{"id":2713,"date":"2020-05-13T10:44:37","date_gmt":"2020-05-13T01:44:37","guid":{"rendered":"https:\/\/plaza.umin.ac.jp\/~ACP\/?p=2713"},"modified":"2020-05-13T11:17:52","modified_gmt":"2020-05-13T02:17:52","slug":"internist-weekly%e3%81%8b%e3%82%89%e3%81%ae%e8%a8%98%e4%ba%8b%e3%82%92%e7%b4%b9%e4%bb%8b","status":"publish","type":"post","link":"https:\/\/plaza.umin.ac.jp\/~ACP\/2020\/05\/13\/internist-weekly%e3%81%8b%e3%82%89%e3%81%ae%e8%a8%98%e4%ba%8b%e3%82%92%e7%b4%b9%e4%bb%8b.html","title":{"rendered":"Internist Weekly\u304b\u3089\u306e\u8a18\u4e8b\u3092\u7d39\u4ecb"},"content":{"rendered":"

Internist Weekly\u304b\u3089\u306e\u8a18\u4e8b\u3092\u7d39\u4ecb\u81f4\u3057\u307e\u3059\u3002<\/p>\n

Antivirals plus antibiotics may lower risk of hospitalization in some patients with influenza<\/p>\n

\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u7f79\u60a3\u6642\u306e\u6297\u30a6\u30a4\u30eb\u30b9\u7642\u6cd5\u306b\u6297\u83cc\u85ac\u3092\u4f75\u7528\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u5165\u9662\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3067\u304d\u308b\u304b\u3082\u3057\u308c\u306a\u3044<\/p>\n

\u3053\u306e\u7814\u7a76\u3067\u306f\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u5358\u72ec\u7642\u6cd5\u3068\u6bd4\u8f03\u3057\u3066\u3001\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u30fb\u6297\u83cc\u85ac\u4f75\u7528\u7642\u6cd5\u3067\u306f30\u65e5\u4ee5\u5185\u306e\u547c\u5438\u5668\u75be\u60a3\u304c\u539f\u56e0\u306e\u5165\u9662\u30ea\u30b9\u30af\u304c\u6709\u610f\u306b\u6e1b\u5c11\u3057\u305f\uff08\u8a3b1\uff09\u304c\u3001\u3053\u306e\u3053\u3068\u306f\u4f75\u7528\u7642\u6cd5\u304c\u4e00\u822c\u7684\u306b\u7528\u3044\u3089\u308c\u308b\u3079\u304d\u3067\u3042\u308b\u3053\u3068\u3092\u610f\u5473\u3059\u308b\u8a33\u3067\u306f\u306a\u3044\u3001\u3068\u8457\u8005\u306f\u8ff0\u3079\u305f\u3002<\/p>\n

\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u306b\u7f79\u60a3\u3057\u305f\u7c73\u56fd\u9000\u5f79\u8ecd\u4eba\u3067\u306f\u3001\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u30fb\u6297\u83cc\u85ac\u4f75\u7528\u7642\u6cd5\u306b\u3088\u308a\u539f\u56e0\u3092\u554f\u308f\u306a\u3044\u5165\u9662\u30fb\u547c\u5438\u5668\u75be\u60a3\u3067\u306e\u5165\u9662\u304c\u6e1b\u5c11\u3057\u305f\u3053\u3068\u304c\u6700\u8fd1\u306e\u5f8c\u308d\u5411\u304d\u7814\u7a76\u3067\u793a\u3055\u308c\u305f\u3002<\/p>\n

\u7814\u7a76\u8005\u306fVeterans Affairs Informatics and Computing Infrastructure (VINCI\uff1a\u9000\u5f79\u8ecd\u4eba\u306e\u5065\u5eb7\u7ba1\u7406\u30c7\u30fc\u30bf\u60c5\u5831)\u3092\u5229\u7528\u3057\u30012011\u5e741\u6708\u304b\u30892019\u5e741\u6708\u306e\u9593\u306b\u691c\u67fb\u3067\u78ba\u5b9a\u3057\u305f\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u60a3\u8005\u306e\u81e8\u5e8a\u7d4c\u904e\u306b\u6ce8\u76ee\u3057\u305f\u3002<\/p>\n

\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u8a3a\u65ad\u304b\u308930\u65e5\u4ee5\u5185\u306b\u3001\u539f\u56e0\u3092\u554f\u308f\u306a\u3044\u5165\u9662\u3068\u547c\u5438\u5668\u75be\u60a3\u3067\u306e\u5165\u9662\u3092\u3001\u7121\u6295\u85ac\u7fa4\u3001\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u5358\u72ec\u7fa4\u3001\u6297\u83cc\u85ac\u5358\u72ec\u7fa4\u3001\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u30fb\u6297\u83cc\u85ac\u4f75\u7528\u7fa4\u306e\u9593\u3067\u6bd4\u8f03\u3057\u305f\u3002\u30d7\u30e9\u30a4\u30de\u30ea\u30b1\u30a2\u65bd\u8a2d\u3082\u3057\u304f\u306f\u75c5\u9662\u6551\u6025\u5916\u6765\u3092\u8a2a\u308c\u3066\u8a3a\u65ad\u3055\u308c\u305f\u8005\u3001\u6551\u6025\u5916\u6765\u306b\u642c\u9001\u3055\u308c\u305f\u8005\u306f\u9664\u5916\u3001\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u8a3a\u65ad\u306e30\u65e5\u524d\u307e\u3067\u306b\u5165\u9662\u6b74\u304c\u306a\u3044\u8005\u3001\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u8a3a\u65ad\u5f53\u65e5\u306b\u5165\u9662\u3068\u306a\u3063\u305f\u8005\u306f\u9664\u5916\u3001\u53d7\u8a3a\u6642\u304b\u3089\u306evital sign\u306e\u30c7\u30fc\u30bf\u304c\u3042\u308b\u8005\u3092\u5bfe\u8c61\u8005\u3068\u3057\u305f\u3002\u7d50\u679c\u306f\u30aa\u30f3\u30e9\u30a4\u30f3\u72481\u670824\u65e5\u4ed8\u3000Clinical Infectious Disease\u306b\u63b2\u8f09\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n

\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u3068\u8a3a\u65ad\u3055\u308c\u305f12806\u4eba\u306e\u5bfe\u8c61\u8005\u306e\u5185\u30014228\u306f\u7121\u6295\u85ac\u7fa4\u30016492\u4eba\u306f\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u5358\u72ec\u3001671\u4eba\u306f\u6297\u83cc\u85ac\u5358\u72ec\u30011415\u4eba\u306f\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u30fb\u6297\u83cc\u85ac\u3092\u51e6\u65b9\u3055\u308c\u305f\u3002\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u306e\u8a3a\u65ad\u306e\u5927\u90e8\u5206\u306f\u75c5\u9662\u6551\u6025\u5916\u6765\u3067\u884c\u308f\u308c\u305f\u3002\u6297\u83cc\u85ac\u3067\u6295\u4e0e\u983b\u5ea6\u304c\u9ad8\u304b\u3063\u305f\u3082\u306e\u306f\u30de\u30af\u30ed\u30e9\u30a4\u30c9\u3001\u30da\u30cb\u30b7\u30ea\u30f3\u3001\u30ad\u30ce\u30ed\u30f3\u7cfb\u3001\u30c6\u30c8\u30e9\u30b5\u30a4\u30af\u30ea\u30f3\u3067\u3042\u3063\u305f\u3002\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u306f\u30aa\u30bb\u30eb\u30bf\u30df\u30d3\u30eb\u304c\u7b46\u982d\u306799.9%\u3092\u5360\u3081\u305f\u3002\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u3068\u6297\u83cc\u85ac\u3092\u51e6\u65b9\u3055\u308c\u305f\u7fa4\u306f\u30c1\u30e3\u30fc\u30eb\u30bd\u30f3\u4f75\u5b58\u75be\u60a3\u6307\u6570(Charlson Comorbidity Index)\u304c\u6700\u3082\u9ad8\u304f(1.62)\u3001\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u7fa4\u306f\u6700\u3082\u4f4e\u304b\u3063\u305f(1.35)\u3002<\/p>\n

\u539f\u56e0\u3092\u554f\u308f\u306a\u3044\u5165\u9662\u306e\u5272\u5408\u306f\u3001\u7121\u6295\u85ac\u7fa4\u3067\u6700\u3082\u9ad8\u304f(10.48%)\u3001\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u30fb\u6297\u83cc\u85ac\u4f75\u7528\u7fa4\u3067\u6700\u3082\u4f4e\u304b\u3063\u305f(3.18%)\u3002\u547c\u5438\u5668\u75be\u60a3\u304c\u539f\u56e0\u306e\u5165\u9662\u3067\u3082\u540c\u3058\u50be\u5411\u304c\u307f\u3089\u308c\u3001\u7121\u6295\u85ac\u7fa4\u3067\u6700\u9ad8\u3068\u306a\u308a(6.58%)\u3001\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u30fb\u6297\u83cc\u85ac\u4f75\u7528\u7fa4\u3067\u6700\u4f4e\u3067\u3042\u3063\u305f(1.06%)\u3002\u8a3a\u65ad\u304b\u308930\u65e5\u4ee5\u5185\u3067\u306e\u539f\u56e0\u3092\u554f\u308f\u306a\u3044\u5165\u9662\u306e\u30ea\u30b9\u30af\u306f\u7121\u6295\u85ac\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u3001\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u7fa4\u3067\u306f63%(\u76f8\u5bfe\u5371\u967a\u5ea6RR 0.37\uff1a95%CI 0.32\uff0d0.44)\u3001\u6297\u83cc\u85ac\u5358\u72ec\u7fa4\u3067\u306f57%(RR 0.43 : 95%CI 0.31-0.62)\u3001\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u30fb\u6297\u83cc\u85ac\u4f75\u7528\u7fa4\u3067\u306f72%\u4f4e\u304b\u3063\u305f(RR 0.28:95%CI 0.21-0.38)\u3002\u6cbb\u7642\u85ac\u306e\u6295\u4e0e\u306f\u3001\u6700\u521d\u306e5\u65e5\u9593\u3067\u6700\u3082\u9ad8\u3044\u5165\u9662\u963b\u6b62\u52b9\u679c\u3092\u793a\u3057\u305f\u3002<\/p>\n

\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u30fb\u6297\u83cc\u85ac\u4f75\u7528\u7fa4\u3067\u306f\u3001\u539f\u56e0\u3092\u554f\u308f\u306a\u3044\u5165\u9662\u306e\u30ea\u30b9\u30af\u304c\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u5358\u72ec\u7fa4\u3088\u308a\u3082\u4f4e\u3044\u50be\u5411\u306b\u3042\u3063\u305f\u304c\u3001CI\u306f\u5404\u7d4c\u904e\u671f\u9593\u30671\u3092\u307e\u305f\u3044\u3067\u3044\u305f(\u8abf\u6574\u76f8\u5bfe\u5371\u967a\u5ea6\uff1a\u8a3a\u65ad\u5f8c1\uff0d5\u65e50.67 (95%CI 0.41\uff0d1.11)\u3001\u8a3a\u65ad\u5f8c1\uff0d10\u65e50.67 (95%CI 0.44-1.01)\u3001\u8a3a\u65ad\u5f8c1\uff0d30\u65e50.73 (95%CI0.53\uff0d1.01))\u3002\u547c\u5438\u5668\u75be\u60a3\u306b\u3088\u308b\u5165\u9662\u3067\u3082\u540c\u69d8\u306e\u50be\u5411\u306b\u3042\u3063\u305f\u304c\u3001\u7570\u306a\u308b\u70b9\u306f\u3001\u8a3a\u65ad\u5f8c30\u65e5\u306e\u6642\u70b9\u3067\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u30fb\u6297\u83cc\u85ac\u4f75\u7528\u7fa4\u3067\u306f\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u5358\u72ec\u7fa4\u306b\u5bfe\u3057\u3066\u6709\u610f\u5dee\u3092\u3082\u3063\u3066\u30ea\u30b9\u30af\u304c\u4f4e\u304f\u306a\u3063\u305f(\u8abf\u6574\u76f8\u5bfe\u5371\u967a\u5ea60.53 (95%CI 0.31- 0.94))\u3002\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u89e3\u6790\u3067\u306f65\u6b73\u4ee5\u4e0a\u306e\u6162\u6027\u547c\u5438\u5668\u75be\u60a3\u3092\u6709\u3059\u308b\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u30fb\u6297\u83cc\u85ac\u4f75\u7528\u7fa4\u3067\u306f\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u5358\u72ec\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u547c\u5438\u5668\u75be\u60a3\u306b\u3088\u308b\u5165\u9662\u30ea\u30b9\u30af\u304c\u4f4e\u304f\u306a\u3063\u3066\u3044\u305f\u3002<\/p>\n

\u7814\u7a76\u306e\u9650\u754c\u304c\u8907\u6570\u3042\u308b\u4e2d\u3067\u7279\u306b\u8457\u8005\u304c\u8a00\u53ca\u3057\u305f\u70b9\u306f\u3001\u89b3\u5bdf\u7814\u7a76\u3067\u3042\u308b\u3053\u3068\u3001\u4fdd\u967a\u8acb\u6c42\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306b\u57fa\u3065\u3044\u3066\u3044\u308b\u3053\u3068\u3067\u3042\u3063\u305f(\u8a3b\uff12)\u3002\u307e\u305f\u7814\u7a76\u5bfe\u8c61\u8005\u304c\u4e3b\u306b\u767d\u4eba\u3001\u7537\u6027\u3001\u5e73\u5747\u5e74\u9f62\u304c57\u6b73\u304b\u308960\u6b73\u3067\u3042\u308a\u3001\u7d50\u679c\u306f\u4ed6\u306e\u80cc\u666f\u3092\u6301\u3064\u60a3\u8005\u306b\u307e\u3067\u4e00\u822c\u5316\u3059\u308b\u3082\u306e\u3067\u306f\u306a\u3044\u3068\u3082\u8457\u8005\u306f\u8ff0\u3079\u3066\u3044\u308b\u3002\u7814\u7a76\u306e\u7d50\u679c\u3092\u8e0f\u307e\u3048\u308b\u3068\u3001\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u3068\u6297\u83cc\u85ac\u306e\u4f75\u7528\u306f\u3001\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u304c\u78ba\u5b9a\u3057\u305f\u60a3\u8005\u306e\u5185\u3067\u4e00\u5b9a\u6761\u4ef6\u3092\u6e80\u305f\u3057\u305f\u60a3\u8005\u306b\u306f\u5f79\u7acb\u3064\u304b\u3082\u3057\u308c\u306a\u3044\u3068\u8457\u8005\u306f\u7d50\u8ad6\u3057\u3066\u3044\u308b\u3002\u4e00\u65b9\u3067\u3001\u300c\u4f75\u7528\u7642\u6cd5\u3092\u753b\u4e00\u7684\u306b\u7528\u3044\u308b\u3053\u3068\u306f\u63a8\u5968\u3057\u306a\u3044\u3057\u3001\u4eca\u56de\u306e\u7d50\u679c\u304c\u73fe\u6642\u70b9\u3067\u306e\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u8a3a\u7642\u306b\u5909\u5316\u3092\u3082\u305f\u3089\u3059\u3082\u306e\u3068\u3082\u8003\u3048\u3066\u3044\u306a\u3044\u300d\u3068\u8ad6\u6587\u306b\u8a18\u8f09\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n

\u8a3b\uff11\uff1a\u7d39\u4ecb\u8a18\u4e8b\u3067\u306f\u3001\u300c\u95a2\u9023\u3092\u8a8d\u3081\u305f\u300d\u3068\u8a18\u8f09\u3055\u308c\u3066\u3044\u307e\u3059\u3002
\u672c\u7814\u7a76\u306f\u89b3\u5bdf\u7814\u7a76\u3067\u3042\u308a\u3001\u8a55\u4fa1\u9805\u76ee\u3068outcome\u306b\u7d71\u8a08\u7684\u95a2\u9023\u3092\u8a8d\u3081\u305f\u3001\u3057\u304b\u3057\u3001
\u7814\u7a76\u306e\u6027\u8cea\u4e0a\u56e0\u679c\u95a2\u4fc2\u306f\u8a55\u4fa1\u3067\u304d\u306a\u3044\u3068\u306e\u610f\u5473\u5408\u3044\u304c\u8fbc\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002PRC\u59d4\u54e1\u4f1aB\u30b0\u30eb\u30fc\u30d7\u5185\u3067\u8a0e\u8ad6\u3057\u305f\u7d50\u679c\u3001\u7ffb\u8a33\u3067\u306f\u5185\u5bb9\u7406\u89e3\u3092\u512a\u5148\u3057\u305f\u8868\u73fe\u3068\u3057\u307e\u3057\u305f\u3002
\u8a3b\uff12\uff1a\u60a3\u8005\u306e\u4f75\u5b58\u75c7\u3001\u305d\u306e\u5f8c\u306e\u75be\u60a3\u767a\u75c7\u30fb\u5165\u9662\u3001\u51e6\u65b9\u5185\u5bb9\u306f\u4fdd\u967a\u8acb\u6c42\u30c7\u30fc\u30bf\u304b\u3089\u62bd\u51fa<\/p>\n

\u5143\u306b\u306a\u3063\u305f\u8ad6\u6587\u306f\u4e0b\u8a18\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002
Clin Infect Dis. 2020 Jan 24. pii: ciaa074. doi: 10.1093\/cid\/ciaa074. [Epub ahead of print]
https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31974543<\/a><\/p>\n

https:\/\/acpinternist.org\/weekly\/archives\/2020\/02\/04\/2.htm<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Internist Weekly\u304b\u3089\u306e\u8a18\u4e8b\u3092\u7d39\u4ecb\u81f4\u3057\u307e\u3059\u3002 Antivirals plus antibiotics may lower risk of hospitalization in some patients with influenza \u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u7f79\u60a3\u6642\u306e\u6297\u30a6\u30a4\u30eb\u30b9\u7642\u6cd5\u306b\u6297\u83cc\u85ac\u3092\u4f75\u7528\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u5165\u9662\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3067\u304d\u308b\u304b\u3082\u3057\u308c\u306a\u3044 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sign\u306e\u30c7\u30fc\u30bf\u304c\u3042\u308b\u8005\u3092\u5bfe\u8c61\u8005\u3068\u3057\u305f\u3002\u7d50\u679c\u306f\u30aa\u30f3\u30e9\u30a4\u30f3\u72481\u670824\u65e5\u4ed8\u3000Clinical Infectious Disease\u306b\u63b2\u8f09\u3055\u308c\u3066\u3044\u308b\u3002 \u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u3068\u8a3a\u65ad\u3055\u308c\u305f12806\u4eba\u306e\u5bfe\u8c61\u8005\u306e\u5185\u30014228\u306f\u7121\u6295\u85ac\u7fa4\u30016492\u4eba\u306f\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u5358\u72ec\u3001671\u4eba\u306f\u6297\u83cc\u85ac\u5358\u72ec\u30011415\u4eba\u306f\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u30fb\u6297\u83cc\u85ac\u3092\u51e6\u65b9\u3055\u308c\u305f\u3002\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u306e\u8a3a\u65ad\u306e\u5927\u90e8\u5206\u306f\u75c5\u9662\u6551\u6025\u5916\u6765\u3067\u884c\u308f\u308c\u305f\u3002\u6297\u83cc\u85ac\u3067\u6295\u4e0e\u983b\u5ea6\u304c\u9ad8\u304b\u3063\u305f\u3082\u306e\u306f\u30de\u30af\u30ed\u30e9\u30a4\u30c9\u3001\u30da\u30cb\u30b7\u30ea\u30f3\u3001\u30ad\u30ce\u30ed\u30f3\u7cfb\u3001\u30c6\u30c8\u30e9\u30b5\u30a4\u30af\u30ea\u30f3\u3067\u3042\u3063\u305f\u3002\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u306f\u30aa\u30bb\u30eb\u30bf\u30df\u30d3\u30eb\u304c\u7b46\u982d\u306799.9%\u3092\u5360\u3081\u305f\u3002\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u3068\u6297\u83cc\u85ac\u3092\u51e6\u65b9\u3055\u308c\u305f\u7fa4\u306f\u30c1\u30e3\u30fc\u30eb\u30bd\u30f3\u4f75\u5b58\u75be\u60a3\u6307\u6570(Charlson Comorbidity Index)\u304c\u6700\u3082\u9ad8\u304f(1.62)\u3001\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u7fa4\u306f\u6700\u3082\u4f4e\u304b\u3063\u305f(1.35)\u3002 \u539f\u56e0\u3092\u554f\u308f\u306a\u3044\u5165\u9662\u306e\u5272\u5408\u306f\u3001\u7121\u6295\u85ac\u7fa4\u3067\u6700\u3082\u9ad8\u304f(10.48%)\u3001\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u30fb\u6297\u83cc\u85ac\u4f75\u7528\u7fa4\u3067\u6700\u3082\u4f4e\u304b\u3063\u305f(3.18%)\u3002\u547c\u5438\u5668\u75be\u60a3\u304c\u539f\u56e0\u306e\u5165\u9662\u3067\u3082\u540c\u3058\u50be\u5411\u304c\u307f\u3089\u308c\u3001\u7121\u6295\u85ac\u7fa4\u3067\u6700\u9ad8\u3068\u306a\u308a(6.58%)\u3001\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u30fb\u6297\u83cc\u85ac\u4f75\u7528\u7fa4\u3067\u6700\u4f4e\u3067\u3042\u3063\u305f(1.06%)\u3002\u8a3a\u65ad\u304b\u308930\u65e5\u4ee5\u5185\u3067\u306e\u539f\u56e0\u3092\u554f\u308f\u306a\u3044\u5165\u9662\u306e\u30ea\u30b9\u30af\u306f\u7121\u6295\u85ac\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u3001\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u7fa4\u3067\u306f63%(\u76f8\u5bfe\u5371\u967a\u5ea6RR 0.37\uff1a95%CI 0.32\uff0d0.44)\u3001\u6297\u83cc\u85ac\u5358\u72ec\u7fa4\u3067\u306f57%(RR 0.43 : 95%CI 0.31-0.62)\u3001\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u30fb\u6297\u83cc\u85ac\u4f75\u7528\u7fa4\u3067\u306f72%\u4f4e\u304b\u3063\u305f(RR 0.28:95%CI 0.21-0.38)\u3002\u6cbb\u7642\u85ac\u306e\u6295\u4e0e\u306f\u3001\u6700\u521d\u306e5\u65e5\u9593\u3067\u6700\u3082\u9ad8\u3044\u5165\u9662\u963b\u6b62\u52b9\u679c\u3092\u793a\u3057\u305f\u3002 \u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u30fb\u6297\u83cc\u85ac\u4f75\u7528\u7fa4\u3067\u306f\u3001\u539f\u56e0\u3092\u554f\u308f\u306a\u3044\u5165\u9662\u306e\u30ea\u30b9\u30af\u304c\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u5358\u72ec\u7fa4\u3088\u308a\u3082\u4f4e\u3044\u50be\u5411\u306b\u3042\u3063\u305f\u304c\u3001CI\u306f\u5404\u7d4c\u904e\u671f\u9593\u30671\u3092\u307e\u305f\u3044\u3067\u3044\u305f(\u8abf\u6574\u76f8\u5bfe\u5371\u967a\u5ea6\uff1a\u8a3a\u65ad\u5f8c1\uff0d5\u65e50.67 (95%CI 0.41\uff0d1.11)\u3001\u8a3a\u65ad\u5f8c1\uff0d10\u65e50.67 (95%CI 0.44-1.01)\u3001\u8a3a\u65ad\u5f8c1\uff0d30\u65e50.73 (95%CI0.53\uff0d1.01))\u3002\u547c\u5438\u5668\u75be\u60a3\u306b\u3088\u308b\u5165\u9662\u3067\u3082\u540c\u69d8\u306e\u50be\u5411\u306b\u3042\u3063\u305f\u304c\u3001\u7570\u306a\u308b\u70b9\u306f\u3001\u8a3a\u65ad\u5f8c30\u65e5\u306e\u6642\u70b9\u3067\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u30fb\u6297\u83cc\u85ac\u4f75\u7528\u7fa4\u3067\u306f\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u5358\u72ec\u7fa4\u306b\u5bfe\u3057\u3066\u6709\u610f\u5dee\u3092\u3082\u3063\u3066\u30ea\u30b9\u30af\u304c\u4f4e\u304f\u306a\u3063\u305f(\u8abf\u6574\u76f8\u5bfe\u5371\u967a\u5ea60.53 (95%CI 0.31- 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\u8a3b\uff11\uff1a\u7d39\u4ecb\u8a18\u4e8b\u3067\u306f\u3001\u300c\u95a2\u9023\u3092\u8a8d\u3081\u305f\u300d\u3068\u8a18\u8f09\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u672c\u7814\u7a76\u306f\u89b3\u5bdf\u7814\u7a76\u3067\u3042\u308a\u3001\u8a55\u4fa1\u9805\u76ee\u3068outcome\u306b\u7d71\u8a08\u7684\u95a2\u9023\u3092\u8a8d\u3081\u305f\u3001\u3057\u304b\u3057\u3001\u7814\u7a76\u306e\u6027\u8cea\u4e0a\u56e0\u679c\u95a2\u4fc2\u306f\u8a55\u4fa1\u3067\u304d\u306a\u3044\u3068\u306e\u610f\u5473\u5408\u3044\u304c\u8fbc\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002PRC\u59d4\u54e1\u4f1aB\u30b0\u30eb\u30fc\u30d7\u5185\u3067\u8a0e\u8ad6\u3057\u305f\u7d50\u679c\u3001\u7ffb\u8a33\u3067\u306f\u5185\u5bb9\u7406\u89e3\u3092\u512a\u5148\u3057\u305f\u8868\u73fe\u3068\u3057\u307e\u3057\u305f\u3002\u8a3b\uff12\uff1a\u60a3\u8005\u306e\u4f75\u5b58\u75c7\u3001\u305d\u306e\u5f8c\u306e\u75be\u60a3\u767a\u75c7\u30fb\u5165\u9662\u3001\u51e6\u65b9\u5185\u5bb9\u306f\u4fdd\u967a\u8acb\u6c42\u30c7\u30fc\u30bf\u304b\u3089\u62bd\u51fa \u5143\u306b\u306a\u3063\u305f\u8ad6\u6587\u306f\u4e0b\u8a18\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002Clin Infect Dis. 2020 Jan 24. pii: ciaa074. doi: 10.1093\/cid\/ciaa074. 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