Manabe Laboratory

Research Overview

Chronic inflammation and metabolic changes are common foundations for the onset of lifestyle diseases and cancer. We have been researching the role of chronic inflammation and metabolism in heart disease, metabolic syndrome, diabetes, chronic kidney disease, and cancer. Through these studies, we have found that immune cells, including macrophages, maintain the homeostasis of organs such as the heart.

Research Themes

1. Trained immunity as the basis of multimorbidity
2. Inter-organ communication in homeostasis and disease progression
3. Cellular metabolism and intercellular metabolic crosstalk
4. Novel regulatory mechanisms and functions of macrophages
5. Tissue microenvironment and epigenetics of tissue macrophages
6. Age-related chronic inflammation (inflammaging)
7. Link between inflammation and regeneration