{"id":1947,"date":"2025-09-19T18:28:47","date_gmt":"2025-09-19T09:28:47","guid":{"rendered":"https:\/\/plaza.umin.ac.jp\/~OIO\/s2d\/?p=1947"},"modified":"2025-09-19T18:28:47","modified_gmt":"2025-09-19T09:28:47","slug":"%e3%82%aa%e3%83%94%e3%82%aa%e3%82%a4%e3%83%89%e8%aa%98%e7%99%ba%e6%80%a7%e4%be%bf%e7%a7%98%ef%bc%88oic%ef%bc%89%e3%81%ae%e6%b7%b1%e5%b1%a4%ef%bc%9a%e7%a5%9e%e7%b5%8c%e3%81%8b%e3%82%89%e8%85%b8","status":"publish","type":"post","link":"https:\/\/plaza.umin.ac.jp\/~OIO\/s2d\/2025\/09\/19\/%e3%82%aa%e3%83%94%e3%82%aa%e3%82%a4%e3%83%89%e8%aa%98%e7%99%ba%e6%80%a7%e4%be%bf%e7%a7%98%ef%bc%88oic%ef%bc%89%e3%81%ae%e6%b7%b1%e5%b1%a4%ef%bc%9a%e7%a5%9e%e7%b5%8c%e3%81%8b%e3%82%89%e8%85%b8\/","title":{"rendered":"\u30aa\u30d4\u30aa\u30a4\u30c9\u8a98\u767a\u6027\u4fbf\u79d8\uff08OIC\uff09\u306e\u6df1\u5c64\uff1a\u795e\u7d4c\u304b\u3089\u8178\u5185\u30a8\u30b3\u30b7\u30b9\u30c6\u30e0\u307e\u3067\u3001\u591a\u89d2\u7684\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u305d\u306e\u672a\u6765\u3092\u63a2\u308b"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u304c\u3093\u60a3\u8005\u306b\u304a\u3051\u308b\u30aa\u30d4\u30aa\u30a4\u30c9\u8a98\u767a\u6027\u4fbf\u79d8\uff08OIC\uff09\u306e\u4e3b\u8981\u30c6\u30fc\u30de\u3068\u91cd\u8981\u306a\u4e8b\u5b9f\u306b\u95a2\u3059\u308b\u8a73\u7d30\u306a\u8aac\u660e\u8cc7\u6599<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">1. \u306f\u3058\u3081\u306b<\/h3>\n\n\n\n<p>\u30aa\u30d4\u30aa\u30a4\u30c9\u8a98\u767a\u6027\u4fbf\u79d8\uff08OIC\uff09\u306f\u3001\u304c\u3093\u60a3\u8005\u306e\u75bc\u75db\u7ba1\u7406\u306b\u5e83\u304f\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u30aa\u30d4\u30aa\u30a4\u30c9\u306e\u4e00\u822c\u7684\u306a\u5408\u4f75\u75c7\u3067\u3042\u308a\u3001\u60a3\u8005\u306e\u4e88\u5f8c\u3068\u751f\u6d3b\u306e\u8cea\u306b\u8457\u3057\u3044\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002OIC\u306e\u75c5\u614b\u306f\u8907\u96d1\u3067\u3042\u308a\u3001\u52b9\u679c\u7684\u306a\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u3092\u56f0\u96e3\u306b\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u8aac\u660e\u8cc7\u6599\u306f\u3001\u63d0\u4f9b\u3055\u308c\u305f\u60c5\u5831\u6e90\u306b\u57fa\u3065\u3044\u3066\u3001OIC\u306e\u4e3b\u8981\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u6f5c\u5728\u7684\u306a\u6cbb\u7642\u6a19\u7684\u3092\u5305\u62ec\u7684\u306b\u30ec\u30d3\u30e5\u30fc\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">2. OIC\u306e\u5b9a\u7fa9\u3068\u8a3a\u65ad\u57fa\u6e96<\/h3>\n\n\n\n<p>OIC\u306f\u4ee5\u524d\u3001\u30aa\u30d4\u30aa\u30a4\u30c9\u8a98\u767a\u6027\u8178\u6a5f\u80fd\u969c\u5bb3\uff08OIBD\uff09\u306e\u4e00\u75c7\u72b6\u3068\u898b\u306a\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u73fe\u5728\u3067\u306f\u3001\u80c3\u8178\u79d1\u533b\u3001\u816b\u760d\u79d1\u533b\u3001\u8001\u5e74\u79d1\u533b\u3001\u75bc\u75db\u5c02\u9580\u533b\u306b\u3088\u308b\u5b66\u969b\u7684\u306a\u7ba1\u7406\u304c\u5fc5\u8981\u306a\u72ec\u7acb\u3057\u305f\u75be\u60a3\u3068\u3057\u3066\u8a8d\u8b58\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u8a3a\u65ad\u57fa\u6e96:<\/strong> OIC\u306e\u8a3a\u65ad\u306b\u306f\u3001\u30ed\u30fc\u30de\u57fa\u6e96\u304c\u5e83\u304f\u63a1\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u300c\u30aa\u30d4\u30aa\u30a4\u30c9\u306e\u958b\u59cb\u307e\u305f\u306f\u8ffd\u52a0\u5f8c\u306b\u65b0\u898f\u307e\u305f\u306f\u60aa\u5316\u3057\u305f\u4fbf\u79d8\u300d\u3067\u3042\u308a\u3001\u4ee5\u4e0b\u306e\u57fa\u6e96\u306e\u3046\u3061\u5c11\u306a\u304f\u3068\u30822\u3064\u3092\u6e80\u305f\u3059\u3082\u306e\u3067\u3059\u3002<\/li>\n\n\n\n<li>25%\u306e\u6392\u4fbf\u304c\u786c\u3044\u3001\u8457\u3057\u3044\u52aa\u529b\u304c\u5fc5\u8981\u3001\u307e\u305f\u306f\u4e0d\u5b8c\u5168\u3067\u3042\u308b\u3002<\/li>\n\n\n\n<li>\u809b\u9580\u9589\u585e\u304c\u5b58\u5728\u3057\u3001\u6392\u4fbf\u306b\u624b\u52d5\u306e\u88dc\u52a9\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002<\/li>\n\n\n\n<li>\u9031\u306b3\u56de\u672a\u6e80\u306e\u81ea\u767a\u7684\u6392\u4fbf\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li>\u4e0b\u5264\u3092\u4f7f\u7528\u3057\u306a\u3044\u9650\u308a\u3001\u8edf\u4fbf\u304c\u307b\u3068\u3093\u3069\u306a\u3044\u3002<\/li>\n\n\n\n<li><strong>\u6642\u9593\u7684\u95a2\u4fc2:<\/strong> \u30ed\u30fc\u30de\u57fa\u6e96\u306f\u3001\u30aa\u30d4\u30aa\u30a4\u30c9\u4f7f\u7528\u3068\u4fbf\u79d8\u3068\u306e\u9593\u306e\u56e0\u679c\u95a2\u4fc2\u304a\u3088\u3073\u6642\u9593\u7684\u95a2\u4fc2\u3092\u5f37\u8abf\u3057\u3066\u3044\u307e\u3059\u3002\u30a4\u30bf\u30ea\u30a2\u306e2021\u5e74\u306eOIC\u5c02\u9580\u5bb6\u30b3\u30f3\u30bb\u30f3\u30b5\u30b9\u3067\u306f\u3001OIC\u3092\u300c\u5c11\u306a\u304f\u3068\u30822\u9031\u9593\u4ee5\u4e0a\u306b\u308f\u305f\u3063\u3066\u51fa\u73fe\u307e\u305f\u306f\u60aa\u5316\u3057\u305f\u4fbf\u79d8\u75c7\u72b6\u306e\u5b58\u5728\u300d\u3068\u5b9a\u7fa9\u3057\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">3. OIC\u306e\u75c5\u614b\u30e1\u30ab\u30cb\u30ba\u30e0<\/h3>\n\n\n\n<p>OIC\u306f\u3001\u30aa\u30d4\u30aa\u30a4\u30c9\u304c\u8178\u7ba1\u306e\u8907\u6570\u306e\u5074\u9762\u306b\u4f5c\u7528\u3059\u308b\u591a\u56e0\u5b50\u6027\u306e\u30d7\u30ed\u30bb\u30b9\u3067\u3059\u3002\u4e3b\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">3.1 \u30aa\u30d4\u30aa\u30a4\u30c9\u53d7\u5bb9\u4f53\u306e\u4f5c\u7528<\/h4>\n\n\n\n<p>\u30aa\u30d4\u30aa\u30a4\u30c9\u306f\u3001\u30e2\u30eb\u30d2\u30cd\u53d7\u5bb9\u4f53\uff08MOR\uff09\u3001\u30c7\u30eb\u30bf\u30aa\u30d4\u30aa\u30a4\u30c9\u53d7\u5bb9\u4f53\uff08DOR\uff09\u3001\u30ab\u30c3\u30d1\u30aa\u30d4\u30aa\u30a4\u30c9\u53d7\u5bb9\u4f53\uff08KOR\uff09\u3001\u30ce\u30b7\u30bb\u30d7\u30c1\u30f3\u53d7\u5bb9\u4f53\uff08NOPR\uff09\u3001MRGPRX1\u3001MRGPRX2\u306a\u3069\u306e\u30aa\u30d4\u30aa\u30a4\u30c9\u30ea\u30ac\u30f3\u30c9\u7d50\u5408\u3092\u4ecb\u3057\u3066\u4f5c\u7528\u3057\u307e\u3059\u3002\u8178\u7ba1\u306b\u306f\u3059\u3079\u3066\u306e\u30aa\u30d4\u30aa\u30a4\u30c9\u53d7\u5bb9\u4f53\u30b5\u30d6\u30bf\u30a4\u30d7\u304c\u5b58\u5728\u3057\u3001\u4e2d\u3067\u3082MOR\u304c\u6700\u3082\u8c4a\u5bcc\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>MOR\u306e\u5206\u5e03:<\/strong> MOR\u306f\u3001\u8178\u7ba1\u7b4b\u3001\u7c98\u819c\u4e0b\u795e\u7d4c\u53e2\u3001\u56de\u8178\u306e\u7e26\u8d70\u7b4b\u306b\u4f4d\u7f6e\u3059\u308b\u514d\u75ab\u7d30\u80de\u306b\u8c4a\u5bcc\u306b\u5b58\u5728\u3057\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>DOR\u306e\u5206\u5e03:<\/strong> DOR\u306f\u5927\u5c0f\u8178\u306b\u5206\u5e03\u3057\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>KOR\u306e\u5206\u5e03:<\/strong> KOR\u306f\u7c98\u819c\u4e0b\u9818\u57df\u3001\u30ab\u30cf\u30fc\u30eb\u9593\u8cea\u7d30\u80de\uff08ICCs\uff09\u3001\u304a\u3088\u3073\u7b4b\u9593\u30cb\u30e5\u30fc\u30ed\u30f3\u306b\u512a\u52e2\u3067\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u30aa\u30d4\u30aa\u30a4\u30c9\u53d7\u5bb9\u4f53\u306e\u6d3b\u6027\u5316\u306f\u3001GTP\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\uff08G\u30bf\u30f3\u30d1\u30af\u8cea\uff09\u3092\u4ecb\u3057\u305f\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001cAMP\u30ec\u30d9\u30eb\u306e\u4f4e\u4e0b\u3001\u96fb\u4f4d\u4f9d\u5b58\u6027\u30ab\u30eb\u30b7\u30a6\u30e0\u30c1\u30e3\u30cd\u30eb\uff08VGCC\uff09\u306e\u963b\u5bb3\u3001\u30ab\u30ea\u30a6\u30e0\u30a4\u30aa\u30f3\u30c1\u30e3\u30cd\u30eb\uff08GIRK\uff09\u306e\u958b\u653e\u3001\u304a\u3088\u3073\u30b7\u30ca\u30d7\u30b9\u5c0f\u80deSNAP\u53d7\u5bb9\u4f53\uff08SNARE\uff09\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\u306e\u6291\u5236\u306a\u3069\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">3.2 \u30aa\u30d4\u30aa\u30a4\u30c9\u306b\u3088\u308b\u8178\u7ba1\u904b\u52d5\u306e\u969c\u5bb3<\/h4>\n\n\n\n<p>\u30aa\u30d4\u30aa\u30a4\u30c9\u306f\u3001\u8178\u7ba1\u795e\u7d4c\u7cfb\u3001ICCs\u3001\u304a\u3088\u3073\u8178\u7ba1\u5e73\u6ed1\u7b4b\u7d30\u80de\u306b\u5b58\u5728\u3059\u308b\u30aa\u30d4\u30aa\u30a4\u30c9\u53d7\u5bb9\u4f53\u3092\u4ecb\u3057\u3066\u8178\u7ba1\u904b\u52d5\u3092\u6291\u5236\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">3.2.1 \u30aa\u30d4\u30aa\u30a4\u30c9\u306b\u3088\u308b\u8178\u7ba1\u795e\u7d4c\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u6291\u5236<\/h5>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u795e\u7d4c\u8208\u596e\u6027\u306e\u4f4e\u4e0b:<\/strong> \u30aa\u30d4\u30aa\u30a4\u30c9\uff08\u4e3b\u306bMOR\u3068DOR\uff09\u306f\u3001\u8178\u7ba1\u30cb\u30e5\u30fc\u30ed\u30f3\u4e0a\u306e\u6291\u5236\u6027G\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u7d50\u5408\u3057\u3001\u30a2\u30c7\u30cb\u30eb\u9178\u30b7\u30af\u30e9\u30fc\u30bc\uff08AC\uff09\u3092\u963b\u5bb3\u3057\u3001cAMP\u30ec\u30d9\u30eb\u3092\u4f4e\u4e0b\u3055\u305b\u3001\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bcA\uff08PKA\uff09\u306e\u6d3b\u6027\u3092\u6e1b\u5c11\u3055\u305b\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u8178\u7ba1\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u3086\u3063\u304f\u308a\u3068\u3057\u305f\u904e\u5206\u6975\uff08SAHP\uff09\u304c\u8d77\u3053\u308a\u3001\u795e\u7d4c\u8208\u596e\u6027\u304c\u4f4e\u4e0b\u3057\u3001\u795e\u7d4c\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u304c\u963b\u5bb3\u3055\u308c\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u653e\u51fa\u306e\u6e1b\u5c11:<\/strong> \u30aa\u30d4\u30aa\u30a4\u30c9\u53d7\u5bb9\u4f53\u306e\u6d3b\u6027\u5316\u306fVGCC\u306e\u6d3b\u52d5\u3092\u963b\u5bb3\u3057\u3001\u7d30\u80de\u5185Ca2+\u6fc3\u5ea6\u3068\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u306e\u653e\u51fa\u3092\u6e1b\u5c11\u3055\u305b\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u30a2\u30bb\u30c1\u30eb\u30b3\u30ea\u30f3\uff08Ash\uff09\u3084\u30bf\u30ad\u30ad\u30cb\u30f3\uff08\u30b5\u30d6\u30b9\u30bf\u30f3\u30b9P\uff09\u306a\u3069\u306e\u8208\u596e\u6027\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u304b\u3089\u306e\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u306e\u653e\u51fa\u304c\u59a8\u3052\u3089\u308c\u3001\u8178\u7ba1\u306e\u6a5f\u80fd\u3068\u4f1d\u9054\u304c\u59a8\u3052\u3089\u308c\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h5 class=\"wp-block-heading\">3.2.2 \u30aa\u30d4\u30aa\u30a4\u30c9\u306b\u3088\u308bKit+ICCs\u306e\u6e1b\u5c11<\/h5>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>ICCs\u306e\u91cd\u8981\u6027:<\/strong> ICCs\u306f\u8178\u7ba1\u904b\u52d5\u306e\u300c\u30da\u30fc\u30b9\u30e1\u30fc\u30ab\u30fc\u300d\u304a\u3088\u3073\u300c\u30e1\u30c8\u30ed\u30ce\u30fc\u30e0\u300d\u3068\u3057\u3066\u6a5f\u80fd\u3057\u3001\u8178\u7ba1\u306e\u5e73\u6ed1\u7b4b\u7d30\u80de\u3068\u306e\u6a4b\u6e21\u3057\u5f79\u3092\u679c\u305f\u3057\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>OIC\u306b\u304a\u3051\u308bICC\u306e\u67af\u6e07:<\/strong> \u300cOpioid-induced intestinal inflammation may mediate ICC depletion in OIC patients.\uff08\u30aa\u30d4\u30aa\u30a4\u30c9\u8a98\u767a\u6027\u306e\u8178\u7ba1\u708e\u75c7\u304cOIC\u60a3\u8005\u306b\u304a\u3051\u308bICC\u306e\u67af\u6e07\u3092\u5a92\u4ecb\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\uff09\u300d\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30e2\u30eb\u30d2\u30cd\u306b\u66dd\u9732\u3055\u308c\u305f\u4eba\u9593\u304a\u3088\u3073\u30de\u30a6\u30b9\u306e\u4fbf\u306e\u30aa\u30df\u30c3\u30af\u30b9\u89e3\u6790\u3067\u306f\u3001\u8178\u5185\u5fae\u751f\u7269\u53e2\u306e\u7d44\u6210\u306b\u8457\u3057\u3044\u5909\u5316\u304c\u898b\u3089\u308c\u3001\u30de\u30a6\u30b9\u306e\u4fbf\u30b5\u30f3\u30d7\u30eb\u3067\u306fLPS\u7523\u751f\u304c\u4e0a\u6607\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/li>\n\n\n\n<li><strong>\u30e1\u30ab\u30cb\u30ba\u30e0:<\/strong> LPS\/TLR4\/TNF-\u03b1\u7d4c\u8def\u304cKit\u3092\u4ecb\u3057\u305f\u7d30\u80de\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u963b\u5bb3\u3057\u3001ICCs\u306e\u5206\u5316\u3092\u59a8\u3052\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u3001M1\u6975\u6027\u5316\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u304b\u3089\u5206\u6ccc\u3055\u308c\u308b\u30a8\u30ad\u30bd\u30bd\u30fc\u30e0\u304c\u3001\u5e79\u7d30\u80de\u56e0\u5b50\uff08SCF\uff09\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u3067ICC\u306e\u91cf\u3068\u6a5f\u80fd\u3092\u8abf\u7bc0\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u8178\u5185\u5fae\u751f\u7269\u53e2\u306e\u8abf\u7bc0\uff08\u77ed\u9396\u8102\u80aa\u9178\uff08SCFA\uff09\u7523\u751f\u30845-\u30d2\u30c9\u30ed\u30ad\u30b7\u30c8\u30ea\u30d7\u30bf\u30df\u30f3\uff085-HT\uff09\u5206\u6ccc\u306e\u5897\u52a0\u3092\u4ecb\u3057\u3066\uff09\u304cICC\u96c6\u56e3\u3092\u56de\u5fa9\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h5 class=\"wp-block-heading\">3.2.3 \u30aa\u30d4\u30aa\u30a4\u30c9\u306b\u3088\u308b\u8178\u7ba1\u5e73\u6ed1\u7b4b\u306e\u4e0d\u898f\u5247\u306a\u53ce\u7e2e<\/h5>\n\n\n\n<p>\u8178\u7ba1\u5e73\u6ed1\u7b4b\u306f\u3001\u8208\u596e\u6027\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u3001\u6291\u5236\u6027\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u3001\u304a\u3088\u3073ICCs\u306b\u3088\u3063\u3066\u5236\u5fa1\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30aa\u30d4\u30aa\u30a4\u30c9\u306f\u3001\u795e\u7d4c\u8208\u596e\u6027\u306e\u4f4e\u4e0b\u3068ICCs\u306e\u6e1b\u5c11\u3092\u901a\u3058\u3066\u3001\u8178\u7ba1\u5e73\u6ed1\u7b4b\u306e\u8abf\u7bc0\u30b7\u30b9\u30c6\u30e0\u3092\u6a5f\u80fd\u4e0d\u5168\u306b\u3057\u3001OIC\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002\u30e2\u30eb\u30d2\u30cd\u306b\u66dd\u9732\u3055\u308c\u305f\u30de\u30a6\u30b9\u3067\u306f\u3001\u8fd1\u4f4d\u7d50\u8178\u3001\u56de\u8178\u3001\u7a7a\u8178\u3001\u7279\u306b\u76f4\u8178\u306e\u53ce\u7e2e\u6027\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u89b3\u5bdf\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">3.3 \u30aa\u30d4\u30aa\u30a4\u30c9\u306b\u3088\u308b\u8178\u5185\u5fae\u751f\u7269\u53e2\u306e\u4e0d\u5747\u8861\u3068\u30d0\u30ea\u30a2\u6a5f\u80fd\u4e0d\u5168<\/h4>\n\n\n\n<p>\u8907\u6570\u306e\u52d5\u7269\u7814\u7a76\u306b\u3088\u308a\u3001\u30aa\u30d4\u30aa\u30a4\u30c9\u304c\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u306e\u4e0d\u5747\u8861\u3001\u8178\u7c98\u819c\u30d0\u30ea\u30a2\u6a5f\u80fd\u4e0d\u5168\u3001\u304a\u3088\u3073\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u653e\u51fa\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">3.3.1 \u30aa\u30d4\u30aa\u30a4\u30c9\u306b\u3088\u308b\u8178\u5185\u5fae\u751f\u7269\u53e2\u7d44\u6210\u306e\u5909\u5316<\/h5>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u4e73\u9178\u83cc\u3068\u5acc\u6c17\u6027\u83cc\u306e\u6e1b\u5c11:<\/strong> \u81e8\u5e8a\u7814\u7a76\u3067\u306f\u3001\u30aa\u30d4\u30aa\u30a4\u30c9\u4f7f\u7528\u8005\u306b\u304a\u3044\u3066\u3001\u4e73\u9178\u83cc\u3068\u5acc\u6c17\u6027\u83cc\u306e\u5b58\u5728\u91cf\u304c\u6709\u610f\u306b\u5909\u5316\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u8178\u7ba1\u904b\u52d5\u8abf\u7bc0\u3078\u306e\u5f71\u97ff:<\/strong> \u300cIt is plausible to infer that opioids may decrease intestinal SCFA concentrations to repress 5-HT3 receptor activity, ultimately contributing to intestinal dysbiosis.\uff08\u30aa\u30d4\u30aa\u30a4\u30c9\u306f\u8178\u5185SCFA\u6fc3\u5ea6\u3092\u4f4e\u4e0b\u3055\u305b\u30015-HT3\u53d7\u5bb9\u4f53\u6d3b\u6027\u3092\u6291\u5236\u3057\u3001\u6700\u7d42\u7684\u306b\u8178\u5185\u7d30\u83cc\u53e2\u306e\u4e0d\u5747\u8861\u306b\u5bc4\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u63a8\u8ad6\u3059\u308b\u306e\u304c\u59a5\u5f53\u3067\u3042\u308b\uff09\u300d\u3053\u3068\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u8178\u5185\u7d30\u83cc\u7531\u6765\u306e\u4ee3\u8b1d\u7523\u7269\u3067\u3042\u308b\u77ed\u9396\u8102\u80aa\u9178\uff08SCFA\uff09\u306f\u3001\u8ff7\u8d70\u795e\u7d4c\u6c42\u5fc3\u6027\u7dda\u7dad\u4e0a\u306e5-HT3\u53d7\u5bb9\u4f53\u3092\u523a\u6fc0\u3059\u308b\u3053\u3068\u3067\u8178\u7ba1\u904b\u52d5\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h5 class=\"wp-block-heading\">3.3.2 \u30aa\u30d4\u30aa\u30a4\u30c9\u306b\u3088\u308b\u8178\u7ba1\u30d0\u30ea\u30a2\u6a5f\u80fd\u306e\u969c\u5bb3<\/h5>\n\n\n\n<p>\u8178\u7ba1\u30d0\u30ea\u30a2\u306f\u3001\u7c98\u6db2\u3001\u8178\u5185\u5fae\u751f\u7269\u3001\u9632\u5fa1\u30bf\u30f3\u30d1\u30af\u8cea\u3001\u8178\u7ba1\u4e0a\u76ae\u7d30\u80de\u3001\u514d\u75ab\u7d30\u80de\u304b\u3089\u69cb\u6210\u3055\u308c\u3001\u305d\u306e\u969c\u5bb3\u306f\u8178\u6a5f\u80fd\u4e0d\u5168\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30bf\u30a4\u30c8\u30b8\u30e3\u30f3\u30af\u30b7\u30e7\u30f3\u306e\u6e1b\u5c11\u3068\u676f\u7d30\u80de\u306e\u6e1b\u5c11:<\/strong> \u30e2\u30eb\u30d2\u30cd\u306b\u66dd\u9732\u3055\u308c\u305f\u30de\u30a6\u30b9\u3067\u306f\u3001\u8178\u7ba1\u4e0a\u76ae\u7d30\u80de\u9593\u306e\u30bf\u30a4\u30c8\u30b8\u30e3\u30f3\u30af\u30b7\u30e7\u30f3\u304c\u6e1b\u5c11\u3057\u3001\u676f\u7d30\u80de\u306e\u96c6\u56e3\u304c\u6e1b\u5c11\u3057\u3001\u514d\u75ab\u5fdc\u7b54\u304c\u6e1b\u5f31\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u30aa\u30d4\u30aa\u30a4\u30c9\u4f7f\u7528\u304c\u8178\u7ba1\u30d0\u30ea\u30a2\u6a5f\u80fd\u306e\u72ec\u7acb\u3057\u305f\u5371\u967a\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>Akkermansia muciniphila\u306e\u6e1b\u5c11:<\/strong> \u9577\u671f\u30e1\u30b5\u30c9\u30f3\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308b\u60a3\u8005\u3067\u306f\u3001\u8178\u7ba1\u4e0a\u76ae\u306e\u5b8c\u5168\u6027\u306e\u4f4e\u4e0b\u3068\u3001Akkermansia muciniphila\u306e\u5b58\u5728\u91cf\u306e\u6e1b\u5c11\u304c\u89b3\u5bdf\u3055\u308c\u3066\u3044\u307e\u3059\u3002Akkermansia muciniphila\u306f\u3001\u8178\u7ba1\u514d\u75ab\u3001\u795e\u7d4c\u5fdc\u7b54\u3001\u304a\u3088\u3073\u4ee3\u8b1d\u3092\u5f37\u5316\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u6709\u76ca\u306a\u52b9\u679c\u3092\u767a\u63ee\u3057\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>Notch\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u306e\u6291\u5236:<\/strong> \u8178\u7ba1\u4e0a\u76ae\u7d30\u80de\u306e\u7dad\u6301\u306f\u3001\u9670\u7aa9\u5e79\u7d30\u80de\u306e\u5206\u5316\u306b\u4f9d\u5b58\u3057\u3066\u3044\u307e\u3059\u3002\u30e2\u30eb\u30d2\u30cd\u66dd\u9732\u306f\u3001\u9670\u7aa9\u5e79\u7d30\u80de\u306e\u5206\u5316\u3068\u5897\u6b96\u306b\u91cd\u8981\u306aNotch\u7d4c\u8def\u3092\u6709\u610f\u306b\u6291\u5236\u3057\u3001\u9670\u7aa9\u5e79\u7d30\u80de\u306e\u6570\u3092\u3055\u3089\u306b\u6e1b\u5c11\u3055\u305b\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u7c98\u6db2\u5206\u6ccc\u306e\u6e1b\u5c11:<\/strong> \u30aa\u30d4\u30aa\u30a4\u30c9\u306f\u3001\u8178\u7ba1\u904b\u52d5\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3067\u8178\u7ba1\u5185\u5bb9\u7269\u306e\u901a\u904e\u3092\u9045\u3089\u305b\u3001\u7c98\u6db2\u5206\u6ccc\u3092\u6e1b\u5c11\u3055\u305b\u307e\u3059\u3002\u9577\u671f\u9593\u306e\u30aa\u30d4\u30aa\u30a4\u30c9\u4f7f\u7528\u306f\u3001\u7c98\u6db2\u5c64\u306e\u7d44\u6210\u3068\u6c34\u5206\u542b\u6709\u91cf\u3092\u7834\u58ca\u3057\u3001\u300c\u7de9\u885d\u5e2f\u300d\u304a\u3088\u3073\u300c\u4fdd\u8b77\u5c64\u300d\u3068\u3057\u3066\u306e\u7c98\u6db2\u5c64\u306e\u5f79\u5272\u3092\u596a\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h5 class=\"wp-block-heading\">3.3.3 \u8178\u7ba1\u514d\u75ab\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3068\u708e\u75c7<\/h5>\n\n\n\n<p>\u4fbf\u79d8\u5f8c\u306b\u306f\u8178\u7ba1\u514d\u75ab\u7d30\u80de\u304c\u6d3b\u6027\u5316\u3055\u308c\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u304a\u308a\u3001\u8178\u7ba1\u514d\u75ab\u7cfb\u3068\u8178\u7ba1\u795e\u7d4c\u7cfb\u306e\u9593\u306e\u76f8\u4e92\u4f5c\u7528\u306f\u8178\u7ba1\u6052\u5e38\u6027\u306e\u7dad\u6301\u306b\u4e0d\u53ef\u6b20\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u514d\u75ab\u6291\u5236\u3068\u708e\u75c7\u4fc3\u9032:<\/strong> MOR\u4f5c\u52d5\u85ac\u306f\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3068\u5358\u7403\u306eLPS\u306b\u5bfe\u3059\u308b\u514d\u75ab\u5fdc\u7b54\u3092\u6291\u5236\u3057\u3001NK\u7d30\u80de\u306e\u7d30\u80de\u6bd2\u6027\u3092\u6e1b\u5c11\u3055\u305b\u3001\u8178\u7ba1\u708e\u75c7\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u306e\u5909\u5316:<\/strong> \u77ed\u671f\u307e\u305f\u306f\u9577\u671f\u306e\u30e2\u30eb\u30d2\u30cd\u6cbb\u7642\u3092\u53d7\u3051\u305f\u60a3\u8005\u3067\u306f\u3001\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u306e\u7d44\u6210\u304c\u5909\u5316\u3057\u3001\u4e3b\u306b\u30d0\u30af\u30c6\u30ed\u30a4\u30c7\u30b9\u9580\u3068\u30d5\u30a1\u30fc\u30df\u30ad\u30e5\u30fc\u30c6\u30b9\u9580\u304c\u6e1b\u5c11\u3057\u3001\u30d7\u30ed\u30c6\u30aa\u30d0\u30af\u30c6\u30ea\u30a2\u304c\u5897\u52a0\u3057\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>Treg\u7d30\u80de\u3068SCFA\u306e\u95a2\u9023:<\/strong> \u5236\u5fa1\u6027T\u7d30\u80de\uff08Tregs\uff09\u306f\u8178\u7ba1\u7d30\u80de\u306b\u304a\u3051\u308b\u30aa\u30d4\u30aa\u30a4\u30c9\u53d7\u5bb9\u4f53\u306e\u767a\u73fe\u3092\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u3067\u8178\u7ba1\u708e\u75c7\u3092\u6291\u5236\u3057\u3001\u8178\u7ba1\u904b\u52d5\u8abf\u7bc0\u7570\u5e38\u3092\u662f\u6b63\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002Treg\u306e\u767a\u751f\u3068\u6a5f\u80fd\u306f\u8178\u5185\u5fae\u751f\u7269\u4ee3\u8b1d\u7523\u7269SCFA\u306e\u7523\u751f\u306b\u4f9d\u5b58\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u30e2\u30eb\u30d2\u30cd\u6cbb\u7642\u5f8c\u306b\u306fSCFA\u306e\u7523\u751f\u304c\u6e1b\u5c11\u3057\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u6a5f\u80fd\u306e\u969c\u5bb3:<\/strong> \u30aa\u30d4\u30aa\u30a4\u30c9\u306f\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u8a98\u5c0e\u3057\u3001\u8caa\u98df\u4f5c\u7528\u3092\u6e1b\u5c11\u3055\u305b\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306e\u88dc\u5145\u3092\u963b\u5bb3\u3057\u3001\u305d\u308c\u306b\u3088\u3063\u3066\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306e\u514d\u75ab\u6a5f\u80fd\u3092\u969c\u5bb3\u3057\u3001\u8178\u7ba1\u708e\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">3.4 \u30aa\u30d4\u30aa\u30a4\u30c9\u306b\u3088\u308b\u8178\u7ba1\u30b0\u30ea\u30a2\u7d30\u80de\uff08EGCs\uff09\u306e\u9593\u63a5\u7684\u306a\u8abf\u7bc0<\/h4>\n\n\n\n<p>\u30e2\u30eb\u30d2\u30cd\u306f\u3001EGCs\u306b\u304a\u3051\u308b\u30b0\u30ea\u30a2\u7dda\u7dad\u6027\u9178\u6027\u30bf\u30f3\u30d1\u30af\u8cea\uff08GFAP\uff09\u306e\u767a\u73fe\u3068\u708e\u75c7\u6027\u56e0\u5b50\u306e\u5206\u6ccc\u3092\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u3067OIC\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>MOR\u306e\u95a2\u4e0e:<\/strong> MOR\u907a\u4f1d\u5b50\u3092siRNA\u3067\u30b5\u30a4\u30ec\u30f3\u30b7\u30f3\u30b0\u3059\u308b\u3053\u3068\u3067\u3053\u306e\u52b9\u679c\u306f\u9006\u8ee2\u3059\u308b\u305f\u3081\u3001OIC\u306e\u767a\u75c7\u306bMOR\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>ATP\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3068\u795e\u7d4c\u7d30\u80de\u6b7b:<\/strong> \u30e2\u30eb\u30d2\u30cd\u306b\u66dd\u9732\u3055\u308c\u305f\u30de\u30a6\u30b9\u306e\u8178\u7ba1EGCs\u3067\u306f\u3001\u30d7\u30ea\u30f3\u4f5c\u52d5\u6027P2X\u53d7\u5bb9\u4f53\u6d3b\u6027\u304c\u8457\u3057\u304f\u4ea2\u9032\u3057\u3001LPS\u306f\u3055\u3089\u306bATP\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u5897\u5e45\u3055\u305b\u3001P2X4\/7\u53d7\u5bb9\u4f53\u306e\u767a\u73fe\u3092\u5f37\u5316\u3057\u307e\u3059\u3002ATP\u306f\u3001EGCs-\u30d7\u30ea\u30f3\u4f5c\u52d5\u6027-\u30b3\u30cd\u30ad\u30b7\u30f343\uff08CX43\uff09\u7d4c\u8def\u3092\u4ecb\u3057\u3066\u8178\u7ba1\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u6b7b\u3092\u8a98\u5c0e\u3057\u3001\u8178\u7ba1\u904b\u52d5\u3092\u969c\u5bb3\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>CMMC\u6a5f\u80fd\u3078\u306e\u5f71\u97ff:<\/strong> \u7d50\u8178\u306e\u7cde\u4fbf\u3092\u63a8\u9032\u3059\u308b\u7d50\u8178\u79fb\u884c\u6027\u904b\u52d5\u8907\u5408\u4f53\uff08CMMC\uff09\u306f\u3001\u4e3b\u306b\u8208\u596e\u6027\u30b3\u30ea\u30f3\u4f5c\u52d5\u6027\u30cb\u30e5\u30fc\u30ed\u30f3\u306b\u3088\u3063\u3066\u99c6\u52d5\u3055\u308c\u3001EGCs\u304c\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002NO\/cGMP\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306fCMMC\u6a5f\u80fd\u306b\u4e0d\u53ef\u6b20\u3067\u3042\u308a\u3001MOR\u306e\u6d3b\u6027\u5316\u306f\u8178\u7ba1\u708e\u75c7\u3092\u8a98\u5c0e\u3057\u3001\u8178\u7ba1\u795e\u7d4c\u7d30\u80de\u306b\u640d\u50b7\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">4. \u8003\u5bdf\u3068\u6f5c\u5728\u7684\u306a\u6cbb\u7642\u6a19\u7684<\/h3>\n\n\n\n<p>OIC\u306f\u3001\u30aa\u30d4\u30aa\u30a4\u30c9\u93ae\u75db\u5264\u3092\u6295\u4e0e\u3055\u308c\u3066\u3044\u308b\u304c\u3093\u60a3\u8005\u306e\u4e00\u822c\u7684\u306a\u5408\u4f75\u75c7\u3067\u3042\u308a\u3001\u60a3\u8005\u306e\u7d4c\u6e08\u72b6\u6cc1\u3068\u751f\u6d3b\u306e\u8cea\u306b\u5927\u304d\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u73fe\u5728\u306e\u6cbb\u7642\u9078\u629e\u80a2\u306f\u6700\u9069\u3068\u306f\u8a00\u3048\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>OIC\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u307e\u3068\u3081:<\/strong> \u30aa\u30d4\u30aa\u30a4\u30c9\u306f\u3001\u8178\u7ba1\u904b\u52d5\u795e\u7d4c\u3068ICCs\u3092\u969c\u5bb3\u3057\u3066\u80c3\u8178\u904b\u52d5\u3092\u4f4e\u4e0b\u3055\u305b\u307e\u3059\u3002\u305d\u306e\u5f8c\u306e\u8178\u5185\u5fae\u751f\u7269\u53e2\u3068\u8178\u7ba1\u30d0\u30ea\u30a2\u6a5f\u80fd\u306e\u969c\u5bb3\u304c\u708e\u75c7\u3068\u80c3\u8178\u904b\u52d5\u969c\u5bb3\u3092\u60aa\u5316\u3055\u305b\u3001\u6700\u7d42\u7684\u306bOIC\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u8178\u5185\u5fae\u751f\u7269\u53e2\u306e\u5f79\u5272:<\/strong> \u300cThe gut microbiota and their metabolites co-work in the pathogenesis of OIC.\uff08\u8178\u5185\u5fae\u751f\u7269\u53e2\u3068\u305d\u306e\u4ee3\u8b1d\u7523\u7269\u306f\u3001OIC\u306e\u75c5\u614b\u767a\u751f\u306b\u304a\u3044\u3066\u5171\u540c\u3067\u4f5c\u7528\u3059\u308b\uff09\u300d\u3053\u3068\u304c\u5f37\u8abf\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>ICCs\u306e\u91cd\u8981\u6027:<\/strong> \u300cThe reduction in the number of ICCs, which act as the \u201cpacemakers\u201d of gastrointestinal motility, may serve as a mechanism of OIC.\uff08\u80c3\u8178\u904b\u52d5\u306e\u300c\u30da\u30fc\u30b9\u30e1\u30fc\u30ab\u30fc\u300d\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308bICCs\u306e\u6570\u306e\u6e1b\u5c11\u306f\u3001OIC\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\uff09\u300d\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u8178\u7ba1\u6052\u5e38\u6027\u306b\u304a\u3051\u308b\u76f8\u4e92\u4f5c\u7528:<\/strong> \u8178\u5185\u7d30\u83cc\u3068\u8178\u7ba1\u795e\u7d4c\u7cfb\u306e\u9593\u306e\u76f8\u4e92\u4f5c\u7528\u306f\u8178\u7ba1\u6052\u5e38\u6027\u306e\u7dad\u6301\u306b\u4e0d\u53ef\u6b20\u3067\u3042\u308a\u3001SCFA\u306f\u8178\u7ba1\u514d\u75ab\u7d30\u80de\u306b\u3068\u3063\u3066\u91cd\u8981\u3067\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u8178\u5185\u5fae\u751f\u7269\u53e2\u306e\u5909\u5316\u306f\u8178\u7ba1\u514d\u75ab\u7cfb\u306e\u8abf\u7bc0\u4e0d\u5168\u306b\u5bc4\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u7d50\u8ad6\u3068\u3057\u3066\u3001\u8178\u5185\u5fae\u751f\u7269\u53e2\u3068\u305d\u306e\u4ee3\u8b1d\u7523\u7269\u306fOIC\u306e\u75c5\u614b\u5f62\u6210\u306b\u304a\u3044\u3066\u6975\u3081\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u304a\u308a\u3001\u6cbb\u7642\u6a19\u7684\u3068\u3057\u3066\u306e\u5927\u304d\u306a\u53ef\u80fd\u6027\u3092\u79d8\u3081\u3066\u3044\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<p>&#8212;<\/p>\n\n\n\n<p>\u539f\u8457\u306e\u30ea\u30f3\u30af\uff1a<\/p>\n\n\n\n<p><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.70553\">https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.70553<\/a><\/p>\n\n\n\n<p>\u30e9\u30a4\u30bb\u30f3\u30b9\uff1a<\/p>\n\n\n\n<p>CC-BY 4.0<\/p>\n\n\n\n<p><a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\">https:\/\/creativecommons.org\/licenses\/by\/4.0<\/a><\/p>\n\n\n\n<p>\u66f8\u8a8c\u4e8b\u9805\uff1a<\/p>\n\n\n\n<p>Liu M, Sheng Y, He Y, Wu S, Jin C, Shen L. <strong>Progresses in Questing for the Truth of Opioid-Related Constipation in Cancer Patients<\/strong>. Journal of Cellular and Molecular Medicine. 2025;29:e70553.<\/p>\n\n\n\n<p>\u6539\u5909\u3068\u9650\u754c\uff1a<\/p>\n\n\n\n<p>\u672c\u30b3\u30f3\u30c6\u30f3\u30c4\u306f\u53c2\u7167\u3057\u305f\u8ad6\u6587\u306e\u5185\u5bb9\u306b\u57fa\u3065\u3044\u3066\u3001\u751f\u6210AI\u306b\u3088\u308a\u305d\u306e\u5185\u5bb9\u3092\u307e\u3068\u3081\u306a\u304a\u3057\u305f\u3082\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p>AI\u306e\u9650\u754c\u3068\u3057\u3066\u30cf\u30eb\u30b7\u30cd\u30fc\u30b7\u30e7\u30f3\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u6f22\u5b57\u306e\u8aad\u307f\u9593\u9055\u3044\u304c\u5b58\u5728\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-audio\"><audio controls src=\"https:\/\/plaza.umin.ac.jp\/~OIO\/s2d\/wp-content\/uploads\/sites\/3\/2025\/09\/a04be2a73fc89ee2f8ff54ea8545e41e.mp3\"><\/audio><\/figure>\n\n\n\n<p><\/p>\n<div class=\"powerpress_player\" id=\"powerpress_player_4816\"><audio class=\"wp-audio-shortcode\" id=\"audio-1947-1\" preload=\"none\" style=\"width: 100%;\" controls=\"controls\"><source type=\"audio\/mpeg\" src=\"https:\/\/media.blubrry.com\/3954323\/plaza.umin.ac.jp\/~OIO\/s2d\/wp-content\/uploads\/sites\/3\/2025\/09\/a04be2a73fc89ee2f8ff54ea8545e41e.mp3?_=1\" \/><a href=\"https:\/\/media.blubrry.com\/3954323\/plaza.umin.ac.jp\/~OIO\/s2d\/wp-content\/uploads\/sites\/3\/2025\/09\/a04be2a73fc89ee2f8ff54ea8545e41e.mp3\">https:\/\/media.blubrry.com\/3954323\/plaza.umin.ac.jp\/~OIO\/s2d\/wp-content\/uploads\/sites\/3\/2025\/09\/a04be2a73fc89ee2f8ff54ea8545e41e.mp3<\/a><\/audio><\/div><p class=\"powerpress_links powerpress_links_mp3\" style=\"margin-bottom: 1px !important;\">Podcast: <a href=\"https:\/\/media.blubrry.com\/3954323\/plaza.umin.ac.jp\/~OIO\/s2d\/wp-content\/uploads\/sites\/3\/2025\/09\/a04be2a73fc89ee2f8ff54ea8545e41e.mp3\" class=\"powerpress_link_pinw\" target=\"_blank\" title=\"Play in new window\" onclick=\"return powerpress_pinw('https:\/\/plaza.umin.ac.jp\/~OIO\/s2d\/?powerpress_pinw=1947-podcast');\" rel=\"nofollow\">Play in new window<\/a> | <a href=\"https:\/\/media.blubrry.com\/3954323\/plaza.umin.ac.jp\/~OIO\/s2d\/wp-content\/uploads\/sites\/3\/2025\/09\/a04be2a73fc89ee2f8ff54ea8545e41e.mp3\" class=\"powerpress_link_d\" title=\"Download\" rel=\"nofollow\" download=\"a04be2a73fc89ee2f8ff54ea8545e41e.mp3\">Download<\/a><\/p><!--powerpress_player-->","protected":false},"excerpt":{"rendered":"<p>\u304c\u3093\u60a3\u8005\u306b\u304a\u3051\u308b\u30aa\u30d4\u30aa\u30a4\u30c9\u8a98\u767a\u6027\u4fbf\u79d8\uff08OIC\uff09\u306e\u4e3b\u8981\u30c6\u30fc\u30de\u3068\u91cd\u8981\u306a\u4e8b\u5b9f\u306b\u95a2\u3059\u308b\u8a73\u7d30\u306a\u8aac\u660e\u8cc7\u6599 1. \u306f\u3058\u3081\u306b \u30aa\u30d4\u30aa\u30a4\u30c9\u8a98\u767a\u6027\u4fbf\u79d8\uff08OIC\uff09\u306f\u3001\u304c\u3093\u60a3\u8005\u306e\u75bc\u75db\u7ba1\u7406\u306b\u5e83\u304f\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u30aa\u30d4\u30aa\u30a4\u30c9\u306e\u4e00\u822c\u7684\u306a\u5408\u4f75\u75c7\u3067\u3042\u308a\u3001\u60a3\u8005\u306e\u4e88\u5f8c\u3068\u751f\u6d3b\u306e\u8cea\u306b\u8457\u3057\u3044\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002OIC\u306e\u75c5\u614b\u306f\u8907\u96d1\u3067\u3042\u308a\u3001\u52b9\u679c\u7684\u306a\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u3092\u56f0\u96e3\u306b\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u8aac\u660e\u8cc7\u6599\u306f\u3001\u63d0\u4f9b\u3055\u308c\u305f\u60c5\u5831\u6e90\u306b\u57fa\u3065\u3044\u3066\u3001OIC\u306e\u4e3b\u8981\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u6f5c\u5728\u7684\u306a\u6cbb\u7642\u6a19\u7684\u3092\u5305\u62ec\u7684\u306b\u30ec\u30d3\u30e5\u30fc\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3066\u3044\u307e\u3059\u3002 2. OIC\u306e\u5b9a\u7fa9\u3068\u8a3a\u65ad\u57fa\u6e96 OIC\u306f\u4ee5\u524d\u3001\u30aa\u30d4\u30aa\u30a4\u30c9\u8a98\u767a\u6027\u8178\u6a5f\u80fd\u969c\u5bb3\uff08OIBD\uff09\u306e\u4e00\u75c7\u72b6\u3068\u898b\u306a\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u73fe\u5728\u3067\u306f\u3001\u80c3\u8178\u79d1\u533b\u3001\u816b\u760d\u79d1\u533b\u3001\u8001\u5e74\u79d1\u533b\u3001\u75bc\u75db\u5c02\u9580\u533b\u306b\u3088\u308b\u5b66\u969b\u7684\u306a\u7ba1\u7406\u304c\u5fc5\u8981\u306a\u72ec\u7acb\u3057\u305f\u75be\u60a3\u3068\u3057\u3066\u8a8d\u8b58\u3055\u308c\u3066\u3044\u307e\u3059\u3002 3. OIC\u306e\u75c5\u614b\u30e1\u30ab\u30cb\u30ba\u30e0 OIC\u306f\u3001\u30aa\u30d4\u30aa\u30a4\u30c9\u304c\u8178\u7ba1\u306e\u8907\u6570\u306e\u5074\u9762\u306b\u4f5c\u7528\u3059\u308b\u591a\u56e0\u5b50\u6027\u306e\u30d7\u30ed\u30bb\u30b9\u3067\u3059\u3002\u4e3b\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3059\u3002 3.1 \u30aa\u30d4\u30aa\u30a4\u30c9\u53d7\u5bb9\u4f53\u306e\u4f5c\u7528 \u30aa\u30d4\u30aa\u30a4\u30c9\u306f\u3001\u30e2\u30eb\u30d2\u30cd\u53d7\u5bb9\u4f53\uff08MOR\uff09\u3001\u30c7\u30eb\u30bf\u30aa\u30d4\u30aa\u30a4\u30c9\u53d7\u5bb9\u4f53\uff08DOR\uff09\u3001\u30ab\u30c3\u30d1\u30aa\u30d4\u30aa\u30a4\u30c9\u53d7\u5bb9\u4f53\uff08KOR\uff09\u3001\u30ce\u30b7\u30bb\u30d7\u30c1\u30f3\u53d7\u5bb9\u4f53\uff08NOPR\uff09\u3001MRGPRX1\u3001MRGPRX2\u306a\u3069\u306e\u30aa\u30d4\u30aa\u30a4\u30c9\u30ea\u30ac\u30f3\u30c9\u7d50\u5408\u3092\u4ecb\u3057\u3066\u4f5c\u7528\u3057\u307e\u3059\u3002\u8178\u7ba1\u306b\u306f\u3059\u3079\u3066\u306e\u30aa\u30d4\u30aa\u30a4\u30c9\u53d7\u5bb9\u4f53\u30b5\u30d6\u30bf\u30a4\u30d7\u304c\u5b58\u5728\u3057\u3001\u4e2d\u3067\u3082MOR\u304c\u6700\u3082\u8c4a\u5bcc\u3067\u3059\u3002 \u30aa\u30d4\u30aa\u30a4\u30c9\u53d7\u5bb9\u4f53\u306e\u6d3b\u6027\u5316\u306f\u3001GTP\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\uff08G\u30bf\u30f3\u30d1\u30af\u8cea\uff09\u3092\u4ecb\u3057\u305f\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001cAMP\u30ec\u30d9\u30eb\u306e\u4f4e\u4e0b\u3001\u96fb\u4f4d\u4f9d\u5b58\u6027\u30ab\u30eb\u30b7\u30a6\u30e0\u30c1\u30e3\u30cd\u30eb\uff08VGCC\uff09\u306e\u963b\u5bb3\u3001\u30ab\u30ea\u30a6\u30e0\u30a4\u30aa\u30f3\u30c1\u30e3\u30cd\u30eb\uff08GIRK\uff09\u306e\u958b\u653e\u3001\u304a\u3088\u3073\u30b7\u30ca\u30d7\u30b9\u5c0f\u80deSNAP\u53d7\u5bb9\u4f53\uff08SNARE\uff09\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\u306e\u6291\u5236\u306a\u3069\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002 3.2 \u30aa\u30d4\u30aa\u30a4\u30c9\u306b\u3088\u308b\u8178\u7ba1\u904b\u52d5\u306e\u969c\u5bb3 \u30aa\u30d4\u30aa\u30a4\u30c9\u306f\u3001\u8178\u7ba1\u795e\u7d4c\u7cfb\u3001ICCs\u3001\u304a\u3088\u3073\u8178\u7ba1\u5e73\u6ed1\u7b4b\u7d30\u80de\u306b\u5b58\u5728\u3059\u308b\u30aa\u30d4\u30aa\u30a4\u30c9\u53d7\u5bb9\u4f53\u3092\u4ecb\u3057\u3066\u8178\u7ba1\u904b\u52d5\u3092\u6291\u5236\u3057\u307e\u3059\u3002 3.2.1 \u30aa\u30d4\u30aa\u30a4\u30c9\u306b\u3088\u308b\u8178\u7ba1\u795e\u7d4c\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u6291\u5236 3.2.2 \u30aa\u30d4\u30aa\u30a4\u30c9\u306b\u3088\u308bKit+ICCs\u306e\u6e1b\u5c11 3.2.3 \u30aa\u30d4\u30aa\u30a4\u30c9\u306b\u3088\u308b\u8178\u7ba1\u5e73\u6ed1\u7b4b\u306e\u4e0d\u898f\u5247\u306a\u53ce\u7e2e \u8178\u7ba1\u5e73\u6ed1\u7b4b\u306f\u3001\u8208\u596e\u6027\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u3001\u6291\u5236\u6027\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u3001\u304a\u3088\u3073ICCs\u306b\u3088\u3063\u3066\u5236\u5fa1\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30aa\u30d4\u30aa\u30a4\u30c9\u306f\u3001\u795e\u7d4c\u8208\u596e\u6027\u306e\u4f4e\u4e0b\u3068ICCs\u306e\u6e1b\u5c11\u3092\u901a\u3058\u3066\u3001\u8178\u7ba1\u5e73\u6ed1\u7b4b\u306e\u8abf\u7bc0\u30b7\u30b9\u30c6\u30e0\u3092\u6a5f\u80fd\u4e0d\u5168\u306b\u3057\u3001OIC\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002\u30e2\u30eb\u30d2\u30cd\u306b\u66dd\u9732\u3055\u308c\u305f\u30de\u30a6\u30b9\u3067\u306f\u3001\u8fd1\u4f4d\u7d50\u8178\u3001\u56de\u8178\u3001\u7a7a\u8178\u3001\u7279\u306b\u76f4\u8178\u306e\u53ce\u7e2e\u6027\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u89b3\u5bdf\u3055\u308c\u3066\u3044\u307e\u3059\u3002 3.3 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Progresses in Questing for the Truth of Opioid-Related Constipation in Cancer Patients. 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