Effect of Ultra-Short-Acting ƒÀ-Blocker Landiolol after Cardiovascular Surgery

iDepartment of Cardiovascular Surgery, Seirei Hamamatsu General Hospital, Hamamatsu, Japanj

Tadahisa Sugiura Masaaki Koide Yoshifumi Kunii
Nobuhiro Umehara Kazumasa Watanabe
Tachycardia caused by increased sympathetic nerve activity after cardiovascular surgery can induce an increase in myocardial oxygen consumption and myocardial ischemia. ƒÀ-Blockers are expected to reduce myocardial oxygen consumption, but traditional ƒÀ-blockers are long acting so it is difficult to use after cardiovascular surgery. >>From January 2007 to September 2007, 24 out of 60 patients who underwent cardiovascular surgery were administered landiolol. The average heart rate before landiolol infusion was 99.5}16.5bpm and decreased to 89.5}10.7bpm after landiolol infusionip0.0008). Average systolic blood pressure before and after landiolol infusion was 109}16mmHg and 103}13mmHg, respectivelyip0.15). Average cardiac indexi14 patientsjbefore and after landiolol infusion was 3.29}0.83l/min/m2and 3.26}0.9l/min/m2, respectivelyip0.75). Four patientsi17%jhad atrial fibrillation during these hospital stay, whereas 20 patients out of 50 patientsi40%jwho underwent cardiovascular surgery before landiolol was usedifrom June 2006 to January 2007jhad atrial fibrillationip0.045). Landiolol can be effective and used safely after cardiovascular surgery.
  Jpn. J. Cardiovasc. Surg. 38:179-183i2009j