{"id":222,"date":"2017-09-20T21:09:34","date_gmt":"2017-09-20T12:09:34","guid":{"rendered":"https:\/\/plaza.umin.ac.jp\/~OIO\/?p=222"},"modified":"2017-09-21T21:14:47","modified_gmt":"2017-09-21T12:14:47","slug":"tragedy-perseverance-and-chance-the-story-of-car-t-therapy","status":"publish","type":"post","link":"https:\/\/plaza.umin.ac.jp\/~OIO\/?p=222","title":{"rendered":"Tragedy, Perseverance, and Chance \u2014 The Story of CAR-T Therapy"},"content":{"rendered":"<h6><a href=\"http:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMp1711886\">Tragedy, Perseverance, and Chance \u2014 The Story of CAR-T Therapy<\/a><\/h6>\n<p>\u6700\u8fd1\u306fCAR-T\u6280\u8853\u3092\u7528\u3044\u305f\u533b\u85ac\u54c1\uff08\u518d\u751f\u533b\u7642\u88fd\u54c1\u7b49\u3092\u542b\u3080\uff09<wbr \/>\u306e\u958b\u767a\u306f\u5185\u8cc7\u3092\u542b\u3081\u591a\u304f\u306e\u88fd\u85ac\u4f01\u696d\u3067\u9032\u3081\u3089\u308c\u3066\u3044\u3066\u3001<wbr \/>\u79c1\u304c\u30a2\u30c9\u30d0\u30a4\u30b6\u30fc\u3092\u52d9\u3081\u308b\u88fd\u85ac\u4f01\u696d\u3067\u3082\u7cbe\u529b\u7684\u306b\u52d5\u3044\u3066\u3044\u308b\u306e\u3092\u611f<wbr \/>\u3058\u307e\u3059\u3002\uff08\u79c1\u306f\u958b\u767a\u306b\u306f\u304b\u304b\u308f\u3063\u3066\u3044\u307e\u305b\u3093\u304c\uff09\u304b\u3053\u306b<wbr \/>\u95a2\u9023\u306e\u5b66\u8853\u96c6\u4f1a\u7b49\u3067\u3082\u63d0\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3001Eily\u306e\u8a71\u306f\u3001<wbr \/>\u4f55\u56de\u304b\u805e\u3044\u305f\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u3067\u3082\u3001<wbr \/>\u305d\u308c\u3068\u306f\u5225\u306e\u767b\u5834\u4eba\u7269\u306e\u8a71\u306f\u3001\u3053\u306e\u8ad6\u6587\u3067\u521d\u3081\u3066\u77e5\u308a\u307e\u3057\u305f\u3002<br \/>\n\u30da\u30f3\u30b7\u30eb\u30d0\u30cb\u30a2\u5927\u5b66\u306eCarl June\u306f\u3001\u901a\u5e38\u306a\u3089\u7814\u7a76\u958b\u767a\u3092\u3042\u304d\u3089\u3081\u308b\u3088\u3046\u306a\u5834\u9762\u3067\u3001<wbr \/>\u7c98\u308a\u5f37\u3055\u3092\u898b\u305b\u307e\u3059\u3002\u59bb\u3092\u5375\u5de3\u304c\u3093\u3067\u4ea1\u304f\u3057\u305f\u3053\u3068\u304b\u3089\u304f\u308b\u3001<wbr \/>\u65b0\u3057\u3044\u6280\u8853\u306b\u3088\u308b\u6cbb\u7642\u3092\u958b\u767a\u3059\u308b\u3053\u3068\u306b\u304b\u3051\u308b\u57f7\u5ff5\u306e\u3088\u3046\u306a\u3082\u306e\u304c<wbr \/>\u305d\u308c\u3092\u652f\u3048\u3066\u3044\u305f\u3088\u3046\u3067\u3059\u3002<br \/>\n\u7fa9\u7406\u306e\u5a18\u3092\u4e73\u304c\u3093\u3067\u4ea1\u304f\u3057\u305f\u30d0\u30fc\u30d0\u30e9\u3068\u30a8\u30c9\u30ef\u30fc\u30c9\u30fb<wbr \/>\u30cd\u30c3\u30bf\u30fc\u304c\u65b0\u898f\u306e\u6cbb\u7642\u6cd5\u3092\u958b\u767a\u3059\u308b\u305f\u3081\u306e\u30a2\u30e9\u30a4\u30a2\u30f3\u30b9(AGCT\u3000-\u5236\u9650\u9175\u7d20Alu1\u3067\u30ad\u30ec\u305d\u3046\u306a\u540d\u79f0) \u3092\u7acb\u3061\u4e0a\u3052\u3001\u3053\u306e\u7814\u7a76\u306b$1,000,<wbr \/>000\u3082\u306e\u8cc7\u91d1\u63d0\u4f9b\u3057\u307e\u3057\u305f\u3002\u306a\u304b\u306a\u304b\u3001<wbr \/>\u3046\u307e\u304f\u3044\u304f\u304b\u3069\u3046\u304b\u308f\u304b\u3089\u306a\u3044\u3088\u3046\u306a\u4e8b\u696d\u306b\u51fa\u8cc7\u3067\u304d\u308b\u3088\u3046\u306a\u91d1\u984d<wbr \/>\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<wbr \/>\u53d7\u3051\u53d6\u3063\u3066\u7814\u7a76\u958b\u767a\u3059\u308b\u5074\u3082\u305d\u308c\u306a\u308a\u306b\u80a9\u306e\u8377\u306e\u91cd\u3044\u8a71\u3060\u3063\u305f\u3060\u308d<wbr \/>\u3046\u3068\u601d\u3044\u307e\u3059\u3002<br \/>\n\u30da\u30f3\u30b7\u30eb\u30d0\u30cb\u30a2\u5927\u5b66\u3067\u3053\u306e\u6cbb\u7642\u3092\u53d7\u3051\u305f\u75c7\u4f8b\u306e\u81e8\u5e8a\u7d4c\u904e\u3092\u898b\u307e\u3059\u3068<wbr \/>\u3001<wbr \/>\u666e\u901a\u306a\u3089\u4ea1\u304f\u306a\u3063\u3066\u3082\u304a\u304b\u3057\u304f\u306a\u3044\u3088\u3046\u306a\u5371\u967a\u306a\u72b6\u614b\u306b\u306a\u3063\u3066\u3044\u308b<wbr \/>\u306e\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001<wbr \/>\u5947\u8de1\u7684\u306a\u3068\u8a00\u3063\u3066\u3044\u3044\u307b\u3069\u306e\u5fa9\u6d3b\u3092\u898b\u305b\u308b\u75c7\u4f8b\u304c\u591a\u304f\u3044\u307e\u3059\u3002<wbr \/>\u304b\u304b\u308f\u3063\u3066\u3044\u308b\u4eba\u305f\u3061\u304c\u57f7\u5ff5\u3092\u6301\u3063\u3066\u30b1\u30a2\u3057\u3066\u3044\u305f\u306e\u304b\u3082\u3057\u308c\u307e\u305b<wbr \/>\u3093\u3002\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u30b9\u30c8\u30fc\u30e0\u306b\u898b\u821e\u308f\u308c\u3001IL-<wbr \/>6\u30ec\u30d9\u30eb\u306e\u4e0a\u6607\u3092\u898b\u305f\u969b\u306b\u3001IL-6 pathway\u3092\u6a19\u7684\u3068\u3059\u308b\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u3067\u3042\u308b\u30c8\u30b7\u30ea\u30ba\u30de<wbr \/>\u30d6\u304c\u4ed6\u306e\u75be\u60a3\u306b\u5bfe\u3059\u308b\u9069\u5fdc\u3067\u306f\u3042\u308a\u307e\u3059\u304c\u627f\u8a8d\u3055\u308c\u3001<wbr \/>\u533b\u85ac\u54c1\u30b0\u30ec\u30fc\u30c9\u306e\u5e02\u5834\u3067\u8abf\u9054\u3067\u304d\u308b\u72b6\u614b\u306b\u3042\u3063\u305f\u306e\u306f\u6642\u4ee3\u306e\u3088\u3044\u3081<wbr \/>\u3050\u308a\u3042\u308f\u305b\u3060\u3063\u305f\u3060\u308d\u3046\u3068\u601d\u3044\u307e\u3059\u3002<br \/>\n\u3061\u306a\u307f\u306b\u3001\u9014\u4e2d\u3067Gelsinger\u541b\u306e\u8a71\u304c\u5f15\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002<wbr \/>\u300c\u5f7c\u304c\u4ea1\u304f\u306a\u3063\u305f\u3053\u3068\u3067\u907a\u4f1d\u5b50\u6cbb\u7642\u306e\u958b\u767a\u304c10\u5e74\u306f\u9045\u308c\u305f\u300d<wbr \/>\u3068\u3044\u3046\u3088\u3046\u306a\u8da3\u65e8\u3067\u5f15\u7528\u3055\u308c\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u5f53\u6642\u79c1\u306f\u3001<wbr \/>\u3053\u3046\u3057\u305f\u6cbb\u7642\u6cd5\u306e\u76e3\u7763\u5b98\u5e81\u306eFDA\u306b\u52e4\u3081\u3066\u3044\u3066\u3001<wbr \/>\u3042\u308b\u65e5\u51fa\u52e4\u3059\u308b\u3068\u30e1\u30c7\u30a3\u30a2\u304cFDA\u306e\u5165\u308a\u53e3\u4ed8\u8fd1\u306b\u96c6\u307e\u3063\u3066\u3044\u305f\u306e<wbr \/>\u3092\u601d\u3044\u51fa\u3057\u307e\u3059\u3002\u3053\u306e\u8ad6\u6587\u306b\u66f8\u304b\u308c\u3066\u3044\u308b\u3053\u3068\u306b\u3001<wbr \/>\u79c1\u306f\u76f4\u63a5\u304b\u304b\u308f\u3063\u3066\u306f\u3044\u307e\u305b\u3093\u304c\u3001<wbr \/>\u6bd4\u8f03\u7684\u79c1\u304c\u3044\u308b\u7a7a\u9593\u306e\u6bd4\u8f03\u7684\u8fd1\u3044\u3068\u3053\u308d\u3067\u8d77\u304d\u305f\u4e8b\u306a\u3093\u3060\u306a\u3068\u611f\u3058<wbr \/>\u307e\u3059\u3002<br \/>\n\u6700\u5f8c\u306b\u3001\u3044\u3044\u8a00\u8449\u304c\u66f8\u304b\u308c\u3066\u3044\u308b\u306e\u3067\u5f15\u7528\u3057\u307e\u3059\u3002\u300cChance favors the prepared mind\u300d\u3010\u30c1\u30e3\u30f3\u30b9\u306f\u6e96\u5099\u3055\u308c\u305f\u5fc3\u3092\u597d\u3080\u3011 \u30c1\u30e3\u30f3\u30b9\u306b\u5099\u3048\u3066\u6e96\u5099\u3057\u3066\u304a\u304d\u307e\u3057\u3087\u3046\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tragedy, Perseverance, and Chance \u2014 The Story of CAR-T Therapy \u6700\u8fd1\u306fCAR-T\u6280\u8853\u3092\u7528\u3044\u305f\u533b\u85ac\u54c1\uff08\u518d\u751f\u533b\u7642\u88fd\u54c1\u7b49\u3092\u542b\u3080\uff09\u306e\u958b\u767a\u306f\u5185\u8cc7\u3092\u542b\u3081\u591a\u304f\u306e\u88fd\u85ac\u4f01\u696d\u3067\u9032&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[5,4],"tags":[],"class_list":["post-222","post","type-post","status-publish","format-standard","hentry","category-miscellaneous","category-science"],"jetpack_featured_media_url":"","jetpack_shortlink":"https:\/\/wp.me\/p9b6zl-3A","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/posts\/222","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=222"}],"version-history":[{"count":0,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/posts\/222\/revisions"}],"wp:attachment":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=222"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=222"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=222"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}