{"id":132,"date":"2017-09-16T17:39:26","date_gmt":"2017-09-16T08:39:26","guid":{"rendered":"https:\/\/plaza.umin.ac.jp\/~OIO\/?p=132"},"modified":"2017-09-16T17:39:26","modified_gmt":"2017-09-16T08:39:26","slug":"nivolumab-and-egfr-tki","status":"publish","type":"post","link":"https:\/\/plaza.umin.ac.jp\/~OIO\/?p=132","title":{"rendered":"Nivolumab and EGFR-TKI"},"content":{"rendered":"<p><a href=\"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php\/science\/\">EGFR-TKI \u00a0\u3068\u3000Nivolumab\u306e\u5206\u5b50\u306e\u7acb\u4f53\u69cb\u9020<\/a>\u3092\u63b2\u8f09\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>EGFR-\u30c1\u30ed\u30b7\u30f3\u30ea\u30f3\u9178\u5316\u9175\u7d20\u963b\u5bb3\u85ac\u306e\u4e00\u3064\u3067\u3042\u308bgefitinib\u3068\u5185\u76ae\u6210\u9577\u56e0\u5b50\u53d7\u5bb9\u4f53(EGFR)\u306e\u30ad\u30ca\u30fc\u30bc\u30c9\u30e1\u30a4\u30f3\u306e\u7acb\u4f53\u69cb\u9020\u3092\u3001\u516c\u958b\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3067\u3042\u308bPDB\u3088\u308a\u5165\u624b\u3057\uff08PDB# 3UG2)\u3001 \u305d\u306e\u69cb\u9020\u3092\u8868\u793a\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u85ac\u3067\u3042\u308bPD-1\u963b\u5bb3\u85ac\u306e\u4e00\u3064\u3067\u3042\u308bnivolumab\u306eheavy chain \u304a\u3088\u3073light chain\u306eFab\u30c9\u30e1\u30a4\u30f3\u3068\u3001\u305d\u306e\u6a19\u7684\u5206\u5b50\u3067\u3042\u308bprogrammed cell death protein-1 (PD-1) \u306e\u7acb\u4f53\u69cb\u9020\u3092\u3001PDB\u3088\u308a\u5165\u624b\u3057(PDB# 5WT9)\u3001\u305d\u306e\u69cb\u9020\u3092\u8868\u793a\u3057\u307e\u3057\u305f\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>EGFR-TKI \u00a0\u3068\u3000Nivolumab\u306e\u5206\u5b50\u306e\u7acb\u4f53\u69cb\u9020\u3092\u63b2\u8f09\u3057\u307e\u3057\u305f\u3002 EGFR-\u30c1\u30ed\u30b7\u30f3\u30ea\u30f3\u9178\u5316\u9175\u7d20\u963b\u5bb3\u85ac\u306e\u4e00\u3064\u3067\u3042\u308bgefitinib\u3068\u5185\u76ae\u6210\u9577\u56e0\u5b50\u53d7\u5bb9\u4f53(EGFR)\u306e\u30ad\u30ca\u30fc\u30bc\u30c9\u30e1\u30a4\u30f3\u306e\u7acb\u4f53\u69cb\u9020\u3092\u3001\u516c\u958b\u30c7\u30fc\u30bf\u30d9\u30fc&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[4],"tags":[],"class_list":["post-132","post","type-post","status-publish","format-standard","hentry","category-science"],"jetpack_featured_media_url":"","jetpack_shortlink":"https:\/\/wp.me\/p9b6zl-28","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/posts\/132","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=132"}],"version-history":[{"count":0,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=\/wp\/v2\/posts\/132\/revisions"}],"wp:attachment":[{"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=132"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=132"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~OIO\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=132"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}