Y, Watanabe T, Sugaya Y, Tatsukawa T, Mazaki E, Shimohata A, Kushima I, Aleksic B, Shiino T, Toyota T, Iwayama Y, Nakaoka K, Ohmori I, Sasaki A, Watanabe K, Hirose S, Kaneko S, Inoue Y, Yoshikawa T, Ozaki N, Kano M, Shimoji T, Matsumoto N, Yamakawa K. A recurrent PJA1 variant in trigonocephaly and neurodevelopmental disorders. Ann Clin Transl Neurol. 2020 Jul;7(7):1117-1131. doi: 10.1002/acn3.51093. Epub 2020 Jun 12. PMID: 32530565; PMCID: PMC7359110.
  10. Kumar D, Koyanagi I, Carrier-Ruiz A, Vergara P, Srinivasan S, Sugaya Y, Kasuya M, Yu TS, Vogt KE, Muratani M, Ohnishi T, Singh S, Teixeira CM, Chérasse Y, Naoi T, Wang SH, Nondhalee P, Osman BAH, Kaneko N, Sawamoto K, Kernie SG, Sakurai T, McHugh TJ, Kano M, Yanagisawa M, Sakaguchi M. Sparse Activity of Hippocampal Adult-Born Neurons during REM Sleep Is Necessary for Memory Consolidation. Neuron. 2020 Aug 5;107(3):552-565.e10. doi: 10.1016/j.neuron.2020.05.008. Epub 2020 Jun 4. PMID: 32502462.
  11. Rai Y, Watanabe T, Matsuyama K, Sakimura K, Uesaka N, Kano M. Phospholipase C β3 is Required for Climbing Fiber Synapse Elimination in Aldolase C-positive Compartments of the Developing Mouse Cerebellum. Neuroscience. 2021 May 10;462:36-43. doi: 10.1016/j.neuroscience.2020.04.035. Epub 2020 Apr 29. PMID: 32360594.
  12. Farkas E, Varga E, Kovács B, Szilvásy-Szabó A, Cote-Vélez A, Péterfi Z, Matziari M, Tóth M, Zelena D, Mezriczky Z, Kádár A, Kővári D, Watanabe M, Kano M, Mackie K, Rózsa B, Ruska Y, Tóth B, Máté Z, Erdélyi F, Szabó G, Gereben B, Lechan RM, Charli JL, Joseph-Bravo P, Fekete C. A Glial-Neuronal Circuit in the Median Eminence Regulates Thyrotropin-Releasing Hormone-Release via the Endocannabinoid System. iScience. 2020 Mar 27;23(3):100921. doi: 10.1016/j.isci.2020.100921. Epub 2020 Feb 17. PMID: 32143135; PMCID: PMC7058404.
  13. Saito R, Koebis M, Nagai T, Shimizu K, Liao J, Wulaer B, Sugaya Y, Nagahama K, Uesaka N, Kushima I, Mori D, Maruyama K, Nakao K, Kurihara H, Yamada K, Kano M, Fukada Y, Ozaki N, Aiba A. Comprehensive analysis of a novel mouse model of the 22q11.2 deletion syndrome: a model with the most common 3.0-Mb deletion at the human 22q11.2 locus. Transl Psychiatry. 2020 Feb 5;10(1):35. doi: 10.1038/s41398-020-0723-z. PMID: 32066675; PMCID: PMC7026107.
  14. Sakairi H, Kamikubo Y, Abe M, Ikeda K, Ichiki A, Tabata T, Kano M, Sakurai T. G Protein-Coupled Glutamate and GABA Receptors Form Complexes and Mutually Modulate Their Signals. ACS Chem Neurosci. 2020 Feb 19;11(4):567-578. doi: 10.1021/acschemneuro.9b00599. Epub 2020 Feb 5. PMID: 31977183.

<2019>

  1. Watanabe T, Suzuki H, Kano M. [Postnatal Development of Cerebellar Neural Circuits]. Brain Nerve. 2019 Dec;71(12):1373-1383. Japanese. doi: 10.11477/mf.1416201457. PMID: 31787626.
  2. Tanigami H, Yoneda M, Tabata Y, Echigo R, Kikuchi Y, Yamazaki M, Kishimoto Y, Sakimura K, Kano M, Ohno-Shosaku T. Endocannabinoid Signaling from 2-Arachidonoylglycerol to CB1 Cannabinoid Receptor Facilitates Reward-based Learning of Motor Sequence. Neuroscience. 2019 Nov 21;421:1-16. doi: 10.1016/j.neuroscience.2019.09.040. Epub 2019 Nov 1. PMID: 31682822.
  3. Tsutsumi S, Hidaka N, Isomura Y, Matsuzaki M, Sakimura K, Kano M, Kitamura K. Modular organization of cerebellar climbing fiber inputs during goal-directed behavior. Elife. 2019 Oct 9;8:e47021. doi: 10.7554/eLife.47021. PMID: 31596238; PMCID: PMC6844646.
  4. Kano M, Watanabe T. Developmental synapse remodeling in the cerebellum and visual thalamus. F1000Res. 2019 Jul 25;8. pii: F1000 Faculty Rev-1191. doi: 10.12688/f1000research.18903.1. eCollection 2019. Review. PubMed PMID: 31372212; PubMed Central PMCID: PMC6662676.
  5. Martínez-Torres S, Cutando L, Pastor A, Kato A, Sakimura K, de la Torre R, Valjent E, Maldonado R, Kano M, Ozaita A. Monoacylglycerol lipase blockade impairs fine motor coordination and triggers cerebellar neuroinflammation through cyclooxygenase-2. Brain Behav Immun. 2019 Jun 25. pii: S0889-1591(19)30344-7.doi: 10.1016/j.bbi.2019.06.036. [Epub ahead of print] PubMed PMID: 31251974.
  6. Inoue M, Takeuchi A, Manita S, Horigane SI, Sakamoto M, Kawakami R, Yamaguchi K, Otomo K, Yokoyama H, Kim R, Yokoyama T, Takemoto-Kimura S, Abe M, Okamura M,Kondo Y, Quirin S, Ramakrishnan C, Imamura T, Sakimura K, Nemoto T, Kano M, Fujii H, Deisseroth K, Kitamura K, Bito H. Rational Engineering of XCaMPs, a Multicolor GECI Suite for In Vivo Imaging of Complex Brain Circuit Dynamics. Cell. 2019 May 16;177(5):1346-1360.e24. doi: 10.1016/j.cell.2019.04.007. Epub 2019 May 9. PubMed PMID: 31080068.
  7. Nakao H, Kishimoto Y, Hashimoto K, Kitamura K, Yamasaki M, Nakao K, Watanabe M, Kano M, Kirino Y, Aiba A. mGluR1 in cerebellar Purkinje cells is essential for the formation but not expression of associative eyeblink memory. Sci Rep. 2019 May 14;9(1):7353. doi: 10.1038/s41598-019-43744-z. PubMed PMID: 31089195; PubMed Central PMCID: PMC6517439.
  8. Sakai Y, Kassai H, Nakayama H, Fukaya M, Maeda T, Nakao K, Hashimoto K,Sakagami H, Kano M, Aiba A. Hyperactivation of mTORC1 disrupts cellular homeostasis in cerebellar Purkinje cells. Sci Rep. 2019 Feb 26;9(1):2799. doi: 10.1038/s41598-019-38730-4. PubMed PMID: 30808980; PubMed Central PMCID:PMC6391425.

<2018>

  1. Yoshida K, Kita Y, Tokuoka SM, Hamano F, Yamazaki M, Sakimura K, Kano M, Shimizu T. Monoacylglycerol lipase deficiency affects diet-induced obesity, fat absorption, and feeding behavior in CB(1) cannabinoid receptor-deficient mice.
  2. FASEB J. 2019 Feb;33(2):2484-2497. doi: 10.1096/fj.201801203R. Epub 2018 Sep 28. PubMed PMID: 30265576.
  3. Hashimotodani Y, Karube F, Yanagawa Y, Fujiyama F, Kano M. Supramammillary Nucleus Afferents to the Dentate Gyrus Co-release Glutamate and GABA and Potentiate Granule Cell Output. Cell Rep. 2018 Dec 4;25(10):2704-2715.e4. doi: 10.1016/j.celrep.2018.11.016. PubMed PMID: 30517859.
  4. Kano M, Watanabe T, Uesaka N, Watanabe M. Multiple Phases of Climbing Fiber Synapse Elimination in the Developing Cerebellum. Cerebellum. 2018 Dec;17(6):722-734. doi: 10.1007/s12311-018-0964-z. Review. PubMed PMID: 30009357.
  5. Kikuchihara S, Sugio S, Tanaka KF, Watanabe T, Kano M, Yamazaki Y, Watanabe M, Ikenaka K. Ectopic positioning of Bergmann glia and impaired cerebellar wiring in Mlc1-over-expressing mice. J Neurochem. 2018 Nov;147(3):344-360. doi: 10.1111/jnc.14486. Epub 2018 Aug 8. PubMed PMID: 29920672.
  6. Sugaya Y, Kano M. Control of excessive neural circuit excitability and prevention of epileptic seizures by endocannabinoid signaling. Cell Mol Life Sci. 2018 Aug;75(15):2793-2811. doi: 10.1007/s00018-018-2834-8. Epub 2018 May 8. Review. PubMed PMID: 29737364.
  7. Uesaka N, Kano M. Presynaptic Mechanisms Mediating Retrograde Semaphorin Signals for Climbing Fiber Synapse Elimination During Postnatal Cerebellar Development. Cerebellum. 2018 Feb;17(1):17-22. doi: 10.1007/s12311-017-0888-z. Review. PubMed PMID: 28965326.
  8. Hirai H, Kano M: Type 1 metabotropic glutamate receptor and its signaling molecules as therapeutic targets for the treatment of cerebellar disorders. Curr Opin Pharmacol. 2018 Mar 8;38:51-58. (Doi: 10.1016/j.coph.2018.02.002.)
  9. Chen S, Weitemier AZ, Zeng X, He L, Wang X, Tao Y, Huang AJY, Hashimotodani Y, Kano M, Iwasaki H, Parajuli LK, Okabe S, Teh DBL, All AH, Tsutsui-Kimura I, Tanaka KF, Liu X, McHugh TJ: Near-infrared deep brain stimulation via upconversion nanoparticle-mediated optogenetics. Science. 2018; 359(6376):679-684. (Doi: 10.1126/science.aaq1144.)
  10. Uesaka N, Abe M, Konno K, Yamazaki M, Sakoori K, Watanabe T, Kao TH, Mikuni T, Watanabe M, Sakimura K, Kano M: Retrograde Signaling from Progranulin to Sort1 Counteracts Synapse Elimination in the Developing Cerebellum. Neuron. 21;97(4):796-805. (Doi: 10.1016/j.neuron.2018.01.018.)
  11. Yokoyama R, Kinoshita K, Hata Y, Abe M, Matsuoka K, Hirono K, Kano M, Nakazawa M, Ichida F, Nishida N, Tabata T: A mutant HCN4 channel in a family with bradycardia, left bundle branch block, and left ventricular noncompaction. Heart Vessels. 2018 Jan 18. doi: 10.1007/s00380-018-1116-6.

<2017>

  1. Nakai N, Nagano M, Saitow F, Watanabe Y, Kawamura Y, Kawamoto A, Tamada K, Mizuma H, Onoe H, Watanabe Y, Monai H, Hirase H, Nakatani J, Inagaki H, Kawada T, Miyazaki T, Watanabe M, Sato Y, Okabe S, Kitamura K, Kano M, Hashimoto K, Suzuki H, Takumi T: Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV mice. Sci Adv 3: e1603001, 2017 (doi: 10.1126/sciadv.1603001), eCollection 2017 Jun
  2. Miyazaki T, Yamasaki M, Hashimoto K, Kohda K, Yuzaki M, Shimamoto K, Tanaka K, Kano M, Watanabe M: Glutamate transporter GLAST controls synaptic wrapping by Bergmann glia and ensures proper wiring of Purkinje cells. Proc Natl Acad Sci USA 114:7438-7443, 2017 (doi: 10.1073/pnas.1617330114)
  3. Watase K, Aikawa T, Watanabe T, Miyazaki T, Mikuni T, Mogushi K, Tanaka H, Wakamori M, Tewari A, Khodakhahh K, Sakurai M, Aizawa H, Watanebe M, Kano M, Mizusawa H: Alternative splicing in the C-terminal tail of CaV2.1 is essential for preventing a neurological disease in mice. Hum Mol Genet 26: 3094-3104, 2017 (doi: 10.1093/hmg/ddx193)
  4. Choo M, Miyazaki T, Yamazaki M, Kawamura M, Nakazawa T, Zhang J, Tanimura A, Uesaka N, Watanabe M, Sakimura K, Kano M,: Retrograde BDNF to TrkB signaling promotes synapse elimination in the developing cerebellum. Nat Commun 8: 195, 2017 (DOI: 10.1038/s41467-017-00260-w)
  5. Good J-M, Mahoney M, Miyazaki T, Tanaka KF, Sakimura K, Watanabe M, Kitamura K, Kano M: Maturation of cerebellar Purkinje cell population activity during postnatal refinement of climbing fiber network. Cell Rep 21: 2066-2073, 2017 (DOI: http://dx.doi.org/10.1016/j.celrep.2017.10.101)
  6. Kano M, Watanabe T: Type-1 metabotropic glutamate receptor signaling in cerebellar Purkinje cells in health and disease. F1000Research 6 (F1000 Faculty Rev):416, 2017 (doi: 10.12688/f1000research.10485.1)
  7. Uesaka N, Kano M: Presynaptic mechanisms mediating retrograde semaphorin signals for climbing fiber synapse elimination during postnatal cerebellar development. Cerebellum 2017 Sep 30. (doi: 10.1007/s12311-017-0888-z)

<2016>

  1. Nakazawa T, Hashimoto R, Sakoori K, Sugaya Y, Tanimura A, Hashimotodani Y, Ohi K, Yamamori H, Yasuda Y, Umeda-Yano S, Kiyama Y, Konno K, Inoue T, Yokoyama K, Inoue T, Numata S, Ohnuma T, Iwata N, Ozaki N, Hashimoto H, Watanabe W, Manabe T, Yamamoto T, Takeda M, Kano M: Emerging Roles of ARHGAP33 in Intracellular Trafficking of TrkB and Pathophysiology of Neuropsychiatric Disorders. Nat Commun 7:10594 (2016).
  2. Ly R, Bouvier G, Szapiro G, Prosser H, Randall AD, Kano M, Sakimura K, Isope P, Barbour BJ, Feltz A: Contribution of postsynaptic T-type calcium channels to parallel fibre-Purkinje cell synaptic responses. J Physiol (Lond) 594: 915-936 (2016).
  3. Ichikawa R, Hashimoto K, Miyazaki T, Uchigashima M, Yamasaki M, Aiba A, Kano M, Watanabe M: Territories of heterologous inputs onto Purkinje cell dendrites are segregated by mGluR1-dependent parallel fiber synapse elimination. Proc Natl Acad Sci USA 113: 2282-2287 (2016).
  4. Kinoshita K, Takahashi H, Hata Y, Nishide K, Kato M, Fujita H, Yoshida S, Murai K, Mizumaki K, Nishida K, Yamaguchi Y, Kano M, Tabata T, Nishida N: SCN5A(K817E), a novel Brugada syndrome-associated mutation that alters the activation gating of NaV1.5 channel. Heart Rhythm 13:1113-1120, 2016 May; (doi: 10.1016/j.hrthm.2016.01.008) (Epub 2016 Jan 8)
  5. Matsuda K, Budisantoso T, Mitakidis N, Sugaya Y, Miura E, Kakegawa W, Yamasaki M, Konno K, Uchigashima M, Abe M, Watanabe I, Kano M, Watanabe M, Sakimura K, Radu Aricescu A, Yuzaki M: Presynaptic C1ql2/3 dictates postsynaptic kainate receptor localization in the hippocampus. Neuron 90:752-767, 2016 (DOI: 10.1016/j.neuron.2016.04.001)
  6. Matsumoto-Makidono Y, Nakayama1 H, Yamasaki M, Miyazaki T, Kobayashi K, Watanabe M, Kano M, Sakimura K, Hashimoto K: Ionic basis for membrane potential resonance in neurons of the inferior olive. Cell Rep 16: 994-1004, 2016 (DOI: http://dx.doi.org/10.1016/j.celrep.2016.06.053)
  7. Sugaya Y, Yamazaki M, Uchigashima M, Kobayashi K, Watanabe M, Sakimura K, Kano M: Crucial roles of the endocannabinoid 2-arachidonoylglycerol in the suppression of epileptic seizures. Cell Rep 16: 1405-1415, 2016 (DOI: http://dx.doi.org/10.1016/j.celrep.2016.06.083)
  8. Narushima M, Uchigashima M, Yagasaki Y, Harada T, Nagumo Y, Uesaka N, Hashimoto K, Aiba A, Watanabe M, Miyata M, Kano M: The metabotropic glutamate receptor subtype 1 mediates experience-dependent maintenance of mature synaptic connectivity in the visual thalamus. Neuron 91: 1097-1109, 2016 (DOI: 10.1016/j.neuron.2016.07.035)
  9. Dhar M, Brenner JM, Sakimura K, Kano M, Nishiyama H: Spatiotemporal dynamics of lesion-induced axonal sprouting and its relation to functional architecture of the cerebellum. Nat Commun 7: 12938, 2016 (DOI: 10.1038/ncomms12938)
  10. Binda F, Dorgans K, Reibel S, Sakimura K, Kano M, Poulain B, Isope P: Inhibition promotes long-term potentiation at cerebellar excitatory synapses. Sci Rep 6: 33561, 2016 (doi:10.1038/srep33561)
  11. Piochon C, Kano M, Hansel C: LTD-like molecular pathways in developmental synaptic pruning. Nat Neurosci 19: 1299-1310, 2016 (doi:10.1038/nn.4389)
  12. Jung D, Hwang YJ, Ryu H, Kano M, Sakimura K, Cho J: Conditional knockout of Cav2.1 disrupts the accuracy of spatial recognition of CA1 place cells and spatial/contextual recognition behavior. Front. Behav. Neurosci 10: Article 214, 2016 (doi.org/10.3389/fnbeh.2016.00214)
  13. Leto K, Arancillo M, Becker EB, Buffo A, Chiang C, Ding B, Dobyns WB, Dusart I, Haldipur P, Hatten ME, Hoshino M, Joyner AL, Kano M, Kilpatrick DL, Koibuchi N, Marino S, Martinez S, Millen KJ, Millner TO, Miyata T, Parmigiani E, Schilling K, Sekerková G, Sillitoe RV, Sotelo C, Uesaka N, Wefers A, Wingate RJ, Hawkes R: Consensus Paper: Cerebellar Development. Cerebellum 15: 789-828, 2016 (DOI: 10.1007/s12311-015-0724-2)

<2015>

  1. Soltesz I, Alger BE, Kano M, Lee S-H, Lovinger DM, Ohno-Shosaku T, Watanabe M: Weeding out bad waves: Towards selective cannabinoid circuit control in epilepsy. Nat Rev Neurosci 16: 264-277 (2015).
  2. Kishimoto Y, Cagniard B, Yamazaki M, Nakayama J, Sakimura K, Kirino Y, Kano M: Task-specific enhancement of hippocampus-dependent learning in mice deficient in monoacylglycerol lipase, the major hydrolyzing enzyme of the endocannabinoid 2-arachidonoylglycerol. Front Behav Neurosci 9: Article 134 (2015).
  3. Kishimoto Y, Yamamoto S, Suzuki K, Toyoda H, Kano M, Tsukada H, Kirino Y: Implicit memory in monkeys: Development of a delay eyeblink conditioning system with parallel electromyographic and high-speed video measurements. PLoS ONE 10: e0129828 (2015).
  4. Kita Y, Yoshida K, Tokuoka SM, Hamano F, Yamazaki M, Sakimura K, Kano M, Shimizu T: Fever is Mediated by Conversion of Endocannabinoid 2-Arachidonoylglycerol to Prostaglandin E2. PLoS ONE 10: e0133663, (2015).
  5. Aida T, Yoshida J, Nomura M, Tanimura A, Iino Y, Soma M, Bai N, Ito Y, Cui W, Aizawa H, Yanagisawa M, Nagai T, Takata N, Tanaka KF, Takayanagi R, Kano M, Götz M, Hirase H & Tanaka K: Astroglial Glutamate Transporter Deficiency Increases Synaptic Excitability and Leads to Pathological Repetitive Behaviors in Mice. Neuropsychopharmacology. 9. (2015).
  6. Tsutsumi S, Yamazaki M, Miyazaki T, Watanabe M, Sakimura K, Kano M & Kitamura K: Structure-function relationships between aldolase C/zebrin II expression and complex spike synchrony in the cerebellum. J Neurosci 35: 843-852 (2015).
  7. Inoue M, Takeuchi A, Horigane S, Ohkura M, Gengyo-Ando K, Fujii H, Kamijo S, Takemoto-Kimura S, Kano M, Nakai J, Kitamura K & Bito H: Rational design of a high-affinity, fast, red calcium indicator R-CaMP2. Nat Methods 12:64-70 (2015).
  8. Uesaka N, Uchigashima M, Mikuni T, Hirai H, Watanabe M & Kano M: Retrograde signaling for climbing fiber synapse elimination. Cerebellum. 14: 4-7 (2015).

<2014>

  1. Piochon C, Kloth AD, Grasselli G, Titley HK, Nakayama H, Hashimoto K, Wan V, Simmons DH, Eissa T, Nakatani J, Cherskov A, Miyazaki T, Watanabe M, Takumi T, Kano M, Wang SS & Hansel C: Cerebellar plasticity and motor learning deficits in a copy-number variation mouse model of autism. Nat Commun. 5:5586 (2014).
  2. Otsu Y, Marcaggi P, Feltz A, Isope P, Kollo M, Nusser Z, Mathieu B, Kano M, Tsujita M, Sakimura K & Dieudonné S: Activity-dependent gating of calcium spikes by A-type K+ channels controls climbing fiber signaling in Purkinje cell dendrites. Neuron 84:137-51 (2014).
  3. Kano M: Control of synaptic function by endocannabinoid-mediated retrograde signaling. Proc Japan Acad Ser B 90: 235-250 (2014).
  4. Kawata S, Miyazaki T, Yamazaki M, Mikuni T, Yamasaki M, Hashimoto K, Watanabe M, Sakimura K & Kano M : Global Scaling Down of Excitatory Postsynaptic Responses in Cerebellar Purkinje Cells Impairs Developmental Synapse Elimination. Cell Rep. 8: 1-11 (2014).
  5. Petrenko A B, Yamazaki M, Sakimura K, Kano M, Baba H4: Augmented tonic pain-related behavior in knockout mice lacking monoacylglycerol lipase, a major degrading enzyme for the endocannabinoid 2-arachidonoylglycerol. Behav. Brain Res. 271, 51-58 (2014).
  6. Uesaka N, Uchigashima M, Mikuni T, Nakazawa T, Nakao H, Hirai H, Aiba A, Watanabe M & Kano M.: Retrograde Semaphorin Signaling Regulates Synapse Elimination in the Developing Mouse Brain. Science 344: 1020-1023 (2014).
  7. Ohno-Shosaku T, Kano M: Endocannabinoid-mediated retrograde modulation of synaptic transmission. Curr Opin Neurobiol, 29, 1-8 (2014).
  8. Tada, M., Takeuchi, A., Hashizume, M., Kitamura, K. & Kano, M.: A highly sensitive fluorescent indicator dye for calcium imaging of neural activity in vitro and in vivo. Eur. J. Neurosci., 39: 1720 - 1728 (2014).
  9. Kassai H, Sugaya Y, Noda S, Nakao K, Maeda T, Kano M, Aiba A: Selective activation of mTORC1 signaling recapitulates microcephaly, tuberous sclerosis and neurodegenerative diseases. Cell Rep. 7, 1626-1639 (2014).
  10. Ohtani Y, Miyata M, Hashimoto K, Tabata T, Kishimoto K, Fukaya M, Kase D, Kassai H, Nakao K, Hirata T, Watanabe M, Kano M, Aiba A: The synaptic targeting of mGluR1 by its carboxyl-terminal domain is crucial for cerebellar function. J Neurosci 34: 2702-2712 (2014).
  11. Horváth E, Woodhams SG, Nyilas R, Henstridge CM, Kano M, Sakimura K, Watanabe M, Katona I: Heterogeneous presynaptic distribution of monoacylglycerol lipase, a multipotent regulator of nociceptive circuits in the mouse spinal cord. Eur J Neurosci 39: 419-434 (2014).

<2013>

  1. Kano M, Watanabe M: Cerebellar Circuits. In: RUBENSTEIN J. L. R. and RAKIC P. (ed.) Comprehensive Developmental Neuroscience: Neural Circuit Development and Function in the Brain, volume 3, pp. 75-93 Amsterdam: Elsevier (2013).
  2. Kamikubo, Y., Shimomura, T., Fujita, Y., Tabata, T., Kashiyama, T., Sakurai, T., Fukurotani, K. & Kano, M.: Functional cooperation of metabotropic adenosine and glutamate receptors regulates postsynaptic plasticity in the cerebellum. J. Neurosci. 33: 18661-18671 (2013).
  3. Kawamura, Y., Nakayama, H., Hashimoto, K., Sakimura, K., Kitamura, K. & Kano, M.: Spike timing-dependent selective strengthening of single climbing fiber inputs to Purkinje cells during cerebellar development. Nature Commun. 4: 2732 (2013).
  4. Kitamura, K. & Kano, M.: Dendritic calcium signaling in cerebellar Purkinje cell. Neural Networks 47: 11-17 (2013).
  5. Hashizume, M., Miyazaki, T., Sakimura, K., Watanabe, M., Kitamura, K. & Kano, M.: Disruption of cerebellar microzonal organization in GluD2 (GluRδ2) knockout mouse. Front. Neural Circuits 7: 130 (2013).
  6. Hashimotodani Y, Ohno-Shosaku T, Tanimura A, Kita Y, Sano Y, Shimizu T, Di Marzo V, Kano M: Acute inhibition of diacylglycerol lipase blocks endocannabinoid-mediated retrograde synaptic suppression: evidence for on-demand biosynthesis of 2-arachidonoylglycerol. J Physiol (Lond) 591:4765-4776 (2013).
  7. Hashimoto K & Kano M.: Synapse elimination in the developing cerebellum. Cell Mol. Life Sci. 24: 4667-4680 (2013).
  8. Kawashima T, Kitamura K, Suzuki K, Nonaka M, Kamijo S, Takemoto-Kimura S, Kano M, Okuno H, Ohki K, Bito H: Functional labeling of neurons and their projections using a synthetic activity-dependent promoter E-SARE. Nat. Meth. 10: 889-895 (2013).
  9. Keimpema, E, Alpar A, Howell F, Malenczyk K, Hobbs C, Hurd Y.L, Watanabe M, Sakimura K, Kano M, Doherty P & Harkany T: Diacylglycerol lipase α manipulation reveals developmental roles for intercellular endocannabinoid signaling. Sci. Rep. 3: 2093 (2013).
  10. Mikuni T, Uesaka N, Okuno H, Hirai H, Deisseroth K, Bito H & Kano M: Arc/Arg3.1 is a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum. Neuron 78: 1024-1035 (2013).
  11. Hoshina N, Tanimura A, Yamasaki M, Inoue T, Fukabori R, Kuroda T, Yokoyama K, Tezuka T, Sagara H, Hirano S, Kiyonari H, Takada M, Kobayashi K, Watanabe M, Kano M, Nakazawa T & Yamamoto T: Protocadherin 17 regulates presynaptic assembly in topographic cortico-basal ganglia circuits. Neuron 78: 839-854 (2013).
  12. Fujii H, Inoue M, Okuno H, Sano Y, Takemoto-Kimura S, Kitamura K, Kano M & Bito H: Nonlinear decoding and asymmetric representation of neuronal input information by CaMKIIα and calcineurin. Cell Rep. 3: 978-987 (2013).
  13. Sugaya Y, Cagniard B, Yamazaki M, Sakimura K & Kano M.: The endocannabinoid 2-arachidonoylglycerol negatively regulates habituation by suppressing excitatory recurrent network activity and reducing long-term potentiation in the dentate gyrus. J. Neurosci. 33: 3588-3601 (2013).
  14. Hira R, Ohkubo F, Ozawa K, Isomura Y, Kitamura K, Kano M, Kasai H & Matsuzaki M: Spatiotemporal dynamics of functional clusters of neurons in the mouse motor cortex during a voluntary movement. J. Neurosci. 33: 1377-1390 (2013).
  15. Kano M, Nakayama H, Hashimoto K, Kitamura K, Sakimura K, Watanabe M: Calcium-dependent regulation of climbing fiber synapse elimination during postnatal cerebellar development. J. Physiol. (Lond) 591, 3151-3158 (2013).

<2012>

  1. Kano M, Watanabe M: Synaptogenesis and Synaptic elimination. In: Handbook of Cerebellum and Cerebellar Disorders, Mario Manto, Donna Gruol, Jeremy Schmahmann, Nori Koibuchi, Ferdinando Rossi, (eds), Springer, 281-299 (2012).
  2. Uesaka N, Mikuni T, Hashimoto K, Hirai H, Sakimura K, & Kano M: Organotypic Coculture Preparation for the Study of Developmental Synapse Elimination in Mammalian Brain. J. Neurosci. 32: 11657-11670 (2012).
  3. Tanimura A, Uchigashima M, Yamazaki M, Uesaka N, Mikuni T, Abe M, Hashimoto K, Watanabe M, Sakimura K & Kano M.: Synapse type-independent degradation of the endocannabinoid 2-arachidonoylglycerol after retrograde synaptic suppression. Proc Natl Acad Sci U S A. 109: 12195-121200 (2012).
  4. Nakayama H, Miyazaki T, Kitamura K, Hashimoto K, Yanagawa Y, Obata K, Sakimura K, Watanabe M & Kano M: GABAergic inhibition regulates developmental synapse elimination in the cerebellum. Neuron 74: 384-396 (2012).
  5. Ohi K, Hashimoto R, Nakazawa T, Okada T, Yasuda Y, Yamamori H, Fukumoto M, Umeda-Yano S, Iwase M, Kazui H, Yamamoto T, Kano M, Takeda M: The p250GAP gene is associated with risk for schizophrenia and schizotypal personality traits. PLoS One 7: e35696 (2012).
  6. Miyazaki T, Yamasaki M, Hashimoto K, Yamazaki M, Abe M, Usui H, Kano M, Sakimura K, Watanabe M: Cav2.1 in cerebellar Purkinje cells regulates competitive excitatory synaptic wiring, cell survival, and cerebellar biochemical compartmentalization. J. Neurosci. 32: 1311-28 (2012).
  7. Takahashi N, Kitamura K, Matsuo N, Mayford M, Kano M, Matsuki N & Ikegaya Y: Locally synchronized synaptic inputs. Science 335: 353-356 (2012).
  8. Ohno-Shosaku T, Tanimura A, Hashimotodani Y, Kano M: Endocannabinoids and retrograde modulation of synaptic transmission. Neuroscientist 18:119-32 (2012).

<2011>

  1. Kano M, Hashimoto K: Activity-Dependent Maturation of Climbing Fiber to Purkinje Cell Synapses during Postnatal Cerebellar Development. Cerebellum 11: 449-50 (2011).
  2. Watanabe M & Kano M: Climbing fiber synapse elimination in cerebellar Purkinje cells. Eur. J. Neurosci. 34: 1697-1710 (2011).
  3. Ichikawa R, Yamasaki M, Miyazaki T, Konno K, Hashimoto K, Tatsumi H, Inoue Y, Kano M & Watanabe M: Developmental Switching of Perisomatic Innervation from Climbing Fibers to Basket Cell Fibers in Cerebellar Purkinje Cells. J. Neurosci. 31: 16916 -16927 (2011).
  4. Kitamura K & Häusser M: Dendritic Calcium Signaling Triggered by Spontaneous and Sensory-Evoked Climbing Fiber Input to Cerebellar Purkinje Cells In Vivo. J. Neurosci. 31: 10847-10858 (2011).
  5. Hashimoto K, Tsujita M, Miyazaki T, Kitamura K, Yamazaki M, Shin H-S, Watanabe M, Sakimura K, Kano M: Postsynaptic P/Q-type Ca2+ channel in Purkinje cell mediates synaptic competition and elimination in developing cerebellum. Proc Natl Acad Sci USA 108: 9987-9992, (2011).
  6. Uchigashima M, Yamazaki M, Yamasaki M, Tanimura A, Sakimura K, Kano M, Watanabe M: Molecular and morphological configuration for 2-arachidonoylglycerol-mediated retrograde signaling at mossy cell-granule cell synapses in the dentate gyrus. J. Neurosci. 31: 7700-7714 (2011).
  7. Noguchi J, Nagaoka A, Watanabe S, Ellis-Davies GC, Kitamura K, Kano M, Matsuzaki M, Kasai H: In vivo two-photon uncaging of glutamate revealing the structure-function relationships of dendritic spines in the neocortex of adult mice. J. Physiol. 589: 2447-2457 (2011).
  8. Ludányi A, Sherry Shu-Jung Hu, S, Yamazaki M, Tanimura A, Piomelli D, Watanabe M, Kano M, Sakimura K, Maglóczky Z, Mackie K, Freund TF, Katona I: Complementary synaptic distribution of enzymes responsible for synthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in the human hippocampus. Neuroscience 174: 50-63 (2011).
  9. Miyata M, Kishimoto Y, Tanaka M, Hashimoto K, Hirashima N, Murata Y, Kano M, Takagishi Y: A role for myosin Va in cerebellar plasticity and motor learning: a possible mechanism underlying neurological disorder in myosin Va disease. J. Neurosci. 31: 6067-6078 (2011).
  10. Hashimotodani Y, Ohno-Shosaku T, Yamazaki M, Sakimura K, Kano M: Neuronal protease-activated receptor 1 drives synaptic retrograde signaling mediated by the endocannabinoid 2-arachidonoylglycerol. J. Neurosci. 31: 3104-3109 (2011)
  11. Yoshida T, Uchigashima M, Yamasaki M, Katona I, Yamazaki M, Sakimura K, Kano M, Yoshioka M, Watanabe M: Unique inhibitory synapse with particularly rich endocannabinoid signaling machinery on pyramidal neurons in basal amygdaloid nucleus. Proc Natl Acad Sci USA 108: 3059-3064 (2011).

<2010>

  1. Yamada A, Uesaka N, Hayano Y, Tabata T, Kano M, Yamamoto N: Role of pre- and postsynaptic activity in thalamocortical axon branching. Proc Natl Acad Sci USA 107: 7562-7567 (2010).
  2. Tanimura A, Yamazaki, M, Hashimotodani Y, Uchigashima, M, Kawata S, Abe M, Kita Y, Hashimoto K, Shimizu T, Watanabe M, Sakimura K, Kano, M: The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase α mediates retrograde suppression of synaptic transmission. Neuron 65: 320-327, (2010).
  3. Fujita Y, Shimomura T, Hosoguchi M, Kano M, Fukurotani K, Tabata T: A new multiple-drug applicator with minimal drug cross-talk, leakage, and consumption. Neurosci Res, 66: 412-414 (2010).
  4. Yamazaki M, Fukaya M, Hashimoto K, Yamasaki M, Tsujita M, Itakura M, Abe M, Natsume R, Takahashi M, Kano M, Sakimura K, Watanabe M: TARPs γ-2 and γ-7 are essential for AMPA receptor expression in the cerebellum. Eur J Neurosci, 31: 2204-2220 (2010).
  5. Tabata T, Kano M: GABAB receptor-mediated modulation of metabotropic glutamate signaling and synaptic plasticity in central neurons. In: GABAB Receptor Pharmacology: A Tribute to Norman Bowery (Advances in Pharmacology (Vol. 58) , Thomas P. Blackburn and S. J. Enna, (eds), Academic Press, 149-173 (2010).

<2009>

  1. Takeda S, Sato N, Takeuchi D, Kurinami H, Shinohara M, Niisato K, Kano M, Ogihara T, Rakugi H, Morishita R: Angiotensin receptor blocker, olmesartan, improved cerebrovascular dysfunction and prevented cognitive decline in early-stage Alzheimer disease model mouse. Hypertension, 54:1345-1352, (2009).
  2. Taniguchi S, Nakazawa T, Tanimura A, Kiyama Y, Tezuka T, Watabe AM, Katayama N, Yokoyama K, Inoue T, Izumi-Nakaseko H, Kakuta S, Sudo K, Iwakura Y, Umemori H, Inoue T, Murphy NP, Hashimoto K, Kano M, Manabe T, Yamamoto T: Involvement of NMDAR2A tyrosine phosphorylation in depression-related behavior. EMBO J, 28: 3717-3129, (2009).
  3. Takeda S, Sato N, Niisato K, Takeuchi D, Kurinami H, Shinohara M, Rakugi H, Kano M, Morishita R: Validation of Aβ1-40 administration into mouse cerebroventricles as an animal model for Alzheimer disease. Brain Res., 1280: 137-147, (2009).
  4. Hashimoto, K., Ichikawa, R., Kitamura, K., Watanabe, M. & Kano, M.: Translocation of a "winner" climbing fiber to the Purkinje cell dendrite and subsequent elimination of "losers" from the soma in developing cerebellum. Neuron 63: 106-118, (2009).
  5. Tanimura, A., Kawata, S., Hashimoto, K. & Kano, M.: Not glutamate but endocannabinoids mediate retrograde suppression of cerebellar parallel fiber to Purkinje cell synaptic transmission in young adult rodents. Neuropharmacology, 57: 157-163, (2009).
  6. Hildebrand, M., Isope, P., Miyazaki, T., Nakaya, T., Garcia, E., Feltz, A., Schneider, T., Hescheler, J., Kano, M., Sakimura, K., Watanabe, M., Dieudonné, S. & Snutch, T.P.: Functional coupling between mGluR1 and CaV3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines. J Neurosci, 29: 9668-9682, (2009).
  7. Hashimoto, K., Yoshida, T., Sakimura, K., Mishina, M., Watanabe, M. & Kano, M.: Influence of parallel fiber-Purkinje cell synapse formation on postnatal development of climbing fiber-Purkinje cell synapses. Neuroscience, 162: 601-611, (2009).
  8. Kano, M. & Hashimoto, K.: Synapse elimination in the central nervous system. Curr. Opin. Neurobiol., 19: 154-161, (2009).
  9. Sato, T., Miura, M., Yamada, M., Yoshida, T., Wood, J.D., Yazawa, I., Masuda, M., Suzuki, T., Shin, R.-M., Yau, H.-J., Liu, F.-C., Shimohata, T., Onodera, O., Ross, C.A., Katsuki, M., Takahashi, H., Kano, M., Aosaki, T. & Tsuji, S.: Severe neurological phenotypes of Q129 DRPLA transgenic mice serendipitously created by en masse expansion of CAG repeats in Q76 DRPLA mice. Hum. Mol. Genet. 15: 723-736 (2009).
  10. Kano M, Ohno-Shosaku T, Hashimotodani Y, Uchigashima M, Watanabe M: Endocannabinoid-mediated control of synaptic transmission. Physiol. Rev. 89: 309-380 (2009).

<2008>

  1. Kano, M., Hashimoto, K. & Tabata, T. : Type-1 metabotropic glutamate receptor in cerebellar Purkinje cells: a key molecule responsible for long-term depression, endocannabinoid signalling and synapse elimination. Phil. Trans. R. Soc. Lond. B. Biol. Sci. 363: 2173-2186 (2008).
  2. Kitamura, K., Judkewitz, B., Kano, M., Denk, W. & Hausser, M.: Targeted patch-clamp recordings and single-cell electroporation of unlabeled neurons in vivo. Nat. Methods 5: 61-67 (2008).
  3. Hashimotodani, Y., Ohno-Shosaku, T., Maejima, T., Fukami, K. & Kano, M.: Pharmacological evidence for the involvement of diacylglycerol lipase in depolarization-induced endocanabinoid release. Neuropharmacology 54: 58-67 (2008).

<2007>

  1. Kamikubo, Y., Tabata, T., Kakizawa, S., Kawakami, D., Watanabe, M., Ogura, A., Iino, M. & Kano, M.: Postsynaptic GABAB receptor signalling enhances LTD in mouse cerebellar Purkinje cells. J. Physiol. (Lond) 585: 549-563 (2007).
  2. Kina, S.-I., Tezuka, T., Kusakawa, S., Kishimoto, Y., Kakizawa, S., Hashimoto, K., Ohsugi, M., Kiyama, Y., Horai, R., Sudo, K., Kakuta, S., Iwakura, Y., Iino, M., Kano, M., Manabe, T. & Yamamoto T: Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression. Eur. J. Neurosci. 26: 2269-2278 (2007).
  3. Wada, N., Kishimoto, Y., Watanabe, D., Kano, M., Hirano, T., Funabiki, K. & Nakanishi, S.: Conditioned eyeblink learning is formed and stored without cerebellar granule cell transmission. Proc. Natl. Acad. Sci. USA. 104: 16690-16695. (2007).
  4. Ohno-Shosaku, T,. Hashimotodani, Y., Ano, M., Takeda, S., Tsubokawa, H. & Kano, M.: Endocannabinoid signalling triggered by NMDA receptor-mediated calcium entry into rat hippocampal neurons. J. Physiol. (Lond) 584: 407-418, (2007).
  5. Hashimotodani, Y., Ohno-Shosaku, T., Watanabe, M. & Kano, M.: Roles of phospholipase Cbeta and NMDA receptor in activity-dependent endocannabinoid release. J. Physiol. (Lond) 584: 373-380, (2007).
  6. Hashimotodani, Y., Ohno-Shosaku, T. & Kano, M.: Ca2+-assisted receptor-driven endocannabinoid release: mechanisms that associate presynaptic and postsynaptic activities. Curr. Opin. Neurobiol. 17: 360-365, (2007).
  7. Ohkawa, N., Hashimoto, K., Hino, T., Migishima, R., Yokoyama, M., Kano, M. & Inokuchi K: Motor discoordination of transgenic mice overexpressing a microtubule destabilizer, stathmin, specifically in Purkinje cells. Neurosci. Res., 59: 93-100, (2007).
  8. Tabata, T., Kawakami, D., Hashimoto, K., Kassai, H., Yoshida, T., Hashimotodani, Y., Fredholm, B. B., Sekino, Y., Aiba, A. & Kano, M.: G protein-independent neuromodulatory action of adenosine on metabotropic glutamate signaling in mouse cerebellar Purkinje cells. J. Physiol. (Lond), 581: 693-708, (2007).
  9. Hashimotodani, Y., Ohno-Shosaku, T. & Kano, M.: Endocannabinoids and synaptic function in the CNS. Neuroscientist 13: 127-137, (2007).
  10. Kakizawa, S., Kishimoto, Y., Hashimoto, K., Miyazaki, T., Furutani, K., Shimizu, H., Fukaya, M., Nishi, M., Sakagami, H., Ikeda, A., Kondo, H., Kano, M., Watanabe, M., Iino, M. & Takeshima, H.: Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity. EMBO J. 26: 1924-1933, (2007).
  11. Takagishi, Y., Hashimoto, K., Kayahara, T., Watanabe, M., Otsuka, H., Mizoguchi, A., Kano, M. & Murata, Y.: Diminished climbing fiber innervation of Purkinje cells in the cerebellum of myosin Va mutant mice and rats. Dev. Neurobiol. 67: 909-923, (2007).
  12. Nakao, H., Nakao, K., Kano, M. & Aiba, A.: Metabotropic glutamate receptor subtype-1 is essential for motor coordination in the adult cerebellum. Neurosci. Res. 57: 538-543, (2007).
  13. Uchigashima, M., Narushima, M., Fukaya, M., Katona,, I., Kano, M. & Watanabe, M.: Subcellular arrangement of molecules for 2-arachidonoyl-glycerol-mediated retrograde signaling and its physiological contribution to synaptic modulation in the striatum. J. Neurosci. 27: 3663-3676, (2007).
  14. Hashimotodani, Y., Ohno-Shosaku, T. & Kano, M.: Presynaptic monoacylglycerol lipase activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus. J. Neurosci. 27: 1211-1219, (2007).
  15. Narushima, M., Uchigashima, M., Fukaya, M., Matsui, M., Manabe, T., Hashimoto, K., Watanabe, M. & Kano, M.: Tonic enhancement of endocannabinoid-mediated retrograde suppression of inhibition by cholinergic interneuron activity in the striatum. J. Neurosci. 27: 496-506, (2007).

<2006>

  1. Narushima, M., Uchigashima, M., Hashimoto, K., Watanabe, M. & Kano, M.: Depolarization-induced suppression of inhibition mediated by endocannabinoids at synapses from fast-spiking interneurons to medium spiny neurons in the striatum. Eur. J. Neurosci. 24: 2246-2252, (2006).
  2. Fukaya, M., Tsujita, M., Yamazaki, M., Kushiya, E., Abe, M., Akashi, K., Natsume, R., Kano, M., Kamiya, H., Watanabe, M. & Sakimura, K.: Abundant distribution of TARP γ-8 in synaptic and extrasynaptic surface of hippocampal neurons and its major role in AMPA receptor expression on spines and dendrites. Eur. J. Neurosci. 24: 2177-2190, (2006).
  3. Kishimoto, Y. & Kano, M.: Endogenous cannabinoid signaling through the CB1 receptor is essential for cerebellum-dependent discrete motor learning. J. Neurosci. 26: 8829-8837, (2006).
  4. Miyazaki, T., Hashimoto, K., Uda, A., Sakagami, H., Nakamura, Y., Saito, S., Nishi, M., Kume, H., Tohgo, A., Kaneko, I., Kondo, H., Fukunaga, K., Kano, M., Watanabe, M. & Takeshima, H.: Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family. FEBS Lett. 580: 4057-4064, (2006).
  5. Yoshida, T., Fukaya, M., Uchigashima, M., Miura, E., Kamiya, H., Kano, M. & Watanabe, M.: Localization of diacylglycerol lipase-alfa around postsynaptic spine suggests close proximity between production site of an endocannabinoid, 2-arachidonoyl-glycerol, and presynaptic cannabinoid CB1 receptor. J. Neurosci. 26: 4740-4751, (2006).
  6. Kawamura, Y., Fukaya, M., Maejima, T., Yoshida, T., Miura, E., Watanabe, M., Ohno-Shosaku, T. & Kano, M.: The CB1 cannabinoid receptor is the major cannabinoid receptor at excitatory presynaptic site in the hippocampus and cerebellum. J. Neurosci. 26: 2991-3001, (2006).
  7. Narushima, M., Hashimoto, K. & Kano, M.: Endocannabinoid-mediated short-term suppression of excitatory synaptic transmission to medium spiny neurons in the striatum. Neurosci. Res. 54: 159-164, (2006).
  8. Kishimoto, Y., Nakazawa, K., Tonegawa, S., Kirino, Y. & Kano, M.: Hippocampal CA3 NMDA receptors are crucial for adaptive timing of trace eyeblink conditioned response. J. Neurosci. 26: 1562-1570, (2006).
  9. Yamasaki, M., Hashimoto, K. & Kano, M.: Miniature synaptic events elicited by presynaptic Ca2+ rise are selectively suppressed by cannabinoid receptor activation in cerebellar Purkinje cells. J. Neurosci. 26: 86-95, (2006).
  10. Tabata, T. & Kano, M.: GABAB receptor-mediated modulation of glutamate signaling in cerebellar Purkinje cells. Cerebellum 5: 127-133, (2006).

<2005>

  1. Hashimotodani, Y., Ohno-Shosaku, T., Tsubokawa, H., Ogata, H., Emoto, K., Maejima, T., Araishi, K., Shin, H.-S. & Kano, M.: Phospholipase Cbeta serves as a coincidence detector through its Ca2+ dependency for triggering endocannabinoid signal. Neuron 45: 257-268, (2005).
  2. Tabata, T., Haruki, S., Nakayama, H. & Kano, M.: GABAergic activation of an inwardly rectifying K+ current in mouse cerebellar Purkinje cells. J. Physiol. (Lond) 563: 443-457, (2005).
  3. Maejima, T., Oka, S., Hashimotodani, Y., Ohno-Shosaku, T., Aiba, A., Wu, D., Waku, K., Sugiura, T. & Kano, M.: Synaptically driven endocannabinoid release requires Ca2+-assisted metabotropic glutamate receptor subtype 1 to phospholipase C beta4 signaling cascade in the cerebellum. J. Neurosci. 25: 6826-6835 (2005).
  4. Kakizawa, S., Miyazaki, T., Yanagihara, D., Iino, M., Watanabe, M. & Kano, M.: Maintenance of presynaptic function by AMPA receptor-mediated excitatory postsynaptic activity in adult brain. Proc. Natl. Acad. Sci. USA. 102: 19180-19185, (2005).
  5. Ohno-Shosaku, T., Hashimotodani, Y., Maejima, T. & Kano, M.: Calcium signaling and synaptic modulation: Regulation of endocannabinoid-mediated synaptic modulation by calcium. Cell Calcium 38: 369-374, (2005).
  6. Hashimoto, K. and Kano, M. : Postnatal development and synapse elimination of climbing fiber to Purkinje cell projection in the cerebellum. Neurosci. Res. 53: 221-228, (2005).

<2004>

  1. Tabata, T., Araishi, K., Hashimoto, K., Hashimotodani, Y., van der Putten, H., Bettler, B. & Kano, M.: Ca2+ activity at GABAB receptors constitutively promotes metabotropic glutamate signaling in the absence of GABA. Proc. Natl. Acad. Sci. USA. 101: 16952-16957, (2004).
  2. Kitao, Y., Hashimoto, K., Matsuyama, T., Iso, H., Tamatani, T., Hori, O., Stern, D.M., Kano, M., Ozawa, K. & Ogawa, S.: ORP150/HSP12A regulates Purkinje cell survival: A role for ER stress in cerebellar development. J. Neurosci. 24: 1486-1496, (2004).
  3. Miyazaki, T., Hashimoto, K., Shin, H-S., Kano, M. & Watanabe, M.: P/Q-type Ca2+ channel alfa 1A regulates synaptic competition on developing cerebellar Purkinje cells. J. Neurosci. 24: 1734-1743, (2004).
  4. Fukudome, Y., Ohno-Shosaku, T., Matsui, M., Omori, Y., Fukaya, M., Tsubokawa, H., Taketo, M.M., Watanabe, M., Manabe, T. & Kano, M.: Two distinct classes of muscarinic action on hippocampal inhibitory synapses: M2-mediated direct suppression and M1/M3-mediated indirect suppression through endocannabinoid signaling. Eur. J. Neurosci., 19: 2682-2692, (2004).
  5. Hartmann, J., Blum, R.,. Kovalchuk, Y., Adelsberger, H., Kuner,R., Durand, G.M., Miyata, M., Kano, M., Offermanns, S. & Konnerth, A.: Distinct roles of G alfa q and G alfa 11 for Purkinje cell signaling and motor behavior. J. Neurosci. 24: 5119-5130 (2004).
  6. Kano, M., Ohno-Snosaku, T., Maejima, T., Yoshida, T. & Hashimoto, K.: Retrograde modulation of synaptic transmission mediated by endogenous cannabinoids. Curr. Neuropharmacol. 2: 49-57, (2004).
  7. Tabata, T. & Kano, M.: Calcium-dependence of native metabotropic glutamate receptor signaling in central neurons. Mol. Neurobiol. 29: 261-270, (2004).
  8. Sato, M., Tabata, T., Hashimoto, K., Nakamura, K., Nakao, K., Katsuki, M., Kitano, J., Moriyoshi, K., Kano, M. & Nakanishi, S.: Altered agonist sensitivity and desensitization of neuronal mGluR1 responses in knock-in mice by a single amino acid substitution at the PKC phosphorylation site. Eur. J. Neurosci. 20: 947-955 (2004).
  9. Yamazaki, M., Ohno-Shosaku, T., Fukaya, M., Kano, M., Watanabe, M. & Sakimura, K.: A novel action of stargazin as an enhancer of AMPA receptor activity. Neurosci. Res. 50: 369-374, (2004).
  10. Fukaya, M., Araishi, K., Aiba, A., Kano, M. & Watanabe, M.: Signaling complex formation of phospholipase C beta 4 with mGluR1a and IP3 receptor at the perisynapse and endoplasmic reticulum in the mouse brain. Eur. J. Neurosci. 20: 2929-2944 (2004).

<2003>

  1. Hashimoto, K. & Kano, M.: Functional differentiation of multiple climbing fiber inputs during synapse elimination in the developing cerebellum. Neuron 38: 785-796, (2003).
  2. Kakizawa, S., Yamada, K., Iino, M., Watanabe, M. & Kano, M.: Effects of insulin-like growth factor I on climbing fiber synapse elimination during cerebellar development. Eur. J. Neurosci. 17: 545-554, (2003).
  3. Fukudome, Y., Tabata, T., Miyoshi, T., Haruki, S., Araishi, K., Sawada, S. & Kano, M.: Insulin-like growth factor-I as a promoting factor for cerebellar Purkinje cell development. Eur. J. Neurosci. 17: 2006-2016, (2003).
  4. Ohno-Shosaku, T., Matsui, M., Fukudome, Y., Shosaku, J., Tsubokawa, H., Taketo, M.M., Manabe, T., & Kano, M.: Postsynaptic M1 and M3 receptors are responsible for the muscarinic enhancement of retrograde endocannabinoid signaling in the hippocampus. Eur. J. Neurosci. 18: 109-116, (2003).
  5. Takeda, Y., Akasaka, K., Lee, S., Kobayashi, S., Kawano, H., Murayama, S., Takahashi, N., Hashimoto, K., Kano, M., Asano, M., Sudo, K., Iwakura, Y. & Watanabe, K.: Impaired motor coordination in mice lacking neural recognition molecule NB-3 of the contactin/F3 subgroup. J. Neurobiol. 56: 252-265, (2003).

<2002>

  1. Tabata, T. & Kano, M.: Heterogeneous intrinsic hiring properties of vertebrate retinal ganglion cells. J. Neurophysiol. 87: 30-41, (2002).
  2. Yoshida, T., Hashimoto, K., Zimmer, A., Maejima, T., Araishi, K. & Kano, M.: The cannabinoid CB1 receptor mediates retrograde signals for depolarization-induced suppression of inhibition in cerebellar Purkinje cells. J. Neurosci. 22: 1690-1697, (2002).
  3. Ohno-Shosaku, T., Shosaku, J., Tsubokawa, H. & Kano, M.: Cooperative endocannabinoid production by neuronal depolarization and group I metabotropic glutamate receptor activation. Eur. J. Neurosci. 15: 953-961, (2002).
  4. Kano, M., Ohno-Snosaku, T. & Maejima, T.: Retrograde signaling at central synapses via endogenous cannabinoids. Mol. Psychiatry 7: 234-235, (2002).
  5. Ohno-Shosaku, T., Tsubokawa, H., Mizushima, I., Yoneda, N., Zimmer, A. & Kano, M.: Presynaptic cannabinoid sensitivity is a major determinant of depolarization-induced retrograde suppression at hippocampal synapses. J. Neurosci. 22: 3864-3872, (2002).
  6. Tabata, T., Aiba, A. & Kano, M.: Extracellular calcium controls the dynamic range of neuronal metabotropic glutamate receptor responses. Mol. Cell. Neurosci. 20: 56-68, (2002).
  7. Nishi, M., Hashimoto, K., Kuriyama, K., Komazaki, S., Kano, M., Shibata, S. & Takeshima, H.: Motor discoordination in mutant mice lacking junctophilin type 3. Biochem. Biophysic. Res. Comm. 292: 318-324, (2002).
  8. Watase, K., Weeber, E.J., Xu, B., Antalffy, B., Yuva-Paylor, L., Hashimoto, K., Kano, M., Atkinson, R., Sun, Y., Armstrong, D.L., Sweatt, D., Orr, H.T., Paylor, R. & Zoghbi, H.Y.: A long CAG repeat in the mouse Sca1 locus replicates SCA1 features and reveals the impact of mutant protein solubility on selective neuronal vulnerability. Neuron 34: 905-919, (2002)
  9. Miura, M., Watanabe, M., Offermanns, S., Simon, M.I. & Kano, M.: Group I mGluR signaling via G alfa q/G alfa 11 secures the induction of long-term potentiation in the hippocampal area CA1. J. Neurosci. 22: 8379-8390, (2002).
  10. Ichikawa, R., Miyazaki, T., Kano, M., Hashikawa, T., Tatsumi, H., Sakimura, K., Mishina, M., Inoue, Y. & Watanabe, M.: Distal extension of climbing fiber territory and multiple innervation caused by aberrant wiring to adjacent spiny branchlets in cerebellar Purkinje cells lacking glutamate receptor GluR delta 2. J. Neurosci. 22: 8487-8503, (2002).
  11. Kishimoto, Y., Fujimichi, R., Araishi, K., Kawahara, S., Kano, M., Aiba, A. & Kirino, Y.: mGluR1 in cerebellar Purkinje cells is required for normal association of temporally contiguous stimuli in classical conditioning. Eur. J. Neurosci. 16: 2416-2424, (2002).

<2001>

  1. Ohno-Shosaku, T., Maejima, T. & Kano, M.: Endogenous cannabinoids mediate retrograde signals from depolarized postsynaptic neurons to presynaptic terminals. Neuron 29: 729-738, (2001).
  2. Maejima, T., Hashimoto, K., Yoshida, T., Aiba, A. & Kano, M.: Presynaptic inhibition caused by retrograde signal from metabotropic glutamate to cannabinoid receptors. Neuron 31: 463-475, (2001).
  3. McGee, A.W., Topinka, J.R., Hashimoto, K., Petralia, R.S., Kakizawa, S., Kauer, F., Aguilera-Moreno, A., Wenthold, R.J., Kano, M. & Bredt, D.S.: PSD-93 knock-out mice reveal that neuronal MAGUKs are not required for development or function of parallel fiber synapses in cerebellum. J. Neurosci. 21: 3085-3091, (2001).
  4. Hashimoto, K., Ichikawa, R., Takechi, H., Inoue, Y., Aiba, A., Sakimura, K., Mishina, M., Hashikawa, T., Konnerth, A., Watanabe, M. & Kano, M. : Roles of GluR delta 2 and mGluR1 in climbing fiber synapse elimination during postnatal cerebellar development. J. Neurosci. 21: 9701-9712, (2001).
  5. Miyata, M., Kim, H-T., Hashimoto, K., Lee, T-K., Cho, S-Y., Jiang, H., Wu, Y., Jun, K., Wu, D., Kano, M. & Shin, H-S.: Deficient long-term synaptic depression in the rostral cerebellum correlated with impaired motor learning in phospholipase C beta 4 mutant mice. Eur. J. Neurosci. 13: 1945-1954, (2001).
  6. Hashimoto, K., Miyata, M., Watanabe, M. & Kano, M.: Roles of phospholipase C beta 4 in synapse elimination and plasticity in developing andf mature cerebellum. Mol. Neurobiol. 23: 69-82, (2001).
  7. Maejima, T., Ohno-Snosaku, T. & Kano, M.: Endogenous cannabinoid as a retrograde messenger from depolarized postsynaptic neurons to presynaptic terminals. Neurosci. Res. 40: 205-210, (2001).

<2000>

  1. Ichise, T., Kano, M., Hashimoto, K., Yanagihara, D., Nakao, K., Shigemoto, R., Katsuki, M. & Aiba, A.: mGluR1 in cerebellar Purkinje cells essential for long-term depression, climbing fiber synapse elimination and motor coordination. Science 288: 1832-1835, (2000).
  2. Miyata, M., Finch, E.A., Khiroug. L., Hahimoto,K., Hayasaka, S., Oda, S., Inouye, M., Takagishi, Y., Augustine, G.J., & Kano, M. :Local calcium release in dendritic spines required for long-term synaptic depression. Neuron 28: 233-244, (2000).
  3. Furuya, S., Tabata, T., Mitoma, J., Yamada, K., Yamasaki, M., Makino, A., Yamamoto, T., Watanabe, M., Kano, M. & Hirabayashi, Y.: L-Serine and glycine serve as major astroglia-derived trophic factors for cerebellar Purkinje neurons. Proc. Natl. Acad. Sci. USA. 97: 11528-11533, (2000).
  4. Kobayashi, K., Noda, Y., Matsushita, N., Nishii, K., Sawada, H., Nagatsu, T., Nakahara, D., Fukabori, R., Yasoshima, Y., Yamamoto, T., Miura, M., Kano, M., Mamiya, T., Miyamoto, Y. & Nabeshima, T.: Modest Neuropsychological deficits caused by reduced noradrenaline metabolism in mice heterozygous for a mutated tyrosine hydroxylase gene. J. Neurosci. 20: 2418-2426, (2000).
  5. Tsubokawa, H., Offermanns, S., Simon, M. I. & Kano, M.: Calcium-dependent persistent facilitation of spike backpropagation in the CA1 pyramidal neurons. J. Neurosci. 20: 4878-4884, (2000).
  6. Kakizawa, S., Yamasaki, M., Watanabe, M. & Kano, M.: Critical period for activity-dependent synapse elimination in developing cerebellum. J. Neurosci. 20: 4954-4961, (2000).
  7. Tanaka, J., Nakagawa, S., Kushiya, E., Yamasaki, M., Fukaya, M., Iwanaga, T., Simon, M. I., Sakimura, K., Kano, M. & Watanabe, M.: Gq protein subunits Gq and G11 are localized at the postsynaptic extra-junctional membrane of cerebellar Purkinje cells and hippocampal pyramidal cells. Eur. J. Neurosci. 12: 781-792, (2000).
  8. Matsuzawa, M., Tabata, T., Knoll, W. & Kano, M. : Formation of hippocampal synapses on patterned substrates of a laminin-derived synthetic peptide. Eur. J. Neurosci. 12: 903-910, (2000).
  9. Ohno-Shosaku, T., Sawada, S. & Kano, M.: Heterosynaptic expression of depolarization-induced suppression of inhibition (DSI) in rat hippocampal cultures. Neurosci. Res. 36: 67-71, (2000).
  10. Tabata, T., Sawada, S., Araki, K., Bono, Y., Furuya, S. & Kano, M.: A reliable method for culture of dissociated mouse cerebellar cells enriched for Purkinje Neurons. J. Neurosci. Meth. 104: 45-53, (2000).
  11. Hashimoto, K., Watanabe, M., Kurihara, H., Offermanns, S., Jiang, H., Wu Y., K. Jun, K., Shin, H-S, Inoue, Y., Wu, D., Simon, M. I. & Kano, M.: Climbing fiber synapse elimination during postnatal cerebellar development requires signal transduction involving G alfa q and phospholipase Cbeta 4. Prog. Brain Res. 124: 31-48, (2000).

<1999>

  1. Miyata, M., Okada, D., Hashimoto, K., Kano, M. & Ito, M. : Corticotropin-releasing factor plays a permissive role in cerebellar long-term depression. Neuron 22: 763-775, (1999).
  2. Hashimoto, K., Fukaya, M., Qiao, X., Sakimura, K., Watanabe, M. & Kano, M. : Impairment of AMPA receptor function in cerebellar granule cells of ataxic mutant mouse Stargazer. J. Neurosci. 19: 6027-6036, (1999).
  3. Tsubokawa, H., Miura, M. & Kano, M. :Elevation of intracellular Na+ induced by hyperpolarization at the dendrites of pyramidal neurones of mouse hippocampus. J. Physiol. (LonD) 517: 135-142, (1999).

<1998>

  1. Watanabe, D., Inokawa, H., Hashimoto, K., Suzuki, N., Kano, M., Shigemoto, R., Hirano, T., Toyama, K., Kaneko, S., Yokoi, M., Moriyoshi, K., Suzuki, M., Kobayashi, K., Nagatsu, T., Kreitman, R., Pastan, I. & Nakanishi, S. : Ablation of cerebellar Golgi cells disrupts synaptic integration involving GABA inhibition and NMDA receptor activation in motor coordination. Cell 95: 17-27, (1998).
  2. Kano, M., Hashimoto, K., Watanabe, M., Kurihara, H., Inoue, Y., Offermanns, S., Jiangs, H., Wu, Y., Jun, K., Shin, H-S., Simon, M.I. & Wu, D. : PLCbeta 4 is specifically involved in climbing fiber synapse elimination in the developing cerebellum. Proc. Natl. Acad. Sci. USA. 95: 15724-15729, (1998).
  3. Hashimoto, K. & Kano, M.: Presynaptic origin of paired-pulse depression at climbing fibre to Purkinje cell synapses in the rat cerebellum. J. Physiol. (Lond) 506: 391-405, (1998).
  4. Watase, K., Hashimoto, K., Kano, M., Yamada, K., Watanabe, M., Inoue, Y., Okuyama, S., Sakagawa, T., Ogawa, S-I., Kawashima, N., Hori, S., Takimoto, M., Wada, K. & Tanaka, K.: Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice. Eur. J. Neurosci. 10: 976-988, (1998).
  5. Watanabe, M., Nakamura, M., Sato, K., Kano, M., Simon, M. & Inoue Y.: Patterns of expression for the mRNA corresponding to the four isoforms of phospholipase Cbeta in mouse brain. Eur. J. Neurosci. 10: 2016-2025, (1998).

<1997>

  1. Kano, M., Hashimoto, K., Kurihara, H., Watanabe, M., Inoue, Y., Aiba, A. & Tonegawa, S.: Persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking mGluR1. Neuron 18: 71-79, (1997).
  2. Offermanns, S., Hashimoto, K., Watanabe, M., Sun, W., Kurihara, H., Thompson, R.F., Inoue, Y., Kano, M. & Simon, M.I. : Impaired motor coordination and persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking G alfa q. Proc. Natl. Acad. Sci. USA. 94: 14089-14094, (1997).
  3. Kurihara, H., Hashimoto, K., Kano, M., Takayama, C., Sakimura, K., Mishina, M., Inoue, Y. & Watanabe, M. : Impaired parallel fiber-Purkinje cell synapse stabilization during cerebellar development of mutant mice lacking the glutamate receptor delta 2 subunit (GluR delta 2). J. Neurosci. 17: 9613-9623, (1997).
  4. Tokunakga, M., Kitamura, K., Saito, K., Iwane, A. H. & Yanagida, T. : Single Molecule Imaging of Fluorophores and Enzymatic Reactions Achieved by Objective-type Total Internal Reflection Fluorescence Microscopy. Biochem. Biophys. Res. Commun. 235: 47-53 (1997).
  5. Iwane, A. H., Kitamura, K., Tokunakga M., & Yanagida, T. : Myosin Subfragment-1 Is Fully Equipped with Factors Essential for Motor Function. Biochem. Biophys. Res. Commun. 230: 76-80 (1997).
  6. Aoki, T., Hiroshima, M., Kitamura, K., Tokunaga, M. & Yanagida, T. : Non-contact scanning probe microscopy with sub-piconewton force sensitivity. Ultramicroscopy 70: 45-55 (1997).
  7. Tokunaga, M., Aoki, T., Hiroshima, M., Kitamura, K. & Yanagida, T. : Subpiconewton Intermolecular Force Microscopy. Biochem. Biophys. Res. Commun. 231: 566-569 (1997).

<1996>

  1. Kano, M., Kano, M-S., Fukunaga, K. & Konnerth, A.: Ca2+-induced rebound potentiation of ganma-aminobutyric acid-mediated currents requires activation of Ca2+/calmodulin-dependent kinase II. Proc. Natl. Acad. Sci. USA. 93: 13351-13356, (1996).
  2. Tempia, F., Kano, M., Schneggenburger, R., Schirra, C., Garaschuk, O., Plant, T. & Konnerth, A.: Fractional calcium current through neuronal AMPA receptor channels with a 'low' calcium permeability. J. Neurosci. 15: 456-466, (1996).
  3. Kano, M. : Long-lasting potentiation of GABAergic inhibitory synaptic transmission in cerebellar Purkinje cells: its properties and possible mechanisms. Behav. Brain Sci. 19: 354-361, (1996).
  4. Miyata, M., Hashimoto, K., Kano, M. & Ito, M. : Corticotropin releasing factor (CRF) induces long-lasting depression of parallel fiber to Purkinje cell synaptic transmission in rat cerebellum. J. Physiol. (Paris) 90: 419-120, (1996).

<1995>

  1. Kano, M., Hashimoto, K., Chen, C., Abeliovich, A., Aiba, A., Kurihara, H., Watanabe, M., Inoue, Y. & Tonegawa, S.: Impaired synapse elimination during cerebellar development in PKC gamma mutant mice. Cell 83: 1223-1231, (1995).
  2. Chen, C., Kano, M., Chen, L., Bao, S., Kim, J.J., Hashimoto, K., Thompson, R.F. & Tonegawa, S.: Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKC gamma mutant mice. Cell 83: 1233-1242, (1995).
  3. Kano, M., Garaschuk, O., Verkhratsky, A. & Konnerth, A. : Ryanodine receptor-mediated calcium release in rat cerebellar Purkinje neurones. J. Physiol. (Lond) 487: 1-16, (1995).
  4. Kano, M., Schneggenburger, R., Verkhratsky, A. & Konnerth, A.: Depolarization-induced calcium signals in the somata of cerebellar Purkinje neurons. Neurosci. Res. 24: 87-95, (1995).
  5. Kano, M.: Plasticity of inhibitory synapses in the brain: a possible memory mechanism that has been overlooked. Neurosci. Res. 21: 177-182, (1995).

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