{"id":677,"date":"2025-02-03T11:27:07","date_gmt":"2025-02-03T02:27:07","guid":{"rendered":"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/?page_id=677"},"modified":"2026-02-12T17:34:53","modified_gmt":"2026-02-12T08:34:53","slug":"about-5","status":"publish","type":"page","link":"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/about\/about-5\/","title":{"rendered":"\u7dda\u866b\u304b\u3089\u751f\u307e\u308c\u305f\u65b0\u6280\u8853"},"content":{"rendered":"\n<div id=\"toc_container\" class=\"wp-block-group pada_30\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h2 class=\"wp-block-heading\">\u76ee\u6b21<\/h2>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<ul class=\"wp-block-list\">\n<li class=\"has-medium-font-size\"><strong><a href=\"#section-1\" data-type=\"internal\" data-id=\"#section-1\">\u5168\u30b2\u30ce\u30e0\u5869\u57fa\u914d\u5217\u6c7a\u5b9a<\/a><\/strong><\/li>\n\n\n\n<li class=\"has-medium-font-size\"><strong><a href=\"#section-2\">GFP\u3068G-CaMP<\/a><\/strong><\/li>\n\n\n\n<li class=\"has-medium-font-size\"><strong><a href=\"#section-3\">RNA\u5e72\u6e09\u3068\u30de\u30a4\u30af\u30edRNA<\/a><\/strong><\/li>\n\n\n\n<li class=\"has-medium-font-size\"><strong><a href=\"#section-4\">\u7dda\u866b\u306b\u304a\u3051\u308b\u5168\u8133\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0<\/a><\/strong><\/li>\n\n\n\n<li class=\"has-medium-font-size\"><strong><a href=\"#section-5\">\u7dda\u866b\u5b9f\u9a13\u30fb\u89e3\u6790\u306e\u305f\u3081\u306e\u30de\u30a4\u30af\u30ed\u30c1\u30c3\u30d7<\/a><\/strong><\/li>\n<\/ul>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"592\" src=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2026\/02\/1007a116d3cdd3d73d2fee1360c6a1e5-1024x592.jpg\" alt=\"\" class=\"wp-image-1318\" srcset=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2026\/02\/1007a116d3cdd3d73d2fee1360c6a1e5-1024x592.jpg 1024w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2026\/02\/1007a116d3cdd3d73d2fee1360c6a1e5-300x173.jpg 300w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2026\/02\/1007a116d3cdd3d73d2fee1360c6a1e5-768x444.jpg 768w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2026\/02\/1007a116d3cdd3d73d2fee1360c6a1e5-1536x888.jpg 1536w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2026\/02\/1007a116d3cdd3d73d2fee1360c6a1e5-2048x1183.jpg 2048w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2026\/02\/1007a116d3cdd3d73d2fee1360c6a1e5-670x387.jpg 670w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"has-text-align-right\">Illustrated by Hiroko Uchida<\/p>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group\" style=\"font-size:1.2em\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<p>\u3000\u7dda\u866b\u3092\u5bfe\u8c61\u3068\u3057\u305f\u751f\u547d\u79d1\u5b66\u7814\u7a76\u306e\u9032\u5c55\u306f\u3001\u7814\u7a76\u8005\u30fb\u6280\u8853\u8005\u306e\u5c02\u9580\u77e5\u8b58\u3084\u30a2\u30a4\u30c7\u30a3\u30a2\u304b\u3089\u751f\u307e\u308c\u305f\u9769\u65b0\u6280\u8853\u306b\u3088\u3063\u3066\u652f\u3048\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u3053\u3046\u3057\u305f\u6280\u8853\u306e\u4e2d\u306b\u306f\u3001\u7dda\u866b\u4ee5\u5916\u306e\u751f\u7269\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3055\u307e\u3056\u307e\u306a\u5206\u91ce\u306e\u7814\u7a76\u306b\u6ce2\u53ca\u3057\u3001\u306a\u304f\u3066\u306f\u306a\u3089\u306a\u3044\u6280\u8853\u3068\u3057\u3066\u5b9a\u7740\u3057\u305f\u3082\u306e\u304c\u6570\u591a\u304f\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u305d\u306e\u4e2d\u304b\u3089\u30011982\u5e74\u306b\u591a\u7d30\u80de\u751f\u7269\u3067\u521d\u3081\u3066\u7dda\u866b\u3067\u5b9f\u73fe\u3057\u305f\u5168\u30b2\u30ce\u30e0\u5869\u57fa\u914d\u5217\u6c7a\u5b9a\uff085-1\uff09\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3092\u53ef\u80fd\u3068\u3059\u308b\u91cd\u8981\u306a\u30c4\u30fc\u30eb\u3067\u3042\u308a\u30012006\u5e74\u30682024\u5e74\u306b\u30ce\u30fc\u30d9\u30eb\u751f\u7406\u5b66\u30fb\u533b\u5b66\u8cde\u3092\u53d7\u8cde\u3057\u305fRNA\u5e72\u6e09\uff08RNAi\uff09\u3068\u30de\u30a4\u30af\u30edRNA\uff08miRNA\uff09\uff085-2\uff09\u3001\u751f\u7269\u5b66\u7684\u30d7\u30ed\u30bb\u30b9\u3092\u53ef\u8996\u5316\u3059\u308b\u5f37\u529b\u306a\u30c4\u30fc\u30eb\u3067\u3042\u308bG-CaMP\uff08\u30b8\u30fc\u30ad\u30e3\u30f3\u30d7\uff09\uff085-3\uff09\u3001\u7dda\u866b\u306e\u8133\u306e\u3059\u3079\u3066\u306e\u795e\u7d4c\u7d30\u80de\u306e\u6d3b\u52d5\u306e\u5909\u5316\u3092\u9855\u5fae\u93e1\u3067\u6e2c\u5b9a\u53ef\u80fd\u306b\u3057\u305f\u5168\u8133\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\uff085-4\uff09\u3001\u7dda\u866b\u5b9f\u9a13\u30fb\u89e3\u6790\u306e\u305f\u3081\u306e\u30de\u30a4\u30af\u30ed\u30c1\u30c3\u30d7\uff085-5\uff09\u306b\u3064\u3044\u3066\u3001\u5468\u8fba\u60c5\u5831\u3092\u3075\u307e\u3048\u3066\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u76e3\u4fee\u8005<\/strong><br>\u9234\u6728 \u82b3\u4ee3\uff08\u56fd\u7acb\u7814\u7a76\u958b\u767a\u6cd5\u4eba\u91cf\u5b50\u79d1\u5b66\u6280\u8853\u7814\u7a76\u958b\u767a\u6a5f\u69cb \u9ad8\u5d0e\u91cf\u5b50\u6280\u8853\u57fa\u76e4\u7814\u7a76\u6240\uff09<\/p>\n\n\n\n<p><strong>\u7814\u7a76\u5ba4HP<\/strong><br><a href=\"https:\/\/www.qst.go.jp\/site\/qabiotech\/\">https:\/\/www.qst.go.jp\/site\/qabiotech\/<\/a><\/p>\n\n\n\n<p class=\"has-text-align-right has-small-font-size\">\u00a92026 \u866b\u306e\u96c6\u3044\uff08\u7dda\u866b\u7814\u7a76\u8005\u30b3\u30df\u30e5\u30cb\u30c6\u30a3\uff09\u300c\u5e8f\u8ad6\u300d<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">CC BY<\/a><\/p>\n<\/div><\/div>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<section id=\"section-1\" class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h3 class=\"wp-block-heading\">1.\u3000\u5168\u30b2\u30ce\u30e0\u5869\u57fa\u914d\u5217\u6c7a\u5b9a<\/h3>\n\n\n\n<h4 class=\"wp-block-heading has-text-align-left\">\u5168\u30b2\u30ce\u30e0\u5869\u57fa\u914d\u5217\u306e\u6c7a\u5b9a<\/h4>\n\n\n\n<p>\u3000\u30b3\u30fc\u30eb\u30bd\u30f3(Coulson)\u3089\u306f\u3001\u7dda\u866b\u304b\u3089\u9ad8\u7d14\u5ea6\u306a\u30b2\u30ce\u30e0DNA\u3092\u62bd\u51fa\u3057\u3001\u7d30\u304b\u304f\u30e9\u30f3\u30c0\u30e0\u306b\u5207\u65ad\u3057\u3066\u4e00\u5b9a\u306e\u7bc4\u56f2\u306e\u9577\u3055\u3092\u3082\u3064DNA\u65ad\u7247\u3092\u4f5c\u6210\u3057\u3001\u30b3\u30b9\u30df\u30c9\u30d9\u30af\u30bf\u30fc<sup>\u203b\uff11<\/sup>\u306b\u633f\u5165\u3057\u3001\u30b2\u30ce\u30e0DNA\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc<sup>\u203b\uff12<\/sup>\u3092\u5b8c\u6210\u3055\u305b\u307e\u3057\u305f\u3002\u6b21\u306b\u3001\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc\u4e2d\u306e\u5404\u30af\u30ed\u30fc\u30f3\u306e\u7279\u5fb4\u7684\u30d1\u30bf\u30fc\u30f3\uff08\u30d5\u30a3\u30f3\u30ac\u30fc\u30d7\u30ea\u30f3\u30c8\uff09\u3092\u6bd4\u8f03\u3057\u3066\u3001\u91cd\u8907\u3059\u308b\u9818\u57df\u3092\u691c\u51fa\u3059\u308b\u3053\u3068\u3067\u30af\u30ed\u30fc\u30f3\u3069\u3046\u3057\u306e\u4f4d\u7f6e\u95a2\u4fc2\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u3053\u3046\u3057\u3066\u4f5c\u6210\u3055\u308c\u305f\u3001\u3042\u308b\u7a0b\u5ea6\u306e\u9577\u3055\u306e\u9818\u57df\u3092\u30ab\u30d0\u30fc\u3059\u308b\u30af\u30ed\u30fc\u30f3\u306e\u30b0\u30eb\u30fc\u30d7\u3092\u3001\u300c\u30b3\u30f3\u30c6\u30a3\u30b0\u300d\u3068\u3044\u3044\u307e\u3059\u3002\u8868\u73fe\u578b\u89e3\u6790\u3067\u540c\u5b9a\u3055\u308c\u305f\u65e2\u5b58\u306e\u5909\u7570\u4f53\u907a\u4f1d\u5b50\u306e\u907a\u4f1d\u5730\u56f3\u3092\u53c2\u7167\u3057\u306a\u304c\u3089\u3001\u5f97\u3089\u308c\u305f\u30b3\u30f3\u30c6\u30a3\u30b0\u3092\u67d3\u8272\u4f53\u4e0a\u306b\u5272\u308a\u5f53\u3066\u3066\u3044\u304f\u3053\u3068\u306b\u3088\u308a\u3001\u30b2\u30ce\u30e0\u7269\u7406\u5730\u56f3\u304c\u4f5c\u6210\u3055\u308c\u307e\u3057\u305f\u3002<br>\u3000\u5168\u30b2\u30ce\u30e0\u914d\u5217\u306f\u3001\u82f1\u56fd\u30b5\u30f3\u30ac\u30fc\u30bb\u30f3\u30bf\u30fc\u3068\u7c73\u56fd\u30ef\u30b7\u30f3\u30c8\u30f3\u5927\u5b66\u306b\u3066\u3001\u305d\u308c\u305e\u308c\u306e\u30b3\u30b9\u30df\u30c9\u3092\u3055\u3089\u306b\u7d30\u304b\u3044\u65ad\u7247\u306b\u30b5\u30d6\u30af\u30ed\u30fc\u30cb\u30f3\u30b0\u3057\u3066\u304b\u3089\u5869\u57fa\u914d\u5217\u89e3\u6790\u3092\u884c\u3046\u300c\u968e\u5c64\u7684\u30b7\u30e7\u30c3\u30c8\u30ac\u30f3\u6cd5\u300d\u306b\u3088\u3063\u3066\u6c7a\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002\u30b3\u30b9\u30df\u30c9\u306e\u307f\u3067\u306f\u89e3\u8aad\u3067\u304d\u306a\u3044\u9818\u57df\u304c\u591a\u6570\u6b8b\u308b\u305f\u3081\u3001\u3088\u308a\u5927\u304d\u306aDNA\u65ad\u7247\u3092\u30af\u30ed\u30fc\u30cb\u30f3\u30b0\u3067\u304d\u308b\u300c\u4eba\u5de5\u9175\u6bcd\u67d3\u8272\u4f53\u300d\u3092\u4f7f\u3063\u3066\u88dc\u5b8c\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u30011998\u5e7412\u6708\u306b\u3001\u591a\u7d30\u80de\u751f\u7269\u3067\u306f\u521d\u3081\u3066\u3001\u5168\u30b2\u30ce\u30e0\u5869\u57fa\u914d\u5217\u304c\u6c7a\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u203b1. \u30b3\u30b9\u30df\u30c9\u30d9\u30af\u30bf\u30fc\uff1a\u30d9\u30af\u30bf\u30fc\u3068\u306f\u300c\uff08\u907a\u4f1d\u5b50\u306e\uff09\u904b\u3073\u5c4b\u300d\u3092\u610f\u5473\u3057\u3001\u633f\u5165\u3055\u308c\u305fDNA\u306e\u65ad\u7247\u3092\u904b\u3076\u5f79\u5272\u3092\u3082\u3064\u74b0\u72b6\u306eDNA\u3067\u3001\u30b3\u30b9\u30df\u30c9\u30d9\u30af\u30bf\u30fc\u306f\u30d7\u30e9\u30b9\u30df\u30c9\u30d9\u30af\u30bf\u30fc\u3088\u308a\u3082\u5927\u304d\u306a\u65ad\u7247\u3092\u904b\u3076\u3053\u3068\u304c\u3067\u304d\u308b<br>\u203b2. \u30b2\u30ce\u30e0DNA\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc\uff1a\u9069\u5f53\u306a\u5927\u304d\u3055\u306b\u5207\u65ad\u3057\u305f\u30b2\u30ce\u30e0DNA\u3092\u30d9\u30af\u30bf\u30fc\u306b\u7d44\u307f\u8fbc\u307f\u3001\u5927\u8178\u83cc\u3084\u9175\u6bcd\u7d30\u80de\u306e\u4e2d\u3067\u4fdd\u7ba1\u3057\u305f\u3082\u306e<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"796\" height=\"1024\" src=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2026\/02\/b8f85c590afa96119fa36b3d9cb33140-796x1024.jpg\" alt=\"\" class=\"wp-image-1333\" srcset=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2026\/02\/b8f85c590afa96119fa36b3d9cb33140-796x1024.jpg 796w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2026\/02\/b8f85c590afa96119fa36b3d9cb33140-233x300.jpg 233w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2026\/02\/b8f85c590afa96119fa36b3d9cb33140-768x988.jpg 768w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2026\/02\/b8f85c590afa96119fa36b3d9cb33140-1193x1536.jpg 1193w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2026\/02\/b8f85c590afa96119fa36b3d9cb33140-670x862.jpg 670w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2026\/02\/b8f85c590afa96119fa36b3d9cb33140.jpg 1359w\" sizes=\"(max-width: 796px) 100vw, 796px\" \/><\/figure>\n\n\n\n<p class=\"has-text-align-right has-small-font-size\">Illustrated by Hiroko Uchida\u00a0<\/p>\n\n\n\n<h4 class=\"wp-block-heading has-text-align-left\">ACEDB\uff08A <em>C. elegans<\/em> database\uff09\u306e\u958b\u767a<\/h4>\n\n\n\n<p>\u3000\u30ea\u30c1\u30e3\u30fc\u30c9\u30fb\u30c0\u30fc\u30d3\u30f3(Richard Durbin) \u3068 \u30b8\u30fc\u30f3\u30fb\u30c6\u30a3\u30a8\u30ea\u30fc\u30fb\u30df\u30fc\u30b0(Jean Thierry-Mieg)\u306f\u3001\u7dda\u866b\u30b2\u30ce\u30e0\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3067\u751f\u3058\u308b\u81a8\u5927\u306a\u30c7\u30fc\u30bf\u3092\u6574\u7406\u30fb\u5171\u6709\u3059\u308b\u7dda\u866b\u30b2\u30ce\u30e0\u89e3\u6790\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u30b7\u30b9\u30c6\u30e0ACEDB\uff08A <em>C. elegans<\/em> database\uff09\u3092\u958b\u767a\u3057\u307e\u3057\u305f\uff081989\u5e74\uff09\u3002ACEDB\u306e\u30c7\u30fc\u30bf\u306f\u30aa\u30d6\u30b8\u30a7\u30af\u30c8\u6307\u5411\u3067\u69cb\u9020\u5316\u3055\u308c\u3066\u304a\u308a\u3001\u907a\u4f1d\u5b50\u3001\u67d3\u8272\u4f53\u3001\u30de\u30fc\u30ab\u30fc\u3001\u8868\u73fe\u578b\u306a\u3069\u304c\u5404\u30aa\u30d6\u30b8\u30a7\u30af\u30c8\u3068\u3057\u3066\u7ba1\u7406\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u5404\u30aa\u30d6\u30b8\u30a7\u30af\u30c8\u9593\u306e\u95a2\u4fc2\u6027\u304c\u660e\u793a\u3055\u308c\u3001\u76f4\u611f\u7684\u306a\u30c7\u30fc\u30bf\u89e3\u6790\u304c\u53ef\u80fd\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>ACEDB\u306f\u3001\u7dda\u866b\u7814\u7a76\u3092\u52a0\u901f\u3055\u305b\u308b\u3060\u3051\u3067\u306a\u304f\u3001ACEDB\u306e\u30aa\u30d6\u30b8\u30a7\u30af\u30c8\u6307\u5411\u30c7\u30fc\u30bf\u30e2\u30c7\u30eb\u306f\u3001\u73fe\u4ee3\u306e\u30b2\u30ce\u30e0\u89e3\u6790\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306e\u8a2d\u8a08\u306b\u3082\u5927\u304d\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3057\u305f\u3002\u73fe\u5728\u3001ACEDB\u306f\u3088\u308a\u9032\u5316\u3057\u305f\u30aa\u30f3\u30e9\u30a4\u30f3\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9WormBase\uff08<a href=\"https:\/\/wormbase.org\/\">https:\/\/wormbase.org\/<\/a>\uff09\u306b\u7d71\u5408\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u53c2\u8003\u8cc7\u6599<\/strong><br>1\uff09\u98ef\u91ce \u96c4\u4e00\uff08\u7de8\uff09, \u77f3\u4e95 \u76f4\u660e\uff08\u7de8\uff09 \u7dda\u866b \u7a76\u6975\u306e\u30e2\u30c7\u30eb\u751f\u7269 2002\u5e74 \u30b7\u30e5\u30d7\u30ea\u30f3\u30ac\u30fc\u30fb\u30b8\u30e3\u30d1\u30f3<br>2)   Eeckman FH, Durbin R (1995) ACeDB and macace&nbsp;<em>Methods Cell Biol<\/em>.&nbsp;<strong>48<\/strong>:&nbsp;583\u2013605.&nbsp;doi:10.1016\/s0091-679x(08)61405-3<br>3\uff09Coulson A, Sulston J, Brenner S, KarnToward J (1986) Toward a physical map of the genome of the nematode <em>Caenorhabditis elegans<\/em>. <em>Proc Natl Acad Sci U S A<\/em> Oct;83(20):7821-5. doi: 10.1073\/pnas.83.20.7821.<\/p>\n\n\n\n<p><strong>\u76e3\u4fee\u8005<\/strong><br>\u4f0a\u85e4\u3000 \u5c07\u5f18<br>\u7acb\u547d\u9928\u5927\u5b66 \u751f\u547d\u79d1\u5b66\u90e8 \u751f\u547d\u60c5\u5831\u5b66\u79d1<\/p>\n\n\n\n<p><strong>\u7814\u7a76\u5ba4HP<\/strong><br><a href=\"https:\/\/www.ritsumei.ac.jp\/lifescience\/bioinfo\/ito\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.ritsumei.ac.jp\/lifescience\/bioinfo\/ito\/<\/a><\/p>\n\n\n\n<p class=\"has-text-align-right has-small-font-size\">\u00a92026 \u866b\u306e\u96c6\u3044\uff08\u7dda\u866b\u7814\u7a76\u8005\u30b3\u30df\u30e5\u30cb\u30c6\u30a3\uff09\u300c1.\u3000\u5168\u30b2\u30ce\u30e0\u5869\u57fa\u914d\u5217\u6c7a\u5b9a\u300d<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">CC BY<\/a><\/p>\n\n\n\n<p class=\"has-text-align-right\"><a href=\"#toc_container\">\u76ee\u6b21\u30da\u30fc\u30b8\u3078\u2191<\/a><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div><\/section>\n\n\n\n<section id=\"section-2\" class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h3 class=\"wp-block-heading\">2.\u3000GFP\u3068G-CaMP<\/h3>\n\n\n\n<h4 class=\"wp-block-heading has-text-align-left\">GFP\u3068\u306f<\/h4>\n\n\n\n<p>\u3000\u7dd1\u8272\u86cd\u5149\u30bf\u30f3\u30d1\u30af\u8cea\uff08Green Fluorescent Protein: \u7565\u3057\u3066GFP\uff09\u306f\u3001\u30aa\u30ef\u30f3\u30af\u30e9\u30b2\u3068\u3044\u3046\u6d77\u6d0b\u751f\u7269\u304b\u3089\u767a\u898b\u3055\u308c\u305f\u5149\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3059\u3002\u30aa\u30ef\u30f3\u30af\u30e9\u30b2\u306f\u305d\u306e\u540d\u306e\u901a\u308a\u3001\u304a\u6900\u3092\u9006\u3055\u306b\u3057\u305f\u3088\u3046\u306a\u5f62\u3092\u3057\u3066\u304a\u308a\u3001\u523a\u6fc0\u3092\u53d7\u3051\u308b\u3068\u4f53\u306e\u5468\u308a\u304c\u7f8e\u3057\u3044\u7dd1\u8272\u306b\u5149\u308a\u307e\u3059\u3002\u4e0b\u6751\u8129\u535a\u58eb\u306f\u300c\u30af\u30e9\u30b2\u304c\u306a\u305c\u5149\u308b\u306e\u304b\u300d\u3068\u3044\u3046\u7d14\u7c8b\u306a\u7591\u554f\u304b\u3089\u7814\u7a76\u3092\u59cb\u3081\u30011962\u5e74\u306b\u5927\u91cf\u306e\u30aa\u30ef\u30f3\u30af\u30e9\u30b2\u304b\u3089GFP\u3092\u7cbe\u88fd\u3059\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002<br>\u3000GFP\u306f238\u500b\u306e\u30a2\u30df\u30ce\u9178\u304b\u3089\u306a\u308b\u5186\u7b52\u5f62\u306e\u69cb\u9020\u3092\u6301\u3061\u3001\u305d\u306e\u4e2d\u5fc3\u306b\u3042\u308b\u767a\u8272\u56e3\u3068\u547c\u3070\u308c\u308b\u90e8\u5206\u304c\u9752\u3044\u5149\u3092\u5438\u53ce\u3057\u3001\u7dd1\u8272\u306e\u5149\uff08\u86cd\u5149\uff09\u3092\u653e\u51fa\u3057\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306b\u3001\u5149\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u5438\u53ce\u3057\u3066\u5225\u306e\u8272\u306e\u86cd\u5149\u3092\u653e\u51fa\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u86cd\u5149\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u547c\u3073\u307e\u3059\u3002<br>\u3000\u3053\u3053\u3067\u3001\u30aa\u30ef\u30f3\u30af\u30e9\u30b2\u306eGFP\u306e\u86cd\u5149\u3068\u30db\u30bf\u30eb\u306e\u5149\u3068\u306e\u9055\u3044\u306b\u3064\u3044\u3066\u8aac\u660e\u3057\u307e\u3059\u3002\u30db\u30bf\u30eb\u306e\u5149\u306f\u300c\u5316\u5b66\u767a\u5149\u300d\u3068\u547c\u3070\u308c\u3001\u767a\u5149\u57fa\u8cea\u3068\u305d\u308c\u3092\u89e6\u5a92\u3059\u308b\u9175\u7d20\u3068\u306e\u5316\u5b66\u53cd\u5fdc\u306b\u3088\u3063\u3066\u751f\u3058\u307e\u3059\u3002\u4e00\u65b9\u3001GFP\u306f\u5149\u3092\u5f53\u3066\u308b\u3060\u3051\u3067\u86cd\u5149\u3092\u767a\u3057\u3001\u9175\u7d20\u3084\u57fa\u8cea\u3092\u5fc5\u8981\u3068\u3057\u307e\u305b\u3093\u3002\u3053\u306e\u7279\u6027\u306b\u3088\u308a\u3001GFP\u306f\u751f\u7269\u5b66\u306e\u7814\u7a76\u306b\u304a\u3044\u3066\u975e\u5e38\u306b\u4fbf\u5229\u306a\u30c4\u30fc\u30eb\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img decoding=\"async\" width=\"1024\" height=\"525\" src=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/06\/229ff8f9ddb65de652048107260db295-1024x525.jpg\" alt=\"\" class=\"wp-image-1065\" style=\"width:604px;height:auto\" srcset=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/06\/229ff8f9ddb65de652048107260db295-1024x525.jpg 1024w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/06\/229ff8f9ddb65de652048107260db295-300x154.jpg 300w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/06\/229ff8f9ddb65de652048107260db295-768x394.jpg 768w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/06\/229ff8f9ddb65de652048107260db295-670x344.jpg 670w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/06\/229ff8f9ddb65de652048107260db295.jpg 1158w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"has-text-align-right has-small-font-size\">Illustrated by Hiroko Uchida&nbsp;<\/p>\n\n\n\n<h4 class=\"wp-block-heading has-text-align-left\">GFP\u3092\u4f7f\u3063\u3066\u751f\u304d\u305f\u7d30\u80de\u3092\u300c\u8996\u308b\u300d<\/h4>\n\n\n\n<p>\u3000GFP\u3092\u4f7f\u3048\u3070\u751f\u304d\u7269\u306b\u5bb3\u3092\u4e0e\u3048\u305a\u306b\u3001\u7d30\u80de\u3084\u7d30\u80de\u5185\u306e\u5206\u5b50\u306e\u52d5\u304d\u3092\u751f\u304d\u305f\u307e\u307e\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u3067\u89b3\u5bdf\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u30021990\u5e74\u4ee3\u306b\u306f\u3001GFP\u306e\u86cd\u5149\u3092\u76ee\u5370\u3068\u3057\u3066\u751f\u304d\u7269\u306e\u4e2d\u306e\u7279\u5b9a\u306e\u7d30\u80de\u3084\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u89b3\u5bdf\u3059\u308b\u65b9\u6cd5\u304c\u958b\u767a\u3055\u308c\u307e\u3057\u305f\u3002\u6700\u521d\u306b\u8a66\u3055\u308c\u305f\u306e\u304c\u3001\u7dda\u866b\u3068\u3044\u3046\u5c0f\u3055\u306a\u52d5\u7269\u3067\u3059\u3002\u7dda\u866b\u306f\u4f53\u5168\u4f53\u304c\u900f\u660e\u3067\u3042\u308a\u3001\u751f\u304d\u305f\u307e\u307e\u4f53\u5185\u306e\u69cb\u9020\u3084\u500b\u3005\u306e\u7d30\u80de\u3092\u76f4\u63a5\u89b3\u5bdf\u3067\u304d\u307e\u3059\u3002\u30de\u30fc\u30c6\u30a3\u30f3\u30fb\u30c1\u30e3\u30eb\u30d5\u30a3\u535a\u58eb\u306f\u907a\u4f1d\u5b50\u5de5\u5b66\u3092\u5229\u7528\u3057\u3066\u3001GFP\u3092\u4f5c\u308b\u907a\u4f1d\u5b50\u3092\u7dda\u866b\u306b\u7d44\u307f\u8fbc\u307f\u3001\u751f\u304d\u305f\u7dda\u866b\u306e\u4e2d\u3067\u89e6\u899a\uff08\u3055\u308f\u3063\u305f\u611f\u899a\uff09\u306e\u795e\u7d4c\u7d30\u80de\u3060\u3051\u3092\u7dd1\u8272\u306b\u5149\u3089\u305b\u308b\u3053\u3068\u306b\u4e16\u754c\u3067\u521d\u3081\u3066\u6210\u529f\u3057\u307e\u3057\u305f\uff08\uff11\uff09\u3002GFP\u3092\u76ee\u5370\u306b\u7279\u5b9a\u306e\u305f\u3093\u3071\u304f\u8cea\u304c\u7d30\u80de\u5185\u3067\u3069\u306e\u3088\u3046\u306b\u5c40\u5728\u3057\u3066\u3044\u308b\u304b\u3092\u89b3\u5bdf\u3057\u3001\u6642\u9593\u3068\u3068\u3082\u306b\u5909\u5316\u3059\u308b\u69d8\u5b50\u3092\u8ffd\u8de1\u3067\u304d\u307e\u3059\u3002\u307e\u305f\u3001GFP\u306f\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u3082\u5229\u7528\u3055\u308c\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u304c\u50cd\u304f\u5834\u6240\u3084\u30bf\u30a4\u30df\u30f3\u30b0\u3092\u8abf\u3079\u308b\u3053\u3068\u3082\u3067\u304d\u307e\u3059\u3002\u6700\u8fd1\u3001\u7dd1\u8272\u306e\u4ed6\u306b\u3082\u3001\u8d64\u8272\u86cd\u5149\u30bf\u30f3\u30d1\u30af\u8cea\u306a\u3069\u3055\u307e\u3056\u307e\u306a\u8272\u306e\u86cd\u5149\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u958b\u767a\u3055\u308c\u3001\u8907\u6570\u306e\u7d30\u80de\u3084\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u540c\u6642\u306b\u89e3\u6790\u3059\u308b\u3053\u3068\u3082\u53ef\u80fd\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u73fe\u5728\u3001GFP\u306f\u751f\u547d\u79d1\u5b66\u3084\u533b\u5b66\u306e\u7814\u7a76\u306e\u3055\u307e\u3056\u307e\u5206\u91ce\u3067\u5229\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002GFP\u306e\u767a\u898b\u3068\u5fdc\u7528\u306b\u3088\u3063\u3066\u3001\u4e0b\u6751\u535a\u58eb\u3001\u30c1\u30e3\u30eb\u30d5\u30a3\u30fc\u535a\u58eb\u3001\u30c1\u30a8\u30f3\u535a\u58eb\u306f2008\u5e74\u306b\u30ce\u30fc\u30d9\u30eb\u5316\u5b66\u8cde\u3092\u53d7\u8cde\u3057\u307e\u3057\u305f\u3002GFP\u5b9f\u9a13\u306f\u3001\u9ad8\u6821\u3084\u5927\u5b66\u3067\u884c\u308f\u308c\u308b\u590f\u306e\u5b66\u6821\u3084\u7279\u5225\u30d7\u30ed\u30b0\u30e9\u30e0\u3067\u3082\u5e83\u304f\u63a1\u7528\u3055\u308c\u3066\u304a\u308a\u3001\u305d\u306e\u8996\u899a\u7684\u306a\u9b45\u529b\u3068\u5fdc\u7528\u53ef\u80fd\u6027\u306f\u3001\u6700\u5148\u7aef\u6280\u8853\u3068\u79d1\u5b66\u3078\u306e\u8208\u5473\u3092\u5f15\u304d\u51fa\u3059\u7d20\u6674\u3089\u3057\u3044\u984c\u6750\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">G-CaMP\u3068\u30ab\u30eb\u30b7\u30a6\u30e0\u30a4\u30aa\u30f3\u306e\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0<\/h4>\n\n\n\n<p>\u3000\u30ab\u30eb\u30b7\u30a6\u30e0\u30a4\u30aa\u30f3\uff08Ca<sup>2+<\/sup>\uff09\u306f\u3001\u795e\u7d4c\u306e\u6d3b\u52d5\u3084\u7b4b\u8089\u306e\u53ce\u7e2e\u3001\u30db\u30eb\u30e2\u30f3\u306e\u5206\u6ccc\u306a\u3069\u3001\u79c1\u305f\u3061\u306e\u4f53\u3067\u591a\u304f\u306e\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u30d7\u30ed\u30bb\u30b9\u306f\u3059\u3079\u3066\u3001\u7d30\u80de\u5185Ca<sup>2+<\/sup>\u6fc3\u5ea6\u306e\u5fae\u7d30\u306a\u5909\u5316\u306b\u3088\u3063\u3066\u8abf\u7bc0\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001Ca<sup>2+<\/sup>\u6fc3\u5ea6\u306e\u5909\u5316\u3092\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u3067\u89b3\u5bdf\u3059\u308b\uff08\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3059\u308b\uff09\u3053\u3068\u306f\u3001\u751f\u547d\u73fe\u8c61\u3084\u75c5\u6c17\u3092\u7406\u89e3\u3059\u308b\u4e0a\u3067\u975e\u5e38\u306b\u91cd\u8981\u3067\u3059\u3002G-CaMP\uff08\u30b8\u30fc\u30ad\u30e3\u30f3\u30d7\uff09\u306f\u3001\u7d30\u80de\u5185\u306eCa<sup>2+<\/sup>\u6fc3\u5ea6\u3092\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3059\u308b\u305f\u3081\u306b\u4e2d\u4e95\u6df3\u4e00\u535a\u58eb\u3089\u306b\u3088\u3063\u3066\u958b\u767a\u3055\u308c\u305fGFP\u30d9\u30fc\u30b9\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u30bb\u30f3\u30b5\u30fc\u3067\u3059\uff08\uff12\uff09\u3002\u3053\u306e\u30bb\u30f3\u30b5\u30fc\u306f\u3001\u6539\u5909\u3055\u308c\u305fGFP\uff08cpGFP\uff09\u3001\u30ab\u30eb\u30e2\u30b8\u30e5\u30ea\u30f3(CaM)\u3001\u304a\u3088\u3073\u30df\u30aa\u30b7\u30f3\u8efd\u9396\u30ad\u30ca\u30fc\u30bc\uff08M13\uff09\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u69cb\u9020\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002Ca<sup>2+<\/sup>\u304c\u30ab\u30eb\u30e2\u30b8\u30e5\u30ea\u30f3\u306b\u7d50\u5408\u3059\u308b\u3068\u3001Ca<sup>2+<\/sup>\u30fb\u30ab\u30eb\u30e2\u30b8\u30e5\u30ea\u30f3\u8907\u5408\u4f53\u304cM13\u3068\u7d50\u5408\u3057\u3001cpGFP\u306e\u7acb\u4f53\u69cb\u9020\u3092\u5909\u5316\u3055\u305b\u3066\u86cd\u5149\u304c\u660e\u308b\u304f\u306a\u308a\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u795e\u7d4c\u3084\u7b4b\u8089\u304c\u6d3b\u52d5\u3057\u3066Ca<sup>2+<\/sup>\u6fc3\u5ea6\u304c\u9ad8\u304f\u306a\u308b\u3068G-CaMP\u304c\u660e\u308b\u304f\u5149\u308b\u3088\u3046\u306b\u306a\u308b\u4ed5\u7d44\u307f\u3067\u3059\u3002\u3053\u306e\u6280\u8853\u306f\u795e\u7d4c\u79d1\u5b66\u306e\u5206\u91ce\u3067\u7279\u306b\u5229\u7528\u3055\u308c\u3066\u304a\u308a\u3001\u52d5\u7269\u306e\u795e\u7d4c\u7cfb\u306e\u50cd\u304d\u3092\u751f\u304d\u305f\u307e\u307e\u300c\u8996\u308b\u300d\u3053\u3068\u304c\u3067\u304d\u308b\u306e\u3067\u3059\u3002\u4f8b\u3048\u3070\u3001\u7dda\u866b\u306f\u597d\u304d\u306a\u6e29\u5ea6\u3084\u5316\u5b66\u7269\u8cea\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u305d\u308c\u3089\u306e\u523a\u6fc0\u306b\u5bfe\u3059\u308b\u611f\u899a\u795e\u7d4c\u56de\u8def\u306e\u5fdc\u7b54\u3084\u3001\u884c\u52d5\u306b\u95a2\u9023\u3059\u308b\u795e\u7d4c\u6d3b\u52d5\u3092\u8a73\u7d30\u306b\u89e3\u6790\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3000\u3053\u306e\u3088\u3046\u306b\u3001GFP\u3068G-CaMP\u306f\u3055\u307e\u3056\u307e\u306a\u751f\u7269\u5b66\u7684\u30d7\u30ed\u30bb\u30b9\u3092\u53ef\u8996\u5316\u3057\u3001\u751f\u547d\u79d1\u5b66\u7814\u7a76\u306b\u304a\u3044\u3066\u5f37\u529b\u306a\u30c4\u30fc\u30eb\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u53c2\u8003\u8cc7\u6599<\/strong><br>1\uff09Chalfie M, Tu Y, Euskirchen G, Ward WW, Prasher DC. Green fluorescent protein as a marker for gene expression. Science. 1994 Feb 11;263(5148):802-5. doi: 10.1126\/science.8303295. PMID: 8303295.<br>2)   Nakai J, Ohkura M, Imoto K. A high signal-to-noise Ca(2+) probe composed of a single green fluorescent protein. Nat Biotechnol. 2001 Feb;19(2):137-41. doi: 10.1038\/84397. PMID: 11175727.<\/p>\n\n\n\n<p><strong>\u76e3\u4fee\u8005<\/strong><br>\u5b89\u85e4\u3000\u6075\u5b50<br>\u5cf6\u6839\u770c\u751f\u307e\u308c\u3001\u5ca1\u5c71\u5927\u5b66\u7406\u5b66\u90e8\u5352\u696d\u3001\u540c\u5927\u5b66\u9662\u535a\u58eb\u8ab2\u7a0b\u4fee\u4e86\u3002\u6771\u5317\u5927\u5b66\u6b6f\u5b66\u7814\u7a76\u79d1\u51c6\u6559\u6388\u3002\u7dda\u866b\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u7d30\u80de\u5185\u306e\u7269\u6d41\u30b7\u30b9\u30c6\u30e0\u3084\u795e\u7d4c\u7cfb\u3067\u306e\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u306e\u5206\u6ccc\u3092\u62c5\u3046\u907a\u4f1d\u5b50\u306e\u7814\u7a76\u3001\u304a\u3088\u3073\u95a2\u9023\u3059\u308b\u75be\u60a3\u30e2\u30c7\u30eb\u52d5\u7269\u306e\u958b\u767a\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u308b\u3002<\/p>\n\n\n\n<p class=\"has-text-align-right has-small-font-size\">\u00a92026 \u5b89\u85e4\u6075\u5b50\u300c2.\u3000GFP\u3068G-CaMP\u300d<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">CC BY<\/a><\/p>\n\n\n\n<p class=\"has-text-align-right\"><a href=\"#toc_container\">\u76ee\u6b21\u30da\u30fc\u30b8\u3078\u2191<\/a><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div><\/section>\n\n\n\n<section id=\"section-3\" class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h3 class=\"wp-block-heading\">3.\u3000RNA\u5e72\u6e09\u3068\u30de\u30a4\u30af\u30edRNA<\/h3>\n\n\n\n<h4 class=\"wp-block-heading\">RNA\u5e72\u6e09\u3068\u30de\u30a4\u30af\u30edRNA<\/h4>\n\n\n\n<p>\u3000RNA\u5e72\u6e09\uff08RNAi\uff09\u7d4c\u8def\u3084\u30de\u30a4\u30af\u30edRNA\uff08miRNA\uff09\u7d4c\u8def\u306f\u3001\u5c0f\u3055\u306a\u30b5\u30a4\u30ba\u306eRNA\u3092\u4f7f\u3063\u3066\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3059\u308b\u3082\u306e\u3067\u3001\u751f\u304d\u7269\u304c\u751f\u304d\u3066\u3044\u304f\u305f\u3081\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002\u7dda\u866b\uff08<em>C. elegans<\/em>\uff09\u7814\u7a76\u8005\u306f\u3001\u3053\u308c\u3089\u306e\u7814\u7a76\u306e\u30d1\u30a4\u30aa\u30cb\u30a2\u3067\u3042\u308a\u30012006\u5e74\u306b\u306f\u30a2\u30f3\u30c9\u30ea\u30e5\u30fc\u30fb\u30d5\u30a1\u30a4\u30a2\u30fc\uff08Andrew Fire\uff09\u3068\u30af\u30ec\u30a4\u30b0\u30fb\u30e1\u30ed\u30fc\uff08Craig Mello\uff09\u304cRNA\u5e72\u6e09\u306b\u95a2\u3059\u308b\u767a\u898b\u3067\u30012024\u5e74\u306b\u30f4\u30a3\u30af\u30bf\u30fc\u30fb\u30a2\u30f3\u30d6\u30ed\u30b9\uff08Victor Ambros\uff09\u3068\u30b2\u30a4\u30ea\u30fc\u30fb\u30e9\u30f4\u30ab\u30f3\uff08Gary Ruvkun\uff09\u304c\u30de\u30a4\u30af\u30edRNA\u306b\u95a2\u3059\u308b\u767a\u898b\u3067\u3001\u305d\u308c\u305e\u308c\u30ce\u30fc\u30d9\u30eb\u751f\u7406\u5b66\u30fb\u533b\u5b66\u8cde\u3092\u53d7\u8cde\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u751f\u304d\u7269\u306e\u907a\u4f1d\u60c5\u5831\u306f\u3001DNA\u3068\u3044\u3046\u5206\u5b50\u306b\u66f8\u304d\u8fbc\u307e\u308c\u3066\u304a\u308a\u3001\u9069\u5207\u306a\u30bf\u30a4\u30df\u30f3\u30b0\u3068\u5834\u6240\u3067\u907a\u4f1d\u60c5\u5831\u306e\u4e00\u90e8\u304c\u30e1\u30c3\u30bb\u30f3\u30b8\u30e3\u30fcRNA(mRNA)\u306b\u30b3\u30d4\u30fc\u3055\u308c\uff08\u8ee2\u5199\uff09\u3001\u305d\u306e\u60c5\u5831\u3092\u3082\u3068\u306b\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u4f5c\u3089\u308c\u307e\u3059\uff08\u7ffb\u8a33\uff09\u3002\u907a\u4f1d\u60c5\u5831\u3092\u3082\u3068\u306b\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u4f5c\u3089\u308c\u308b\u3053\u3068\u3092\u907a\u4f1d\u5b50\u767a\u73fe\u3068\u3044\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u300cDNA\u2192mRNA\u300d\u306e\u30d7\u30ed\u30bb\u30b9\u3067\u306f\u3001\u4e3b\u306b\u8ee2\u5199\u56e0\u5b50\u3068\u3044\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u4fc3\u9032\u3084\u6291\u5236\u306e\u5236\u5fa1\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u304c\u3001RNA\u5e72\u6e09\u3084\u30de\u30a4\u30af\u30edRNA\u306e\u30b7\u30b9\u30c6\u30e0\u306f\u3001\u300cmRNA\u2192\u30bf\u30f3\u30d1\u30af\u8cea\u5408\u6210\u300d\u306e\u30d7\u30ed\u30bb\u30b9\u3092\u59a8\u3052\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u6291\u5236\uff08\u30b5\u30a4\u30ec\u30f3\u30b7\u30f3\u30b0\uff09\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"832\" src=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/06\/fc261a6576a2bdf28b04f7622cd00733-1024x832.png\" alt=\"\" class=\"wp-image-1067\" srcset=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/06\/fc261a6576a2bdf28b04f7622cd00733-1024x832.png 1024w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/06\/fc261a6576a2bdf28b04f7622cd00733-300x244.png 300w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/06\/fc261a6576a2bdf28b04f7622cd00733-768x624.png 768w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/06\/fc261a6576a2bdf28b04f7622cd00733-670x545.png 670w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/06\/fc261a6576a2bdf28b04f7622cd00733.png 1240w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"has-text-align-right has-small-font-size\">Illustrated by Hiroko Uchida&nbsp;<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">RNA\u5e72\u6e09<\/h4>\n\n\n\n<p>\u3000RNA\u5e72\u6e09\u306f\u3001small interfering RNAs (siRNAs)\u3068\u3044\u3046\u77ed\u3044\u4e8c\u672c\u9396RNA\u304c\u3001\u76f8\u88dc\u7684\u306a\u914d\u5217\u3092\u3082\u3064\u30bf\u30fc\u30b2\u30c3\u30c8RNA\u306b\u7d50\u5408\u3057\u3001\u305d\u306e\u30bf\u30fc\u30b2\u30c3\u30c8RNA\u3092\u5206\u89e3\u3059\u308b\u30b7\u30b9\u30c6\u30e0\u3067\u3059\u3002siRNA\u306f\u57fa\u672c\u7684\u306b\u5916\u6765\u3067\u3001RNA\u5e72\u6e09\u306f\u3001\u5916\u6765\u306e\u30a6\u30a4\u30eb\u30b9\u3084DNA\u4e0a\u3092\u52d5\u304d\u56de\u308b\u80fd\u529b\u3092\u3082\u3064\u907a\u4f1d\u5b50\uff08transposable elements\uff09\u306a\u3069\u304b\u3089\u751f\u4f53\u3092\u9632\u5fa1\u3059\u308b\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304d\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>RNA\u5e72\u6e09\u306f\u30011998\u5e74\u306b\u521d\u3081\u3066\u767a\u8868\u3055\u308c\u3066\u4ee5\u964d\u3001\u7814\u7a76\u5bfe\u8c61\u3068\u306a\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u751f\u7269\u5b66\u306e\u91cd\u8981\u306a\u30c4\u30fc\u30eb\u3068\u3057\u3066\u5927\u6d3b\u8e8d\u3057\u3066\u3044\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u3042\u308b\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u6291\u3048\u308b\u3068\u3069\u3046\u306a\u308b\u306e\u304b\u3092\u898b\u305f\u3044\u3068\u304d\u306b\u306f\u3001\u72d9\u3063\u305f\u907a\u4f1d\u5b50DNA\u304b\u3089\u8ee2\u5199\u3055\u308c\u308bmRNA\u306e\u914d\u5217\u306b\u3042\u308f\u305b\u3066siRNA\u3092\u4eba\u5de5\u7684\u306b\u5408\u6210\u3057\u3001\u7d30\u80de\u3084\u500b\u4f53\u306b\u53d6\u308a\u8fbc\u307e\u305b\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u305d\u306e\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u4eba\u70ba\u7684\u306b\u6291\u3048\u308b\u3053\u3068\uff08\u30ce\u30c3\u30af\u30c0\u30a6\u30f3\uff09\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7dda\u866b\u306e\u7814\u7a76\u3067\u306f\u3001siRNA\u306e\u524d\u6bb5\u968e\u306edsRNA\uff08double-stranded RNA\uff09\u3092\u4f7f\u3044\u307e\u3059\u304c\u3001dsRNA\u3092\u2460\u6ce8\u5c04\u3059\u308b\u3001\u2461\u98df\u3079\u3055\u305b\u308b\u3001\u2462\u542b\u307e\u305b\u305f\u6db2\u4f53\u306b\u6d78\u3051\u308b\u3001\u3068\u3044\u3063\u305f\u65b9\u6cd5\u3067\u53d6\u308a\u8fbc\u307e\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u3001RNA\u5e72\u6e09\u306e\u52b9\u679c\u306f\u4e16\u4ee3\u3092\u8d85\u3048\u3066\u5f15\u304d\u7d99\u304c\u308c\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"972\" height=\"456\" src=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/06\/b3a0ade3caca0c2ca484ce59e8136380.png\" alt=\"\" class=\"wp-image-1066\" srcset=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/06\/b3a0ade3caca0c2ca484ce59e8136380.png 972w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/06\/b3a0ade3caca0c2ca484ce59e8136380-300x141.png 300w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/06\/b3a0ade3caca0c2ca484ce59e8136380-768x360.png 768w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/06\/b3a0ade3caca0c2ca484ce59e8136380-670x314.png 670w\" sizes=\"(max-width: 972px) 100vw, 972px\" \/><\/figure>\n\n\n\n<p class=\"has-text-align-right has-small-font-size\">Illustrated by Hiroko Uchida&nbsp;<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u30de\u30a4\u30af\u30edRNA<\/h4>\n\n\n\n<p>\u3000\u30de\u30a4\u30af\u30edRNA\u306f\u3001DNA\u306b\u66f8\u304d\u8fbc\u307e\u308c\u305f\u907a\u4f1d\u60c5\u5831\u3092\u3082\u3068\u306b\u77ed\u3044\u4e00\u672c\u9396RNA\u5206\u5b50\u3068\u3057\u3066\u4f5c\u3089\u308c\u3001\u9175\u7d20\u53cd\u5fdc\u306b\u3088\u308a\u6210\u719f\u3057\u3001\u76f8\u88dc\u7684\u306a\u914d\u5217\u3092\u3082\u3064\u30bf\u30fc\u30b2\u30c3\u30c8mRNA\u3092\u5206\u89e3\u3057\u305f\u308a\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u3078\u306e\u7ffb\u8a33\u3092\u59a8\u3052\u307e\u3059\u3002\u521d\u3081\u3066\u767a\u898b\u3055\u308c\u305f\u30de\u30a4\u30af\u30edRNA\u306e\u907a\u4f1d\u5b50\uff08lin-4\uff09\u3068\u305d\u306e\u30bf\u30fc\u30b2\u30c3\u30c8mRNA\u306e\u907a\u4f1d\u5b50\uff08lin-14\uff09\u306f\u3001\u7dda\u866b\u306e\u6210\u9577\u306b\u7570\u5e38\u3092\u793a\u3059\u907a\u4f1d\u5b50\u5909\u7570\u4f53\u306e\u89e3\u6790\u304b\u3089\u767a\u898b\u3055\u308c\u307e\u3057\u305f\u3002\u5909\u7570\u4f53\u3068\u306f\u3001\u907a\u4f1d\u5b50\u306e\u4e00\u90e8\u306b\u50b7\u3092\u3082\u3064\u500b\u4f53\u3067\u3059\u3002\u7dda\u866b\u306f\u3001\u907a\u4f1d\u5b50\u3092\u64cd\u4f5c\u3057\u3066\u751f\u547d\u73fe\u8c61\u306e\u8b0e\u3092\u89e3\u660e\u3059\u308b\u907a\u4f1d\u5b66\u7684\u89e3\u6790\u306b\u5927\u304d\u306a\u5f37\u307f\u3092\u3082\u3061\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u7814\u7a76\u306f\u3001lin-4\u907a\u4f1d\u5b50\u304c\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u306f\u306a\u304fRNA\u3068\u3057\u3066lin-14\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u5236\u5fa1\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u9a5a\u304d\u3092\u4e0e\u3048\u307e\u3057\u305f\u3002\u305d\u306e\u5f8c\u306e\u7814\u7a76\u304b\u3089\u3001\u3055\u307e\u3056\u307e\u306a\u30de\u30a4\u30af\u30edRNA\u304c\u767a\u898b\u3055\u308c\u3001\u767a\u751f\u3084\u6210\u9577\u306e\u6642\u671f\u3084\u7d44\u7e54\u306b\u3042\u308f\u305b\u3066\u9069\u5207\u306a\u30bf\u30a4\u30df\u30f3\u30b0\u3068\u5834\u6240\u3067\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3059\u308b\u3053\u3068\u3001\u30d2\u30c8\u3092\u542b\u3080\u3055\u307e\u3056\u307e\u306a\u751f\u7269\u3067\u767a\u751f\u3084\u75be\u60a3\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u304d\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>RNA\u5e72\u6e09\u3084\u30de\u30a4\u30af\u30edRNA\u306f\u3001\u533b\u7642\u306e\u5206\u91ce\u3067\u3082\u6ce8\u76ee\u3055\u308c\u3066\u304d\u3066\u3044\u307e\u3059\u3002\u5f93\u6765\u7528\u3044\u3089\u308c\u3066\u304d\u305f\u5316\u5408\u7269\u3084\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u7528\u3044\u305f\u6cbb\u7642\u306e\u591a\u304f\u3067\u306f\u3001\u75c5\u6c17\u306e\u3082\u3068\u306b\u306a\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3057\u3066\u3044\u307e\u3059\u304c\u3001RNA\u5e72\u6e09\u3084\u30de\u30a4\u30af\u30edRNA\u306e\u30b7\u30b9\u30c6\u30e0\u3092\u5fdc\u7528\u3059\u308c\u3070\u3001\u539f\u56e0\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4f5c\u3089\u305b\u306a\u3044\u6cbb\u7642\u6cd5\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002\u3068\u306f\u3044\u3048\u3001\u672c\u6765\u306e\u30bf\u30fc\u30b2\u30c3\u30c8\u3060\u3051\u306b\u4f5c\u7528\u3059\u308b\u304b\u3001\u526f\u4f5c\u7528\u306f\u306a\u3044\u304b\u3001\u4e16\u4ee3\u3092\u3053\u3048\u305f\u5f71\u97ff\u306f\u306a\u3044\u304b\u3001\u306a\u3069\u8ab2\u984c\u3082\u591a\u304f\u3001\u4eca\u5f8c\u307e\u3059\u307e\u3059\u306e\u7814\u7a76\u306e\u767a\u5c55\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u53c2\u8003\u8cc7\u6599<\/strong><br>1\uff09Sydney Brenner\u8457\u3000\u300cThe genetics of Caenorhabditis elegans\u300d\u30011974\u5e74\u3000Genetics, 77: 71-94\u3001doi: 10.1093\/genetics\/77.1.71<\/p>\n\n\n\n<p>2\uff09R.C. Lee, R.L. Feinbaum, V. Ambros\u8457\u3000\u300cThe C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14\u300d\u30011993\u5e74\u3000Cell, 75: 843-54\u3001doi: 10.1016\/0092-8674(93)90529-y<br><\/p>\n\n\n\n<p><strong>\u76e3\u4fee\u8005<\/strong><br>\u5742\u53e3\u3000\u611b\u6c99<\/p>\n\n\n\n<p class=\"has-text-align-right has-small-font-size\">\u00a92026 \u866b\u306e\u96c6\u3044\uff08\u7dda\u866b\u7814\u7a76\u8005\u30b3\u30df\u30e5\u30cb\u30c6\u30a3\uff09\u300c3.\u3000RNA\u5e72\u6e09\u3068\u30de\u30a4\u30af\u30edRNA\u300d<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">CC BY<\/a><\/p>\n\n\n\n<p class=\"has-text-align-right\"><a href=\"#toc_container\">\u76ee\u6b21\u30da\u30fc\u30b8\u3078\u2191<\/a><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div><\/section>\n\n\n\n<section id=\"section-4\" class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h3 class=\"wp-block-heading\">4.\u3000\u7dda\u866b\u306b\u304a\u3051\u308b\u5168\u8133\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0<\/h3>\n\n\n\n<h4 class=\"wp-block-heading has-text-align-left\">\u5168\u8133\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3068\u306f\uff1f<\/h4>\n\n\n\n<p>\u3000\u30d2\u30c8\u306e\u8133\u306f\u3001\u7d041500 cm<sup>3<\/sup>\u306e\u5927\u304d\u306a\u69cb\u9020\u3067\u3001\u305d\u306e\u4e2d\u306b1000\u5104\u500b\u3092\u8d85\u3048\u308b\u6570\u306e\u795e\u7d4c\u7d30\u80de\u304c\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u3092\u3064\u304f\u3063\u3066\u3001\u60c5\u5831\u51e6\u7406\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u5168\u4f53\u306e\u306f\u305f\u3089\u304d\u306f\u3001\uff46MRI\uff08\u78c1\u6c17\u5171\u9cf4\u6a5f\u80fd\u753b\u50cf\u6cd5\uff09\u3067\u77e5\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u3053\u306e\u624b\u6cd5\u3067\u306f\u3001\u8133\u5168\u4f53\u3092\u5c0f\u3055\u306a\u9818\u57df\uff08\u6700\u3082\u5c0f\u3055\u304f\u3066\u7d041 mm<sup>3<\/sup>\uff09\u306b\u308f\u3051\u3066\u3001\u305d\u308c\u305e\u308c\u306e\u8840\u6d41\u3084\u9178\u7d20\u4ee3\u8b1d\u3092\u6e2c\u5b9a\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u8133\u306e\u9818\u57df\u3054\u3068\u306e\u6d3b\u52d5\u3092\u63a8\u6e2c\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u308c\u3067\u3082\u795e\u7d4c\u7d30\u80de\u3072\u3068\u3064\u305a\u3064\u306e\u6d3b\u52d5\u3092\u8abf\u3079\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u3001\u3082\u30570.01 mm\u7a0b\u5ea6\u306e\u5927\u304d\u3055\u306e\u795e\u7d4c\u7d30\u80de\u306e\u3059\u3079\u3066\u306b\u3064\u3044\u3066\u500b\u5225\u306b\u6d3b\u52d5\u3092\u8a08\u6e2c\u3067\u304d\u308c\u3070\u3001\u5b9f\u969b\u306e\u60c5\u5831\u51e6\u7406\u306e\u3088\u3046\u3059\u3092\u77e5\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u7dda\u866b\u306e\u300c\u8133\u300d\u306b\u3042\u305f\u308b\u982d\u90e8\u306e\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306f\u3001\u7d04180\u500b\u306e\u795e\u7d4c\u7d30\u80de\u304c\u3001\u592a\u3055\u304c\u9aea\u306e\u6bdb\u304f\u3089\u3044\uff08\u76f4\u5f840.05 mm\uff09\u3067\u9577\u3055\u304c0.25 mm\u304f\u3089\u3044\u306e\u5c0f\u3055\u306a\u9818\u57df\u306b\u307e\u3068\u307e\u3063\u3066\u3044\u307e\u3059\u3002\u7dda\u866b\u3067\u306f\u3001\u3053\u306e\u7279\u5fb4\u3092\u6d3b\u304b\u3057\u3066\u3001\u300c\u5168\u8133\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u300d\u3068\u547c\u3070\u308c\u308b\u65b9\u6cd5\u3067\u3001\u8133\u306e\u5168\u3066\u306e\u795e\u7d4c\u7d30\u80de\u3092\u3072\u3068\u3064\u305a\u3064\u6e2c\u5b9a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3000\u3053\u306e\u5927\u304d\u3055\u306a\u3089\u3001\u9855\u5fae\u93e1\u3067\u9ad8\u500d\u7387\u306e\u5bfe\u7269\u30ec\u30f3\u30ba\u3092\u4f7f\u3048\u3070\u3001\u8133\u5168\u4f53\u306e\u795e\u7d4c\u7d30\u80de\u3092\u3072\u3068\u3064\u305a\u3064\u89b3\u5bdf\u3067\u304d\u307e\u3059\u3002\u795e\u7d4c\u7d30\u80de\u306e\u306f\u305f\u3089\u304d\u3092\u500b\u5225\u306b\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u305d\u306e\u4e00\u3064\u4e00\u3064\u306e\u6d3b\u52d5\u306e\u5909\u5316\u3092\u6e2c\u5b9a\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u795e\u7d4c\u7d30\u80de\u306f\u3001\u4e3b\u306b\u96fb\u6c17\u4fe1\u53f7\u3092\u4f1d\u3048\u3066\u3044\u308b\u306e\u3067\u3001\u795e\u7d4c\u7d30\u80de\u306e\u6d3b\u52d5\u3092\u6e2c\u5b9a\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u96fb\u6c17\u4fe1\u53f7\u3068\u96fb\u6975\u3092\u4f7f\u3063\u3066\u6e2c\u5b9a\u3059\u308b\u65b9\u6cd5\uff08\u96fb\u6c17\u751f\u7406\u5b66\uff09\u304c\u6614\u304b\u3089\u4f7f\u308f\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u7dda\u866b\u306e\u8133\u306f\u3068\u3066\u3082\u5c0f\u3055\u3044\u306e\u3067\u3001\u305d\u308c\u305e\u308c\u306e\u795e\u7d4c\u7d30\u80de\u306e\u96fb\u6c17\u4fe1\u53f7\u3092\u76f4\u63a5\u6e2c\u5b9a\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002\u305d\u3053\u3067\u3001\u9855\u5fae\u93e1\u3092\u4f7f\u3063\u305f\u30ab\u30eb\u30b7\u30a6\u30e0\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3068\u3044\u3046\u65b9\u6cd5\u3092\u4f7f\u3044\u307e\u3059\u3002\u795e\u7d4c\u7d30\u80de\u5185\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u30a4\u30aa\u30f3\u6fc3\u5ea6\u306f\u3001\u7d30\u80de\u5916\u306b\u6bd4\u3079\u3066\u304a\u3088\u305d10\u4e07\u5206\u306e1\u4ee5\u4e0b\u306e\u6fc3\u5ea6\u3057\u304b\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u795e\u7d4c\u7d30\u80de\u304c\u6d3b\u52d5\u3059\u308b\u3068\u304d\u306b\u306f\u3001\u7d04100\u500d\u30ab\u30eb\u30b7\u30a6\u30e0\u30a4\u30aa\u30f3\u6fc3\u5ea6\u304c\u4e0a\u6607\u3057\u307e\u3059\u3002\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u30a4\u30aa\u30f3\u306b\u53cd\u5fdc\u3057\u3066\u86cd\u5149\u304c\u5f37\u304f\u306a\u308b\u30ab\u30eb\u30b7\u30a6\u30e0\u30a4\u30aa\u30f3\u30bf\u30f3\u30d1\u30af\u8cea\u30bb\u30f3\u30b5\u30fc\u3092\u7528\u3044\u308b\u3068\u3001\u795e\u7d4c\u7d30\u80de\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u30a4\u30aa\u30f3\u6fc3\u5ea6\uff08\u2252\u795e\u7d4c\u306e\u6d3b\u52d5\uff09\u3092\u6e2c\u5b9a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u30a4\u30aa\u30f3\u30bf\u30f3\u30d1\u30af\u8cea\u30bb\u30f3\u30b5\u30fc\u3092\u5168\u3066\u306e\u795e\u7d4c\u7d30\u80de\u3067\u4f5c\u3089\u305b\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u8133\u306e\u5168\u3066\u306e\u795e\u7d4c\u7d30\u80de\u306e\u500b\u5225\u306e\u6d3b\u52d5\u306e\u5909\u5316\u3092\u9855\u5fae\u93e1\u3067\u6e2c\u5b9a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002\u3053\u308c\u304c\u5168\u8133\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3067\u3059\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"544\" height=\"133\" src=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/5-4_01.jpg\" alt=\"\" class=\"wp-image-574\" srcset=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/5-4_01.jpg 544w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/5-4_01-300x73.jpg 300w\" sizes=\"(max-width: 544px) 100vw, 544px\" \/><figcaption class=\"wp-element-caption\">\u56f31\u3000\u7dda\u866b\u306e\u300c\u8133\u300d\u306e\u795e\u7d4c\u7d30\u80de<br>\u3000\u30b3\u30ed\u30f3\u30d3\u30a2\u5927\u5b66\u30db\u30d0\u30fc\u30c8\u6559\u6388\u3089\u304c\u958b\u767a\u3057\u305fNeuroPAL\u3092\u7528\u3044\u3066\u3001\u795e\u7d4c\u7d30\u80de\u6bce\u306b\u7570\u306a\u308b\u86cd\u5149\u3092\u767a\u3057\u3066\u3044\u308b\u306e\u3067\u3001\u305d\u308c\u305e\u308c\u306e\u7d30\u80de\u3092\u533a\u5225\u3067\u304d\u308b\u3002\uff08\u9752\u6728\uff65\u77f3\u539f\u3000\u672a\u767a\u8868\uff09<\/figcaption><\/figure>\n<\/div>\n\n\n<div class=\"wp-block-columns mt_30 is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:60%\">\n<h4 class=\"wp-block-heading\">\u7dda\u866b\u306e\u5168\u8133\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3063\u3066\u3069\u3046\u3084\u308b\u306e\uff1f<\/h4>\n\n\n\n<p>\u3000\u7dda\u866b\u306e\u8133\u3092\u9855\u5fae\u93e1\u3067\u89b3\u5bdf\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u9ad8\u500d\u7387\u306e\u30ec\u30f3\u30ba\u3092\u4f7f\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u9ad8\u500d\u7387\u306e\u30ec\u30f3\u30ba\u3067\u306f\u3001\u3068\u3066\u3082\u8584\u3044\u9818\u57df<span style=\"text-decoration: underline;\">\uff08\u3064\u307e\u308a\u9762\uff09<\/span>\u306b\u3057\u304b\u30d4\u30f3\u30c8\u304c\u5408\u3044\u307e\u305b\u3093\u3002\u795e\u7d4c\u7d30\u80de\u306f\u3001\u30d6\u30c9\u30a6\u306e\u623f\u306e\u3088\u3046\u306b\u30013\u6b21\u5143\u7684\u306b\u5e83\u304c\u3063\u3066\u5b58\u5728\u3057\u3066\u3044\u308b\u306e\u3067\u3001\u3072\u3068\u3064\u306e\u9762\u3060\u3051\u3092\u89b3\u5bdf\u3057\u3066\u3082\u300c\u5168\u8133\u300d\u3092\u307f\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002\u305d\u3053\u3067\u3001\u624b\u524d\u304b\u3089\u5965\u307e\u3067\u3001\u30d4\u30f3\u30c8\u304c\u5408\u3046\u4f4d\u7f6e\u3092\u5c11\u3057\u305a\u3064\u305a\u3089\u3057\u306a\u304c\u3089\u3001\u89b3\u5bdf\u3059\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u795e\u7d4c\u306e\u6d3b\u52d5\u306e\u5909\u5316\u306f\u901f\u3044\u306e\u3067\u3001\u305d\u308c\u306b\u5408\u308f\u305b\u3066\u9ad8\u901f\u306b\u89b3\u5bdf\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u306b\u3001\u9ad8\u901f\u304b\u3064\u6b63\u78ba\uff080.001\u79d2\u30670.001mm\uff09\u306b\u5bfe\u7269\u30ec\u30f3\u30ba\u3092\u52d5\u304b\u3059\u3053\u3068\u304c\u3067\u304d\u308b\u7279\u5225\u306a\u9855\u5fae\u93e1\u3092\u4f7f\u3044\u307e\u3059\uff08\u56f32\uff09\u3002<\/p>\n\n\n\n<p>\u3000\u3053\u306e\u3088\u3046\u306a\u9855\u5fae\u93e1\u3067\u306f\u30011\u79d2\u9593\u306b100\u679a\u4ee5\u4e0a\u306e\u5199\u771f\u3092\u64ae\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u7dda\u866b\u306e\u8133\u5168\u4f53\u3092\u89b3\u5bdf\u3059\u308b\u305f\u3081\u306b\u306f\u300120-30\u30f6\u6240\u306e\u30d4\u30f3\u30c8\u306e\u4f4d\u7f6e\u3067\u64ae\u5f71\u3059\u308b\u3053\u3068\u304c\u5fc5\u8981\u3067\u3059\u306e\u3067\u3001\u305d\u308c\u305e\u308c\u306e\u795e\u7d4c\u7d30\u80de\u30921\u79d2\u9593\u306b3\uff0d5\u56de\u305a\u3064\u64ae\u5f71\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u3053\u306e\u64ae\u5f71\u30925\u5206\u9593\u884c\u3063\u305f\u3068\u3059\u308b\u3068\u3001\u7dda\u866b\u306e\u795e\u7d4c\u7d30\u80de\u306e\u753b\u50cf\u306f3\u4e07\u679a\u306b\u3082\u306a\u308a\u307e\u3059\u3002<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:40%\">\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"650\" height=\"867\" src=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/5-4_02.jpg\" alt=\"\" class=\"wp-image-575\" srcset=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/5-4_02.jpg 650w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/5-4_02-225x300.jpg 225w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/><figcaption class=\"wp-element-caption\">\u56f32\u3000\u7dda\u866b\u306e\u5168\u8133\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3092\u884c\u3046\u305f\u3081\u306e\u9855\u5fae\u93e1<\/figcaption><\/figure>\n<\/div>\n<\/div>\n\n\n\n<h4 class=\"wp-block-heading\">\u7dda\u866b\u306e\u5168\u8133\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306e\u753b\u50cf\u304b\u3089\u795e\u7d4c\u6d3b\u52d5\u3092\u77e5\u308b\u306b\u306f\uff1f<\/h4>\n\n\n\n<p>\u30003\u4e07\u679a\u306b\u3082\u306a\u308b\u753b\u50cf\u304b\u3089\u305d\u308c\u305e\u308c\u306e\u795e\u7d4c\u7d30\u80de\u306e\u6d3b\u52d5\u306e\u5909\u5316\u3092\u77e5\u308b\u305f\u3081\u306b\u306f\u3001AI\u306e\u52a9\u3051\u304c\u5fc5\u8981\u3067\u3059\u3002\u307e\u305a\u3001\u7dda\u866b\u306e\u795e\u7d4c\u7d30\u80de\u3092\u3072\u3068\u3064\u3072\u3068\u3064\u898b\u5206\u3051\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u6b21\u306b\u3001\u7dda\u866b\u306f\u64ae\u5f71\u4e2d\u306b\u3082\u52d5\u304f\u306e\u3067\u3001\u52d5\u3044\u3066\u3044\u308b\u795e\u7d4c\u7d30\u80de\u3092\u8ffd\u3044\u304b\u3051\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u3046\u3048\u3067\u3001\u305d\u308c\u305e\u308c\u306e\u795e\u7d4c\u7d30\u80de\u306e\u660e\u308b\u3055\u3092\u6e2c\u5b9a\u3057\u307e\u3059\u3002\u3053\u306e\u660e\u308b\u3055\u306f\u3001\u7d30\u80de\u5185\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u30a4\u30aa\u30f3\u6fc3\u5ea6\u3092\u53cd\u6620\u3057\u3066\u3044\u308b\u306e\u3067\u3001\u305d\u308c\u305e\u308c\u306e\u795e\u7d4c\u7d30\u80de\u306e\u6d3b\u52d5\u306e\u5909\u5316\u304c\u308f\u304b\u308a\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u795e\u7d4c\u7d30\u80de\u306e\u6570\uff08\u7d04180\u500b\uff09\u306e5\u5206\u9593\u306e\u6d3b\u52d5\u5909\u5316\uff08\u6bce\u79d23\u56de\u3068\u3057\u3066\u3082900\u500b\u306e\u70b9\u306b\u306a\u308a\u307e\u3059\uff09\u306e\u30b0\u30e9\u30d5\u3092\u5f97\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\uff08\u56f33\uff09\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" width=\"1467\" height=\"470\" src=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/5-3_03.jpg\" alt=\"\" class=\"wp-image-573\" style=\"width:800px\" srcset=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/5-3_03.jpg 1467w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/5-3_03-300x96.jpg 300w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/5-3_03-1024x328.jpg 1024w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/5-3_03-768x246.jpg 768w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/5-3_03-670x215.jpg 670w\" sizes=\"(max-width: 1467px) 100vw, 1467px\" \/><figcaption class=\"wp-element-caption\">\u56f33\u3000\u7dda\u866b\u306e\u5168\u8133\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3067\u5f97\u3089\u308c\u305f\u795e\u7d4c\u6d3b\u52d5\u30c7\u30fc\u30bf\u306e\u4f8b<br>\u3000\u30d4\u30f3\u30af\u306e\u9818\u57df\u3067\u523a\u6fc0\u3092\u4e0e\u3048\u3066\u3044\u308b\u3002\u4e0a\u6bb5\u306f\u3001\u523a\u6fc0\u6642\u306b\u795e\u7d4c\u306e\u6d3b\u52d5\u304c\u4e0a\u6607\u3057\u3066\u3044\u308b\u795e\u7d4c\u7d30\u80de\u306e\u4f8b\u3002\u4e0b\u6bb5\u306f\u3001\u523a\u6fc0\u6642\u306b\u795e\u7d4c\u306e\u6d3b\u52d5\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u795e\u7d4c\u7d30\u80de\u306e\u4f8b\u3002\uff08\u6751\u4e0a\uff65\u77f3\u539f\u3000\u672a\u767a\u8868\uff09<\/figcaption><\/figure>\n<\/div>\n\n\n<div class=\"wp-block-columns mt_30 is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column sp_box_ord_01 is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:40%\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"363\" height=\"297\" src=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/5-3_04.jpg\" alt=\"\" class=\"wp-image-576\" srcset=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/5-3_04.jpg 363w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/5-3_04-300x245.jpg 300w\" sizes=\"(max-width: 363px) 100vw, 363px\" \/><figcaption class=\"wp-element-caption\">\u56f34\u3000\u795e\u7d4c\u6d3b\u52d5\u30c7\u30fc\u30bf\u3092\u30af\u30e9\u30b9\u30bf\u30ea\u30f3\u30b0\u3057\u3066\u5f97\u3089\u308c\u305f\u30d2\u30fc\u30c8\u30de\u30c3\u30d7\u753b\u50cf<br>\u7e26\u306b\u795e\u7d4c\u7d30\u80de\u304c\u4e26\u3093\u3067\u3044\u3066\u3001\u6a2a\u65b9\u5411\u306b\u6642\u9593\u7d4c\u904e\u304c\u3042\u3089\u308f\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30af\u30e9\u30b9\u30bf\u30ea\u30f3\u30b0\u3068\u3044\u3046\u624b\u6cd5\u306b\u3088\u3063\u3066\u3001\u985e\u4f3c\u306e\u6d3b\u52d5\u30d1\u30bf\u30fc\u30f3\u3092\u793a\u3059\u795e\u7d4c\u7d30\u80de\u6bce\u306b\u4e26\u3093\u3067\u3044\u307e\u3059\u3002\uff08\u6751\u4e0a\uff65\u77f3\u539f\u3000\u672a\u767a\u8868\uff09<\/figcaption><\/figure>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:60%\">\n<h4 class=\"wp-block-heading\">\u7dda\u866b\u306e\u5168\u8133\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u304b\u3089\u308f\u304b\u308b\u3053\u3068<\/h4>\n\n\n\n<p>\u3000\u3053\u3046\u3057\u3066\u5f97\u3089\u308c\u305f\u7d04180\u500b\u306e\u30b0\u30e9\u30d5\u306b\u306f\u3001\u7dda\u866b\u306e\u8133\u3067\u306e\u60c5\u5831\u51e6\u7406\u304c\u3001\u7406\u8ad6\u4e0a\u306f\u3059\u3079\u3066\u542b\u307e\u308c\u3066\u3044\u308b\u306f\u305a\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u3053\u308c\u3089\u306e\u6298\u308c\u7dda\u30b0\u30e9\u30d5\u3092\u898b\u3066\u3044\u308b\u3060\u3051\u3067\u306f\u3001\u305d\u306e\u3057\u304f\u307f\u306f\u308f\u304b\u308a\u307e\u305b\u3093\u3002\u3053\u3053\u3067\u3082AI\u306e\u52a9\u3051\u304c\u5fc5\u8981\u306b\u306a\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u540c\u3058\u3088\u3046\u306a\u6d3b\u52d5\u3092\u3057\u3066\u3044\u308b\u795e\u7d4c\u7d30\u80de\u3092\u5206\u985e\u3059\u308b\uff08\u30af\u30e9\u30b9\u30bf\u30ea\u30f3\u30b0\u3068\u547c\u3073\u307e\u3059\uff09\u3068\u304b\u795e\u7d4c\u7d30\u80de\u540c\u58eb\u306e\u60c5\u5831\u306e\u6d41\u308c\u3092\u63a8\u5b9a\u3059\u308b\u306a\u3069\u3067\u3059\u3002\u307e\u305f\u3001\u7279\u5b9a\u306e\u52d5\u304d\u3092\u3057\u3066\u3044\u308b\u3068\u304d\u306e\u795e\u7d4c\u306e\u6d3b\u52d5\u306e\u5909\u5316\u304c\u3088\u304f\u4f3c\u3066\u3044\u308b\u3053\u3068\u3082\u308f\u304b\u3063\u3066\u304d\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u308f\u304b\u308b\u3053\u3068\u306f\u307e\u3060\u307e\u3060\u305f\u304f\u3055\u3093\u3042\u308b\u306f\u305a\u3067\u3059\u3002\u7dda\u866b\u306e\u8133\u306e\u50cd\u304d\u3092\u7406\u89e3\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u30b3\u30f3\u30d4\u30e5\u30fc\u30bf\u30fc\u3092\u4f7f\u3046\u4eba\u9593\u306e\u80fd\u529b\u304c\u8ffd\u3044\u3064\u3044\u3066\u3044\u306a\u3044\u306e\u304c\u73fe\u72b6\u3067\u3059\u3002<\/p>\n<\/div>\n<\/div>\n\n\n\n<p><strong>\u53c2\u8003\u8cc7\u6599<\/strong><br>1\uff09Yemini et al.\u8457 NeuroPAL: A Multicolor Atlas for Whole-Brain Neuronal Identification in C. elegans\u30002021\u5e74\u3000Cell 184,272-288 &nbsp;doi: 10.1016\/j.cell.2020.12.012.<\/p>\n\n\n\n<p><strong>\u76e3\u4fee\u8005<\/strong><br>\u77f3\u539f \u3000\u5065<br>1963\u5e74\u6771\u4eac\u90fd\u751f\u307e\u308c\u3002\u6771\u4eac\u5927\u5b66\u5927\u5b66\u9662\u535a\u58eb\u8ab2\u7a0b\u4fee\u4e86\u3002\u535a\u58eb\uff08\u7406\u5b66\uff09\u3002\u4e5d\u5dde\u5927\u5b66\u6559\u6388\u3068\u3057\u3066\u3001\u300c\u7dda\u866b\u306b\u304a\u3051\u308b\u60c5\u5831\u51e6\u7406\u306e\u4ed5\u7d44\u307f\u300d\u3092\u7814\u7a76\u3057\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p class=\"has-text-align-right has-small-font-size\">\u00a92026 \u866b\u306e\u96c6\u3044\uff08\u7dda\u866b\u7814\u7a76\u8005\u30b3\u30df\u30e5\u30cb\u30c6\u30a3\uff09\u300c4.\u3000\u7dda\u866b\u306b\u304a\u3051\u308b\u5168\u8133\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u300d<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">CC BY<\/a><\/p>\n\n\n\n<p class=\"has-text-align-right\"><a href=\"#toc_container\">\u76ee\u6b21\u30da\u30fc\u30b8\u3078\u2191<\/a><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div><\/section>\n\n\n\n<section id=\"section-5\" class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h3 class=\"wp-block-heading\">5.\u3000\u7dda\u866b\u5b9f\u9a13\u30fb\u89e3\u6790\u306e\u305f\u3081\u306e\u30de\u30a4\u30af\u30ed\u30c1\u30c3\u30d7<\/h3>\n\n\n\n<h4 class=\"wp-block-heading has-text-align-left\">\u30de\u30a4\u30af\u30ed\u30c1\u30c3\u30d7\u3068\u306f<\/h4>\n\n\n\n<p>\u3000\u30de\u30a4\u30af\u30ed\u30d5\u30eb\u30a4\u30c7\u30a3\u30af\u30b9\uff08\u30de\u30a4\u30af\u30ed\u6d41\u4f53\u529b\u5b66\uff09\u3067\u306f\u30011\uff5e\u6570100\u30df\u30af\u30ed\u30f3\uff08\u00b5m\uff09\u306e\u5e45\u306e\u6d41\u8def\u306b\u5316\u5b66\u7269\u8cea\u3084\u751f\u4f53\u8a66\u6599\u306a\u3069\u3092\u6d41\u3057\u3001\u5316\u5b66\u53cd\u5fdc\u3084\u6db2\u4f53\u306e\u6319\u52d5\u306a\u3069\u3092\u8abf\u3079\u307e\u3059\u3002\u3053\u306e\u305f\u3081\u306e\u30c7\u30d0\u30a4\u30b9\u3068\u3057\u3066\u958b\u767a\u3055\u308c\u305f\u306e\u304c\u30de\u30a4\u30af\u30ed\uff08\u6d41\u4f53\uff09\u30c1\u30c3\u30d7\u3067\u3001\u30dd\u30ea\u30b8\u30e1\u30c1\u30eb\u30b7\u30ed\u30ad\u30b5\u30f3\uff08Polydimethylsiloxane\uff1aPDMS\uff09\u3084\u30ac\u30e9\u30b9\u3001\u6a39\u8102\u306a\u3069\u3092\u6bcd\u6750\u3068\u3057\u305f\u57fa\u677f\u306e\u4e0a\u306b\u3001\u5fae\u5c0f\u306a\u6d41\u8def\u304c\u4f5c\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p> 2000\u5e74\u4ee3\u304b\u3089\u3053\u306e\u30de\u30a4\u30af\u30ed\u30c1\u30c3\u30d7\u3092\u751f\u7269\u5b9f\u9a13\u306b\u3082\u5fdc\u7528\u3057\u3088\u3046\u3068\u3059\u308b\u8a66\u307f\u304c\u76db\u3093\u306b\u306a\u308a<sup>1)<\/sup>\u3001\u30de\u30a4\u30af\u30ed\u30c1\u30c3\u30d7\u3092\u7528\u3044\u305f\u7dda\u866b\u884c\u52d5\u8a66\u9a13\uff08\u7dda\u866b\u884c\u52d5\u30a2\u30c3\u30bb\u30a4\uff09<sup>2)<\/sup>\u3084\u751f\u4f53\u4fe1\u53f7\u8a08\u6e2c<sup>3)<\/sup>\u3001\u7dda\u866b\u7d44\u7e54\u89b3\u5bdf<sup>4)<\/sup>\u306a\u3069\u306e\u305f\u3081\u306e\u30de\u30a4\u30af\u30ed\u30c1\u30c3\u30d7\u304c\u958b\u767a\u3055\u308c\u307e\u3057\u305f\u3002\u751f\u7269\u5b9f\u9a13\u89e3\u6790\u7528\u306e\u30de\u30a4\u30af\u30ed\u30c1\u30c3\u30d7\u3068\u3057\u3066\u306f\u3001\u900f\u660e\u3067\u3042\u308b\u3053\u3068\u3084\u81ea\u5bb6\u86cd\u5149\u304c\u5c11\u306a\u3044\u3053\u3068\u3001\u9178\u7d20\u900f\u904e\u6027\u304c\u9ad8\u3044\u3053\u3068\u306a\u3069\u304c\u6c42\u3081\u3089\u308c\u308b\u305f\u3081\u3001\u3053\u308c\u3089\u306e\u6027\u8cea\u3092\u5099\u3048\u3064\u3064\u3001\u5316\u5b66\u7684\u306b\u5b89\u5b9a\u3067\u52a0\u5de5\u6027\u306b\u512a\u308c\u3066\u3044\u308b\u30b7\u30ea\u30b3\u30fc\u30f3\u6a39\u8102\u306e\u4e00\u7a2e\u3067\u3042\u308bPDMS\u3092\u6bcd\u6750\u3068\u3059\u308b\u3082\u306e\u304c\u5e83\u304f\u666e\u53ca\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading has-text-align-left\">\u884c\u52d5\u30c1\u30c3\u30d7\u3068\u55c5\u899a\u30c1\u30c3\u30d7<sup>(2)<\/sup><\/h4>\n\n\n\n<p>\u3000\u7dda\u866b\u306f\u3001\u6975\u3081\u3066\u5c0f\u3055\u3044\u305f\u3081\u3001\u523a\u6fc0\u3092\u52a0\u3048\u305f\u3068\u304d\u306e\u795e\u7d4c\u6d3b\u52d5\u3092\u8a08\u6e2c\u3059\u308b\u3053\u3068\u304c\u56f0\u96e3\u3067\u3057\u305f\u304c\u30012007\u5e74\u306b\u7dda\u866b\u306e\u795e\u7d4c\u6d3b\u52d5\u3068\u884c\u52d5\u3092\u53ef\u8996\u5316\u3059\u308b\u305f\u3081\u306e\u300c\u884c\u52d5\u30c1\u30c3\u30d7\u300d\u3068\u300c\u55c5\u899a\u30c1\u30c3\u30d7\u300d\u3068\u3044\u30462\u3064\u306e\u30de\u30a4\u30af\u30ed\u30c1\u30c3\u30d7\u304c\u958b\u767a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u884c\u52d5\u30c1\u30c3\u30d7\u306e\u4e2d\u592e\u306b\u306f\u3001\u5e45\u304c\u5f90\u3005\u306b\u72ed\u304f\u306a\u308b\u30de\u30a4\u30af\u30ed\u30c8\u30e9\u30c3\u30d7\u304c\u4f5c\u3089\u308c\u3066\u304a\u308a\u3001\u305d\u306e\u4e21\u7aef\u306b\u3001\u7dda\u866b\u306e\u5165\u53e3\u3068\u51fa\u53e3\u3068\u306a\u308b\u7a74\u304c\u305d\u308c\u305e\u308c\u8a2d\u3051\u3089\u308c\u3066\u3044\u307e\u3059\uff08\u56f31\uff09\u3002\u7dda\u866b\u306f1\u5339\u305a\u3064\u30de\u30a4\u30af\u30ed\u30c8\u30e9\u30c3\u30d7\u306b\u6295\u5165\u3055\u308c\u3001\u5165\u53e3\u3092\u52a0\u5727\u3059\u308b\u3053\u3068\u3067\u30c8\u30e9\u30c3\u30d7\u5185\u306b\u62bc\u3057\u51fa\u3055\u308c\u3001\u6700\u3082\u7d30\u3044\u5e45\u306e\u3068\u3053\u308d\u3067\u5727\u7e2e\u3055\u308c\u3066\u6b62\u307e\u308a\u307e\u3059\u3002\u982d\u90e8\u3068\u5c3e\u90e8\u306f\u3001\u539a\u307f\u304c\u30c8\u30e9\u30c3\u30d7\u3088\u308a\u3082\u5c0f\u3055\u3044\u305f\u3081\u3001\u5727\u7e2e\u3055\u308c\u305a\u3001\u81ea\u7531\u306b\u52d5\u304b\u3059\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30c8\u30e9\u30c3\u30d7\u3055\u308c\u305f\u7dda\u866b\u306f\u3001\u5bd2\u5929\u30d7\u30ec\u30fc\u30c8\u4e0a\u3092\u9019\u3046\u3068\u304d\u3068\u540c\u69d8\u306e\u6b63\u5f26\u6ce2\u3092\u767a\u751f\u3055\u305b\u3001\u982d\u90e8\u304b\u3089\u5c3e\u90e8\u3078\u3001\u5c3e\u90e8\u304b\u3089\u982d\u90e8\u3078\u3068\u6ce2\u3092\u4f1d\u3048\u3066\u3044\u304f\u305f\u3081\u3001\u3053\u306e\u6ce2\u3092\u89b3\u5bdf\u3059\u308b\u3053\u3068\u3067\u904b\u52d5\u30d1\u30bf\u30fc\u30f3\u3092\u8a55\u4fa1\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u884c\u52d5\u30c1\u30c3\u30d7\u3092\u4f7f\u3046\u3053\u3068\u3067\u3001\u60c5\u5831\u51e6\u7406\u3092\u62c5\u3046\u4ecb\u5728\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u6d3b\u52d5\u3092\u3001\u7dda\u866b\u306e\u904b\u52d5\u30d1\u30bf\u30fc\u30f3\u3068\u76f8\u95a2\u3055\u305b\u3066\u8abf\u3079\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u55c5\u899a\u30c1\u30c3\u30d7\u306f\u3001\u30de\u30a4\u30af\u30ed\u30c8\u30e9\u30c3\u30d7\u3068\u5316\u5b66\u7269\u8cea\u9001\u9054\u30b7\u30b9\u30c6\u30e0\u3068\u3092\u5099\u3048\u3066\u3044\u307e\u3059\uff08\u56f32\uff09\u3002\u7dda\u866b\u304c\u30de\u30a4\u30af\u30ed\u30c8\u30e9\u30c3\u30d7\u306b\u30bb\u30c3\u30c8\u3055\u308c\u308b\u3068\u3001\u9f3b\u306e\u5148\u7aef\u304c\u30c8\u30e9\u30c3\u30d7\u3092\u6d41\u308c\u308b\u6eb6\u6db2\u306e\u4e2d\u306b\u7a81\u304d\u51fa\u308b\u305f\u3081\u3001\u9f3b\u306e\u5148\u7aef\u306b\u3042\u308b\u5316\u5b66\u53d7\u5bb9\u4f53\u7e4a\u6bdb\u306f\u5e38\u306b\u6c34\u6d41\u306b\u3055\u3089\u3055\u308c\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u55c5\u899a\u30c1\u30c3\u30d7\u306e\u5316\u5b66\u7269\u8cea\u9001\u9054\u30b7\u30b9\u30c6\u30e0\u306f\u3001\u523a\u6fc0\u6eb6\u6db2\uff08\u30c1\u30e3\u30cd\u30ebA\uff09\u3068\u5bfe\u8c61\u3068\u306a\u308b\u6a19\u6e96\u306e\u6eb6\u6db2\uff08\u30c1\u30e3\u30cd\u30ebB\uff09\u3092\u7dda\u866b\u306e\u9f3b\u306b\u9001\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u6a5f\u68b0\u7684\u3001\u6d78\u900f\u5727\u7684\u3001\u5316\u5b66\u7684\u523a\u6fc0\u306b\u53cd\u5fdc\u3059\u308b\u611f\u899a\u30cb\u30e5\u30fc\u30ed\u30f3\u3067\u3042\u308bASH\u30cb\u30e5\u30fc\u30ed\u30f3\u306bG-CaMP\u304c\u767a\u73fe\u3059\u308b\u3088\u3046\u306b\u3057\u305f\u4e0a\u3067\u3001\u55c5\u899a\u30c1\u30c3\u30d7\u3092\u4f7f\u3063\u3066\u9ad8\u6d78\u900f\u5727\u523a\u6fc0\u306b\u3055\u3089\u3055\u308c\u305f\u3068\u304d\u306eASH\u30cb\u30e5\u30fc\u30ed\u30f3\u5185\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u53cd\u5fdc\u3092\u8abf\u3079\u305f\u5b9f\u9a13\u3067\u306f\u3001\u7d99\u7d9a\u7684\u306a\u53cd\u5fdc\u304c\u8a8d\u3081\u3089\u308c\u3001\u9ad8\u6d78\u900f\u5727\u6eb6\u6db2\u306e\u9664\u53bb\u306b\u5bfe\u3057\u3066\u3082\u30ab\u30eb\u30b7\u30a6\u30e0\u30ec\u30d9\u30eb\u306e\u4e00\u6642\u7684\u306a\u4e0a\u6607\u3067\u53cd\u5fdc\u3059\u308b\u3053\u3068\u306a\u3069\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>2\u3064\u306e\u30de\u30a4\u30af\u30ed\u30c1\u30c3\u30d7\u3092\u4f7f\u3063\u305f\u795e\u7d4c\u53cd\u5fdc\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u3092\u901a\u3057\u3066\u3001\u3053\u308c\u307e\u3067\u77e5\u3089\u308c\u3066\u3044\u306a\u304b\u3063\u305f\u30cb\u30e5\u30fc\u30ed\u30f3\u7279\u6027\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3053\u306e\u7814\u7a76\u304c\u3072\u3068\u3064\u306e\u304d\u3063\u304b\u3051\u3068\u306a\u308a\u3001\u7dda\u866b\u5b9f\u9a13\u30fb\u89e3\u6790\u7528\u30de\u30a4\u30af\u30ed\u30c1\u30c3\u30d7\u306e\u958b\u767a\u304c\u52a0\u901f\u3057\u3001\u8907\u96d1\u5316\u3001\u9ad8\u7cbe\u5ea6\u5316\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading has-text-align-left\">\u30a8\u30ec\u30af\u30c8\u30ed\u30d5\u30a1\u30ea\u30f3\u30b8\u30aa\u30b0\u30e9\u30e0\u8a08\u6e2c\u7528\u30de\u30a4\u30af\u30ed\u30c1\u30c3\u30d7<sup>(3)<\/sup><\/h4>\n\n\n\n<p>\u3000\u7dda\u866b\u306e\u795e\u7d4c\u7b4b\u6a5f\u80fd\u3092\u975e\u4fb5\u8972\u7684\u306b\u6e2c\u5b9a\u3059\u308b\u6a5f\u80fd\u3092\u6301\u305f\u305b\u305f\u30de\u30a4\u30af\u30ed\u30c1\u30c3\u30d7\u304c\u958b\u767a\u3055\u308c<sup>3)<\/sup>\u3001\u85ac\u5264\u306e\u751f\u4f53\u5f71\u97ff\u306a\u3069\u3092\u8abf\u3079\u308b\u5316\u5b66\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306b\u5fdc\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u30de\u30a4\u30af\u30ed\u30c1\u30c3\u30d7\u306f\u3001\u96fb\u6975\u3092\u53d6\u308a\u4ed8\u3051\u305f\u5fae\u5c0f\u6d41\u8def\u3067\u69cb\u6210\u3055\u308c\u3066\u304a\u308a\u3001\u7dda\u866b\u306e\u5480\u3057\u3083\u304f\u3068\u56a5\u4e0b\u3092\u62c5\u3046\u54bd\u982d\u306e\u7b4b\u8089\u304a\u3088\u3073\u795e\u7d4c\u7d30\u80de\u304b\u3089\u30dd\u30f3\u30d4\u30f3\u30b0\u904b\u52d5\uff08\u6442\u98df\uff09\u4e2d\u306b\u653e\u51fa\u3055\u308c\u308b\u96fb\u6c17\u4fe1\u53f7\u3067\u3042\u308b\u30a8\u30ec\u30af\u30c8\u30ed\u30d5\u30a1\u30ea\u30f3\u30b8\u30aa\u30b0\u30e9\u30e0\uff08Electropharyngeograms\uff1aEPGs\uff09\u3092\u8a18\u9332\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306eEPG\u8a18\u9332\u7528\u7528\u30de\u30a4\u30af\u30ed\u30c1\u30c3\u30d7\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u3001\u65e2\u77e5\u306e\u6297\u7dda\u866b\u85ac\uff08\u5316\u5b66\u8fb2\u85ac\uff09\u306e\u6025\u6027\u52b9\u679c\u3092\u691c\u51fa\u3057\u305f\u308a\u3001\u7279\u5b9a\u306e\u85ac\u5264\u8010\u6027\u7a81\u7136\u5909\u7570\u682a\u3092\u91ce\u751f\u578b\u3068\u8b58\u5225\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u690d\u7269\u5bc4\u751f\u6027\u7dda\u866b\u306e\u9632\u9664\u7814\u7a76\u3084\u5404\u7a2e\u75be\u75c5\u306b\u5bfe\u3059\u308b\u5275\u85ac\u7814\u7a76\u3078\u306e\u3055\u3089\u306a\u308b\u5fdc\u7528\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading has-text-align-left\">\u7dda\u866b\u4fdd\u5b9a\u7528\u30de\u30a4\u30af\u30ed\u30c1\u30c3\u30d7<sup>(4)<\/sup><\/h4>\n\n\n\n<p>\u3000\u9ebb\u9154\u85ac\u3092\u4f7f\u308f\u305a\u306b\u7dda\u866b\u306e\u52d5\u304d\u3092\u6291\u3048\u308b\u4fdd\u5b9a\u5c02\u7528\u306e\u30de\u30a4\u30af\u30ed\u30c1\u30c3\u30d7\u304c\u958b\u767a\u3055\u308c<sup>4)<\/sup>\u3001\u899a\u9192\u72b6\u614b\u306e\u7dda\u866b\u306e\u7d44\u7e54\u306e\u89b3\u5bdf\u3084\u7279\u5b9a\u306e\u7d44\u7e54\u3092\u72d9\u3063\u305f\u91cf\u5b50\u30d3\u30fc\u30e0\u7167\u5c04\u306a\u3069\u306b\u6d3b\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7dda\u866b\u4fdd\u5b9a\u7528\u30de\u30a4\u30af\u30ed\u30c1\u30c3\u30d7\u306b\u306f\u3001\u7dda\u866b\uff08<em>C. elegans<\/em>\uff09\u306e\u6210\u866b\u306e\u4f53\u306e\u5e45\u306b\u76f8\u5f53\u3059\u308b50 \u00b5m\u307e\u305f\u306f60 \u00b5m\u306e\u76f4\u7dda\u72b6\u306e\u30de\u30a4\u30af\u30ed\u30c1\u30e3\u30cd\u30eb\uff08\u6e9d\uff09\u304c\u4f5c\u3089\u308c\u3066\u304a\u308a\u3001\u30c1\u30e3\u30cd\u30eb\u306b\u7dda\u866b\u3092\u53ce\u5bb9\u3059\u308b\u3053\u3068\u3067\u3001\u9ebb\u9154\u85ac\u3092\u4f7f\u308f\u305a\u306b\u826f\u597d\u306a\u72b6\u614b\u3067\u52d5\u304d\u3092\u6291\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\uff08\u52d5\u753b1\uff09\u3002<\/p>\n\n\n\n<p>\u52d5\u753b1: \u7dda\u866b\u3092Worm Sheet\u306b\u53ce\u5bb9\u4fdd\u5b9a\u3059\u308b\u65b9\u6cd5\u306e\u7d39\u4ecb\u52d5\u753b <\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"\u7dda\u866b\u3092Worm Sheet\u306b\u53ce\u5bb9\u4fdd\u5b9a\u3059\u308b\u65b9\u6cd5\u306e\u7d39\u4ecb\u52d5\u753b\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/Ht-TwxzL2rc?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<p><strong>\u53c2\u8003\u8cc7\u6599<\/strong><br>1\uff09Xiaojuan Zhang, Jiadi Sun, Xiao Yuan, Xin Lu, Xiulan Sun, Advances in <em>C. elegans<\/em> behavior research with microfluidic devices and its future prospects in the evaluation of exogenous pollutants. TrAC Trends in Analytical Chemistry, 136, 116195 (2021).<\/p>\n\n\n\n<p>2\uff09Nikos Chronis, Manuel Zimmer, Cornelia I Bargmann, Microfluidics for in vivo imaging of neuronal and behavioral activity in <em>Caenorhabditis elegans<\/em>. Nature Methods volume 4, pages727\u2013731 (2007). https:\/\/www.nature.com\/articles\/nmeth1075<\/p>\n\n\n\n<p>3\uff09Janis C. Weeks, Kristin J. Robinson, Shawn R. Lockery, William M. Roberts, Anthelmintic drug actions in resistant and susceptible <em>C. elegans<\/em> revealed by electrophysiological recordings in a multichannel microfluidic device. International Journal for Parasitology: Drugs and Drug Resistance, 8(3), 607-628 (2018). DOI\uff1ahttps:\/\/doi.org\/10.1016\/j.ijpddr.2018.10.003<\/p>\n\n\n\n<p>4\uff09Michiyo Suzuki, Tetsuya Sakashita, Yuya Hattori, Yuichiro Yokota, Yasuhiko Kobayashi, Tomoo Funayama, Development of ultra-thin chips for immobilization of <em>Caenorhabditis elegans<\/em> in microfluidic channels during irradiation and selection of buffer solution to prevent dehydration. Journal of Neuroscience Methods, 306: 32-37 (2018). DOI: 10.1016\/j.jneumeth.2018.05.025<\/p>\n\n\n\n<p><strong>\u76e3\u4fee\u8005<\/strong><br>\u9234\u6728\u3000\u82b3\u4ee3\u3000<br>\u9759\u5ca1\u770c\u751f\u307e\u308c\u3001\u5e83\u5cf6\u5927\u5b66\u5b66\u6821\u6559\u80b2\u5b66\u90e8\u5352\u696d\u3001\u540c\u5927\u5b66\u9662\u5de5\u5b66\u7814\u7a76\u79d1\u535a\u58eb\u8ab2\u7a0b\u5f8c\u671f\u4fee\u4e86\u3001QST\u91cf\u5b50\u30d0\u30a4\u30aa\u6280\u8853\u5fdc\u7528\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u30ea\u30fc\u30c0\u30fc\uff0f\u4e0a\u5e2d\u7814\u7a76\u54e1\u3002\u7dda\u866b\u306e\u8d85\u9ad8\u5ea6\u306a\u653e\u5c04\u7dda\u8010\u6027\u3084\u55c5\u899a\u306a\u3069\u306e\u512a\u308c\u305f\u6a5f\u80fd\u306e\u7814\u7a76\u3068\u5b9f\u9a13\u65b9\u6cd5\u306e\u6539\u826f\u30fb\u958b\u767a\u3001\u690d\u7269\u5bc4\u751f\u6027\u7dda\u866b\u306e\u9632\u9664\u6280\u8853\u306e\u958b\u767a\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u308b\u3002<\/p>\n\n\n\n<p class=\"has-text-align-right has-small-font-size\">\u00a92026 \u866b\u306e\u96c6\u3044\uff08\u7dda\u866b\u7814\u7a76\u8005\u30b3\u30df\u30e5\u30cb\u30c6\u30a3\uff09\u300c5.\u3000\u7dda\u866b\u5b9f\u9a13\u30fb\u89e3\u6790\u306e\u305f\u3081\u306e\u30de\u30a4\u30af\u30ed\u30c1\u30c3\u30d7\u300d<a href=\"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\">CC BY NC<\/a><\/p>\n\n\n\n<p class=\"has-text-align-right\"><a href=\"#toc_container\">\u76ee\u6b21\u30da\u30fc\u30b8\u3078\u2191<\/a><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div><\/section>\n","protected":false},"excerpt":{"rendered":"<p>\u76ee\u6b21 Illustrated by Hiroko Uchida \u3000\u7dda\u866b\u3092\u5bfe\u8c61\u3068\u3057\u305f\u751f\u547d\u79d1\u5b66\u7814\u7a76\u306e\u9032\u5c55 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":666,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-677","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-json\/wp\/v2\/pages\/677","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-json\/wp\/v2\/comments?post=677"}],"version-history":[{"count":12,"href":"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-json\/wp\/v2\/pages\/677\/revisions"}],"predecessor-version":[{"id":1335,"href":"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-json\/wp\/v2\/pages\/677\/revisions\/1335"}],"up":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-json\/wp\/v2\/pages\/666"}],"wp:attachment":[{"href":"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-json\/wp\/v2\/media?parent=677"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}