{"id":209,"date":"2017-11-19T01:25:25","date_gmt":"2017-11-19T01:25:25","guid":{"rendered":"https:\/\/plaza.umin.ac.jp\/~ACP\/?page_id=209"},"modified":"2018-09-20T13:24:13","modified_gmt":"2018-09-20T13:24:13","slug":"itc%e7%bf%bb%e8%a8%b3%e3%81%ab%e9%9a%9b%e3%81%97%e3%81%a6%e8%ad%b0%e8%ab%96%e3%81%ae%e3%81%82%e3%81%a3%e3%81%9f%e7%94%a8%e8%aa%9e%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6","status":"publish","type":"page","link":"https:\/\/plaza.umin.ac.jp\/~ACP\/home\/a-homepage-section\/7ff586ad25c74ef934b1\/itc%e7%bf%bb%e8%a8%b3%e3%81%ab%e9%9a%9b%e3%81%97%e3%81%a6%e8%ad%b0%e8%ab%96%e3%81%ae%e3%81%82%e3%81%a3%e3%81%9f%e7%94%a8%e8%aa%9e%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6","title":{"rendered":"ITC_001_\u7ffb\u8a33\u306b\u969b\u3057\u3066\u8b70\u8ad6\u306e\u3042\u3063\u305f\u7528\u8a9e\u306b\u3064\u3044\u3066"},"content":{"rendered":"

ITC001 Hepatitis C Virus\u3092\u7ffb\u8a33\u3057\u305f\u969b\u306b\u63fa\u3089\u304e\u306e\u3042\u3063\u305f\u7528\u8a9e\u306e\u6271\u3044<\/h1>\n
\u4f8b\uff1a\u30eb\u30fc\u30c1\u30f3\uff0f\u30eb\u30fc\u30c1\u30fc\u30f3\u3001\u66dd\u9732\uff0f\u66b4\u9732\u3001DAAs\uff0fDAA\u3001\u518d\u71c3\uff0f\u518d\u767a<\/div>\n
\u85ac\u5264\u540d\u7b49\u306e\u4f8b\uff1a\u30da\u30b0\u30fb\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\uff0f\u30da\u30b0IFN\u3001\u30bd\u30db\u30b9\u30d6\u30d3\u30eb\uff0f\u30bd\u30d5\u30a9\u30b9\u30d6\u30d3\u30eb\u3001\u65e5\u672c\u3067\u627f\u8a8d\u3055\u308c\u3066\u3044\u308b\u85ac\u5264\u306f\u30ab\u30bf\u30ab\u30ca\u8868\u8a18\uff0f\u65e5\u672c\u672a\u627f\u8a8d\u85ac\u5264\u306f\u82f1\u8a9e\u8868\u8a18\u306e\u307e\u307e\u306b\u7d71\u4e00\u3002FDC\u914d\u5408\u9320\u5264\u306f\u3001A\uff0fB\uff0fC\u3068\u8868\u8a18\u3057\u3001\u4f75\u7528\u85ac\u306fA+B\u3068\u8868\u8a18\u3057\u305f<\/div>\n

\u85ac\u5264\u540d\u306ephos-\u3084ciclo-\u306f\u305d\u308c\u305e\u308c\u30db\u30b9\/\u30d5\u30a9\u30b9\u3084\u30b7\u30af\u30ed\/\u30b5\u30a4\u30af\u30ed\u306a\u3069\u306e\u8aad\u307f\u65b9\u3092\u3059\u308b\u5148\u751f\u304c\u6df7\u5728\u3057\u3066\u3044\u308b\u3002\u56fd\u306e\u6a5f\u95a2\u3067\u306f\u4e00\u822c\u540d\u3068\u3057\u3066\u539f\u5247\u4e00\u3064\u306b\u5b9a\u3081\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u308b\u306e\u3067\u78ba\u8a8d\u306e\u3046\u3048\u7d71\u4e00\u3059\u308b\u3002\u7d71\u4e00\u3059\u308b\u969b\u3001\u30de\u30af\u30ed\u3092\u4f7f\u7528\u3059\u308b<\/a>\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u308b\u3002<\/p>\n

    \n
  1. ITC001 Hepatitis C Virus \u306e\u7ffb\u8a33\u306b\u969b\u3057\u3066\u8b70\u8ad6\u3068\u306a\u3063\u305f\u7528\u8a9e<\/strong>
    \n* \u3053\u306e\u7528\u8a9e\u306e\u4f7f\u7528\u3092\u63a8\u5968\u3059\u308b\u3082\u306e\u3067\u306f\u306a\u304f\u3001\u8b70\u8ad6\u306e\u969b\u306e\u6839\u62e0\u3084\u8003\u3048\u65b9\u306e\u53c2\u8003\u306b\u3057\u3066\u304f\u3060\u3055\u3044
    \n\n\n\n\n\t\n\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t
    \u82f1\u8a9e<\/th>\u65e5\u672c\u8a9e\u8a33\u7d71\u4e00\u6848<\/th>\u521d\u51fa\u6642<\/th>\u5099\u8003\u3000\u8b70\u8ad6\u5185\u5bb9\u3001\u6839\u62e0\u306b\u3057\u305f\u8f9e\u66f8\u3084Webpage\u7b49<\/th>\n<\/tr>\n<\/thead>\n
    Weight-based ribavirin<\/td>\u4f53\u91cd\u3067\u7528\u91cf\u8abf\u6574\u3057\u305f\u30ea\u30d0\u30d3\u30ea\u30f3<\/td><\/td><\/td>\n<\/tr>\n
    SVR<\/td>SVR<\/td>SVR(\u30a6\u30a4\u30eb\u30b9\u5b66\u7684\u6301\u7d9a\u9670\u6027\u5316)<\/td>\u6d88\u5316\u5668\u75c5\u5b66\u7528\u8a9e\u96c6\u3088\u308a<\/td>\n<\/tr>\n
    SVR12s<\/td>SVR12 <\/td>\u8a33\u6ce8\uff1a\u6cbb\u7642\u7d42\u4e86 12 \u9031\u9593\u5f8c\u306e\u6642\u70b9\u3067\u8a55\u4fa1\u3057\u305fSVR<\/td>ITC44 \u306e\u30da\u30fc\u30b8\u306b\u3060\u3051\u51fa\u3066\u304f\u308b\u3002
    \n(1\u56de\u3057\u304b\u51fa\u3066\u3053\u306a\u3044\u306e\u3067\u3001\u7d71\u4e00\u3059\u308b\u3079\u304d\u7528\u8a9e\u3068\u306f\u8da3\u65e8\u304c\u9055\u3044\u307e\u3059\u304c\u8abf\u3079\u305f\u3053\u3068\u306e\u30e1\u30e2\u3068\u3057\u3066\uff09\u5143\u8ad6\u6587\u3067\u78ba\u8a8d\u6e08\u307f\u3002http:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(15)00349-9\/abstract<\/td>\n<\/tr>\n
    Treatment-naive<\/td>\u672a\u6cbb\u7642 (\u75c7\u4f8b)
    \n\u672a\u6cbb\u7642 (\u7fa4)<\/td>    		<\/td><\/td>\n<\/tr>\n
    Interferon-experienced (patinets)<\/td>\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u6cbb\u7642\u6b74\u306e\u3042\u308b\u75c7\u4f8b<\/td><\/td><\/td>\n<\/tr>\n
    FDC<\/td>FDC\u9320<\/td>FDC\u9320(\u56fa\u5b9a\u7528\u91cf\u914d\u5408\u9320)<\/td>FDC\u3060\u3051\u3060\u3068\u7406\u89e3\u3057\u306b\u304f\u3044\u3068\u601d\u308f\u308c\u308b\u306e\u3067\u3002\u65e5\u672c\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306f\u300c\u914d\u5408\u9320\u300d\u3067\u3057\u305f\u3002\u305f\u3060\u3001\u300c\u914d\u5408\u9320\u300d\u3060\u3051\u3060\u3068\u3001 fixed dose \u306e\u610f\u5473\u304c\u629c\u3051\u308b\u3002\u4e21\u8005\u306e\u610f\u56f3\u3092\u5165\u308c\u3066\u300c FDC \u914d\u5408\u9320\u300d\u3068\u3057\u307e\u3057\u305f\u3002<\/td>\n<\/tr>\n
    regimen<\/td>\u30ec\u30b8\u30e1\u30f3<\/td><\/td>\u4ed6\u5019\u88dc\uff1a regimen\t \u30d7\u30ed\u30c8\u30b3\u30fc\u30eb\u3001\u6cbb\u7642\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb<\/td>\n<\/tr>\n
    CKD<\/td>\u6162\u6027\u814e\u81d3\u75c5<\/td><\/td>\u65e5\u672c\u814e\u81d3\u5b66\u4f1a HP \u3067\u78ba\u8a8d<\/td>\n<\/tr>\n
    ION-4 trial
    \nC-SURFER study<\/td>    		\u25cf\u25cf \u8a66\u9a13 \u3067\u7d71\u4e00\u3059\u308b<\/td><\/td>\u4ed6\u5019\u88dc\uff1a\u25cf\u25cf\u30c8\u30e9\u30a4\u30a2\u30eb\u3001\u25cf\u25cf\u30b9\u30bf\u30c7\u30a3\u3001\u25cf\u25cf\u7814\u7a76<\/td>\n<\/tr>\n
    Large prospective studies<\/td>\u5927\u898f\u6a21\u81e8\u5e8a\u8a66\u9a13<\/td><\/td>\u89b3\u5bdf\u7814\u7a76\u3060\u3068\u300c\u3044\u308f\u3086\u308b\u300dretrospective\u304c\u5b58\u5728\u3059\u308b\u305f\u3081prospective\u3092\u8a18\u8f09\u3057\u305f\u3044\u6c17\u6301\u3061\u3082\u308f\u304b\u3089\u306a\u304f\u3082\u306a\u3044\u304c\u3001\u81e8\u5e8a\u8a66\u9a13\u306f\u3075\u3064\u3046\u5f8c\u308d\u5411\u304d\u3068\u3044\u3046\u306e\u304c\u8003\u3048\u306b\u304f\u3044\u3002\u307e\u305f\u3001\u89b3\u5bdf\u7814\u7a76\u306e\u9818\u57df\u3067\u3082\u73fe\u5728\u306f\"prospective\" \t\"retrospective\"\u3068\u3044\u3046\u7528\u8a9e\u3092\u305d\u306e\u307e\u307e\u7528\u3044\u308b\u3053\u3068\u306f\u63a8\u5968\u3055\u308c\u306a\u3044\u3002<\/td>\n<\/tr>\n
    DAAs<\/td>DAA<\/td>DAAs \uff08 Direct acting antivirals, \u76f4\u63a5\u578b\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\uff09<\/td>\u300c DAAs\t \u76f4\u63a5\u578b\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u300d\u306b\u95a2\u3057\u3066\u306f\u3001\u65e5\u672c\u809d\u81d3\u5b66\u4f1a\u3001 C \u578b\u809d\u708e\u6cbb\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306b\u3066\u3053\u306e\u7528\u8a9e\u304c\u4f7f\u7528\u3055\u308c\u3066\u3044\u305f\u3002 http:\/\/www.jsh.or.jp\/files\/uploads\/HCV_GL_ver5.1_Oct08_fina_Oct12.pdf<\/td>\n<\/tr>\n
    Antiretroviral treatment\/medication\/regimen<\/td>\u6297\u30ec\u30c8\u30ed\u30a6\u30a4\u30eb\u30b9\u6cbb\u7642
    \n\u6297\u30ec\u30c8\u30ed\u30a6\u30a4\u30eb\u30b9\u85ac
    \n \u6297\u30ec\u30c8\u30ed\u30a6\u30a4\u30eb\u30b9\u30ec\u30b8\u30e1\u30f3<\/td>    		<\/td>\u4e00\u822c\u7684\u306a\u7528\u8a9e\u3067\u3042\u3063\u3066\u3001\u3042\u3048\u3066\u7d71\u4e00\u3057\u306a\u3044\u3068\u610f\u5473\u3059\u308b\u3068\u3053\u308d\u304c\u3042\u3044\u307e\u3044\u306b\u306a\u308b\u3088\u3046\u306a\u3082\u306e\u3067\u306f\u306a\u3044<\/td>\n<\/tr>\n
    Co-infection
    \n ( \u3053\u306e\u8a18\u4e8b\u3067\u306f HIV \u3068 HCV)<\/td>    		\u91cd\u8907\u611f\u67d3<\/td><\/td>\u4ed6\u5019\u88dc\uff1a\u8907\u5408\u611f\u67d3\u3000(\u533b\u5b66\u79d1\u7528\u8a9e\u96c6\u306b\u306fcoinfection\t co-infection\u3068\u3082\u306b\u53ce\u8f09\u306a\u3057\u3002\u539a\u52b4\u7701\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306f\u3001\u91cd\u8907\u611f\u67d3\u306e\u7528\u8a9e\u3068\u306a\u3063\u3066\u3044\u308b\u3002http:\/\/api-net.jfap.or.jp\/library\/guideLine\/images\/2005_HIV_HCV.pdf
    \n
    \nD\u578b\u809d\u708e\u30a6\u30a4\u30eb\u30b9(delta-agent)\u306fB\u578b\u809d\u708e\u30a6\u30a4\u30eb\u30b9\u306b\u611f\u67d3\u3057\u305f\u500b\u4f53\u306b\u611f\u67d3\u3059\u308b\u3002\u307e\u305f\u3001\u30a2\u30c7\u30ce\u968f\u4f34\u30a6\u30a4\u30eb\u30b9\u306f\u611f\u67d3\u3057\u305f\u7d30\u80de\u306b\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\u7b49\u30d8\u30eb\u30d1\u30fc\u30a6\u30a4\u30eb\u30b9\u304c\u611f\u67d3\u3059\u308b\u3053\u3068\u3067\u30a2\u30c7\u30ce\u968f\u4f34\u30a6\u30a4\u30eb\u30b9\u7c92\u5b50\u304c\u8907\u88fd\u30fb\u653e\u51fa\u3055\u308c\u308b\u306a\u3069\u3001\u30e9\u30a4\u30d5\u30b5\u30a4\u30af\u30eb\u306b\u610f\u5473\u306e\u3042\u308b\u91cd\u8907\u611f\u67d3\u3082\u3042\u308b\u3002<\/td>\n<\/tr>\n
    Patients<\/td>\u60a3\u8005\u30fb\u75c7\u4f8b\u30fb\u88ab\u9a13\u8005\uff08\u4f7f\u3044\u5206\u3051\u306f\u5099\u8003\uff09<\/td><\/td>\u75c5\u6c17\u306b\u7f79\u60a3\u3057\u305f\u4eba\u306b\u3064\u3044\u3066\u8ff0\u3079\u308b\u3068\u304d\u306f\u300c\u60a3\u8005\u300d\u3001\u4e8b\u4f8b\u3068\u3057\u3066\u75c5\u614b\u3092\u60a3\u3063\u305f\u30d2\u30c8\u3092\u8ff0\u3079\u308b\u3068\u304d\u306f\u300c\u75c7\u4f8b\u300d\u3001\u81e8\u5e8a\u8a66\u9a13\u306b\u7d44\u307f\u5165\u308c\u3089\u305f\u5bfe\u8c61\u3092\u8ff0\u3079\u308b\u3068\u304d\u306f\u300c\u88ab\u691c\u8005\u300d<\/td>\n<\/tr>\n
    pegIFN<\/td>\u30da\u30b0\u30fb\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3<\/td><\/td>\u539a\u52b4\u7701\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3082\u3053\u306e\u7528\u8a9e\u3092\u4f7f\u7528\u3057\u3066\u3044\u308b\u3002http:\/\/api-net.jfap.or.jp\/library\/guideLine\/images\/2005_HIV_HCV.pdf
    \n\u4ed6\u5019\u88dc\uff1a\u30da\u30b0IFN\t peg IFN\t \u30da\u30b0\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\uff08\u30fb\u306a\u3057\uff09\u3001PEG\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u306a\u3069\u3000<\/td>\n<\/tr>\n
    Drug <\/td>\u6cbb\u7642\u85ac\u306e\u5834\u5408\u306f\u300c\u85ac\u5264\u300d
    \n\u9055\u6cd5\u85ac\u7269\u306e\u5834\u5408\u306f\u300c\u85ac\u7269\u300d<\/td>    		<\/td>\u4f8b\uff1a drug-drug interaction \u21d2 \u85ac\u5264 \u76f8\u4e92\u4f5c\u7528
    \n IVDU \u21d2\u9759\u6ce8\u85ac\u7269<\/td>\n<\/tr>\n
    Herb\t herbal<\/td>\u751f\u85ac<\/td><\/td>\u4ed6\u5019\u88dc\uff1a\u30cf\u30fc\u30d6\u3001\u85ac\u8349\u3001\u6c11\u9593\u7642\u6cd5\u85ac\u3001\u3000<\/td>\n<\/tr>\n
    60mg<\/td>60mg \u3000\uff08 mg \u3067\u8a18\u8f09\uff09<\/td><\/td>\u4ed6\u5019\u88dc\uff1a\u30df\u30ea\u30b0\u30e9\u30e0<\/td>\n<\/tr>\n
    Cytochrome<\/td>\u30c1\u30c8\u30af\u30ed\u30fc\u30e0<\/td><\/td>\u4ed6\u5019\u88dc\uff1a\u30b7\u30c8\u30af\u30ed\u30e0\uff08\u65e5\u672c\u533b\u5b66\u4f1a\u7528\u8a9e\u96c6\u306f\u3053\u306e\u7528\u8a9e\u306b\u306a\u3063\u3066\u3044\u308b\u304c\u3001\u3042\u307e\u308a\u306b\u805e\u304d\u99b4\u67d3\u307f\u304c\u306a\u3044\uff09\u3001\u30c1\u30c8\u30af\u30ed\u30e0\u3001\u30b5\u30a4\u30c8\u30af\u30ed\uff08\uff0d\uff09\u30e0<\/td>\n<\/tr>\n
    Guidance<\/td>\u300c\u6307\u793a\u300d\u300c\u30ac\u30a4\u30c0\u30f3\u30b9\u300d\u300c\u6cbb\u7642\u6307\u91dd\u300d\u300c\u8a3a\u65ad\u6cbb\u7642\u6307\u91dd\u300d\u306e\u306a\u304b\u304b\u3089\u6587\u8108\u306b\u5fdc\u3058\u3066<\/td><\/td><\/td>\n<\/tr>\n
    First-line regimen<\/td>\u7b2c\u4e00\u9078\u629e\u30ec\u30b8\u30e1\u30f3<\/td><\/td>\u4ed6\u5019\u88dc\uff1a\u7b2c\u4e8c\u9078\u629e\u30ec\u30b8\u30e1\u30f3\u3001\u305d\u306e\u4ed6\u306e\u30ec\u30b8\u30e1\u30f3<\/td>\n<\/tr>\n
    Alternative regimen<\/td>\u4ee3\u66ff\u30ec\u30b8\u30e1\u30f3<\/td><\/td><\/td>\n<\/tr>\n
    Monitoring<\/td>\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u3001\u30e2\u30cb\u30bf\u30fc\u3059\u308b<\/td><\/td>\u4ed6\u5019\u88dc\uff1a\u76e3\u8996<\/td>\n<\/tr>\n
    Adherence <\/td>\u30a2\u30c9\u30d2\u30a2\u30e9\u30f3\u30b9<\/td>\u30a2\u30c9\u30d2\u30a2\u30e9\u30f3\u30b9\uff08\u670d\u85ac\u30b3\u30f3\u30d7\u30e9\u30a4\u30a2\u30f3\u30b9\uff09<\/td>\u7406\u7531\uff1a\u670d\u85ac\u30b3\u30f3\u30d7\u30e9\u30a4\u30a2\u30f3\u30b9\u306e\u65b9\u304c\u3001\u65e5\u672c\u3067\u306f\u5727\u5012\u7684\u306b\u591a\u6570\u306e\u533b\u5e2b\u306b\u7406\u89e3\u3055\u308c\u3084\u3059\u3044\u3002\u305f\u3060\u3057\u3001\u3053\u308c\u304b\u3089\u306f\u30b3\u30f3\u30d7\u30e9\u30a4\u30a2\u30f3\u30b9\u3092\u3001\u30a2\u30c9\u30d2\u30a2\u30e9\u30f3\u30b9\u306b\u3057\u3066\u3044\u3053\u3046\u3068\u3044\u3046\u6642\u4ee3\u306e\u65b9\u5411\u6027\u306e\u305f\u3081\u3002<\/td>\n<\/tr>\n
    Risk factor<\/td>\u30ea\u30b9\u30af\u56e0\u5b50<\/td><\/td>\u4ed6\u5019\u88dc\uff1a\u5371\u967a\u56e0\u5b50\u3001\u30ea\u30b9\u30af\u30d5\u30a1\u30af\u30bf\u30fc<\/td>\n<\/tr>\n
    Ongoing risk<\/td>\u7d99\u7d9a\u7684\u306a\u30ea\u30b9\u30af<\/td><\/td><\/td>\n<\/tr>\n
    Fatigue<\/td>\u5026\u6020\u611f<\/td><\/td>\u4ed6\u5019\u88dc\uff1a\u75b2\u52b4\u3001\u5168\u8eab\u5026\u6020\u611f\u3001\u75b2\u52b4<\/td>\n<\/tr>\n
    Specialist<\/td>\u5c02\u9580\u533b<\/td><\/td>\u4ed6\u5019\u88dc\uff1a\u5c02\u9580\u5bb6\u3001\u30b9\u30da\u30b7\u30e3\u30ea\u30b9\u30c8<\/td>\n<\/tr>\n
    Manage\t management<\/td>\u7ba1\u7406<\/td><\/td>\u4ed6\u5019\u88dc\uff1a\u30de\u30cd\u30b8\u30e1\u30f3\u30c8\u3000<\/td>\n<\/tr>\n
    Exposure<\/td>\u66dd\u9732<\/td><\/td>\u4ed6\u5019\u88dc\uff1a\u66b4\u9732\uff08\u4e0d\u6b63\u3092\u66b4\u9732\u306a\u3069\u300c\u3042\u3070\u304f\u300d\u306e\u30cb\u30e5\u30a2\u30f3\u30b9\u304c\u3042\u308b\u304c\u3001\u9593\u9055\u3044\u3068\u3082\u3044\u3048\u306a\u3044\uff09<\/td>\n<\/tr>\n
    Routine <\/td>\u30eb\u30fc\u30c1\u30f3<\/td><\/td>\u4ed6\u5019\u88dc\uff1a\u30eb\u30fc\u30c1\u30fc\u30f3<\/td>\n<\/tr>\n
    Relapse <\/td>\uff08 HCV \u306e\u5834\u5408\u306f\uff09\u300c\u518d\u71c3\u300d\u3068\u3057\u3066\u3044\u308b\u3002<\/td><\/td>\u4ed6\u5019\u88dc\uff1a\u518d\u767a\u3000\u30a6\u30a4\u30eb\u30b9\u306b\u6ce8\u76ee\u3059\u308b\u5834\u5408\u306f\u300creactivation ;\u518d\u6d3b\u6027\u5316\u300d\u3000\u304c\u4f7f\u7528\u3055\u308c\u308b\u5834\u5408\u3082\u3042\u308a\u3001\u30a6\u30a4\u30eb\u30b9\u306e\u9818\u57df\u306b\u3088\u3063\u3066relapse\u3068\u306f\u4f7f\u3044\u5206\u3051\u3089\u308c\u3066\u3044\u308b\u306e\u3067\u3001\u8981\u6ce8\u610f\u3002<\/td>\n<\/tr>\n
    genotype \u3000<\/td>genotype<\/td><\/td>genotype 1
    \ngenotype 2
    \n\u306a\u3069
    \n\uff08\u65e5\u672c\u809d\u81d3\u75c5\u5b66\u4f1a\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306f\u30b2\u30ce\u30bf\u30a4\u30d7 1 \u578b\u3001\u30b2\u30ce\u30bf\u30a4\u30d7 2 \u578b\u306e\u8a18\u8f09\uff09<\/td>\n<\/tr>\n
    subtype<\/td>subtype<\/td><\/td>\u4ed6\u5019\u88dc\uff1a\u30b5\u30d6\u30bf\u30a4\u30d7\u3000<\/td>\n<\/tr>\n
    PWID<\/td>PWID<\/td>PWID (people who inject drugs)<\/td><\/td>\n<\/tr>\n
    MSM<\/td>\u7537\u6027\u540c\u6027\u611b\u8005<\/td>\u7537\u6027\u540c\u6027\u611b\u8005\uff08 MSM: men who have sex with men \uff09<\/td><\/td>\n<\/tr>\n
    Pangenotypic regimen<\/td>Pangenotypic regimen<\/td>Pangenotypic regimen (\u6c4e\u907a\u4f1d\u5b50\u578b\u85ac\u7269\u30ec\u30b8\u30e1\u30f3)\u3000\u8a33\u6ce8\uff1a\u3069\u306egenotype\u306b\u5bfe\u3057\u3066\u3082\u666e\u904d\u7684\u306b\u6709\u52b9\u306a\u85ac\u7269\u30ec\u30b8\u30e1\u30f3<\/td><\/td>\n<\/tr>\n
    FDC \u88fd\u5264\u3068\u3001\u4f75\u7528\u85ac\u306e\u85ac\u52b9\u6210\u5206\u306e\u8a18\u8f09\u65b9\u6cd5<\/td>\u3000<\/td><\/td>FDC \u88fd\u5264\uff08\uff1d\u914d\u5408\u9320\uff09\u306f A\/B\/C \u3068\u8a18\u8f09\u3059\u308b\u3002\u4f75\u7528\u85ac\u306f\u3000 A+B+C \u3068\u8a18\u8f09\u3059\u308b<\/td>\n<\/tr>\n
    Dose<\/td>\u7528\u91cf<\/td><\/td><\/td>\n<\/tr>\n
    Dosing<\/td>\u6295\u4e0e\u3059\u308b\u4e8b\u30fb\u6295\u4e0e\u65b9\u6cd5<\/td><\/td><\/td>\n<\/tr>\n
    Mortality and morbidity<\/td>\u6b7b\u4ea1\u7387\u304a\u3088\u3073\u7f79\u60a3\u7387<\/td><\/td><\/td>\n<\/tr>\n
    \u300c\u306a\u3069\u300d\u306f\u6f22\u5b57\u3067\u7d71\u4e00\u3059\u308b\u3002\u3086\u3048\u306b\u300c\u7b49\u300d\u3068\u8a18\u8f09\u3059\u308b\u3000<\/td><\/td><\/td><\/td>\n<\/tr>\n
    Liver transplantation<\/td>\u809d\u79fb\u690d<\/td><\/td>\u4ed6\u5019\u88dc\uff1a\u809d\u81d3\u79fb\u690d
    \n\u65e5\u672c\u533b\u5b66\u4f1a\u7528\u8a9e\u96c6\u3082\u809d\u79fb\u690d<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/li>\n
  2. ITC002\u00a0Hepatitis C Virus \u306e\u7ffb\u8a33\u6642\u306b\u7d71\u4e00\u3057\u305f\u533b\u85ac\u54c1
    \n<\/strong>*\uff08\u6d77\u5916\u3067\u627f\u8a8d\u3055\u308c\u3066\u3044\u308b\uff09\u533b\u85ac\u54c1\u306e\u56fd\u5185\u3067\u306e\u627f\u8a8d\u72b6\u6cc1\u306f\u6642\u9593\u3068\u3068\u3082\u306b\u5909\u5316\u3057\u307e\u3059\u3002\u305d\u306e\u6642\u3005\u3067\u78ba\u8a8d\u3057\u3066\u304f\u3060\u3055\u3044
    \n<\/strong>\n\n\n\n\t\n\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t
    drug<\/th>PMDA \u691c\u7d22\uff08\u5317\u91ce\uff09<\/th>\u65e5\u672c\u306b\uff08\u5317\u91ce\u691c\u7d22\uff09<\/th>\u4e2d\u8597\u3055\u3093\u60c5\u5831<\/th>\n<\/tr>\n<\/thead>\n
    sofosbuvir<\/td>\u30bd\u30db\u30b9\u30d6\u30d3\u30eb<\/td>\u3042\u308a<\/td>\u3042\u308a<\/td>\n<\/tr>\n
    ribavirin<\/td>\u30ea\u30d0\u30d3\u30ea\u30f3<\/td>\u3042\u308a<\/td>\u3042\u308a<\/td>\n<\/tr>\n
    boceprevir<\/td>\u691c\u7d22\u3055\u308c\u306a\u3044<\/td>\u306a\u3057<\/td>\u672a\u627f\u8a8d<\/td>\n<\/tr>\n
    telaprevir<\/td>\u30c6\u30e9\u30d7\u30ec\u30d3\u30eb<\/td>\u3042\u308a<\/td><\/td>\n<\/tr>\n
    paritaprevir<\/td>\u30d1\u30ea\u30bf\u30d7\u30ec\u30d3\u30eb<\/td>\u914d\u5408\u9320\u3068\u3057\u3066\u3042\u308a<\/td>\u3042\u308a<\/td>\n<\/tr>\n
    ritonavir<\/td>\u30ea\u30c8\u30ca\u30d3\u30eb<\/td>\u3042\u308a<\/td><\/td>\n<\/tr>\n
    ombitasvir<\/td>\u30aa\u30e0\u30d3\u30bf\u30b9\u30d3\u30eb<\/td>\u914d\u5408\u9320\u3068\u3057\u3066\u3042\u308a<\/td>\u3042\u308a<\/td>\n<\/tr>\n
    dasabuvir<\/td>\u691c\u7d22\u3055\u308c\u306a\u3044<\/td>\u306a\u3057<\/td>\u672a\u627f\u8a8d<\/td>\n<\/tr>\n
    daclatasvir<\/td>\u30c0\u30af\u30e9\u30bf\u30b9\u30d3\u30eb<\/td>\u3042\u308a<\/td>\u3042\u308a<\/td>\n<\/tr>\n
    velpatasvir<\/td>\u691c\u7d22\u3055\u308c\u306a\u3044<\/td>\u306a\u3057<\/td>\u672a\u627f\u8a8d<\/td>\n<\/tr>\n
    elbasvir<\/td>\u691c\u7d22\u3055\u308c\u306a\u3044<\/td>\u306a\u3057<\/td>\u30a8\u30eb\u30d0\u30b9\u30d3\u30eb\u3068\u3057\u3066\u5be9\u67fb\u9032\u884c\u4e2d<\/td>\n<\/tr>\n
    grazoprevir<\/td>\u691c\u7d22\u3055\u308c\u306a\u3044<\/td>\u306a\u3057<\/td>\u30b0\u30e9\u30be\u30d7\u30ec\u30d3\u30eb\u3068\u3057\u3066\u5be9\u67fb\u9032\u884c\u4e2d<\/td>\n<\/tr>\n
    ledipasvir<\/td>\u30ec\u30b8\u30d1\u30b9\u30d3\u30eb<\/td>\u914d\u5408\u9320\u3068\u3057\u3066\u3042\u308a<\/td><\/td>\n<\/tr>\n
    simeprevir<\/td>\u30b7\u30e1\u30d7\u30ec\u30d3\u30eb<\/td>\u3042\u308a<\/td><\/td>\n<\/tr>\n
    tenofovir<\/td>\u30c6\u30ce\u30db\u30d3\u30eb<\/td>\u3042\u308a<\/td><\/td>\n<\/tr>\n
    efavirenz<\/td>\u30a8\u30d5\u30a1\u30d3\u30ec\u30f3\u30c4<\/td>\u3042\u308a<\/td><\/td>\n<\/tr>\n
    rilpivirine<\/td>\u30ea\u30eb\u30d4\u30d3\u30ea\u30f3<\/td>\u3042\u308a<\/td><\/td>\n<\/tr>\n
    raltegravir<\/td>\u30e9\u30eb\u30c6\u30b0\u30e9\u30d3\u30eb<\/td>\u3042\u308a<\/td><\/td>\n<\/tr>\n
    tipranavir<\/td>\u691c\u7d22\u3055\u308c\u306a\u3044<\/td>\u306a\u3057<\/td>\u672a\u627f\u8a8d<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/li>\n<\/ol>\n

     <\/p>\n

    \u53c2\u8003\u8cc7\u6599\u3000(PHARM STAGE vol.12, No.2 2012 pp 12 -23)\uff1a\u3061\u306a\u307f\u306bdosing(\u52d5\u8a5e\u7684\u306a\u7528\u6cd5)\u3060\u3068\u6295\u4e0e\u3059\u308b\u3053\u3068\u3001\u6295\u4e0e\u65b9\u6cd5\u3067\u3001\u4ee5\u4e0b\u306e\u8cc7\u6599\u3067\u3044\u3046dosage\u306b\u8fd1\u304f\u306a\u308a\u307e\u3059\u3002\"\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

    ITC001 Hepatitis C Virus\u3092\u7ffb\u8a33\u3057\u305f\u969b\u306b\u63fa\u3089\u304e\u306e\u3042\u3063\u305f\u7528\u8a9e\u306e\u6271\u3044 \u4f8b\uff1a\u30eb\u30fc\u30c1\u30f3\uff0f\u30eb\u30fc\u30c1\u30fc\u30f3\u3001\u66dd\u9732\uff0f\u66b4\u9732\u3001DAAs\uff0fDAA\u3001\u518d\u71c3\uff0f\u518d\u767a \u85ac\u5264\u540d\u7b49\u306e\u4f8b\uff1a\u30da\u30b0\u30fb\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\uff0f\u30da\u30b0IFN\u3001\u30bd\u30db\u30b9\u30d6\u30d3\u30eb\uff0f\u30bd\u30d5\u30a9\u30b9\u30d6\u30d3\u30eb\u3001\u65e5\u672c\u3067\u627f\u8a8d\u3055\u308c\u3066\u3044\u308b\u85ac\u5264\u306f\u30ab\u30bf\u30ab\u30ca\u8868\u8a18\uff0f\u65e5\u672c\u672a\u627f\u8a8d\u85ac\u5264\u306f\u82f1\u8a9e\u8868\u8a18\u306e\u307e\u307e\u306b\u7d71\u4e00\u3002FDC\u914d\u5408\u9320\u5264\u306f\u3001A\uff0fB\uff0fC\u3068\u8868\u8a18\u3057\u3001\u4f75\u7528\u85ac\u306fA+B\u3068\u8868\u8a18\u3057\u305f \u85ac\u5264\u540d\u306ephos-\u3084ciclo-\u306f\u305d\u308c\u305e\u308c\u30db\u30b9\/\u30d5\u30a9\u30b9\u3084\u30b7\u30af\u30ed\/\u30b5\u30a4\u30af\u30ed\u306a\u3069\u306e\u8aad\u307f\u65b9\u3092\u3059\u308b\u5148\u751f\u304c\u6df7\u5728\u3057\u3066\u3044\u308b\u3002\u56fd\u306e\u6a5f\u95a2\u3067\u306f\u4e00\u822c\u540d\u3068\u3057\u3066\u539f\u5247\u4e00\u3064\u306b\u5b9a\u3081\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u308b\u306e\u3067\u78ba\u8a8d\u306e\u3046\u3048\u7d71\u4e00\u3059\u308b\u3002\u7d71\u4e00\u3059\u308b\u969b\u3001\u30de\u30af\u30ed\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u308b\u3002 ITC001 Hepatitis C Virus \u306e\u7ffb\u8a33\u306b\u969b\u3057\u3066\u8b70\u8ad6\u3068\u306a\u3063\u305f\u7528\u8a9e * \u3053\u306e\u7528\u8a9e\u306e\u4f7f\u7528\u3092\u63a8\u5968\u3059\u308b\u3082\u306e\u3067\u306f\u306a\u304f\u3001\u8b70\u8ad6\u306e\u969b\u306e\u6839\u62e0\u3084\u8003\u3048\u65b9\u306e\u53c2\u8003\u306b\u3057\u3066\u304f\u3060\u3055\u3044 ITC002\u00a0Hepatitis C Virus \u306e\u7ffb\u8a33\u6642\u306b\u7d71\u4e00\u3057\u305f\u533b\u85ac\u54c1 *\uff08\u6d77\u5916\u3067\u627f\u8a8d\u3055\u308c\u3066\u3044\u308b\uff09\u533b\u85ac\u54c1\u306e\u56fd\u5185\u3067\u306e\u627f\u8a8d\u72b6\u6cc1\u306f\u6642\u9593\u3068\u3068\u3082\u306b\u5909\u5316\u3057\u307e\u3059\u3002\u305d\u306e\u6642\u3005\u3067\u78ba\u8a8d\u3057\u3066\u304f\u3060\u3055\u3044   \u53c2\u8003\u8cc7\u6599\u3000(PHARM STAGE vol.12, No.2 2012 pp 12 -23)\uff1a\u3061\u306a\u307f\u306bdosing(\u52d5\u8a5e\u7684\u306a\u7528\u6cd5)\u3060\u3068\u6295\u4e0e\u3059\u308b\u3053\u3068\u3001\u6295\u4e0e\u65b9\u6cd5\u3067\u3001\u4ee5\u4e0b\u306e\u8cc7\u6599\u3067\u3044\u3046dosage\u306b\u8fd1\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":154,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"jetpack_post_was_ever_published":false,"footnotes":""},"class_list":["post-209","page","type-page","status-publish","hentry"],"aioseo_notices":[],"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/P9nUTT-3n","jetpack_likes_enabled":true,"jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/plaza.umin.ac.jp\/~ACP\/wp-json\/wp\/v2\/pages\/209","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plaza.umin.ac.jp\/~ACP\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/plaza.umin.ac.jp\/~ACP\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~ACP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~ACP\/wp-json\/wp\/v2\/comments?post=209"}],"version-history":[{"count":24,"href":"https:\/\/plaza.umin.ac.jp\/~ACP\/wp-json\/wp\/v2\/pages\/209\/revisions"}],"predecessor-version":[{"id":582,"href":"https:\/\/plaza.umin.ac.jp\/~ACP\/wp-json\/wp\/v2\/pages\/209\/revisions\/582"}],"up":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/~ACP\/wp-json\/wp\/v2\/pages\/154"}],"wp:attachment":[{"href":"https:\/\/plaza.umin.ac.jp\/~ACP\/wp-json\/wp\/v2\/media?parent=209"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}