{"id":1887,"date":"2025-07-29T09:10:19","date_gmt":"2025-07-29T00:10:19","guid":{"rendered":"https:\/\/plaza.umin.ac.jp\/~OIO\/s2d\/?p=1887"},"modified":"2025-07-29T10:07:12","modified_gmt":"2025-07-29T01:07:12","slug":"%e3%81%aa%e3%81%9c%e5%8a%b9%e3%81%8b%e3%81%aa%e3%81%84%ef%bc%9f%e6%b2%bb%e7%99%82%e6%8a%b5%e6%8a%97%e6%80%a7%e3%81%86%e3%81%a4%e7%97%85%e3%81%ae%e8%ac%8e%e3%81%a8%e6%9c%80%e6%96%b0%e6%b2%bb%e7%99%82","status":"publish","type":"post","link":"https:\/\/plaza.umin.ac.jp\/~OIO\/s2d\/2025\/07\/29\/%e3%81%aa%e3%81%9c%e5%8a%b9%e3%81%8b%e3%81%aa%e3%81%84%ef%bc%9f%e6%b2%bb%e7%99%82%e6%8a%b5%e6%8a%97%e6%80%a7%e3%81%86%e3%81%a4%e7%97%85%e3%81%ae%e8%ac%8e%e3%81%a8%e6%9c%80%e6%96%b0%e6%b2%bb%e7%99%82\/","title":{"rendered":"\u306a\u305c\u52b9\u304b\u306a\u3044\uff1f\u6cbb\u7642\u62b5\u6297\u6027\u3046\u3064\u75c5\u306e\u8b0e\u3068\u6700\u65b0\u6cbb\u7642\u306e\u30d5\u30ed\u30f3\u30c6\u30a3\u30a2"},"content":{"rendered":"\n<p>\u8a18\u4e8b\u306e\u6982\u8981\u3067\u3059<\/p>\n\n\n\n<p><a href=\"https:\/\/link.springer.com\/article\/10.1186\/s43556-024-00205-y\"><\/a><a href=\"https:\/\/link.springer.com\/article\/10.1186\/s43556-024-00205-y\">\u300cTreatment-resistant depression: molecular mechanisms and management(\u6cbb\u7642\u62b5\u6297\u6027\u3046\u3064\u75c5\uff1a\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u7ba1\u7406)\u300d<\/a>\u3068\u984c\u3055\u308c\u305f\u3053\u306e\u6587\u66f8\u306f\u3001\u3046\u3064\u75c5\u3001\u7279\u306b\u6cbb\u7642\u62b5\u6297\u6027\u3046\u3064\u75c5\uff08TRD\uff09\u306b\u95a2\u3059\u308b\u7406\u89e3\u3092\u30ec\u30d3\u30e5\u30fc\u3057\u3066\u3044\u307e\u3059\u3002\u3046\u3064\u75c5\u304c\u975e\u5e38\u306b\u4e0d\u5747\u4e00\u3067\u3042\u308a\u3001\u500b\u4eba\u9593\u3067\u57fa\u790e\u3068\u306a\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u591a\u69d8\u3067\u3042\u308b\u3053\u3068\u3001\u307e\u305f\u73fe\u5728\u306e\u7b2c\u4e00\u9078\u629e\u85ac\u3067\u3042\u308b\u6297\u3046\u3064\u85ac\u304c\u60a3\u8005\u306e\u307b\u307c66%\u306b\u52b9\u679c\u304c\u306a\u3044\u3053\u3068\u3092\u5f37\u8abf\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4e3b\u306a\u767a\u898b\u3068\u8b70\u8ad6\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u8907\u96d1\u306a\u30e1\u30ab\u30cb\u30ba\u30e0<\/strong>: \u3046\u3064\u75c5\u306e\u75c5\u56e0\u3068\u6297\u3046\u3064\u85ac\u53cd\u5fdc\u306b\u306f\u3001\u69d8\u3005\u306a\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u30b7\u30b9\u30c6\u30e0\uff08\u30bb\u30ed\u30c8\u30cb\u30f3\u3001\u30c9\u30fc\u30d1\u30df\u30f3\u3001\u30ce\u30eb\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\u306a\u3069\uff09\u3001\u708e\u75c7\u6027\u30e1\u30c7\u30a3\u30a8\u30fc\u30bf\u30fc\u3001\u30b9\u30c8\u30ec\u30b9\u3001HPA\u8ef8\u306e\u6a5f\u80fd\u4e0d\u5168\u3001\u907a\u4f1d\u3001\u7cbe\u795e\u795e\u7d4c\u751f\u7406\u5b66\u7684\u8981\u56e0\u306e\u76f8\u4e92\u4f5c\u7528\u304c\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u73fe\u5728\u306e\u6cbb\u7642\u6cd5\u306e\u9650\u754c<\/strong>: \u30e2\u30ce\u30a2\u30df\u30f3\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u304c\u591a\u3044\u5f93\u6765\u306e\u6297\u3046\u3064\u85ac\u306f\u3001\u5927\u591a\u6570\u306e\u60a3\u8005\u306b\u52b9\u679c\u304c\u306a\u304f\u3001\u8a66\u884c\u932f\u8aa4\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u4e00\u822c\u7684\u3067\u3059\u3002\u6cbb\u7642\u52b9\u679c\u306e\u767a\u73fe\u304c\u9045\u3044\u3053\u3068\u3084\u3001\u500b\u3005\u306e\u53cd\u5fdc\u304c\u7570\u306a\u308b\u3053\u3068\u3082\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u6cbb\u7642\u62b5\u6297\u6027\u3046\u3064\u75c5\uff08TRD\uff09<\/strong>: TRD\u306f\u3001\u5c11\u306a\u304f\u3068\u30822\u3064\u306e\u9069\u5207\u306b\u6295\u4e0e\u3055\u308c\u305f\u5f93\u6765\u306e\u6297\u3046\u3064\u85ac\u6cbb\u7642\u306b\u53cd\u5fdc\u3057\u306a\u3044\u3053\u3068\u3068\u5b9a\u7fa9\u3055\u308c\u307e\u3059\u3002\u3053\u306e\u6587\u66f8\u306f\u3001\u30e2\u30ce\u30a2\u30df\u30f3\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u306e\u76f8\u4e92\u4f5c\u7528\u3068\u795e\u7d4c\u708e\u75c7\u306e\u5f79\u5272\u3092\u5f37\u8abf\u3057\u306a\u304c\u3089\u3001TRD\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u8b70\u8ad6\u3057\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u30c9\u30fc\u30d1\u30df\u30f3\u306e\u5f79\u5272<\/strong>: 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\u3046\u3064\u75c5\u306e\u75c7\u72b6\u306f\u3001\u6cbb\u7642\u53cd\u5fdc\u6027\uff08\u30bb\u30ed\u30c8\u30cb\u30f3\u4f5c\u52d5\u6027\u7642\u6cd5\u3067\u7de9\u548c\u3055\u308c\u308b\u60c5\u52d5\u30fb\u8a8d\u77e5\u95a2\u9023\uff09\u3068\u6cbb\u7642\u62b5\u6297\u6027\uff08\u30c9\u30fc\u30d1\u30df\u30f3\u304a\u3088\u3073\u30ce\u30eb\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u6b20\u4e4f\u306b\u95a2\u9023\u3059\u308b\u8eab\u4f53\u95a2\u9023\uff09\u306b\u5206\u985e\u3055\u308c\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u4eca\u5f8c\u306e\u65b9\u5411\u6027<\/strong>: TRD\u306e\u52b9\u679c\u7684\u306a\u7ba1\u7406\u306b\u306f\u3001\u591a\u6a19\u7684\u85ac\u7269\u7642\u6cd5\u3068\u5fc3\u7406\u7642\u6cd5\u3084\u305d\u306e\u4ed6\u306e\u975e\u85ac\u7406\u5b66\u7684\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u306a\u3069\u3001\u30b5\u30d6\u30bf\u30a4\u30d7\u7279\u7570\u7684\u304b\u3064\/\u307e\u305f\u306f\u500b\u5225\u5316\u3055\u308c\u305f\u6cbb\u7642\u30e2\u30c0\u30ea\u30c6\u30a3\u3092\u7528\u3044\u3066\u3001\u8907\u6570\u306e\u76f8\u4e92\u4f5c\u7528\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u304c\u5fc5\u8981\u3067\u3059\u3002\u4eca\u5f8c\u306e\u7814\u7a76\u306f\u3001\u73fe\u5728\u306e\u9650\u754c\u3092\u514b\u670d\u3059\u308b\u305f\u3081\u306b\u3001\u76f8\u4e92\u4f5c\u7528\u30e1\u30ab\u30cb\u30ba\u30e0\u304a\u3088\u3073\u591a\u89d2\u7684\u307e\u305f\u306f\u53ce\u675f\u7684\u30e1\u30ab\u30cb\u30ba\u30e0\u7279\u7570\u7684\u306a\u6297\u3046\u3064\u7642\u6cd5\u306b\u7126\u70b9\u3092\u5f53\u3066\u308b\u3079\u304d\u3067\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u5143\u306e\u8a18\u4e8b\u306e\u30ea\u30f3\u30af\uff1a\u3000<a href=\"https:\/\/link.springer.com\/article\/10.1186\/s43556-024-00205-y\">https:\/\/link.springer.com\/article\/10.1186\/s43556-024-00205-y<\/a><\/p>\n\n\n\n<p>\u5143\u306e\u8a18\u4e8b\u306e\u30e9\u30a4\u30bb\u30f3\u30b9\uff1a\u3000CC-BY  <a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">https:\/\/creativecommons.org\/licenses\/by\/4.0\/<\/a><\/p>\n\n\n\n<p>\u66f8\u8a8c\u4e8b\u9805\uff1aKajumba, M.M., Kakooza-Mwesige, A., Nakasujja, N. et al. Treatment-resistant depression: molecular mechanisms and management. Mol Biomed 5, 43 (2024). https:\/\/doi.org\/10.1186\/s43556-024-00205-y<\/p>\n\n\n\n<p>\u6539\u5909\uff1a\u672c\u30b3\u30f3\u30c6\u30f3\u30c4\u306f\u53c2\u7167\u3057\u305f\u8ad6\u6587\u306e\u5185\u5bb9\u306b\u57fa\u3065\u3044\u3066\u3001\u751f\u6210AI\u306b\u3088\u308a\u305d\u306e\u5185\u5bb9\u3092\u307e\u3068\u3081\u306a\u304a\u3057\u305f\u3082\u306e\u3067\u3059\u3002AI\u306e\u9650\u754c\u3068\u3057\u3066\u30cf\u30eb\u30b7\u30cd\u30fc\u30b7\u30e7\u30f3\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u6f22\u5b57\u306e\u8aad\u307f\u9593\u9055\u3044\u304c\u5b58\u5728\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-audio\"><audio controls src=\"https:\/\/plaza.umin.ac.jp\/~OIO\/s2d\/wp-content\/uploads\/sites\/3\/2025\/07\/80402648025e5371e71c7b0e73abc80d.mp3\"><\/audio><\/figure>\n<div class=\"powerpress_player\" id=\"powerpress_player_4996\"><audio class=\"wp-audio-shortcode\" id=\"audio-1887-1\" preload=\"none\" style=\"width: 100%;\" controls=\"controls\"><source type=\"audio\/mpeg\" src=\"https:\/\/media.blubrry.com\/3954323\/plaza.umin.ac.jp\/~OIO\/s2d\/wp-content\/uploads\/sites\/3\/2025\/07\/80402648025e5371e71c7b0e73abc80d.mp3?_=1\" \/><a href=\"https:\/\/media.blubrry.com\/3954323\/plaza.umin.ac.jp\/~OIO\/s2d\/wp-content\/uploads\/sites\/3\/2025\/07\/80402648025e5371e71c7b0e73abc80d.mp3\">https:\/\/media.blubrry.com\/3954323\/plaza.umin.ac.jp\/~OIO\/s2d\/wp-content\/uploads\/sites\/3\/2025\/07\/80402648025e5371e71c7b0e73abc80d.mp3<\/a><\/audio><\/div><p class=\"powerpress_links powerpress_links_mp3\" style=\"margin-bottom: 1px !important;\">Podcast: <a href=\"https:\/\/media.blubrry.com\/3954323\/plaza.umin.ac.jp\/~OIO\/s2d\/wp-content\/uploads\/sites\/3\/2025\/07\/80402648025e5371e71c7b0e73abc80d.mp3\" class=\"powerpress_link_pinw\" target=\"_blank\" title=\"Play in new window\" onclick=\"return powerpress_pinw('https:\/\/plaza.umin.ac.jp\/~OIO\/s2d\/?powerpress_pinw=1887-podcast');\" rel=\"nofollow\">Play in new window<\/a> | <a href=\"https:\/\/media.blubrry.com\/3954323\/plaza.umin.ac.jp\/~OIO\/s2d\/wp-content\/uploads\/sites\/3\/2025\/07\/80402648025e5371e71c7b0e73abc80d.mp3\" class=\"powerpress_link_d\" title=\"Download\" rel=\"nofollow\" download=\"80402648025e5371e71c7b0e73abc80d.mp3\">Download<\/a><\/p><!--powerpress_player-->","protected":false},"excerpt":{"rendered":"<p>\u8a18\u4e8b\u306e\u6982\u8981\u3067\u3059 \u300cTreatment-resistant depression: molecular mechanisms and management(\u6cbb\u7642\u62b5\u6297\u6027\u3046\u3064\u75c5\uff1a\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u7ba1\u7406)\u300d\u3068\u984c\u3055\u308c\u305f\u3053\u306e\u6587\u66f8\u306f\u3001\u3046\u3064\u75c5\u3001\u7279\u306b\u6cbb\u7642\u62b5\u6297\u6027\u3046\u3064\u75c5\uff08TRD\uff09\u306b\u95a2\u3059\u308b\u7406\u89e3\u3092\u30ec\u30d3\u30e5\u30fc\u3057\u3066\u3044\u307e\u3059\u3002\u3046\u3064\u75c5\u304c\u975e\u5e38\u306b\u4e0d\u5747\u4e00\u3067\u3042\u308a\u3001\u500b\u4eba\u9593\u3067\u57fa\u790e\u3068\u306a\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u591a\u69d8\u3067\u3042\u308b\u3053\u3068\u3001\u307e\u305f\u73fe\u5728\u306e\u7b2c\u4e00\u9078\u629e\u85ac\u3067\u3042\u308b\u6297\u3046\u3064\u85ac\u304c\u60a3\u8005\u306e\u307b\u307c66%\u306b\u52b9\u679c\u304c\u306a\u3044\u3053\u3068\u3092\u5f37\u8abf\u3057\u3066\u3044\u307e\u3059\u3002 \u4e3b\u306a\u767a\u898b\u3068\u8b70\u8ad6\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3059\u3002 \u5143\u306e\u8a18\u4e8b\u306e\u30ea\u30f3\u30af\uff1a\u3000https:\/\/link.springer.com\/article\/10.1186\/s43556-024-00205-y \u5143\u306e\u8a18\u4e8b\u306e\u30e9\u30a4\u30bb\u30f3\u30b9\uff1a\u3000CC-BY https:\/\/creativecommons.org\/licenses\/by\/4.0\/ \u66f8\u8a8c\u4e8b\u9805\uff1aKajumba, M.M., Kakooza-Mwesige, A., Nakasujja, N. et al. Treatment-resistant depression: molecular mechanisms and management. Mol Biomed 5, 43 (2024). https:\/\/doi.org\/10.1186\/s43556-024-00205-y \u6539\u5909\uff1a\u672c\u30b3\u30f3\u30c6\u30f3\u30c4\u306f\u53c2\u7167\u3057\u305f\u8ad6\u6587\u306e\u5185\u5bb9\u306b\u57fa\u3065\u3044\u3066\u3001\u751f\u6210AI\u306b\u3088\u308a\u305d\u306e\u5185\u5bb9\u3092\u307e\u3068\u3081\u306a\u304a\u3057\u305f\u3082\u306e\u3067\u3059\u3002AI\u306e\u9650\u754c\u3068\u3057\u3066\u30cf\u30eb\u30b7\u30cd\u30fc\u30b7\u30e7\u30f3\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u6f22\u5b57\u306e\u8aad\u307f\u9593\u9055\u3044\u304c\u5b58\u5728\u3057\u307e\u3059\u3002 https:\/\/media.blubrry.com\/3954323\/plaza.umin.ac.jp\/~OIO\/s2d\/wp-content\/uploads\/sites\/3\/2025\/07\/80402648025e5371e71c7b0e73abc80d.mp3 Podcast: Play in new window | Download<\/p>\n","protected":false},"author":1,"featured_media":1915,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[7,8],"tags":[],"class_list":["post-1887","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ab","category-podcast"],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/plaza.umin.ac.jp\/~OIO\/s2d\/wp-content\/uploads\/sites\/3\/2025\/07\/Gemini_Generated_Image_bl7tetbl7tetbl7t.png?fit=2048%2C2048&ssl=1","jetpack-related-posts":[],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/s2d\/wp-json\/wp\/v2\/posts\/1887","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/s2d\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/s2d\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/s2d\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/s2d\/wp-json\/wp\/v2\/comments?post=1887"}],"version-history":[{"count":5,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/s2d\/wp-json\/wp\/v2\/posts\/1887\/revisions"}],"predecessor-version":[{"id":1914,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/s2d\/wp-json\/wp\/v2\/posts\/1887\/revisions\/1914"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/s2d\/wp-json\/wp\/v2\/media\/1915"}],"wp:attachment":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/s2d\/wp-json\/wp\/v2\/media?parent=1887"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/s2d\/wp-json\/wp\/v2\/categories?post=1887"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/s2d\/wp-json\/wp\/v2\/tags?post=1887"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}