{"id":2489,"date":"2020-09-20T11:22:05","date_gmt":"2020-09-20T02:22:05","guid":{"rendered":"https:\/\/plaza.umin.ac.jp\/~OIO\/?p=2489"},"modified":"2020-09-20T11:33:06","modified_gmt":"2020-09-20T02:33:06","slug":"cbioportal-%e3%82%92%e4%bd%bf%e3%81%a3%e3%81%a6%e3%81%bf%e3%81%9f%e3%80%9c%e9%81%ba%e4%bc%9d%e5%ad%90%e5%a4%89%e7%95%b0%e3%82%92%e8%a1%a8%e7%a4%ba%e3%81%97%e3%81%a6%e3%81%bf%e3%81%9f","status":"publish","type":"post","link":"https:\/\/plaza.umin.ac.jp\/~OIO\/?p=2489","title":{"rendered":"cBioPortal \u3092\u4f7f\u3063\u3066\u307f\u305f\u301c\u907a\u4f1d\u5b50\u5909\u7570\u3092\u8868\u793a\u3057\u3066\u307f\u305f"},"content":{"rendered":"

cBioPortal\u3068\u306f\u4f55\u304b<\/h1>\n

cBioPortal for Cancer Genomics\u3068\u306f\u4f55\u304b\u3001\u3068\u3044\u3046\u554f\u3044\u306b\u3064\u3044\u3066\u306f\u30aa\u30ea\u30b8\u30ca\u30eb\u306e\u30b5\u30a4\u30c8<\/a>\u3092\u307f\u3066\u3044\u305f\u3060\u304f\u306e\u304c\u901f\u3044\u306e\u3067\u3057\u3087\u3046\u3002\u516c\u958b\u3055\u308c\u305f\u907a\u4f1d\u5b50\u95a2\u9023\u60c5\u5831\uff08\u5909\u7570\u60c5\u5831\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u60c5\u5831\u3001\u81e8\u5e8a\u60c5\u5831\u4ed6\uff09\u3068\u89e3\u6790\u30c4\u30fc\u30eb\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u3082\u306e\u3001\u3068\u3044\u3046\u306e\u304c\u79c1\u306e\u7406\u89e3\u3067\u3059\u3002\u3053\u308c\u3092\u4f7f\u3063\u3066\u4f55\u304c\u5224\u308b\u306e\u304b\u3001\u3068\u3044\u3046\u3053\u3068\u3092\u5c11\u3057\u89e6\u3063\u3066\u307f\u307e\u3057\u305f\u306e\u3067\u3001\u30e1\u30e2\u3057\u3066\u3086\u304d\u307e\u3059\u3002<\/p>\n

\u4eca\u56de\u306f\u307e\u305a\u7b2c\u4e00\u5f3e\u3068\u3057\u3066\u907a\u4f1d\u5b50\u5909\u7570\u306b\u304b\u304b\u308b\u60c5\u5831\u3092\u8868\u793a\u3057\u3066\u307f\u307e\u3057\u305f\u3002<\/p>\n

\u30c7\u30fc\u30bf\u30bb\u30c3\u30c8\u306e\u9078\u629e<\/h2>\n

cBioPortal\u3067\u306f\u89e3\u6790\u3057\u3084\u3059\u3044\u5f62\u3067\u683c\u7d0d\u3055\u308c\u305f\u30c7\u30fc\u30bf\u304c\u63d0\u4f9b\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4eca\u56de\u306f\u3068\u308a\u3042\u3048\u305a\u3053\u306e\u63d0\u4f9b\u3055\u308c\u305f\u30c7\u30fc\u30bf\u3092\u8868\u793a\u3059\u308b\u3053\u3068\u306b\u3057\u307e\u3059\u3002\u6b21\u306e\u56f3\u306fcBioPortal\u306e\u30c8\u30c3\u30d7\u30da\u30fc\u30b8<\/a>\u3067\u3059\u3002<\/p>\n

\"\"<\/p>\n

    \n
  1. Pan Cancer\u306e\u306a\u304b\u306e\u3001MSK-IMPACT clinical sequencing cohort\u306e\u30d5\u30a1\u30a4\u30eb\u306e\u30c1\u30a7\u30c3\u30af\u30dc\u30c3\u30af\u30b9\u3092\u30af\u30ea\u30c3\u30af\u3057\u3066\u9078\u629e\u3057\u307e\u3059\u3002<\/li>\n
  2. \u00a0\u4e0b\u306e\u307b\u3046\u306b\u3042\u308b\u300cQuery By Gene\u300d\u30dc\u30bf\u30f3\u3092\u30af\u30ea\u30c3\u30af\u3057\u307e\u3059\u3002<\/li>\n<\/ol>\n

    \u8868\u793a\u3059\u308b\u907a\u4f1d\u5b50\u306e\u9078\u629e<\/h2>\n

    \u4e0a\u8a18\u3067\u30dc\u30bf\u30f3\u3092\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u63a8\u79fb\u3059\u308b\u753b\u9762\u304c\u6b21\u3067\u3059\u3002<\/p>\n

    \"\"<\/p>\n

      \n
    1. Enter Genes: \u306e\u30dc\u30c3\u30af\u30b9\u5185\u306b\u907a\u4f1d\u5b50\u540d(HUGO gene nomenclature\uff09\u3067\u5165\u529b\u3057\u307e\u3059\u3002\u4eca\u56de\u306fERBB2\u3068\u5165\u529b\u3057\u3066\u3044\u307e\u3059\u3002\u500b\u4eba\u7684\u306b\u306fHER2 (erb-b2 receptor tyrosine kinase 2)\u3068\u3044\u3046\u540d\u524d\u3067\u3001Gefitinib\u306e\u6a19\u7684\u3068\u3057\u3066\u89aa\u3057\u3093\u3067\u304d\u305f\u907a\u4f1d\u5b50\u3067\u3059\u304c\u3001HUGO gene nomenclature\u3067\u306fERBB2\u3068\u3044\u3046\u30b7\u30f3\u30dc\u30eb\u3067\u3059\u3002<\/li>\n
    2. \u300cSubmit Query\u300d\u00a0 \u30dc\u30bf\u30f3\u3092\u30af\u30ea\u30c3\u30af\u3057\u307e\u3059\u3002<\/li>\n<\/ol>\n

      \u307e\u305a\u306f\u6982\u8981\u304c\u8868\u793a\u3055\u308c\u307e\u3059<\/h2>\n

      \u4e0a\u8a18\u3067\u30af\u30ea\u30c3\u30af\u3057\u3066\u3057\u3070\u3089\u304f\u3059\u308b\u3068\u8868\u793a\u3055\u308c\u308b\u753b\u9762\u304c\u6b21\u306e\u901a\u308a\u3067\u3059\u3002<\/p>\n

      \"\"<\/p>\n

      \u3053\u306e\u753b\u9762\u306fOnco Print\u3068\u3044\u3046\u30bf\u30d6\u306e\u60c5\u5831\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u8d64\u304f\u3066\u592a\u3044\u30e9\u30a4\u30f3\u304c\u76ee\u306b\u5165\u308a\u307e\u3059\u3002\u4e0b\u306e\u30ec\u30b8\u30a7\u30f3\u30c9\u3092\u307f\u307e\u3059\u3068\u3001\u3053\u308c\u306fgene amplification\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u56f3\u3082\u3088\u304f\u898b\u308b\u3068\u3044\u308d\u3044\u308d\u306a\u60c5\u5831\u304c\u3042\u308a\u307e\u3059\u3002\u89e3\u6790\u5bfe\u8c61\u306e\u75c7\u4f8b\u306e7\uff05\u306e\u75c7\u4f8b\u306b\u4f55\u3089\u304b\u306e\u5909\u7570\u304c\u3042\u308b\u3001\u3042\u308b\u3044\u306f\u3001\u89e3\u6790\u5bfe\u8c61\u306e\u30b5\u30f3\u30d7\u30eb\u306e7\uff05\u306e\u30b5\u30f3\u30d7\u30eb\u306b\u4f55\u3089\u304b\u306e\u7570\u5e38\u304c\u3042\u308b\u3053\u3068\u3001\u30c9\u30e9\u30a4\u30d0\u30fc\u5909\u7570\u3082\u3042\u308c\u3070\u3001\u610f\u7fa9\u304c\u4e0d\u660e\u306e\u5909\u7570\u3082\u3042\u308b\u3053\u3068\u3082\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u70b9\u5909\u7570\u306e\u69d8\u306a\u3082\u306e\u3082\u3042\u308c\u3070\u4ed6\u306e\u907a\u4f1d\u5b50\u3078\u306e\u878d\u5408\u3084\u9014\u4e2d\u3067\u7ffb\u8a33\u304c\u7d42\u308f\u308btruncation\u306b\u306a\u308b\u5909\u7570\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n

      \u304c\u3093\u7a2e\u3054\u3068\u306e\u60c5\u5831\u3092\u898b\u308b\u306b\u306f<\/h2>\n
        \n
      1. \u300cCancer Types Summary\u300d\u30bf\u30d6\u3092\u30af\u30ea\u30c3\u30af\u3057\u3066\u3001\u304c\u3093\u7a2e\u3054\u3068\u306e\u5909\u7570\u60c5\u5831\u3092\u8868\u793a\u3057\u307e\u3059<\/li>\n<\/ol>\n

        \"\"<\/p>\n

        \u5909\u7570\u306e\u983b\u5ea6\u304c\u6bd4\u8f03\u7684\u591a\u3044\u306e\u304c\u98df\u9053\u764c\u3067\u3001Amplification\u306e\u983b\u5ea6\u304c\u591a\u3044\u69d8\u3067\u3059\u3002<\/p>\n

        \u907a\u4f1d\u5b50\u306e\u3069\u3053\u306b\u5909\u7570\u304c\u591a\u3044\u304b<\/h2>\n

        \u300cMutation\u300d\u30bf\u30d6\u3092\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u6b21\u306e\u753b\u9762\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n

        \"\"<\/p>\n

        \u3053\u306e\u753b\u9762\u3067\u306f\u3001\u907a\u4f1d\u5b50\u306e\u4e2d\u306e\u3069\u3053\u306b\u5909\u7570\u304c\u3042\u308b\u306e\u304b\u3001\u3042\u308b\u5834\u5408\u306f\u983b\u5ea6\u3082\u898b\u3066\u53d6\u308c\u307e\u3059\u3002\u307e\u305f\u3001\u907a\u4f1d\u5b50\u306e\u5404\u30c9\u30e1\u30a4\u30f3\u304c\u8868\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u56f3\u306e\u4e2d\u3067\u98db\u3073\u51fa\u3057\u3066\u76ee\u7acb\u3063\u3066\u3044\u308b\u3001S310F\/Y\u306f310 \u756a\u76ee\u306e\u30bb\u30ea\u30f3\u304c\u30d5\u30a7\u30cb\u30eb\u30a2\u30e9\u30cb\u30f3\u3084\u30bf\u30a4\u30ed\u30b7\u30f3\u306b\u5909\u308f\u308b\u5909\u7570\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u5909\u7570\u304c\u3042\u308b\u5834\u6240\u304c\u7ffb\u8a33\u5f8c\u306e\u86cb\u767d\u8cea\u3068\u3057\u3066\u306fFurin-like\u30c9\u30e1\u30a4\u30f3\u306b\u5b58\u5728\u3059\u308b\u3053\u3068\u3082\u308f\u304b\u308a\u307e\u3059\u3002\u305d\u3057\u3066\u3001\u9ad8\u3044\u4f4d\u7f6e\u306b\u4e38\u304c\u3042\u308b\u306e\u306f\u305d\u306e\u5909\u7570\u306e\u983b\u5ea6\u304c\u591a\u3044\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u7dd1\u306e\u4e38\u3092\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u3001\u4e0b\u306e\u75c7\u4f8b\u30ea\u30b9\u30c8\u3082\u5909\u5316\u3057\u307e\u3059\u3002<\/p>\n

        \u4e0a\u56f3\u306e\u72b6\u614b\u3067\u3001\u53f3\u4e2d\u7a0b\u306b\u3042\u308a\u307e\u3059\u866b\u30e1\u30ac\u30cd\u306e\u30a2\u30a4\u30b3\u30f3\u306e\u30dc\u30c3\u30af\u30b9\u306b\u300clung\u300d\u3068\u5165\u529b\u3057\u3066\u307f\u307e\u3059\u3068\u3001\u80ba\u304c\u3093\u306e\u60c5\u5831\u306b\u66f8\u304d\u63db\u3048\u3089\u308c\u307e\u3059\u3002\uff08\u4ed6\u306e\u304c\u3093\u7a2e\u306e\u60c5\u5831\u3092\u9664\u3044\u305f\u5f62\u3067\u8868\u793a\u3055\u308c\u307e\u3059\u3002\uff09<\/p>\n

        \"\"<\/p>\n

        \u5168\u304c\u3093\u7a2e\u306e\u60c5\u5831\u3067\u306f\u5909\u7570\u306e\u983b\u5ea6\u304c\u9ad8\u304b\u3063\u305f310\u756a\u76ee\u306e\u30a2\u30df\u30ce\u9178\u6b8b\u57fa\u306e\u5909\u7570\u306f\u76ee\u7acb\u305f\u306a\u304f\u306a\u308a\u307e\u3057\u3066\u3001\u4ee3\u308f\u308a\u306bY772_A775 dup\u3068\u3044\u3046\u5909\u7570\u306e\u983b\u5ea6\u304c\u76ee\u7acb\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u5909\u7570\u304c\u3042\u308b\u306e\u306f\u30bf\u30a4\u30ed\u30b7\u30f3\u30ea\u30f3\u9178\u5316\u9175\u7d20\u30c9\u30e1\u30a4\u30f3\u3068\u547c\u3070\u308c\u308b\u90e8\u5206\u306b\u306a\u308a\u307e\u3059\u3002\u3053\u306e\u5909\u7570\u3092\u30af\u30ea\u30c3\u30af\u3057\u3066\u7f6e\u3044\u3066\u3001\u4e0b\u306e\u75c7\u4f8b\u30ea\u30b9\u30c8\u306e\u30a2\u30ce\u30c6\u30fc\u30b7\u30e7\u30f3\u306e\u30a2\u30a4\u30b3\u30f3\u306b\u30de\u30a6\u30b9\u3092\u30aa\u30fc\u30d0\u30fc\u3059\u308b\uff08\u30af\u30ea\u30c3\u30af\u306f\u3057\u306a\u3044\uff09\u3068\u3001\u3053\u306e\u5909\u7570\u304chot spot\u306b\u3042\u308b\u4e8b\u3084\u3001oncogenic\u306e\u5909\u7570\u3067\u3042\u308b\u3053\u3068\u304c\u8868\u793a\u3055\u308c\u307e\u3059\u3002<\/p>\n

        \u866b\u30e1\u30ac\u30cd\u30a2\u30a4\u30b3\u30f3\u306bBreast\u3068\u5165\u308c\u3066\u898b\u308b\u3068\u4eca\u5ea6\u306f\u4e73\u304c\u3093\u3067\u306e\u60c5\u5831\u304c\u8868\u793a\u3055\u308c\u307e\u3059\u3002\u82e5\u5e72\u898b\u305f\u76ee\u306f\u4ee3\u308f\u308a\u307e\u3059\u304c\u3001\u4e73\u304c\u3093\u3082\u80ba\u304c\u3093\u540c\u69d8\u306b\u3001\u30bf\u30a4\u30ed\u30b7\u30f3\u30ea\u30f3\u9178\u5316\u9175\u7d20\u30c9\u30e1\u30a4\u30f3\u3067\u306e\u5909\u7570\u304c\u591a\u3044\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3059\u3002\u4e00\u65b9\u3001bladder\u3068\u5165\u529b\u3057\u307e\u3059\u3068\u3001\u7d30\u80de\u5916\u30c9\u30e1\u30a4\u30f3\u306e\u5909\u7570\u304c\u591a\u304f\u3001\u7d30\u80de\u5185\u306e\u30bf\u30a4\u30ed\u30b7\u30f3\u30ea\u30f3\u9178\u5316\u9175\u7d20\u30c9\u30e1\u30a4\u30f3\u306e\u5909\u7570\u304c\u76f8\u5bfe\u7684\u306b\u5c11\u306a\u3044\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3059\u3002<\/p>\n

        \u4eca\u5ea6\u306f\u53f3\u5074\u306e\u300cview 3D structure\u300d\u30dc\u30bf\u30f3\u3092\u62bc\u3057\u3066\u307f\u307e\u3059\u3002<\/p>\n

        \"\"<\/p>\n

        PDB chains \u306e\u3042\u305f\u308a\u306b\u30de\u30a6\u30b9\u3092\u6301\u3063\u3066\u304f\u308b\u3068\u3001PDB\u306e\u3069\u306e\u7acb\u4f53\u69cb\u9020\u60c5\u5831\u3067\u8868\u793a\u3059\u308b\u304b\u3092\u9078\u3076\u3053\u3068\u304c\u3067\u304d\u308b\u69d8\u306b\u306a\u308a\u307e\u3059\u3002\u4e0a\u56f3\u306f\u4e00\u756a\u4e0a\u306e\u884c\u306e\u53f3\u5074\uff08C\u672b\u7aef\u5074\uff09\u306e\u56db\u89d2\u3092\u30af\u30ea\u30c3\u30af\u3057\u305f\u72b6\u614b\u3067\u3059\u3002\u53f3\u5074\u306e\u7a93\u306b\u7acb\u4f53\u69cb\u9020\u304c\u8868\u793a\u3055\u308c\u307e\u3057\u3066\u3001\u3053\u308c\u3092\u304f\u308a\u304f\u308a\u56de\u3057\u305f\u308a\u62e1\u5927\u7e2e\u5c0f\u3057\u3066\u8868\u793a\u3057\u305f\u308a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u30b0\u30ec\u30fc\u306e\u4e2d\u306b\u7dd1\u3084\u30a8\u30f3\u30b8\u306e\u7740\u8272\u304c\u306a\u3055\u308c\u3066\u3044\u308b\u5834\u6240\u306f\u5909\u7570\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u5834\u6240\u3092\u793a\u3057\u307e\u3059\u3002<\/p>\n

        \u4ed6\u306b\u3082\u3001\u6a5f\u80fd\u304c\u3064\u3044\u3066\u3044\u307e\u3059\u304c\u3068\u308a\u3042\u3048\u305a\u5909\u7570\u306b\u95a2\u3057\u3066\u306e\u9762\u767d\u305d\u3046\u306a\u6a5f\u80fd\u306f\u3053\u3093\u306a\u3068\u3053\u308d\u3067\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

        cBioPortal\u3068\u306f\u4f55\u304b cBioPortal for Cancer Genomics\u3068\u306f\u4f55\u304b\u3001\u3068\u3044\u3046\u554f\u3044\u306b\u3064\u3044\u3066\u306f\u30aa\u30ea\u30b8\u30ca\u30eb\u306e\u30b5\u30a4\u30c8\u3092\u307f\u3066\u3044\u305f\u3060\u304f\u306e\u304c\u901f\u3044\u306e\u3067\u3057\u3087\u3046\u3002\u516c\u958b\u3055\u308c\u305f\u907a\u4f1d\u5b50\u95a2\u9023\u60c5\u5831\uff08\u5909\u7570\u60c5\u5831\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u60c5…<\/p>\n","protected":false},"author":1,"featured_media":2509,"comment_status":"open","ping_status":"open","sticky":true,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[4],"tags":[],"class_list":["post-2489","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science"],"jetpack_featured_media_url":"https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2020\/09\/2B9A5C45-B0BC-4E03-BC89-F90893F366B1.png","jetpack_shortlink":"https:\/\/wp.me\/p9b6zl-E9","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/posts\/2489","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2489"}],"version-history":[{"count":0,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/posts\/2489\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/media\/2509"}],"wp:attachment":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2489"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2489"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2489"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}