{"id":2715,"date":"2020-05-13T10:45:47","date_gmt":"2020-05-13T01:45:47","guid":{"rendered":"https:\/\/plaza.umin.ac.jp\/~ACP\/?p=2715"},"modified":"2020-05-13T11:18:10","modified_gmt":"2020-05-13T02:18:10","slug":"acp-diabetes-monthly-2%e6%9c%8814%e6%97%a5%e5%8f%b7%e3%82%88%e3%82%8asglt-2%e9%98%bb%e5%ae%b3%e8%96%ac%e3%81%ae%e5%bf%83%e8%a1%80%e7%ae%a1%e3%82%a2%e3%82%a6%e3%83%88%e3%82%ab%e3%83%a0%e3%81%ab","status":"publish","type":"post","link":"https:\/\/plaza.umin.ac.jp\/~ACP\/2020\/05\/13\/acp-diabetes-monthly-2%e6%9c%8814%e6%97%a5%e5%8f%b7%e3%82%88%e3%82%8asglt-2%e9%98%bb%e5%ae%b3%e8%96%ac%e3%81%ae%e5%bf%83%e8%a1%80%e7%ae%a1%e3%82%a2%e3%82%a6%e3%83%88%e3%82%ab%e3%83%a0%e3%81%ab.html","title":{"rendered":"ACP diabetes monthly 2\u670814\u65e5\u53f7\u3088\u308aSGLT-2\u963b\u5bb3\u85ac\u306e\u5fc3\u8840\u7ba1\u30a2\u30a6\u30c8\u30ab\u30e0\u306b\u5bfe\u3059\u308b \u30ec\u30d3\u30e5\u30fc\u8a18\u4e8b\u3092\u7d39\u4ecb"},"content":{"rendered":"

ACP diabetes monthly\u30002\u670814\u65e5\u53f7\u3088\u308aSGLT-2\u963b\u5bb3\u85ac\u306e\u5fc3\u8840\u7ba1\u30a2\u30a6\u30c8\u30ab\u30e0\u306b\u5bfe\u3059\u308b \u30ec\u30d3\u30e5\u30fc\u8a18\u4e8b\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002
SGLT-2 inhibitors reduced risk of cardiovascular disease, death, review finds<\/p>\n

\u3000\u3000\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\/\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306e\u8457\u8005\u306f\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u3042\u308b\u60a3\u8005\u306b\u5bfe\u3057SGLT-\uff12\u963b\u5bb3\u85ac\u306e\u4f7f\u7528\u3092\u5897\u3084\u3059\u305f\u3081\u306b\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306e\u518d\u8003\u3092\u63a8\u5968\u3057\u305f\u3002\u3000
\u3000\u3000\u6700\u8fd1\u306e\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\u306b\u3088\u308b\u3068SGLT-2\u963b\u5bb3\u85ac\u306f\u60a3\u8005\u304c\u5fc3\u8840\u7ba1\u75be\u60a3\u307e\u305f\u306f\u814e\u75be\u60a3\u306e\u65e2\u5f80\u3092\u6709\u3057\u3066\u3044\u305f\u304b\u3069\u3046\u304b\u306b\u304b\u304b\u308f\u3089\u305a\u3001\u7cd6\u5c3f\u75c5\u60a3\u8005\u306e\u5fc3\u8840\u7ba1\u75be\u60a3\u304a\u3088\u3073\u6b7b\u4ea1\u30ea\u30b9\u30af\u3092\u4f4e\u4e0b\u3055\u305b\u305f\u3002
\u7814\u7a76\u8005\u9054\u306f\u7cd6\u5c3f\u75c5\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3001\u30d7\u30e9\u30bb\u30dc\u3068SGLT-2\u963b\u5bb3\u85ac\u3092\u6bd4\u8f03\u3057\u305f\uff14\u3064\u306e\u5927\u898f\u6a21\u7814\u7a76\u306e\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\/\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3092\u884c\u3063\u305f\u3002\uff14\u3064\u306e\u7814\u7a76\u3067\u306f\u5168\u6bcd\u96c6\u56e3\u304a\u3088\u3073\u7814\u7a76\u958b\u59cb\u6642\u306b\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u3001\u814e\u6a5f\u80fd\u4f4e\u4e0b\u3001\u5fc3\u4e0d\u5168\u306e\u3044\u305a\u308c\u304b\u3092\u65e2\u5f80\u3068\u3057\u3066\u6709\u3057\u3066\u3044\u305f\u60a3\u8005\u306e\u5404\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u3067\u5fc3\u8840\u7ba1\u30a2\u30a6\u30c8\u30ab\u30e0\u306b\u5bfe\u3059\u308b\u52b9\u679c\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002\u7d50\u679c\u306f1\u670829\u65e5\u53f7\u306eJournal of the American Heart Association\u306b\u516c\u958b\u3055\u308c\u3066\u3044\u308b\u3002
\u8ffd\u8de1\u671f\u9593\u4e2d\u592e\u5024\u306f2.9\u5e74\u306738723\u4eba\u306e\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u3066\u3044\u308b\u3002\u300022870\u4eba(59%)\u306b\u5fc3\u8840\u7ba1\u75be\u60a3\u30017754\u4eba(20%)\u306b\u814e\u6a5f\u80fd\u969c\u5bb3\u30014523\u4eba(12%)\u306b\u5fc3\u4e0d\u5168\u3092\u305d\u308c\u305e\u308c\u65e2\u5f80\u3068\u3057\u3066\u6709\u3057\u3066\u3044\u305f\u3002\u5bfe\u8c61\u3068\u306a\u3063\u305f4\u7814\u7a76\u3067\u306f\u5408\u8a08\u30673823\u56de\u306e\u4e3b\u8981\u306a\u5fc3\u81d3\u30a4\u30d9\u30f3\u30c8\u30011192\u56de\u306e\u5fc3\u4e0d\u5168\u5165\u9662\u30011506\u4eba\u306b\u5fc3\u8840\u7ba1\u6b7b\u53ca\u3073\u30012612\u4eba\u306b\u5168\u539f\u56e0\u6b7b\u4ea1\u304c\u305d\u308c\u305e\u308c\u767a\u751f\u3057\u305f\u3002\u5168\u4f53\u7684\u52b9\u679c\u306e\u691c\u8a0e\u3067\u306fSGLT-2\u963b\u5bb3\u85ac\u306f\u30af\u30e9\u30b9\u52b9\u679c\u3068\u3057\u3066\u4e3b\u8981\u306a\u5fc3\u81d3\u30a4\u30d9\u30f3\u30c8\u306e\u6709\u610f\u306a\u6e1b\u5c11\u3092\u8a8d\u3081\u305f(\u30cf\u30b6\u30fc\u30c9\u6bd40.88 95% CI 0.82-0.94 P<0.001)\u3002\u3000SGLT-2\u963b\u5bb3\u85ac\u3067\u89b3\u5bdf\u3055\u308c\u305f\u6709\u7528\u6027\u304c\u3001\u6cbb\u9a13\u53c2\u52a0\u6642\u306b\u57fa\u790e\u75be\u60a3\u3068\u3057\u3066\u5b58\u5728\u3059\u308b\u5fc3\u8840\u7ba1\u75be\u60a3\u3001\u5fc3\u4e0d\u5168\u306b\u3088\u3063\u3066\u5b9a\u7fa9\u3065\u3051\u3089\u308c\u308b\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u306b\u3088\u3063\u3066\u7570\u306a\u308b\u3068\u3044\u3046\u3053\u3068\u306f\u306a\u304b\u3063\u305f\u3002(\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u3067\u306e\u7570\u8cea\u6027\u8a55\u4fa1\uff1aP>0.252 I2\u691c\u5b9a\uff1c25%)
\u3000\u3000\u3069\u306e\u60a3\u8005\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7(\u5fc3\u8840\u7ba1\u75be\u60a3\u3000\u814e\u6a5f\u80fd\u4f4e\u4e0b\u3000\u5fc3\u4e0d\u5168)\u3082\u300c\u5fc3\u4e0d\u5168\u306b\u3088\u308b\u5165\u9662\u300d(\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u7570\u8cea\u6027\u3000P>0.302 I2<10%)\u300c\u5fc3\u8840\u7ba1\u6b7b\u300d(\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u7570\u8cea\u6027\u3000P>0.167 I2<50%)\u300c\u5168\u539f\u56e0\u6b7b\u4ea1\u300d(\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u7570\u8cea\u6027\u3000P>0.354 I2=0%)\u3068\u3044\u3046\u30a2\u30a6\u30c8\u30ab\u30e0\u306bSGLT-2\u6295\u4e0e\u7fa4\u3067\u6709\u7528\u6027\u304c\u898b\u3089\u308c\u305f\u3002\u3053\u306e\u7814\u7a76\u3067\u306f\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u9593\u3067\u52b9\u679c\u306b\uff11\u3064\u9055\u3044\u304c\u660e\u3089\u304b\u306b\u3055\u308c\u305f\u3002SGLT-2\u963b\u5bb3\u85ac\u306f\u814e\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u305f\u60a3\u8005\u3067\u306f\u8133\u5352\u4e2d\u306e\u30ea\u30b9\u30af\u304c\u4f4e\u4e0b\u3057\u305f\u304c\u3001\u814e\u6a5f\u80fd\u304c\u4fdd\u305f\u308c\u3066\u3044\u308b\u60a3\u8005\u3067\u306f\u8133\u5352\u4e2d\u306e\u30ea\u30b9\u30af\u4f4e\u4e0b\u3092\u8a8d\u3081\u306a\u304b\u3063\u305f\u3002(\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u7570\u8cea\u6027\u3000P=0.020 I2=81%)
\u3000\u201c\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u9593\u3067\u306e\u7814\u7a76\u7d50\u679c\u306e\u5e83\u7bc4\u306a\u4e00\u81f4\u304b\u3089\u3001\u30af\u30e9\u30b9\u5168\u4f53\u3068\u3057\u3066SGLT-2\u963b\u5bb3\u85ac\u306e\u5e45\u5e83\u3044\u81e8\u5e8a\u4f7f\u7528\u304c\u63d0\u6848\u3055\u308c\u308b\u3002\u201c\u3068\u8457\u8005\u3089\u306f\u8a18\u8f09\u3057\u3066\u3044\u308b\u3002\u5f7c\u3089\u306f\u69d8\u3005\u306a\u80cc\u666f\u3092\u6301\u3063\u305f\uff12\u578b\u7cd6\u5c3f\u75c5\u306e\u60a3\u8005\u304c\u3053\u306e\u30af\u30e9\u30b9\u306e\u85ac\u5264\u306e\u6069\u6075\u3092\u53d7\u3051\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3068\u8ff0\u3079\u3066\u3044\u308b\u3002\u201d\u6211\u3005\u306e\u7d50\u679c\u306f\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u65e2\u5f80\u306e\u6709\u7121\u306b\u304b\u304b\u308f\u3089\u305aSGLT-2\u963b\u5bb3\u85ac\u6295\u4e0e\u306e\u63a8\u5968\u306b\u95a2\u3057\u3066\u73fe\u884c\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u518d\u8a55\u4fa1\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002\u201c\u3000\u3068\u8a18\u8f09\u3055\u308c\u3066\u3044\u308b\u3002\u8457\u8005\u3089\u306f\u57fa\u790e\u75be\u60a3\u3068\u3057\u3066\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u306a\u3044\u60a3\u8005\u306e\u30a4\u30d9\u30f3\u30c8\u767a\u751f\u7387\u304c\u4f4e\u3044\u3053\u3068\u304c\u305d\u306e\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u3067\u7d71\u8a08\u691c\u51fa\u529b\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u3092\u8b66\u544a\u3057\u3066\u3044\u308b\u3002
\u6ce8)
I2\u7d71\u8a08\uff1a\u5076\u7136\u3092\u8d85\u3048\u305f\u4e0d\u5747\u4e00\u6027\u306e\u5909\u52d5\u7387
0-25% \u4e0d\u5747\u4e00\u6027\u306f\u4f4e\u3044\u53ef\u80fd\u6027
26-75%\u3000\u4e0d\u5747\u4e00\u6027\u306f\u4e2d\u7b49\u5ea6\u306e\u53ef\u80fd\u6027
76-100% \u4e0d\u5747\u4e00\u6027\u306f\u9ad8\u5ea6\u306e\u53ef\u80fd\u6027
\u7570\u8cea\u6027\u8a55\u4fa1\u306b\u304a\u3051\u308bP\u5024<0.05\u306f\u5076\u7136\u3092\u8d85\u3048\u3066\u7570\u8cea\u6027\u304c\u9ad8\u3044\u53ef\u80fd\u6027\u304c\u3042\u308b<\/p>\n

PRC\u3000\u897f\u6751\u3000\u5149\u6ecb
\uff03SGLT<\/a>-2\u963b\u5bb3\u85ac\u3000\uff03\u5fc3\u8840\u7ba1\u30a2\u30a6\u30c8\u30ab\u30e0\u30ea\u30b9\u30af\u4f4e\u4e0b<\/a> \uff03\u6b7b\u4ea1\u30ea\u30b9\u30af\u4f4e\u4e0b<\/a>
\u5143\u306b\u306a\u3063\u305f\u8ad6\u6587\u306f\u4e0b\u8a18\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002
PMID: 31992158
https:\/\/diabetes.acponline.org\/archives\/2020\/02\/14\/3.htm\u2026<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

ACP diabetes monthly\u30002\u670814\u65e5\u53f7\u3088\u308aSGLT-2\u963b\u5bb3\u85ac\u306e\u5fc3\u8840\u7ba1\u30a2\u30a6\u30c8\u30ab\u30e0\u306b\u5bfe\u3059\u308b \u30ec\u30d3\u30e5\u30fc\u8a18\u4e8b\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002SGLT-2 inhibitors reduced risk of cardiovascular disease, death, review finds 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of the American Heart 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