ClinicalTrials.gov:<\/a> NCT01660126)<\/p>\n\u30bb\u30c3\u30c6\u30a3\u30f3\u30b0
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\u88ab\u9a13\u8005
\u6301\u7d9a\u6027SCH(\u7532\u72b6\u817a\u523a\u6fc0\u30db\u30eb\u30e2\u30f3TSH\u50244.60\uff0d19.9mIU\/L\u304c3\u304b\u6708\u4ee5\u4e0a\u3067\u6301\u7d9a\u3057\u3001\u904a\u96e2\u30c1\u30ed\u30ad\u30b7\u30f3FT4\u304c\u6b63\u5e38\u5024)\u3067\u5b8c\u5168\u306a\u8ee2\u5e30\u30c7\u30fc\u30bf\u306e\u3042\u308b65\u6b73\u4ee5\u4e0a\u306e\u60a3\u8005638\u4eba<\/p>\n
\u4ecb\u5165
L-\u30c1\u30ed\u30ad\u30b7\u30f3\u307e\u305f\u306f\u507d\u88c5\u306e\u7528\u91cf\u8abf\u7bc0\u3067\u30de\u30c3\u30c1\u30f3\u30b0\u3057\u305f\u30d7\u30e9\u30bb\u30dc\u670d\u7528<\/p>\n
\u6e2c\u5b9a
\u75c7\u72b6\u306b\u3088\u308b\u8ca0\u62c5\u304c\u5927\u304d\u3044\u60a3\u8005\u7fa4\uff08\u7814\u7a76\u958b\u59cb\u6642\u3067\u306e\u7532\u72b6\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u72b6\u30b9\u30b3\u30a2\uff1e30\u307e\u305f\u306f\u75b2\u52b4\u611f\u30b9\u30b3\u30a2\uff1e40\uff09\u3068\u75c7\u72b6\u306b\u3088\u308b\u8ca0\u62c5\u304c\u5c0f\u3055\u3044\u60a3\u8005\u7fa4\u3067\u3001\u7532\u72b6\u817a\u95a2\u9023QOL\u60a3\u8005\u7533\u544a\u8ee2\u5e30\u554f\u8a3a\u7968\uff08Thyroid-Related Quality-of-Life Patient-Reported Outcome Questionnaire\uff09\u306e\u7532\u72b6\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u72b6\u30b9\u30b3\u30a2\u3068\u5026\u6020\u611f\u30b9\u30b3\u30a2\uff08Hypothyroid Symptoms and Tiredness scores\uff09\uff08\u7bc4\u56f2\u30010\uff0d100\uff1b\u30b9\u30b3\u30a2\u9ad8\u5024\u3067\u3042\u308b\u307b\u3069\u75c7\u72b6\u304c\u591a\u3044\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u308b\uff09\u306e1\u5e74\u5f8c\u306e\u5909\u5316\u3092L-\u30c1\u30ed\u30ad\u30b7\u30f3\u670d\u7528\u7fa4\u3068\u30d7\u30e9\u30bb\u30dc\u670d\u7528\u7fa4\u3067\u6bd4\u8f03\u3057\u305f\u3002<\/p>\n
\u7d50\u679c
132\u4eba\u306e\u88ab\u9a13\u8005\u304c\u7532\u72b6\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u72b6\u30b9\u30b3\u30a2\uff1e30\u3001133\u4eba\u304c\u75b2\u52b4\u611f\u30b9\u30b3\u30a2\uff1e40\u3067\u3042\u3063\u305f\u3002\u75c7\u72b6\u306b\u3088\u308b\u8ca0\u62c5\u304c\u5927\u304d\u3044\u30eb\u30fc\u30d7\u3067\u306f1\u5e74\u5f8c\u306e\u7532\u72b6\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u72b6\u30b9\u30b3\u30a2\u306e\u6539\u5584\u306fL-\u30c1\u30ed\u30ad\u30b7\u30f3\u670d\u7528\u7fa4\u60a3\u8005\u7fa4\uff08\u5e73\u5747\u7fa4\u5185\u5909\u5316\u3001\uff0d12.3\uff3b95% CI, \uff0d16.6~\uff0d8.0\uff3d\uff09\u3068\u30d7\u30e9\u30bb\u30dc\u670d\u7528\u8005\u7fa4(\u5e73\u5747\u7fa4\u5185\u5909\u5316.\uff0d10.4\uff3bCI,\uff0d15.3~\uff0d5.4\uff3d)\u3067\u540c\u7a0b\u5ea6\u3067\u3042\u3063\u305f\u3002\uff1b\u8abf\u6574\u5f8c\u7fa4\u9593\u5dee\u306f\uff0d2.0\uff08CI,\uff0d5.5~1.5\uff1bP=0.27\uff09\u3067\u3042\u3063\u305f\u3002\u5026\u6020\u611f\u30b9\u30b3\u30a2\u306e\u6539\u5584\u3082L-\u30c1\u30ed\u30ad\u30b7\u30f3\u670d\u7528\u7fa4\uff08\u5e73\u5747\u7fa4\u5185\u5909\u5316\u3001\uff0d8.9\uff3bCI, \uff0d14.5~\uff0d3.3\uff3d\uff09\u3068\u30d7\u30e9\u30bb\u30dc\u670d\u7528\u7fa4\uff08\u5e73\u5747\u7fa4\u5185\u5909\u5316\u3001\uff0d10.9\uff3bCI, \uff0d16.0~\uff0d5.8\uff3d\uff09\u3067\u540c\u7a0b\u5ea6\u3067\u3042\u3063\u305f\u3002\uff1b\u8abf\u6574\u5f8c\u7fa4\u9593\u5dee\u306f0.0(CI,\uff0d4.1~4.0\uff1bP=0.99)\u3067\u3042\u3063\u305f\u3002\u7814\u7a76\u958b\u59cb\u6642\u3067\u306e\u7532\u72b6\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u72b6\u30b9\u30b3\u30a2\u3084\u5026\u6020\u611f\u30b9\u30b3\u30a2\u306b\u306fL-\u30c1\u30ed\u30ad\u30b7\u30f3\u3068\u30d7\u30e9\u30bb\u30dc\u306e\u6295\u4e0e\u306e\u6bd4\u8f03\u3067\u52b9\u679c\u304c\u78ba\u8a8d\u3067\u304d\u306a\u304b\u3063\u305f\uff08P for interaction \u306f\u7532\u72b6\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u72b6\u30b9\u30b3\u30a2\u30670.20\u3001\u5026\u6020\u611f\u30b9\u30b3\u30a2\u30670.82\uff09\u3002<\/p>\n
\u7814\u7a76\u306e\u9650\u754c
Post hoc \u89e3\u6790\u3067\u3042\u308b\u3053\u3068\u3001\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u304c\u5c0f\u3055\u3044\u3053\u3068\u30011\u5e74\u9593\u306e\u8ee2\u5e30\u30c7\u30fc\u30bf\u306e\u60a3\u8005\u3060\u3051\u306e\u691c\u8a0e\u3067\u3042\u308b\u3053\u3068<\/p>\n
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\u4e3b\u8981\u8cc7\u91d1\u63d0\u4f9b
\u3000\u30e8\u30fc\u30ed\u30c3\u30d1\u9023\u5408FP7<\/p>\n
PRC\u59d4\u54e1\u3000\u5ddd\u7530\u79c0\u4e00<\/p>\n","protected":false},"excerpt":{"rendered":"
Annals of Internal Medicine5\u67085\u65e5\u53f7\u3088\u308aOriginal Research\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002 \u6f5c\u5728\u6027\u7532\u72b6\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u3068\u7532\u72b6\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u72b6\u306e\u3042\u308b\u9ad8\u9f62\u8005\u306b\u5bfe\u3059\u308bL-\u30c1\u30ed\u30ad\u30b7\u30f3\u6cbb\u7642\uff1a\u7121\u4f5c\u70ba\u5316\u8a66\u9a13\u306e\u4e8c\u6b21\u89e3\u6790L-Thyroxine Therapy for Older Adults With Subclinical Hypothyroidism and Hypothyroid Symptoms: Secondary Analysis of a Randomized Trial https:\/\/annals.org\/\u2026\/l-thyroxine-therapy-older-adults-subcl\u2026 \u80cc\u666fL-\u30c1\u30ed\u30ad\u30b7\u30f3\u670d\u7528\u3067\u306f\u6f5c\u5728\u6027\u7532\u72b6\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\uff08SCH\uff09\u306e\u6210\u4eba\u60a3\u8005\u306e\u7532\u72b6\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u72b6\u306f\u6539\u5584\u3055\u308c\u306a\u3044\u3002\u3057\u304b\u3057\u3001\u6cbb\u7642\u524d\u306b\u75c7\u72b6\u306b\u3088\u308b\u8ca0\u62c5\u304c\u5927\u304d\u3044\u60a3\u8005\u306b\u306f\u3042\u308b\u7a0b\u5ea6\u6709\u52b9\u3060\u308d\u3046\u3002 \u76ee\u7684SCH\u3067\u75c7\u72b6\u306b\u3088\u308b\u8ca0\u62c5\u304c\u5927\u304d\u3044\u9ad8\u9f62\u8005\u3067\u306fL-\u30c1\u30ed\u30ad\u30b7\u30f3\u306b\u3088\u3063\u3066\u7532\u72b6\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u72b6\u3068\u75b2\u52b4\u611f\u304c\u6539\u5584\u3055\u308c\u308b\u304b\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068 \u7814\u7a76\u30c7\u30b6\u30a4\u30f3\u7121\u4f5c\u70ba\u5316\u30d7\u30e9\u30bb\u30dc\u6bd4\u8f03\u8a66\u9a13TRUST\uff08\u6f5c\u5728\u6027\u7532\u72b6\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u306e\u672a\u6cbb\u7642\u9ad8\u9f62\u60a3\u8005\u3067\u306e\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u88dc\u5145\u6cbb\u7642\u8a66\u9a13\uff09\u306e\u4e8c\u6b21\u89e3\u6790(ClinicalTrials.gov: NCT01660126) \u30bb\u30c3\u30c6\u30a3\u30f3\u30b0\u30b9\u30a4\u30b9\u3001\u30a2\u30a4\u30eb\u30e9\u30f3\u30c9\u3001\u30aa\u30e9\u30f3\u30c0\u3001\u30b9\u30b3\u30c3\u30c8\u30e9\u30f3\u30c9 \u88ab\u9a13\u8005\u6301\u7d9a\u6027SCH(\u7532\u72b6\u817a\u523a\u6fc0\u30db\u30eb\u30e2\u30f3TSH\u50244.60\uff0d19.9mIU\/L\u304c3\u304b\u6708\u4ee5\u4e0a\u3067\u6301\u7d9a\u3057\u3001\u904a\u96e2\u30c1\u30ed\u30ad\u30b7\u30f3FT4\u304c\u6b63\u5e38\u5024)\u3067\u5b8c\u5168\u306a\u8ee2\u5e30\u30c7\u30fc\u30bf\u306e\u3042\u308b65\u6b73\u4ee5\u4e0a\u306e\u60a3\u8005638\u4eba \u4ecb\u5165L-\u30c1\u30ed\u30ad\u30b7\u30f3\u307e\u305f\u306f\u507d\u88c5\u306e\u7528\u91cf\u8abf\u7bc0\u3067\u30de\u30c3\u30c1\u30f3\u30b0\u3057\u305f\u30d7\u30e9\u30bb\u30dc\u670d\u7528 \u6e2c\u5b9a\u75c7\u72b6\u306b\u3088\u308b\u8ca0\u62c5\u304c\u5927\u304d\u3044\u60a3\u8005\u7fa4\uff08\u7814\u7a76\u958b\u59cb\u6642\u3067\u306e\u7532\u72b6\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u72b6\u30b9\u30b3\u30a2\uff1e30\u307e\u305f\u306f\u75b2\u52b4\u611f\u30b9\u30b3\u30a2\uff1e40\uff09\u3068\u75c7\u72b6\u306b\u3088\u308b\u8ca0\u62c5\u304c\u5c0f\u3055\u3044\u60a3\u8005\u7fa4\u3067\u3001\u7532\u72b6\u817a\u95a2\u9023QOL\u60a3\u8005\u7533\u544a\u8ee2\u5e30\u554f\u8a3a\u7968\uff08Thyroid-Related Quality-of-Life Patient-Reported Outcome Questionnaire\uff09\u306e\u7532\u72b6\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u72b6\u30b9\u30b3\u30a2\u3068\u5026\u6020\u611f\u30b9\u30b3\u30a2\uff08Hypothyroid Symptoms and Tiredness scores\uff09\uff08\u7bc4\u56f2\u30010\uff0d100\uff1b\u30b9\u30b3\u30a2\u9ad8\u5024\u3067\u3042\u308b\u307b\u3069\u75c7\u72b6\u304c\u591a\u3044\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u308b\uff09\u306e1\u5e74\u5f8c\u306e\u5909\u5316\u3092L-\u30c1\u30ed\u30ad\u30b7\u30f3\u670d\u7528\u7fa4\u3068\u30d7\u30e9\u30bb\u30dc\u670d\u7528\u7fa4\u3067\u6bd4\u8f03\u3057\u305f\u3002 \u7d50\u679c132\u4eba\u306e\u88ab\u9a13\u8005\u304c\u7532\u72b6\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u72b6\u30b9\u30b3\u30a2\uff1e30\u3001133\u4eba\u304c\u75b2\u52b4\u611f\u30b9\u30b3\u30a2\uff1e40\u3067\u3042\u3063\u305f\u3002\u75c7\u72b6\u306b\u3088\u308b\u8ca0\u62c5\u304c\u5927\u304d\u3044\u30eb\u30fc\u30d7\u3067\u306f1\u5e74\u5f8c\u306e\u7532\u72b6\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u72b6\u30b9\u30b3\u30a2\u306e\u6539\u5584\u306fL-\u30c1\u30ed\u30ad\u30b7\u30f3\u670d\u7528\u7fa4\u60a3\u8005\u7fa4\uff08\u5e73\u5747\u7fa4\u5185\u5909\u5316\u3001\uff0d12.3\uff3b95% CI, \uff0d16.6~\uff0d8.0\uff3d\uff09\u3068\u30d7\u30e9\u30bb\u30dc\u670d\u7528\u8005\u7fa4(\u5e73\u5747\u7fa4\u5185\u5909\u5316.\uff0d10.4\uff3bCI,\uff0d15.3~\uff0d5.4\uff3d)\u3067\u540c\u7a0b\u5ea6\u3067\u3042\u3063\u305f\u3002\uff1b\u8abf\u6574\u5f8c\u7fa4\u9593\u5dee\u306f\uff0d2.0\uff08CI,\uff0d5.5~1.5\uff1bP=0.27\uff09\u3067\u3042\u3063\u305f\u3002\u5026\u6020\u611f\u30b9\u30b3\u30a2\u306e\u6539\u5584\u3082L-\u30c1\u30ed\u30ad\u30b7\u30f3\u670d\u7528\u7fa4\uff08\u5e73\u5747\u7fa4\u5185\u5909\u5316\u3001\uff0d8.9\uff3bCI, \uff0d14.5~\uff0d3.3\uff3d\uff09\u3068\u30d7\u30e9\u30bb\u30dc\u670d\u7528\u7fa4\uff08\u5e73\u5747\u7fa4\u5185\u5909\u5316\u3001\uff0d10.9\uff3bCI, \uff0d16.0~\uff0d5.8\uff3d\uff09\u3067\u540c\u7a0b\u5ea6\u3067\u3042\u3063\u305f\u3002\uff1b\u8abf\u6574\u5f8c\u7fa4\u9593\u5dee\u306f0.0(CI,\uff0d4.1~4.0\uff1bP=0.99)\u3067\u3042\u3063\u305f\u3002\u7814\u7a76\u958b\u59cb\u6642\u3067\u306e\u7532\u72b6\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u72b6\u30b9\u30b3\u30a2\u3084\u5026\u6020\u611f\u30b9\u30b3\u30a2\u306b\u306fL-\u30c1\u30ed\u30ad\u30b7\u30f3\u3068\u30d7\u30e9\u30bb\u30dc\u306e\u6295\u4e0e\u306e\u6bd4\u8f03\u3067\u52b9\u679c\u304c\u78ba\u8a8d\u3067\u304d\u306a\u304b\u3063\u305f\uff08P for interaction \u306f\u7532\u72b6\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u72b6\u30b9\u30b3\u30a2\u30670.20\u3001\u5026\u6020\u611f\u30b9\u30b3\u30a2\u30670.82\uff09\u3002 \u7814\u7a76\u306e\u9650\u754cPost hoc \u89e3\u6790\u3067\u3042\u308b\u3053\u3068\u3001\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u304c\u5c0f\u3055\u3044\u3053\u3068\u30011\u5e74\u9593\u306e\u8ee2\u5e30\u30c7\u30fc\u30bf\u306e\u60a3\u8005\u3060\u3051\u306e\u691c\u8a0e\u3067\u3042\u308b\u3053\u3068 \u7d50\u8ad6\u7814\u7a76\u958b\u59cb\u6642\u306bSCH\u3067\u75c7\u72b6\u306b\u3088\u308b\u8ca0\u62c5\u304c\u5927\u304d\u3044\u9ad8\u9f62\u8005\u3067\u306f\u3001\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u3066L-\u30c1\u30ed\u30ad\u30b7\u30f3\u306b\u3088\u3063\u3066\u7532\u72b6\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u72b6\u3084\u5026\u6020\u611f\u306f\u6539\u5584\u3055\u308c\u306a\u304b\u3063\u305f\u3002 \u4e3b\u8981\u8cc7\u91d1\u63d0\u4f9b\u3000\u30e8\u30fc\u30ed\u30c3\u30d1\u9023\u5408FP7 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