{"id":3529,"date":"2024-05-17T17:23:00","date_gmt":"2024-05-17T08:23:00","guid":{"rendered":"https:\/\/plaza.umin.ac.jp\/~OIO\/?p=3529"},"modified":"2024-05-28T17:42:15","modified_gmt":"2024-05-28T08:42:15","slug":"role-of-gm-csf-in-lung-balance-and-ild","status":"publish","type":"post","link":"https:\/\/plaza.umin.ac.jp\/~OIO\/?p=3529","title":{"rendered":"Role of GM-CSF in lung balance and ILD"},"content":{"rendered":"\n

\u30bf\u30a4\u30c8\u30eb\u3068\u540c\u540d\u306e\u6587\u732e\u306e\u4e00\u90e8\u3092\u7d39\u4ecb\u200b1\u200b<\/sup><\/span>\u3002\u3053\u306e\u8ad6\u6587\u306f\u3001\u9846\u7c92\u7403\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8 \u30b3\u30ed\u30cb\u30fc\u523a\u6fc0\u56e0\u5b50 (GM-CSF) \u306f\u3001\u3082\u3068\u3082\u3068\u9aa8\u9ac4\u524d\u99c6\u7d30\u80de\u306e\u9846\u7c92\u7403\u3068\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3078\u306e\u5206\u5316\u3092\u8a98\u5c0e\u3059\u308b\u523a\u6fc0\u7269\u3068\u3057\u3066\u540c\u5b9a\u3055\u308c\u305f\u9020\u8840\u5897\u6b96\u56e0\u5b50\u3067\u3059\u3002 GM-CSF \u306f\u73fe\u5728\u3001\u591a\u8d77\u6e90\u306e\u591a\u9762\u767a\u73fe\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002 GM-CSF \u53d7\u5bb9\u4f53\u30b7\u30b0\u30ca\u30eb\u306f JAK2 \u3092\u6d3b\u6027\u5316\u3057\u3001JAK-STAT\u3001MAPK\u3001PI3K\u3001\u304a\u3088\u3073\u305d\u306e\u4ed6\u306e\u7d4c\u8def\u3092\u901a\u3058\u3066\u6838\u30b7\u30b0\u30ca\u30eb\u3092\u8a98\u5c0e\u3057\u307e\u3059\u3002\u80ba\u30b5\u30fc\u30d5\u30a1\u30af\u30bf\u30f3\u30c8\u306e\u4ee3\u8b1d\u3068\u80ba\u80de\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306e\u6210\u719f\u3068\u5206\u5316\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u306b\u52a0\u3048\u3066\u3001GM-CSF \u306f\u9593\u8cea\u6027\u80ba\u75be\u60a3\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u80ba\u75be\u60a3\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u80ba\u75be\u60a3\u3001\u80ba\u306e\u7d30\u83cc\u3001\u771f\u83cc\u3001\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

\u30b5\u30fc\u30d5\u30a1\u30af\u30bf\u30f3\u30c8\u3068GM-CSF\u306b\u3088\u308b\u754c\u9762\u6d3b\u6027\u306e\u6052\u5e38\u6027<\/h2>\n\n\n\n

\u80ba\u30b5\u30fc\u30d5\u30a1\u30af\u30bf\u30f3\u30c8\u306f\u3001\u7d04 90% \u306e\u8102\u8cea\u3068 10% \u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u69cb\u6210\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u8102\u8cea\u306e\u7d04 80 \uff5e 90% \u306f\u30ea\u30f3\u8102\u8cea\u3067\u3001\u754c\u9762\u6d3b\u6027\u5264\u95a2\u9023\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u306f SP-A\u3001SP-B\u3001SP-C\u3001\u304a\u3088\u3073 SP-D \u304c\u542b\u307e\u308c\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u30ea\u30f3\u8102\u8cea\u6210\u5206\u306e\u7d30\u80de\u5185\u8f38\u9001\u306b\u95a2\u4e0e\u3057\u3001\u80ba\u80de\u306b\u304a\u3051\u308b\u754c\u9762\u6d3b\u6027\u5264\u7279\u6027\u306e\u7dad\u6301\u306b\u5bc4\u4e0e\u3057\u307e\u3059 \u200b2,3\u200b<\/sup><\/span>\u3002\u754c\u9762\u6d3b\u6027\u5264\u306e\u30ea\u30f3\u8102\u8cea\u3068\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u2161\u578b\u80ba\u80de\u4e0a\u76ae\u7d30\u80de(AT2<\/a>)\u306b\u3088\u3063\u3066\u5408\u6210\u3055\u308c\u3001\u5206\u6ccc\u3055\u308c\u307e\u3059\u200b4,5\u200b<\/sup><\/span> \u3002\u754c\u9762\u6d3b\u6027\u5264\u306f\u6c17\u6db2\u754c\u9762\u3067\u5358\u5c64\u304a\u3088\u3073\u591a\u5c64\u3092\u5f62\u6210\u3057\u3066\u8868\u9762\u5f35\u529b\u3092\u4f4e\u4e0b\u3055\u305b\u3001\u80ba\u80de\u306e\u5d29\u58ca\u3092\u9632\u304e\u307e\u3059\u3002\u754c\u9762\u6d3b\u6027\u5264\u306f\u3001\u6a5f\u68b0\u7684\u307e\u305f\u306f\u751f\u7269\u5b66\u7684\u4f5c\u7528\u306b\u3088\u3063\u3066\u4e0d\u6d3b\u6027\u306a\u5c0f\u3055\u306a\u51dd\u96c6\u7c92\u5b50\u3068\u306a\u308a\u3001AT2\u304a\u3088\u3073 \u80ba\u80de\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8(AM) \u306b\u3088\u3063\u3066\u5438\u53ce\u3001\u518d\u5229\u7528\u3001\u307e\u305f\u306f\u5206\u89e3\u3055\u308c\u307e\u3059\u200b6\u200b<\/sup><\/span> \u3002<\/p>\n\n\n\n

GM-CSF\u6b20\u640d\u30de\u30a6\u30b9\u306b\u304a\u3051\u308b\u4ee3\u8b1d\u7814\u7a76\u3067\u306f\u3001GM-CSF\u6b20\u640d\u30de\u30a6\u30b9\u306e\u80ba\u80de\u306b\u304a\u3051\u308b\u754c\u9762\u6d3b\u6027\u5264\u306e\u84c4\u7a4d\u306f\u3001GM-CSF\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u6b20\u5982\u304c\u754c\u9762\u6d3b\u6027\u5264\u306e\u7570\u5316\u4f5c\u7528\u3092\u640d\u306a\u3046\u4e00\u65b9\u3001\u754c\u9762\u6d3b\u6027\u5264\u306e\u7570\u5316\u4f5c\u7528\u304c\u640d\u306a\u308f\u308c\u306a\u3044\u3053\u3068\u304c\u539f\u56e0\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002\u305d\u306e\u30ea\u30f3\u8102\u8cea\u304a\u3088\u3073\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5408\u6210\u307e\u305f\u306f\u5206\u6ccc\u3092\u76f4\u63a5\u5909\u66f4\u3057\u307e\u3059\u200b7\u200b<\/sup><\/span> \u3002 GM-CSF\u6b20\u640d\u30de\u30a6\u30b9\u304b\u3089\u5358\u96e2\u3055\u308c\u305fAM\u306ein vitro<\/em>\u7814\u7a76\u3067\u306f\u3001SP-A\u304a\u3088\u3073\u754c\u9762\u6d3b\u6027\u5264\u30ea\u30f3\u8102\u8cea\u306e\u7570\u5316\u306b\u304a\u3051\u308b\u91cd\u5927\u306a\u6b20\u9665\u3001\u306a\u3089\u3073\u306bAM\u306b\u3088\u308bSP-A\u304a\u3088\u3073DPPC\u306e\u5206\u89e3\u306e\u9855\u8457\u306a\u6e1b\u5c11\u304c\u78ba\u8a8d\u3055\u308c\u305f\u200b8\u200b<\/sup><\/span>\u3002\u3055\u3089\u306b\u3001\u80ba\u306b\u304a\u3051\u308b GM-CSF \u767a\u73fe\u304c\u5897\u52a0\u3057\u305f\u30de\u30a6\u30b9\u306f\u3001AM \u306b\u304a\u3051\u308b\u30b5\u30fc\u30d5\u30a1\u30af\u30bf\u30f3\u30c8\u7570\u5316\u901f\u5ea6\u306e\u5897\u52a0\u3092\u793a\u3057\u307e\u3059\u304c\u3001GM-CSF \u6b20\u640d\u30de\u30a6\u30b9 AM \u306b\u3088\u308b\u30b5\u30fc\u30d5\u30a1\u30af\u30bf\u30f3\u30c8\u6210\u5206\u306e\u53d6\u308a\u8fbc\u307f\u306f\u59a8\u3052\u3089\u308c\u307e\u305b\u3093\u200b7\u200b<\/sup><\/span> \u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001GM-CSF\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u304c\u5b58\u5728\u3057\u306a\u3044\u5834\u5408\u3001\u754c\u9762\u6d3b\u6027\u5264\u306e\u30db\u30e1\u30aa\u30b9\u30bf\u30b7\u30b9\u306b\u304a\u3051\u308b\u4e3b\u306a\u6b20\u9665\u306f\u3001AM\u306b\u3088\u308b\u754c\u9762\u6d3b\u6027\u5264\u30bf\u30f3\u30d1\u30af\u8cea\u304a\u3088\u3073\u8102\u8cea\u306e\u7570\u5316\u4f5c\u7528\u304c\u4e0d\u5341\u5206\u3067\u3042\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u304a\u308a\u200b7\u200b<\/sup><\/span>\u3001\u3053\u308c\u306f\u3001\u7d30\u80de\u306e\u5897\u6b96\u306e\u305f\u3081\u306bAT2\u304b\u3089\u306eGM-CSF\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u304c\u5fc5\u8981\u3067\u3042\u308b\u3053\u3068\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002 AM \u306e\u958b\u767a\u3068\u5206\u5316\u3002\u3053\u308c\u306f\u3001AT2 \u3068 AM \u306e\u9593\u306b\u76f8\u4e92\u306b\u6709\u76ca\u306a\u5171\u751f\u95a2\u4fc2\u304c\u3042\u308b\u3053\u3068\u3082\u793a\u3057\u3066\u3044\u307e\u3059\u3002 AT2 \u7531\u6765 GM-CSF \u306f\u3001PU.1 \u304a\u3088\u3073 PPAR-\u03b3 \u306e\u767a\u73fe\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u3067 AM \u306e\u767a\u751f\u3092\u8a98\u5c0e\u3057\u307e\u3059\u3002\u6b21\u306b\u3001\u6210\u719f\u3057\u305f AM \u306f\u3001AT2 \u306b\u3088\u3063\u3066\u751f\u6210\u3055\u308c\u308b\u754c\u9762\u6d3b\u6027\u5264\u3092\u5206\u89e3\u3057\u3001\u80ba\u80de\u74b0\u5883\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u7dad\u6301\u3059\u308b\u305f\u3081\u306b\u4e0d\u53ef\u6b20\u3067\u3059 (\u56f32<\/strong><\/a>\uff09\u3002<\/p>\n\n\n\n

\"CCBY<\/figure>\n\n\n\n

CCBY Chen, Li, Hua, Liang, Song\u200b1\u200b<\/sup><\/span><\/p>\n\n\n\n

GM-CSF\u3068\u9593\u8cea\u6027\u80ba\u75be\u60a3<\/h2>\n\n\n\n

\u9593\u8cea\u6027\u80ba\u75be\u60a3 (ILD) \u306b\u306f\u3001\u80ba\u5b9f\u8cea\u306e\u708e\u75c7\u3068\u7dda\u7dad\u75c7\u3092\u7279\u5fb4\u3068\u3059\u308b\u4e00\u7fa4\u306e\u4e0d\u5747\u4e00\u6027\u80ba\u75be\u60a3\u304c\u542b\u307e\u308c\u307e\u3059\u3002 GM-CSF \u306f\u80ba\u7dda\u7dad\u75c7\u306e\u9032\u884c\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u6c17\u7ba1\u652f\u80ba\u80de\u6d17\u6d44\u6db2\u4e2d\u306e GM-CSF \u7523\u751f\u306f\u3001\u80ba\u7dda\u7dad\u75c7\u60a3\u8005\u3067\u5897\u52a0\u3057\u307e\u3059 \u200b9\u200b<\/sup><\/span>\u3002 GM-CSF\u306f\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3092\u523a\u6fc0\u3057\u3066\u7dda\u7dad\u5316\u4fc3\u9032<\/a>\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u7523\u751f\u3055\u305b\u3001\u6c17\u9053\u5e73\u6ed1\u7b4b\u7d30\u80de\u306e\u7dda\u7dad\u5316\u3092\u76f4\u63a5\u8a98\u5c0e\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u200b10,11\u200b<\/sup><\/span> \u3002\u81ea\u5df1\u514d\u75ab\u307e\u305f\u306f\u708e\u75c7\u6a5f\u69cb\u306f\u3001ILD \u306b\u95a2\u9023\u3059\u308b\u7d50\u5408\u7d44\u7e54\u75c5 ( CTD<\/a> – ILD) \u306e\u75c5\u56e0\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u4e2d\u5fc3\u7684\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u200b12,13\u200b<\/sup><\/span> \u3002<\/a><\/a><\/a><\/p>\n\n\n\n

\u81ea\u5df1\u514d\u75ab\u6027\u95a2\u7bc0\u708e\u306e\u30e2\u30c7\u30eb\u3067\u3042\u308b SKG \u30de\u30a6\u30b9\u3092\u9175\u6bcd\u591a\u7cd6\u985e\u3067\u6cbb\u7642\u3059\u308b\u3068\u3001\u6162\u6027\u9032\u884c\u6027 ILD \u304c\u767a\u75c7\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u30de\u30a6\u30b9\u306f\u3001\u80ba\u7dda\u7dad\u75c7\u3092\u4f34\u3046\u3001Th17 \u7d30\u80de\u3001GM-CSF \u7523\u751f CD4+ T \u7d30\u80de\u3001CD11b+Gr1+ \u597d\u4e2d\u7403\u306e\u5927\u91cf\u306e\u80ba\u6d78\u6f64\u3092\u793a\u3057\u307e\u3059\u3002\u30ca\u30a4\u30fc\u30d6 SKG \u30de\u30a6\u30b9 T \u7d30\u80de\u306f GM-CSF \u7523\u751f\u7d30\u80de\u306b\u5206\u5316\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u306f\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u3088\u308bIL-6\u304a\u3088\u3073IL-1\u03b2\u306e\u7523\u751f\u3092\u5897\u5f37\u3057\u3001\u305d\u308c\u306b\u3088\u3063\u3066IL-17A\u304a\u3088\u3073\/\u307e\u305f\u306fGM-CSF\u7523\u751fT\u7d30\u80de\u306e\u5206\u5316\u3068\u80ba\u3078\u306e\u597d\u4e2d\u7403\u306e\u6d78\u6f64\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002 GM-CSF\u306e\u4e2d\u548c\u306fILD\u306e\u767a\u75c7\u3092\u963b\u6b62\u3059\u308b\u304c\u3001IL-17A\u306e\u4e2d\u548c\u306f\u963b\u6b62\u3057\u306a\u3044\u3053\u3068\u304b\u3089\u3001SKG\u30de\u30a6\u30b9\u306b\u304a\u3051\u308bILD\u306e\u767a\u75c7\u306b\u306fIL-17A\u3067\u306f\u306a\u304fGM-CSF\u304c\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u308b\u200b14\u200b<\/sup><\/span>\u3002\u307e\u305f\u3001GM-CSF\u304cILD\u767a\u75c7\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u3053\u3068\u3082\u793a\u3057\u305f\u304c\u3001\u3053\u308c\u3089\u306e\u8457\u8005\u3089\u306f\u3001IL-17A+GM-CSF+\u597d\u4e2d\u7403\u304c\u30ab\u30fc\u30c9\u30e9\u30f3\u51e6\u7406SKG\u30de\u30a6\u30b9\u306e\u80ba\u306b\u6d78\u6f64\u3057\u305f\u4e3b\u306a\u708e\u75c7\u7d30\u80de\u3067\u3042\u308b\u3068\u4fe1\u3058\u3066\u3044\u305f\u200b15\u200b<\/sup><\/span>\u3002<\/p>\n\n\n\n

SKG\u30de\u30a6\u30b9\u306b\u304a\u3051\u308b\u91cd\u5ea6\u306e\u9593\u8cea\u6027\u80ba\u75be\u60a3\u306e\u767a\u75c7\u306b\u306f\u3001IL-17\u3067\u306f\u306a\u304fGM-CSF\u304c\u91cd\u8981\u3067\u3042\u308b\u200b14\u200b<\/sup><\/span><\/h2>\n\n\n\n

\u30b6\u30a4\u30e2\u30b5\u30f3\u3067\u6cbb\u7642\u3057\u305f SKG \u30de\u30a6\u30b9\u306b\u304a\u3051\u308b ILD \u306e\u75c5\u7406\u5b66\u7684\u304a\u3088\u3073\u81e8\u5e8a\u7684\u7279\u5fb4\u306f\u3001\u30d2\u30c8\u306e\u91cd\u5ea6 CTD-ILD \u306e\u7279\u5fb4\u3068\u985e\u4f3c\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u3053\u306e\u30de\u30a6\u30b9\u306e ILD \u306f\u3001Th17 \u7d30\u80de\u3001GM-CSF \u7523\u751f CD4 +<\/sup> T \u7d30\u80de\u3001\u304a\u3088\u3073\u7dda\u7dad\u5316\u3092\u4f34\u3046 CD11b +<\/sup> Gr1 +<\/sup>\u597d\u4e2d\u7403\u306e\u5927\u91cf\u6d78\u6f64\u3092\u7279\u5fb4\u3068\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u30ca\u30a4\u30fc\u30d6 T \u7d30\u80de\u306f GM-CSF \u7523\u751f\u7d30\u80de\u306b\u5206\u5316\u3059\u308b\u3088\u3046\u306b\u504f\u3063\u3066\u304a\u308a\u3001T \u7d30\u80de\u306b\u3088\u3063\u3066\u5206\u6ccc\u3055\u308c\u308b GM-CSF \u306f\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u3088\u308b IL-6 \u304a\u3088\u3073 IL-1\u03b2 \u306e\u7523\u751f\u3092\u5897\u5f37\u3057\u3001\u305d\u306e\u7d50\u679c\u3001IL-17A \u304a\u3088\u3073\/\u307e\u305f\u306f GM \u306e\u5206\u5316\u304c\u5897\u5f37\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Fig4 A SKG T \u7d30\u80de\u306f\u3001IL-17A \u7523\u751f\u7d30\u80de\u3068 GM-CSF \u7523\u751f\u7d30\u80de\u306b\u5206\u5316\u3059\u308b\u3088\u3046\u306b\u504f\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u200b14\u200b<\/sup><\/span><\/p>\n\n\n\n

GM-CSF \u306e\u4e2d\u548c\u306b\u3088\u308a\u3001\u6d78\u6f64\u3057\u305f\u7dcf CD4 +<\/sup> T \u7d30\u80de\uff08\u7279\u306b IL-17A\u3001GM-CSF\u3001\u304a\u3088\u3073 IL-6 \u7523\u751f CD4 +<\/sup> T \u7d30\u80de\uff09\u3001CD11b +<\/sup> Gr1 +<\/sup>\u597d\u4e2d\u7403\u3001\u304a\u3088\u3073 IL- 6 \u2013 CD11b +<\/sup> Gr1 \u2212<\/sup>\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\/\u5358\u7403\u3092\u751f\u6210\u3057\u307e\u3059\u3002\u5bfe\u7167\u7684\u306b\u3001IL-6 \u30b7\u30b0\u30ca\u30eb\u306e\u906e\u65ad\u306b\u3088\u308a\u6e1b\u5c11\u3057\u305f\u306e\u306fCD11b +<\/sup> Gr1 +<\/sup>\u597d\u4e2d\u7403\u306e\u7d30\u80de\u96c6\u56e3\u306e\u307f\u3067\u3042\u308a\u3001IL-17A \u4e2d\u548c\u3067\u306f\u3044\u305a\u308c\u3082\u6e1b\u5c11\u3057\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u6ce8\u76ee\u3059\u3079\u304d\u3053\u3068\u306b\u3001\u4e3b\u8981\u306aGM-CSF\u7523\u751f\u7d30\u80de\u3067\u3042\u308bGM-CSF +<\/sup> IL-17A –<\/sup> CD4 +<\/sup>\u7d30\u80de\u306e\u6570\u306f\u3001GM-CSF\u306e\u4e2d\u548c\u304a\u3088\u3073\u90e8\u5206\u7684\u306bIL-6\u30b7\u30b0\u30ca\u30eb\u306e\u906e\u65ad\u306b\u3088\u3063\u3066\u6e1b\u5c11\u3057\u305f\u3002+<\/sup> IL-17A +<\/sup>\u7d30\u80de\u306f GM-CSF \u4e2d\u548c\u306b\u3088\u3063\u3066\u306e\u307f\u6e1b\u5c11\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u3053\u306e\u30de\u30a6\u30b9\u306e ILD \u3092\u6cbb\u7642\u3059\u308b\u6700\u3082\u5f37\u529b\u306a\u5206\u5b50\u6a19\u7684\u306f GM-CSF \u3067\u3042\u308a\u3001IL-17A\u3001GM-CSF \u7523\u751f CD4 +<\/sup> T \u7d30\u80de\u3001IL-6 \u7523\u751f CD11b +<\/sup> Gr1 –<\/sup>\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306e\u6d78\u6f64\u3067\u3042\u308b\u3053\u3068\u3092\u5b9f\u8a3c\u3057\u307e\u3057\u305f\u3002 \u5358\u7403\u3001\u304a\u3088\u3073CD11b +<\/sup> Gr1 +<\/sup>\u597d\u4e2d\u7403\u306f\u3001\u30b6\u30a4\u30e2\u30b5\u30f3\u51e6\u7406SKG\u30de\u30a6\u30b9\u306b\u304a\u3051\u308bILD\u306e\u767a\u75c7\u306b\u304a\u3044\u3066GM-CSF\u30a2\u30c3\u30d7\u30ec\u30ae\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u306b\u7d9a\u3044\u3066\u9032\u884c\u3057\u3001GM-CSF\u306e\u4e2d\u548c\u306b\u3088\u3063\u3066\u963b\u5bb3\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u305f\u3002<\/p>\n\n\n\n

GM-CSF\u306e\u4e2d\u548c\u306f\u3001ILD\u306e\u767a\u75c7\u5f8c\u3067\u3042\u3063\u3066\u3082\u30b6\u30a4\u30e2\u30b5\u30f3\u51e6\u7f6eSKG\u30de\u30a6\u30b9\u306b\u304a\u3051\u308bILD\u306e\u9032\u884c\u3092\u963b\u5bb3\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001GM-CSF\u306e\u4e2d\u548c\u304c\u30d2\u30c8\u306e\u91cd\u5ea6CTD-ILD\u306e\u6cbb\u7642\u6226\u7565\u3068\u3057\u3066\u9ad8\u3044\u53ef\u80fd\u6027\u3092\u793a\u5506\u3059\u308b\u3002<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Fig 8 SKG\u30de\u30a6\u30b9\u306b\u304a\u3051\u308bILD\u306e\u767a\u75c7\u306b\u304a\u3051\u308bGM-CSF\u306e\u5f79\u5272\u306e\u30e2\u30c7\u30eb\u3002 (\u00a0A<\/strong>\u00a0) \u30b6\u30a4\u30e2\u30b5\u30f3\u51e6\u7406\u3057\u305f BALB\/c \u30de\u30a6\u30b9\u306e T \u7d30\u80de\u306f\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u523a\u6fc0\u306b\u5fdc\u7b54\u3057\u3066\u7523\u751f\u3059\u308b GM-CSF \u307e\u305f\u306f IL-17A \u306e\u91cf\u304c\u6e1b\u5c11\u3057\u3001IL-17A \u304a\u3088\u3073 GM-CSF \u7523\u751f T \u7d30\u80de\u306e\u5897\u6b96\u306e\u60aa\u5faa\u74b0\u306f\u751f\u3058\u307e\u305b\u3093\u3002\u60aa\u5316\u3057\u305f\u3002 (\u00a0B<\/strong>\u00a0) \u30b6\u30a4\u30e2\u30b5\u30f3\u51e6\u7406\u3057\u305f SKG \u30de\u30a6\u30b9\u306e T \u7d30\u80de\u306f\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u7523\u751f\u3092\u523a\u6fc0\u3059\u308b GM-CSF \u3092\u512a\u5148\u7684\u306b\u7523\u751f\u3057\u3001\u305d\u306e\u7d50\u679c\u3001IL-17A \u304a\u3088\u3073 GM-CSF \u7523\u751f T \u7d30\u80de\u5897\u6b96\u306e\u60aa\u5faa\u74b0\u304c\u60aa\u5316\u3057\u307e\u3057\u305f\u3002 (\u00a0C<\/strong>\u00a0\u2013\u00a0E<\/strong>\u00a0) \u30b6\u30a4\u30e2\u30b5\u30f3\u51e6\u7406 SKG \u30de\u30a6\u30b9\u306b\u304a\u3051\u308b IL-17A \u4e2d\u548c (C)\u3001GM-CSF \u4e2d\u548c (D)\u3001\u304a\u3088\u3073\u6297 IL-6R Ab (E) \u51e6\u7406\u306e\u30e2\u30c7\u30eb\u3002\u200b14\u200b<\/sup><\/span><\/p>\n\n\n\n

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    15.<\/div>
    Kwon OC, Lee EJ, Chang EJ, et al. IL-17A+GM-CSF+ Neutrophils Are the Major Infiltrating Cells in Interstitial Lung Disease in an Autoimmune Arthritis Model. Front Immunol<\/i>. Published online July 2, 2018. doi:10.3389\/fimmu.2018.01544<\/a><\/div>\n <\/div>\n<\/li><\/ol><\/section>\n","protected":false},"excerpt":{"rendered":"

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