{"id":1873,"date":"2019-01-26T11:27:04","date_gmt":"2019-01-26T02:27:04","guid":{"rendered":"https:\/\/plaza.umin.ac.jp\/~OIO\/?p=1873"},"modified":"2019-01-27T16:15:17","modified_gmt":"2019-01-27T07:15:17","slug":"%e3%82%a4%e3%83%b3%e3%83%95%e3%83%ab%e3%82%a8%e3%83%b3%e3%82%b6%e6%b2%bb%e7%99%82%e8%96%ac%e3%81%ab%e8%80%90%e6%80%a7%e3%81%ae%e3%82%a4%e3%83%b3%e3%83%95%e3%83%ab%e3%82%a8%e3%83%b3%e3%82%b6%e3%82%a6","status":"publish","type":"post","link":"https:\/\/plaza.umin.ac.jp\/~OIO\/?p=1873","title":{"rendered":"\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u6cbb\u7642\u85ac\u306b\u8010\u6027\u306e\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u30a6\u30a4\u30eb\u30b9\u306e\u30ad\u30e3\u30c3\u30d7\u4f9d\u5b58\u6027\u30a8\u30f3\u30c9\u30cc\u30af\u30ec\u30a2\u30fc\u30bc"},"content":{"rendered":"

\u8010\u6027\u30a6\u30a4\u30eb\u30b9<\/h1>\n

\u65b0\u898f\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u6cbb\u7642\u85ac\u306b\u8010\u6027\u3092\u6301\u3064\u3068\u3044\u3046\u30a6\u30a4\u30eb\u30b9\u304c\u3001\u305d\u306e\u65b0\u898f\u6cbb\u7642\u85ac\u3092\u4f7f\u7528\u3057\u305f\u60a3\u8005\u3055\u3093\u304b\u3089\u691c\u51fa\u3055\u308c\u305f\u3068\u3044\u3046\u4e8b\u3067\u30012018.1.25\u306b\u30cb\u30e5\u30fc\u30b9\u304c\u6d41\u308c\u307e\u3057\u305f\u3002\u305d\u306e\u6cbb\u7642\u85ac\u306f\u3001\u30ad\u30e3\u30c3\u30d7\u4f9d\u5b58\u6027\u30a8\u30f3\u30c9\u30cc\u30af\u30ec\u30a2\u30fc\u30bc (cap-dependent endonuclease) \u963b\u5bb3\u85ac\u3067\u3001\u4e00\u822c\u540d\u30d0\u30ed\u30ad\u30b5\u30d3\u30eb\u30de\u30eb\u30dc\u30ad\u30b7\u30eb (baloxavir marboxil) \u3068\u547c\u3070\u308c\u308b\u533b\u85ac\u54c1\u3067\u3059\u3002\u30cb\u30e5\u30fc\u30b9\u3067\u306f\u3069\u3046\u3044\u3063\u305f\u691c\u67fb\u3092\u3057\u3066\u300c\u8010\u6027\u300d\u3092\u78ba\u5b9a\u3057\u305f\u304b\u306f\u8ff0\u3079\u3089\u308c\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u30bd\u30fc\u30b9\u306e\u60c5\u5831<\/a>\u306b\u3088\u308b\u3068\u30bf\u30fc\u30b2\u30c3\u30c8\u5206\u5b50\u3067\u3042\u308b\u30ad\u30e3\u30c3\u30d7\u4f9d\u5b58\u6027\u30a8\u30f3\u30c9\u30cc\u30af\u30ec\u30a2\u30fc\u30bc\u306e\u5909\u7570\u3067\u3042\u308bPA I38T\u3001I38F\u7b49\u3092\u76e3\u8996\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u8ff0\u3079\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u5909\u7570\u306fNCBI\u306e\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306b\u4ee5\u524d\u3088\u308a\u5b58\u5728\u3057\u3066\u3044\u307e\u3059\u306e\u3067\u3001\u666e\u901a\u306b\u4e16\u306e\u4e2d\u306b\u3044\u308b\u30a6\u30a4\u30eb\u30b9\u304c\u6301\u3063\u3066\u3044\u305f\u5909\u7570\u3060\u308d\u3046\u3068\u601d\u308f\u308c\u307e\u3059\u3002\u305d\u3057\u3066\u3001\u6cbb\u9a13\u6642\u306b\u306f10\uff05\u5f31\u306e\u88ab\u9a13\u8005\u306b\u3053\u306e\u5909\u7570\u304c\u898b\u3089\u308c\u307e\u3057\u305f\u3002\u6cbb\u9a13\u306e\u60c5\u5831\u306b\u3088\u308a\u307e\u3059\u3068\u3001\u3053\u306e\u5909\u7570\u3092\u6301\u3063\u3066\u3044\u308b\u30a6\u30a4\u30eb\u30b9\u306b\u304b\u304b\u3063\u305f\u88ab\u9a13\u8005\u3067\u306f\u3001\u6cbb\u76425\u65e5\u76ee\u30019\u65e5\u76ee\u306b\u30a6\u30a4\u30eb\u30b9\u304c\u691c\u51fa\u3055\u308c\u305f\u5272\u5408\u304c\u91ce\u751f\u578b\u306e\u30a6\u30a4\u30eb\u30b9\u306b\u304b\u304b\u3063\u305f\u88ab\u9a13\u8005\u3088\u308a\u9ad8\u304f\u306a\u308a\u307e\u3057\u305f\u30021<\/sup><\/span><\/p>\n

\u3053\u306e\u6cbb\u9a13\u30c7\u30fc\u30bf\u3067\u5c11\u3057\u76ee\u306b\u7559\u307e\u308b\u306e\u306f\u3001\u30d7\u30e9\u30bb\u30dc\u6cbb\u7642\u7fa4\u3088\u308a\u5909\u7570\u30a6\u30a4\u30eb\u30b9\u306b\u5bfe\u3059\u308b\u5b9f\u85ac\u6cbb\u7642\u7fa4\u306e\u65b9\u304c\u30a6\u30a4\u30eb\u30b9\u304c\u691c\u51fa\u3055\u308c\u308b\u88ab\u9a13\u8005\u306e\u5272\u5408\u304c\u9ad8\u304f\u306a\u308b\u69d8\u306b\u898b\u3048\u308b\u70b9\u3067\u3059\u3002\u529b\u4fa1\u306e\u30b0\u30e9\u30d5\u3092\u898b\u3066\u3044\u308b\u3068\u3001\u8010\u6027\u30a6\u30a4\u30eb\u30b9\u306f\u4e00\u65e6\u529b\u4fa1\u304c\u4f4e\u4e0b\u3057\u305f\u5f8c\u30016\u65e5\u76ee\u3042\u305f\u308a\u306b\u518d\u3073\u529b\u4fa1\u304c\u4e0a\u6607\u3059\u308b\u3088\u3046\u306a\u30ab\u30fc\u30d6\u3092\u63cf\u3044\u3066\u898b\u3048\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u30c7\u30fc\u30bf\u304c\u3001\u81e8\u5e8a\u7684\u306b\u6df1\u523b\u306a\u554f\u984c\u306a\u306e\u304b\u306f\u4f55\u3068\u3082\u8a00\u3048\u307e\u305b\u3093\u3002\u8a73\u3057\u304f\u77e5\u308a\u305f\u3044\u65b9\u306f\u539f\u84571<\/sup><\/span>\u3084\u8ca9\u58f2\u30e1\u30fc\u30ab\u30fc\u306e\u8cc7\u6750<\/a>\u3092\u898b\u3066\u3054\u691c\u8a0e\u304f\u3060\u3055\u3044\u3002<\/p>\n

PA\u306b\u8010\u6027\u5909\u7570\u304c\u3042\u308b\u3068\u533b\u85ac\u54c1\u304c\u5168\u304fPA\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u306a\u3044\u306e\u304b\uff1f<\/h2>\n

PA\u5206\u5b50\u306e\u7d50\u6676\u69cb\u9020\u304c\u516c\u958b\u3055\u308c\u3066\u3044\u307e\u30592<\/sup><\/span>\u306e\u3067\u3001\u3053\u308c\u3092\u5229\u7528\u3057\u8010\u6027\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u8feb\u308b\u3002\u3068\u304b\u8a00\u3046\u305f\u3044\u305d\u3046\u306a\u8a71\u3067\u306f\u306a\u304f\u3001\u3068\u308a\u3042\u3048\u305a\u773a\u3081\u3066\u307f\u307e\u3057\u305f\u3002\u9ec4\u8272\u304cbaloxavir acid\u3067\u3059\u3002\uff08\u533b\u85ac\u54c1\u306ebaloxavir marboxil\u3068\u306f\u3001\u82e5\u5e72\u69cb\u9020\u304c\u9055\u3044\u307e\u3059\uff09\u9752\u304c\u6d3b\u6027\u4e2d\u5fc3\u4ed8\u8fd1\u306b\u5074\u9396\u3092\u51fa\u3057\u3066\u3044\u308b\u30a2\u30df\u30ce\u9178\u6b8b\u57fa\u3002\u305d\u3057\u3066\u3001\u30d4\u30f3\u30af\u304c\u5909\u7570\u304c\u3042\u308b\u5834\u6240\u3067\u3059\u3002<\/p>\n

\u91ce\u751f\u578b\u69cb\u9020<\/h4>\n

\"\"<\/p>\n

PA I38T \u306e\u8010\u6027\u3092\u6709\u3059\u308b\u69cb\u9020<\/h4>\n

\"\"<\/p>\n

I38T\u306e\u5909\u7570\u304c\u3042\u3063\u3066\u3082\u3001\u4f5c\u7528\u70b9\u306bbaloxavir acid\u304c\u4e00\u898b\u304d\u3061\u3093\u3068\u30cf\u30de\u3063\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002\u6c34\u7d20\u7d50\u5408\u3092\u4f5c\u3063\u3066\u3044\u308b\u3067\u3042\u308d\u3046\u539f\u5b50\u9593\u306e\u8ddd\u96e2\u304c\u5fae\u5999\u306b\u9055\u3046\u306e\u3067\u3001\u30d5\u30a1\u30f3\u30c7\u30eb\u30ef\u30fc\u30eb\u30b9\u529b\u304c\u9055\u3044\u3001\u7d50\u5408\u306e\u5f37\u3055\u306b\u5dee\u304c\u51fa\u308b\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u79d1\u5b66\u7684\u306b\u53b3\u5bc6\u306a\u30c7\u30a3\u30b9\u30ab\u30c3\u30b7\u30e7\u30f3\u306f\u3001\u8ad6\u65872<\/sup><\/span>\u3092\u3054\u78ba\u8a8d\u304f\u3060\u3055\u3044\u3002<\/p>\n

\u304a\u904a\u3073\u3067\u3001\u3044\u3064\u3082\u3088\u308a\u591a\u3081\u306b\u56de\u3057\u3066\u307f\u307e\u3057\u305f\u3002<\/p>\n

https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2019\/01\/I38T.mp4<\/a><\/video><\/div>\n
\n
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\n
1.<\/div>\n
Hayden F, Sugaya N, Hirotsu N, et al. Baloxavir Marboxil for Uncomplicated Influenza in Adults and Adolescents. N Engl J Med<\/i>. 2018;379(10):913-923. [PubMed<\/a>]<\/span><\/div>\n<\/div>\n<\/div>\n
\n
\n
2.<\/div>\n
Omoto S, Speranzini V, Hashimoto T, et al. Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil. Sci Rep<\/i>. 2018;8(1):9633. [PubMed<\/a>]<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u8010\u6027\u30a6\u30a4\u30eb\u30b9 \u65b0\u898f\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u6cbb\u7642\u85ac\u306b\u8010\u6027\u3092\u6301\u3064\u3068\u3044\u3046\u30a6\u30a4\u30eb\u30b9\u304c\u3001\u305d\u306e\u65b0\u898f\u6cbb\u7642\u85ac\u3092\u4f7f\u7528\u3057\u305f\u60a3\u8005\u3055\u3093\u304b\u3089\u691c\u51fa\u3055\u308c\u305f\u3068\u3044\u3046\u4e8b\u3067\u30012018.1.25\u306b\u30cb\u30e5\u30fc\u30b9\u304c\u6d41\u308c\u307e\u3057\u305f\u3002\u305d\u306e\u6cbb\u7642\u85ac\u306f\u3001\u30ad\u30e3\u30c3\u30d7\u4f9d\u5b58\u6027\u30a8\u30f3\u30c9\u30cc\u30af\u30ec\u30a2\u30fc\u30bc (c…<\/p>\n","protected":false},"author":1,"featured_media":1877,"comment_status":"open","ping_status":"open","sticky":true,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[4],"tags":[],"class_list":["post-1873","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science"],"jetpack_featured_media_url":"https:\/\/plaza.umin.ac.jp\/~OIO\/wp-content\/uploads\/2019\/01\/I38T.png","jetpack_shortlink":"https:\/\/wp.me\/p9b6zl-ud","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/posts\/1873","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1873"}],"version-history":[{"count":0,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/posts\/1873\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/media\/1877"}],"wp:attachment":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1873"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1873"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1873"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}