Familial Aortic Dissection: A
Report of Four Cases in Two Families |
(Department of Surgery, Kurume University School
of Medicine, Kurume, Japan)
Satoru Tobinaga |
Hidetoshi Akashi |
Takayuki Fujino |
Shuji Fukunaga |
Shinsuke Hayashi |
Tomokazu Kosuga |
Koji Akasu |
Seiji Onitsuka |
Hideki Sakashita |
Shigeaki Aoyagi |
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There are rare reports of families
with multiple members with aortic dissection in the absence of
Marfan syndrome. We encountered four cases of aortic dissection
in two families. The aortic dissection occurred in the mother
and child of the first family and in sisters of the second family.
All cases had systemic hypertension preoperatively and presented
Stanford type A aortic dissection. All of them were operated
successfully. None of them showed the characteristics of connective
tissue disease affecting the skeletal, ocular, and cardiovascular
system. However, many members of the two families had systemic
hypertension and histopathological examination of the aorta showed
cystic medial necrosis in all of the four cases. The present
study suggests that the familial aortic dissection may be caused
by weakness of the aortic wall related to heredity and systemic
hypertension.
Jpn. J. Cardiovasc. Surg. 30: 161-164 (2001) |
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