| ■ | 小山なつ 、等誠司: 慢性の痛みはどのように考えられてきたのか？ : 慢性の痛み －何によって生み出されているのか？ 加藤総夫先生監修 医学のあゆみ 260巻2号, 131〜134, 2017.1 |
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| ■ | 小山なつ 、等誠司: （Think about Pain）連載 第3回 痛みと鎮痛の歴史閑話3 ーフロイトと局所麻酔薬と催眠ー Practice of Pain Management 7(1). 30〜37, 2016.5 |
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■ 宮内諭（協力：小山なつ、小川節郎 ）: 痛みのサイエンス. Newton別冊 感覚―驚異のしくみ. 168-173, 2016
(ISBN978-4-315-52038-5) |
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| ■ | 小山なつ 、等誠司: （Think about Pain）連載 第2回 痛みと鎮痛の歴史閑話2 電気を使った痛みの治療の歴史 ーシビレエイとマラー、そしてマラーから. Practice of Pain Management 6(4). 30〜35, 2016.1 |
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| ■ | 小山なつ 、等誠司: 痛みの伝導路 ー歴史から学ぶー. 脊髄外科 29(3). 32-37, 2015 |
| ■ | 小山なつ、等誠司 : （Think about Pain）連載 第1回 痛みと鎮痛の歴史閑話1 聖アントニウスの火―St. Anthony's fire―. Practice of Pain Management 6(3). 32-37, 2015.11 |
| ■ | 小山なつ、等誠司 : 痛みのClinical neuroscience (2) 痛みの概念を歴史から振り返る最新毉学 70巻8号.1690〜1693, 2015. |
■ 小山なつ・等誠司: B 痛みの発生メカニズム.
1. 侵害受容器での侵害刺激の変換機構
2. 脊髄における侵害情報の処理
3. 脊髄からの上行路と痛みの発生機序
メカニズムから読み解く痛みの臨床テキスト（ 南江堂 小川節郎編集）. 56〜69, 2015
（ISBN : 978-4-524-26135-2） |
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| ■ | 小山なつ : 三叉神経支配領域の神経障害性疼痛 ―感覚生理学的見地から―. 頭痛学会誌 40 (1). 83-85, 2013. ［pdf］ |
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| □ | 小山なつ :三叉神経支配領域の神経障害性疼痛 ー感覚生理学的側面から. ＠第40回日本頭痛学会総会シンポジウム. Headache clinical science. 2013 Vol.4 No.1: 69. |
| ■ | 小山なつ : 痛みと鎮痛の基礎知識 ー痛みの学説と電気刺激鎮痛治療の歴史ー. 理学療法学 40 . 726-731, 2013. |
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| ■ | Iwashita N, Nosaka S, Koyama N : Involvement of peripheral NMDA receptor in melittin-induced thermographic flare. Neurochem Res. 2012 Oct;37(10):2222-2228. Epub 2012 Aug 1. [PubMed] [springer]
[DOI: 10.1007/s11064-012-0843-9] (ref 1/2 |
| ■ | 小山なつ : 触刺激と鎮痛反応. 自律神経 49(2). 83-85, 2012 |
| ■ | 小山なつ : 痛みの基礎メカニズム. Practice of Pain Management 3(2). 62-63, 2012.6 |
■ 宮内諭（協力：小山なつ、小川節郎 ）: 痛みのサイエンス. Newton別冊 体のしくみと病気. 94-99, 2012
(ISBN 978-4-315-51936-5)
■ 宮内諭（協力：小山なつ、小川節郎 ）: Topic 痛みのサイエンス. Newton 12-13. 102-107, 2012 |
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■小山なつ：痛みと鎮痛の基礎知識 [上] 基礎編 ― 脳は身体の警告信号をどう発信するのか、技術評論社 (知りたい!サイエンス), P.1〜P.256, 2010.2.5
(ISBN 978-4-7741-4157-2)
■小山なつ：痛みと鎮痛の基礎知識 [下] 臨床編 ― さまざまな痛みと治療法、技術評論社 (知りたい!サイエンス), P.1〜P.256, 2010.2.5
(ISBN 978-4-7741-4158-9) |
![痛みと鎮痛の基礎知識[上]基礎編、技術評論社](../IMG/painrelief1.jpg) |
![痛みと鎮痛の基礎知識[下]臨床編、技術評論社](../IMG/painrelief2.jpg) |
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| ■ | 小山なつ：第3章5節 内因性疼痛抑制系の機序. 慢性疼痛における薬剤選定と治療薬開発. 161-164, 2010
(ISBN:4861043344) |
| ■ | 小山なつ : 痛みからの解放の歴史 −戦争がもたらした痛みを巡って. Practice of Pain Management 1. 22-25, 2010 |
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| ■ | 小山なつ：内因性疼痛抑制系とその意義*. ペインクリニック. Vol.30 No.3: 373-381, 2009.3. |
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| ■ | Natsu Koyama, Yasuo Nisihikawa: Inhibitory effect of midbrain stimulation on sensory aspect of pain and on emotional aspect of pain. In: K. Kumamoto, Editor, Cellular and molecular mechanisms for the modulation of nociceptive transmission in the peripheral and central nervous systems*. Research Signpost, Trivandrum, Kerala, India, 2007, pp. 167-191.
[ISBN 81-308-0162-0]
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| □ |  A. I. バスバウム／D. ジュリアス（訳監修 小山なつ）: 痛みを抑える、別冊日経サイエンス 感覚と錯覚のミステリー: （日経サイエンス編集部編）日経サイエンス, 2007, 92-100
(ISBN-13: 978-4532511579)
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| ■ | Koyama N, Iwashita N : Melittin-induced neurogenic inflammation is increased through activationå of peripheral glutamate receptors. Pain Research 22: 35-41, 2007.
（小山なつ、 岩下成人 メリチンによる神経性炎症は末梢グルタミン酸受容体を介する）
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| ■ | 小山なつ、岩下成人、堀浩一郎、平田和彦：ハチ毒メリチンによる感覚性軸索反射と交感神経反射.自律神経. 43巻4号: 321-326, 2006. |
| □ | A. I. バスバウム／D. ジュリアス（訳監修 小山なつ）: 痛みを抑える新薬開発の最前線. 日経サイエンス: 42-50, September, 2006. →関連
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| ■ | Junichi Kitagawa, Kenro Kanda, Miho Sugiura, Yoshiyuki Tsuboi, Akiko Ogawa, Kohei Shimizu, Natsu Koyama, Hiroshi Kamo, Tatsuhisa Watanabe, Ke Ren and Koichi Iwata: Effect of Chronic Inflammation on Dorsal Horn Nociceptive Neurons in Aged Rats. J Neurophysiol 93: 3594-3604, January 19, 2005. [PubMed] [JNP]
(DOI: 10.1152/jn.01075.2004)
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| ■ | Iwashita N, Koyama N: Pain and axon reflex induced by subcutaneous injection of glutamate. Pain Research 19: 91-97, 2004.
（岩下成人、小山なつ グルタミン酸皮下注射による痛みと軸索反射）
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| ■ | Koyama N: Modulation of thalamic nociceptive transmission. Functional Neurosurgery 42: 1-5, 2003.
（小山なつ: 視床における痛覚伝達の制御. 機能的脳神経外科 42-1: 1-5, 2003) |
| ■ | Koyama N, Yokota T: Axon reflex and sympathetic activities induced by melittin in rat. Pain Research 18: 49-55, 2003.
（小山なつ、横田敏勝 メリチン皮下投与によるラットの軸索反射と交感神経活動）
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| ■ | Koyama N, Hirata K, Hori K, Dan K, Yokota T: Biphasic vasomotor reflex responses of the hand skin following intradermal injection of melittin into the forearm skin. Eur J Pain 6(6): 447-453, 2002 [PubMed][EJP]
[DOI: 10.1016/S1090-3801(02)00029-0]
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| ■ |  小山なつ: 「5. 視床における痛覚伝達の制御」・視床 【神経科学の基礎と臨床IX】（板倉徹、前田敏博編）東京、ブレーン出版, 2002, pp81-100 *
(ISBN：4-89242-191-X)
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| ■ | 小山なつ: 「腹痛の薬理学」・（特集 腹痛 そのメッセージをどう読むか？）モダンフィジシャン21(12) : 1608-1611, 2001
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| ■ | Ichikawa K, Koyama N, Kiguchi S, Kojima M, Yokota T: Inhibitory effect of oxcarbazepine on high-frequency firing in peripheral nerve fibers. Eur J Pharmacol 420: 119-122, 2001. May [PubMed]
[EJP]
[doi:10.1016/S0014-2999(01)01007-X] |
| ■ | 横田敏勝, 小山なつ: 「星状神経節ブロックの生理学的意義」・星状神経節ブロックの生理的意義 （小川節郎編）、東京、真興交易（株）医学出版部, 2001, pp15-24
|*
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| ■ | Koyama N, Nishio T, Yokota T: Non-serotonergic midbrain neurons are involved in picrotoxin-induced analgesia. An immunohistochemical study in the rat. Neurosci lett 291(3): 147-150, 2000 Sept. [PubMed]
[ScienceDirect]
[doi:10.1016/S0304-3940(00)01387-2]
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| ■ | 小山なつ, 横田敏勝 : 神経成長因子と痛み・日本ペインクリニック学会誌 [Koyama N, Yokota T: Nerve Growth Factor and Pain. Jounal of Japan Society of Pain Clinicians] 17(2) : 103-115, 2000 [Abstract] |
| ■ | Koyama N, Hirata K, Hori K, Dan K, Yokota T: Computer-assisted infrared thermographic study of axon reflex induced by intradermal melittin. Pain 84(2-3): 133-139, 2000 June
[PubMed]
[Ovid]
[DOI: 10.1016/S0304-3959(99)00192-X] |
| ■ | Dan K, Yokota T, Koyama N, Hirata H, Hori K: Mechanism-based treatment of Zonster-associatd Pain. Pain Review 7: 121-144, 2000 [Ingenta]
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| ■ | Nishikawa Y, Koyama N, Yoshida Y, Yokota T: Activation of ascending antinociceptive system by vagal afferent input as revealed in the nucleus ventralis posteromedialis. Brain Res 833(1) : 108-111, 1999 June [PubMed]
[ScienceDirect]
[doi:10.1016/S0006-8993(99)01521-8] |
| ■ | 小山なつ, 横田敏勝 : 侵害受容の系統発生・日本生理学雑誌 [Koyama N, Yokota T: Phylogeny of nociception Nippon Seirigaku Zasshi] 61(7-8) : 261-277, 1999 [PubMed]
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| ■ | Koyama N, Hanai F, Yokota T: Dose intravenous adminisration of GABAA receptor antagonists induced both descending antinociceptive and touch-evoked allodynia? Pain 76: 327-336, 1998
[PubMed]
[ScienceDirect] |
| ■ | Koyama N, Nishikawa Y, Yokota T: Distribution of nociceptive neurons in the ventrobasal complex of macaque thalamus. Neurosci Res 31: 39-51, 1998
[PubMed]
[ScienceDirect] |
| ■ | Chen J, Koyama N: Differntial activation of spinal dorsal horn units by subcutaneous formalin injection in the cat: an electrophysiological study. Exp Brain Res 118: 14-128, 1998
[PubMed]
[Abstract] |
| ■ | Chen J, Koyama N, Kaneko T, Mizuno N, Distribution of μ - opioid receptor-like immunoreactivity in the brain of the Japanese monkey (Macacafuscata). I. Diencephalon and brain stem. Chin J Neuroanatomy 14: 101-110. 1998 |
| ■ | Chen J, Koyama N, Kaneko T, Mizuno N, Distribution of μ - opioid receptor-like immunoreactivity in the brain of the Japanese monkey (Macaca fuscata). II. Rostrocaudal neuraxis of spinal cord and dorsal root ganglia. Chin J Neuroanatomy 14: 321-327. 1998 |
| ■ | 小山なつ, 横田敏勝： 痛みのメカニズム ・がん看護. 75:1462-1465. 1998 * |
| ■ | 横田敏勝, 小山なつ： 痛みはどうして起こるのか・臨床と研究. 31: 6-10. 1998 |
| ■ | 横田敏勝, 壇健二郎, 小山なつ： :帯状疱疹の痛みのメカニズム・日本ペインクリニック学会誌 [ Yokota T, Dan K, Koyama N,: Pain Mechanisms in Herpes Zoster. Jounal of Japan Society of Pain Clinicians] 5(2) : 112-118, 1998
[Abstract]
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| ■ | Koyama N, Morikochi Y, Yokota T: Inhibition of high frequency firing of peripheral nerve fiber following intravenous lidocaine administration. (Preliminary report) Pain Res 12: 115-120, 1997 |
| ■ | Osada A, Fujino Y, Chen J, Koyama N: Differential effects of ketamine and MK-801 on A-fiber and C-fiber responses of spinal wide dynamic range neurons in the cat. J Anesthesia 11: 184-192, 1997 [SplingreLink] |
| ■ | Chen J, Koyama N, Kaneko T, Mizuno N: The locus coeruleus of the Japanese monkey (Macaca fuscata) does not express m-opioid receptor-like immunoreactivety. Brain Res 755: 326-330, 1997
[PubMed]
[Science Direct] |
| ■ | Kizuki N, Matsushita M, Koyama N, Effects of sensorimotor cortex stimulation on nociceptive neurons of nucleus ventralis posterolateralis in cats. J Shiga Univ Med Sci 12 31-49. 1997 |
| ■ | 横田敏勝, 小山なつ： 疼痛抑制系の生理. 滋賀医科大雑誌 12:1-3. 1997 |
| ■ | 横田敏勝, 小山なつ, 平田和彦： 炎症と痛み. ペインクリニック 18: 349-356. 1997 |
| ■ | 小山なつ, 西川泰央,横田敏勝： 鎮痛の生理. 痛みと漢方 7: 3-9. 1997 |
| ■ | 横田敏勝, 花井文彦, 小山なつ： 脊髄神経恨由来の痛みの病体解明の現状：生理学の立場から. Frontier 4: 9-13, 1997
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| ■ | Koyama N, Hanai F, Chen J, Yokota T.: Activation of descending antinociceptive system produced by intravenous picrotoxin. Pain Res 11: 85-95, 1996 |
| ■ | Yokota Y, Nishikawa Y, Koyama N, Fujino Y: Differential distribution of four types of tooth pulp neurons in the caudal medulla oblongata of cat. Brain Res 715 (1-2): 230-234, 1996 Apr
[PubMed]
[Science Direct]
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| ■ | Fujino Y, Yokota Y, Koyama N,: Differential distribution of three types of nociceptive neurons within the caudal bulbar reticular formation in the cat. Brain Res 715 (1-2) : 225-229, 1996 Apr
[PubMed]
[Science Direct] |
| ■ | Minami T, Koyama N, Amakata Y, Effects of osmotic pressure on intrathecal lidocaine anesthesia. J Anesth 10: 39-43. 1996 [SplingerLink] |
| ■ | Matsushita M, Kizuki N, Koyama N, Excitatory and inhibitory effects of vagal afferent input on nociceptive neurons in the nucleus ventralis posterolateralis of the cat thalamus. J Shiga Univ Med Sci 11 93-106. 1996 |
| ■ | Chen J, Koyama N, Yokota T, Effects of subcutaneous formalin on responses of dorsal horn wide dynamic range neurons and primary afferent neurons in the cat. Pain Res 11:71-83 1996 |
| ■ | Yokota T, Koyama N, Hirata K, Pathophysioloty of neuropathic pain. JJSPC 3(4): 1996
[Abstract]
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| ■ | Koyama N, Nishikawa Y, Chua AT, Iwamoto I, Yokota T.: Differential inhibitory mechanism in VPL versus intralaminar nociceptive neurons of the cat: I. Effects of periaqueductal gray stimulation. Jpn J Physiol 45(6) : 1005-1027, 1995
[PubMed]
[JLC] |
| ■ | Koyama N, Nishikawa Y, Chen J, Barderrama RP, Yokota T: Differential inhibitory mechanism in VPL versus intralaminar nociceptive neurons of the cat: II. Effects of systemic morphine and CCK. Jpn J Physiol 45(6): 1029-1041, 1995
[PubMed]
[JLC] |
| ■ | Hirata K, Koyama N, Minami T: The effects of clonidine and tizanidine on responses of nociceptive neurons in nucleus ventralis posterolateralis of the cat thalamus. Anesth Analg 81 (2) : 259-264, 1995 Aug
[PubMed][A & A]
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| ■ | Koyama N, Yokota T, Inhibition of activities of VPL nociceptive neurons by dorsal column stimulation. Pain Res 9: 77-86. 1994 |
| ■ | Nishikawa Y, Koyama N, Yoshida Y, and Yokota T, Brain and oral function, Effects of intravenous morphine on responses of thalamic nociceptive neurons in cats. Excerpta medica, pp617-620, 1994
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| ■ | Koyama Ｎ, Yokota T, Ascending inhibition of nociceptive neurons in the nucleus ventralis posterolateralis following conditioning stimulation of the nucleus raphe magnus, Brain Res 609(1-2): 298-306. 1993
[PubMed] |
| ■ | Nishikawa Y, Hasegawa A, Koyama N, Yokota T, Nucleus ventralis posteromedialis neurons relaying somatosensory lingual input to the cerebral cortex in the cat. Brain Res 605: 265-270. 1993
[PubMed]
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| ■ | Terada M, Yasuda H, Kikkawa R, Koyama N, Yokota T, Shigeta Y, Electrophysiological study of dorsal column function in streptozocin-induced diabetic rats: comparison with 2,5-hexanedione intoxication. J Neurol Sci. 1993 Mar;115(1):58-66.
[PubMed]
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| ■ | Nishikawa Y, Koyama N,Yokota T, Ascending inhibition of nociceptive neurons in the thalamic intralaminar nuclei following conditioning stimulation of the mesencephalic periaqueductal gray. Pain Res 7: 81-91. 1992
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| ■ | 高橋亨, 小山なつ, α2主動性チザニジンの筋肉内鎮静作用の基礎的研究・麻酔・ 751-765. 1992 |
| ■ | Yokota T, Koyama N, Horie H, Nishikawa Y, Processing and inhibition of nociceptive information, Thalamic mechanism of visceral pain: ascending inhibition of responses to visceral afferent input VPL and intralaminar nociceptive neurons. Excerpta medica, pp 135-140, 1992
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| ■ | Nishikawa Y, Koyama N, Hasegawa A, Fujino Y, Yokota T, Functional properties of trigeminal nociceptive neurons in the subnucleus reticularis ventralis of the cat. Pain Res 6: 699-703. 1991 |
| ■ | Yokota T, Koyama N, Nishikawa N, Hasegawa A, Trigeminal nociceptive neurons in the subnucleus reticularis ventralis. II. Ascending projection. Neurosci Res 11(1) : 18-27. 1991 June
[PubMed] |
| ■ | Yokota T, Koyama N, Nishikawa Y, Nishikawa N, Nishida Y, Hasegawa A, Fujino Y, Trigeminal nociceptive neurons in the subnucleus reticularis ventralis. I. Response properties and afferent connections. Neurosci Res 11(1) : 1-17. 1991 June
[PubMed]
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| ■ | Pamplin PJ, Chua AT, Koyama N, Horie H, Yokota T, Stimulation produced inhibition of nociceptive neurons in the nucleus ventralis posterolateralis of the cat. Pain Res 5: 1-8. 1990 |
| ■ | Koyama N, Terada M, Yokota T, Electrophysiological changes in the fasciculus gracilis of the cat following chronic clioquinol administration. J Neurol Sci 94: 271-282. 1990
[PubMed]
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| ■ | Yokota T, Asato F, Koyama N, Masuda T, Taguchi H, Nociceptive body representation in nucleus ventralis posterolateralis of cat thalamus. J Neurophysiol 60(5): 1714-1727. 1988 Nov
[PubMed][J Neurophysiol] |
| ■ | Yokota T, Koyama N, Nishikawa, Y Hasegawa, Dual somatosensory representation of the periodontium in nucleus ventralis posteromedialis of the cat thalamus. Brain Res 475(1): 187-191. 1988 Dec
[PubMed] |
| ■ | Nishikawa Y, Koyama N, Yokota T, Ipsilateral somatosensory tongue representation within the lateral subdivision of the nucleus ventralis posteromedialis parvocellularis of the cat thalamus. Brain Res 458(2): 394-396. 1988 Aug
[PubMed] |
| ■ | Yokota T, Nishikawa Y, Koyama N, Pain research and clinical management, Distribution of trigeminal nociceptive neurons in nucleus ventralis posteromedialis of primates. Elsevier, Vol 3: pp555-559, 1988
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| ■ | Yokota Y, Nishikawa N, Nishikawa Y, Koyama N, Taguchi H, Masuda T, Nomura T, Asato F, Biowarning system in the brain,Thalamic mechanism of nociception: nociceptive neurons in VPL of cat thalamus. University of Tokyo Press, pp17-30, 1987 |
| ■ | Yokota T, Masuda T, Taguchi H, Koyama N, Fine afferent nerve fibers and pain, Viscerosomatic convergence onto nociceptive neurons in the shell region of nucleus ventralis posterolateralis. VCH Verlagsgessellshaft, pp429-437, 1987 |
| ■ | Yokota T, Koyama N, Nishikawa N, Effects of injury on trigeminal and spinal somatosensory systems, Nociceptive neurons in the shell region of the ventrobasal complex of the thalamus. Alan R. Liss, Inc., pp305-312, 1987
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| ■ | 横田敏勝, 小山なつ, 増田卓也 、西川泰央, 痛みと大脳皮質. ペインクリニック 7：423-432, 1986 |
| ■ | Yokota T, Nishikawa Y, Koyama N, Tooth pulp input to the shell region of nucleus posteromedialis of the cat thalamus. J Neurophysiol 56(1): 89-98. 1986 Jul
[PubMed][J Neurophysiol] |
| ■ | Yokota T, Koyama N, Matsumoto N, Somatotopic distribution of trigeminal nociceptive neurons in ventrobasal complex of cat thalamus. J Neurophysiol 53(6) : 1387-1400. 1985 June
[PubMed]
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| ■ | Yokota T, Koyama N, Nishikawa N, Umehara H, [Physiological basis of trigeminal pain]. Masui 33(10) : 1056-1563. 1984 Oct
[PubMed]
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| ■ | Yokota T, Koyama N, Identification of neurons relaying trigeminal nociceptive input on to subnucleus reticularis ventralis in the cat. Neurosci Lett 36(3): 273-278. 1983 Apr
[PubMed]
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| ■ | Yokota T, Koyama N, Anatomical, physiological and pharmacological aspects of trigeminal pain, Responses evoked in the caudal medulla by stimulation of neck muscle afferents. Excerpta medica, pp103-118, 1982
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| ■ | 小山 なつ, トビケラ幼虫数種の巣と絹糸腺について( Cases and silk glands of some Trichoptera larvae ). 陸水生物学報1: 19-26. 1980
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