{"id":3669,"date":"2024-10-12T22:50:49","date_gmt":"2024-10-12T13:50:49","guid":{"rendered":"https:\/\/plaza.umin.ac.jp\/~OIO\/?p=3669"},"modified":"2024-10-12T22:52:53","modified_gmt":"2024-10-12T13:52:53","slug":"%e3%83%af%e3%82%af%e3%83%81%e3%83%b3%e3%81%ae%e3%82%b7%e3%82%a7%e3%83%87%e3%82%a3%e3%83%b3%e3%82%b0%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6%e2%91%a1","status":"publish","type":"post","link":"https:\/\/plaza.umin.ac.jp\/~OIO\/?p=3669","title":{"rendered":"\u30ef\u30af\u30c1\u30f3\u306e\u30b7\u30a7\u30c7\u30a3\u30f3\u30b0\u306b\u3064\u3044\u3066\u2461"},"content":{"rendered":"\n

\u306f\u3058\u3081\u306b<\/h3>\n\n\n\n

\u524d\u56de\u306e\u8a18\u4e8b<\/a>\u3067\u306f\u3001\u4e00\u822c\u7684\u306a\u5f93\u6765\u4f7f\u7528\u3055\u308c\u3066\u304d\u305f\u3068\u3044\u3046\u610f\u5473\u3067\u306e\u30ef\u30af\u30c1\u30f3\u306e\u30b7\u30a7\u30c7\u30a3\u30f3\u30b0\u306e\u4f8b\u3092\u6587\u732e\u3092\u5f15\u7528\u3057\u3066\u8aac\u660e\u3057\u307e\u3057\u305f\u3002\u305d\u3057\u3066\u3001\u30ec\u30d7\u30ea\u30b3\u30f3\u30ef\u30af\u30c1\u30f3\u306b\u5bfe\u3059\u308b\u61f8\u5ff5\u3068\u3057\u3066\u62e1\u6563\u3055\u308c\u3066\u3044\u308b\u300c\u30b7\u30a7\u30c7\u30a3\u30f3\u30b0\u300d\u304c\u5f93\u6765\u4f7f\u7528\u3055\u308c\u3066\u3044\u305f\u306e\u3068\u306f\u9055\u3046\u610f\u5473\u3060\u3068\u3044\u3046\u70b9\u3001\u6839\u62e0\u3068\u3055\u308c\u308bSeneff\u6c0f\u306e\u6587\u732e\u306f\u76f4\u63a5\u306e\u6839\u62e0\u3092\u793a\u3055\u305a\u3001\u5f15\u7528\u6587\u732e\u3092\u5f15\u3044\u3066\u3044\u308b\u306e\u307f\u3060\u3068\u3044\u3046\u4e8b\u3092\u8a18\u8f09\u3057\u307e\u3057\u305f\u3002\u4eca\u56de\u306e\u8a18\u4e8b\u3067\u306fSeneff\u6c0f\u304c\u6839\u62e0\u3068\u3057\u3066\u5f15\u7528\u3057\u3066\u3044\u308bLucchetti\u6c0f\u306e\u8ad6\u6587\uff08Lucchetti et al., 2021\uff09\u3092\u898b\u3066\u3086\u304d\u307e\u3059\u3002<\/p>\n\n\n\n

\u30bf\u30a4\u30c8\u30eb<\/h3>\n\n\n\n

Detection and characterisation of extracellular vesicles in exhaled breath condensate and sputum of COPD and severe asthma patients<\/p>\n\n\n\n

\u76f4\u8a33\u3059\u308b\u3068\u300cCOPD\u304a\u3088\u3073\u91cd\u75c7\u5598\u606f\u60a3\u8005\u306e\u547c\u6c17\u51dd\u7e2e\u6db2\u304a\u3088\u3073\u75f0\u4e2d\u306e\u7d30\u80de\u5916\u5c0f\u80de\u306e\u691c\u51fa\u3068\u7279\u6027\u8a55\u4fa1\u300d<\/p>\n\n\n\n

\u30bf\u30a4\u30c8\u30eb\u3092\u898b\u307e\u3059\u3068\u3001mRNA\u30ef\u30af\u30c1\u30f3\u306e\u4f55\u304b\u3092\u8ad6\u3058\u3066\u3044\u308b\u3082\u306e\u3068\u306f\u8aad\u307f\u53d6\u308c\u307e\u305b\u3093\u3002\u30bf\u30a4\u30c8\u30eb\u3060\u3051\u307f\u3066\u3082\u6162\u6027\u9589\u585e\u6027\u80ba\u75be\u60a3\u3042\u308b\u3044\u306f\u91cd\u75c7\u305c\u3093\u305d\u304f\u60a3\u8005\u306e\u547c\u6c17\u3084\u5580\u75f0\u306b\u7d30\u80de\u5916\u5c0f\u80de\u304c\u691c\u51fa\u3067\u304d\u305f\u3068\u3044\u3046\u8a71\u3060\u3068\u308f\u304b\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u30b8\u30e3\u30fc\u30ca\u30eb\u306b\u3064\u3044\u3066<\/h3>\n\n\n\n

Lucchetti\u6c0f\u306e\u8ad6\u6587\uff08Lucchetti et al., 2021\uff09\u306e\u63b2\u8f09\u3055\u308c\u3066\u3044\u307e\u3059Europian Respiratory Journal\u306f\u76f4\u8fd1\u306e\u30a4\u30f3\u30d1\u30af\u30c8\u30d5\u30a1\u30af\u30bf\u30fc\u304c16.6\u3068\u4e00\u6d41\u96d1\u8a8c\u3068\u3044\u3046\u4e8b\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n

\u30d4\u30a2\u30ec\u30d3\u30e5\u30fc\u304b<\/h3>\n\n\n\n

\u5b66\u8853\u96d1\u8a8c\u306e\u8a18\u4e8b\u306b\u306f\u3001\u8ad6\u6587\u304c\u5c02\u9580\u5bb6\u306b\u3088\u3063\u3066\u67fb\u8aad\u3055\u308c\u3066\u5f8c\u306b\u4e16\u306b\u51fa\u308b\u30d4\u30a2\u30ec\u30d3\u30e5\u30fc\u8a8c\u3068\u305d\u3046\u3067\u306a\u3044\u975e\u30d4\u30a2\u30ec\u30d3\u30e5\u30fc\u8a8c\u304c\u3042\u308a\u307e\u3059\u3002\u300c\u30d4\u30a2\u30ec\u30d3\u30e5\u30fc\u8a8c\u300d\u306e\u4e2d\u306b\u3082\u5c02\u9580\u5bb6\u306b\u3088\u3063\u3066\u67fb\u8aad\u3055\u308c\u308b\u8a18\u4e8b\u3068\u305d\u3046\u3067\u306a\u3044\u8a18\u4e8b\u304c\u3042\u308a\u307e\u3059\u3002\u8a73\u3057\u304f\u306f\u5404\u96d1\u8a8c\u306e\u6295\u7a3f\u898f\u5b9a\u3092\u898b\u308b\u3068\u66f8\u304b\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u300c\u30aa\u30ea\u30b8\u30ca\u30eb\u30a2\u30fc\u30c6\u30a3\u30af\u30eb\u300d\u306f\u901a\u5e38\u30d4\u30a2\u30ec\u30d3\u30e5\u30fc\u306e\u8a18\u4e8b\u306b\u306a\u308a\u307e\u3059\u3002\u4e00\u65b9\u3001\u300c\u30a8\u30c7\u30a3\u30c8\u30ea\u30a2\u30eb\u300d\u3068\u547c\u3070\u308c\u308b\u3001\u5f53\u8a72\u96d1\u8a8c\u306b\u63b2\u8f09\u3055\u308c\u305f\u30aa\u30ea\u30b8\u30ca\u30eb\u30a2\u30fc\u30c6\u30a3\u30af\u30eb\u306e\u7d39\u4ecb\u6587\u3084\u7de8\u96c6\u8005\u304b\u3089\u306e\u30e1\u30c3\u30bb\u30fc\u30b8\u3001\u305d\u308c\u306b\u3001\u8a02\u6b63\u306e\u304a\u77e5\u3089\u305b\u306a\u3069\u306f\u30d4\u30a2\u30ec\u30d3\u30e5\u30fc\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u5c02\u9580\u5bb6\u540c\u58eb\u306e\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3\u3067\u3042\u308b\u3001\u30ec\u30bf\u30fc\u3084\u30b7\u30e7\u30fc\u30c8\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3\u306f\u30d4\u30a2\u30ec\u30d3\u30e5\u30fc\u3092\u5b9f\u65bd\u3059\u308b\u96d1\u8a8c\u3068\u305d\u3046\u3067\u306a\u3044\u96d1\u8a8c\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u30d4\u30a2\u30ec\u30d3\u30e5\u30fc\u3092\u5b9f\u65bd\u3057\u306a\u3044\u96d1\u8a8c\u3067\u3082\u7de8\u96c6\u8005\u304c\u76ee\u3092\u901a\u3057\u3066\u4e00\u5b9a\u306e\u57fa\u6e96\u3092\u6e80\u305f\u3057\u305f\u3082\u306e\u304c\u63b2\u8f09\u3055\u308c\u308b\u3053\u3068\u304c\u591a\u3044\u306f\u305a\u3067\u3059\u3002<\/p>\n\n\n\n

\u3053\u306eLucchetti\u6c0f\u306e\u8ad6\u6587\u306fResearch Letter\u306e\u8a18\u4e8b\u3067\u3001\u8a18\u4e8b\u306e\u30dc\u30ea\u30e5\u30fc\u30e0\u3084\u30c7\u30fc\u30bf\u304c\u3057\u3063\u304b\u308a\u793a\u3055\u308c\u3066\u8ad6\u8ff0\u3057\u3066\u3044\u308b\u3068\u3053\u308d\u304b\u3089\u306f\u30d4\u30a2\u30ec\u30d3\u30e5\u30fc\u3092\u53d7\u3051\u3066\u4e16\u306b\u51fa\u3055\u308c\u305f\u3082\u306e\u3060\u3068\u601d\u308f\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

\u8ad6\u6587\u306e\u6982\u8981<\/h3>\n\n\n\n

\u4ee5\u4e0b\u304c\u5f53\u8a72\u8ad6\u6587\u306e\u6982\u8981\u3067\u3059\uff1a<\/p>\n\n\n\n

    \n
  • \u7814\u7a76\u76ee\u7684<\/strong>\uff1aEBC\uff08\u547c\u6c17\u51dd\u7e2e\u6db2\uff09\u304a\u3088\u3073\u75f0\u4e2d\u306e\u7d30\u80de\u5916\u5c0f\u80de\u306e\u7dcf\u30bf\u30f3\u30d1\u30af\u8cea\u542b\u91cf\u3092\u6e2c\u5b9a\u3057\u3001\u7d30\u80de\u5916\u5c0f\u80de\u306e\u6570\u3092\u9593\u63a5\u7684\u306b\u8a55\u4fa1\u3002<\/li>\n\n\n\n
  • \u5bfe\u8c61\u8005<\/strong>\uff1a\u91cd\u75c7\u5598\u606f\u60a3\u800520\u540d\u3001COPD\u60a3\u800535\u540d\u3001\u5065\u5eb7\u306a\u5bfe\u7167\u800510\u540d\u3002<\/li>\n\n\n\n
  • \u6e2c\u5b9a\u9805\u76ee<\/strong>\uff1a\u30b9\u30d1\u30a4\u30ed\u30e1\u30c8\u30ea\u30fc\u3001FENO\u6e2c\u5b9a\u3001EBC\u53ce\u96c6\u3001\u75f0\u8a98\u767a\u3002<\/li>\n\n\n\n
  • \u7d50\u679c<\/strong>\uff1a\n
      \n
    • EBC\u4e2d\u306e\u5c0f\u578b\u7d30\u80de\u5916\u5c0f\u80de\uff08sEV\uff09\u30bf\u30f3\u30d1\u30af\u8cea\u6fc3\u5ea6\u306f\u3001\u91cd\u75c7\u5598\u606f\u60a3\u8005\u3067\u6700\u3082\u9ad8\u3044\u3002<\/li>\n\n\n\n
    • EBC\u4e2d\u306e\u4e2d\u578b\u7d30\u80de\u5916\u5c0f\u80de\uff08mEV\uff09\u30bf\u30f3\u30d1\u30af\u8cea\u6fc3\u5ea6\u306f\u3001COPD\u60a3\u8005\u3067\u6700\u3082\u9ad8\u3044\u3002<\/li>\n\n\n\n
    • \u75f0\u4e0a\u6e05\u304b\u3089\u5206\u96e2\u3055\u308c\u305fsEV\u304a\u3088\u3073mEV\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u6fc3\u5ea6\u306f\u3001\u91cd\u75c7\u5598\u606f\u60a3\u8005\u3068COPD\u60a3\u8005\u3067\u985e\u4f3c\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n
    • \u7d50\u8ad6<\/strong>\uff1a\n
        \n
      • EBC\u306f\u3001\u91cd\u75c7\u5598\u606f\u3068COPD\u60a3\u8005\u9593\u306e\u7d30\u80de\u5916\u5c0f\u80de\u306e\u5b9a\u91cf\u7684\u5dee\u7570\u3092\u7814\u7a76\u3059\u308b\u305f\u3081\u306e\u6709\u7528\u306a\u751f\u4f53\u6db2\u3067\u3042\u308b\u53ef\u80fd\u6027\u3002<\/li>\n\n\n\n
      • EBC sEV\u304a\u3088\u3073mEV\u304b\u3089DNA\u3092\u5206\u96e2\u3067\u304d\u3001\u80ba\u75be\u60a3\u306e\u907a\u4f1d\u5b50\u89e3\u6790\u306b\u9069\u3057\u305f\u6838\u9178\u306e\u4f9b\u7d66\u6e90\u3068\u306a\u308b\u53ef\u80fd\u6027\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n
      • \u4eca\u5f8c\u306e\u8ab2\u984c<\/strong>\uff1a\u7d30\u80de\u5916\u5c0f\u80de\u306e\u5185\u5bb9\u7269\u3092\u5b9a\u91cf\u5316\u3057\u3001\u6642\u9593\u7d4c\u904e\u306b\u3088\u308b\u5909\u52d5\u6027\u3084\u6f5c\u5728\u7684\u306a\u4ea4\u7d61\u56e0\u5b50\u3092\u660e\u78ba\u306b\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002<\/li>\n<\/ul>\n\n\n\n

        \u8a18\u4e8b\u306fmRNA\u30ef\u30af\u30c1\u30f3\u306e\u30b7\u30a7\u30c7\u30a3\u30f3\u30b0\u3092\u8ad6\u3058\u3066\u3044\u308b\u304b<\/h3>\n\n\n\n

        \u4e0a\u8a18\u306e\u901a\u308aLucchetti\u6c0f\u306e\u8ad6\u6587\u306f\u6162\u6027\u9589\u585e\u6027\u80ba\u75be\u60a3\uff08COPD\uff09\u304b\u91cd\u75c7\u5598\u606f\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u3066\u3044\u3066\u3001mRNA\u30ef\u30af\u30c1\u30f3\u306e\u63a5\u7a2e\u306e\u6709\u7121\u306f\u554f\u984c\u306b\u3057\u3066\u3044\u307e\u305b\u3093\u3002\u76f4\u5f8420-1000nm\u307b\u3069\u306e\u5c0f\u578b\u306e\u819c\u3067\u8986\u308f\u308c\u305f\u5c0f\u80de\u306e\u4e8b\u3092\u554f\u984c\u306b\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306e\u30b5\u30a4\u30ba100nm\u4ed8\u8fd1\u306b\u8fd1\u3044\u30ec\u30f3\u30b8\u3067\u3001\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\uff0810nm\u307b\u3069\u304b\uff1f\uff09\u306f\u8b70\u8ad6\u306b\u51fa\u3066\u304d\u3066\u3044\u307e\u305b\u3093\u3002\u5c11\u306a\u304f\u3068\u3082\u76f4\u63a5\u7684\u306bmRNA\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\u30d2\u30c8\u304b\u3089\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u304c\u653e\u51fa\u3055\u308c\u308b\u3068\u3044\u3046\u4e8b\u3092\u793a\u3057\u305f\u3068\u3044\u3046\u8a71\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n

        \u307e\u3068\u3081<\/h3>\n\n\n\n

        \u79c1\u306e\u8aad\u307f\u89e3\u3044\u305f\u3068\u3053\u308d\u3067\u306f\u3001Lucchetti\u6c0f\u306e\u8ad6\u6587\u306f\u666e\u901a\u306e\u5b66\u8853\u8ad6\u6587\u3067\u3001\u4e00\u6d41\u7d19\u3067\u8ad6\u3058\u3089\u308c\u305f\u79d1\u5b66\u7684\u306a\u77e5\u898b\u3067\u3042\u308b\u304c\u3001\u305d\u308c\u306fmRNA\u30ef\u30af\u30c1\u30f3\u306e\u30b7\u30a7\u30c7\u30a3\u30f3\u30b0\u3092\u61f8\u5ff5\u3059\u308b\u3068\u3044\u3046\u30c7\u30fc\u30bf\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3053\u306e\u90e8\u8ad6\u6587\u3092\u5f15\u7528\u3057\u305fSeneff\u6c0f\u304c\u6301\u8ad6\u306b\u90fd\u5408\u826f\u3044\u3088\u3046\u306b\u66f2\u89e3\u3057\u3066\u3044\u308b\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

        References<\/h3>\n\n\n\n

        Lucchetti, D., Santini, G., Perelli, L., Ricciardi-Tenore, C., Colella, F., Mores, N., Macis, G., Bush, A., Sgambato, A., & Montuschi, P. (2021). Detection and characterisation of extracellular vesicles in exhaled breath condensate and sputum of COPD and severe asthma patients<\/em>. 58<\/em>(2), 2003024. https:\/\/doi.org\/10.1183\/13993003.03024-2020<\/p>\n\n\n\n

        <\/p>\n","protected":false},"excerpt":{"rendered":"

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