Now, the tutorial video of our mouse vascular injury model (version 1 and 2 ) can be download  !!!

Click the right button of your mouse and save the file onto your computer. They could be viewed in QUICK TIME or Windows Media Player. Please feel free to copy the files for your colleagues.

*      Wire Injury Tutorial Video Version 1  ------  Higher Magnification (with narration)

        (You can learn how to insert the wire into the tiny artery.)

 

           Sata Model The wire injury1.mpg

 

 

*    Wire Injury Tutorial Video Version 2  ------  Lower Magnification (Silent).

        (You can learn how to control the femoral artery during the procedure.)

 

            Sata Model The wire injury 2.mpg

 

 

 

You can also view the tutorial video of our mouse vascular injury model (version 1 and 2 ) with narration on the internet (RealPlayer Version) !!!

 

Please install Rea Player Basic (Free).   

* I hear that some researchers experience problems in viewing the file due to some security guard in their institutes. If you E-mail to me, I am very happy to send you a free CD-ROM.  M.S.

 

 



Published Articles in which this model has been used.

By us

1. A mouse model of vascular injury that induces rapid onset of medial cell apoptosis followed by reproducible neointimal hyperplasia.

2. Acute and chronic smooth muscle cell apoptosis after mechanical vascular injury can occur independently of the Fas-death pathway.

3. Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis.

4. Mouse genetic evidence that tranilast reduces smooth muscle cell hyperplasia via a p21(WAF1)-dependent pathway.

5. Absence of p53 Leads to Accelerated Neointimal Hyperplasia After Vascular Injury.

6. Diverse Contribution of Bone Marrow Cells to Neointimal Hyperplasia After Mechanical Vascular Injuries.

7. Temporal and spatial characterization of cellular constituents during neointimal hyperplasia after vascular injury: Potential contribution of bone-marrow-derived progenitors to arterial remodeling.

8. Comparison of various bone marrow fractions in the ability to participate in vascular remodeling after mechanical injury.

9. Potent inhibitory effect of sirolimus on circulating vascular progenitor cells.

10. Circulating progenitor cells contribute to neointimal formation in non-irradiated chimeric mice.

 

By others

1. Platelets activated by collagen through immunoreceptor tyrosine-based activation motif play pivotal role in initiation and generation of neointimal hyperplasia after vascular injury.

2. Role of adiponectin in preventing vascular stenosis- the missing link of adipo-vascular axis -

3. Rosiglitazone facilitates angiogenic progenitor cell differentiation toward endothelial lineage: a new paradigm in glitazone pleiotropy.

4. R-Ras is a global regulator of vascular regeneration that suppresses intimal hyperplasia and tumor angiogenesis.

5. Granulocyte colony-stimulating factor (G-CSF) accelerates reendothelialization and reduces neointimal formation after vascular injury in mice.

6. Erythropoietin-mobilized endothelial progenitors enhance reendothelialization via Akt-endothelial nitric oxide synthase activation and prevent neointimal hyperplasia.

7. Tetrahydrobiopterin deficiency exaggerates intimal hyperplasia after vascular injury.

8. A role for muscle LIM protein (MLP) in vascular remodeling.

9. Stem cell factor deficiency is vasculoprotective: unraveling a new therapeutic potential of imatinib mesylate.

10. Inflammatory response to acute myocardial infarction augments neointimal hyperplasia after vascular injury in a remote artery.

11. Stem Cell Factor Attenuates Vascular Smooth Muscle Apoptosis and Increases Intimal Hyperplasia After Vascular Injury.

12. Leptin regulates neointima formation after arterial injury through mechanisms independent of blood pressure and the leptin receptor/STAT3 signaling pathways involved in energy balance.

13. Dimethylarginine dimethylaminohydrolase promotes endothelial repair after vascular injury.

14. Strain-dependent embryonic lethality and exaggerated vascular remodeling in heparin cofactor II-deficient mice.

15. Angiotensin II Receptor Blocker Inhibits Neointimal Hyperplasia Through Regulation of Smooth Muscle Like Progenitor Cells.

16. Blockade of vascular endothelial growth factor suppresses experimental restenosis after intraluminal injury by inhibiting recruitment of monocyte lineage cells.

17. Angiotensin II receptor blocker inhibits neointimal hyperplasia through regulation of smooth muscle-like progenitor cells.


 

 

We are confident that all researchers can reproduce our results following the procedure described in the video.  If you have question, please feel free to touch me.

I prefer to use COOK C-SF-15-15 (COOK INC. 1-812-339-2235). I usually cut the ends into 1 cm. You can use both ends. You can use both ends. If used gently, one piece can be re-used forever, in contrast to 2F Fogarty for rat carotid artery. It was about $9 when I was in United Sates. We also use clinical-grade guide wires.

I highly appreciate your interest in our model.

I look forward to hearing from you in future.

Masa Sata