A Case of Mitral Valve Replacement Complicated with Essential Thrombocythemia Preoperatively Interrupting Hydroxycarbamide

Kazuyoshi Hatada＊	Toshihiro Ishikawa＊	Keisuke Miyajima＊＊
Masao Takahashi＊＊

（Department of Cardiovascular Surgery, Odawara Municipal Hospital＊, Odawara, Japan, and Department of Cardiovascular Surgery, Hiratsuka Kyosai Heart Center, Hiratsuka Kyosai Hospital＊＊, Hiratsuka, Japan）

Essential thrombocythemia（ET）is a myeloproliferative neoplasm characterized by thrombocytosis and malfunction of platelets. Both thrombosis and bleeding due to thrombocytosis may occur. An 81-year-old female patient complicated with ET underwent mitral valve replacement using a bioprosthetic valve due to severe mitral regurgitation. She had been diagnosed and treated with the hydroxycarbamide for ET. The hydroxycarbamide had been interrupted 14 days before the surgery, to prevent infection and delayed wound healing. At hospitalization for surgery, her platelet count rose to 1,290,000/μl from 790,000/μl. Readministration of a half dose of the hydroxycarbamide lowered the platelets to her original level. During the operation, more heparin was necessary to control activated coagulation time for cardiopulmonary bypass. She was discharged unaffectedly on 25 POD.

 

Jpn. J. Cardiovasc. Surg. 48:401-404（2019）

Keywords：essential thrombocythemia;hydroxyurea;mitral valve replacement