Annals of Internal Medicine \u306eORIGINAL RESEARCH |31 DECEMBER 2019\u3000\u304b\u3089\u306e\u7d39\u4ecb\u3067\u3059\u3002<\/p>\n
Disease-Modifying Effects of a Novel Cathepsin K Inhibitor in Osteoarthritis: A Randomized, Placebo-Controlled Study<\/p>\n
https:\/\/annals.org\/\u2026\/disease-modifying-effects-novel-cathep\u2026<\/a><\/p>\n \u65b0\u898f\u30ab\u30c6\u30d7\u30b7\u30f3K\u963b\u5bb3\u85ac\u306e\u5909\u5f62\u6027\u95a2\u7bc0\u75c7\u306b\u5bfe\u3059\u308b\u75be\u60a3\u4fee\u98fe\u52b9\u679c\uff1a\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13<\/p>\n \u80cc\u666f\uff1aMIV-711\u306f\u65b0\u898f\u9078\u629e\u7684\u30ab\u30c6\u30d7\u30b7\u30f3K\u963b\u5bb3\u85ac\u3067\u3042\u308a\u3001\u5909\u5f62\u6027\u95a2\u7bc0\u75c7\u30e2\u30c7\u30eb\u306e\u524d\u81e8\u5e8a\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u9aa8\u3068\u8edf\u9aa8\u306b\u6709\u76ca\u306a\u52b9\u679c\u3092\u793a\u3057\u3066\u3044\u308b\u3002<\/p>\n \u76ee\u7684\uff1a\u819d\u95a2\u7bc0\u306e\u75c7\u72b6\u304a\u3088\u3073\u30ec\u30f3\u30c8\u30b2\u30f3\u691c\u67fb\u4e0a\u6240\u898b\u3092\u6709\u3059\u308b\u5909\u5f62\u6027\u95a2\u7bc0\u75c7\u3092\u7f79\u60a3\u3059\u308b\u88ab\u9a13\u8005\u306b\u304a\u3044\u3066\u3001MIV-711\u306e\u52b9\u679c\u3001\u5b89\u5168\u6027\u304a\u3088\u3073\u5fcd\u5bb9\u6027\u3092\u8a55\u4fa1\u3059\u308b\u4e8b\u3002<\/p>\n \u30c7\u30b6\u30a4\u30f3\uff1a26\u9031\u9593\u30e9\u30f3\u30c0\u30e0\u5316\u4e8c\u91cd\u76f2\u691c\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\u306e\u30d5\u30a7\u30fc\u30ba2a\u8a66\u9a13\u3068\u3053\u308c\u306b\u5f15\u304d\u7d9a\u304d26\u9031\u9593\u306e\u5b89\u5168\u6027\u306b\u5bfe\u3059\u308b\u30aa\u30fc\u30d7\u30f3\u30e9\u30d9\u30eb\u30b5\u30d6\u8a66\u9a13\u3002<\/p>\n \u30bb\u30c3\u30c6\u30a3\u30f3\u30b0\uff1a\u30e8\u30fc\u30ed\u30c3\u30d1\u306e6\u5730\u57df<\/p>\n \u88ab\u9a13\u8005\uff1aKellgren\u2013Lawrence grade 2 \u3042\u308b\u3044\u306f 3\u3000\u304a\u3088\u3073\u3000\u75bc\u75db\u6570\u5024\u8a55\u4fa1\u30b9\u30b1\u30fc\u30eb\u30674\u304b\u308910\u30b9\u30b3\u30a2\u3092\u6709\u3059\u308b\u521d\u671f\u306e\u5909\u5f62\u6027\u819d\u95a2\u7bc0\u75c7244\u4eba\u3002<\/p>\n \u4ecb\u5165\uff1aMIV-711 100mg\u6295\u4e0e82\u4eba\u3001200mg\u6295\u4e0e81\u4eba\u3001\u5bfe\u7167\u30d7\u30e9\u30bb\u30dc\u6295\u4e0e77\u4eba\u3002200mg\u6295\u4e0e\u306e46\u4eba\u3068\u30d7\u30e9\u30bb\u30dc\u6295\u4e0e\u306e4\u4eba\u306e\u88ab\u9a13\u8005\u306f\u3001\u305d\u306e\u5f8c\u3001\u62e1\u5927\u30b5\u30d6\u8a66\u9a13\uff08MIV-711\uff1a200mg\u6bce\u65e5\u6295\u4e0e\uff09\u306b\u9032\u3093\u3060\u3002<\/p>\n \u8a08\u6e2c\uff1a\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306f\u3001\u75bc\u75db\u6570\u5024\u8a55\u4fa1\u30b9\u30b1\u30fc\u30eb\u306e\u5909\u5316\u3067\u3042\u3063\u305f\u3002\u91cd\u8981\u306a\u4e8c\u6b21\u8a55\u4fa1\u9805\u76ee\u306f\u3001MRI\u691c\u67fb\u306e\u9aa8\u57df\u5909\u5316\u3067\u3042\u3063\u305f\u3002\u305d\u306e\u4ed6\u306e2\u6b21\u8a55\u4fa1\u9805\u76ee\u306b\u306f\u3001\u5b9a\u91cf\u7684MRI\u3067\u306e\u8edf\u9aa8\u5c64\u539a\u3068\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306etype I \u304a\u3088\u3073 II collagen C-telopeptide\u304c\u542b\u307e\u308c\u3066\u3044\u305f\u3002<\/p>\n \u7d50\u679c\uff1a\u75bc\u75db\u6570\u5024\u8a55\u4fa1\u30b9\u30b1\u30fc\u30eb\u306f\u3001\u7d71\u8a08\u5b66\u7684\u306b\u6709\u610f\u306a\u5909\u5316\u304c\u898b\u3089\u308c\u306a\u304b\u3063\u305f\u3002(placebo, \u22121.4; MIV-711, 100 mg\/d, \u22121.7; MIV-711, 200 mg\/d, \u22121.5)\u3000MIV-711\u306f\u3001\u5927\u817f\u9aa8\u306e\u9aa8\u5bc6\u5ea6\u5e73\u5747\u306e\u4f4e\u4e0b\u3092\u8457\u660e\u306b\u6291\u5236\u3000(P = 0.002 for 100 mg\/d and 0.004 for 200 mg\/d)\u3001\u5927\u817f\u9aa8\u5e73\u5747\u8edf\u9aa8\u5c64\u306e\u83f2\u8584\u5316\u3092\u6291\u5236\u3000(P = 0.023 for 100 mg\/d and 0.125 for 200 mg\/d)\u3001\u8457\u660e\u306b\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u5024\u3082\u6291\u5236\u3057\u305f\u30026\u4eba\u306e\u88ab\u9a13\u8005\u306b9\u4ef6\u306e\u91cd\u7be4\u306a\u526f\u53cd\u5fdc\u304c\u3042\u3063\u305f\u30021\u4eba\u306f\u30d7\u30e9\u30bb\u30dc\u7fa4\u30013\u4eba\u306f100mg\u6295\u4e0e\u7fa4\u30012\u4eba\u306f200mg\u6295\u4e0e\u7fa4\u3067\u3042\u3063\u305f\u304c\u3001\u3044\u305a\u308c\u3082\u6cbb\u7642\u306b\u95a2\u9023\u3057\u306a\u3044\u3082\u306e\u3068\u8003\u3048\u3089\u308c\u305f\u3002<\/p>\n \u9650\u754c\uff1a\u6bd4\u8f03\u7684\u77ed\u671f\u9593\u306e\u8a66\u9a13\u3067\u3042\u3063\u305f\u3002<\/p>\n \u7d50\u8ad6\uff1aMIV-711\u306f\u75bc\u75db\u306b\u5bfe\u3057\u3066\u306f\u3001\u30d7\u30e9\u30bb\u30dc\u306b\u8f03\u3079\u6709\u52b9\u3067\u306f\u306a\u304b\u3063\u305f\u3002\u3057\u304b\u3057\u3001\u9ad8\u3044\u5b89\u5168\u6027\u306e\u5074\u9762\u3092\u6709\u3057\u306a\u304c\u3089\u3001\u9aa8\u3068\u8edf\u9aa8\u306e\u75c5\u614b\u9032\u884c\u3092\u6709\u610f\u306b\u6291\u5236\u3057\u305f\u3002\u3053\u306e\u6cbb\u7642\u306f\u3001\u5909\u5f62\u6027\u95a2\u7bc0\u75c7\u306e\u75be\u60a3\u4fee\u98fe\u85ac\u3068\u3057\u3066\u3001\u3055\u3089\u306a\u308b\u8a55\u4fa1\u306b\u5024\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/p>\n \u4e3b\u305f\u308b\u8cc7\u91d1\u6e90\uff1aMedivir\u793e<\/p>\n \uff03\u5909\u5f62\u6027\u95a2\u7bc0\u75c7<\/a> \uff03\u30ab\u30c6\u30d7\u30b7\u30f3K\u963b\u5bb3\u85ac<\/a> Annals of Internal Medicine \u306eORIGINAL RESEARCH |31 DECEMBER 2019\u3000\u304b\u3089\u306e\u7d39\u4ecb\u3067\u3059\u3002 Disease-Modifying Effects of a Novel Cathepsin K Inhibitor in Osteoarthritis: A Randomized, Placebo-Controlled Study https:\/\/annals.org\/\u2026\/disease-modifying-effects-novel-cathep\u2026 \u65b0\u898f\u30ab\u30c6\u30d7\u30b7\u30f3K\u963b\u5bb3\u85ac\u306e\u5909\u5f62\u6027\u95a2\u7bc0\u75c7\u306b\u5bfe\u3059\u308b\u75be\u60a3\u4fee\u98fe\u52b9\u679c\uff1a\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13 \u80cc\u666f\uff1aMIV-711\u306f\u65b0\u898f\u9078\u629e\u7684\u30ab\u30c6\u30d7\u30b7\u30f3K\u963b\u5bb3\u85ac\u3067\u3042\u308a\u3001\u5909\u5f62\u6027\u95a2\u7bc0\u75c7\u30e2\u30c7\u30eb\u306e\u524d\u81e8\u5e8a\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u9aa8\u3068\u8edf\u9aa8\u306b\u6709\u76ca\u306a\u52b9\u679c\u3092\u793a\u3057\u3066\u3044\u308b\u3002 \u76ee\u7684\uff1a\u819d\u95a2\u7bc0\u306e\u75c7\u72b6\u304a\u3088\u3073\u30ec\u30f3\u30c8\u30b2\u30f3\u691c\u67fb\u4e0a\u6240\u898b\u3092\u6709\u3059\u308b\u5909\u5f62\u6027\u95a2\u7bc0\u75c7\u3092\u7f79\u60a3\u3059\u308b\u88ab\u9a13\u8005\u306b\u304a\u3044\u3066\u3001MIV-711\u306e\u52b9\u679c\u3001\u5b89\u5168\u6027\u304a\u3088\u3073\u5fcd\u5bb9\u6027\u3092\u8a55\u4fa1\u3059\u308b\u4e8b\u3002 \u30c7\u30b6\u30a4\u30f3\uff1a26\u9031\u9593\u30e9\u30f3\u30c0\u30e0\u5316\u4e8c\u91cd\u76f2\u691c\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\u306e\u30d5\u30a7\u30fc\u30ba2a\u8a66\u9a13\u3068\u3053\u308c\u306b\u5f15\u304d\u7d9a\u304d26\u9031\u9593\u306e\u5b89\u5168\u6027\u306b\u5bfe\u3059\u308b\u30aa\u30fc\u30d7\u30f3\u30e9\u30d9\u30eb\u30b5\u30d6\u8a66\u9a13\u3002 \u30bb\u30c3\u30c6\u30a3\u30f3\u30b0\uff1a\u30e8\u30fc\u30ed\u30c3\u30d1\u306e6\u5730\u57df \u88ab\u9a13\u8005\uff1aKellgren\u2013Lawrence grade 2 \u3042\u308b\u3044\u306f 3\u3000\u304a\u3088\u3073\u3000\u75bc\u75db\u6570\u5024\u8a55\u4fa1\u30b9\u30b1\u30fc\u30eb\u30674\u304b\u308910\u30b9\u30b3\u30a2\u3092\u6709\u3059\u308b\u521d\u671f\u306e\u5909\u5f62\u6027\u819d\u95a2\u7bc0\u75c7244\u4eba\u3002 \u4ecb\u5165\uff1aMIV-711 100mg\u6295\u4e0e82\u4eba\u3001200mg\u6295\u4e0e81\u4eba\u3001\u5bfe\u7167\u30d7\u30e9\u30bb\u30dc\u6295\u4e0e77\u4eba\u3002200mg\u6295\u4e0e\u306e46\u4eba\u3068\u30d7\u30e9\u30bb\u30dc\u6295\u4e0e\u306e4\u4eba\u306e\u88ab\u9a13\u8005\u306f\u3001\u305d\u306e\u5f8c\u3001\u62e1\u5927\u30b5\u30d6\u8a66\u9a13\uff08MIV-711\uff1a200mg\u6bce\u65e5\u6295\u4e0e\uff09\u306b\u9032\u3093\u3060\u3002 \u8a08\u6e2c\uff1a\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306f\u3001\u75bc\u75db\u6570\u5024\u8a55\u4fa1\u30b9\u30b1\u30fc\u30eb\u306e\u5909\u5316\u3067\u3042\u3063\u305f\u3002\u91cd\u8981\u306a\u4e8c\u6b21\u8a55\u4fa1\u9805\u76ee\u306f\u3001MRI\u691c\u67fb\u306e\u9aa8\u57df\u5909\u5316\u3067\u3042\u3063\u305f\u3002\u305d\u306e\u4ed6\u306e2\u6b21\u8a55\u4fa1\u9805\u76ee\u306b\u306f\u3001\u5b9a\u91cf\u7684MRI\u3067\u306e\u8edf\u9aa8\u5c64\u539a\u3068\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306etype I \u304a\u3088\u3073 II collagen C-telopeptide\u304c\u542b\u307e\u308c\u3066\u3044\u305f\u3002 \u7d50\u679c\uff1a\u75bc\u75db\u6570\u5024\u8a55\u4fa1\u30b9\u30b1\u30fc\u30eb\u306f\u3001\u7d71\u8a08\u5b66\u7684\u306b\u6709\u610f\u306a\u5909\u5316\u304c\u898b\u3089\u308c\u306a\u304b\u3063\u305f\u3002(placebo, \u22121.4; MIV-711, 100 mg\/d, \u22121.7; MIV-711, 200 mg\/d, \u22121.5)\u3000MIV-711\u306f\u3001\u5927\u817f\u9aa8\u306e\u9aa8\u5bc6\u5ea6\u5e73\u5747\u306e\u4f4e\u4e0b\u3092\u8457\u660e\u306b\u6291\u5236\u3000(P = 0.002 for 100 mg\/d and 0.004 for 200 mg\/d)\u3001\u5927\u817f\u9aa8\u5e73\u5747\u8edf\u9aa8\u5c64\u306e\u83f2\u8584\u5316\u3092\u6291\u5236\u3000(P = 0.023 for 100 mg\/d and 0.125 for 200 mg\/d)\u3001\u8457\u660e\u306b\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u5024\u3082\u6291\u5236\u3057\u305f\u30026\u4eba\u306e\u88ab\u9a13\u8005\u306b9\u4ef6\u306e\u91cd\u7be4\u306a\u526f\u53cd\u5fdc\u304c\u3042\u3063\u305f\u30021\u4eba\u306f\u30d7\u30e9\u30bb\u30dc\u7fa4\u30013\u4eba\u306f100mg\u6295\u4e0e\u7fa4\u30012\u4eba\u306f200mg\u6295\u4e0e\u7fa4\u3067\u3042\u3063\u305f\u304c\u3001\u3044\u305a\u308c\u3082\u6cbb\u7642\u306b\u95a2\u9023\u3057\u306a\u3044\u3082\u306e\u3068\u8003\u3048\u3089\u308c\u305f\u3002 \u9650\u754c\uff1a\u6bd4\u8f03\u7684\u77ed\u671f\u9593\u306e\u8a66\u9a13\u3067\u3042\u3063\u305f\u3002 \u7d50\u8ad6\uff1aMIV-711\u306f\u75bc\u75db\u306b\u5bfe\u3057\u3066\u306f\u3001\u30d7\u30e9\u30bb\u30dc\u306b\u8f03\u3079\u6709\u52b9\u3067\u306f\u306a\u304b\u3063\u305f\u3002\u3057\u304b\u3057\u3001\u9ad8\u3044\u5b89\u5168\u6027\u306e\u5074\u9762\u3092\u6709\u3057\u306a\u304c\u3089\u3001\u9aa8\u3068\u8edf\u9aa8\u306e\u75c5\u614b\u9032\u884c\u3092\u6709\u610f\u306b\u6291\u5236\u3057\u305f\u3002\u3053\u306e\u6cbb\u7642\u306f\u3001\u5909\u5f62\u6027\u95a2\u7bc0\u75c7\u306e\u75be\u60a3\u4fee\u98fe\u85ac\u3068\u3057\u3066\u3001\u3055\u3089\u306a\u308b\u8a55\u4fa1\u306b\u5024\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002 \u4e3b\u305f\u308b\u8cc7\u91d1\u6e90\uff1aMedivir\u793e \uff03\u5909\u5f62\u6027\u95a2\u7bc0\u75c7 \uff03\u30ab\u30c6\u30d7\u30b7\u30f3K\u963b\u5bb3\u85ac PRC \u5e73\u91ce\u660c\u4e5f<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"Annals of Internal Medicine \u306eORIGINAL RESEARCH |31 DECEMBER 2019 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\nPRC \u5e73\u91ce\u660c\u4e5f<\/p>\n","protected":false},"excerpt":{"rendered":"