{"id":686,"date":"2025-02-03T09:55:51","date_gmt":"2025-02-03T00:55:51","guid":{"rendered":"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/?page_id=686"},"modified":"2026-02-12T18:00:25","modified_gmt":"2026-02-12T09:00:25","slug":"about-1","status":"publish","type":"page","link":"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/about\/about-1\/","title":{"rendered":"\u7dda\u866b\u306f\u3069\u3093\u306a\u751f\u304d\u7269\u306a\u306e\uff1f"},"content":{"rendered":"\n<div id=\"toc_container\" class=\"wp-block-group pada_30\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h2 class=\"wp-block-heading\">\u76ee\u6b21<\/h2>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:45%\">\n<ul class=\"wp-block-list list_none has-medium-font-size\">\n<li><strong><a href=\"#section-1\" data-type=\"internal\" data-id=\"#section-1\">\u7dda\u866b\u3068\u306f<\/a><\/strong><\/li>\n\n\n\n<li><strong><a href=\"#section-2\">\u7dda\u866b\u306e\u4f53\u3068\u6027<\/a><\/strong><\/li>\n\n\n\n<li><strong><a href=\"#section-3\">\u7dda\u866b\u7814\u7a76\u306e\u6b74\u53f2<\/a><\/strong><\/li>\n\n\n\n<li><strong><a href=\"#section-4\">\u30b2\u30ce\u30e0\u30fb\u907a\u4f1d\u5b50<\/a><\/strong><\/li>\n\n\n\n<li><strong><a href=\"#section-5\">\u7dda\u866b\u306e\u7814\u7a76\u3068\u30ce\u30fc\u30d9\u30eb\u8cde<\/a><\/strong><\/li>\n\n\n\n<li><strong><a href=\"#section-6\">\u533b\u7642\u30fb\u7523\u696d\u754c\u3078\u306e\u5fdc\u7528<\/a><\/strong><\/li>\n<\/ul>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:55%\">\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"779\" src=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/06\/1808468ee5ba7c8e77144ffc03836a8f-1024x779.png\" alt=\"\" class=\"wp-image-1069\" srcset=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/06\/1808468ee5ba7c8e77144ffc03836a8f-1024x779.png 1024w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/06\/1808468ee5ba7c8e77144ffc03836a8f-300x228.png 300w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/06\/1808468ee5ba7c8e77144ffc03836a8f-768x584.png 768w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/06\/1808468ee5ba7c8e77144ffc03836a8f-670x510.png 670w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/06\/1808468ee5ba7c8e77144ffc03836a8f.png 1163w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"has-text-align-right\">Illustrated by Hiroko Uchida&nbsp;<\/p>\n\n\n\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p style=\"font-size:1.2em\">\u300c\u7dda\u866b\u300d\u3068\u805e\u304f\u3068\u3001\u56de\u866b\u3084\u304e\u3087\u3046\u866b\u3001\u30a2\u30cb\u30b5\u30ad\u30b9\u3068\u3044\u3063\u305f\u5bc4\u751f\u751f\u7269\u305f\u3061\u3092\u30a4\u30e1\u30fc\u30b8\u3059\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u5927\u304d\u306a\u5206\u985e\u3067\u306f\u3053\u308c\u3089\u3082\u7dda\u5f62\u52d5\u7269\uff08Nematoda\uff09\u306e\u4ef2\u9593\u3067\u306f\u3042\u308a\u307e\u3059\u304c\u3001\u79c1\u305f\u3061\u306f\u305d\u306e\u4e2d\u3067\u3082\u5bc4\u751f\u6027\u3092\u3082\u305f\u306a\u3044\u30a8\u30ec\u30ac\u30f3\u30b9\u7dda\u866b\uff08<em>Caenorhabditis elegans<\/em>\uff09\u3084\u305d\u306e\u8fd1\u7e01\u7a2e\u3092\u7528\u3044\u305f\u7814\u7a76\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059<\/p>\n\n\n\n<p style=\"font-size:1.2em\">\u30a8\u30ec\u30ac\u30f3\u30b9\u7dda\u866b\u306f\u308f\u305a\u304b959\u500b\uff08\u30d2\u30c8\u306f\u7d0437\u5146\u500b\uff09\u306e\u7d30\u80de\u304b\u3089\u306a\u308b\u591a\u7d30\u80de\u751f\u7269\u3067\u3042\u308a\u306a\u304c\u3089\u3001\u79c1\u305f\u3061\u3068\u540c\u69d8\u306b\u795e\u7d4c\u7cfb\uff08\u8133\uff09\u3084\u751f\u6b96\u817a\u3092\u6709\u3059\u308b\u3001\u7acb\u6d3e\u306a\u52d5\u7269\u306e\u4ef2\u9593\u3067\u3059\u3002\u8133\u3092\u4ecb\u3057\u3066\u5916\u754c\u306e\u74b0\u5883\u3092\u8a18\u61b6\u30fb\u5b66\u7fd2\u3057\u3001\u307e\u305f\u4ea4\u914d\u306b\u3088\u3063\u3066\u591a\u69d8\u306a\u5b50\u5b6b\u3092\u6b8b\u3059\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p style=\"font-size:1.2em\">\u3068\u306f\u3044\u3048\u306a\u305c\u7dda\u866b\u3092\u7814\u7a76\u3059\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f\u305d\u308c\u306f\u79c1\u305f\u3061\uff08<em>Homo sapiens<\/em>\uff09\u81ea\u8eab\u306e\u4f53\u306e\u3064\u304f\u308a\u3084\u8133\u306e\u50cd\u304d\u3092\u7406\u89e3\u3059\u308b\u305f\u3081\u306b\u307b\u304b\u306a\u308a\u307e\u305b\u3093\u3002\u305f\u3068\u3048\u3070\u751f\u7269\u306e\u907a\u4f1d\u306e\u3057\u304f\u307f\u306f\u30a8\u30f3\u30c9\u30a6\u8c46\u30fb\u5927\u8178\u83cc\u30fb\u30a6\u30a4\u30eb\u30b9\u3068\u3044\u3063\u305f\u3001\u5b9f\u9a13\u5ba4\u3067\u53d6\u308a\u6271\u3044\u3084\u3059\u3044\u5bfe\u8c61\u306e\u7814\u7a76\u3092\u901a\u3058\u3066\u89e3\u304d\u660e\u304b\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u540c\u69d8\u306b\u5b9f\u9a13\u5ba4\u3067\u53d6\u308a\u6271\u3044\u3084\u3059\u3044\u52d5\u7269\u3068\u3057\u3066\u306e\u7dda\u866b\u3092\u7814\u7a76\u3059\u308b\u3053\u3068\u3067\u3001\u52d5\u7269\u3068\u3057\u3066\u306e\u79c1\u305f\u3061\u306b\u3064\u3044\u3066\u7406\u89e3\u3092\u6df1\u3081\u305f\u3044\u3002\u305d\u308c\u304c\u672c\u30b3\u30df\u30e5\u30cb\u30c6\u30a3\uff08\u866b\u306e\u96c6\u3044\uff09\u306e\u5171\u901a\u7406\u5ff5\u3067\u3059\u3002<\/p>\n\n\n\n<p style=\"font-size:1.2em\">\u9060\u3044\u3088\u3046\u3067\u8fd1\u3044\u7dda\u866b\u306e\u7814\u7a76\u3092\u901a\u3058\u3066\u4f55\u304c\u3069\u3053\u307e\u3067\u308f\u304b\u3063\u3066\u304d\u305f\u306e\u304b\u3001\u307e\u305f\u3053\u308c\u304b\u3089\u3069\u306e\u3088\u3046\u306a\u3053\u3068\u3092\u89e3\u304d\u660e\u304b\u305d\u3046\u3068\u3057\u3066\u3044\u308b\u306e\u304b\u3001\u672cHP\u5168\u4f53\u3092\u901a\u3058\u3066\u5c11\u3057\u3067\u3082\u4f1d\u308f\u308c\u3070\u5b09\u3057\u304f\u601d\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p style=\"font-size:1.2em\"><strong>\u76e3\u4fee\u8005<\/strong><br>\u6c60\u7530\u3000\u5b97\u6a39\u30001989\u5e74\u6771\u4eac\u90fd\u751f\u307e\u308c\u3002\u540d\u53e4\u5c4b\u5927\u5b66\u5927\u5b66\u9662\u535a\u58eb\u8ab2\u7a0b\u4fee\u4e86\u3002\u73fe\u5728\u3001\u30ab\u30ea\u30d5\u30a9\u30eb\u30cb\u30a2\u5927\u5b66\u30b5\u30f3\u30d5\u30e9\u30f3\u30b7\u30b9\u30b3\u6821\u30dd\u30b9\u30c8\u30c9\u30af\u30c8\u30e9\u30eb\u30d5\u30a7\u30ed\u30fc\u306a\u3089\u3073\u306b\u65e5\u672c\u5b66\u8853\u632f\u8208\u4f1a\u7279\u5225\u7814\u7a76\u54e1\u3068\u3057\u3066\u3001\u7dda\u866b\u306b\u304a\u3051\u308b\u9ad8\u6b21\u77e5\u899a\u3084\u8a8d\u77e5\u3001\u610f\u8b58\u7d4c\u9a13\u306a\u3069\u306e\u7814\u7a76\u53ef\u80fd\u6027\u306b\u3064\u3044\u3066\u6a21\u7d22\u3057\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p class=\"has-text-align-right has-small-font-size\">\u00a92026 \u866b\u306e\u96c6\u3044\uff08\u7dda\u866b\u7814\u7a76\u8005\u30b3\u30df\u30e5\u30cb\u30c6\u30a3\uff09\u300c\u5e8f\u8ad6\u300d<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">CC BY<\/a><\/p>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<section id=\"section-1\" class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h3 class=\"wp-block-heading\">1.\u3000\u7dda\u866b\u3068\u306f<\/h3>\n\n\n\n<h4 class=\"wp-block-heading\">\uff08\uff11\uff09\u300c\u7dda\u866b\u300d\u3068\u306f\u4f55\u304b<\/h4>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p>\u300c\u7dda\u866b\u300d\u3068\u805e\u304f\u3068\u7dda\u5f62\u52d5\u7269\u9580\u306b\u5c5e\u3059\u308b\u52d5\u7269\u4e00\u822c\u3092\u601d\u3044\u6d6e\u304b\u3079\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u304c\u3001\u3053\u306eHP\u3092\u904b\u55b6\u3059\u308b\u300c\u866b\u306e\u96c6\u3044\u300d\u3067\u306f\u3001\u4e3b\u306b\u571f\u58cc\u81ea\u6d3b\u7dda\u866b<em>Caenorhabditis elegans<\/em>\uff08\u7565\u79f0<em>C. elegans<\/em> \u30b7\u30fc\u30fb\u30a8\u30ec\u30ac\u30f3\u30b9\uff09\u306e\u3053\u3068\u3092\u6307\u3057\u307e\u3059\u3002<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" width=\"347\" height=\"236\" src=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/06\/5bde7b9f9dc26c4580b13cf6034b4dd7.jpg\" alt=\"\" class=\"wp-image-1086\" style=\"width:404px;height:auto\" srcset=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/06\/5bde7b9f9dc26c4580b13cf6034b4dd7.jpg 347w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/06\/5bde7b9f9dc26c4580b13cf6034b4dd7-300x204.jpg 300w\" sizes=\"(max-width: 347px) 100vw, 347px\" \/><\/figure>\n<\/div><\/div>\n<\/div>\n\n\n\n<p><em>C. elegans<\/em>\u306f\u3001\u305d\u306e\u540d\u306e\u901a\u308a\u30a8\u30ec\u30ac\u30f3\u30c8\u306a\u866b\u3067\u3001\u4f53\u9577\u7d041mm\u306e\u7d30\u9577\u304f\u900f\u660e\u306a\u4f53\u3092\u3082\u3063\u3066\u3044\u307e\u3059\u3002\u500b\u4f53\u5dee\u304c\u307b\u3068\u3093\u3069\u306a\u304f\u3001\u5149\u5b66\u9855\u5fae\u93e1\u3067959\u500b\u306e\u4f53\u7d30\u80de\u3092\u3072\u3068\u3064\u3072\u3068\u3064\u540c\u5b9a\u3067\u304d\u307e\u3059\u3002\u5bd2\u5929\u57f9\u5730\u4e0a\u3067\u80b2\u3066\u305f\u5927\u8178\u83cc\u3092\u3048\u3055\u3068\u3057\u3066\u3001\u7c21\u5358\u306b\u98fc\u3046\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u96cc\u96c4\u540c\u4f53\u3068\u96c4\u304c\u3044\u3066\u30011\u5339\u306e\u96cc\u96c4\u540c\u4f53\u306f\u81ea\u5bb6\u53d7\u7cbe\u3092\u884c\u306a\u3063\u3066\u7d04300\u500b\u306e\u5375\u3092\u7523\u307f\u3001\u5375\u306f\u7d043\u65e5\u3067\u6210\u866b\u306b\u306a\u3063\u3066\u307e\u305f\u7523\u5375\u3057\u307e\u3059\u3002\u69d8\u3005\u306a\u5909\u7570\u4f53\u3092\u5206\u96e2\u3067\u304d\u3001\u96c4\u3092\u4f7f\u3046\u3068\u4ea4\u96d1\u304c\u3067\u304d\u308b\u306e\u3067\u907a\u4f1d\u5b66\u5b9f\u9a13\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4e16\u754c\u4e2d\u306b<em>C. elegans<\/em>\u3092\u7814\u7a76\u3059\u308b\u30b0\u30eb\u30fc\u30d7\u304c\u3042\u308a\u3001\u9694\u5e74\u306b\u96c6\u4f1a\u3092\u958b\u3044\u3066\u7814\u7a76\u767a\u8868\u3084\u4ea4\u6d41\u3092\u884c\u306a\u3063\u3066\u3044\u307e\u3059\u3002<em>C. elegans<\/em>\u306b\u95a2\u3059\u308b\u60c5\u5831\u3092\u96c6\u3081\u305f\u30b5\u30a4\u30c8\uff08Wormbase, Wormatlas\uff09\u3001\u30aa\u30f3\u30e9\u30a4\u30f3\u306e\u6559\u79d1\u66f8\uff08Wormbook\uff09\u3001\u5909\u7570\u4f53\u306e\u8490\u96c6\u3068\u914d\u5e03\u3092\u884c\u3046\u30bb\u30f3\u30bf\u30fc(CGC)\u3082\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306b\u3001\u7dda\u866b<em>C. elegans<\/em>\u306f\u512a\u308c\u305f\u300c\u30e2\u30c7\u30eb\u751f\u7269\u300d\u3068\u3057\u3066\u79d1\u5b66\u306b\u8ca2\u732e\u3057\u3066\u3044\u308b\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\uff08\uff12\uff09\u4f55\u306e\u305f\u3081\u306e\u7dda\u866b<em>C.elegans<\/em>\u7814\u7a76\u304b<\/h4>\n\n\n\n<p>\u4e16\u754c\u4e2d\u306e\u7814\u7a76\u8005\u306f\u3001\u4f55\u306e\u305f\u3081\u306b\u7dda\u866b<em>C. elegans<\/em>\u3092\u4f7f\u3063\u3066\u7814\u7a76\u3092\u3057\u3066\u3044\u308b\u306e\u3067\u3057\u3087\u3046\u304b\u3002\u305d\u308c\u306f\u3001\u300c\u751f\u547d\u3068\u306f\u4f55\u304b\u300d\u3068\u3044\u3046\u3001\u4eba\u985e\u306e\u3082\u3064\u6839\u672c\u7684\u306a\u8b0e\u306b\u3001\u81ea\u7136\u79d1\u5b66\u306e\u65b9\u6cd5\u3092\u4f7f\u3063\u3066\u7b54\u3048\u308b\u305f\u3081\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u53e4\u4ee3\u30ae\u30ea\u30b7\u30e3\u306e\u54f2\u5b66\u8005\u30a2\u30ea\u30b9\u30c8\u30c6\u30ec\u30b9\u306f\u3001\u300c\u751f\u547d\uff08\u30d7\u30b7\u30e5\u30b1\u30fc\uff09\u3068\u306f\u751f\u7269\u306e\u50cd\u304d\uff08\u6804\u990a\u6442\u53d6\u30fb\u611f\u899a\u30fb\u904b\u52d5\u30fb\u6b32\u6c42\u30fb\u7406\u6027\u306a\u3069\uff09\u3092\u3064\u304b\u3055\u3069\u308b\u539f\u7406\u3067\u3042\u308b\u300d\u3001\u3068\u8a00\u3044\u307e\u3057\u305f\u3002\u305d\u306e\u5f8c\u3001\u8fd1\u4e16\u306b\u306a\u3063\u3066\u300c\u4eee\u8aac\u3092\u7acb\u3066\u3066\u691c\u8a3c\u3059\u308b\u300d\u3068\u3044\u3046\u81ea\u7136\u79d1\u5b66\u306e\u65b9\u6cd5\u304c\u73fe\u308c\u3066\u3001\u751f\u547d\u306e\u7814\u7a76\u306f\u7740\u5b9f\u306b\u9032\u6b69\u3057\u300119\u4e16\u7d00\u306b\u306f\u7d30\u80de\u30fb\u9032\u5316\u30fb\u907a\u4f1d\u5b50\u3068\u3044\u3046\u5168\u751f\u7269\u306b\u5171\u901a\u306e\u57fa\u76e4\u304c\u767a\u898b\u3055\u308c\u308b\u306b\u81f3\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b20\u4e16\u7d00\u306b\u5165\u308b\u3068\u3001\u60c5\u5831\u3068\u30b7\u30b9\u30c6\u30e0\u3092\u30ad\u30fc\u30ef\u30fc\u30c9\u3068\u3057\u3066\u3001DNA\u306e\u907a\u4f1d\u60c5\u5831\u304b\u3089\u751f\u7269\u306e\u50cd\u304d\u304c\u3069\u306e\u3088\u3046\u306b\u751f\u3058\u308b\u304b\u3092\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u89e3\u660e\u3059\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002\u305d\u306e\u4e2d\u3067<em>C. elegans<\/em>\u306f\u767a\u751f\u3084\u884c\u52d5\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u660e\u3059\u308b\u305f\u3081\u306e\u7814\u7a76\u6750\u6599\u3068\u3057\u3066\u63a1\u7528\u3055\u308c\u3001\u4ed6\u306e\u5206\u91ce\u3082\u542b\u3081\u3066\u3001\u751f\u7269\u306e\u8b0e\u3092\u3044\u304f\u3064\u3082\u89e3\u660e\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u7dda\u866b\u3067\u6b63\u3057\u3044\u3053\u3068\u306e\u591a\u304f\u306f\u3001\u57fa\u672c\u7684\u306b\u30d2\u30c8\u3067\u3082\u6b63\u3057\u3044\u306e\u3067\u3059\u3002\u7dda\u866b<em>C. elegans<\/em>\u7814\u7a76\u306f\u4eca\u5f8c\u3082\u767a\u5c55\u3057\u3001\u751f\u7269\u306e\u7d20\u6674\u3089\u3057\u3055\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u76e3\u4fee\u8005<\/strong><br>\u6842\u3000\u52f2\u30001945\u5e74\u795e\u5948\u5ddd\u770c\u751f\u307e\u308c\u3001\u6771\u4eac\u5927\u5b66\u5927\u5b66\u9662\u535a\u58eb\u8ab2\u7a0b\u4fee\u4e86\u3002\u73fe\u5728\u3001\u56fd\u7acb\u907a\u4f1d\u5b66\u7814\u7a76\u6240\u540d\u8a89\u6559\u6388\u3001\u7dcf\u5408\u7814\u7a76\u5927\u5b66\u9662\u5927\u5b66\u540d\u8a89\u6559\u6388\u3002<\/p>\n\n\n\n<p class=\"has-text-align-right has-small-font-size\">\u00a92026 \u6842\u52f2\u300c1.\u3000\u7dda\u866b\u3068\u306f\u300d<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">CC BY<\/a><\/p>\n\n\n\n<p class=\"has-text-align-right\"><a href=\"#toc_container\" data-type=\"internal\" data-id=\"#toc_container\">\u76ee\u6b21\u30da\u30fc\u30b8\u3078\u2191<\/a><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div><\/section>\n\n\n\n<section id=\"section-2\" class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h3 class=\"wp-block-heading\">2.\u3000\u7dda\u866b\u306e\u4f53\u3068\u6027<\/h3>\n\n\n\n<h4 class=\"wp-block-heading\">\uff08\uff11\uff09\u7dda\u866b\u306e\u4f53<\/h4>\n\n\n\n<p>\u7dda\u866b\uff08<em>Caenorhabditis elegans<\/em>\uff09\u3068\u306f\u4e16\u754c\u4e2d\u306b\u751f\u606f\u3057\u3066\u3044\u308b\u5c0f\u3055\u306a\u751f\u7269\u3067\u3059\u3002\u4f53\u306f\u7b52\u72b6\u30671mm\u306e\u9577\u3055\u3057\u304b\u306a\u3044\u305f\u3081\u3001\u7814\u7a76\u3067\u6271\u3044\u3084\u3059\u3044\u3068\u3044\u3046\u5229\u70b9\u304c\u3042\u308a\u307e\u3059\u3002\u308f\u305a\u304b1\u5343\u5f31\u306e\u7d30\u80de\u3057\u304b\u306a\u3044\u3082\u306e\u306e\u3001\u795e\u7d4c\u7cfb\u3001\u7b4b\u8089\u7cfb\u3001\u6d88\u5316\u7cfb\u3001\u5916\u76ae\u7cfb\u3001\u751f\u6b96\u7cfb\u306e\u7d44\u7e54\u304c\u3042\u308a\u3001\u4f53\u304c\u900f\u660e\u3067\u3042\u308b\u305f\u3081\u3001\u5358\u7d14\u306a\u9855\u5fae\u93e1\u3067\u3053\u308c\u3089\u306e\u7d30\u80de\u3092\u89b3\u5bdf\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u795e\u7d4c\u7cfb\u306f302\u500b\u306e\u7d30\u80de\u304b\u3089\u306a\u308a\u3001\u305d\u306e\u5927\u90e8\u5206\u306f\u539f\u59cb\u7684\u306a\u8133\u306e\u3088\u3046\u306b\u982d\u306b\u96c6\u7d50\u3057\u3066\u3044\u307e\u3059\u3002\u982d\u304b\u3089\u5c3e\u307e\u3067\u3001\u8179\u3068\u80cc\u306b\u6cbf\u3063\u3066\u904b\u52d5\u795e\u7d4c\u7cfb\u304c\u3064\u306a\u304c\u3063\u3066\u3044\u307e\u3059\u3002\u904b\u52d5\u7528\u306e\u7b4b\u8089\u306f\u7b52\u72b6\u306e\u4f53\u306e\u5185\u9762\u306b4\u5206\u5186\u306e\u3088\u3046\u306b\u982d\u304b\u3089\u5c3e\u307e\u3067\u4e00\u69d8\u306b\u3064\u3044\u3066\u3044\u307e\u3059\u3002\u53e3\u306b\u3042\u305f\u308b\u7b4b\u8089\u8cea\u306e\u300c\u54bd\u982d\u300d\u3067\u7d30\u83cc\u3092\u7815\u3044\u3066\u98df\u3079\u3001\u4f53\u9577\u306e\u307b\u3068\u3093\u3069\u3092\u5360\u3081\u308b\u8178\u3067\u6d88\u5316\u3057\u307e\u3059\u3002\u5c3e\u306b\u306f\u809b\u9580\u304c\u3042\u308a\u3001\u6392\u51fa\u3092\u4fc3\u3059\u7b4b\u8089\u3082\u3064\u3044\u3066\u3044\u307e\u3059\u3002\u4f53\u306e\u5916\u9762\u306f\u76ae\u7d30\u80de\u304c\u5206\u6ccc\u3059\u308b\u30bf\u30f3\u30d1\u30af\u304b\u3089\u69cb\u6210\u3055\u308c\u308b\u30af\u30c1\u30af\u30e9\u3068\u3044\u3046\u6bbb\u3067\u8986\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u7d44\u7e54\u306f\u30d2\u30c8\u3068\u6bd4\u3079\u308b\u3068\u5c0f\u3055\u3044\u3082\u306e\u306e\u3001\u305d\u306e\u57fa\u672c\u7684\u306a\u6a5f\u80fd\u3068\u69cb\u6210\u69d8\u5f0f\u306f\u5171\u901a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\uff08\uff12\uff09\u7dda\u866b\u306e\u6027<\/h4>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p>\u7dda\u866b\u306b\u306f\u96cc\u96c4\u540c\u4f53\u3068\u96c4\u30682\u3064\u306e\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u96cc\u96c4\u540c\u4f53\u306b\u306f\u7523\u5375\u3068\u4ea4\u5c3e\u306e\u305f\u3081\u306e\u5916\u9670\u90e8\u304c\u3042\u308a\u3001\u4f53\u5185\u306b\u306f\u5375\u5b50\u3068\u7cbe\u5b50\u3092\u4f5c\u308b\u751f\u6b96\u817a\u304c\u3042\u308a\u307e\u3059\u3002\u96c4\u306f\u5c3e\u306b\u4ea4\u5c3e\u306e\u305f\u3081\u306e\u30d2\u30ec\u304c\u3042\u308a\u3001\u7cbe\u5b50\u3092\u4f5c\u308b\u751f\u6b96\u817a\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u96cc\u96c4\u540c\u4f53\u306e\u5834\u5408\u3001\u6210\u866b\u306b\u306a\u308b\u5bf8\u524d\u306b\u7cbe\u5b50\u304c\u4f5c\u3089\u308c\u3001\u751f\u6b96\u817a\u306b\u4fdd\u5b58\u3055\u308c\u307e\u3059\u3002\u6210\u866b\u306b\u306a\u3063\u305f\u5f8c\u3001\u3088\u308a\u5927\u304d\u3044\u5375\u5b50\u304c\u4f5c\u3089\u308c\u3001\u4fdd\u5b58\u3055\u308c\u305f\u7cbe\u5b50\u3068\u3001\u307e\u305f\u306f\u4ea4\u5c3e\u304b\u3089\u306e\u7cbe\u5b50\u3068\u53d7\u7cbe\u3057\u307e\u3059\u3002<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"451\" height=\"277\" src=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/06\/ecf89b214f8587a6a2a28cc774e2732a.png\" alt=\"\" class=\"wp-image-1177\" srcset=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/06\/ecf89b214f8587a6a2a28cc774e2732a.png 451w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/06\/ecf89b214f8587a6a2a28cc774e2732a-300x184.png 300w\" sizes=\"(max-width: 451px) 100vw, 451px\" \/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<p>\u96cc\u96c4\u540c\u4f53\u306f\u6210\u866b\u306b\u81f3\u308b\u307e\u3067\u306b\u4f5c\u308a\u3060\u3057\u305f\u7cbe\u5b50\u306b\u3088\u3063\u3066\u7d04300\u306e\u5b50\u3092\u7523\u307f\u307e\u3059\u304c\u3001\u4ea4\u5c3e\u3057\u305f\u5834\u5408\u306f\u7d041000\u306e\u5b50\u3092\u7523\u3080\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u7dda\u866b\u306e\u6027\u5225\u306fX\u67d3\u8272\u4f53\u306e\u6570\u306b\u3088\u3063\u3066\u6c7a\u3081\u3089\u308c\u3001X\u67d3\u8272\u4f53\u304c2\u3064\u306e\u5834\u5408\u306f\u96cc\u96c4\u540c\u4f53\u30011\u3064\u306e\u5834\u5408\u306f\u96c4\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3088\u3063\u3066\u3001\u96cc\u96c4\u540c\u4f53\u304c\u4f5c\u308b\u7cbe\u5b50\u306f\u5168\u3066X\u3092\u6301\u3061\u3001\u96cc\u96c4\u540c\u4f53\u306e\u5b50\u3057\u304b\u7523\u307f\u307e\u305b\u3093\u3002\u96c4\u304c\u4f5c\u308b\u7cbe\u5b50\u306e\u3046\u3061\u534a\u5206\u306fX\u67d3\u8272\u4f53\u3092\u6301\u3061\u3001\u3082\u3046\u534a\u5206\u306f\u6027\u67d3\u8272\u4f53\u3092\u6301\u305f\u306a\u3044\u305f\u3081\u3001\u4ea4\u5c3e\u3057\u305f\u500b\u4f53\u306e\u5b50\u306f\u96cc\u96c4\u540c\u4f53\u3068\u96c4\u304c1\uff1a1\u306e\u5272\u5408\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u53c2\u8003\u8cc7\u6599<\/strong><br>1) Ann K.Corsi\u3089\u8457 \u300cA Transparent window into biology: A primer on Caenorhabditis elegans\u300d\u30012015\u5e74 WormBook, ed. The <em>C. elegans<\/em> Research Community, WormBook, doi\/10.1895\/wormbook.1.177.1, http:\/\/www.wormbook.org.<\/p>\n\n\n\n<p><strong>\u76e3\u4fee\u8005<\/strong><br>\u30b9\u30ce\u30fc\u30fb\u30a2\u30f3\u30c9\u30ea\u30e5\u30fc\u3000\u30d6\u30ea\u30c6\u30a3\u30c3\u30b7\u30e5\u30b3\u30ed\u30f3\u30d3\u30a2\u5927\u5b66\u5927\u5b66\u9662\u7d30\u80de\u30fb\u767a\u751f\u751f\u7269\u5b66\u30d7\u30ed\u30b0\u30e9\u30e0\u6240\u5c5e\u3002\u73fe\u5728\u3001\u535a\u58eb\u8ab2\u7a0b\u5b66\u751f\u3068\u3057\u3066\u6c34\u5143\u516c\u5927\u7814\u7a76\u5ba4\u306b\u6240\u5c5e\u3057\u3001\u7dda\u866b\u306e\u30b7\u30ca\u30d7\u30b9\u30d1\u30bf\u30fc\u30f3\u5f62\u6210\u306e\u7814\u7a76\u3092\u3057\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p>\u6c34\u5143\u3000\u516c\u5927\u3000\u795e\u6238\u5927\u5b66\u5927\u5b66\u9662\u535a\u58eb\u8ab2\u7a0b\u4fee\u4e86\u3002\u73fe\u5728\u3001\u30d6\u30ea\u30c6\u30a3\u30c3\u30b7\u30e5\u30b3\u30ed\u30f3\u30d3\u30a2\u5927\u5b66\u51c6\u6559\u6388\u3068\u3057\u3066\u30b7\u30ca\u30d7\u30b9\u306e\u30d1\u30bf\u30fc\u30f3\u5f62\u6210\u3084\u795e\u7d4c\u767a\u751f\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u306e\u7814\u7a76\u3092\u3057\u3066\u3044\u308b\u3002\u3002<\/p>\n\n\n\n<p class=\"has-text-align-right has-small-font-size\">\u00a92026 \u30b9\u30ce\u30fc\u30fb\u30a2\u30f3\u30c9\u30ea\u30e5\u30fc\u300c2.\u3000\u7dda\u866b\u306e\u4f53\u3068\u6027\u300d<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">CC BY<\/a><\/p>\n\n\n\n<p class=\"has-text-align-right\"><a href=\"#toc_container\" data-type=\"internal\" data-id=\"#toc_container\">\u76ee\u6b21\u30da\u30fc\u30b8\u3078\u2191<\/a><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div><\/section>\n\n\n\n<section id=\"section-3\" class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h3 class=\"wp-block-heading\">3.\u3000\u7dda\u866b\u7814\u7a76\u306e\u6b74\u53f2<\/h3>\n\n\n\n<h3 class=\"wp-block-heading\">\uff08\uff11\uff09\u59cb\u307e\u308a\u306f\u30b7\u30c9\u30cb\u30fc\u30fb\u30d6\u30ec\u30ca\u30fc<\/h3>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"557\" height=\"642\" src=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2026\/02\/3cbf5c890de7a056467a97a4574a8031-1.jpg\" alt=\"\" class=\"wp-image-1287\" srcset=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2026\/02\/3cbf5c890de7a056467a97a4574a8031-1.jpg 557w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2026\/02\/3cbf5c890de7a056467a97a4574a8031-1-260x300.jpg 260w\" sizes=\"(max-width: 557px) 100vw, 557px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<p>\u30b7\u30c9\u30cb\u30fc\u30fb\u30d6\u30ec\u30ca\u30fc\u306f\u300120\u4e16\u7d00\u3092\u4ee3\u8868\u3059\u308b\u5206\u5b50\u751f\u7269\u5b66\u8005\u3067\u3059\u3002\u5f7c\u306f\u30011950\u5e74\u4ee3\u306b\u3001DNA\uff12\u91cd\u87ba\u65cb\u69cb\u9020\u3092\u89e3\u660e\u3057\u305f\u3053\u3068\u3067\u77e5\u3089\u308c\u308b\u30d5\u30e9\u30f3\u30b7\u30b9\u30fb\u30af\u30ea\u30c3\u30af\u3089\u3068\u3068\u3082\u306b\u3001\u907a\u4f1d\u6697\u53f7\u306e\u89e3\u8aad\u306b\u53d6\u308a\u7d44\u307f\u3001\u5927\u8178\u83cc\u3084\u30d0\u30af\u30c6\u30ea\u30aa\u30d5\u30a1\u30fc\u30b8\u306a\u3069\u306e\u5358\u7d30\u80de\u751f\u7269\u3084\u30a6\u30a4\u30eb\u30b9\u3092\u7814\u7a76\u5bfe\u8c61\u3068\u3057\u3066\u3001\u907a\u4f1d\u5b50\u304b\u3089\u30bf\u30f3\u30d1\u30af\u8cea\u3078\u3068\u907a\u4f1d\u60c5\u5831\u304c\u4f1d\u9054\u3055\u308c\u308b\u300c\u30bb\u30f3\u30c8\u30e9\u30eb\u30c9\u30b0\u30de\u300d\u3092\u78ba\u7acb\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u305d\u306e\u5f8c\u3001\u30d6\u30ec\u30ca\u30fc\u306f\u3088\u308a\u8907\u96d1\u306a\u751f\u547d\u73fe\u8c61\u3092\u5bfe\u8c61\u3068\u3057\u305f\u65b0\u3057\u3044\u751f\u7269\u5b66\u306e\u5275\u751f\u3092\u76ee\u6307\u3057\u307e\u3057\u305f\u3002\u5f53\u6642\u3001\u5f7c\u306f\u3001\u89e3\u660e\u3059\u3079\u304d\u8ab2\u984c\u3068\u3057\u3066\u3001\u300c\u591a\u7d30\u80de\u751f\u7269\u306e\u4f53\u3092\u5f62\u3065\u304f\u308b\u3057\u304f\u307f\u300d\u3084\u300c\u795e\u7d4c\u7cfb\u304c\u60c5\u5831\u3092\u51e6\u7406\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u300d\u306a\u3069\u3092\u8003\u3048\u3066\u3044\u307e\u3057\u305f\u3002\u3053\u3046\u3057\u305f\u8ab2\u984c\u3092\u89e3\u660e\u3059\u308b\u305f\u3081\u306e\u591a\u7d30\u80de\u751f\u7269\u30e2\u30c7\u30eb\u306b\u306f\u4f55\u3092\u4f7f\u3048\u3070\u3088\u3044\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n<\/div>\n<\/div>\n\n\n\n<p>\u300c\u795e\u7d4c\u7cfb\u3067\u306e\u60c5\u5831\u51e6\u7406\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u306b\u306f\u3001\u795e\u7d4c\u7d30\u80de\u304c\u3069\u306e\u3088\u3046\u306b\u63a5\u7d9a\u3057\u3066\u3044\u308b\u306e\u304b\u3001\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002\u795e\u7d4c\u7d30\u80de\u306e\u63a5\u7d9a\u69d8\u5f0f\u3092\u89e3\u660e\u3059\u308b\u306b\u306f\u3001\u96fb\u5b50\u9855\u5fae\u93e1\u3092\u4f7f\u3063\u3066\u5fae\u7d30\u306a\u69cb\u9020\u3092\u89b3\u5bdf\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002\u96fb\u5b50\u9855\u5fae\u93e1\u3067\u89b3\u5bdf\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u5bfe\u8c61\u306f\u3001\u975e\u5e38\u306b\u5c0f\u3055\u3044\u3002\u300d\u3053\u3046\u3057\u305f\u3053\u3068\u304b\u3089\u3001\u30d6\u30ec\u30ca\u30fc\u306f\u65b0\u305f\u306b\u53d6\u308a\u7d44\u3080\u30e2\u30c7\u30eb\u751f\u7269\u306f\u3001\u300c\u907a\u4f1d\u5b66\u7684\u89e3\u6790\u304c\u53ef\u80fd\u300d\u3067\u3001\u300c\u4e16\u4ee3\u6642\u9593\u304c\u77ed\u304f\u300d\u3001\u300c\u7814\u7a76\u5ba4\u74b0\u5883\u3067\u5bb9\u6613\u306b\u98fc\u80b2\u304c\u3067\u304d\u308b\u300d\u3068\u3044\u3046\u3053\u3068\u306b\u52a0\u3048\u3066\u3001\u300c\u4f53\u304c\u5c0f\u3055\u3044\u300d\u3068\u3044\u3046\u6027\u8cea\u3092\u5099\u3048\u3066\u3044\u308b\u3079\u304d\u3067\u3042\u308b\u3068\u8003\u3048\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3053\u3046\u3057\u305f\u6027\u8cea\u3092\u5099\u3048\u305f\u751f\u7269\u3068\u3057\u3066\u3001\u571f\u58cc\u306b\u4f4f\u3080\u7dda\u866b\u306b\u6ce8\u76ee\u3057\u3001<em>Caenorhabditis elegans<\/em> (\u4f53\u95771mm\uff09\u3092\u65b0\u305f\u306a\u30e2\u30c7\u30eb\u751f\u7269\u3068\u3057\u3066\u4f4d\u7f6e\u4ed8\u3051\u3001\u7814\u7a76\u3092\u958b\u59cb\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\uff08\uff12\uff09\u795e\u7d4c\u306e\u914d\u7dda\u56f3\u3092\u6c7a\u3081\u308b<\/h3>\n\n\n\n<p>\u7dda\u866b\u306f\u3001\u5168\u8eab\u306e\u795e\u7d4c\u304c\u3069\u3053\u3067\u3069\u306e\u3088\u3046\u306b\u63a5\u7d9a\u3057\u3066\u3044\u308b\u306e\u304b\u3068\u3044\u3046\u3001\u3044\u308f\u3070\u300c\u914d\u7dda\u56f3\u300d\u304c\u521d\u3081\u3066\u5b8c\u5168\u306b\u660e\u3089\u304b\u306b\u3055\u308c\u305f\u751f\u7269\u3067\u3059\u3002\u3053\u306e\u6b74\u53f2\u7684\u306a\u5049\u696d\u3092\u6210\u3057\u9042\u3052\u305f\u4e2d\u5fc3\u4eba\u7269\u3068\u3057\u3066\u3001\u30b8\u30e7\u30f3\u30fb\u30db\u30ef\u30a4\u30c8\u3068\u30cb\u30b3\u30eb\u30fb\u30c8\u30e0\u30bd\u30f3\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u3002\u5f7c\u3089\u306f\u30d6\u30ec\u30ca\u30fc\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306b\u52a0\u308f\u308a\u3001\u795e\u7d4c\u914d\u7dda\u56f3\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306b\u53d6\u308a\u7d44\u307f\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p>\u3053\u306e\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3067\u306f\u3001\u7dda\u866b\u3092\u304d\u308f\u3081\u3066\u8584\u3044\u5207\u7247\u306b\u30b9\u30e9\u30a4\u30b9\u3057\u30011\u679a\u305a\u3064\u96fb\u5b50\u9855\u5fae\u93e1\u3067\u64ae\u50cf\u3057\u3066\u3001\u3069\u306e\u795e\u7d4c\u7d30\u80de\u3068\u3069\u306e\u795e\u7d4c\u7d30\u80de\u304c\u3069\u3053\u3067\u3069\u306e\u3088\u3046\u306b\u63a5\u7d9a\u3057\u3066\u3044\u308b\u304b\u3092\u89e3\u660e\u3057\u3066\u3044\u304d\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u305f\u3068\u3048\u3066\u8a00\u3048\u3070\u3001\u4e00\u672c\u306e\u30ad\u30e5\u30a6\u30ea\u30922\u4e07\u679a\u306e\u8f2a\u5207\u308a\u306b\u3057\u3001\u5168\u3066\u306e\u8f2a\u5207\u308a\u65ad\u9762\u306e\u5199\u771f\u3092\u64ae\u3063\u3066\u30012\u4e07\u679a\u306e\u5199\u771f\u304c\u7a7a\u9593\u7684\u306b\u3064\u306a\u304c\u308b\u3088\u3046\u306b\u4f4d\u7f6e\u3092\u5408\u308f\u305b\u306a\u304c\u3089\u3001\u30ad\u30e5\u30a6\u30ea\u5185\u90e8\u306e\u5fae\u7d30\u306a\u69cb\u9020\u3092\u89b3\u5bdf\u3059\u308b\u3001\u3068\u3044\u3063\u305f\u975e\u5e38\u306b\u6c17\u304c\u9060\u304f\u306a\u308b\u3088\u3046\u306a\u4f5c\u696d\u3067\u3059\u3002<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"657\" src=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2026\/02\/3-2-1024x657.jpg\" alt=\"\" class=\"wp-image-1290\" srcset=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2026\/02\/3-2-1024x657.jpg 1024w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2026\/02\/3-2-300x192.jpg 300w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2026\/02\/3-2-768x493.jpg 768w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2026\/02\/3-2-1536x985.jpg 1536w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2026\/02\/3-2-670x430.jpg 670w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2026\/02\/3-2.jpg 1712w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<p>\u30c8\u30e0\u30bd\u30f3\u306f\u96fb\u5b50\u9855\u5fae\u93e1\u306e\u30b9\u30da\u30b7\u30e3\u30ea\u30b9\u30c8\u3001\u30db\u30ef\u30a4\u30c8\u306f\u30a8\u30f3\u30b8\u30cb\u30a2\u3067\u3042\u3063\u305f\u3053\u3068\u304b\u3089\u3001\u5f7c\u3089\u306e\u5c02\u9580\u77e5\u8b58\u304c\u3053\u306e\u5049\u696d\u306e\u9054\u6210\u306b\u5927\u304d\u304f\u5f79\u7acb\u3061\u307e\u3057\u305f\u3002\u3053\u306e\u7814\u7a76\u4e8b\u4f8b\u306f\u3001\u4eca\u3067\u8a00\u3046\u7570\u5206\u91ce\u878d\u5408\u306b\u3088\u308b\u30d6\u30ec\u30a4\u30af\u30b9\u30eb\u30fc\u3068\u8a00\u3048\u307e\u3059\u3002\u30d6\u30ec\u30ca\u30fc\u306f\u3001\u306e\u3061\u306b\u300c\u79d1\u5b66\u3092\u5207\u308a\u62d3\u304f\u306e\u306f\u3001\u3044\u3064\u3082\u3001\u5206\u91ce\u5916\u304b\u3089\u53c2\u5165\u3057\u305f\u4eba\u305f\u3061\u3060\uff08I\u2019ve always found that the best people to push science forward are those who come from outside it)\u300d\u3068\u3044\u3046\u8a00\u8449\u3092\u6b8b\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\uff08\uff13\uff09\u7d30\u80de\u7cfb\u8b5c\uff08\u7d30\u80de\u306e\u5bb6\u7cfb\u56f3\uff09\u3092\u6c7a\u3081\u308b<\/h3>\n\n\n\n<p>\u7dda\u866b\u306f\u3001\u53d7\u7cbe\u5375\u304b\u3089\u6210\u866b\u306b\u81f3\u308b\u307e\u3067\u306e\u3059\u3079\u3066\u306e\u7d30\u80de\u5206\u88c2\u304c\u660e\u3089\u304b\u306b\u3055\u308c\u3066\u3044\u308b\u552f\u4e00\u306e\u591a\u7d30\u80de\u751f\u7269\u3067\u3059\uff082025\u5e74\u73fe\u5728\uff09\u3002\u53d7\u7cbe\u5375\u304b\u3089\u3069\u306e\u3088\u3046\u306a\u7d30\u80de\u5206\u88c2\u304c\u3001\u3044\u3064\u3001\u3069\u3053\u3067\u8d77\u3053\u308a\u3001\u3069\u306e\u7d30\u80de\u304c\u6700\u7d42\u7684\u306b\u3069\u306e\u3088\u3046\u306a\u7d30\u80de\uff08\u795e\u7d4c\u7d30\u80de\u3001\u7b4b\u7d30\u80de\u3001\u751f\u6b96\u7d30\u80de\u306a\u3069\uff09\u306b\u5206\u5316\u3059\u308b\u306e\u304b\u3001\u3068\u3044\u3046\u3044\u308f\u3070\u300c\u7d30\u80de\u306e\u5bb6\u7cfb\u56f3\u300d\u304c\u660e\u3089\u304b\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u795e\u7d4c\u306e\u914d\u7dda\u56f3\u3092\u6c7a\u5b9a\u3057\u305f\u7814\u7a76\u3068\u540c\u3058\u304f\u3001\u81a8\u5927\u306a\u6642\u9593\u3068\u52b4\u529b\u306e\u4e0a\u306b\u7d50\u5b9f\u3057\u305f\u5049\u696d\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u7814\u7a76\u304b\u3089\u3001\u7d30\u80de\u306e\u5bb6\u7cfb\u56f3\u306f\u3001\u500b\u4f53\u9593\u3067\u4e0d\u5909\u3067\u3042\u308a\u3001\u300c\u7dda\u866b\u306e\u6210\u866b\u306f\u3001959\u500b\u306e\u7d30\u80de\u304b\u3089\u69cb\u6210\u3055\u308c\u3066\u3044\u308b\u300d\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u306e\u5049\u696d\u3092\u6210\u3057\u9042\u3052\u305f\u4e2d\u5fc3\u4eba\u7269\u306f\u3001\u30b8\u30e7\u30f3\u30fb\u30b5\u30eb\u30b9\u30c8\u30f3\u3068\u30dc\u30d6\u30fb\u30db\u30ed\u30d3\u30c3\u30c4\u3067\u3059\u3002\u5f7c\u3089\u306f\u3001\u751f\u304d\u305f\u7dda\u866b\u3092\u9855\u5fae\u93e1\u4e0b\u3067\u76f4\u63a5\u89b3\u5bdf\u3057\u3001\u3059\u3079\u3066\u306e\u7d30\u80de\u306e\u7d30\u80de\u5206\u88c2\u3092\u8ffd\u8de1\u3057\u307e\u3057\u305f\u3002\u7279\u306b\u30b5\u30eb\u30b9\u30c8\u30f3\u306f\u3001\u7dda\u866b\u80da\uff08\u53d7\u7cbe\u5375\uff09\u304c\u5b75\u5316\u3059\u308b\u307e\u3067\u306e\u9593\u306b558\u500b\u306e\u7d30\u80de\u304c\u751f\u3058\u308b\u3053\u3068\u3092\u7a81\u304d\u6b62\u3081\u307e\u3057\u305f\uff08\u7dda\u866b\u306f\u5b75\u5316\u5f8c\u3001\u5e7c\u866b\u306e\u6bb5\u968e\u3067\u7d30\u80de\u5206\u88c2\u3092\u7e70\u308a\u8fd4\u3057\u3001\u6210\u866b\u307e\u3067\u306b959\u500b\u306e\u7d30\u80de\u3092\u3082\u3064\u3088\u3046\u306b\u306a\u308a\u307e\u3059\uff09\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u7dda\u866b\u80da\u306e\u89b3\u5bdf\u5b9f\u9a13\u3092\u4f8b\u3048\u308b\u3068\u3059\u308b\u306a\u3089\u3070\u3001\u3053\u306d\u3066\u4e38\u3081\u305f1\u3064\u306e\u30d1\u30f3\u751f\u5730\u306b\u6b21\u3005\u3068\u4ed5\u5207\u308a\u304c\u751f\u3058\u3001\u5168\u4f53\u306e\u5927\u304d\u3055\u3092\u5909\u3048\u305a\u306b558\u500b\u306e\u533a\u753b\u306b\u4ed5\u5207\u3089\u308c\u3066\u3044\u304f\u69d8\u5b50\u3092\u89b3\u5bdf\u3057\u3066\u3001\u3069\u306e\u533a\u753b\u304c\u3069\u3046\u3044\u3063\u305f\u7cfb\u8b5c\u304b\u3089\u751f\u307e\u308c\u305f\u304b\u3092\u5b8c\u5168\u306b\u8ffd\u8de1\u3059\u308b\u3001\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u3055\u3089\u306b\u5384\u4ecb\u306a\u3053\u3068\u306b\u3001\u3053\u306e\u30d1\u30f3\u751f\u5730\u306f\u3001\u4e00\u5b9a\u306e\u6642\u9593\u304c\u7d4c\u3064\u3068\uff08\u7b4b\u7d30\u80de\u304c\u751f\u3058\u3066\u5206\u5316\u304c\u9032\u3080\u3068\uff09\u3001\u81ea\u5f8b\u7684\u306b\u4f53\u52d5\u3092\u59cb\u3081\u3066\u3057\u307e\u3044\u307e\u3059\uff01<\/p>\n\n\n\n<p>\u30b5\u30eb\u30b9\u30c8\u30f3\u306f\u3001\u7d30\u80de\u7cfb\u8b5c\u3092\u5831\u544a\u3057\u305f\u8ad6\u6587\u306e\u4e2d\u3067\u3001\u300c\u308f\u308c\u308f\u308c\u304c\u5831\u544a\u3057\u305f\u7d30\u80de\u7cfb\u8b5c\u306b\u30a8\u30e9\u30fc\u304c\u306a\u3044\u3068\u8003\u3048\u308b\u306e\u306f\u671b\u307f\u3059\u304e\u3067\u3042\u308d\u3046\u300d\u3068\u81ea\u3089\u306e\u4ed5\u4e8b\u3078\u306e\u8b66\u9418\u3092\u66f8\u304d\u6b8b\u3057\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u30b5\u30eb\u30b9\u30c8\u30f3\u304c\u6c7a\u5b9a\u3057\u305f\u7d30\u80de\u7cfb\u8b5c\u306b\u5bfe\u3059\u308b\u30db\u30ed\u30d3\u30c3\u30c4\u306e\u4fe1\u983c\u306f\u539a\u304f\u3001\u306e\u3061\u306b\u3001\u300c\u30b8\u30e7\u30f3\u304c\u9593\u9055\u3048\u308b\u3053\u3068\u306f\u3042\u308a\u3048\u306a\u3044\u300d\u3068\u3044\u3046\u8a00\u8449\u3092\u6b8b\u3057\u3066\u3044\u307e\u3059\u3002\u5b9f\u969b\u306b\u3001\u7d30\u80de\u7cfb\u8b5c\u306e\u5b8c\u5168\u306a\u8a18\u8ff0\uff081983\u5e74\uff09\u304b\u308940\u5e74\u4ee5\u4e0a\u304c\u7d4c\u3063\u305f\u73fe\u5728\u306b\u304a\u3044\u3066\u3082\u3001\u7dda\u866b\u306e\u7d30\u80de\u7cfb\u8b5c\u306f\u5f53\u6642\u306e\u59ff\u304b\u3089\u66f8\u304d\u5909\u308f\u3063\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"has-text-align-left\"><strong>\u53c2\u8003\u8cc7\u6599<\/strong><br>1) Errol C. Friedberg\u8457 \u300cSYDNEY BRENNER A Biography\u300d\u30012010\u5e74 Cold Spring Harbor Laboratory Press 2) John G. White\u8457 \u300cGetting into the mind of a worm\u2014a personal view\u300d\u30012013\u5e74\u3000WormBook, ed. The <em>C. elegans<\/em> Research Community, WormBook, doi\/10.1895\/wormbook.1.158.1, http:\/\/www.wormbook.org.<\/p>\n\n\n\n<p class=\"has-text-align-left\"><strong>\u76e3\u4fee\u8005<\/strong><br>\u4e2d\u91ce\u3000\u4fca\u8a69\u30001976\u5e74\u6771\u4eac\u90fd\u751f\u307e\u308c\u3002\u30de\u30b5\u30c1\u30e5\u30fc\u30bb\u30c3\u30c4\u5de5\u79d1\u5927\u5b66\u5927\u5b66\u9662\u535a\u58eb\u8ab2\u7a0b\u4fee\u4e86\u3002\u73fe\u5728\u3001\u540d\u53e4\u5c4b\u5927\u5b66\u8b1b\u5e2b\u3068\u3057\u3066\u7dda\u866b\u306e\u767a\u751f\u30fb\u4f11\u7720\u30fb\u884c\u52d5\u30fb\u610f\u601d\u6c7a\u5b9a\u306e\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p class=\"has-text-align-right has-small-font-size\">\u00a92026 \u866b\u306e\u96c6\u3044\uff08\u7dda\u866b\u7814\u7a76\u8005\u30b3\u30df\u30e5\u30cb\u30c6\u30a3\uff09\u300c3.\u3000\u7dda\u866b\u7814\u7a76\u306e\u6b74\u53f2\u300d<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">CC BY<\/a><\/p>\n\n\n\n<p class=\"has-text-align-right\"><a href=\"#toc_container\" data-type=\"internal\" data-id=\"#toc_container\">\u76ee\u6b21\u30da\u30fc\u30b8\u3078\u2191<\/a><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div><\/section>\n\n\n\n<section id=\"section-4\" class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h3 class=\"wp-block-heading\">4.\u3000\u30b2\u30ce\u30e0\u30fb\u907a\u4f1d\u5b50<\/h3>\n\n\n\n<p>\u6e96\u5099\u4e2d<\/p>\n\n\n\n<p class=\"has-text-align-right\"><a href=\"#toc_container\" data-type=\"internal\" data-id=\"#toc_container\">\u76ee\u6b21\u30da\u30fc\u30b8\u3078\u2191<\/a><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div><\/section>\n\n\n\n<section id=\"section-5\" class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h3 class=\"wp-block-heading\">5.\u3000\u7dda\u866b\u306e\u7814\u7a76\u3068\u30ce\u30fc\u30d9\u30eb\u8cde<\/h3>\n\n\n\n<h4 class=\"wp-block-heading\">\uff08\uff11\uff09\u7dda\u866b\u306e\u57fa\u790e\u7814\u7a76\uff1a\u30d6\u30ec\u30ca\u30fc\u3001\u30b5\u30eb\u30b9\u30c8\u30f3\u3001\u30db\u30fc\u30d3\u30c3\u30c4<\/h4>\n\n\n\n<p>\u7dda\u866b<em>C. elegans<\/em>\u306b\u3064\u3044\u3066\u3001\u521d\u3081\u3066\u57fa\u790e\u7684\u306a\u7814\u7a76\u3092\u884c\u3063\u305f\u306e\u306f\u30a4\u30ae\u30ea\u30b9\u306e<strong>\u30b7\u30c9\u30cb\u30fc\u30fb\u30d6\u30ec\u30ca\u30fc<\/strong>\uff08S. Brenner\uff09\u3067\u30011960\u5e74\u4ee3\u306e\u3053\u3068\u3067\u3057\u305f\u3002\u8457\u540d\u306a\u5206\u5b50\u751f\u7269\u5b66\u8005\u3067\u3042\u3063\u305f\u30d6\u30ec\u30ca\u30fc\u306f\u3001\u52d5\u7269\u306e\u767a\u751f\u3084\u795e\u7d4c\u7cfb\u306e\u89e3\u6790\u306b\u3075\u3055\u308f\u3057\u3044\u52d5\u7269\u3068\u3057\u3066\u3001\u7dda\u5f62\u52d5\u7269\u9580\u306e\u52d5\u7269\u3067\u3042\u308b<strong>\u7dda\u866b<\/strong>\u304c\u826f\u3044\u3068\u8003\u3048\u3001\u591a\u6570\u306e\u7dda\u866b\u3092\u98fc\u80b2\u89b3\u5bdf\u3057\u305f\u7d50\u679c\u3001<em><strong>C. elegans<\/strong><\/em>\u3092\u9078\u3073\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u30d6\u30ec\u30ca\u30fc\u306f\u3001\u307e\u305a\u5909\u7570\u8a98\u5c0e\u5264EMS\u3092\u7528\u3044\u3066\u306a\u3093\u3089\u304b\u306e\u7570\u5e38\u3092\u793a\u3059\u5909\u7570\u4f53\u3092\u591a\u6570\u5206\u96e2\u3057\u3001\u305d\u308c\u3089\u3092\u7528\u3044\u3066\u907a\u4f1d\u5b50\u5730\u56f3\u3092\u4f5c\u6210\u3057\u307e\u3057\u305f\uff08<strong>\u7dda\u866b\u907a\u4f1d\u5b66\u306e\u78ba\u7acb<\/strong>\u30011974\u5e74\u8ad6\u6587\u767a\u8868\uff09\u3002\u3064\u304e\u306b\u3001\u4f53\u7d30\u80de\u306e\u7d043\u5206\u306e1\u3092\u5360\u3081\u308b\u795e\u7d4c\u7d30\u80de\u304b\u3089\u306a\u308b\u795e\u7d4c\u7cfb\u306e\u5fae\u7d30\u69cb\u9020\u3092\u30db\u30ef\u30a4\u30c8\u3089\u3068\u5171\u306b\u89e3\u6790\u3057\u307e\u3057\u305f\uff081986\u5e74\u8ad6\u6587\u767a\u8868\uff09\u3002\u3055\u3089\u306b\u3001\u30a4\u30ae\u30ea\u30b9\u4eba\u306e\u30b5\u30eb\u30b9\u30c8\u30f3\uff08J. E. Sulston\uff09\u3001\u30a2\u30e1\u30ea\u30ab\u4eba\u306e\u30db\u30ed\u30d3\u30c3\u30c4\uff08H. R. Horvitz\uff09\u3068\u5171\u306b<em>C. elegans<\/em>\u306e\u5168\u7d30\u80de\u306e\u751f\u6210\u904e\u7a0b\uff08<strong>\u7d30\u80de\u7cfb\u8b5c<\/strong>\uff09\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\uff081977\u5e74\u30011983\u5e74\u8ad6\u6587\u767a\u8868\uff09\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u696d\u7e3e\u306b\u5bfe\u3057\u3066\u30012002\u5e74\u4e0a\u8a183\u4eba\u306b\u30ce\u30fc\u30d9\u30eb\u751f\u7406\u5b66\u30fb\u533b\u5b66\u8cde\u304c\u6388\u4e0e\u3055\u308c\u307e\u3057\u305f\uff08\u300c\u5668\u5b98\u306e\u767a\u751f\u53ca\u3073\u30d7\u30ed\u30b0\u30e9\u30e0\u7d30\u80de\u6b7b\u306e\u907a\u4f1d\u7684\u5236\u5fa1\u306b\u95a2\u3059\u308b\u767a\u898b\u300d\uff09\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" width=\"498\" height=\"230\" src=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2026\/02\/bf4d083580f5c16786d9db2daaa5da6f.png\" alt=\"\" class=\"wp-image-1291\" style=\"width:693px;height:auto\" srcset=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2026\/02\/bf4d083580f5c16786d9db2daaa5da6f.png 498w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2026\/02\/bf4d083580f5c16786d9db2daaa5da6f-300x139.png 300w\" sizes=\"(max-width: 498px) 100vw, 498px\" \/><\/figure>\n<\/div>\n\n\n<h4 class=\"wp-block-heading\">\uff08\uff12\uff09RNA\u5e72\u6e09\u306e\u767a\u898b\uff1a\u30d5\u30a1\u30a4\u30a2\u3068\u30e1\u30ed<\/h4>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\">\n<p>\u3000\u30a2\u30e1\u30ea\u30ab\u4eba\u306e\u30d5\u30a1\u30a4\u30a2\uff08A. Z. Fire\uff09\u306f\u3001\u7559\u5b66\u5148\u3067\u3042\u308b\u30a4\u30ae\u30ea\u30b9\u306e\u30b1\u30f3\u30d6\u30ea\u30c3\u30b8\u5927\u5b66\u306e\u5206\u5b50\u751f\u7269\u5b66\u7814\u7a76\u6240\u3067\u7dda\u866b\u306e\u7814\u7a76\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u305d\u3053\u3067\u3001\u7dda\u866b\u306bDNA\u3092\u6ce8\u5165\u3057\u3066\u907a\u4f1d\u5b50\u3092\u767a\u73fe\u3055\u305b\u308b\u300c<strong>\u5f62\u8cea\u8ee2\u63db<\/strong>\u300d\u3068\u3044\u3046\u6280\u8853\u3092\u78ba\u7acb\u3057\u307e\u3057\u305f\uff081986\u5e74\u8ad6\u6587\u767a\u8868\uff09\u3002\u30a2\u30e1\u30ea\u30ab\u306b\u5e30\u56fd\u5f8c\u30011986\u5e74\u304b\u3089\u30ab\u30fc\u30cd\u30ae\u30fc\u767a\u751f\u5b66\u7814\u7a76\u6240\u306e\u7814\u7a76\u54e1\u3068\u306a\u308a\u3001\u7dda\u866b\u306b\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u3092\u5c0e\u5165\u3057\u3001\u767a\u73fe\u3055\u305b\u308b\u76ee\u7684\u3067\u3001\u904b\u3073\u5c4b\uff08<strong>\u30d9\u30af\u30bf\u30fc<\/strong>\uff09\u3068\u3057\u3066\u5229\u7528\u3067\u304d\u308b<strong>\u30d7\u30e9\u30b9\u30df\u30c9<\/strong>\uff08\u74b0\u72b6DNA\uff09\u3092\u4f5c\u6210\u3057\u307e\u3057\u305f\u3002<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" width=\"330\" height=\"235\" src=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2026\/02\/b7563be73cff3fb18296b100241ea672.png\" alt=\"\" class=\"wp-image-1292\" style=\"width:404px;height:auto\" srcset=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2026\/02\/b7563be73cff3fb18296b100241ea672.png 330w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2026\/02\/b7563be73cff3fb18296b100241ea672-300x214.png 300w\" sizes=\"(max-width: 330px) 100vw, 330px\" \/><\/figure>\n<\/div><\/div>\n<\/div>\n\n\n\n<p>\u6b21\u306b\u3001\u767a\u73fe\u3092\u6291\u3048\u305f\u3044\u6a19\u7684\u907a\u4f1d\u5b50\u306e\u30e1\u30c3\u30bb\u30f3\u30b8\u30e3\u30fcRNA\uff08mRNA\uff09\u3068\u76f8\u88dc\u7684\u306a\u6838\u9178\uff08<strong>\u30a2\u30f3\u30c1\u30bb\u30f3\u30b9\u6838\u9178<\/strong>\uff09\u306b\u95a2\u9023\u3057\u305f\u7814\u7a76\u3092\u884c\u3044\u3001\u30a2\u30e1\u30ea\u30ab\u4eba\u306e\u30e1\u30ed\uff08C. Mello\uff09\u3068\u5171\u306b\u30012\u672c\u9396RNA\u306b\u3088\u308b\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u306e\u5f37\u529b\u306a\u767a\u73fe\u6291\u5236\u306e\u73fe\u8c61\u3068\u305d\u306e\u6a5f\u69cb\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u73fe\u8c61\u306f<strong>RNA\u5e72\u6e09<\/strong>\u3068\u547c\u3070\u308c\u3001\u751f\u7269\u754c\u3067\u304b\u306a\u308a\u666e\u904d\u7684\u306a\u73fe\u8c61\u3067\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u696d\u7e3e\u306b\u3088\u308a\u3001\u30d5\u30a1\u30a4\u30a2\u3068\u30e1\u30ed\u306f2006\u5e74\u306b\u30ce\u30fc\u30d9\u30eb\u751f\u7406\u5b66\u30fb\u533b\u5b66\u8cde\u3092\u53d7\u8cde\u3057\u307e\u3057\u305f\uff08\u300cRNA\u5e72\u6e09\u3001\u307e\u305f\u306f\uff12\u672c\u9396RNA\u306b\u3088\u308b\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u6291\u5236\u3001\u306e\u767a\u898b\u300d\uff09\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\uff08\uff13\uff09GFP\u306e\u5229\u7528\uff1a\u30c1\u30e3\u30eb\u30d5\u30a3\u30fc<\/h4>\n\n\n\n<p>\u30a2\u30e1\u30ea\u30ab\u4eba\u306e\u30c1\u30e3\u30eb\u30d5\u30a3\u30fc\uff08M. Chalfie\uff09\u306f\u3001\u82f1\u56fd\u30b1\u30f3\u30d6\u30ea\u30c3\u30b8\u5927\u5b66\u5206\u5b50\u751f\u7269\u5b66\u7814\u7a76\u6240\u306e\u535a\u58eb\u7814\u7a76\u54e1\u3092\u7d4c\u30661982\u5e74\u306b\u30a2\u30e1\u30ea\u30ab\u306b\u623b\u308a\u3001\u30b3\u30ed\u30f3\u30d3\u30a2\u5927\u5b66\u3067\u7dda\u866b\u306e\u6a5f\u68b0\u7684\u523a\u6fc0\uff08\u63a5\u89e6\uff09\u306e\u5909\u7570\u4f53\u306e\u7814\u7a76\u3092\u7d9a\u3051\u3066\u3044\u307e\u3057\u305f\u3002\u5f7c\u306f1989\u5e74\u306bGFP\uff08Green Fluorescent Protein\uff09\u3068\u547c\u3070\u308c\u308b\u7dd1\u8272\u306e\u86cd\u5149\u3092\u767a\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5b58\u5728\u3092\u77e5\u308a\u3001\u3053\u308c\u3092\u7dda\u866b\u5185\u3067\u306e\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u53ef\u8996\u5316\u306b\u4f7f\u3044\u305f\u3044\u3068\u8003\u3048\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>GFP\u306f\u30a2\u30e1\u30ea\u30ab\u3067\u7814\u7a76\u3092\u3057\u3066\u3044\u305f\u65e5\u672c\u4eba\u306e\u4e0b\u6751\u4fee\u306b\u3088\u308a\u3001\u30aa\u30ef\u30f3\u30af\u30e9\u30b2\u304b\u3089\u5206\u96e2\u30fb\u540c\u5b9a\u3055\u308c\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3001\u30a6\u30c3\u30ba\u30db\u30fc\u30eb\u6d77\u6d0b\u7814\u7a76\u6240\u306e\u30d7\u30e9\u30c3\u30b7\u30e3\u30fc\u306b\u3088\u308a\u3001\u305d\u306emRNA\u306e\u914d\u5217\u3092DNA\u306b\u8ee2\u63db\u3057\u305fcDNA\uff08\u76f8\u88dc\u7684DNA\uff09\u304c\u4f5c\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u30c1\u30e3\u30eb\u30d5\u30a3\u30fc\u306f\u305d\u308c\u3092\u3082\u3089\u3044\u3001\u7dda\u866b\u306e\u6a5f\u68b0\u611f\u899a\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u958b\u59cb\u4fe1\u53f7\uff08\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\uff09\u3068GFP\u3092\u7d50\u5408\u3057\u305f\u30d7\u30e9\u30b9\u30df\u30c9\u3092\u4f5c\u6210\u3057\u3001\u7dda\u866b\u306b\u5c0e\u5165\u3057\u307e\u3057\u305f\u3002\u3059\u308b\u3068\u3001\u898b\u4e8b\u306b\u7dda\u866b\u306e\u6a5f\u68b0\u611f\u899a\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u307f\u304c\u7dd1\u8272\u86cd\u5149\u3092\u767a\u3057\u305f\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u30c1\u30e3\u30eb\u30d5\u30a3\u30fc\u306f\u3053\u306e\u696d\u7e3e\u306b\u3088\u308a\u3001\u4e0b\u6751\u4fee\u3001GFP\u306e\u6539\u5909\u3092\u884c\u3063\u305f\u30c1\u30a7\u30f3\uff08R. Y. Tsien\uff09\u3068\u5171\u306b2008\u5e74\u30ce\u30fc\u30d9\u30eb\u5316\u5b66\u8cde\u3092\u53d7\u8cde\u3057\u307e\u3057\u305f\uff08\u300c\u7dd1\u8272\u86cd\u5149\u30bf\u30f3\u30d1\u30af\u8cea\uff08GFP\uff09\u306e\u767a\u898b\u3068\u767a\u5c55\u300d\uff09\u3002\u3061\u306a\u307f\u306b\u3001\u30c1\u30e3\u30eb\u30d5\u30a3\u30fc\u306eGFP\u306b\u3064\u3044\u3066\u306e\u7814\u7a76\u671f\u9593\u306f\u308f\u305a\u304b2\u9031\u9593\u7a0b\u5ea6\u3060\u3063\u305f\u305d\u3046\u3067\u3059\u3002&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\uff08\uff14\uff09\u30de\u30a4\u30af\u30edRNA\uff1a\u30e9\u30d6\u30ab\u30f3\u3001\u30a2\u30e0\u30d6\u30ed<\/h4>\n\n\n\n<p>\u5171\u306b\u30a2\u30e1\u30ea\u30ab\u4eba\u3067\u3042\u308b\u30e9\u30d6\u30ab\u30f3\uff08G. Ruvkun\uff09\u3068\u30a2\u30e0\u30d6\u30ed\uff08V. Ambros\uff09\u306f\u3001\u7dda\u866b\u306b\u304a\u3044\u3066\u30de\u30a4\u30af\u30edRNA\uff08microRNA\uff09\u306e\u5b9f\u4f53\u3068\u305d\u306e\u6a5f\u80fd\u306e\u7814\u7a76\u3092\u7cbe\u529b\u7684\u306b\u884c\u3044\u307e\u3057\u305f\u3002\u30de\u30a4\u30af\u30edRNA\u306f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u306a\u3044\u5c0f\u3055\u3044RNA\u3067\u3001\u7dda\u866b\u306b\u304a\u3044\u3066\u306f140\u4ee5\u4e0a\u306e\u907a\u4f1d\u5b50\u304b\u3089\u767a\u73fe\u3055\u308c\u3001\u767a\u751f\u30fb\u884c\u52d5\u30fb\u4ee3\u8b1d\u30fb\u74b0\u5883\u5909\u5316\u306b\u5bfe\u3059\u308b\u884c\u52d5\u306a\u3069\u3092\u8abf\u7bc0\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u30de\u30a4\u30af\u30edRNA\u306e\u767a\u898b\u306b\u3064\u3044\u3066\u3001\u3053\u306e2\u4eba\u306f2024\u5e74\u306e\u30ce\u30fc\u30d9\u30eb\u751f\u7406\u5b66\u30fb\u533b\u5b66\u8cde\u3092\u53d7\u8cde\u3057\u307e\u3057\u305f\u3002&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<\/p>\n\n\n\n<p><strong>\u76e3\u4fee\u8005<\/strong><br>\u5927\u5cf6\u3000\u9756\u7f8e 1940\u5e74\u795e\u5948\u5ddd\u770c\u751f\u307e\u308c\u3002\u6771\u4eac\u5927\u5b66\u5927\u5b66\u9662\u535a\u58eb\u8ab2\u7a0b\u4fee\u4e86\u3002\u7c73\u56fd\u30ab\u30fc\u30cd\u30ae\u30fc\u767a\u751f\u5b66\u7814\u7a76\u6240\u535a\u58eb\u7814\u7a76\u54e1\u3001\u4e5d\u5dde\u5927\u5b66\u7406\u5b66\u90e8\u6559\u6388\u306a\u3069\u3092\u7d4c\u3066\u3001\u73fe\u5728\u306f\u4e5d\u5dde\u5927\u5b66\u540d\u8a89\u6559\u6388\u3002\u4e3b\u306a\u8457\u66f8\u306b\u300e\u7dda\u866b\u306e\u7814\u7a76\u3068\u30ce\u30fc\u30d9\u30eb\u8cde\u3078\u306e\u9053: 1\u30df\u30ea\u306e\u866b\u306e\u7814\u7a76\u304c\u306a\u305c3\u5ea6\u30ce\u30fc\u30d9\u30eb\u8cde\u3092\u53d7\u8cde\u3057\u305f\u304b\u300f\u300e\u52d5\u7269\u306f\u3044\u3064\u304b\u3089\u7720\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u306e\u304b? \u2015\u7dda\u866b\u3001\u30cf\u30a8\u304b\u3089\u30d2\u30c8\u306b\u81f3\u308b\u7761\u7720\u306e\u9032\u5316\u300f\u300e400\u5e74\u751f\u304d\u308b\u30b5\u30e1\u30014\u4e07\u5e74\u751f\u304d\u308b\u690d\u7269: \u751f\u7269\u306e\u5bff\u547d\u306f\u3069\u306e\u3088\u3046\u306b\u6c7a\u307e\u308b\u306e\u304b\u300f\u306a\u3069\u304c\u3042\u308b\u3002<\/p>\n\n\n\n<p class=\"has-text-align-right has-small-font-size\">\u00a92026 \u866b\u306e\u96c6\u3044\uff08\u7dda\u866b\u7814\u7a76\u8005\u30b3\u30df\u30e5\u30cb\u30c6\u30a3\uff09\u300c5.\u3000\u7dda\u866b\u306e\u7814\u7a76\u3068\u30ce\u30fc\u30d9\u30eb\u8cde\u300d<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">CC BY<\/a><\/p>\n\n\n\n<p class=\"has-text-align-right\"><a href=\"#toc_container\" data-type=\"internal\" data-id=\"#toc_container\">\u76ee\u6b21\u30da\u30fc\u30b8\u3078\u2191<\/a><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div><\/section>\n\n\n\n<section id=\"section-6\" class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h3 class=\"wp-block-heading\">6.\u3000\u533b\u7642\u30fb\u7523\u696d\u754c\u3078\u306e\u5fdc\u7528<\/h3>\n\n\n\n<h4 class=\"wp-block-heading\">\uff08\uff11\uff09GFP\u3092\u751f\u7269\u5229\u7528\u3059\u308b\u7a81\u7834\u53e3\u3068\u3057\u3066\u306e<em>C. elegans<\/em><\/h4>\n\n\n\n<p>GFP\uff08Green Fluorescent Protein\uff09\u306f\u30af\u30e9\u30b2\u7531\u6765\u306e\u86cd\u5149\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3001\u591a\u304f\u306e\u4eba\u306b\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3082\u3068\u3082\u3068\u306f\u4e0b\u6751\u4fee\u535a\u58eb\u304c\u30af\u30e9\u30b2\u304b\u3089\u7cbe\u88fd\u3057\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6027\u8cea\u3092\u8abf\u3079\u3001\u305d\u308c\u3092\u30d7\u30e9\u30c3\u30b7\u30e3\u30fc\uff08D. C. Prasher\uff09\u535a\u58eb\u304c\u30af\u30ed\u30fc\u30cb\u30f3\u30b0\u3057\u305f\u3082\u306e\u3067\u3059\u304c\u3001\u30c1\u30e3\u30eb\u30d5\u30a3\u30fc\uff08M. Chalfie\uff09\u535a\u58eb\u304c\u7dda\u866b\u306e\u30c8\u30e9\u30f3\u30b9\u30b8\u30a7\u30cb\u30c3\u30af\u4f53\u3067\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u751f\u4f53\u67d3\u8272\u3092\u884c\u3063\u305f\u3053\u3068\u3067\u3001\u751f\u547d\u79d1\u5b66\u7814\u7a76\u306b\u5fdc\u7528\u3067\u304d\u308b\u3053\u3068\u304c\u521d\u3081\u3066\u793a\u3055\u308c\u305f\u306e\u3067\u3059\u3002\u305d\u306e\u5f8c\u3001\u591a\u304f\u306e\u7814\u7a76\u8005\u304c\u3044\u308d\u3044\u308d\u306a\u751f\u7269\u7a2e\u306b\u304a\u3044\u3066\u540c\u69d8\u306e\u5b9f\u9a13\u3092\u884c\u3063\u305f\u7d50\u679c\u3001\u300c\u5149\u308b\u30af\u30e9\u30b2\u300d\u306f\u7814\u7a76\u8005\u306e\u307f\u306a\u3089\u305a\u3001\u8ab0\u3082\u304c\u77e5\u308b\u5b58\u5728\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u30c1\u30a7\u30f3\uff08R. Y. Tsien\uff09\u535a\u58eb\u30b0\u30eb\u30fc\u30d7\u306e\u8ad6\u6587\u306b\u306f\u3001GFP\u306b\u30a2\u30df\u30ce\u9178\u7f6e\u63db\u3092\u5c0e\u5165\u3059\u308b\u3053\u3068\u3067\u5149\u7279\u6027\u304c\u5909\u5316\u3059\u308b\u3053\u3068\u304c\u8a18\u8f09\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u5f8c\u3001GFP\u306e\u86cd\u5149\u7279\u6027\u5909\u7570\u4f53\u3092\u59cb\u3081\u3068\u3057\u3066\u3001\u4ed6\u306e\u86cd\u5149\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6d3b\u7528\u3082\u76db\u3093\u306b\u306a\u308a\u307e\u3057\u305f\u3002GFP\u3092\u4ed6\u306e\u86cd\u5149\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u878d\u5408\u3057\u305f\u308a\u3001GFP\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u30bb\u30f3\u30b5\u30fc\u6a5f\u80fd\u3092\u6301\u3064\u30c9\u30e1\u30a4\u30f3\u3092\u8ffd\u52a0\u3059\u308b\u306a\u3069\u306e\u65b9\u6cd5\u3067\u3001\u591a\u304f\u306e\u751f\u4f53\u5185\u30bb\u30f3\u30b5\u30fc\u304c\u5275\u308a\u51fa\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u3089\u306f\u7dda\u866b\u306b\u9650\u3089\u305a\u3001\u4ed6\u306e\u30e2\u30c7\u30eb\u751f\u7269\u3084\u57f9\u990a\u7d30\u80de\u3067\u3082\u5229\u7528\u3067\u304d\u308b\u305f\u3081\u3001\u907a\u4f1d\u5b50\u5de5\u5b66\u7684\u306b\u4f5c\u6210\u3057\u305f\u9ad8\u6a5f\u80fd\u306a\u86cd\u5149\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30d0\u30a4\u30aa\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u4f01\u696d\u304c\u8ca9\u58f2\u3057\u305f\u308a\u3001\u7814\u7a76\u8005\u304cAddgene\uff08https:\/\/www.addgene.org\uff09\u306a\u3069\u306e\u4f01\u696d\u306b\u59d4\u8a17\u3057\u3066\u63d0\u4f9b\u3057\u305f\u308a\u3001\u3068\u3044\u3063\u305f\u3057\u304f\u307f\u306b\u6210\u9577\u3057\u3066\u3044\u307e\u3059\u3002\u7dda\u866b\u3067\u7a81\u7834\u53e3\u3092\u958b\u3044\u305f\u6280\u8853\u304c\u3001\u305d\u306e\u5f8c\u3001\u5e83\u7bc4\u306a\u751f\u7269\u7a2e\u306e\u7814\u7a76\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3057\u305f\u4e00\u4f8b\u3068\u3044\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\uff08\uff12\uff09\u30d2\u30c8\u306e\u75be\u60a3\u306e\u7406\u89e3\u306b\u5fdc\u7528\u3067\u304d\u308b\u7a81\u7834\u53e3\u3068\u3057\u3066\u306e<em>C. elegans<\/em><\/h4>\n\n\n\n<p><em>C. elegans<\/em>\u306f\u3001\u500b\u4f53\u306e\u5f62\u614b\u5b66\u7684\u306a\u8a18\u8f09\u304c\u3042\u308b\u3001\u7d30\u80de\u7cfb\u8b5c\u3084\u7d30\u80de\u306e\u6a5f\u80fd\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u308b\u3001\u751f\u6d3b\u74b0\u304c\u77ed\u3044\u3001\u98fc\u80b2\u304c\u5bb9\u6613\u3001\u30b2\u30ce\u30e0\u89e3\u6790\u304c\u9032\u3093\u3067\u3044\u308b\u306a\u3069\u3001\u30e2\u30c7\u30eb\u751f\u7269\u3068\u3057\u3066\u306e\u30e1\u30ea\u30c3\u30c8\u304c\u305f\u304f\u3055\u3093\u3042\u308a\u307e\u3059\u3002\u521d\u671f\u306e<em>C. elegans<\/em>\u7814\u7a76\u3067\u306f\u3001\u3053\u308c\u3089\u306e\u7279\u6027\u306f\u3082\u3063\u3071\u3089\u751f\u7269\u5b66\u7684\u306a\u77e5\u8b58\u306e\u84c4\u7a4d\u306b\u5f79\u7acb\u3066\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u30e2\u30c7\u30eb\u751f\u7269\u3068\u3057\u3066\u78ba\u7acb\u3057\u3001\u7814\u7a76\u8005\u6570\u304c\u591a\u304f\u306a\u3063\u3066\u304b\u3089\u306f\u3001<em>C. elegans<\/em>\u3092\u300c\u30d2\u30c8\u304c\u3088\u308a\u826f\u304f\u751f\u304d\u3066\u3044\u304f\u305f\u3081\u306e\u30c4\u30fc\u30eb\u300d\u3068\u3057\u3066\u4f7f\u3046\u7814\u7a76\u8005\u304c\u5897\u3048\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u305f\u3068\u3048\u3070\u3001\u4eba\u985e\u306b\u3068\u3063\u3066\u91cd\u8981\u304b\u3064\u60a3\u8005\u6570\u304c\u591a\u3044\u75be\u60a3\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u308b\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306f\u3001\u8133\u306e\u795e\u7d4c\u7d30\u80de\u306e\u5909\u6027\u306b\u3088\u3063\u3066\u767a\u75c7\u3059\u308b\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u75c5\u6c17\u306f\u30d2\u30c8\u306e\u8001\u5316\u306b\u4f34\u3063\u3066\u767a\u75c7\u3057\u307e\u3059\u304c\u3001<em>C. elegans<\/em>\u306f\u5bff\u547d\u304c\u77ed\u3044\u304c\u3086\u3048\u306b\u8001\u5316\u306b\u95a2\u4fc2\u3059\u308b\u75be\u60a3\u306e\u89e3\u6790\u304c\u3057\u3084\u3059\u3044\u305f\u3081\u3001\u76db\u3093\u306b\u5229\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7dda\u866b\u306f\u5b9f\u9a13\u30e2\u30c7\u30eb\u3068\u3057\u3066\u306f\u6709\u7528\u3067\u3059\u304c\u3001\u305d\u308c\u3060\u3051\u3067\u533b\u7642\u3084\u7523\u696d\u306b\u4f7f\u3046\u306b\u306f\u56f0\u96e3\u304c\u4f34\u3044\u307e\u3059\u3002\u5c11\u306a\u304f\u3068\u3082\u5916\u898b\u4e0a\u306f\u69cb\u9020\u3084\u81d3\u5668\u69cb\u6210\u304c\u30d2\u30c8\u3068\u4f3c\u3066\u304a\u3089\u305a\u3001\u30de\u30a6\u30b9\u306a\u3069\u306e\u54fa\u4e73\u985e\u5b9f\u9a13\u30e2\u30c7\u30eb\u3068\u540c\u3058\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p>\u4e0a\u8ff0\u306e\u3088\u3046\u306b\u3001\u7dda\u866b\u3067\u306f\u751f\u7269\u5b66\u7684\u306a\u77e5\u898b\u53d6\u5f97\u3084\u30b2\u30ce\u30e0\u89e3\u6790\u304c\u5148\u884c\u3057\u3001\u30d2\u30c8\u3088\u308a\u3082\u6570\u5e74\u65e9\u304f\u30011998\u5e74\u306b\u5168\u30b2\u30ce\u30e0\u89e3\u8aad\u304c\u5b8c\u4e86\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u969b\u3001\u69cb\u9020\u3084\u6a5f\u80fd\u306e\u9762\u3067\u30d2\u30c8\u3068\u985e\u4f3c\u6027\u304c\u9ad8\u3044\u3068\u601d\u308f\u308c\u308b\u907a\u4f1d\u5b50\u304c\u305f\u304f\u3055\u3093\u767a\u898b\u3055\u308c\u3001\u5206\u5b50\u7d30\u80de\u30ec\u30d9\u30eb\u3067\u306f\u7dda\u866b\u3068\u30d2\u30c8\u304c\u3088\u304f\u4f3c\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u305d\u306e\u4e2d\u3067\u3082\u3001\u30de\u30a4\u30af\u30edRNA\u306f\u3001\u7dda\u866b\u306e\u767a\u751f\u751f\u7269\u5b66\u89e3\u6790\u3067\u521d\u3081\u3066\u767a\u898b\u3055\u308c\u305f\u4ee3\u8868\u4f8b\u3067\u3059\u3002\u30de\u30a4\u30af\u30edRNA\u306f\u305d\u306e\u5f8c\u3001\u30d2\u30c8\u30b2\u30ce\u30e0\u4e0a\u306b\u3082\u591a\u6570\u5b58\u5728\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u3001\u7dda\u866b\u3068\u985e\u4f3c\u306e\u4f5c\u7528\u3092\u6301\u3063\u3066\u3044\u308b\u3053\u3068\u3001\u305d\u306e\u767a\u73fe\u5909\u5316\u304c\u30d2\u30c8\u306e\u75be\u60a3\u3068\u91cd\u8981\u306a\u95a2\u4fc2\u3092\u3082\u3064\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u30022024\u5e74\u306b\u306f\u305d\u306e\u696d\u7e3e\u3067\u30a2\u30e0\u30d6\u30ed\uff08V. Ambros\uff09\u3068\u30e9\u30d6\u30ab\u30f3\uff08G. Ruvkun\uff09\u306b\u30ce\u30fc\u30d9\u30eb\u751f\u7406\u5b66\u533b\u5b66\u8cde\u304c\u6388\u4e0e\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30d2\u30c8\u306e\u30de\u30a4\u30af\u30edRNA\u304c\u75be\u60a3\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u95a2\u308f\u3063\u3066\u3044\u308b\u3068\u3059\u308b\u7814\u7a76\u8ad6\u6587\u304c\u591a\u6570\u767a\u8868\u3055\u308c\u3066\u3044\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u73fe\u5728\u3001\u30de\u30a4\u30af\u30edRNA\u3092\u6e2c\u5b9a\u3059\u308b\u3053\u3068\u3067\u764c\u306e\u8a3a\u65ad\u304c\u53ef\u80fd\u3001\u3068\u3044\u3046\u3068\u3053\u308d\u307e\u3067\u9032\u3093\u3067\u304a\u308a\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u30d3\u30b8\u30cd\u30b9\u3082\u59cb\u307e\u308a\u305d\u3046\u3067\u3059\u3002\u5148\u99c6\u7684\u306a\u4ed5\u7d44\u307f\u306e\u89e3\u660e\u304c\u533b\u7642\u30fb\u7523\u696d\u306b\u5fdc\u7528\u3055\u308c\u308b\u3053\u3068\u306f\u3088\u304f\u3042\u308b\u3053\u3068\u3067\u3001\u7dda\u866b\u3082\u4f8b\u5916\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p><strong>\u53c2\u8003\u8cc7\u6599<\/strong><br>1) Shimomura O\u8457 \u300cStructure of the chromophore of Aequorea Green Fluorescent Protein\u300d\u30011979\u5e74 FEBS Letters, 104:220-222<\/p>\n\n\n\n<p>2) Prasher DC\u3089\u8457\u300cPrimary structure of the Aequorea victoria green-fluorescent protein\u300d\u30011992\u5e74 Gene, 15;111(2):229-33. doi: 10.1016\/0378-1119(92)90691-h<\/p>\n\n\n\n<p>3) Chalfie M\u3089\u8457 \u300cGreen fluorescent protein as a marker for gene expression\u300d\u30011994\u5e74 Science, 11;263(5148):802-5. doi: 10.1126\/science.8303295<\/p>\n\n\n\n<p>4) Heim R\u3089\u8457 \u300cWavelength mutations and posttranslational autooxidation of green fluorescent protein\u300d\u30011994\u5e74 Proc. Natl. Acad. Sci. USA, 91, 12501-12504.<\/p>\n\n\n\n<p>5) Lee RC\u3089\u8457 \u300cThe <em>C. elegans<\/em> heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14\u300d\u30011993\u5e74\u3000Cell, 3;75(5):843-54, doi: 10.1016\/0092-8674(93)90529-y.<\/p>\n\n\n\n<p>6) Wightman B\u3089\u8457 \u300cPosttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in <em>C. elegans<\/em>\u300d\u30011993\u5e74 Cell, 3;75(5):855-62, doi: 10.1016\/0092-8674(93)90530-4.<\/p>\n\n\n\n<p>7) Matsuzaki J\u3089\u8457 \u300cPrediction of tissue-of-origin of early stage cancers using serum miRNomes\u300d\u30012023\u5e74\u3000JNCI Cancer Spectr, 3;7(1):pkac080, doi: 10.1093\/jncics\/pkac080.<\/p>\n\n\n\n<p><strong>\u76e3\u4fee\u8005<\/strong><br>\u4e09\u8c37\u3000\u660c\u5e73 1958\u5e74\u9ce5\u53d6\u770c\u751f\u307e\u308c\u3002\u6771\u4eac\u5927\u5b66\u533b\u5b66\u90e8\u533b\u5b66\u79d1\u5352\u696d\u3001\u533b\u5e2b\u30022024\u5e74\u3001\u6771\u4eac\u5973\u5b50\u533b\u79d1\u5927\u5b66\u540d\u8a89\u6559\u6388\u3001\u65e5\u672c\u6b6f\u79d1\u5927\u5b66\u751f\u547d\u6b6f\u5b66\u90e8\u5ba2\u54e1\u6559\u6388\u30012025\u5e744\u6708\u304b\u3089\u306f\u6771\u4eac\u5973\u5b50\u533b\u79d1\u5927\u5b66\u5b66\u9577\u3002\u00a0\u00a0<\/p>\n\n\n\n<p class=\"has-text-align-right has-small-font-size\">\u00a92026 \u866b\u306e\u96c6\u3044\uff08\u7dda\u866b\u7814\u7a76\u8005\u30b3\u30df\u30e5\u30cb\u30c6\u30a3\uff09\u300c6.\u3000\u533b\u7642\u30fb\u7523\u696d\u754c\u3078\u306e\u5fdc\u7528\u300d<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">CC BY<\/a><\/p>\n\n\n\n<p class=\"has-text-align-right\"><a href=\"#toc_container\" data-type=\"internal\" data-id=\"#toc_container\">\u76ee\u6b21\u30da\u30fc\u30b8\u3078\u2191<\/a><\/p>\n<\/div><\/section>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u76ee\u6b21 Illustrated by Hiroko Uchida&nbsp; &nbsp; \u300c\u7dda\u866b\u300d\u3068 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":666,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-686","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-json\/wp\/v2\/pages\/686","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-json\/wp\/v2\/comments?post=686"}],"version-history":[{"count":31,"href":"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-json\/wp\/v2\/pages\/686\/revisions"}],"predecessor-version":[{"id":1341,"href":"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-json\/wp\/v2\/pages\/686\/revisions\/1341"}],"up":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-json\/wp\/v2\/pages\/666"}],"wp:attachment":[{"href":"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-json\/wp\/v2\/media?parent=686"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}