| Four Cases of Delayed Hypersensitivity Reaction to Vancomycinafter Cardiac Surgery |
(The Department of Cardiovascular Surgery,
Anjo Kosei Hospital, Anjo, Japan)
| Hitoshi Suzuki |
Shinji Kanemitsu |
Toshiya Tokui |
| Yuo Kanamori |
Yoshihiko Kinoshita |
|
|
We report 4 cases of delayed
hypersensitivity reaction to Vancomycin (VCM) after cardiac
surgery. Case 1: A patient developed sepsis and mediastinitis
after aortic valve replacement (AVR) for aortic valve insufficiency.
Case 2: A patient developed mediastinitis after coronary artery
bypass grafting (CABG) for effort angina pectoris.
Case 3: A patient developed pneumonia after AVR for aortic valve
infective endocarditis. Case 4: A patient developed sepsis after
CABG for acute myocardial infarction. All of them received VCM
intravenously and their infections improved. However, sudden
high fever, skin rush and eosinophilia occurred 12 or 13 days
after the initiation of therapy. These symptoms resolved
after halting VCM administration. We need to take examine
eosinophils when considering further administration of VCM.
Jpn. J. Cardiovasc. Surg. 34：190-193 (2005) |
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