Manabe Lab.

Department of Systems Medicine, Chiba University

We are interested in the molecular mechanisms of cardiovascular, metabolic, and kidney diseases and the translation of basic science into novel therapeutic strategies. Our current projects focus on immunometabolic mechanisms in chronic inflammatory diseases and the maintenance of homeostasis via multi-system interactions. We analyze the crosstalk between metabolism and immunity at the cellular, tissue, and systemic levels. We are particularly interested in the divergent functions and phenotypes of macrophages in physiology and pathobiology. We employ a variety of technologies, including NGS, single-cell analysis, FACS, and in vivo imaging.



Streamlit NGS Analysis App Suite

→ METIS


Our paper showing that hematopoietic stem cells carry a memory of heart failure, leading to heart failure recurrence as well as multimorbidity, is now published.

→ Science Immunology


Postdoc and Graduate Student Positions Available

Contact: imanabe@chiba-u.jp


Interests • Innate immune memory • Heart failure and multimorbidity • Organ crosstalk/Organ system networks • Epigenetics/Single-cell analysis • Macrophage biology • Immunometabolism • Inflammaging

Our research

Our long-term goal is to elucidate novel molecular mechanisms that maintain homeostasis through dynamic crosstalk between multiple organ systems and control the pathobiology of non-communicable diseases, such as heart failure, obesity, and cancer. We are currently working on the following projects:

  1. Innate immune memory in health and disease

  2. Novel functions and regulatory mechanisms of tissue-resident macrophages

  3. Neuro-immuno-metabolic regulation of cardiac homeostasis and heart failure

  4. Epigenetics in aging

  5. Physiological and pathological roles of chronic inflammation

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