| Reactivity of the Internal Thoracic
Artery Graft to Drugs in Coronary Artery Bypass Grafting |
| Katsunori Takeuchi |
Shigeru Sakamoto |
| Toshiaki Matsubara |
Yasuhiro Nagayoshi |
| Hisateru Nishizawa |
Shinji Shono |
| Michitaka Kohno |
Junichi Matsubara |
(Department of Thoracic and Cardiovascular Surgery,
Kanazawa Medical University, Ishikawa, Japan)
|
The internal thoracic artery is
a useful conduit for coronary artery bypass grafting (CABG).
Recently we have developed a method for increasing blood flow
by directly injecting a phosphodiesterase III (PDE III) inhibitor
into the left internal thoracic artery (LITA) to inflate the
artery and prevent its contraction. In the present study we compared
the reactivity of the LITA to three drugs: PDE III inhibitor,
papaverine hydrochloride and isosorbide dinitrate (ISDN). Forty-two
patients with a mean age of 66.8±11.5 years old who were undergoing
primary CABG were enrolled in this study and were randomly separated
into one of three groups based on the vasodilating drug administered.
Each drug was used in 14 cases. Graft free flow (GFF) and systemic
blood pressure were measured before and one minute after drug
administration to calculate blood vessel resistance (R).
All the drugs significantly increased GFF, and reduced both R
and blood pressure. A comparison of the change rate of blood
pressure did not differ significantly among the three drug groups.
The PDE III inhibitor significantly increased change rates of
both GFF and R, compared with the other drugs. These results
indicate that PDE III inhibitor is most effective for increasing
the blood flow of LITA grafts for CABG.
Jpn. J. Cardiovasc. Surg. 31：110-113(2002) |
|
