{"id":945,"date":"2017-12-09T18:01:37","date_gmt":"2017-12-09T09:01:37","guid":{"rendered":"https:\/\/plaza.umin.ac.jp\/~OIO\/?p=945"},"modified":"2017-12-28T21:20:54","modified_gmt":"2017-12-28T12:20:54","slug":"case-crossover-design-2","status":"publish","type":"post","link":"https:\/\/plaza.umin.ac.jp\/~OIO\/?p=945","title":{"rendered":"Case Crossover Design (2)"},"content":{"rendered":"<h2>Case Crossover Design \u2013 (2)<\/h2>\n<h3>Relative Risk\u306e\u8a08\u7b97\u306e\u6d41\u308c<\/h3>\n<p><a href=\"https:\/\/wp.me\/p9b6zl-e7\">\u524d\u56de\u306e\u30b3\u30fc\u30c9<\/a>\u3092\u5c11\u3057\u8a73\u3057\u304f\u898b\u3066\u3086\u304d\u307e\u3059\u3002<\/p>\n<p>\u30b3\u30fc\u30d2\u30fc\u306e\u4e00\u6642\u7684\u306a\u52b9\u679c\u306f\u3001\u98f2\u3093\u3067\u304b\u30891\u6642\u9593\u7d99\u7d9a\u3059\u308b\u3068\u4eee\u5b9a\u3057\u307e\u3059\u3002Vector c \u306b\u306f\u3001AMI\u3067\u6551\u6025\u5916\u6765\u3092\u53d7\u8a3a\u3057\u305f\u60a3\u8005\u3055\u3093\u304b\u3089\u805e\u304d\u53d6\u3063\u305f\u3001\u30b3\u30fc\u30d2\u30fc\u3092\u98f2\u3093\u3067\u304b\u3089AMI\u767a\u75c7\u307e\u3067\u306e\u6642\u9593(hr)\u3092\u4ee3\u5165\u3057\u307e\u3059\u3002<\/p>\n<ul>\n<li>t&lt;-c(9,1\/3,3,22,6,7,12,5,0.5,24)<\/li>\n<\/ul>\n<p>1\u5e74\u9593\u306b\u4f55\u676f\u306e\u30b3\u30fc\u30d2\u30fc\u3092\u98f2\u3080\u304b\u3068\u3044\u3046\u983b\u5ea6(\u676f\/year)\u3092frq\u306b\u4ee3\u5165\u3057\u307e\u3059\u3002\u4eca\u56de\u306e\u3053\u306e\u5024\u306e\u4f7f\u3044\u65b9\u306b\u57fa\u3065\u304d\u3001\u4e00\u822c\u5316\u3057\u3066\u3053\u306e\u30b9\u30af\u30ea\u30d7\u30c8\u3092\u4f7f\u7528\u3059\u308b\u4e0a\u3067\u306f\u30011\u5e74\u3042\u305f\u308a\u306eTransient effect time(hr)\u304cfrq\u3068\u3044\u3046\u898b\u65b9\u306e\u65b9\u304c\u826f\u3044\u3060\u308d\u3046\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n<ul>\n<li>frq&lt;-c(730,365,36,1820,2920,24,730,730,3650,365)<\/li>\n<\/ul>\n<p>T\u306b\u306f\u30011\u5e74\u9593\u306f\u4f55\u6642\u9593\u304b\u3068\u3044\u3046\u5024\u3092\u5165\u308c\u307e\u3059\u3002\u4eca\u56de\u306f\u5168\u75c7\u4f8b1\u5e74\u3092\u89b3\u5bdf\u671f\u9593\u306b\u3057\u305f\u306e\u3067\u5b9a\u6570\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u4e00\u822c\u5316\u3059\u308b\u4e0a\u3067\u306f\u3001\u8a55\u4fa1\u306e\u5bfe\u8c61\u306b\u3057\u305f\u89b3\u5bdf\u671f\u9593\u3068\u7406\u89e3\u3059\u308b\u3068\u826f\u3044\u3060\u308d\u3046\u3068\u601d\u3044\u307e\u3059\u3002\u75c7\u4f8b\u3054\u3068\u306b\u89b3\u5bdf\u671f\u9593\u304c\u9055\u3046\u5834\u5408\u306fT\u3082\u30d9\u30af\u30bf\u30fc\u306b\u3067\u304d\u308b\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n<ul>\n<li>T&lt;-365*24<\/li>\n<\/ul>\n<p>efftime\u306b\u306f\u3001AMI\u306e\u767a\u75c7\u304c\u30b3\u30fc\u30d2\u30fc\u3092\u98f2\u3093\u30671\u6642\u9593\u4ee5\u4e0a\u7d4c\u904e\u3057\u3066\u3044\u305f\u3089false (0), 1\u6642\u9593\u672a\u6e80\u3067\u3042\u308c\u3070true(1)\u3068\u3044\u3046\u30d5\u30e9\u30b0\u3092\u4ee3\u5165\u3057\u307e\u3059\u3002Transient effect time\u30921hr\u306b\u3057\u3066\u3044\u307e\u3059\u306e\u3067\u3001\u5224\u5b9a\u306e\u6761\u4ef6\u306f t&gt;=1\u3092\u4f7f\u7528\u3057\u3066\u3044\u307e\u3059\u304c\u3001Transient effect time\u304c2hr\u306a\u3089\u5224\u5b9a\u6761\u4ef6\u3092t&gt;=2\u306b\u3057\u305f\u3089\u3088\u3044\u3067\u3057\u3087\u3046\u3002\u305d\u306e\u969b\u3082\u30d5\u30e9\u30b0\uff08\u8fd4\u308a\u5024\uff09\u306f 0, 1\u306e\u307e\u307e\u3067\u7d50\u69cb\u3067\u3059\u3002<\/p>\n<ul>\n<li>efftime&lt;-ifelse(t&gt;=1,0,1)<\/li>\n<\/ul>\n<h3>RR\u306e\u8a08\u7b97<\/h3>\n<p>Mantel-Haenszel\u306e\u8a08\u7b97\u5f0f\u304b\u3089RR (relative risk) \u3092\u8a08\u7b97\u3057\u307e\u3059<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-947\" src=\"https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2017\/12\/0CaseCross1.png\" alt=\"\" width=\"559\" height=\"262\" srcset=\"https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2017\/12\/0CaseCross1.png 559w, https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2017\/12\/0CaseCross1-150x70.png 150w, https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2017\/12\/0CaseCross1-300x141.png 300w\" sizes=\"auto, (max-width: 559px) 100vw, 559px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-948\" src=\"https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2017\/12\/0CaseCross2.png\" alt=\"\" width=\"288\" height=\"84\" srcset=\"https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2017\/12\/0CaseCross2.png 288w, https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2017\/12\/0CaseCross2-150x44.png 150w\" sizes=\"auto, (max-width: 288px) 100vw, 288px\" \/><\/p>\n<p>\u3068\u3057\u307e\u3057\u305f\u306e\u3067\u3001\u6b21\u306e\u5f0f\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<ul>\n<li>rr&lt;-sum(efftime*(T-frq))\/sum((1-efftime)*frq)<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>\u5206\u6563\u3092\u6c42\u3081\u308b\u5f0f\u3067\u306f<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-949\" src=\"https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2017\/12\/0CaseCross3.png\" alt=\"\" width=\"489\" height=\"110\" srcset=\"https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2017\/12\/0CaseCross3.png 489w, https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2017\/12\/0CaseCross3-150x34.png 150w, https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2017\/12\/0CaseCross3-300x67.png 300w\" sizes=\"auto, (max-width: 489px) 100vw, 489px\" \/><\/p>\n<p>\u3053\u306e\u90e8\u5206\u3092\u30b3\u30fc\u30c9\u5316\u3059\u308b\u3068<\/p>\n<ul>\n<li>var.log&lt;-sum(frq*(T-frq))\/(sum(efftime*(T-frq))*sum((1-efftime)*frq))<\/li>\n<\/ul>\n<p>\u6a19\u6e96\u8aa4\u5dee\u306f\u5206\u6563\u306e\u5e73\u65b9\u6839\u3067\u4ee5\u4e0b\u306e\u3088\u3046\u306b\u306a\u308a\u307e\u3059<\/p>\n<ul>\n<li>se.log&lt;-sqrt(var.log)<\/li>\n<li>lo.log&lt;-log(rr)-1.96*se.log<\/li>\n<li>hi.log&lt;-log(rr)+1.96*se.log<\/li>\n<li>lo&lt;-exp(lo.log)<\/li>\n<li>hi&lt;-exp(hi.log)<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>OR\u306e\u8a08\u7b97<\/h3>\n<p>\u30aa\u30c3\u30ba\u6bd4\u306f\u6b21\u306e\u5f0f\u3067\u8868\u73fe\u3055\u308c\u307e\u3059\u306e\u3067<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-950\" src=\"https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2017\/12\/0CaseCross4.png\" alt=\"\" width=\"293\" height=\"119\" srcset=\"https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2017\/12\/0CaseCross4.png 293w, https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2017\/12\/0CaseCross4-150x61.png 150w\" sizes=\"auto, (max-width: 293px) 100vw, 293px\" \/><\/p>\n<p>\u3053\u308c\u3092\u30b3\u30fc\u30c9\u5316\u3059\u308b\u3068<\/p>\n<ul>\n<li>or&lt;-sum(efftime*(T-frq-(1-efftime)))\/sum((1-efftime)*(frq-efftime))<\/li>\n<\/ul>\n<p>\u5206\u6563\u306f\u6b21\u306e\u3088\u3046\u306b\u8868\u73fe\u3055\u308c\u307e\u3059\u306e\u3067\uff08\u5143\u8ad6\u6587\u306e\u3053\u306e\u5f0f\u306e\u300c\uff1d\u300d\u306e\u5de6\u5074\u3001var[ln(RRchm)] \u306f\u3001\u304a\u305d\u3089\u304fvar[ln(ORchm)]\u306e\u8aa4\u690d\u3060\u308d\u3046\u3068\u601d\u3063\u3066\u3044\u307e\u3059\uff09<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-951\" src=\"https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2017\/12\/0CaseCross5.png\" alt=\"\" width=\"617\" height=\"237\" srcset=\"https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2017\/12\/0CaseCross5.png 617w, https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2017\/12\/0CaseCross5-150x58.png 150w, https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2017\/12\/0CaseCross5-300x115.png 300w\" sizes=\"auto, (max-width: 617px) 100vw, 617px\" \/><\/p>\n<p>\u3053\u308c\u3092\u30b3\u30fc\u30c9\u5316\u3059\u308b\u3068\u6b21\u306e\u3088\u3046\u306b\u306a\u308a\u307e\u3059<\/p>\n<ul>\n<li>var.log.or&lt;-(sum(efftime*(T-frq-1+efftime)*(efftime+ T-frq-1+efftime))\/(2*(sum(efftime*(T-frq-1+efftime)))^2))+(sum(efftime*(T-frq-1+efftime)*(1-efftime+frq-efftime)+(1-efftime)*(frq-efftime)*(efftime+(T-frq-1+efftime)))\/(2*sum(efftime*(T-frq-1+efftime))*sum((1-efftime)*(frq-efftime))))+(sum((1-efftime)*(frq-efftime)*(1-efftime+frq-efftime))\/(2*(sum((1-efftime)*(frq-efftime)))^2))<\/li>\n<\/ul>\n<p>\u6a19\u6e96\u8aa4\u5dee\u306f\u5206\u6563\u306e\u5e73\u65b9\u6839\u3067\u4ee5\u4e0b\u306e\u3088\u3046\u306b\u306a\u308a\u307e\u3059<\/p>\n<ul>\n<li>se.log.or&lt;-sqrt(var.log.or)<\/li>\n<li>lo.log.or&lt;-log(or)-1.96*se.log.or<\/li>\n<li>hi.log.or&lt;-log(or)+1.96*se.log.or<\/li>\n<li>lo.or&lt;-exp(lo.log.or)<\/li>\n<li>hi.or&lt;-exp(hi.log.or)<\/li>\n<\/ul>\n<p>\u3067\u3001\u96c6\u8a08\u306b\u306f\u3053\u308c\u3068\u306f\u5225\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u7d39\u4ecb\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u306e\u3067<a href=\"https:\/\/wp.me\/p9b6zl-hC\">\u6b21\u306e\u8a18\u4e8b<\/a>\u3078\u3064\u3065\u304d\u307e\u3059<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Case Crossover Design \u2013 (2) Relative Risk\u306e\u8a08\u7b97\u306e\u6d41\u308c \u524d\u56de\u306e\u30b3\u30fc\u30c9\u3092\u5c11\u3057\u8a73\u3057\u304f\u898b\u3066\u3086\u304d\u307e\u3059\u3002 \u30b3\u30fc\u30d2\u30fc\u306e\u4e00\u6642\u7684\u306a\u52b9\u679c\u306f\u3001\u98f2\u3093\u3067\u304b\u30891\u6642\u9593\u7d99\u7d9a\u3059\u308b\u3068\u4eee\u5b9a\u3057\u307e\u3059\u3002Vector c \u306b&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":true,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[4],"tags":[],"class_list":["post-945","post","type-post","status-publish","format-standard","hentry","category-science"],"jetpack_featured_media_url":"","jetpack_shortlink":"https:\/\/wp.me\/p9b6zl-ff","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/posts\/945","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=945"}],"version-history":[{"count":0,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/posts\/945\/revisions"}],"wp:attachment":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=945"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=945"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=945"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}