{"id":2350,"date":"2020-04-11T22:26:25","date_gmt":"2020-04-11T13:26:25","guid":{"rendered":"https:\/\/plaza.umin.ac.jp\/~OIO\/?p=2350"},"modified":"2021-01-29T07:09:43","modified_gmt":"2021-01-28T22:09:43","slug":"covid19%e3%81%aespike%e8%9b%8b%e7%99%bd%e8%b3%aa%e3%81%ae%e5%8f%97%e5%ae%b9%e4%bd%93%e7%b5%90%e5%90%88%e3%83%89%e3%83%a1%e3%82%a4%e3%83%b3%e3%81%a8%e3%83%92%e3%83%88ace2","status":"publish","type":"post","link":"https:\/\/plaza.umin.ac.jp\/~OIO\/?p=2350","title":{"rendered":"COVID-19\u539f\u56e0\u30a6\u30a4\u30eb\u30b9\u306espike\u86cb\u767d\u8cea\u306e\u53d7\u5bb9\u4f53\u7d50\u5408\u30c9\u30e1\u30a4\u30f3\u3068\u30d2\u30c8ACE2"},"content":{"rendered":"<h1>\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u52d5\u753b<\/h1>\n<p>\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u80ba\u708eCOVID-19\u539f\u56e0\u30a6\u30a4\u30eb\u30b9\u306eSARS-CoV-2\u304c\u30d2\u30c8\u7d30\u80de\u306b\u4fb5\u5165\u3059\u308b\u969b\u306b\u7d50\u5408\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u30d2\u30c8\u7d30\u80de\u5074\u306e\u30bf\u30f3\u30d1\u30af\u8cea\uff08\u53d7\u5bb9\u4f53\uff09\u306fACE2\u3067\u3059\u3002\u3053\u306eACE\uff12\u3068\u30a6\u30a4\u30eb\u30b9\u5074\u306e\u7d50\u5408\u3059\u308b\u90e8\u4f4d\uff08\u53d7\u5bb9\u4f53\u7d50\u5408\u30c9\u30e1\u30a4\u30f3\uff09\u304c\u3069\u306e\u3088\u3046\u306b\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u306e\u304b\u3001\u76f4\u63a5\u89b3\u5bdf\u3059\u308b\u3053\u3068\u306f\u96e3\u3057\u3044\u3082\u306e\u3067\u3059\u3002\u76f4\u63a5\u898b\u308b\u306e\u304c\u96e3\u3057\u3044\u306e\u3067\u3042\u308c\u3070\u3001\u30b3\u30f3\u30d4\u30e5\u30fc\u30bf\u30fc\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3067\u88dc\u3046\u3068\u3044\u3046\u306e\u304c\u3001\u89b3\u5bdf\u306b\u8feb\u308b\u4e00\u3064\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u3059\u3002\u3053\u306e\u70b9\u306b\u3064\u3044\u3066\u30c7\u30d3\u30c3\u30c9\u30fb\u30b7\u30e7\u30a6\u3089\u306e<a href=\"https:\/\/www.deshawresearch.com\/resources_sarscov2.html\">\u30e2\u30ec\u30ad\u30e5\u30e9\u30fc\u30fb\u30c0\u30a4\u30ca\u30df\u30c3\u30af\u30fb\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u306e\u7d50\u679c<\/a>\u304c\u516c\u958b\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u30c7\u30fc\u30bf\u306f\u81a8\u5927\u3067\u3001\u79c1\u306f\u5165\u624b\u3057\u307e\u305b\u3093\u304c\u3001\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u306e\u7d50\u679c\u306e\u7d50\u5408\u3057\u3066\u3086\u304f\u69d8\u306e\u52d5\u753b\u3060\u3051\u8868\u793a\u3055\u305b\u3066\u3044\u305f\u3060\u304d\u307e\u3059\u3002SARS-CoV-2<\/p>\n<div style=\"width: 640px;\" class=\"wp-video\"><video class=\"wp-video-shortcode\" id=\"video-2350-1\" width=\"640\" height=\"360\" preload=\"metadata\" controls=\"controls\"><source type=\"video\/mp4\" src=\"https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2020\/04\/DESRES-Trajectory_sarscov2-10895671.mp4?_=1\" \/><a href=\"https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2020\/04\/DESRES-Trajectory_sarscov2-10895671.mp4\">https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2020\/04\/DESRES-Trajectory_sarscov2-10895671.mp4<\/a><\/video><\/div>\n<p>\u30d4\u30f3\u30af\u8272\u306e\u5206\u5b50\u304c\u30d2\u30c8ACE2\uff5e human ACE2 (hACE2)\uff5e\u3067\u3001\u30b0\u30ea\u30fc\u30f3\u304cSARS-CoV-2\u306espike\u86cb\u767d\u8cea\u306e\u53d7\u5bb9\u4f53\u7d50\u5408\u30c9\u30e1\u30a4\u30f3\u3067\u3059\u3002\uff5ereceptor-binding domain (RBD)\u3000\u5143\u306e\u8ad6\u6587<span id=\"8iLafV8uzmiVfrDMh3PQ6\" class=\"abt-citation noselect mceNonEditable\" data-reflist=\"[\" data-footnote=\"undefined\"><sup>1<\/sup><\/span>\u3067\u306f\u7d50\u6676\u69cb\u9020\u3092\u5f97\u3084\u3059\u304f\u3059\u308b\u69d8\u306b\u5c11\u3057\u4fee\u98fe\u3057\u3066\u3044\u307e\u3059\uff08\u5143\u306b\u306a\u3063\u305f\u69cb\u9020\u306f\u30a8\u30f3\u30c8\u30ea\u30fc6VW1<span id=\"8iLafV8uzmiVfrDMh3PQ6\" class=\"abt-citation noselect mceNonEditable\" data-reflist=\"[\" data-footnote=\"undefined\"><sup>1<\/sup><\/span>\uff09\uff5e<\/p>\n<p>\u9014\u4e2d\u3067\u5c0f\u3055\u306a\u767d\u3044\u68d2\u306e\u3088\u3046\u306a\u3082\u306e\u306b\u8d64\u3084\u9752\u306e\u5c0f\u3055\u306a\u70b9\u304c\u4ed8\u3044\u305f\u3082\u306e\u304c\u30cb\u30e7\u30ad\u30cb\u30e7\u30ad\u51fa\u3066\u304d\u3066\u3044\u307e\u3059\u304c\u3001\u4e21\u86cb\u767d\u8cea\u306e\u30a2\u30df\u30ce\u9178\u6b8b\u57fa\u3067\u3001\u7d50\u5408\u306b\u304b\u304b\u308f\u308b\u3082\u306e\u3060\u3051\u3092\u8868\u793a\u3059\u308b\u3088\u3046\u306b\u8a2d\u5b9a\u3057\u305f\u3082\u306e\u3068\u601d\u308f\u308c\u307e\u3059\u3002\u52d5\u753b\u306b\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u30ea\u30f3\u30af\u5148\u30db\u30fc\u30e0\u30da\u30fc\u30b8\u306b\u306f\u7d50\u5408\u90e8\u4f4d\u304c400\u307b\u3069\u306b\u5897\u3048\u308b\u3068\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u304c\u4f4e\u3044\u5b89\u5b9a\u3057\u305f\u72b6\u614b\u306b\u306a\u308b\u3088\u3046\u306a\u56f3\u3082\u63d0\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2020\/04\/ACE2_COVID19ReceptorBindingDomain.jpg\" class=\"aligncenter size-full wp-image-2354\" alt=\"\" width=\"800\" height=\"600\" srcset=\"https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2020\/04\/ACE2_COVID19ReceptorBindingDomain.jpg 800w, https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2020\/04\/ACE2_COVID19ReceptorBindingDomain-300x225.jpg 300w, https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2020\/04\/ACE2_COVID19ReceptorBindingDomain-700x525.jpg 700w, https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2020\/04\/ACE2_COVID19ReceptorBindingDomain-150x113.jpg 150w, https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2020\/04\/ACE2_COVID19ReceptorBindingDomain-768x576.jpg 768w, https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2020\/04\/ACE2_COVID19ReceptorBindingDomain-80x60.jpg 80w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/p>\n<div id=\"abt-bibliography\" class=\"abt-bibliography noselect mceNonEditable\" data-reflist=\"[\">\n<div id=\"abt-bibliography__container\" class=\"abt-bibliography__container\">\n<div id=\"1565977905\">\n<div class=\"csl-entry flush\">\n<div class=\"csl-left-margin\">1.<\/div>\n<div class=\"csl-right-inline\">Shang J, Ye G, Shi K, et al. Structural basis of receptor recognition by SARS-CoV-2. <i>Nature<\/i>. March 2020. <span class=\"abt-url\">[<\/span><span class=\"abt-url\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32225175\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed<\/a><\/span><span class=\"abt-url\">]<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u52d5\u753b \u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u80ba\u708eCOVID-19\u539f\u56e0\u30a6\u30a4\u30eb\u30b9\u306eSARS-CoV-2\u304c\u30d2\u30c8\u7d30\u80de\u306b\u4fb5\u5165\u3059\u308b\u969b\u306b\u7d50\u5408\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u30d2\u30c8\u7d30\u80de\u5074\u306e\u30bf\u30f3\u30d1\u30af\u8cea\uff08\u53d7\u5bb9\u4f53\uff09\u306fACE2\u3067\u3059\u3002\u3053\u306eACE\uff12\u3068\u30a6\u30a4\u30eb\u30b9\u5074\u306e\u7d50\u5408&#8230;<\/p>\n","protected":false},"author":1,"featured_media":2354,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[4],"tags":[],"class_list":["post-2350","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science"],"jetpack_featured_media_url":"https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2020\/04\/ACE2_COVID19ReceptorBindingDomain.jpg","jetpack_shortlink":"https:\/\/wp.me\/p9b6zl-BU","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/posts\/2350","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2350"}],"version-history":[{"count":0,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/posts\/2350\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/media\/2354"}],"wp:attachment":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2350"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2350"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2350"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}