{"id":2259,"date":"2020-02-16T22:22:12","date_gmt":"2020-02-16T13:22:12","guid":{"rendered":"https:\/\/plaza.umin.ac.jp\/~OIO\/?p=2259"},"modified":"2020-05-14T09:51:48","modified_gmt":"2020-05-14T00:51:48","slug":"covid-2019-%e6%96%b0%e5%9e%8b%e3%82%b3%e3%83%ad%e3%83%8a%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9%e3%81%ae%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af%e8%b3%aa%e3%81%ae%e6%a7%8b%e9%80%a0","status":"publish","type":"post","link":"https:\/\/plaza.umin.ac.jp\/~OIO\/?p=2259","title":{"rendered":"COVID-19 \u306e\u539f\u56e0\u75c5\u539f\u4f53\u3067\u3042\u308b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9SARS-CoV-2\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u69cb\u9020"},"content":{"rendered":"<p><a href=\"https:\/\/www.wwpdb.org\/pdb?id=pdb_00006lu7\">COVID-19\u306e\u539f\u56e0\u30a6\u30a4\u30eb\u30b9\u3067\u3042\u308bSARS-CoV-2\u306eMpro\u3068\u3044\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u69cb\u9020<\/a>\u304cPDB\u306b\u516c\u958b\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u30a8\u30f3\u30c8\u30ea\u306f6LU7\u3002PDB\u306e\u89e3\u8aac\u306e\u66f8\u304d\u65b9\u304b\u3089\u3059\u308b\u3068\u3001\u3053\u306e\u30a6\u30a4\u30eb\u30b9\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u4ed6\u306b\u3082\u69cb\u9020\u304c\u6c7a\u5b9a\u3055\u308c\u3066\u3044\u308b\u5206\u5b50\u304c\u3042\u308b\u3051\u308c\u3069\u3082\u3001\uff08\u7121\u6599\u3067\u7121\u6761\u4ef6\u306b\uff09\u516c\u958b\u3055\u308c\u3066\u3044\u308b\u306e\u306f\u3053\u308c\u3060\u3051\u3060\u3068\u3044\u3046\u69d8\u306b\u53d6\u308c\u307e\u3059\uff0a\uff11\u3002\u65b0\u3057\u3044\u3082\u306e\u3092\u767a\u898b\u3057\u305f\u3068\u3057\u3066\u3001\u305d\u306e\u77e5\u8ca1\u3092\u56f2\u3044\u8fbc\u3093\u3067\u81ea\u5206\u9054\u306e\u91d1\u5132\u3051\u306b\u3059\u308b\u3068\u3044\u3046\u306e\u306f20\u4e16\u7d00\u7684\u306a\u30a2\u30e1\u30ea\u30ab\u30f3\u30c9\u30ea\u30fc\u30e0\u3067\u3042\u3063\u3066\u3001\u3082\u306e\u304c\u4e0d\u8db3\u3057\u3066\u3044\u305f\u9803\u306e\u8003\u3048\u65b9\u3067\u6642\u4ee3\u9045\u308c\u3067\u306a\u3044\u304b\u3068\u3002\u767a\u898b\u3057\u305f\u3082\u306e\u3067\u793e\u4f1a\u306e\u69d8\u3005\u306a\u554f\u984c\u3092\u89e3\u6c7a\u3057\u305f\u308a\u3001\u4e16\u306e\u4e2d\u3092\u826f\u304f\u3059\u308b\u69d8\u306b\u3068\u3044\u3046\u3088\u3046\u306a\u8003\u3048\u65b9\u304c\u5e83\u304c\u3089\u306a\u3044\u304b\u306a\u3041\u3002\u305d\u308c\u306f\u3055\u3066\u304a\u304d\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u306b\u30d0\u30ad\u30e5\u30ed\u3068\u6606\u866b\u7d30\u80de\u3092\u4f7f\u3063\u305f\u7cfb\u304c\u591a\u3044\u4e2d\u3001\u3053\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u79c1\u304c\u6163\u308c\u89aa\u3057\u3093\u3060BL21(DE3)\u3067\u767a\u73fe\u3057\u3066\u3044\u307e\u3059\u3002\u516c\u958b\u3055\u308c\u305f\u3082\u306e\u3092\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u3002\uff08\u30ec\u30f3\u30c0\u30ea\u30f3\u30b0\u306f\u79c1\u304c\u3057\u307e\u3057\u305f\u304c\u3001\u69cb\u9020\u306fPDB 6LU7\u3092\u4f7f\u7528\u3057\u3066\u3044\u307e\u3059\uff09<\/p>\n<p>\uff0a\uff11\u3000\u305d\u306e\u5f8c\u591a\u304f\u306e\u69cb\u9020\u304c\u516c\u958b\u3055\u308c\u3066\u3044\u307e\u3059\u3002<a href=\"https:\/\/plaza.umin.ac.jp\/~OIO\/blog\/2020\/04\/11\/covid19%e3%81%aespike%e8%9b%8b%e7%99%bd%e8%b3%aa%e3%81%ae%e5%8f%97%e5%ae%b9%e4%bd%93%e7%b5%90%e5%90%88%e3%83%89%e3%83%a1%e3%82%a4%e3%83%b3%e3%81%a8%e3%83%92%e3%83%88ace2\/\">ACE2\u3068\u30a6\u30a4\u30eb\u30b9\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7d50\u5408\u306b\u3064\u3044\u3066\u3092\u5225\u8a18\u4e8b<\/a>\u306b\u8ffd\u52a0\u3057\u307e\u3057\u305f\u3002(2020.04.11)<\/p>\n<p>SARS-CoV-2\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b93CL\u30d2\u30c9\u30ed\u30e9\u30fc\u30bc\uff08Mpro\uff09\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3001\u767b\u9332\u3055\u308c\u305f\u69cb\u9020\u5168\u4f53\uff081\u5206\u5b50\u5206\uff09\u3092\u8868\u793a\u3057\u3066\u3044\u307e\u3059\u3002Mpro\uff08\u767d\uff09\u4ee5\u5916\u306b\u30aa\u30ea\u30b4\u30da\u30d7\u30c1\u30c9\u69d8\u306e\u963b\u5bb3\u85ac\uff08\u8584\u7d2b\uff09\u304c\u4e00\u7dd2\u306b\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2020\/02\/Covid2019A.png\"><img loading=\"lazy\" decoding=\"async\" style=\"display: inline; background-image: none;\" title=\"Covid2019A\" src=\"https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2020\/02\/Covid2019A_thumb.png\" alt=\"Covid2019A\" width=\"244\" height=\"184\" border=\"0\" \/><\/a><\/p>\n<p>\u963b\u5bb3\u85ac\u4ed8\u8fd1\u304c\u898b\u3048\u3084\u3059\u3044\u3088\u3046\u306b\u8584\u5207\u308a(Slab)\u306b\u3057\u3066\u307f\u307e\u3059\u3002<\/p>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2020\/02\/Covid2019C.png\"><img loading=\"lazy\" decoding=\"async\" style=\"display: inline; background-image: none;\" title=\"Covid2019C\" src=\"https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2020\/02\/Covid2019C_thumb.png\" alt=\"Covid2019C\" width=\"244\" height=\"184\" border=\"0\" \/><\/a><\/p>\n<p>\u4e21\u5206\u5b50\u9593\u3067\u6c34\u7d20\u7d50\u5408\u304c\u3042\u308a\u305d\u3046\u306a\u3068\u3053\u308d\u3092\u898b\u3084\u3059\u3044\u8868\u793a\u306b\u3057\u3066\u307f\u307e\u3057\u305f\u3002\u3061\u3083\u3093\u3068\u306f\u307e\u308a\u8fbc\u3093\u3067\u3044\u308b\u3088\u3046\u306a\u611f\u3058\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2020\/02\/Covid2019B.png\"><img loading=\"lazy\" decoding=\"async\" style=\"display: inline; background-image: none;\" title=\"Covid2019B\" src=\"https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2020\/02\/Covid2019B_thumb.png\" alt=\"Covid2019B\" width=\"244\" height=\"184\" border=\"0\" \/><\/a><\/p>\n<p><a href=\"https:\/\/www.wwpdb.org\/news\/news?year=2020#5e39e03fa5007a04a313edc3\">PDB news<\/a>\u306b\u3088\u308b\u3068\u3001\u300cPDB\u30a2\u30fc\u30ab\u30a4\u30d6\u306e\u30a8\u30f3\u30c8\u30ea\u30fc\u3068\u6bd4\u8f03\u3059\u308b\u3068\u3001\u5c11\u306a\u304f\u3068\u308290%\u306e\u914d\u5217\u76f8\u540c\u6027\u3092\u6301\u3064\u86cb\u767d\u8cea\u304c95\u4ef6\u306ePDB\u30a8\u30f3\u30c8\u30ea\u30fc\u3067\u540c\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u3053\u308c\u3089\u306e\u95a2\u9023\u86cb\u767d\u8cea\u69cb\u9020\u306b\u306f\u3001\u7d0430\u500b\u306e\u7570\u306a\u308b\u4f4e\u5206\u5b50\u963b\u5bb3\u85ac\u304c\u542b\u307e\u308c\u3066\u304a\u308a\u3001\u65b0\u85ac\u306e\u767a\u898b\u306b\u5f79\u7acb\u3064\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u300d\u3068\u306e\u3053\u3068\u3002\u305d\u308c\u3089\u306e\u963b\u5bb3\u85ac\u306f\u6cbb\u7642\u85ac\u306e\u958b\u767a\u306e\u51fa\u767a\u70b9\u306b\u306a\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>COVID-19\u306e\u539f\u56e0\u30a6\u30a4\u30eb\u30b9\u3067\u3042\u308bSARS-CoV-2\u306eMpro\u3068\u3044\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u69cb\u9020\u304cPDB\u306b\u516c\u958b\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u30a8\u30f3\u30c8\u30ea\u306f6LU7\u3002PDB\u306e\u89e3\u8aac\u306e\u66f8\u304d\u65b9\u304b\u3089\u3059\u308b\u3068\u3001\u3053\u306e\u30a6\u30a4\u30eb\u30b9\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u4ed6\u306b\u3082\u69cb\u9020\u304c\u6c7a\u5b9a\u3055\u308c\u3066\u3044&#8230;<\/p>\n","protected":false},"author":1,"featured_media":2255,"comment_status":"open","ping_status":"open","sticky":true,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[4],"tags":[],"class_list":["post-2259","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science"],"jetpack_featured_media_url":"https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2020\/02\/Covid2019C-e1581859104262.png","jetpack_shortlink":"https:\/\/wp.me\/p9b6zl-Ar","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/posts\/2259","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2259"}],"version-history":[{"count":0,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/posts\/2259\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/media\/2255"}],"wp:attachment":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2259"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2259"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2259"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}