| Role of Neutrophils in Pulmonary Dysfunction during Cardiopulmonary Bypass |
| Hidenori Gohra |
Tomoe Katoh |
Toshiro Kobayashi |
| Masahiko Nishida |
Ken Hirata |
Akihito Mikamo |
| Haruhiko Okada |
Kimikazu Hamano |
Nobuya Zempo |
| Kensuke Esato |
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(First Department of Surgery,Yamaguchi University School of Medicine, Ube, Japan)
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To test the hypothesis that neutrophils play a role in lung injury during
cardiopulmonary bypass, granulocyte elastase and myeloperoxidase release
from pulmonary circulation were measured, as well as the respiratory index,
before and after cardiopulmonary bypass. The production of granulocyte
elastase and myeloperoxidase in the pulmonary circulation, and the respiratory
index also elevated significantly after cadiopulmonary bypass. Furthermore,
the level of granulocyte elastase and myeloperoxidase released from pulmonary
circulation correlated with the changes of the repiratory index and preoperative
pulmonary artery pressure.These data indicate that
neutrophils play a major role in
pulmonary dysfunction occurring after cardiopulmonary bypass, which is
accentuated in patients with pulmonary hypertension.
Jpn. J. Cardiovasc. Surg. 29:363-367(2000) |
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