{"id":250,"date":"2017-09-23T12:30:33","date_gmt":"2017-09-23T03:30:33","guid":{"rendered":"https:\/\/plaza.umin.ac.jp\/~OIO\/?p=250"},"modified":"2019-02-03T17:43:48","modified_gmt":"2019-02-03T08:43:48","slug":"self-controlled-case-series-sccs","status":"publish","type":"post","link":"https:\/\/plaza.umin.ac.jp\/~OIO\/?p=250","title":{"rendered":"self-controlled case series (SCCS)"},"content":{"rendered":"

\u306f\u3058\u3081\u306b<\/h2>\n

\u3053\u3053\u306e\u6240\u6ce8\u529b\u3057\u3066\u304d\u305f\u4ed5\u4e8b\u304c\u4e00\u6bb5\u843d\u3057\u3066\u3001\u3053\u306e\u9031\u672b\u306f\u826f\u3044\u5177\u5408\u306b\u4e00\u606f\u3064\u3051\u307e\u3059\u3002<\/p>\n

\u3055\u304b\u306e\u307c\u308b\u3053\u3068\u6570\u304b\u6708\u3001\u4eca\u5f8c\u4f7f\u3046\u304b\u3082\u3057\u308c\u306a\u3044\u3001\u81ea\u5206\u306b\u3068\u3063\u3066\u65b0\u3057\u3044\u624b\u6cd5\u3092\u8a66\u3057\u3066\u304a\u3053\u3046\u3068\u3001 Sequence Symmetry Analysis (SSA)\u3092\u3084\u3063\u3066\u307f\u305f\u3093\u3060\u3051\u3069\u3001\u3053\u308c\u304c\u30a4\u30de\u30a4\u30c1\u3002\u4f55\u304c\u30a4\u30de\u30a4\u30c1\u3063\u3066\u3001\u88fd\u85ac\u5de5\u696d\u5354\u4f1a\u306e\u30db\u30fc\u30e0\u30da\u30fc\u30b8\u306bSAS\u306e\u30d7\u30ed\u30b0\u30e9\u30e0\u304c\u516c\u958b<\/a>\u3055\u308c\u3066\u3044\u3066\u3001\u305d\u308c\u3092\u898b\u306a\u304c\u3089\u3084\u3063\u3066\u3044\u308b\u3093\u3060\u3051\u3069\u7d30\u304b\u3044\u6570\u5b57\u304c\u5408\u308f\u306a\u3044\u3002\u7d50\u679c\u306f\u3060\u3044\u305f\u3044\u8fd1\u3044\u3068\u3053\u308d\u307e\u3067\u306f\u884c\u304f\u3093\u3060\u3051\u3069\u3001\u4f55\u304b\u7e54\u308a\u8fbc\u3080\u3079\u304d\u30a2\u30a4\u30c7\u30a3\u30a2\u304c\u8db3\u308a\u306a\u3044\u306e\u304b\u3002\u3061\u306a\u307f\u306b\u3001\u4f5c\u6210\u306b\u304b\u304b\u308f\u3063\u305f\u30bf\u30b9\u30af\u30d5\u30a9\u30fc\u30b9\u306e\u65b9\u3005\u306e\u540d\u8a89\u306e\u305f\u3081\u306b\u3082\u3046\u5c11\u3057\u66f8\u3044\u3066\u304a\u304d\u307e\u3059\u3068\u3001\u3053\u306e\u516c\u958b\u3055\u308c\u3066\u3044\u308b\u30d7\u30ed\u30b0\u30e9\u30e0\u304c\u304a\u304b\u3057\u3044\u3068\u3044\u3046\u306e\u3067\u306f\u306a\u304f\u3001\u307e\u305a\u3001\u4ed6\u4eba\u306e\u66f8\u3044\u305f\u30d7\u30ed\u30b0\u30e9\u30e0\u304b\u3089\u3001\u4f55\u304c\u306a\u3055\u308c\u3066\u3044\u308b\u306e\u304b\u3068\u3044\u3046\u306e\u3092\u8aad\u307f\u89e3\u304f\u306e\u306f\u3068\u3066\u3082\u96e3\u3057\u3044\u4f5c\u696d\u3067\u3001\u3053\u306e\u30d7\u30ed\u30b0\u30e9\u30e0\u3092\u53c2\u8003\u306b\u3057\u3066\u3001\u4f55\u304c\u3055\u308c\u3066\u3044\u308b\u306e\u304b\u3092\u8aad\u307f\u53d6\u3063\u3066\u3001\u305d\u306e\u3046\u3048\u3067\u81ea\u5206\u306b\u3068\u3063\u3066\u308f\u304b\u308a\u3084\u3059\u3044\u3088\u3046\u306b\u66f8\u304d\u63db\u3048\u308b\u306e\u3067\u3001\u304a\u304b\u3057\u306a\u3053\u3068\u304c\u8d77\u304d\u3066\u3044\u308b\u306e\u3067\u3059\u3002\u304a\u305d\u3089\u304fNull effect sequence ratio, NSR\u306e\u8a08\u7b97\u306e\u3068\u3053\u308d\u304c\u30ad\u30e2\u306a\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u601d\u3044\u3064\u3064\u3001\u3057\u3070\u3089\u304f\u3053\u3061\u3089\u306f\u653e\u7f6e\u3057\u3066\u982d\u3092\u51b7\u3084\u3059\u3053\u3068\u306b\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u3002<\/p>\n

Self-controlled case series (SCCS\uff09<\/h2>\n

SCCS\u3068\u306f\uff1f<\/h3>\n

\u540c\u3058self-controlled\u30c7\u30b6\u30a4\u30f3\u306eSCCS\u3092\u8a66\u3057\u3066\u307f\u307e\u3059\u3002\u539f\u7406\u306f\u3053\u306e\u30b9\u30e9\u30a4\u30c9<\/a>2\u30da\u30fc\u30b8\u76ee\u3002\u5f53\u6642PMDA\u3067\u6771\u5927epistat\u306e\u7af9\u5185 \u7531\u5247\u3055\u3093\u304c\u5b66\u4f1a\u767a\u8868\u3057\u305f\u30b9\u30e9\u30a4\u30c9\u304b\u3089\u3067\u3059\u3002<\/p>\n

\"\"<\/a><\/p>\n

 <\/p>\n

\u30c7\u30fc\u30bf<\/h3>\n

\u30c7\u30fc\u30bf\u304c\u516c\u958b\u3055\u308c\u3066\u3044\u308b\u306e\u3067\u3001\u624b\u6cd5\u3092\u8a66\u3059\u306e\u306b\u3061\u3087\u3046\u3069\u3088\u3044\u3068\u3044\u3046\u3053\u3068\u3067\u3001\u8a66\u3057\u3066\u307f\u308b\u306e\u306f\u3001\u3053\u306e\u6587\u732eWhitaker HJ, Farrington CP and Musonda P. Tutorial in Biostatistics: The self-controlled case series method. Statistics in Medicine 2006, 25(10): 1768-1797.<\/a>\u306b\u51fa\u3066\u304f\u308bMMR\u30ef\u30af\u30c1\u30f3\u5f8c\u306e\u9ac4\u819c\u708e\u3002Table 2\u306bOxford data\u3068\u3057\u3066\u63d0\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<\/colgroup>\n\n\n\n\n\n\n\n\n\n\n\n\n
indiv<\/td>\neventday<\/td>\nstart<\/td>\nend<\/td>\nexday<\/td>\n<\/tr>\n
1<\/td>\n398<\/td>\n365<\/td>\n730<\/td>\n458<\/td>\n<\/tr>\n
2<\/td>\n413<\/td>\n365<\/td>\n730<\/td>\n392<\/td>\n<\/tr>\n
3<\/td>\n449<\/td>\n365<\/td>\n730<\/td>\n429<\/td>\n<\/tr>\n
4<\/td>\n455<\/td>\n365<\/td>\n730<\/td>\n433<\/td>\n<\/tr>\n
5<\/td>\n472<\/td>\n365<\/td>\n730<\/td>\n432<\/td>\n<\/tr>\n
6<\/td>\n474<\/td>\n365<\/td>\n730<\/td>\n395<\/td>\n<\/tr>\n
7<\/td>\n485<\/td>\n365<\/td>\n730<\/td>\n470<\/td>\n<\/tr>\n
8<\/td>\n524<\/td>\n365<\/td>\n730<\/td>\n496<\/td>\n<\/tr>\n
9<\/td>\n700<\/td>\n365<\/td>\n730<\/td>\n428<\/td>\n<\/tr>\n
10<\/td>\n399<\/td>\n365<\/td>\n730<\/td>\n716<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u30c7\u30fc\u30bf\u306f10\u4f8b\u3067\u3059\u3079\u3066\u3002\u89b3\u5bdf\u3057\u305f\u306e\u306f\u3001\u5168\u54e1\u751f\u5f8c366\u65e5\u304b\u3089730\u65e5\u3002\u30c7\u30fc\u30bf\u306e\u30ab\u30e9\u30e0start, end\u306f\u89b3\u5bdf\u671f\u9593\u306e\u958b\u59cb\u3092\u751f\u5f8c\u306e\u65e5\u6570\u3067\u793a\u3057\u3066\u3044\u307e\u3059\u3002 exday\u304c\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306e\u65e5\u3001eventday\u304c\u9ac4\u819c\u708e\u3068\u8a3a\u65ad\u3055\u308c\u305f\u65e5\u3001\u3067\u3001\u3053\u308c\u3082\u751f\u5f8c\u306e\u65e5\u6570\u3067\u793a\u3057\u3066\u3044\u307e\u3059\u3002
\n\u5143\u8ad6\u6587\u3067\u306f\u3001at risk \u671f\u9593\u3092mumps virus\u306ereplication\u306b\u304b\u304b\u308b\u671f\u9593\u306b\u57fa\u3065\u3044\u3066\u3001shot\u304b\u308915 – 35\u65e5\u5f8c\u3068\u8a2d\u5b9a\u3057\u307e\u3057\u305f\u3002\uff08\u5143\u6587\u732e\u306eTable 2\u3067\u306f\u3001\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u65e5\u306f\u300cpre-risk\u304b\u308914\u3092\u5f15\u3044\u305f\u65e5\u300d\u306b\u306a\u308a\u307e\u3059\u3002\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u304b\u308914\u65e5\u76ee\u307e\u3067\u304cpre-risk, 15\u65e5\u76ee\u304b\u3089\u304cat-risk\u3068\u3044\u3046\u8003\u3048\u65b9\u3060\u3068\u601d\u3044\u307e\u3059\uff09\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3057\u305f\u30c7\u30fc\u30bf\u306b\u306f\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u65e5\u304cexday\u3068\u3057\u3066\u5165\u529b\u3055\u308c\u3066\u3044\u307e\u3059\u306e\u3067\u6b21\u306e\u3088\u3046\u306bpre-risk(ex1), risk end (ex2)\u3092\u8a08\u7b97\u3057\u307e\u3059\u3002\u8a2d\u5b9a\u3057\u305fat risk\u306e\u671f\u9593\u306b\u3088\u3063\u3066\u306f\u30b9\u30af\u30ea\u30d7\u30c8\u3092\u89e6\u308b\u3079\u304d\u500b\u6240\u304c\u30b3\u30b3\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/strong><\/p>\n

ex1 <- dat$exday + 14
\nex2 <- dat$exday + 35<\/p>\n

\u89b3\u5bdf\u671f\u9593\u4e2d\u306e\u3059\u3079\u3066\u306e\u65e5\u3092\u3001at risk\u306e\u671f\u9593\u304b\u3069\u3046\u304b\u6b63\u78ba\u306b\u5206\u985e\u3057\u305f\u3044\u306e\u3067\u3001\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u304c331 – 715\u65e5\u306e\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u6b74\u3092\u8981\u6c42\u3057\u305f\uff08\u539f\u6587\uff09\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002case #10\u306f\u3001716\u65e5\u306b\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u6f5c\u4f0f\u671f\u9593\u304c\u89b3\u5bdf\u671f\u9593\u7d42\u4e86\u5f8c\u307e\u3067\u7d99\u7d9a\u3057\u307e\u3059\u306e\u3067\u3001\u7d50\u679c\u3068\u3057\u3066\u89b3\u5bdf\u671f\u9593\u4e2d\u306bat risk\u306e\u671f\u9593\u304c\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n

\u30c7\u30fc\u30bf\u3092\u30b0\u30e9\u30d5\u30a3\u30ab\u30eb\u306b\u63d0\u793a\u3057\u3066\u3044\u308b\u56f3\u304c\u3042\u3063\u305f\u306e\u3067\u3001\u5f15\u7528\u3002\u7070\u8272\u306e\u671f\u9593\u304cat risk\u306e\u671f\u9593\u3002\u305d\u3057\u3066\u3001547\u3067\u7dda\u304c\u5f15\u3044\u3066\u3042\u308b\u306e\u306f\u3001\u3053\u3053\u3067\u5e74\u9f62\u5c64\u3092\u5206\u3051\u3066\u8abf\u6574\u56e0\u5b50\u3068\u3057\u3066\u4f7f\u7528\u3057\u3066\u3044\u308b\u306e\u3067\u3001\u305d\u308c\u3092\u793a\u3059\u3064\u3082\u308a\u3067\u7dda\u3092\u5165\u308c\u305f\u306e\u3067\u3057\u3087\u3046\u3002\uff08\u4f8b\u793a\u3068\u3057\u3066\u793a\u3057\u305f\u56f3\u306e\u4e2d\u306b\u306f\u3001\u5e74\u9f62\u5c64\u3092\u307e\u305f\u3050\u30ea\u30b9\u30af\u671f\u9593\u3092\u6709\u3057\u3066\u3044\u308b\u75c7\u4f8b\u304c\u51fa\u3066\u3053\u306a\u304b\u3063\u305f\u306e\u3067\u3001\u4f55\u3092\u8aac\u660e\u3057\u305f\u304f\u3066547\u65e5\u3067\u7dda\u3092\u5165\u308c\u305f\u306e\u304b\u308f\u304b\u308a\u306b\u304f\u304f\u306a\u3063\u3066\u3044\u307e\u3059\u304c\u3002\uff09366 – 547 \u3092\uff11\u5c64\u3001548 – 730\u3092\uff12\u5c64\u306b\u3057\u3066\u3044\u307e\u3059\u3002\u89b3\u5bdf\u671f\u9593\u4e2d\u306b\u30a4\u30d9\u30f3\u30c8\u304c\u767a\u751f\u3057\u305f\u3089\u3001\u305d\u308c\u4ee5\u964d\u306f\u89b3\u5bdf\u671f\u9593\u306b\u3057\u306a\u3044\u3068\u3044\u3046\u3088\u3046\u306a\u64cd\u4f5c\u3092\u901a\u5e38\u884c\u3044\u307e\u3059\u304c\u3001\u3053\u306e\u96c6\u8a08\u3067\u306f\u3001\u305d\u3046\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u5168\u4f53\u306e\u89b3\u5bdf\u671f\u9593\u3092\u96c6\u8a08\u3057\u3066\u3001\u30a4\u30d9\u30f3\u30c8\u304c\u3069\u306e\u671f\u9593\u306b\u767a\u751f\u3057\u305f\u304b\u3068\u3044\u3046\u3088\u3046\u306a\u601d\u60f3\u3067\u96c6\u8a08\u3059\u308b\u3088\u3046\u3067\u3059\u3002<\/p>\n

\u5e74\u9f62\u5c64\u3092\u30d7\u30ed\u30b0\u30e9\u30e0\u3057\u3066\u3044\u308b\u306e\u306f\u3053\u3053\u3067\u3059\u3002<\/p>\n

age <- c(547)<\/h2>\n

#age groups
\nagegr <- cut(cutp, breaks = c(min(dat$start), age, max(dat$end)), labels = FALSE)
\nagegr <- as.factor(agegr)<\/p>\n

 <\/p>\n

\"\"<\/a><\/p>\n

 <\/p>\n

\u8ad6\u6587\u306e\u7d50\u679c<\/h3>\n

\u8ad6\u6587\u306e\u7d50\u679c\u304c\u6b21\u306e\u901a\u308a\u3067\u3001<\/p>\n

\"\"<\/a><\/p>\n

\u81ea\u5206\u3067\u3082\u8a08\u7b97<\/h3>\n

\u81ea\u5206\u3067\u5b9f\u884c\u3057\u305f\u7d50\u679c\u304c\u6b21\u3002\u3081\u3067\u305f\u304f\u3001\u7d50\u679c\u304c\u4e00\u81f4\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u3081\u3067\u305f\u3057\u3081\u3067\u305f\u3057\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u304a\u308f\u308a\u306b<\/h3>\n

\u5b9f\u884c\u3057\u305fR\u306e\u30b9\u30af\u30ea\u30d7\u30c8\u304c\u3053\u3061\u3089<\/a>\u3002\u5b9f\u884c\u306b\u5f53\u305f\u3063\u3066\u306f\u79c1\u306e\u74b0\u5883\u306b\u5408\u3046\u3088\u3046\u306bOpen University\u306e\u30db\u30fc\u30e0\u30da\u30fc\u30b8\u306e\u30b9\u30af\u30ea\u30d7\u30c8\u3092\u4e00\u90e8\u6539\u7de8\u3057\u307e\u3057\u305f\u3002\u5b9f\u884c\u7d50\u679c\u304c\u8ad6\u6587\u3067\u63d0\u793a\u3055\u308c\u3066\u3044\u305f\u3082\u306e\u3068\u4e00\u81f4\u3059\u308b\u306e\u3067\u3001\u60aa\u304f\u306f\u306a\u3044\u3060\u308d\u3046\u3068\u601d\u3044\u307e\u3059\u3002\u3053\u308c\u3067\u307e\u305f\u3001\u65b0\u305f\u306a\u624b\u6cd5\u3092\u7528\u3044\u305f\u3044\u308d\u3044\u308d\u306a\u8a55\u4fa1\u304c\u3067\u304d\u308b\u9053\u7b4b\u304c\u4ed8\u304d\u307e\u3057\u305f\u3002\uff08\u3064\u3065\u304f<\/a>\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"

\u306f\u3058\u3081\u306b \u3053\u3053\u306e\u6240\u6ce8\u529b\u3057\u3066\u304d\u305f\u4ed5\u4e8b\u304c\u4e00\u6bb5\u843d\u3057\u3066\u3001\u3053\u306e\u9031\u672b\u306f\u826f\u3044\u5177\u5408\u306b\u4e00\u606f\u3064\u3051\u307e\u3059\u3002 \u3055\u304b\u306e\u307c\u308b\u3053\u3068\u6570\u304b\u6708\u3001\u4eca\u5f8c\u4f7f\u3046\u304b\u3082\u3057\u308c\u306a\u3044\u3001\u81ea\u5206\u306b\u3068\u3063\u3066\u65b0\u3057\u3044\u624b\u6cd5\u3092\u8a66\u3057\u3066\u304a\u3053\u3046\u3068\u3001 Sequence Symmetry Analysi…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":true,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[4],"tags":[],"class_list":["post-250","post","type-post","status-publish","format-standard","hentry","category-science"],"jetpack_featured_media_url":"","jetpack_shortlink":"https:\/\/wp.me\/p9b6zl-42","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/posts\/250","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=250"}],"version-history":[{"count":0,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/posts\/250\/revisions"}],"wp:attachment":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=250"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=250"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=250"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}