{"id":3976,"date":"2026-03-31T13:57:34","date_gmt":"2026-03-31T04:57:34","guid":{"rendered":"https:\/\/plaza.umin.ac.jp\/~OIO\/?p=3976"},"modified":"2026-03-31T13:57:38","modified_gmt":"2026-03-31T04:57:38","slug":"69%e6%ad%b3%e7%94%b7%e6%80%a7%e3%80%80%e6%8a%97gad%e6%8a%97%e4%bd%93%e9%99%bd%e6%80%a7%e7%b3%96%e5%b0%bf%e7%97%85","status":"publish","type":"post","link":"https:\/\/plaza.umin.ac.jp\/~OIO\/?p=3976","title":{"rendered":"69\u6b73\u7537\u6027\u3000\u6297GAD\u6297\u4f53\u967d\u6027\u7cd6\u5c3f\u75c5"},"content":{"rendered":"\n<p>1. \u75c7\u4f8b\u80cc\u666f\uff08\u65e2\u5f80\u6b74\u30fb\u7d4c\u904e\uff09<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u57fa\u672c\u5c5e\u6027:<\/strong> 69\u6b73\u306e\u7537\u6027\u3067\u3059\u3002<\/li>\n\n\n\n<li><strong>\u7cd6\u5c3f\u75c5\u306e\u7d4c\u904e:<\/strong> <strong>14\u5e74\u524d\u306b\u7cd6\u5c3f\u75c5\u3068\u8a3a\u65ad<\/strong>\u3055\u308c\u307e\u3057\u305f\u3002<\/li>\n\n\n\n<li><strong>\u7d39\u4ecb\u6642\u306e\u72b6\u6cc1:<\/strong> 11\u5e74\u524d\u306e\u8840\u6db2\u691c\u67fb\u3067\u306f\u3001<strong>\u6297GAD\u6297\u4f53\u967d\u6027<\/strong>\uff084\u5e74\u524d\u306e\u518d\u691c\u3067\u308243.9 U\/mL\u3068\u967d\u6027\uff09\u3001\u7a7a\u8179\u6642\u8840\u6e05C\u30da\u30d7\u30c1\u30c9 1.3 ng\/mL\u3001HbA1c 6.0%\u3067\u3057\u305f\u3002<\/li>\n\n\n\n<li><strong>\u6cbb\u7642\u6b74:<\/strong> \u3053\u308c\u307e\u3067\u7d4c\u53e3\u8840\u7cd6\u964d\u4e0b\u85ac\u3084\u30a4\u30f3\u30b9\u30ea\u30f3\u306f\u4f7f\u7528\u305b\u305a\u3001HbA1c 6%\u53f0\u524d\u534a\u3067\u7d4c\u904e\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/li>\n\n\n\n<li><strong>\u4f75\u7528\u85ac:<\/strong> \u7cd6\u5c3f\u75c5\u4ee5\u5916\u306b\u3001\u9ad8\u8102\u8840\u75c7\u3084\u9ad8\u8840\u5727\u306a\u3069\u306e\u6cbb\u7642\u306e\u305f\u3081\u3001\u30d4\u30bf\u30d0\u30b9\u30bf\u30c1\u30f3\u3001\u30c6\u30eb\u30df\u30b5\u30eb\u30bf\u30f3\u3001\u30d5\u30a7\u30d6\u30ad\u30bd\u30b9\u30bf\u30c3\u30c8\u30922\u5e74\u9593\u7d99\u7d9a\u3057\u3066\u670d\u7528\u3057\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p>2. \u73fe\u75c7\uff08\u8eab\u4f53\u6240\u898b\u30fb\u75c7\u72b6\uff09<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u4f53\u683c:<\/strong> \u8eab\u9577 173 cm\u3001\u4f53\u91cd 67 kg\u3001<strong>BMI 22.3 kg\/m\u00b2<\/strong>\u3067\u3042\u308a\u3001\u3053\u3053\u6570\u5e74\u306e\u4f53\u91cd\u5909\u52d5\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/li>\n\n\n\n<li><strong>\u5408\u4f75\u75c7:<\/strong> <strong>\u7cd6\u5c3f\u75c5\u7db2\u819c\u75c7\u306f\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093<\/strong>\u3002<\/li>\n<\/ul>\n\n\n\n<p>3. \u691c\u67fb\u6240\u898b<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u8840\u7cd6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb:<\/strong> <strong>HbA1c 7.8%<\/strong>\uff08\u76f4\u8fd13\u304b\u6708\u9593\u306f7.0%\u3092\u8d85\u3048\u3066\u304a\u308a\u3001\u305d\u308c\u4ee5\u524d\u306f7.0%\u672a\u6e80\u3067\u3057\u305f\uff09\u3002<\/li>\n\n\n\n<li><strong>\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u80fd:<\/strong> <strong>\u7a7a\u8179\u6642\u8840\u6e05C\u30da\u30d7\u30c1\u30c9\u306f 1.33 ng\/mL<\/strong>\u3067\u3042\u308a\u3001\u904e\u53bb2\u5e74\u9593\u306e\u63a8\u79fb\uff081.26 \u2192 1.18 ng\/mL\uff09\u3092\u898b\u3066\u3082\u3001<strong>\u5185\u56e0\u6027\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u80fd\u306f\u4fdd\u6301<\/strong>\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u814e\u6a5f\u80fd:<\/strong> \u5c3f\u4e2d\u30a2\u30eb\u30d6\u30df\u30f3\/\u30af\u30ec\u30a2\u30c1\u30cb\u30f3\u6bd4\u306f 12.6 mg\/g\u30fbCr\u3067\u3042\u308a\u3001\u57fa\u6e96\u5024\uff0830\u672a\u6e80\uff09\u5185\u3067\u3059\u3002<\/li>\n\n\n\n<li><strong>\u305d\u306e\u4ed6:<\/strong> \u6628\u5e74\u5b9f\u65bd\u3057\u305f\u4e0a\u4e0b\u90e8\u5185\u8996\u93e1\u691c\u67fb\u304a\u3088\u3073\u8179\u90e8\u8d85\u97f3\u6ce2\u691c\u67fb\u3067\u306f\u3001\u7570\u5e38\u306f\u8a8d\u3081\u3089\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/li>\n<\/ul>\n\n\n\n<p>4. \u81e8\u5e8a\u8a3a\u65ad<\/p>\n\n\n\n<p>\u3053\u306e\u75c7\u4f8b\u306f\u3001\u6297GAD\u6297\u4f53\u304c\u967d\u6027\u3067\u3042\u308b\u3082\u306e\u306e\u3001\u6700\u7d42\u89b3\u5bdf\u6642\u70b9\u3067\u306e\u7a7a\u8179\u6642\u8840\u6e05C\u30da\u30d7\u30c1\u30c9\u304c0.6 ng\/mL\u4ee5\u4e0a\u3067\u3042\u308a\u3001\u5185\u56e0\u6027\u30a4\u30f3\u30b9\u30ea\u30f3\u6b20\u4e4f\u72b6\u614b\u306b\u306f\u81f3\u3063\u3066\u3044\u306a\u3044\u3053\u3068\u304b\u3089\u30012023\u5e74\u306e\u65b0\u8a3a\u65ad\u57fa\u6e96\u306b\u304a\u3051\u308b**\u300c\u7de9\u5f90\u9032\u884c1\u578b\u7cd6\u5c3f\u75c5\uff08SPIDDM\uff1aprobable\uff09\u300d<strong>\u3001\u3059\u306a\u308f\u3061<\/strong>\u7de9\u5f90\u9032\u884c1\u578b\u7cd6\u5c3f\u75c5\u7591\u3044\u4f8b**\u3068\u8a3a\u65ad\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-audio\"><audio controls src=\"https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2026\/03\/80375fbeea5ab39636d84513298585ca.mp3\"><\/audio><\/figure>\n\n\n\n<p><strong>\u7de9\u5f90\u9032\u884c1\u578b\u7cd6\u5c3f\u75c5\uff08SPIDDM\uff09\u7591\u3044\u4f8b\uff08probable\uff09\u306b\u304a\u3051\u308b\u8a3a\u7642\u7ba1\u7406\u30d7\u30ed\u30c8\u30b3\u30eb\uff1a2023\u5e74\u6539\u8a02\u57fa\u6e96\u306b\u57fa\u3065\u304f\u5b9f\u8df5\u6307\u91dd<\/strong><\/p>\n\n\n\n<p><strong>1. <\/strong><strong>\u7dd2\u8a00\uff1a2023\u5e74\u6539\u8a02\u8a3a\u65ad\u57fa\u6e96\u306e\u6226\u7565\u7684\u610f\u7fa9<\/strong><\/p>\n\n\n\n<p>2023\u5e74\u3001\u7de9\u5f90\u9032\u884c1\u578b\u7cd6\u5c3f\u75c5\uff08SPIDDM\uff09\u306e\u8a3a\u65ad\u57fa\u6e96\u306f\u30012012\u5e74\u306e\u7b56\u5b9a\u304b\u308910\u5e74\u4ee5\u4e0a\u306e\u6b73\u6708\u3092\u7d4c\u3066\u5927\u304d\u306a\u8ee2\u63db\u671f\u3092\u8fce\u3048\u307e\u3057\u305f\u3002\u4eca\u56de\u306e\u6539\u8a02\u306b\u304a\u3051\u308b\u6700\u5927\u306e\u6226\u7565\u7684\u610f\u7fa9\u306f\u3001\u75c5\u614b\u3092**\u300cdefinite\uff08\u78ba\u5b9a\uff09\u300d<strong>\u3068<\/strong>\u300cprobable\uff08\u7591\u3044\uff09\u300d**\u306e2\u3064\u306e\u30ab\u30c6\u30b4\u30ea\u30fc\u306b\u660e\u78ba\u306b\u5206\u96e2\u3057\u305f\u70b9\u306b\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u5f93\u6765\u306e2012\u5e74\u57fa\u6e96\u3067\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u4f9d\u5b58\u72b6\u614b\u3078\u306e\u9032\u884c\u30ea\u30b9\u30af\u304c\u660e\u3089\u304b\u306aGAD\u6297\u4f53\u3068ICA\uff08\u81b5\u5cf6\u7d30\u80de\u6297\u4f53\uff09\u306e\u307f\u3092\u5bfe\u8c61\u3068\u3057\u3066\u304a\u308a\u3001IA-2\u6297\u4f53\u5358\u72ec\u967d\u6027\u4f8b\u306a\u3069\u306e\u6271\u3044\u304c\u4e0d\u660e\u78ba\u3067\u3057\u305f\u3002\u307e\u305f\u3001\u81ea\u5df1\u6297\u4f53\u967d\u6027\u4f8b\u3067\u3042\u3063\u3066\u3082\u5168\u4f8b\u304c\u5fc5\u305a\u3057\u3082\u30a4\u30f3\u30b9\u30ea\u30f3\u4f9d\u5b58\u72b6\u614b\u3078\u9032\u884c\u3059\u308b\u308f\u3051\u3067\u306f\u306a\u3044\u3068\u3044\u3046\u77e5\u898b\u304c\u84c4\u7a4d\u3055\u308c\u3001\u300c\u9032\u884c\u30ea\u30b9\u30af\u306e\u591a\u69d8\u6027\u300d\u3078\u306e\u5bfe\u5fdc\u304c\u6025\u52d9\u3068\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u300cprobable\u300d\u3068\u3044\u3046\u30ab\u30c6\u30b4\u30ea\u30fc\u306e\u65b0\u8a2d\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u975e\u4f9d\u5b58\u72b6\u614b\u306b\u3042\u308b\u75c7\u4f8b\u306b\u5bfe\u3057\u3001\u65e9\u671f\u306e\u4e00\u5f8b\u7684\u306a\u30a4\u30f3\u30b9\u30ea\u30f3\u5c0e\u5165\u3068\u3044\u3046\u56fa\u5b9a\u6982\u5ff5\u3092\u8131\u5374\u3057\u3001\u60a3\u8005\u500b\u3005\u306e\u30ea\u30b9\u30af\u306b\u5fdc\u3058\u305f\u300c\u67d4\u8edf\u306a\u6cbb\u7642\u9078\u629e\u300d\u3068\u300c\u53b3\u5bc6\u306a\u7d4c\u904e\u89b3\u5bdf\u300d\u3092\u4e21\u7acb\u3055\u305b\u308b\u305f\u3081\u306b\u4e0d\u53ef\u6b20\u306a\u63aa\u7f6e\u3067\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u6d77\u5916\u306eLADA\u6982\u5ff5\u3068\u306e\u6574\u5408\u6027\u3092\u4fdd\u3061\u3064\u3064\u3001\u65e5\u672c\u306e\u81e8\u5e8a\u5b9f\u614b\u306b\u5373\u3057\u305f\u7ba1\u7406\u304c\u53ef\u80fd\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u6b63\u78ba\u306a\u8a3a\u65ad\u304b\u3089\u7ba1\u7406\u3092\u958b\u59cb\u3059\u308b\u305f\u3081\u306e\u4f53\u7cfb\u7684\u30d5\u30ed\u30fc\u3092\u6b21\u7ae0\u3067\u6574\u7406\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n\n\n\n<p><strong>2. <\/strong><strong>\u8a3a\u65ad\u57fa\u6e96\u306e\u4f53\u7cfb\u7684\u6574\u7406\u3068\u300cprobable\u300d\u306e\u5b9a\u7fa9<\/strong><\/p>\n\n\n\n<p>SPIDDM\u306e\u8a3a\u65ad\u306f\u3001\u81ea\u5df1\u6297\u4f53\u306e\u6709\u7121\u3001\u767a\u75c7\u6642\u306e\u75c5\u614b\u3001\u304a\u3088\u3073\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u80fd\u306e\u63a8\u79fb\u3068\u3044\u30463\u3064\u306e\u8ef8\u3067\u5224\u5b9a\u3055\u308c\u307e\u3059\u3002\u5c02\u9580\u533b\u306f\u4ee5\u4e0b\u306e\u8a3a\u65ad\u30de\u30c8\u30ea\u30af\u30b9\u306b\u57fa\u3065\u304d\u3001\u901f\u3084\u304b\u306b\u75c5\u614b\u3092\u8b58\u5225\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u25a0 SPIDDM\u8a3a\u65ad\u30de\u30c8\u30ea\u30af\u30b9\uff082023\uff09<\/strong><\/p>\n\n\n\n<p>\u8a3a\u65ad\u306b\u306f\u4ee5\u4e0b\u306e3\u3064\u306e\u5fc5\u9808\u9805\u76ee\u3092\u7528\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ol start=\"1\" class=\"wp-block-list\">\n<li><strong>\u5fc5\u9808\u9805\u76ee1\uff08\u81ea\u5df1\u6297\u4f53\uff09\uff1a<\/strong> \u7d4c\u904e\u306e\u3069\u3053\u304b\u3067\u81b5\u5cf6\u95a2\u9023\u81ea\u5df1\u6297\u4f53\uff08GAD\u3001ICA\u3001IA-2\u3001ZnT8\u3001IAA\u203b\uff09\u306e\u3044\u305a\u308c\u304b\u304c\u967d\u6027\u3067\u3042\u308b\uff08\u203bIAA\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u6cbb\u7642\u958b\u59cb\u524d\u306b\u9650\u308b\uff09\u3002<\/li>\n\n\n\n<li><strong>\u5fc5\u9808\u9805\u76ee2\uff08\u975e\u4f9d\u5b58\u72b6\u614b\uff09\uff1a<\/strong> \u539f\u5247\u3068\u3057\u3066\u7cd6\u5c3f\u75c5\u8a3a\u65ad\u6642\u306b\u30b1\u30c8\u30fc\u30b7\u30b9\u304c\u306a\u304f\u3001\u76f4\u3061\u306b\u30a4\u30f3\u30b9\u30ea\u30f3\u7642\u6cd5\u3092\u5fc5\u8981\u3068\u3057\u306a\u3044\u3002<\/li>\n\n\n\n<li><strong>\u5fc5\u9808\u9805\u76ee3\uff08\u30a4\u30f3\u30b9\u30ea\u30f3\u6b20\u4e4f\uff09\uff1a<\/strong> \u7cd6\u5c3f\u75c5\u8a3a\u65ad\u5f8c3\u30f6\u6708\u3092\u904e\u304e\u3066\u30a4\u30f3\u30b9\u30ea\u30f3\u7642\u6cd5\u304c\u5fc5\u8981\u3068\u306a\u308a\u3001\u6700\u7d42\u7684\u306b\u5185\u56e0\u6027\u30a4\u30f3\u30b9\u30ea\u30f3\u6b20\u4e4f\uff08<strong>\u7a7a\u8179\u6642\u8840\u6e05C\u30da\u30d7\u30c1\u30c9 &lt; 0.6 ng\/mL<\/strong>\uff09\u3068\u306a\u308b\u3002\n<ul class=\"wp-block-list\">\n<li><em>\u6ce8\uff1a\u30a4\u30f3\u30b9\u30ea\u30f3\u4f9d\u5b58\u72b6\u614b\u3078\u306e\u79fb\u884c\u671f\u9593\u306f\u3001\u5178\u578b\u4f8b\u3067\u306f6\u30f6\u6708\u4ee5\u4e0a\u3092\u8981\u3059\u308b\u3002<\/em><\/li>\n<\/ul>\n<\/li>\n<\/ol>\n\n\n\n<p><strong>\u3010\u5224\u5b9a\u533a\u5206\u3011<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>definite<\/strong><strong>\uff08\u78ba\u5b9a\uff09\uff1a<\/strong> \u9805\u76ee1\u30012\u30013\u306e\u3059\u3079\u3066\u3092\u6e80\u305f\u3059\u72b6\u614b\u3002<\/li>\n\n\n\n<li><strong>probable<\/strong><strong>\uff08\u7591\u3044\uff09\uff1a<\/strong> <strong>\u9805\u76ee1\u30012\u306e\u307f\u3092\u6e80\u305f\u3057\u3001\u9805\u76ee3\uff08\u30a4\u30f3\u30b9\u30ea\u30f3\u6b20\u4e4f\uff09\u3092\u307e\u3060\u6e80\u305f\u3057\u3066\u3044\u306a\u3044\u72b6\u614b\u3002<\/strong><\/li>\n<\/ul>\n\n\n\n<p><strong>\u25a0 \u81e8\u5e8a\u7684\u6982\u5ff5\u306e\u91cd\u306a\u308a<\/strong><\/p>\n\n\n\n<p>\u300cprobable\u300d\u306f\u3001\u6d77\u5916\u306e**LADA\uff08latent autoimmune diabetes in adults\uff09<strong>\u306e\u4e3b\u8981\u6982\u5ff5\u3092\u5305\u542b\u3059\u308b\u3082\u306e\u3067\u3059\u3002\u5178\u578b\u4f8b\u306f35\u6b73\u4ee5\u964d\u306e\u767a\u75c7\u3067\u3059\u304c\u3001\u82e5\u5e74\u8005\u3067\u540c\u69d8\u306e\u7d4c\u904e\u3092\u305f\u3069\u308b\u75c7\u4f8b\u306f<\/strong>LADY\uff08latent autoimmune diabetes in youth\uff09**\u3068\u547c\u3070\u308c\u307e\u3059\u3002\u4eca\u56de\u306e\u6539\u8a02\u306b\u3088\u308a\u3001\u3053\u308c\u3089\u5e83\u7fa9\u306e\u81ea\u5df1\u514d\u75ab\u6027\u7cd6\u5c3f\u75c5\u3092\u300cSPIDDM\u7591\u3044\u300d\u3068\u3057\u3066\u56fd\u5185\u57fa\u6e96\u3067\u7ba1\u7406\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u610f\u7fa9\u306f\u6975\u3081\u3066\u5927\u304d\u3044\u3068\u8a00\u3048\u307e\u3059\u3002\u8a3a\u65ad\u78ba\u5b9a\u5f8c\u306e\u6b21\u306a\u308b\u30b9\u30c6\u30c3\u30d7\u306f\u3001\u500b\u3005\u306e\u75c7\u4f8b\u306e\u9032\u884c\u30ea\u30b9\u30af\u8a55\u4fa1\u3067\u3059\u3002<\/p>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n\n\n\n<p><strong>3. <\/strong><strong>\u30a4\u30f3\u30b9\u30ea\u30f3\u4f9d\u5b58\u72b6\u614b\u3078\u306e\u9032\u884c\u30ea\u30b9\u30af\u8a55\u4fa1<\/strong><\/p>\n\n\n\n<p>SPIDDM\uff08probable\uff09\u75c7\u4f8b\u306b\u304a\u3044\u3066\u3001\u6700\u3082\u91cd\u8981\u306a\u81e8\u5e8a\u5224\u65ad\u306f\u300c\u3044\u3064\u30a4\u30f3\u30b9\u30ea\u30f3\u6b20\u4e4f\u306b\u81f3\u308b\u304b\u300d\u306e\u4e88\u6e2c\u3067\u3059\u3002\u4ee5\u4e0b\u306e\u6307\u6a19\u304c\u8a8d\u3081\u3089\u308c\u308b\u5834\u5408\u306f\u3001\u901f\u3084\u304b\u306a\u9032\u884c\u304c\u61f8\u5ff5\u3055\u308c\u308b\u300c\u30cf\u30a4\u30ea\u30b9\u30af\u7fa4\u300d\u3068\u3057\u3066\u8b66\u6212\u3092\u5f37\u3081\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u25a0 \u9032\u884c\u3092\u4e88\u6e2c\u3059\u308b\u4e3b\u8981\u56e0\u5b50<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u81ea\u5df1\u6297\u4f53\u306e\u529b\u4fa1\u3068\u7a2e\u985e\uff1a<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u8907\u6570\u6297\u4f53\u967d\u6027\uff1a<\/strong> GAD\u6297\u4f53\u306b\u52a0\u3048\u3001IA-2\u6297\u4f53\u3084ZnT8\u6297\u4f53\u304c\u967d\u6027\u3067\u3042\u308b\u5834\u5408\u306f\u3001\u9032\u884c\u30ea\u30b9\u30af\u304c\u6709\u610f\u306b\u9ad8\u3044\uff08Kawasaki\u3089\u306e\u5831\u544a\uff09\u3002<\/li>\n\n\n\n<li><strong>GAD<\/strong><strong>\u6297\u4f53\u4fa1\uff1a<\/strong> \u5f93\u6765\u306eRIA\u6cd5\u3067\u306f\u9ad8\u529b\u4fa1\uff08\u226710 U\/mL\uff09\u304c\u30ea\u30b9\u30af\u56e0\u5b50\u3067\u3057\u305f\u3002\u73fe\u884c\u306eELISA\u6cd5\u306b\u3064\u3044\u3066\u306f\u7d50\u8ad6\u3092\u5f85\u3064\u6bb5\u968e\u3067\u3059\u304c\u3001\u9ad8\u5024\u7dad\u6301\u4f8b\u306b\u306f\u6ce8\u610f\u3092\u8981\u3057\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u3010\u30a8\u30ad\u30b9\u30d1\u30fc\u30c8\u30fb\u30d1\u30fc\u30eb\uff1a\u4fdd\u967a\u8a3a\u7642\u4e0a\u306e\u5236\u9650\u3011<\/strong> \u73fe\u5728\u306e\u65e5\u672c\u306e\u4fdd\u967a\u5236\u5ea6\u4e0a\u3001<strong>GAD\u6297\u4f53\u967d\u6027\u304c\u78ba\u8a8d\u3055\u308c\u305f\u5834\u5408\u3001IA-2\u6297\u4f53\u3084ZnT8\u6297\u4f53\u306e\u6e2c\u5b9a\u306f\u4fdd\u967a\u9069\u7528\u5916<\/strong>\u3068\u306a\u308b\u70b9\u306b\u6ce8\u610f\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u30ea\u30b9\u30af\u8a55\u4fa1\u306e\u305f\u3081\u306e\u8ffd\u52a0\u6e2c\u5b9a\u306b\u306f\u3001\u3053\u306e\u5236\u5ea6\u7684\u5236\u7d04\u3092\u5ff5\u982d\u306b\u7f6e\u304f\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u4f75\u5b58\u75be\u60a3\u3068\u591a\u767a\u6027\u81ea\u5df1\u514d\u75ab\uff1a<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u6297TPO\u6297\u4f53\u967d\u6027\uff08Ehime Study\uff09\uff1a<\/strong> \u7532\u72b6\u817a\u81ea\u5df1\u6297\u4f53\u3067\u3042\u308b\u6297TPO\u6297\u4f53\u967d\u6027\u306f\u3001\u81b5\u03b2\u7d30\u80de\u6a5f\u80fd\u4e0d\u5168\uff08beta cell failure\uff09\u3078\u306e\u9032\u884c\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u672c\u75c5\u614b\u304c\u300c\u591a\u767a\u6027\u81ea\u5df1\u514d\u75ab\uff08polyautoimmunity\uff09\u300d\u306e\u4e00\u74b0\u3068\u3057\u3066\u9032\u884c\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3059\u308b\u91cd\u8981\u306a\u6240\u898b\u3067\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u60a3\u8005\u80cc\u666f\uff1a<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u82e5\u5e74\u767a\u75c7\uff0845\u6b73\u4ee5\u4e0b\uff09\u3001\u4f4eBMI\u3001\u8a3a\u65ad\u6642\u306e\u4f4eC\u30da\u30d7\u30c1\u30c9\u5024\uff1a<\/strong> \u3053\u308c\u3089\u306f\u56fd\u5185\u5916\u306e\u7814\u7a76\uff08UKPDS\u7b49\uff09\u3067\u5171\u901a\u3057\u3066\u6307\u6458\u3055\u308c\u3066\u3044\u308b\u9032\u884c\u52a0\u901f\u56e0\u5b50\u3067\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u30ea\u30b9\u30af\u8a55\u4fa1\u306e\u7d50\u679c\u306f\u3001\u6b21\u7ae0\u3067\u8a73\u8ff0\u3059\u308b\u85ac\u5264\u9078\u629e\u306b\u304a\u3051\u308b\u512a\u5148\u9806\u4f4d\u306e\u6c7a\u5b9a\u8981\u56e0\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n\n\n\n<p><strong>4. <\/strong><strong>\u85ac\u5264\u9078\u629e\u306e\u8ad6\u7406\u7684\u6839\u62e0\u3068\u7981\u5fcc\u6307\u91dd<\/strong><\/p>\n\n\n\n<p>SPIDDM\uff08probable\uff09\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u975e\u4f9d\u5b58\u72b6\u614b\u3067\u3042\u308b\u305f\u3081\u3001\u81b5\u03b2\u7d30\u80de\u4fdd\u8b77\u3092\u6700\u5927\u5316\u3059\u308b\u6226\u7565\u7684\u85ac\u5264\u9078\u629e\u304c\u6c42\u3081\u3089\u308c\u307e\u3059\u3002\u5f53\u59d4\u54e1\u4f1a\u306f\u3001\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u304d\u4ee5\u4e0b\u306e\u30ab\u30c6\u30b4\u30ea\u30fc\u5206\u985e\u3092\u63a8\u5968\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u25a0 \u56de\u907f\u3059\u3079\u304d\u85ac\u5264\uff1aSU\uff08\u30b9\u30eb\u30db\u30cb\u30eb\u5c3f\u7d20\uff09\u85ac<\/strong><\/p>\n\n\n\n<p><strong>\u3010\u8a55\u4fa1\uff1a\u539f\u5247\u56de\u907f\u3011<\/strong> <strong>Tokyo study<\/strong>\u306b\u3088\u308a\u3001SU\u85ac\u306e\u4f7f\u7528\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u7642\u6cd5\u3068\u6bd4\u8f03\u3057\u3066\u5185\u56e0\u6027\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u80fd\u306e\u4f4e\u4e0b\u3092\u6709\u610f\u306b\u4fc3\u9032\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30e1\u30ab\u30cb\u30ba\u30e0\uff08Impact\uff09\uff1a<\/strong> SU\u85ac\u306b\u3088\u308b\u904e\u5ea6\u306a\u03b2\u7d30\u80de\u523a\u6fc0\u304c\u3001\u81b5\u5cf6\u306b\u304a\u3051\u308b<strong>\u6297\u539f\u63d0\u793a\u3092\u4fc3\u9032<\/strong>\u3057\u3001\u514d\u75ab\u62c5\u5f53\u7d30\u80de\u306b\u3088\u308b\u03b2\u7d30\u80de\u7834\u58ca\u3092\u52a0\u901f\u3055\u305b\u308b\u3068\u63a8\u5bdf\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u25a0 \u6cbb\u7642\u9078\u629e\u80a2\u306e\u4f53\u7cfb\u5316\uff08Fig. 1\u306e\u30ab\u30c6\u30b4\u30ea\u30fc\u306b\u57fa\u3065\u304f\uff09<\/strong><\/p>\n\n\n\n<p><strong>\u2460 \u6709\u7528\u6027\u306b\u95a2\u3059\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u3042\u308b\u85ac\u5264\uff08\u63a8\u5968\uff09<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>DPP-4<\/strong><strong>\u963b\u5bb3\u85ac\uff1a<\/strong> \u56fd\u5185\u306e<strong>SPAN-S\u7814\u7a76<\/strong>\u7b49\u306b\u3088\u308a\u3001\u5185\u56e0\u6027\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u80fd\u3092\u4fdd\u6301\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u81b5\u5cf6\u3078\u306e\u30ea\u30f3\u30d1\u7403\u6d78\u6f64\u6291\u5236\u52b9\u679c\u3082\u671f\u5f85\u3055\u308c\u3001\u81e8\u5e8a\u7684\u59a5\u5f53\u6027\u304c\u6975\u3081\u3066\u9ad8\u3044\u9078\u629e\u80a2\u3067\u3059\u3002<\/li>\n\n\n\n<li><strong>\u30d3\u30b0\u30a2\u30ca\u30a4\u30c9\uff08BG\uff09\u85ac\uff1a<\/strong> \u30d1\u30a4\u30ed\u30c3\u30c8\u7814\u7a76\u306b\u304a\u3044\u3066\u3001\u30d4\u30aa\u30b0\u30ea\u30bf\u30be\u30f3\u3088\u308a\u3082\u5206\u6ccc\u80fd\u4fdd\u6301\u306b\u5bc4\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u8178\u5185\u7d30\u83cc\u53e2\u3092\u4ecb\u3057\u305f\u514d\u75ab\u8abf\u6574\u80fd\u306e\u89b3\u70b9\u304b\u3089\u3082\u3001\u4f7f\u7528\u3092\u59a8\u3052\u308b\u6839\u62e0\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/li>\n\n\n\n<li><strong>\u30a4\u30f3\u30b9\u30ea\u30f3\u7642\u6cd5\uff1a<\/strong> \u65e9\u671f\u5c0e\u5165\u306b\u3088\u308a\u81b5\u03b2\u7d30\u80de\u3092\u4f11\u990a\u3055\u305b\u3001\u5206\u6ccc\u80fd\u3092\u4fdd\u6301\u3059\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u3042\u308a\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u73fe\u5728\u306e\u30b3\u30f3\u30bb\u30f3\u30b5\u30b9\u3067\u306f\u300c\u5168\u4f8b\u5fc5\u9808\u300d\u3067\u306f\u306a\u304f\u3001\u4f4e\u30ea\u30b9\u30af\u4f8b\u3067\u306f\u4ed6\u306e\u7d4c\u53e3\u85ac\u3068\u306e\u9078\u629e\u306b\u306a\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u2461 \u6709\u7528\u6027\u306b\u95a2\u3059\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u9650\u5b9a\u7684\u306a\u85ac\u5264<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>GLP-1<\/strong><strong>\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\uff1a<\/strong> HbA1c\u6539\u5584\u52b9\u679c\u306f\u8a8d\u3081\u3089\u308c\u307e\u3059\u304c\u3001\u5206\u6ccc\u80fd\u4fdd\u6301\u306b\u95a2\u3059\u308bSPIDDM\u7279\u7570\u7684\u306a\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u307e\u3060\u4e0d\u5341\u5206\u3067\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u2462 \u63a8\u5968\u3055\u308c\u306a\u3044\u3001\u307e\u305f\u306f\u898b\u89e3\u304c\u306a\u3044\u85ac\u5264<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30d4\u30aa\u30b0\u30ea\u30bf\u30be\u30f3\uff08\u975e\u63a8\u5968\uff09\uff1a<\/strong> \u4ed6\u306e\u85ac\u5264\u306b\u6bd4\u3079\u3001\u5185\u56e0\u6027\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u80fd\u3092\u4fdd\u6301\u3067\u304d\u306a\u3044\u53ef\u80fd\u6027\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>SGLT2<\/strong><strong>\u963b\u5bb3\u85ac\u3001\u03b1-GI\u3001\u30b0\u30ea\u30cb\u30c9\u85ac\u3001\u30a4\u30e1\u30b0\u30ea\u30df\u30f3\uff1a<\/strong> \u73fe\u6642\u70b9\u3067SPIDDM\u306b\u5bfe\u3059\u308b\u898b\u89e3\uff08\u30a8\u30d3\u30c7\u30f3\u30b9\uff09\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u85ac\u5264\u9078\u629e\u5f8c\u306f\u3001\u305d\u306e\u6210\u5426\u3092\u5224\u65ad\u3059\u308b\u305f\u3081\u306e\u53b3\u683c\u306a\u76e3\u8996\u4f53\u5236\u3078\u79fb\u884c\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n\n\n\n<p><strong>5. <\/strong><strong>\u5185\u56e0\u6027\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u80fd\u306e\u76e3\u8996\u3068\u6cbb\u7642\u5f37\u5316\u30d7\u30ed\u30c8\u30b3\u30eb<\/strong><\/p>\n\n\n\n<p>\u6cbb\u7642\u958b\u59cb\u5f8c\u306f\u3001\u75c5\u614b\u306e\u300c\u9032\u884c\u300d\u3092\u65e9\u671f\u306b\u6349\u3048\u308b\u305f\u3081\u3001\u5f53\u59d4\u54e1\u4f1a\u306f\u4ee5\u4e0b\u306e\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u30d5\u30ed\u30fc\u306e\u9075\u5b88\u3092\u63a8\u5968\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u25a0 \u76e3\u8996\u30a2\u30af\u30b7\u30e7\u30f3\u30d7\u30e9\u30f3\uff08Protocol Flow\uff09<\/strong><\/p>\n\n\n\n<ol start=\"1\" class=\"wp-block-list\">\n<li><strong>\u5b9a\u671f\u8a55\u4fa1\uff083\u301c6\u30f6\u6708\u6bce\uff09\uff1a<\/strong> HbA1c\u306b\u3088\u308b\u8840\u7cd6\u7ba1\u7406\u6307\u6a19\u306e\u78ba\u8a8d\u306b\u52a0\u3048\u3001**\u7a7a\u8179\u6642\u8840\u6e05C\u30da\u30d7\u30c1\u30c9\uff08CPR\uff09**\u306e\u5b9a\u671f\u6e2c\u5b9a\u3092\u30eb\u30fc\u30c1\u30f3\u5316\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/li>\n\n\n\n<li><strong>\u9032\u884c\u50be\u5411\u306e\u691c\u77e5\uff1a<\/strong> HbA1c\u306e\u60aa\u5316\u3001\u3042\u308b\u3044\u306fCPR\u5024\u304c\u5f90\u3005\u306b\u4f4e\u4e0b\u3059\u308b\u300c\u4f4e\u4e0b\u30c8\u30ec\u30f3\u30c9\u300d\u3092\u8a8d\u3081\u305f\u5834\u5408\u306f\u3001\u5185\u56e0\u6027\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u80fd\u306e\u6e1b\u8870\u3068\u5224\u65ad\u3057\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u6cbb\u7642\u5f37\u5316\u30fb\u30a4\u30f3\u30b9\u30ea\u30f3\u8ee2\u63db\u306e\u5b9f\u65bd\uff1a<\/strong> \u5206\u6ccc\u80fd\u4f4e\u4e0b\u304c\u7591\u308f\u308c\u305f\u969b\u306f\u3001\u7d4c\u53e3\u85ac\u306b\u56fa\u57f7\u305b\u305a\u3001**\u8e8a\u8e87\u306a\u304f\u901f\u3084\u304b\u306a\u30a4\u30f3\u30b9\u30ea\u30f3\u6cbb\u7642\u3078\u306e\u5909\u66f4\uff08\u307e\u305f\u306f\u5f37\u5316\uff09**\u3092\u884c\u3063\u3066\u304f\u3060\u3055\u3044\u3002\u3053\u308c\u304c\u3001\u5b8c\u5168\u306a\u30a4\u30f3\u30b9\u30ea\u30f3\u4f9d\u5b58\u72b6\u614b\u3078\u306e\u79fb\u884c\u3092\u98df\u3044\u6b62\u3081\u308b\u305f\u3081\u306e\u6700\u7d42\u7684\u306a\u4ecb\u5165\u95be\u5024\u3068\u306a\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u9577\u671f\u7684\u5408\u4f75\u75c7\u8a55\u4fa1\uff1a<\/strong> \u4e2d\u9577\u671f\u7684\u306a\u8996\u70b9\u304b\u3089\u3001\u7db2\u819c\u75c7\u3084\u814e\u75c7\u306a\u3069\u306e\u8840\u7ba1\u5408\u4f75\u75c7\u306e\u9032\u5c55\u8a55\u4fa1\u3092\u4e26\u884c\u3057\u3066\u5b9f\u65bd\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/li>\n<\/ol>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n\n\n\n<p><strong>6. <\/strong><strong>\u4fdd\u967a\u8a3a\u7642\u4e0a\u306e\u5bfe\u5fdc\u3068\u904b\u7528\u306e\u5b9f\u969b<\/strong><\/p>\n\n\n\n<p>\u65e5\u672c\u56fd\u5185\u3067\u306e\u5b9f\u52d9\u4e0a\u3001SPIDDM\uff08probable\uff09\u306e\u7ba1\u7406\u306b\u306f\u5236\u5ea6\u9762\u3078\u306e\u914d\u616e\u304c\u4e0d\u53ef\u6b20\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u75c5\u540d\u306e\u904b\u7528\u306e\u73fe\u72b6\uff1a<\/strong> \u73fe\u5728\u3001DPP-4\u963b\u5bb3\u85ac\u3084\u30d3\u30b0\u30a2\u30ca\u30a4\u30c9\u85ac\u306f\u3001\u4fdd\u967a\u8a3a\u7642\u4e0a\u306e\u300c1\u578b\u7cd6\u5c3f\u75c5\u300d\u75c5\u540d\u306b\u5bfe\u3057\u3066\u9069\u7528\u304c\u3042\u308a\u307e\u305b\u3093\u3002\u305d\u306e\u305f\u3081\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u975e\u4f9d\u5b58\u72b6\u614b\u3067\u3042\u308bprobable\u4f8b\u306b\u5bfe\u3057\u3066\u3053\u308c\u3089\u306e\u85ac\u5264\u3092\u51e6\u65b9\u3059\u308b\u969b\u306f\u3001<strong>\u66ab\u5b9a\u7684\u306a\u5fc5\u8981\u7f6e\u7f6e\u3068\u3057\u3066\u300cNIDDM\uff082\u578b\u7cd6\u5c3f\u75c5\uff09\u300d\u306e\u75c5\u540d\u3092\u4f75\u8a18\u3059\u308b\u306a\u3069\u306e\u5bfe\u5fdc<\/strong>\u304c\u6c42\u3081\u3089\u308c\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u4eca\u5f8c\u306e\u8ab2\u984c\uff1a<\/strong> \u300c\u7de9\u5f90\u9032\u884c1\u578b\u7cd6\u5c3f\u75c5\u7591\u3044\u300d\u3068\u3044\u3046\u9069\u5207\u306a\u75c5\u540d\u3067\u3001\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u3042\u308b\u85ac\u5264\u304c\u5186\u6ed1\u306b\u4f7f\u7528\u3067\u304d\u308b\u3088\u3046\u3001\u5be9\u67fb\u4f53\u5236\u3084\u5236\u5ea6\u306e\u6574\u5099\u306b\u3064\u3044\u3066\u4eca\u5f8c\u3082\u8b70\u8ad6\u3092\u7d99\u7d9a\u3057\u3066\u3044\u304f\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n\n\n\n<p><strong>7. <\/strong><strong>\u7dcf\u62ec\uff1a\u81b5\u03b2\u7d30\u80de\u4fdd\u8b77\u3092\u6700\u5927\u5316\u3059\u308b\u30de\u30cd\u30b8\u30e1\u30f3\u30c8<\/strong><\/p>\n\n\n\n<p>SPIDDM\uff08probable\uff09\u306e\u7ba1\u7406\u306b\u304a\u3051\u308b\u81f3\u4e0a\u547d\u984c\u306f\u3001**\u300c\u5185\u56e0\u6027\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u80fd\u306e\u67af\u6e07\uff08C\u30da\u30d7\u30c1\u30c9 &lt; 0.6 ng\/mL\uff09\u3092\u3044\u304b\u306b\u9045\u3089\u305b\u3001\u60a3\u8005\u306eQOL\u3092\u7dad\u6301\u3059\u308b\u304b\u300d**\u306b\u3042\u308a\u307e\u3059\u30022023\u5e74\u306e\u6539\u8a02\u8a3a\u65ad\u57fa\u6e96\u3092\u6b66\u5668\u306b\u3001\u78ba\u5b9a\u8a3a\u65ad\u524d\u306e\u300c\u7591\u3044\u300d\u6bb5\u968e\u304b\u3089\u6226\u7565\u7684\u306b\u4ecb\u5165\u3059\u308b\u3053\u3068\u304c\u3001\u9577\u671f\u4e88\u5f8c\u3092\u5de6\u53f3\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u67d4\u8edf\u306a\u85ac\u5264\u9078\u629e\u3068\u3001\u4e00\u8ee2\u3057\u3066\u53b3\u683c\u306a\u5206\u6ccc\u80fd\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u3068\u3044\u3046\u4e8c\u6bb5\u69cb\u3048\u306e\u30de\u30cd\u30b8\u30e1\u30f3\u30c8\u3053\u305d\u304c\u3001\u5c06\u6765\u7684\u306a\u30a4\u30f3\u30b9\u30ea\u30f3\u4f9d\u5b58\u72b6\u614b\u3078\u306e\u9032\u884c\u6291\u5236\u306b\u76f4\u7d50\u3059\u308b\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p><strong>\u25a0 \u4e3b\u8981\u306a\u63a8\u5968\u4e8b\u9805<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>SU<\/strong><strong>\u85ac\u306e\u4f7f\u7528\u306f\u3001\u6297\u539f\u63d0\u793a\u3092\u4fc3\u9032\u3057\u03b2\u7d30\u80de\u7834\u58ca\u3092\u52a0\u901f\u3055\u305b\u308b\u6050\u308c\u304c\u3042\u308b\u305f\u3081\u3001\u53b3\u306b\u907f\u3051\u308b\u3053\u3068\u3002<\/strong><\/li>\n\n\n\n<li><strong>\u85ac\u5264\u9078\u629e\u306f\u3001\u30ab\u30c6\u30b4\u30ea\u30fc\u2460\u306b\u5206\u985e\u3055\u308c\u308bDPP-4\u963b\u5bb3\u85ac\u3001BG\u85ac\u3001\u307e\u305f\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u7642\u6cd5\u3092\u512a\u5148\u3059\u308b\u3053\u3068\u3002<\/strong><\/li>\n\n\n\n<li><strong>\u7a7a\u8179\u6642C\u30da\u30d7\u30c1\u30c9\u6e2c\u5b9a\u3092\u5b9a\u671f\u8a55\u4fa1\u306b\u7d44\u307f\u8fbc\u307f\u3001HbA1c\u306e\u307f\u3067\u306f\u898b\u3048\u306a\u3044\u300c\u5206\u6ccc\u80fd\u306e\u4f4e\u4e0b\u50be\u5411\u300d\u3092\u6349\u3048\u308b\u3053\u3068\u3002<\/strong><\/li>\n\n\n\n<li><strong>\u5206\u6ccc\u80fd\u306e\u4f4e\u4e0b\u3092\u8a8d\u3081\u305f\u5834\u5408\u306f\u3001\u901f\u3084\u304b\u306b\u30a4\u30f3\u30b9\u30ea\u30f3\u6cbb\u7642\u3078\u306e\u8ee2\u63db\uff08\u307e\u305f\u306f\u8ffd\u52a0\uff09\u3068\u3044\u3046\u6cbb\u7642\u5f37\u5316\u3092\u884c\u3046\u3053\u3068\u3002<\/strong><\/li>\n\n\n\n<li><strong>\u4fdd\u967a\u8a3a\u7642\u4e0a\u306e\u5236\u7d04\uff08IA-2\u6297\u4f53\u6e2c\u5b9a\u5236\u9650\u3084\u75c5\u540d\u904b\u7528\uff09\u3092\u6b63\u3057\u304f\u7406\u89e3\u3057\u3001\u500b\u3005\u306e\u60a3\u8005\u306b\u6700\u9069\u306a\u500b\u5225\u5316\u533b\u7642\u3092\u5b9f\u8df5\u3059\u308b\u3053\u3068\u3002<\/strong><\/li>\n<\/ul>\n<div class=\"powerpress_player\" id=\"powerpress_player_9237\"><audio class=\"wp-audio-shortcode\" id=\"audio-3976-1\" preload=\"none\" style=\"width: 100%;\" controls=\"controls\"><source type=\"audio\/mpeg\" src=\"https:\/\/media.blubrry.com\/3955429\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2026\/03\/80375fbeea5ab39636d84513298585ca.mp3?_=1\" \/><a href=\"https:\/\/media.blubrry.com\/3955429\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2026\/03\/80375fbeea5ab39636d84513298585ca.mp3\">https:\/\/media.blubrry.com\/3955429\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2026\/03\/80375fbeea5ab39636d84513298585ca.mp3<\/a><\/audio><\/div><p class=\"powerpress_links powerpress_links_mp3\" style=\"margin-bottom: 1px !important;\">Podcast: <a href=\"https:\/\/media.blubrry.com\/3955429\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2026\/03\/80375fbeea5ab39636d84513298585ca.mp3\" class=\"powerpress_link_pinw\" target=\"_blank\" title=\"Play in new window\" onclick=\"return powerpress_pinw('https:\/\/plaza.umin.ac.jp\/~OIO\/?powerpress_pinw=3976-podcast');\" rel=\"nofollow\">Play in new window<\/a> | <a href=\"https:\/\/media.blubrry.com\/3955429\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2026\/03\/80375fbeea5ab39636d84513298585ca.mp3\" class=\"powerpress_link_d\" title=\"Download\" rel=\"nofollow\" download=\"80375fbeea5ab39636d84513298585ca.mp3\">Download<\/a><\/p><!--powerpress_player-->","protected":false},"excerpt":{"rendered":"<p>1. \u75c7\u4f8b\u80cc\u666f\uff08\u65e2\u5f80\u6b74\u30fb\u7d4c\u904e\uff09 2. \u73fe\u75c7\uff08\u8eab\u4f53\u6240\u898b\u30fb\u75c7\u72b6\uff09 3. \u691c\u67fb\u6240\u898b 4. \u81e8\u5e8a\u8a3a\u65ad \u3053\u306e\u75c7\u4f8b\u306f\u3001\u6297GAD\u6297\u4f53\u304c\u967d\u6027\u3067\u3042\u308b\u3082\u306e\u306e\u3001\u6700\u7d42\u89b3\u5bdf\u6642\u70b9\u3067\u306e\u7a7a\u8179\u6642\u8840\u6e05C\u30da\u30d7\u30c1\u30c9\u304c0.6 ng\/mL\u4ee5\u4e0a\u3067\u3042\u308a\u3001\u5185\u56e0\u6027\u30a4\u30f3\u30b9\u30ea&#8230;<\/p>\n","protected":false},"author":5,"featured_media":3977,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[20],"tags":[],"class_list":["post-3976","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-podcast"],"jetpack_featured_media_url":"https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2026\/03\/unnamed-1-1-scaled.png","jetpack_shortlink":"https:\/\/wp.me\/p9b6zl-128","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/posts\/3976","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3976"}],"version-history":[{"count":1,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/posts\/3976\/revisions"}],"predecessor-version":[{"id":3979,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/posts\/3976\/revisions\/3979"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/media\/3977"}],"wp:attachment":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3976"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3976"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3976"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}