Role of Neutrophils in Ischemia/Reperfusion
Injury during Heart Surgery
Hidenori Gohra
Masahiko Nishida
Ken Hirata
Taro Shimazaki
Akihito Mikamo
Yoshitaka Ikeda
Haruhiko Okada
Kimikazu Hamano
Nobuya Zempo
Kensuke Esato
(First Department of Surgery, Yamaguchi University
School of Medicine, Ube, Japan)
To test the hypothesis that neutrophils
play a role in ischemia/reperfusion injury during heart surgery,
granulocyte elastase and myeloperoxidase release from coronary
circulation were measured before and after aortic cross-clamping.
The production of granulocyte elastase and myeloperoxidase across
the coronary circulation elevated significantly after release
of aortic cross-clamp. Furthermore, the level of granulocyte
elastase and myeloperoxidase released from coronary circulation
demonstrated positive correlation with the duration of the aortic
cross-clamp. These data indicate that neutrophils play a major
role in ischemia/reperfusion injury occurring during heart surgery.
Jpn. J. Cardiovasc. Surg. 31：8-11 (2002)
