| The Effect of FR-167653 on Postoperative
Intimal Hyperplasia of the Interposition Vein Graft in Rat |
| Mitsuhiro Yamamura |
Takashi Miyamoto |
Hideki Yao |
(Department of Cardiovascular Surgery, Hyogo College
of Medicine, Nishinomiya, Japan)
|
Recently we reported that tumor
necrosis factor-ż (TNF-ż) mRNA expression and the development
of postoperative intimal hyperplasia (IH) is different in rat
epigastric vein interposition graft, compared to femoral artery
re-anastomosis. We evaluated whether a TNF-ż suppressive agent,
FR-167653 (Fujisawa Pharm. Co., Ltd., Osaka) could suppress IH
or not. Eleven Lewis male rats (480}8g) were studied. The epigastric
vein graft was interposed into the common femoral artery. They
were divided into two groups: group FR (n=5) with 2.0Ęg/g
of FR-167653, and group C (n=6) with same dose of saline
instead of FR-167653. The intimal areas of vein grafts were measured
at 4 weeks postoperatively. The mean intimal area in group FR
was significantly decreased, compared with group C (0.160}0.057mm2
vs. 0.434}0.045mm2, P<0.01). These results
suggest that the TNF-ż suppressive agent FR-167653 may suppress
the postoperative intimal hyperplasia that occurs on the interposition
vein graft in rats.
@Jpn. J. Cardiovasc. Surg. 31: 173-176 (2002) |
|
