{"id":676,"date":"2025-02-03T11:20:14","date_gmt":"2025-02-03T02:20:14","guid":{"rendered":"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/?page_id=676"},"modified":"2026-02-12T17:59:22","modified_gmt":"2026-02-12T08:59:22","slug":"about-4","status":"publish","type":"page","link":"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/about\/about-4\/","title":{"rendered":"\u7dda\u866b\u3082\u5e74\u8001\u3044\u305f\u308a\u75c5\u6c17\u306b\u306a\u3063\u305f\u308a\u3059\u308b\u306e\uff1f"},"content":{"rendered":"\n<div id=\"toc_container\" class=\"wp-block-group pada_30\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h2 class=\"wp-block-heading\">\u76ee\u6b21<\/h2>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<ul class=\"wp-block-list\">\n<li class=\"has-medium-font-size\"><strong><a href=\"#section-1\" data-type=\"internal\" data-id=\"#section-1\">\u7dda\u866b\u304b\u3089\u898b\u308b\u6297\u8001\u5316\u7814\u7a76\u306e\u6b74\u53f2<\/a><\/strong><\/li>\n\n\n\n<li class=\"has-medium-font-size\"><strong><a href=\"#section-2\">\u7dda\u866b\u3092\u7528\u3044\u305f\u5bff\u547d\u6e2c\u5b9a\u3068\u6297\u8001\u5316\u7814\u7a76<\/a><\/strong><\/li>\n\n\n\n<li class=\"has-medium-font-size\"><strong><a href=\"#section-3\">\u8001\u5316\u3067\u8d77\u3053\u308b\u4f53\u306e\u5909\u5316<\/a><\/strong><\/li>\n\n\n\n<li class=\"has-medium-font-size\"><strong><a href=\"#section-4\">\u795e\u7d4c\u30fb\u884c\u52d5\u306e\u8001\u5316<\/a><\/strong><\/li>\n\n\n\n<li class=\"has-medium-font-size\"><strong><a href=\"#section-5\">\u7dda\u866b\u3067\u795e\u7d4c\u306e\u75c5\u6c17\u3092\u8abf\u3079\u308b<\/a><\/strong><\/li>\n\n\n\n<li class=\"has-medium-font-size\"><strong><a href=\"#section-6\">\u5207\u65ad\u3055\u308c\u305f\u795e\u7d4c\u304c\u518d\u751f\u3059\u308b\u4ed5\u7d44\u307f\u3092\u7dda\u866b\u3067\u63a2\u308b<\/a><\/strong><\/li>\n\n\n\n<li class=\"has-medium-font-size\"><a href=\"#section-7\"><strong>\u611f\u67d3\u30e2\u30c7\u30eb\u3068\u3057\u3066\u306e\u7dda\u866b<\/strong><\/a><\/li>\n<\/ul>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"1024\" height=\"766\" src=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/06\/50ee45378dd76edb6c59d20243e1b962.png\" alt=\"\" class=\"wp-image-1061\" srcset=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/06\/50ee45378dd76edb6c59d20243e1b962.png 1024w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/06\/50ee45378dd76edb6c59d20243e1b962-300x224.png 300w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/06\/50ee45378dd76edb6c59d20243e1b962-768x575.png 768w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/06\/50ee45378dd76edb6c59d20243e1b962-670x501.png 670w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"has-text-align-right has-small-font-size\">Illustrated by Hiroko Uchida&nbsp;<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group\" style=\"font-size:1.2em\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<p>\u7dda\u866b\u306f\u3001\u8001\u5316\u3001\u75be\u60a3\u3001\u640d\u50b7\u3084\u611f\u67d3\u75c7\u306a\u3069\u306e\u3088\u3046\u306a\u3001\u79c1\u305f\u3061\u306e\u5065\u5eb7\u3092\u304a\u3073\u3084\u304b\u3059\u3055\u307e\u3056\u307e\u306a\u73fe\u8c61\u306b\u3064\u3044\u3066\u3082\u591a\u304f\u306e\u793a\u5506\u3092\u4e0e\u3048\u3066\u304f\u308c\u307e\u3059\u3002\u672c\u9805\u76ee\u3067\u306f\u3001\u7dda\u866b\u306e\u6297\u8001\u5316\u7814\u7a76\u306e\u6b74\u53f2\u3092\u6982\u8aac\u3057\u305f\u306e\u3061\uff08\uff14\uff0d\uff11\uff09\u3001\u8001\u5316\u7814\u7a76\u306e\u305f\u3081\u306b\u500b\u4f53\u306e\u5bff\u547d\u3092\u6e2c\u308b\u65b9\u6cd5\u3084\u6700\u65b0\u306e\u6297\u8001\u5316\u7814\u7a76\uff08\uff14\uff0d\uff12\uff09\u3001\u8001\u5316\u306b\u4f34\u3063\u3066\u751f\u3058\u308b\u304b\u3089\u3060\u306e\u5909\u5316\uff08\uff14\uff0d\uff13\uff09\u3068\u884c\u52d5\u30fb\u795e\u7d4c\u7d30\u80de\u306e\u5909\u5316\uff08\uff14\uff0d\uff14\uff09\u306b\u3064\u3044\u3066\u8aac\u660e\u3057\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u7dda\u866b\u3092\u75be\u60a3\u3001\u640d\u50b7\u3084\u611f\u67d3\u75c7\u306e\u30e2\u30c7\u30eb\u3068\u3057\u3066\u5229\u7528\u3059\u308b\u8a66\u307f\u3068\u3057\u3066\u3001\u795e\u7d4c\u5909\u6027\u75be\u60a3\u30e2\u30c7\u30eb\uff08\uff14\uff0d\uff15\uff09\u3001\u8ef8\u7d22\u640d\u50b7\u30e2\u30c7\u30eb\uff08\uff14\uff0d\uff16\uff09\u3001\u611f\u67d3\u75c7\u30e2\u30c7\u30eb\uff08\uff14\uff0d\uff17\uff09\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u76e3\u4fee\u8005<\/strong><br>\u91ce\u9593\u3000\u5065\u592a\u90ce\u3000<br>1982\u5e74\u9999\u5ddd\u770c\u751f\u307e\u308c\u3002\u4eac\u90fd\u5927\u5b66 \u5927\u5b66\u9662\u535a\u58eb\u8ab2\u7a0b\u4fee\u4e86\u3002\u73fe\u5728\u3001\u540d\u53e4\u5c4b\u5927\u5b66\u51c6\u6559\u6388\u3068\u3057\u3066\u3001\u884c\u52d5\u8001\u5316\u306e\u907a\u4f1d\u7684\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p class=\"has-text-align-right has-small-font-size\">\u00a92026 \u866b\u306e\u96c6\u3044\uff08\u7dda\u866b\u7814\u7a76\u8005\u30b3\u30df\u30e5\u30cb\u30c6\u30a3\uff09\u300c\u5e8f\u8ad6\u300d<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">CC BY<\/a><\/p>\n\n\n\n<p class=\"has-text-align-right\"><\/p>\n<\/div><\/div>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<section id=\"section-1\" class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h3 class=\"wp-block-heading\">1.\u3000\u7dda\u866b\u304b\u3089\u898b\u308b\u6297\u8001\u5316\u7814\u7a76\u306e\u6b74\u53f2<\/h3>\n\n\n\n<h4 class=\"wp-block-heading has-text-align-left\">\u6297\u8001\u5316\u7814\u7a76\u306e\u840c\u82bd<\/h4>\n\n\n\n<p>\u4eba\u985e\u306f\u5927\u6614\u304b\u3089\u8001\u5316\u306b\u6297\u3046\u65b9\u6cd5\u3092\u6a21\u7d22\u3057\u7d9a\u3051\u3066\u304d\u305f\u6b74\u53f2\u304c\u3042\u308b\u3002\u53e4\u4ee3\u30e1\u30bd\u30dd\u30bf\u30df\u30a2\u306e\u30ae\u30eb\u30ac\u30e1\u30b7\u30e5\u53d9\u4e8b\u8a69\u306b\u306f\u4e0d\u8001\u4e0d\u6b7b\u306b\u95a2\u3059\u308b\u8a18\u8ff0\u304c\u3042\u308a\u3001\u6771\u6d0b\u3067\u306f\u59cb\u7687\u5e1d\u304c\u4e0d\u8001\u9577\u5bff\u306e\u85ac\u3092\u63a2\u3057\u6c42\u3081\u305f\u5f90\u798f\u4f1d\u8aac\u306a\u3069\u304c\u6709\u540d\u3067\u3042\u308b\u3002\u3057\u304b\u3057\u3053\u308c\u3089\u306f\u4f1d\u627f\u30fb\u4f1d\u8aac\u3067\u3057\u304b\u306a\u304f\u3001\u73fe\u4ee3\u307e\u3067\u7d9a\u304f\u79d1\u5b66\u7684\u306a\u6297\u8001\u5316\u7814\u7a76\u306e\u8d77\u70b9\u306f\u5341\u516d\u4e16\u7d00\u306e\u30eb\u30a4\u30fc\u30b8\u30fb\u30b3\u30eb\u30ca\u30fc\u30ed\u306e\u8457\u66f8&#8221;The art of living long&#8221;\u306e\u300e\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u304c\u9577\u5bff\u306b\u6709\u7528\u3067\u3042\u308b\u300f\u3068\u3044\u3046\u8a18\u8ff0\u306b\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u3002\u305d\u3057\u30661930\u5e74\u4ee3\u306b\u306f\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u3067\u30de\u30a6\u30b9\u3084\u30e9\u30c3\u30c8\u306e\u5bff\u547d\u304c\u5ef6\u3070\u305b\u308b\u4e8b\u304c\u5b9f\u9a13\u7684\u306b\u5b9f\u8a3c\u3055\u308c\u3001\u3053\u306e\u767a\u898b\u304c\u73fe\u4ee3\u7684\u306a\u6297\u8001\u5316\u7814\u7a76\u306e\u840c\u82bd\u3060\u3068\u3044\u3048\u308b\u3060\u308d\u3046\u3002\u4e00\u65b9\u3001\u3053\u306e\u767a\u898b\u306f\u300e\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u304c\u3069\u306e\u3088\u3046\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u3067\u5bff\u547d\u3092\u5236\u5fa1\u3059\u308b\u306e\u304b\u300f\u3068\u3044\u3046\u65b0\u3057\u3044\u8b0e\u3092\u751f\u307f\u3060\u3059\u4e8b\u3068\u306a\u3063\u305f\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading has-text-align-left\">\u5bff\u547d\u5236\u5fa1\u907a\u4f1d\u5b50\u306e\u767a\u898b<\/h4>\n\n\n\n<p>\u4e8c\u5341\u4e16\u7d00\u524d\u534a\u5f53\u6642\u3001\u5bff\u547d\u3092\u5236\u5fa1\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u5019\u88dc\u3068\u907a\u4f1d\u5b50\u304c\u8003\u3048\u3089\u308c\u3066\u3044\u305f\u304c\u3001\u3053\u306e\u30a2\u30a4\u30c7\u30a2\u306f\u8cdb\u5426\u6e26\u5dfb\u304f\u3082\u306e\u3067\u3042\u3063\u305f\u305f\u3081\u306b\u7814\u7a76\u8005\u305f\u3061\u306f\u300e\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u5bff\u547d\u304c\u6c7a\u307e\u308b\u306e\u304b\u3001\u907a\u4f1d\u5b50\u306e\u50cd\u304d\u3067\u5bff\u547d\u304c\u5ef6\u3070\u305b\u308b\u306e\u304b\u300f\u3068\u3044\u3046\u554f\u3044\u306b\u6311\u3080\u4e8b\u3068\u306a\u3063\u305f\u3002\u3053\u306e\u6311\u6226\u3067\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u305f\u751f\u7269\u304c\u7dda\u866b\uff08<em>C. elegans<\/em>\uff09\u3067\u3042\u308b\u3002\u7dda\u866b\u306f\u96cc\u96c4\u540c\u4f53\u306a\u306e\u3067\u89aa\u3068\u5b50\u4f9b\u304c\u907a\u4f1d\u7684\u30af\u30ed\u30fc\u30f3\u306e\u95a2\u4fc2\u306b\u3042\u308a\u3001\u7523\u5375\u6570\u304c\u591a\u304f\u3001\u500b\u4f53\u30b5\u30a4\u30ba\u3082\u5c0f\u3055\u3044\u305f\u3081\u306b\u907a\u4f1d\u5b50\u306e\u5f71\u97ff\u3092\u591a\u6570\u306e\u500b\u4f53\u3092\u7528\u3044\u3066\u540c\u6642\u306b\u8abf\u3079\u3084\u3059\u3044\u3068\u3044\u3046\u5229\u70b9\u304c\u3042\u308b\u3002\u307e\u305f\u7814\u7a76\u5ba4\u74b0\u5883\u3067\u306e\u7dda\u866b\u306e\u5bff\u547d\u306f\u6700\u5927\u3067\u4e00\u304b\u6708\u7a0b\u5ea6\u3068\u6bd4\u8f03\u7684\u5bff\u547d\u304c\u77ed\u3044\u4e8b\u3082\u7814\u7a76\u306b\u6709\u5229\u306a\u70b9\u3067\u3042\u308b\u3002\u305d\u3057\u30661983\u5e74\u306b\u30de\u30a4\u30b1\u30eb\u30fb\u30af\u30e9\u30fc\u30b9\u3089\u306b\u3088\u3063\u3066\u7dda\u866b\u306b\u907a\u4f1d\u5b50\u5909\u7570\u3092\u8a98\u5c0e\u3059\u308b\u4e8b\u3067\u9577\u5bff\u5909\u7570\u682a\u304c\u5f97\u3089\u308c\u308b\u4e8b\u304c\u5831\u544a\u3055\u308c\u3001\u3059\u306a\u308f\u3061\u907a\u4f1d\u5b50\u306e\u50cd\u304d\u3067\u5bff\u547d\u304c\u5ef6\u3070\u305b\u308b\u4e8b\u304c\u5b9f\u8a3c\u3055\u308c\u305f\u3002\u7d9a\u304f1988\u5e74\u306b\u306f\u30c7\u30a4\u30d3\u30c3\u30c9\u30fb\u30d5\u30ea\u30fc\u30c9\u30de\u30f3\u3089\u306b\u3088\u3063\u3066\u30af\u30e9\u30fc\u30b9\u3089\u304c\u5358\u96e2\u3057\u305f\u9577\u5bff\u5909\u7570\u682a\u306e\u89e3\u6790\u306b\u3088\u308a\u4e16\u754c\u3067\u521d\u3081\u3066\u5bff\u547d\u5ef6\u9577\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u3068\u3057\u3066<em>age-1<\/em>\u907a\u4f1d\u5b50\uff08\u7dda\u866bPI3K\u30db\u30e2\u30ed\u30b0\uff09\u304c\u540c\u5b9a\u3055\u308c\u305f\u3002\u3053\u306e\u69d8\u306b\u300e\u5bff\u547d\uff0f\u8001\u5316\u3092\u5236\u5fa1\u3059\u308b\u907a\u4f1d\u5b50\u300f\u3068\u3044\u3046\u5b9f\u614b\u306e\u767a\u898b\u306b\u3088\u308a\u3001\u6297\u8001\u5316\u7814\u7a76\u306f\u65b0\u3057\u3044\u30d1\u30e9\u30c0\u30a4\u30e0\u306b\u5165\u3063\u305f\u3002\u305d\u3057\u3066\u3001\u7814\u7a76\u8005\u305f\u3061\u306f\u3055\u3089\u306a\u308b\u5bff\u547d\u5236\u5fa1\u907a\u4f1d\u5b50\u306e\u63a2\u7d22\u306b\u8235\u3092\u5207\u308b\u4e8b\u3068\u306a\u3063\u305f\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading has-text-align-left\">\u5bff\u547d\u5236\u5fa1\u907a\u4f1d\u5b50\u306e\u63a2\u7d22<\/h4>\n\n\n\n<p>\u5bff\u547d\u7814\u7a76\u306b\u304a\u3044\u3066<em>age-1<\/em>\u907a\u4f1d\u5b50\u306e\u6b21\u306b\u5927\u304d\u306a\u8ee2\u63db\u70b9\u3068\u306a\u3063\u305f\u306e\u306f\u30011993\u5e74\u306e\u30b7\u30f3\u30b7\u30a2\u30fb\u30b1\u30cb\u30aa\u30f3\u3089\u306e<em>daf-2<\/em>\u907a\u4f1d\u5b50\u5909\u7570\u306b\u3088\u308b\u5bff\u547d\u5ef6\u9577\u306e\u767a\u898b\u3067\u3042\u3063\u305f\u3002<em>daf-2<\/em>\u907a\u4f1d\u5b50\u306f\u3082\u3068\u3082\u3068\u8010\u6027\u5e7c\u866b(dauer)\u3068\u3088\u3070\u308c\u308b\u7dda\u866b\u306e\u4f11\u7720\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u3068\u3057\u3066\u767a\u898b\u3055\u308c\u3066\u304a\u308a(daf: abnormal dauer formation)\u3001\u3053\u306e\u767a\u898b\u306f\u4f11\u7720\u3068\u5bff\u547d\u306b\u5171\u901a\u306e\u5236\u5fa1\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u5b58\u5728\u3059\u308b\u4e8b\u3092\u610f\u5473\u3059\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u4f11\u7720\u3068\u3044\u3046\u5bff\u547d\u3088\u308a\u77ed\u671f\u9593\u3067\u89b3\u5bdf\u53ef\u80fd\u306a\u8868\u73fe\u578b\u3092\u5229\u7528\u3059\u308c\u3070\u3088\u308a\u52b9\u7387\u7684\u306b\u5bff\u547d\u5236\u5fa1\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u8abf\u3079\u3089\u308c\u308b\u3068\u3044\u3046\u53ef\u80fd\u6027\u3092\u793a\u3059\u3082\u306e\u3067\u3042\u3063\u305f\u3002\u305d\u3057\u30661995\u5e74\u306b\u306f\u30d1\u30e1\u30e9\u30fb\u30e9\u30fc\u30bb\u30f3\u3089\u306b\u3088\u3063\u3066\u8010\u6027\u5e7c\u866b\u3092\u6307\u6a19\u306b\u3059\u308b\u4e8b\u3067\u5bff\u547d\u5236\u5fa1\u907a\u4f1d\u5b50\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u660e\u3089\u304b\u306b\u51fa\u6765\u308b\u4e8b\u304c\u5831\u544a\u3055\u308c\u305f\u3002\u307e\u305f\u3001\u3053\u306e\u9803\u3068\u524d\u5f8c\u3057\u3066\u30b2\u30ce\u30e0\u89e3\u6790\u306a\u3069\u306e\u907a\u4f1d\u5b66\u7684\u624b\u6cd5\u304c\u98db\u8e8d\u7684\u306b\u767a\u5c55\u3059\u308b\u4e8b\u30671997\u5e74\u306b\u306f\u6728\u6751\u5e78\u592a\u90ce\u3089\u306b\u3088\u3063\u3066<em>daf-2<\/em>\u907a\u4f1d\u5b50\u304c\u30d2\u30c8\u307e\u3067\u9032\u5316\u7684\u306b\u4fdd\u5b58\u3055\u308c\u305f\u30a4\u30f3\u30b9\u30ea\u30f3\u53d7\u5bb9\u4f53\u3067\u3042\u308b\u4e8b\u304c\u660e\u3089\u304b\u306b\u3055\u308c\u30012001\u5e74\u306b\u306f\u30bf\u30bf\u30fc\u30eb\u30fb\u30b3\u30da\u30eb\u30de\u30f3\u3084\u30c7\u30d3\u30c3\u30c9\u30fb\u30af\u30e9\u30f3\u30b7\u30fc\u3089\u306b\u3088\u3063\u3066\u30b7\u30e7\u30a6\u30b8\u30e7\u30a6\u30d0\u30a8\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u30b7\u30b0\u30ca\u30eb\u304c\u30012003\u5e74\u306b\u306f\u30de\u30eb\u30c6\u30a3\u30f3\u30fb\u30db\u30eb\u30c4\u30a7\u30f3\u30d9\u30eb\u30ac\u30fc\u3089\u306b\u3088\u3063\u3066\u30de\u30a6\u30b9\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u69d8\u53d7\u5bb9\u4f53\u304c\u5bff\u547d\u5ef6\u9577\u306b\u95a2\u308f\u3063\u3066\u3044\u308b\u4e8b\u304c\u660e\u3089\u304b\u306b\u3055\u308c\u308b\u306a\u3069\u3001\u7dda\u866b\u3067\u767a\u898b\u3055\u308c\u305f\u5bff\u547d\u5236\u5fa1\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u7dda\u866b\u304b\u3089\u54fa\u4e73\u985e\u307e\u3067\u9032\u5316\u7684\u306b\u4fdd\u5b58\u3055\u308c\u3066\u3044\u308b\u4e8b\u304c\u660e\u3089\u304b\u306b\u3055\u308c\u305f\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u767a\u898b\u306b\u3088\u3063\u3066\u6297\u8001\u5316\u7814\u7a76\u306b\u304a\u3051\u308b\u7dda\u866b\u306e\u6709\u7528\u6027\u304c\u5e83\u304f\u77e5\u308c\u6e21\u3063\u305f\u7d50\u679c\u3001\u7dda\u866b\u3092\u7528\u3044\u305f\u6297\u8001\u5316\u7814\u7a76\u306b\u95a2\u3059\u308b\u8ad6\u6587\u306f2000\u5e74\u306b\u5e74\u9593\u7d0450\u5831\u7a0b\u5ea6\u3060\u3063\u305f\u3082\u306e\u304c\u30012020\u5e74\u306b\u306f\u5e74\u9593400\u5831\u3092\u8d85\u3048\u308b\u307e\u3067\u306b\u5897\u52a0\u3057\u3066\u304a\u308a\u3001\u7dda\u866b\u306f\u4eca\u65e5\u3067\u3082\u6297\u8001\u5316\u7814\u7a76\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u308b\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" src=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-1.jpg\" alt=\"\" class=\"wp-image-507\" style=\"width:800px\"\/><figcaption class=\"wp-element-caption\">\u56f3\uff11\uff1a2000\u5e74\u4ee3\u521d\u982d\u307e\u3067\u306e\u6297\u8001\u5316\u7814\u7a76\u306e\u6b74\u53f2<\/figcaption><\/figure>\n<\/div>\n\n\n<p><strong>\u53c2\u8003\u8cc7\u6599<\/strong><br>1\uff09Judith Campisi\u4ed6, \u201cFrom discoveries in ageing research to therapeutics for healthy ageing\u201d(2019) Nature, 571(7764):183-192<br>2\uff09\u77f3\u4e95 \u76f4\u660e, \u8001\u5316\u7814\u7a76\u306e\u30e2\u30c7\u30eb\u52d5\u7269\u3068\u3057\u3066\u306e\u7dda\u866b, Canorhabditis elegans (\u7dcf\u8aac) (2017) \u6771\u6d77\u5927\u5b66\u5148\u9032\u751f\u547d\u79d1\u5b66\u7814\u7a76\u6240\u7d00\u8981 \u7b2c1\u5dfb<\/p>\n\n\n\n<p><strong>\u76e3\u4fee\u8005<\/strong><br>\u5800\u5ddd\u3000\u8aa0\u3000<br>1982\u5e74\u5927\u962a\u5e9c\u751f\u307e\u308c\u3002\u7b51\u6ce2\u5927\u5b66\u5927\u5b66\u9662\u535a\u58eb\u8ab2\u7a0b\u4fee\u4e86\u3002\u73fe\u5728\u3001\u5948\u826f\u533b\u79d1\u5927\u5b66\u8b1b\u5e2b\u3068\u3057\u3066\u300c\u7dda\u866b\u306e\u51ac\u7720\u69d8\u73fe\u8c61\u306e\u7814\u7a76\u304a\u3088\u3073\u51ac\u7720\u69d8\u73fe\u8c61\u306e\u6297\u8001\u5316\u7814\u7a76\u3078\u306e\u5fdc\u7528\u300d\u306b\u95a2\u3059\u308b\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p class=\"has-text-align-right has-small-font-size\">\u00a92026 \u866b\u306e\u96c6\u3044\uff08\u7dda\u866b\u7814\u7a76\u8005\u30b3\u30df\u30e5\u30cb\u30c6\u30a3\uff09\u300c1.\u3000\u7dda\u866b\u304b\u3089\u898b\u308b\u6297\u8001\u5316\u7814\u7a76\u306e\u6b74\u53f2\u300d<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">CC BY<\/a><\/p>\n\n\n\n<p class=\"has-text-align-right\"><a href=\"#toc_container\">\u76ee\u6b21\u30da\u30fc\u30b8\u3078\u2191<\/a><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div><\/section>\n\n\n\n<section id=\"section-2\" class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h3 class=\"wp-block-heading\">2.\u3000\u7dda\u866b\u3092\u7528\u3044\u305f\u5bff\u547d\u6e2c\u5b9a\u3068\u6297\u8001\u5316\u7814\u7a76<\/h3>\n\n\n\n<h4 class=\"wp-block-heading has-text-align-left\">\u7dda\u866b<em>C. elegans<\/em>\u306e\u5bff\u547d\u6e2c\u5b9a\u65b9\u6cd5<\/h4>\n\n\n\n<p>\u7dda\u866b\uff08<em>C. elegans<\/em>\uff09\u306f\u5bff\u547d\u304c20\u65e5\u7a0b\u5ea6\u3068\u4ed6\u306e\u30e2\u30c7\u30eb\u751f\u7269\u3088\u308a\u77ed\u304f\u3001\u907a\u4f1d\u5b66\u7684\u64cd\u4f5c\u304c\u3057\u3084\u3059\u3044\u305f\u3081\u3001\u8001\u5316\u30fb\u5bff\u547d\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7814\u7a76\u306b\u3068\u3066\u3082\u5411\u3044\u3066\u3044\u308b\u751f\u7269\u3067\u3059\u3002\u7dda\u866b\u306e\u5bff\u547d\u306f\u3001\u7c21\u5358\u306b\u8a00\u3048\u3070\u3001\u7dda\u866b\u306e\u751f\u5b58\u3057\u305f\u65e5\u6570\u3067\u6e2c\u5b9a\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u5bff\u547d\u6e2c\u5b9a\u3067\u306f\u3001\u307e\u305a\u5e7c\u866b\u304b\u3089\u6210\u866b\u3078\u3068\u6210\u9577\u3057\u3088\u3046\u3068\u3057\u3066\u3044\u308b\u30bf\u30a4\u30df\u30f3\u30b0\u306e\u7dda\u866b(\u82e5\u5e74\u7dda\u866b)\u3092\u65b0\u3057\u3044\u57f9\u5730\u306b\u79fb\u52d5\u3055\u305b\u307e\u3059\u3002\u3053\u306e\u3068\u304d\u3001\u6210\u866b\u306b\u306a\u3063\u305f\u7dda\u866b\u304c\u5375\u3092\u7523\u3093\u3067\u5b50\u3084\u5b6b\u306b\u307e\u304e\u308c\u3066\u3057\u307e\u308f\u306a\u3044\u3088\u3046\u306b\u3001\u5375\u3092\u7523\u3080\u671f\u9593\u304c\u7d42\u308f\u308b\u307e\u3067\u6bce\u65e5\u79fb\u52d5\u3055\u305b\u308b\u304b\u3001\u7523\u5375\u6291\u5236\u5264\u3092\u57f9\u5730\u306b\u6dfb\u52a0\u3059\u308b\u304b\u3057\u3066\u304a\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u6b21\u306b\u3001\u7dda\u866b\u304c\u6b7b\u3093\u3067\u52d5\u304b\u306a\u304f\u306a\u308b\u307e\u3067\u6bce\u65e5\u89b3\u5bdf\u3057\u307e\u3059\u3002\u7dda\u866b\u304c\u52d5\u3044\u3066\u3044\u308b\u304b\u3069\u3046\u304b\u3092\u78ba\u8a8d\u3059\u308b\u306b\u306f\u3001\u9855\u5fae\u93e1\u3067\u6ce8\u610f\u6df1\u304f\u89b3\u5bdf\u3057\u305f\u308a\u3001\u767d\u91d1\u8033\u306a\u3069\u306e\u5c02\u7528\u306e\u9053\u5177\u3067\u8efd\u304f\u89e6\u308c\u3066\u52d5\u304f\u304b\u3069\u3046\u304b\u3092\u8abf\u3079\u305f\u308a\u3057\u307e\u3059\u3002\u53cd\u5fdc\u304c\u306a\u3051\u308c\u3070\u305d\u306e\u7dda\u866b\u306f\u6b7b\u3093\u3060\u3068\u5224\u65ad\u3055\u308c\u307e\u3059\u3002\u3053\u308c\u3092\u3059\u3079\u3066\u306e\u7dda\u866b\u306b\u3064\u3044\u3066\u8a18\u9332\u3057\u3001\u6700\u5f8c\u306b\u30c7\u30fc\u30bf\u3092\u307e\u3068\u3081\u308b\u3068\u300c\u5e73\u5747\u5bff\u547d\u300d\u3084\u300c\u6700\u5927\u5bff\u547d\u300d\u3092\u8a08\u7b97\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" width=\"908\" height=\"211\" src=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-2_01.png\" alt=\"\" class=\"wp-image-641\" style=\"width:800px\" srcset=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-2_01.png 908w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-2_01-300x70.png 300w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-2_01-768x178.png 768w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-2_01-670x156.png 670w\" sizes=\"(max-width: 908px) 100vw, 908px\" \/><figcaption class=\"wp-element-caption\">\u56f31 \u7dda\u866b\u306e\u5bff\u547d\u6e2c\u5b9a\u65b9\u6cd5<\/figcaption><\/figure>\n<\/div>\n\n\n<h4 class=\"wp-block-heading\">\u7dda\u866b\u3092\u7528\u3044\u305f\u6297\u8001\u5316\u7814\u7a76<\/h4>\n\n\n\n<p>\u5bff\u547d\u306e\u7814\u7a76\u306b\u304a\u3044\u3066\u3001\u6804\u990a\u5931\u8abf\u306b\u306a\u3089\u306a\u3044\u7a0b\u5ea6\u306b\u6804\u990a\u6442\u53d6\u91cf\u3092\u6e1b\u3089\u3059\u300c\u98df\u990c\u5236\u9650\uff08Dietary Restriction\uff09\u300d\u3067\u5bff\u547d\u304c\u5ef6\u3073\u308b\u3053\u3068\u304c\u898b\u51fa\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u52b9\u679c\u306f\u5358\u7d30\u80de\u751f\u7269\u306e\u9175\u6bcd\u304b\u3089\u591a\u7d30\u80de\u751f\u7269\u306e\u7dda\u866b\u3001\u30cf\u30a8\u3001\u30de\u30a6\u30b9\u3001\u970a\u9577\u985e\u307e\u3067\u5e45\u5e83\u3044\u751f\u7269\u3067\u78ba\u8a8d\u3055\u308c\u3066\u304a\u308a\u3001\u9032\u5316\u7684\u306b\u4fdd\u5b58\u3055\u308c\u305f\u3057\u304f\u307f\u304c\u306f\u305f\u3089\u304f\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u7dda\u866b\u306b\u304a\u3044\u3066\u98df\u990c\u5236\u9650\u304c\u5bff\u547d\u3092\u5ef6\u3070\u3059\u3057\u304f\u307f\u3092\u89e3\u660e\u3059\u308c\u3070\u3001\u4eba\u985e\u306e\u5065\u5eb7\u5897\u9032\u3084\u9577\u5bff\u306b\u3082\u3064\u306a\u304c\u308a\u305d\u3046\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u7dda\u866b\u306f\u89e3\u5256\u5b66\u7684\u306b\u5358\u7d14\u306a\u69cb\u9020\u3092\u6301\u3061\u306a\u304c\u3089\u3082\u3001\u30d2\u30c8\u3068\u5171\u901a\u3059\u308b\u6a5f\u80fd\u3092\u6301\u3064\u907a\u4f1d\u5b50\u304c\u6570\u591a\u304f\u5b58\u5728\u3057\u3001\u7dda\u866b\u3092\u7528\u3044\u305f\u7814\u7a76\u306b\u3088\u3063\u3066\u3001\u5bff\u547d\u3092\u5236\u5fa1\u3059\u308b\u305f\u3081\u306e\u3001\u751f\u7269\u306b\u5171\u901a\u3057\u305f\u3057\u304f\u307f\u304c\u89e3\u660e\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u307e\u3067\u306b\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\/IGF-1\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3068\u547c\u3070\u308c\u308b\u3001\u7d30\u80de\u304c\u6804\u990a\u3092\u611f\u77e5\u3059\u308b\u6a5f\u80fd\u306e\u4f4e\u4e0b\u304c\u3001\u98df\u990c\u5236\u9650\u306b\u3088\u308b\u5bff\u547d\u5ef6\u9577\u306b\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u98df\u990c\u5236\u9650\u3084\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306b\u3088\u308a\u3053\u306e\u7d4c\u8def\u306e\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3001\u4ee3\u8b1d\u3084\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u3092\u8abf\u7bc0\u3057\u3066\u3001\u4f53\u306e\u4e0d\u8981\u306a\u6210\u5206\u3092\u5206\u89e3\u3057\u3066\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u5f97\u308b\u305f\u3081\u306e\u300c\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u300d\u3068\u547c\u3070\u308c\u308b\u3057\u304f\u307f\u3092\u6d3b\u6027\u5316\u3057\u305f\u308a\u3001\u30b9\u30c8\u30ec\u30b9\u3092\u8efd\u6e1b\u3059\u308b\u3088\u3046\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u3064\u304f\u308a\u3060\u3057\u305f\u308a\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u8001\u5316\u3092\u9045\u3089\u305b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" width=\"1971\" height=\"657\" src=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-2_02.jpg\" alt=\"\" class=\"wp-image-534\" style=\"width:800px\" srcset=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-2_02.jpg 1971w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-2_02-300x100.jpg 300w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-2_02-1024x341.jpg 1024w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-2_02-768x256.jpg 768w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-2_02-1536x512.jpg 1536w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-2_02-670x223.jpg 670w\" sizes=\"(max-width: 1971px) 100vw, 1971px\" \/><figcaption class=\"wp-element-caption\">\u56f32 \u98df\u990c\u5236\u9650\u3068<em>daf-2<\/em>\u5909\u7570\u306b\u3088\u308b\u5bff\u547d\u5ef6\u9577<\/figcaption><\/figure>\n<\/div>\n\n\n<h4 class=\"wp-block-heading\">\u7dda\u866b\u306b\u3088\u308b\u6700\u8fd1\u306e\u6297\u8001\u5316\u7814\u7a76<\/h4>\n\n\n\n<p>\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001\u5bff\u547d\u3092\u8abf\u7bc0\u3059\u308b\u5206\u5b50\u3068\u3057\u3066\u300cmTOR\u300d\u3084\u300cAMPK\u300d\u3068\u547c\u3070\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306f\u7d30\u80de\u304c\u6804\u990a\u3084\u30a8\u30cd\u30eb\u30ae\u30fc\u306e\u72b6\u614b\u3092\u611f\u77e5\u3057\u3001\u305d\u306e\u72b6\u6cc1\u306b\u5fdc\u3058\u3066\u4f53\u5168\u4f53\u306e\u4ee3\u8b1d\u3084\u6210\u9577\u3092\u8abf\u7bc0\u3059\u308b\u30b9\u30a4\u30c3\u30c1\u306e\u3088\u3046\u306a\u5f79\u5272\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u514d\u75ab\u6291\u5236\u5264\u30e9\u30d1\u30de\u30a4\u30b7\u30f3\u306e\u6a19\u7684\u56e0\u5b50\u3068\u3057\u3066\u3082\u77e5\u3089\u308c\u3066\u3044\u308bmTOR\u306f\u3001\u6804\u990a\u304c\u3058\u3085\u3046\u3076\u3093\u306b\u3042\u308b\u3068\u304d\u306b\u6d3b\u6027\u3092\u6301\u3061\u3001\u7d30\u80de\u306e\u6210\u9577\u3084\u5897\u6b96\u3092\u4fc3\u9032\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\u3067\u3059\u304c\u3001\u98df\u990c\u5236\u9650\u3092\u3059\u308b\u3068\u3053\u306emTOR\u306e\u306f\u305f\u3089\u304d\u304c\u6291\u5236\u3055\u308c\u307e\u3059\u3002\u305d\u306e\u7d50\u679c\u3001\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306e\u6d3b\u6027\u5316\u3084\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u306e\u7372\u5f97\u306a\u3069\u306b\u3088\u3063\u3066\u3001\u7d30\u80de\u304c\u9577\u304f\u5065\u5eb7\u72b6\u614b\u3092\u4fdd\u3066\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4e00\u65b9\u3001AMPK\u306f\u98df\u990c\u5236\u9650\u306a\u3069\u3067\u7d30\u80de\u5185\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u901a\u8ca8\u3068\u3057\u3066\u77e5\u3089\u308c\u308bATP\u304c\u4e0d\u8db3\u3057\u305f\u3068\u304d\u306b\u6d3b\u6027\u5316\u3057\u3001\u7d30\u80de\u304c\u7121\u99c4\u306a\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u6d88\u8cbb\u3057\u306a\u3044\u3088\u3046\u306b\u306f\u305f\u3089\u304d\u304b\u3051\u307e\u3059\u3002\u7dda\u866b\u3092\u4f7f\u3063\u305f\u7814\u7a76\u3067\u306f\u3001AMPK\u304c\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3067\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u306f\u305f\u3089\u304d\u3092\u8abf\u6574\u3057\u3001\u5bff\u547d\u3092\u5ef6\u3070\u3059\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u8fd1\u5e74\u3001mTOR\u3084AMPK\u306e\u6d3b\u6027\u3092\u8abf\u7bc0\u3057\u3066\u5bff\u547d\u3092\u5ef6\u3070\u3059\u5316\u5408\u7269\u3084\u4ee3\u8b1d\u7269\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306f\u98df\u990c\u5236\u9650\u3092\u884c\u308f\u306a\u304f\u3066\u3082\u3001\u540c\u69d8\u306b\u5bff\u547d\u5ef6\u9577\u306e\u52b9\u679c\u3092\u3082\u305f\u3089\u3059\u305f\u3081\u3001\u5065\u5eb7\u5bff\u547d\u3092\u5ef6\u3070\u3059\u65b0\u3057\u3044\u30a2\u30d7\u30ed\u30fc\u30c1\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u8178\u5185\u7d30\u83cc\u304c\u7523\u751f\u3059\u308b\u4ee3\u8b1d\u7269\u304cmTOR\u3084AMPK\u306e\u306f\u305f\u3089\u304d\u3092\u9593\u63a5\u7684\u306b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3057\u3001\u8001\u5316\u3092\u9045\u3089\u305b\u308b\u53ef\u80fd\u6027\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u8178\u5185\u7d30\u83cc\u3068\u4ee3\u8b1d\u7269\u306e\u95a2\u4fc2\u6027\u306f\u3001\u7dda\u866b\u306b\u9650\u3089\u305a\u30d2\u30c8\u306b\u3082\u5171\u901a\u3059\u308b\u73fe\u8c61\u3067\u3042\u308b\u3068\u4e88\u60f3\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3057\u304b\u3057\u3001mTOR\u3084AMPK\u304c\u3069\u306e\u3088\u3046\u306b\u8001\u5316\u3092\u6291\u5236\u3059\u308b\u304b\u306b\u3064\u3044\u3066\u306f\u307e\u3060\u3058\u3085\u3046\u3076\u3093\u306b\u5206\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3002\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001mTOR\u306b\u3088\u3063\u3066\u6d3b\u6027\u5316\u3059\u308b\u6a5f\u80fd\u306e\u4e2d\u306b\u3082\u3001\u5bff\u547d\u5ef6\u9577\u306b\u95a2\u4e0e\u3059\u308b\u5f79\u5272\u304c\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u3053\u306e\u3053\u3068\u304b\u3089\u3001\u5bff\u547d\u8abf\u7bc0\u5206\u5b50\u304c\u3069\u306e\u3088\u3046\u306b\u5bff\u547d\u3092\u5236\u5fa1\u3059\u308b\u306e\u304b\u3001\u305d\u306e\u3057\u304f\u307f\u3092\u8a73\u7d30\u306b\u660e\u3089\u304b\u306b\u3057\u3066\u3044\u304f\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002\u7dda\u866b\u3068\u3044\u3046\u5c0f\u3055\u306a\u751f\u7269\u304b\u3089\u5f97\u3089\u308c\u308b\u77e5\u898b\u304c\u3001\u3044\u3064\u304b\u6709\u671b\u306a\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u6cd5\u3092\u3082\u305f\u3089\u3057\u3001\u79c1\u305f\u3061\u306e\u5065\u5eb7\u5bff\u547d\u3092\u5ef6\u3070\u3057\u3066\u304f\u308c\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" width=\"1165\" height=\"1164\" src=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-2_03.jpg\" alt=\"\" class=\"wp-image-535\" style=\"width:400px\" srcset=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-2_03.jpg 1165w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-2_03-300x300.jpg 300w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-2_03-1024x1024.jpg 1024w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-2_03-150x150.jpg 150w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-2_03-768x767.jpg 768w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-2_03-670x669.jpg 670w\" sizes=\"(max-width: 1165px) 100vw, 1165px\" \/><figcaption class=\"wp-element-caption\">\u56f33 \u98df\u990c\u5236\u9650\u306b\u3088\u308b\u5bff\u547d\u5ef6\u9577\u30e1\u30ab\u30cb\u30ba\u30e0<\/figcaption><\/figure>\n<\/div>\n\n\n<p><strong>\u53c2\u8003\u8cc7\u6599<\/strong><br>1\uff09George L Sutphin and Matt Kaeberlein\u8457\u300cMeasuring Caenorhabditis elegans Life Span on Solid Media\u300d\u30012009\u5e74\u3000J. Vis. Exp., 12: 1152\u3001doi: 10.3791\/1152<br>2\uff09Cynthia Kenyon\u3089\u8457\u300cA C. elegans mutant that lives twice as long as wild type\u300d\u30011993\u5e74\u3000Nature, 366: 461\u2013464\u3001doi: 10.1038\/366461a0<br>3\uff09Pankaj Kapahi\u3089\u8457\u300cDietary restriction and lifespan: Lessons from invertebrate models\u300d\u30012017\u5e74\u3000Ageing Res. Rev., 39: 3-14\u3001doi: 10.1016\/j.arr.2016.12.005<br>4\uff09T Keith Blackwell\u3089\u8457\u300cTOR Signaling in Caenorhabditis elegans Development, Metabolism, and Aging\u300d\u30012019\u5e74\u3000Genetics, 213: 329-360\u3001doi: 10.1534\/genetics.119.302504<br>5\uff09Kathrine B Dall and Nils J F\u00e6rgeman\u8457\u300cMetabolic regulation of lifespan from a C. elegans perspective\u300d\u30012019\u5e74\u3000Genes Nutr., 14: 25\u3001doi: 10.1186\/s12263-019-0650-x<br>6\uff09Caroline Heintz and William Mair\u8457\u300cYou Are What You Host: Microbiome Modulation of the Aging Process\u300d\u30012014\u5e74\u3000Cell, 156: 408-411\u3001doi: 10.1016\/j.cell.2014.01.025<br>7\uff09Takafumi Ogawa\u3089\u8457\u300cNutrient control of growth and metabolism through mTORC1 regulation of mRNA splicing\u300d\u30012024\u5e74\u3000Mol. Cell, 84: 4558-4575.E8\u3001doi: 10.1016\/j.molcel.2024.10.037<\/p>\n\n\n\n<p><strong>\u76e3\u4fee\u8005<\/strong><br>\u6c34\u6cbc\u3000\u6b63\u6a39<br>\u5e83\u5cf6\u5927\u5b66\u5927\u5b66\u9662\u7d71\u5408\u751f\u547d\u79d1\u5b66\u7814\u7a76\u79d1\u751f\u7269\u5de5\u5b66\u30d7\u30ed\u30b0\u30e9\u30e0\u5065\u5eb7\u9577\u5bff\u5b66\u7814\u7a76\u5ba4\u3000\u6559\u6388<br><br>\u5c0f\u5ddd\u3000\u8cb4\u53f2<br>\u5e83\u5cf6\u5927\u5b66\u5927\u5b66\u9662\u7d71\u5408\u751f\u547d\u79d1\u5b66\u7814\u7a76\u79d1\u751f\u7269\u5de5\u5b66\u30d7\u30ed\u30b0\u30e9\u30e0\u5065\u5eb7\u9577\u5bff\u5b66\u7814\u7a76\u5ba4\u3000\u52a9\u6559<\/p>\n\n\n\n<p><strong>\u7814\u7a76\u5ba4HP<\/strong><br><a href=\"https:\/\/namihei.hiroshima-u.ac.jp\">https:\/\/namihei.hiroshima-u.ac.jp<\/a><\/p>\n\n\n\n<p class=\"has-text-align-right has-small-font-size\">\u00a92026 \u866b\u306e\u96c6\u3044\uff08\u7dda\u866b\u7814\u7a76\u8005\u30b3\u30df\u30e5\u30cb\u30c6\u30a3\uff09\u300c2.\u3000\u7dda\u866b\u3092\u7528\u3044\u305f\u5bff\u547d\u6e2c\u5b9a\u3068\u6297\u8001\u5316\u7814\u7a76\u300d<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">CC BY<\/a><\/p>\n\n\n\n<p class=\"has-text-align-right\"><a href=\"#toc_container\">\u76ee\u6b21\u30da\u30fc\u30b8\u3078\u2191<\/a><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div><\/section>\n\n\n\n<section id=\"section-3\" class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h3 class=\"wp-block-heading\">3.\u3000\u8001\u5316\u3067\u8d77\u3053\u308b\u4f53\u306e\u5909\u5316<\/h3>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:60%\">\n<h4 class=\"wp-block-heading\">\u640d\u50b7\u3068\u4fee\u5fa9\u306e\u30d0\u30e9\u30f3\u30b9<\/h4>\n\n\n\n<p>\u8001\u5316\u3068\u306f\u3001\u52a0\u9f62\u3068\u3068\u3082\u306b\u500b\u4f53\u3084\u7d44\u7e54\u3001\u5668\u5b98\u306e\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u3067\u3059\u3002\u7dda\u866b\u3067\u306f\u8001\u5316\u306b\u3088\u3063\u3066\u904b\u52d5\u80fd\u529b\u306e\u4f4e\u4e0b\u3084\u3001\u6d88\u5316\u7ba1\u306e\u6a5f\u80fd\u4e0d\u5168\u3001\u3055\u3089\u306b\u306f\u500b\u4f53\u306e\u6b7b\u304c\u8d77\u3053\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3067\u306f\u306a\u305c\u6a5f\u80fd\u4f4e\u4e0b\u304c\u8d77\u3053\u308b\u306e\u3067\u3057\u3087\u3046\u304b\u3002\u7d44\u7e54\u3084\u5668\u5b98\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u591a\u304f\u306e\u90e8\u54c1\u304b\u3089\u4f5c\u3089\u308c\u305f\u3001\u3068\u3066\u3082\u8907\u96d1\u306a\u7cbe\u5bc6\u6a5f\u68b0\u306e\u3088\u3046\u306a\u3082\u306e\u3067\u3059\u3002\u3053\u306e\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u3084\u3001\u8102\u8cea\u3001\u7cd6\u3001\u6838\u9178\u306a\u3069\u306e\u90e8\u54c1\u304c\u6642\u9593\u3068\u3068\u3082\u306b\u640d\u50b7\u3059\u308b\u3053\u3068\u304c\u3001\u8001\u5316\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:40%\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"1036\" height=\"808\" src=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-3_01.jpg\" alt=\"\" class=\"wp-image-540\" srcset=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-3_01.jpg 1036w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-3_01-300x234.jpg 300w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-3_01-1024x799.jpg 1024w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-3_01-768x599.jpg 768w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-3_01-670x523.jpg 670w\" sizes=\"(max-width: 1036px) 100vw, 1036px\" \/><\/figure>\n<\/div><\/div>\n<\/div>\n\n\n\n<p>\u4e00\u65b9\u3067\u3001\u6b63\u5e38\u306a\u6a5f\u80fd\u3092\u4fdd\u3064\u305f\u3081\u306b\u90e8\u54c1\u306e\u5165\u308c\u66ff\u3048\u3082\u884c\u308f\u308c\u3066\u304a\u308a\u3001\u640d\u50b7\u3057\u305f\u90e8\u54c1\u306f\u5206\u89e3\u3055\u308c\u3066\u65b0\u305f\u306a\u90e8\u54c1\u3092\u4f5c\u308b\u6750\u6599\u3068\u306a\u308a\u307e\u3059\u3002\u52a0\u9f62\u3068\u3068\u3082\u306b\u640d\u50b7\u304c\u5897\u3048\u308b\u3068\u3001\u640d\u50b7\u3057\u305f\u90e8\u54c1\u306e\u5206\u89e3\u3082\u6d3b\u767a\u5316\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u52a0\u9f62\u306b\u4f34\u3046\u640d\u50b7\u7b87\u6240\u306e\u5897\u52a0\u304c\u3001\u4fee\u5fa9\u6a5f\u69cb\u306e\u80fd\u529b\u3092\u4e0a\u56de\u308b\u3068\u3001\u640d\u50b7\u304c\u84c4\u7a4d\u3057\u3001\u500b\u4f53\u3084\u7d44\u7e54\u3001\u5668\u5b98\u306e\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u304d\u307e\u3059\u3002\u307e\u305f\u3001\u7dda\u866b<em>C. elegans<\/em>\u306e\u6210\u866b\u3067\u306f\u751f\u6b96\u5de3\u4ee5\u5916\u306b\u306f\u5e79\u7d30\u80de\u304c\u306a\u304f\u3001\u6210\u866b\u3067\u306e\u4f53\u7d30\u80de\u306e\u5165\u308c\u66ff\u308f\u308a\u304c\u306a\u3044\u305f\u3081\u3001\u5206\u5316\u3057\u305f\u7d30\u80de\u306e\u6a5f\u80fd\u4f4e\u4e0b\u304c\u76f4\u63a5\u8001\u5316\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u52a0\u9f62\u3068\u3068\u3082\u306b\u4f53\u306b\u8d77\u3053\u308b\u5909\u5316\u306b\u306f\u3001\u640d\u50b7\u306e\u84c4\u7a4d\u306b\u3088\u308b\u5909\u5316\u3068\u3001\u640d\u50b7\u4fee\u5fa9\u6a5f\u69cb\u304c\u6d3b\u6027\u5316\u3059\u308b\u305f\u3081\u306b\u8d77\u3053\u308b\u5909\u5316\u306e\u3001\u5c11\u306a\u304f\u3068\u3082\uff12\u7a2e\u985e\u304c\u6319\u3052\u3089\u308c\u307e\u3059(\u56f3\uff11)\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading has-text-align-left\">\u5909\u5316\u306f\u78ba\u7387\u7684\u306b\u8d77\u3053\u308b<\/h4>\n\n\n\n<p class=\"mb_30\"><em>C. elegans<\/em>\u306e\u5bff\u547d\u306f\u7814\u7a76\u5ba4\u5185\u3067\u306f\u5e73\u5747\u7d0420\u65e5\u7a0b\u5ea6\u3067\u3059\u3002\u6210\u866b\u306b\u306a\u3063\u30665\u65e5\u7a0b\u5ea6\u3067\u6d88\u5316\u7ba1\u306e\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u59cb\u3081\u3001\uff11\u9031\u9593\u304b\u308910\u65e5\u7a0b\u5ea6\u3067\u4f53\u9577\u304c\u77ed\u304f\u306a\u308a\u904b\u52d5\u80fd\u529b\u304c\u4f4e\u4e0b\u3057\u59cb\u3081\u307e\u3059[1]\u3002\u5f62\u614b\u7684\u306a\u5909\u5316\u3092\u96fb\u5b50\u9855\u5fae\u93e1\u306a\u3069\u3092\u7528\u3044\u3066\u8a73\u3057\u304f\u8abf\u3079\u305f\u7814\u7a76\u3067\u306f\u3001\u52a0\u9f62\u306b\u4f34\u3046\u640d\u50b7\u306f\u78ba\u7387\u7684\u306b\u8d77\u3053\u308b\u3053\u3068\u3001\u7b4b\u8089\u3084\u8868\u76ae\u3001\u8178\u306b\u6bd4\u3079\u3066\u3001\u795e\u7d4c\u7cfb\u3067\u306f\u52a0\u9f62\u306b\u4f34\u3046\u5f62\u614b\u7684\u306a\u5909\u5316\u304c\u5c11\u306a\u3044\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059[2]\u3002<\/p>\n\n\n\n<p class=\"mb_30\">\u307e\u305f\u3001\u7d44\u7e54\u3092\u53d6\u308a\u56f2\u3080\u30b3\u30e9\u30fc\u30b2\u30f3\u3092\u4e3b\u6210\u5206\u3068\u3059\u308b\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9(ECM)\u3082\u3001\u52a0\u9f62\u3068\u5171\u306b\u305d\u306e\u69cb\u6210\u6210\u5206\u304c\u5909\u5316\u3059\u308b\u3053\u3068[3]\u3001\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u306e\u5f37\u5ea6\u304c\u52a0\u9f62\u3068\u3068\u3082\u306b\u4f4e\u4e0b\u3059\u308b\u3053\u3068[4]\u3082\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306b\u3001\u7d30\u80de\u3068\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u304c\u5171\u306b\u52a0\u9f62\u306b\u3088\u308b\u5f71\u97ff\u3092\u53d7\u3051\u307e\u3059\u3002\u30d2\u30c8\u3067\u306f\u52a0\u9f62\u306b\u4f34\u3063\u3066\u8d77\u3053\u308b\u73fe\u8c61\u304c\u5e74\u9f62\u3068\u5171\u306b\u5909\u5316\u3057\u307e\u3059\u3002\u7dda\u866b\u3067\u3082\u52a0\u9f62\u306b\u4f34\u3044\u8d77\u3053\u308b\u5f62\u614b\u5909\u5316\u3084\u6b7b\u4ea1\u7387\u304c\u3001\u8001\u5316\u306e\u30b9\u30c6\u30fc\u30b8\u306b\u3088\u3063\u3066\u7570\u306a\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059[5]\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading has-text-align-left\">\u4fee\u5fa9\u306e\u5165\u308a\u53e3\u3000\u30ea\u30bd\u30bd\u30fc\u30e0\u306e\u6d3b\u6027\u5316<\/h4>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column sp_box_ord_01 is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"1443\" height=\"1108\" src=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-3_02.jpg\" alt=\"\" class=\"wp-image-541\" srcset=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-3_02.jpg 1443w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-3_02-300x230.jpg 300w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-3_02-1024x786.jpg 1024w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-3_02-768x590.jpg 768w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-3_02-670x514.jpg 670w\" sizes=\"(max-width: 1443px) 100vw, 1443px\" \/><\/figure>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<p class=\"has-text-align-left\">\u52a0\u9f62\u306b\u4f34\u3044\u640d\u50b7\u3057\u305f\u90e8\u54c1\uff08\u30bf\u30f3\u30d1\u30af\u8cea\u3001\u8102\u8cea\u3001\u7cd6\u3001\u6838\u9178\u306a\u3069\uff09\u3092\u5206\u89e3\u3059\u308b\u7d30\u80de\u5185\u5c0f\u5668\u5b98\u306f\u30ea\u30bd\u30bd\u30fc\u30e0\u3067\u3059\u3002\u30ea\u30bd\u30bd\u30fc\u30e0\u306f\u5404\u7a2e\u5206\u89e3\u9175\u7d20\u3092\u542b\u3093\u3060\u4e38\u3044\u5f62\u3092\u3057\u305f\u69cb\u9020\u3067\u3001\u4e3b\u306b\u4e0d\u8981\u306b\u306a\u3063\u305f\u3082\u306e\u306e\u5206\u89e3\u3092\u884c\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7dda\u866b\u3067\u306f\u30ea\u30bd\u30bd\u30fc\u30e0\u306e\u5f62\u304c\u52a0\u9f62\u3068\u3068\u3082\u306b\u3001\u4e38\u3044\u5f62\u304b\u3089\u30c1\u30e5\u30fc\u30d6\u72b6\u3078\u3068\u30c0\u30a4\u30ca\u30df\u30c3\u30af\u306b\u5909\u5316\u3057\u3066\u3044\u304d\u307e\u3059[6]\uff08\u56f3\uff12\uff09\u3002\u3053\u306e\u5909\u5316\u306f\u3001\u9577\u5bff\u306e\u5909\u7570\u4f53\u3067\u306f\u9045\u304f\u3001\u77ed\u547d\u306e\u5909\u7570\u4f53\u3067\u306f\u65e9\u304f\u8d77\u3053\u308b\u3053\u3068\u3082\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/div>\n<\/div>\n\n\n\n<p>\u306a\u305c\u30c1\u30e5\u30fc\u30d6\u72b6\u30ea\u30bd\u30bd\u30fc\u30e0\u304c\u5f62\u6210\u3055\u308c\u308b\u306e\u304b\u306b\u3064\u3044\u3066\u306f\u3001\u540c\u8abf\u3057\u3066\u30ea\u30bd\u30bd\u30fc\u30e0\u5168\u4f53\u306e\u6d3b\u6027\u3092\u9ad8\u3081\u308b\u305f\u3081\u3067\u306f\u306a\u3044\u304b\u3001\u8868\u9762\u7a4d\u3092\u5897\u3084\u3057\u3066\u3088\u308a\u591a\u304f\u306e\u8001\u5ec3\u7269\u3092\u53d7\u3051\u5165\u308c\u308b\u305f\u3081\u3067\u306f\u306a\u3044\u304b\u3001\u306a\u3069\u306e\u8aac\u304c\u3042\u308a\u307e\u3059\u304c[7]\u3001\u305d\u306e\u610f\u7fa9\u306f\u308f\u304b\u3063\u3066\u304a\u3089\u305a\u4eca\u5f8c\u306e\u7814\u7a76\u304c\u5f85\u305f\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"has-text-align-left\">\u30c1\u30e5\u30fc\u30d6\u72b6\u306e\u30ea\u30bd\u30bd\u30fc\u30e0\u306f\u8131\u76ae\u3084\u98e2\u9913\u72b6\u614b\u3067\u3082\u5897\u52a0\u3057\u307e\u3059[7, 8]\u3002\u9762\u767d\u3044\u3053\u3068\u306b\u3001\u98e2\u9913\u306b\u3088\u308b\u30c1\u30e5\u30fc\u30d6\u72b6\u30ea\u30bd\u30bd\u30fc\u30e0\u306e\u5897\u52a0\u306f\u3001\u98e2\u9913\u3092\u7d4c\u9a13\u3057\u3066\u3044\u306a\u3044\u5b50\u3084\u5b6b\u306b\u307e\u3067\u53d7\u3051\u7d99\u304c\u308c\u3001\u5bff\u547d\u306e\u5ef6\u9577\u3078\u3068\u3064\u306a\u304c\u308a\u307e\u3059[7]\u3002\u307e\u305f\u3001\u8131\u76ae\u3084\u8001\u5316\u3067\u306f\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u3084\u30b3\u30f3\u30c9\u30ed\u30a4\u30c1\u30f3\u3092\u542b\u3080\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u304c\u3001\u30c1\u30e5\u30fc\u30d6\u72b6\u30ea\u30bd\u30bd\u30fc\u30e0\u306e\u5f62\u6210\u3092\u6291\u3048\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059[8, 9]\u3002\u3053\u306e\u3088\u3046\u306b\u30c1\u30e5\u30fc\u30d6\u72b6\u30ea\u30bd\u30bd\u30fc\u30e0\u304c\u8001\u5316\u3068\u95a2\u4fc2\u3059\u308b\u3053\u3068\u306f\u9593\u9055\u3044\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u5358\u7d14\u306b\u305d\u306e\u5897\u6e1b\u304c\u9577\u5bff\u306b\u3064\u306a\u304c\u308b\u308f\u3051\u3067\u306f\u306a\u3044\u3088\u3046\u3067\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u8001\u5316\u306b\u3088\u308b\u7b4b\u8089\u306e\u6a5f\u80fd\u4f4e\u4e0b\u3000\u30b5\u30eb\u30b3\u30da\u30cb\u30a2\u30e2\u30c7\u30eb<\/h4>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<p>\u8001\u5316\u306b\u4f34\u3046\u7b4b\u8089\u306e\u6a5f\u80fd\u4f4e\u4e0b\u306f\u30b5\u30eb\u30b3\u30da\u30cb\u30a2\u3068\u547c\u3070\u308c\u307e\u3059\u3002<em>C. elegans<\/em>\u306e\u4f53\u58c1\u7b4b\u306f\u3001\u30d2\u30c8\u306e\u9aa8\u683c\u7b4b\u3068\u540c\u3058\u304f\u3001\u4ea4\u4e92\u306b\u4e26\u3093\u3060\u30a2\u30af\u30c1\u30f3\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u3068\u30df\u30aa\u30b7\u30f3\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u304c\u4e26\u884c\u306b\u79fb\u52d5\u3059\u308b\u3053\u3068\u3067\u529b\u3092\u751f\u307f\u51fa\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7b4b\u8089\u306e\u69cb\u9020\u304c\u4f3c\u3066\u3044\u308b\u3053\u3068\u3068\u3001\u8001\u5316\u306b\u4f34\u3046\u7b4b\u8089\u306e\u6a5f\u80fd\u4f4e\u4e0b\u3068\u3044\u3046\u73fe\u8c61\u304c\u5171\u901a\u3057\u3066\u3044\u308b\u3053\u3068\u304b\u3089\u3001<em>C. elegans<\/em>\u306f\u30b5\u30eb\u30b3\u30da\u30cb\u30a2\u30e2\u30c7\u30eb\u3068\u3057\u3066\u4f7f\u308f\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"1141\" height=\"1072\" src=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-3_03.jpg\" alt=\"\" class=\"wp-image-539\" srcset=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-3_03.jpg 1141w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-3_03-300x282.jpg 300w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-3_03-1024x962.jpg 1024w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-3_03-768x722.jpg 768w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-3_03-670x629.jpg 670w\" sizes=\"(max-width: 1141px) 100vw, 1141px\" \/><\/figure>\n<\/div><\/div>\n<\/div>\n\n\n\n<p>\u6210\u866b\u306b\u306a\u3063\u306610\u65e5\u307b\u3069\u3059\u308b\u3068\u3001\u30a2\u30af\u30c1\u30f3\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u306e\u69cb\u9020\u306b\u7570\u5e38\u304c\u898b\u3089\u308c\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059[10]\uff08\u56f3\uff13\uff09\u3002\u307e\u305f\u7b4b\u8089\u3092\u52d5\u304b\u3059\u305f\u3081\u306b\u306f\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u3068\u306a\u308bATP\u304c\u5927\u91cf\u306b\u5fc5\u8981\u3068\u306a\u308a\u307e\u3059\u3002\u7b4b\u8089\u3067\u306fATP\u3092\u4f5c\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304c\u7b4b\u7e4a\u7dad\u306b\u6cbf\u3063\u3066\u7e1e\u72b6\u306e\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u69cb\u9020\u3092\u3068\u308a\u307e\u3059\u3002\u3053\u306e\u7b4b\u8089\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306f\u52a0\u9f62\u3068\u3068\u3082\u306b\u65ad\u7247\u5316\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059[11]\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001<em>C. elegans<\/em>\u306e\u7b4b\u8089\u3067\u306f\u52a0\u9f62\u3068\u3068\u3082\u306b\u7b4b\u7e4a\u7dad\u306e\u69cb\u9020\u305d\u306e\u3082\u306e\u3068\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u4f9b\u7d66\u3059\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306b\u7570\u5e38\u304c\u751f\u3058\u307e\u3059\u3002\u30a2\u30af\u30c1\u30f3\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u306e\u7570\u5e38\u3088\u308a\u3082\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u65ad\u7247\u5316\u306e\u65b9\u304c\u3088\u308a\u65e9\u304f\u8d77\u304d\u308b\u305f\u3081\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u65ad\u7247\u5316\u304c\u52a0\u9f62\u306b\u4f34\u3046\u7b4b\u529b\u4f4e\u4e0b\u306e\u4e3b\u306a\u539f\u56e0\u3067\u3042\u308b\u3068\u3044\u3046\u8aac\u304c\u3042\u308a\u307e\u3059\u3002\u5c11\u306a\u304f\u3068\u3082\u3001\u30a2\u30af\u30c1\u30f3\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u306e\u7570\u5e38\u3068\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u65ad\u7247\u5316\u304c<em>C. elegans<\/em>\u306b\u304a\u3051\u308b\u30b5\u30eb\u30b3\u30da\u30cb\u30a2\u306e\u4e3b\u306a\u539f\u56e0\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u53c2\u8003\u8cc7\u6599<\/strong><\/p>\n\n\n\n<p>1\uff09Shibata, Y., et al., <em>Endogenous chondroitin extends the lifespan and healthspan in C. elegans.<\/em> Sci Rep, 2024. <strong>14<\/strong>(1): p. 4813.<\/p>\n\n\n\n<p>2\uff09Herndon, L.A., et al., <em>Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans.<\/em> Nature, 2002. <strong>419<\/strong>(6909): p. 808-14.<\/p>\n\n\n\n<p>3\uff09Teuscher, A.C., et al., <em>Longevity interventions modulate mechanotransduction and extracellular matrix homeostasis in C. elegans.<\/em> Nat Commun, 2024. <strong>15<\/strong>(1): p. 276.<\/p>\n\n\n\n<p>4\uff09Essmann, C.L., et al., <em>Mechanical properties measured by atomic force microscopy define health biomarkers in ageing C. elegans.<\/em> Nat Commun, 2020. <strong>11<\/strong>(1): p. 1043.<\/p>\n\n\n\n<p>5\uff09Zhao, Y., et al., <em>Two forms of death in ageing Caenorhabditis elegans.<\/em> Nat Commun, 2017. <strong>8<\/strong>: p. 15458.<\/p>\n\n\n\n<p>6\uff09Sun, Y., et al., <em>Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans.<\/em> Elife, 2020. <strong>9<\/strong>.<\/p>\n\n\n\n<p>7\uff09Villalobos, T.V., et al., <em>Tubular lysosome induction couples animal starvation to healthy aging.<\/em> Nat Aging, 2023. <strong>3<\/strong>(9): p. 1091-1106.<\/p>\n\n\n\n<p>8\uff09Miao, R., et al., <em>An ECM-to-Nucleus Signaling Pathway Activates Lysosomes for C. elegans Larval Development.<\/em> Dev Cell, 2020. <strong>52<\/strong>(1): p. 21-37 e5.<\/p>\n\n\n\n<p>9\uff09Shibata, Y., et al., <em>Endogenous chondroitin extends lifespan by inhibiting VHA-7-mediated tubular lysosome formation.<\/em> Sci Rep, 2024. <strong>14<\/strong>(1): p. 29651.<\/p>\n\n\n\n<p>10\uff09Garcia, G., et al., <em>Large-scale genetic screens identify BET-1 as a cytoskeleton regulator promoting actin function and life span.<\/em> Aging Cell, 2023. <strong>22<\/strong>(1): p. e13742.<\/p>\n\n\n\n<p>11\uff09Gaffney, C.J., et al., <em>Greater loss of mitochondrial function with ageing is associated with earlier onset of sarcopenia in C. elegans.<\/em> Aging (Albany NY), 2018. <strong>10<\/strong>(11): p. 3382-3396.<\/p>\n\n\n\n<p><strong>\u76e3\u4fee\u8005<\/strong><br>\u67f4\u7530\u3000\u5e78\u653f<br>1971\u5e74\u751f\u307e\u308c\u3002\u611b\u77e5\u770c\u51fa\u8eab\u3002\u540d\u53e4\u5c4b\u5927\u5b66\u5927\u5b66\u9662\u535a\u58eb\u8ab2\u7a0b\u4fee\u4e86\u3002McGill \u5927\u5b66\u3001\u7406\u5316\u5b66\u7814\u7a76\u6240CDB\u3001\u95a2\u897f\u5b66\u9662\u5927\u5b66\u3092\u3078\u3066\u3001\u73fe\u5728\u306f\u5317\u4eac\u8133\u7814\u7a76\u6240(CIBR)\u52e4\u52d9\u3002\u3044\u308d\u3044\u308d\u306a\u5206\u91ce\u306b\u8208\u5473\u304c\u3042\u308a\u3001\u73fe\u8077\u3067\u306f\u300c\u8001\u5316\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u300d\u3092\u7814\u7a76\u3057\u3066\u3044\u308b\u3002\u5206\u5b50\u751f\u7269\u5b66\u4f1a\u3067\u300cECM\u3068\u8001\u5316\u300d\u306e\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\u3092\u4f01\u753b\u3059\u308b\u3002\u7dda\u866b\u7814\u7a76\u306e\u672a\u6765\u3092\u5275\u308b\u4f1a2023\u306e\u30e1\u30a4\u30f3\u30aa\u30fc\u30ac\u30ca\u30a4\u30b6\u30fc\u3092\u52d9\u3081\u308b\u3002<\/p>\n\n\n\n<p class=\"has-text-align-right has-small-font-size\">\u00a92026 \u866b\u306e\u96c6\u3044\uff08\u7dda\u866b\u7814\u7a76\u8005\u30b3\u30df\u30e5\u30cb\u30c6\u30a3\uff09\u300c3.\u3000\u8001\u5316\u3067\u8d77\u3053\u308b\u4f53\u306e\u5909\u5316\u300d<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">CC BY<\/a><\/p>\n\n\n\n<p class=\"has-text-align-right\"><a href=\"#toc_container\">\u76ee\u6b21\u30da\u30fc\u30b8\u3078\u2191<\/a><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div><\/section>\n\n\n\n<section id=\"section-4\" class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h3 class=\"wp-block-heading\">4.\u3000\u795e\u7d4c\u30fb\u884c\u52d5\u306e\u8001\u5316<\/h3>\n\n\n\n<h4 class=\"wp-block-heading has-text-align-left\">\u884c\u52d5\u306e\u8001\u5316<\/h4>\n\n\n\n<p>\u3000\u7dda\u866b\u306f\u5bd2\u5929\u30d7\u30ec\u30fc\u30c8\u306e\u4e0a\u3092\u4e0a\u624b\u306b\u52d5\u304d\u56de\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u3048\u3055\u306b\u5411\u304b\u3063\u3066\u52b9\u7387\u7684\u306b\u79fb\u52d5\u3057\u3066\u305d\u308c\u3092\u98df\u3079\u3001\u6392\u4fbf\u307e\u3067\u884c\u3044\u307e\u3059\u3002\u305f\u3063\u305f302\u500b\u306e\u795e\u7d4c\u7d30\u80de\u3067\u305d\u308c\u3089\u306e\u69d8\u3005\u306a\u884c\u52d5\u3092\u884c\u3048\u308b\u306e\u306f\u9a5a\u304d\u3067\u3059\uff08\u9805\u76ee3\u53c2\u7167\uff09\u3002\u3057\u304b\u3057\u3001\u6210\u866b\uff08\u751f\u6b96\u53ef\u80fd\u306a\u500b\u4f53\uff09\u306b\u306a\u3063\u3066\u304b\u3089\u52a0\u9f62\u304c\u9032\u3093\u3067\u3044\u304f\u3068\u3001\u3057\u3060\u3044\u306b\u3053\u308c\u3089\u306e\u884c\u52d5\u304c\u3067\u304d\u306a\u304f\u306a\u3063\u3066\u3044\u304d\u307e\u3059<sup>1\uff09<\/sup>\u3002<\/p>\n\n\n\n<p>\u305f\u3068\u3048\u3070\u3001\u6210\u866b\u306b\u306a\u3063\u3066\u304b\u308923\u2103\u30674\u65e5\u7a0b\u5ea6\u98fc\u80b2\u3057\u305f\u7dda\u866b\u3067\u306f\u3001\u904b\u52d5\u6a5f\u80fd\u306e\u4f4e\u4e0b\u306f\u3042\u307e\u308a\u898b\u3089\u308c\u307e\u305b\u3093\u304c\u3001\u3048\u3055\u306e\u5302\u3044\u306b\u5411\u304b\u3046\u5316\u5b66\u8d70\u6027\u884c\u52d5\uff08\u633f\u7d75\uff09\u3084\u3001\u3048\u3055\u3068\u6e29\u5ea6\u306e\u9023\u5408\u5b66\u7fd2\u306a\u3069\u306e\u3001\u6bd4\u8f03\u7684\u8907\u96d1\u306a\u884c\u52d5\u304c\u3067\u304d\u306a\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u52a0\u9f62\u304c\u9032\u3093\u3067\u6210\u866b10\u65e5\u76ee\u3054\u308d\u306b\u306a\u308b\u3068\u3001\u5bd2\u5929\u57f9\u5730\u4e0a\u3067\u306e\u79fb\u52d5\u901f\u5ea6\u304c\u4f4e\u4e0b\u3057\u305f\u308a\u3001\u6c34\u4e2d\u3067\u306e\u3080\u3061\u6253\u3061\u904b\u52d5\u306e\u56de\u6570\u304c\u6e1b\u5c11\u3057\u305f\u308a\u3057\u307e\u3059\u3002\u307e\u305f\u3001\u3048\u3055\u3092\u98df\u3079\u308b\u305f\u3081\u306b\u53e3\u3092\u52d5\u304b\u3059\u30dd\u30f3\u30d4\u30f3\u30b0\u884c\u52d5\u3084\u3001\u6392\u4fbf\u306e\u983b\u5ea6\u3082\u4e0b\u304c\u308a\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u904b\u52d5\u6a5f\u80fd\u306e\u4f4e\u4e0b\u306f\u3001\u7b4b\u8089\u3068\u795e\u7d4c\u7d30\u80de\u306e\u306f\u305f\u3089\u304d\u306b\u6b20\u9665\u304c\u751f\u3058\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u8d77\u3053\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" width=\"2175\" height=\"1088\" src=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-4.jpg\" alt=\"\" class=\"wp-image-556\" style=\"width:800px\" srcset=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-4.jpg 2175w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-4-300x150.jpg 300w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-4-1024x512.jpg 1024w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-4-768x384.jpg 768w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-4-1536x768.jpg 1536w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-4-2048x1024.jpg 2048w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-4-670x335.jpg 670w\" sizes=\"(max-width: 2175px) 100vw, 2175px\" \/><\/figure>\n<\/div>\n\n\n<h4 class=\"wp-block-heading has-text-align-left\">\u795e\u7d4c\u7d30\u80de\u306e\u8001\u5316<\/h4>\n\n\n\n<p>\u7dda\u866b\u306e\u884c\u52d5\u304c\u8001\u5316\u3059\u308b\u539f\u56e0\u306e\u3072\u3068\u3064\u3068\u3057\u3066\u3001\u795e\u7d4c\u6a5f\u80fd\u306e\u4f4e\u4e0b\u304c\u3042\u3052\u3089\u308c\u307e\u3059\u3002\u8133\u5168\u4f53\u306e\u6d3b\u52d5\u3092\u898b\u3066\u307f\u308b\u3068\u3001\u82e5\u3044\u7dda\u866b\u3067\u306f\u795e\u7d4c\u7d30\u80de\u304c\u8208\u596e\u3068\u6291\u5236\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u4fdd\u3063\u3066\u6d3b\u52d5\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u52a0\u9f62\u3057\u305f\u7dda\u866b\u3067\u306f\u3053\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u5d29\u308c\u3066\u3057\u307e\u3046\u3088\u3046\u3067\u3059<sup>2)<\/sup>\u3002\u500b\u3005\u306e\u795e\u7d4c\u7d30\u80de\u306b\u7740\u76ee\u3059\u308b\u3068\u3001\u305f\u3068\u3048\u3070\u3001\u5302\u3044\u7269\u8cea\u3092\u611f\u77e5\u3059\u308b\u795e\u7d4c\u7d30\u80de\u306b\u304a\u3044\u3066\u3001\u5302\u3044\u3078\u306e\u5fdc\u7b54\u6027\u304c\u4f4e\u4e0b\u3059\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059<sup>3\uff09<\/sup>\u3002\u4e00\u65b9\u3001\u52a0\u9f62\u306b\u4f34\u3063\u3066\u795e\u7d4c\u7d30\u80de\u304c\u904e\u5270\u306b\u6d3b\u6027\u5316\u3057\u3066\u3057\u307e\u3044\u3001\u9023\u5408\u5b66\u7fd2\u884c\u52d5\u3092\u963b\u5bb3\u3059\u308b\u4f8b\u3082\u77e5\u3089\u308c\u3066\u3044\u307e\u3059<sup>4)<\/sup>\u3002<\/p>\n\n\n\n<p>\u52a0\u9f62\u304c\u9032\u3080\u3068\u3001\u795e\u7d4c\u7d30\u80de\u306e\u6a5f\u80fd\u306b\u52a0\u3048\u3066\u5f62\u3082\u5909\u5316\u3057\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u795e\u7d4c\u7d30\u80de\u304c\u306e\u3070\u3057\u3066\u3044\u308b\u7a81\u8d77\u304c\u3075\u304f\u3089\u3093\u3060\u308a\u3001\u4f59\u8a08\u306a\u679d\u5206\u304b\u308c\u304c\u3067\u304d\u305f\u308a\u3057\u307e\u3059<sup>5\uff09<\/sup>\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u795e\u7d4c\u7d30\u80de\u306e\u591a\u304f\u306f\u52a0\u9f62\u3057\u3066\u3082\u6b7b\u306c\u3053\u3068\u306f\u306a\u304f\u3001\u5f62\u306e\u5909\u5316\u3082\u7b4b\u8089\u306a\u3069\u306b\u6bd4\u3079\u308b\u3068\u8efd\u5fae\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3067\u306f\u3001\u795e\u7d4c\u7d30\u80de\u306f\u3069\u306e\u3088\u3046\u306b\u8001\u5316\u3057\u3066\u884c\u52d5\u306e\u5909\u5316\u3092\u5f15\u304d\u8d77\u3053\u3059\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n\n\n\n<p>\u7dda\u866b\u3092\u7528\u3044\u305f\u7814\u7a76\u306b\u3088\u308a\u3001\u500b\u4f53\u306e\u5bff\u547d\u3092\u5236\u5fa1\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u5f90\u3005\u306b\u660e\u3089\u304b\u306b\u306a\u308a\u3064\u3064\u3042\u308a\u307e\u3059\u304c\uff08\u9805\u76ee\uff14\uff0d\uff12\u53c2\u7167\uff09\u3001\u795e\u7d4c\u7d30\u80de\u306e\u8001\u5316\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u306f\u307e\u3060\u307e\u3060\u591a\u304f\u306e\u8b0e\u304c\u6b8b\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u5bff\u547d\u7814\u7a76\u306b\u304a\u3051\u308b\u6210\u679c\u306e\u84c4\u7a4d\u3068\u3001\u795e\u7d4c\u7d30\u80de\u3084\u884c\u52d5\u306e\u7814\u7a76\u306b\u304a\u3051\u308b\u7dda\u866b\u306e\u5229\u70b9\u3092\u3044\u304b\u3057\u3066\u3001\u4eca\u5f8c\u3055\u3089\u306b\u7814\u7a76\u304c\u9032\u3080\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u53c2\u8003\u8cc7\u6599<\/strong><br>1\uff09James J. Collins\u3089\u8457\u3001\u300cThe measurement and analysis of age-related changes in <em>Caenorhabditis elegans<\/em>\u300d\u30012007\u5e74\u3001Wormbook\u3001doi\/10.1895\/wormbook.1.137.1<br>2\uff09Gregory S Wirak\u3089\u8457\u3001\u300cAge-associated changes to neuronal dynamics involve a disruption of excitatory\/inhibitory balance in <em>C. elegans<\/em>\u300d\u30012022\u5e74\u3001eLife\u300111:e72135\u3001doi: 10.7554\/eLife.72135<br>3\uff09Sarah G Leinwand\u3089\u8457\u3001\u300cCircuit mechanisms encoding odors and driving aging-associated behavioral declines in <em>Caenorhabditis elegans<\/em>\u300d\u30012015\u5e74\u3001eLife\u30014:e10181\u3001doi.org\/10.7554\/eLife.10181<br>4\uff09Chun-Liang Pan\u3089\u8457\u3001\u300cGenetic analysis of age-dependent defects of the <em>Caenorhabditis elegans <\/em>touch receptor neurons\u300d\u30012011\u5e74\u3001PNAS\u3001108 (22) 9274-9279\u3001doi.org\/10.1073\/pnas.1011711108<\/p>\n\n\n\n<p><strong>\u76e3\u4fee\u8005<\/strong><br>\u91ce\u9593\u3000\u5065\u592a\u90ce\u30001982\u5e74\u9999\u5ddd\u770c\u751f\u307e\u308c\u3002\u4eac\u90fd\u5927\u5b66 \u5927\u5b66\u9662\u535a\u58eb\u8ab2\u7a0b\u4fee\u4e86\u3002\u73fe\u5728\u3001\u540d\u53e4\u5c4b\u5927\u5b66\u51c6\u6559\u6388\u3068\u3057\u3066\u3001\u884c\u52d5\u8001\u5316\u306e\u907a\u4f1d\u7684\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p><strong>\u7814\u7a76\u5ba4HP<\/strong><br><a href=\"https:\/\/nomatode.com\">https:\/\/nomatode.com<\/a><\/p>\n\n\n\n<p class=\"has-text-align-right has-small-font-size\">\u00a92026 \u866b\u306e\u96c6\u3044\uff08\u7dda\u866b\u7814\u7a76\u8005\u30b3\u30df\u30e5\u30cb\u30c6\u30a3\uff09\u300c4.\u3000\u795e\u7d4c\u30fb\u884c\u52d5\u306e\u8001\u5316\u300d<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">CC BY<\/a><\/p>\n\n\n\n<p class=\"has-text-align-right\"><a href=\"#toc_container\">\u76ee\u6b21\u30da\u30fc\u30b8\u3078\u2191<\/a><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div><\/section>\n\n\n\n<section id=\"section-5\" class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h3 class=\"wp-block-heading\">5.\u3000\u7dda\u866b\u3067\u795e\u7d4c\u306e\u75c5\u6c17\u3092\u8abf\u3079\u308b<\/h3>\n\n\n\n<h4 class=\"wp-block-heading has-text-align-left\">\u795e\u7d4c\u75be\u60a3\u306e\u7814\u7a76\u306b\u7dda\u866b\u3092\u4f7f\u3048\u308b\u306e\uff1f<\/h4>\n\n\n\n<p>\u3000\u3053\u3053\u3067\u306f\u3001\u7dda\u866b<em>C. elegans<\/em>\u3092\u4f7f\u3063\u3066\u3001\u75c5\u6c17\u3001\u7279\u306b\u795e\u7d4c\u75be\u60a3\u304c\u3069\u306e\u3088\u3046\u306b\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u306e\u304b\u3092\u8abf\u3079\u3066\u3001\u898b\u3064\u304b\u3063\u305f\u767a\u898b\u3092\u30d2\u30c8\u306e\u75c5\u6c17\u306e\u6cbb\u7642\u306b\u5f79\u7acb\u3066\u3088\u3046\u3068\u3059\u308b\u7814\u7a76\u306b\u3064\u3044\u3066\u7d39\u4ecb\u3057\u307e\u3059\u3002<br>\u7dda\u866b\u3092\u795e\u7d4c\u75be\u60a3\u306e\u30e2\u30c7\u30eb\u3068\u3057\u3066\u4f7f\u7528\u3059\u308b\u5229\u70b9\u306f\u3001\u6271\u3044\u304c\u7c21\u4fbf\u3067\u3042\u308b\u3053\u3068\u3068\u3001\u4e16\u4ee3\u4ea4\u4ee3\u304c\u901f\u3044\u3053\u3068\u3067\u3001\u3053\u306e\u305f\u3081\u907a\u4f1d\u5b50\u64cd\u4f5c\u3084\u85ac\u5264\u306e\u52b9\u679c\u3092\u8fc5\u901f\u306b\u8a55\u4fa1\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u307e\u305f\u3001\u7dda\u866b\u306e\u795e\u7d4c\u7cfb\u306f\u6bd4\u8f03\u7684\u5358\u7d14\u3067\u3042\u308a\u306a\u304c\u3089\u3001\u30d2\u30c8\u306e\u795e\u7d4c\u7cfb\u3068\u591a\u304f\u306e\u5171\u901a\u70b9\u3092\u6301\u3064\u305f\u3081\u3001\u7279\u5b9a\u306e\u795e\u7d4c\u75be\u60a3\u306e\u57fa\u790e\u7684\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u660e\u3059\u308b\u306e\u306b\u975e\u5e38\u306b\u6709\u7528\u3067\u3059\u3002<br>\u305f\u3068\u3048\u3070\u3001\u30d2\u30c8\u306e\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3084\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3001\u7b4b\u840e\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7(ALS)\u306a\u3069\u306e\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u7814\u7a76\u306b\u7dda\u866b\u306f\u3088\u304f\u7528\u3044\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u7406\u7531\u306f\u3001\u75be\u60a3\u306e\u539f\u56e0\u3068\u306a\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u898b\u3064\u304b\u3063\u3066\u3044\u3066\u3001\u305d\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u7dda\u866b\u306e\u795e\u7d4c\u7d30\u80de\u306b\u5c0e\u5165\u3059\u308b\u3053\u3068\u3067\u3001\u30d2\u30c8\u3068\u540c\u3058\u3088\u3046\u306b\u795e\u7d4c\u7d30\u80de\u304c\u6b7b\u3093\u3060\u308a\u795e\u7d4c\u6a5f\u80fd\u304c\u5931\u308f\u308c\u305f\u308a\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u308b\u304b\u3089\u3067\u3059\u3002\u305d\u306e\u4e00\u65b9\u3067\u3001\u9650\u754c\u3082\u3042\u308a\u3001\u7d71\u5408\u5931\u8abf\u75c7\u3084\u3046\u3064\u75c5\u306a\u3069\u3001\u30d2\u30c8\u306b\u7279\u6709\u306e\u8907\u96d1\u306a\u884c\u52d5\u3084\u611f\u60c5\u306b\u95a2\u9023\u3059\u308b\u75be\u60a3\u306e\u7814\u7a76\u306b\u7dda\u866b\u3092\u7528\u3044\u308b\u306e\u306f\u96e3\u3057\u3044\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading has-text-align-left\">\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3068\u7dda\u866b<\/h4>\n\n\n\n<p>\u3000\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3067\u306f\u3001\u539f\u56e0\u3068\u306a\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u7570\u5e38\u306b\u96c6\u307e\u3063\u3066\u3067\u304d\u308b\u51dd\u96c6\u4f53\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3059\u3002\u539f\u56e0\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u75be\u60a3\u306b\u3088\u3063\u3066\u3055\u307e\u3056\u307e\u3067\u3001\u305f\u3068\u3048\u3070\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3067\u306f\u30a2\u30df\u30ed\u30a4\u30c9\u30d9\u30fc\u30bf\u3084\u30bf\u30a6\u306a\u3069\u3001ALS\u3067\u306fTDP-43\u306a\u3069\u306e\u539f\u56e0\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u51dd\u96c6\u4f53\u3092\u4f5c\u308a\u307e\u3059\u3002\u3053\u3046\u3057\u305f\u51dd\u96c6\u4f53\u304c\u5f62\u6210\u3055\u308c\u308b\u3068\u3001\u795e\u7d4c\u7d30\u80de\u306e\u4e2d\u3067\u3044\u308d\u3044\u308d\u306a\u7570\u5e38\u304c\u5f15\u304d\u8d77\u3053\u3055\u308c\u307e\u3059\u3002\u7dda\u866b\u3092\u4f7f\u3063\u305f\u7814\u7a76\u3067\u3001\u3053\u306e\u51dd\u96c6\u4f53\u304c\u5f15\u304d\u8d77\u3053\u3059\u7570\u5e38\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u304c\u898b\u3064\u304b\u308a\u3001\u75be\u60a3\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u8abf\u3079\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002<br>\u305d\u308c\u3067\u3082\u3001\u307e\u3060\u307e\u3060\u308f\u304b\u3063\u3066\u3044\u306a\u3044\u3053\u3068\u306f\u305f\u304f\u3055\u3093\u3042\u308a\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u8fd1\u5e74\u3001\u7d30\u80de\u306e\u4e2d\u3067\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u300c\u6c34\u306b\u6d6e\u304b\u3076\u6cb9\u300d\u306e\u3088\u3046\u306b\u7403\u72b6\u306b\u96c6\u307e\u308b\u73fe\u8c61\uff08\u6db2-\u6db2\u76f8\u5206\u96e2\uff09\u304c\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3068\u95a2\u9023\u3059\u308b\u3053\u3068\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u3053\u306e\u73fe\u8c61\u304c\u3069\u306e\u3088\u3046\u306b\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3092\u5f15\u304d\u8d77\u3053\u3057\u3066\u3044\u308b\u306e\u304b\u306b\u3064\u3044\u3066\u306f\u4e0d\u660e\u306a\u70b9\u304c\u307e\u3060\u591a\u304f\u6b8b\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u8001\u5316\u304c\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u767a\u75c7\u306e\u5f15\u304d\u91d1\u3068\u306a\u3063\u3066\u3044\u308b\u3053\u3068\u306f\u9593\u9055\u3044\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u305d\u308c\u304c\u6db2-\u6db2\u76f8\u5206\u96e2\u3068\u3069\u306e\u3088\u3046\u306b\u95a2\u4fc2\u3059\u308b\u306e\u304b\u3001\u8a73\u3057\u3044\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u308f\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3002<br>\u7dda\u866b\u306b\u306f\u3001\u4f53\u304c\u900f\u660e\u3067\u795e\u7d4c\u5185\u90e8\u3092\u7c21\u5358\u306b\u89b3\u5bdf\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3001\u5bff\u547d\u304c\u77ed\u304f\u8001\u5316\u306e\u904e\u7a0b\u3092\u6570\u65e5\u3067\u8abf\u3079\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3001\u3068\u3044\u3046\u4ed6\u306e\u751f\u304d\u7269\u306b\u306f\u306a\u3044\u5229\u70b9\u304c\u3042\u308a\u307e\u3059\u3002\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u7406\u89e3\u306b\u304a\u3044\u3066\u3001\u7dda\u866b\u3092\u7528\u3044\u305f\u7814\u7a76\u304c\u3053\u308c\u304b\u3089\u3082\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u3053\u3068\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<p><strong>\u53c2\u8003\u8cc7\u6599<\/strong><br>1\uff09Zbinden\u3089\u8457\u3000\u300cPhase Separation and Neurodegenerative Diseases: A Disturbance in the Force\u300d\u30012020\u5e74\u3000Developmental Cell, 55(1): 45-68\u3001doi: 10.1016\/j.devcel.2020.09.014<br>2\uff09\u767d\u6728\u8ce2\u592a\u90ce\u8457\u3000\u300c\u76f8\u5206\u96e2\u751f\u7269\u5b66\u300d\u30012019\u5e74\u3000\u6771\u4eac\u5316\u5b66\u540c\u4eba<\/p>\n\n\n\n<p><strong>\u76e3\u4fee\u8005<\/strong><br>\u65b0\u6d77\u967d\u4e00<br>1983\u5e74\u798f\u5ca1\u770c\u751f\u307e\u308c\u3002\u4e5d\u5dde\u5927\u5b66\u5927\u5b66\u9662\u7406\u5b66\u5e9c\u535a\u58eb\u8ab2\u7a0b\u4fee\u4e86\u3002\u88fd\u85ac\u4f01\u696d\u3067\u306e\u52e4\u52d9\u7d4c\u9a13\u3092\u7d4c\u3066\u3001\u73fe\u5728\u3001\u7523\u696d\u6280\u8853\u7dcf\u5408\u7814\u7a76\u6240\u30fb\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u9577\u3068\u3057\u3066\u300c\u6db2-\u6db2\u76f8\u5206\u96e2\u306b\u7740\u76ee\u3057\u305f\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u5236\u5fa1\u30fb\u65e9\u671f\u8a3a\u65ad\u300d\u306e\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p><strong>\u7814\u7a76\u5ba4HP<\/strong><br><a href=\"https:\/\/staff.aist.go.jp\/yoichi-shinkai\/\">https:\/\/staff.aist.go.jp\/yoichi-shinkai\/<\/a><\/p>\n\n\n\n<p class=\"has-text-align-right has-small-font-size\">\u00a92026 \u866b\u306e\u96c6\u3044\uff08\u7dda\u866b\u7814\u7a76\u8005\u30b3\u30df\u30e5\u30cb\u30c6\u30a3\uff09\u300c5.\u3000\u7dda\u866b\u3067\u795e\u7d4c\u306e\u75c5\u6c17\u3092\u8abf\u3079\u308b\u300d<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">CC BY<\/a><\/p>\n\n\n\n<p class=\"has-text-align-right\"><a href=\"#toc_container\">\u76ee\u6b21\u30da\u30fc\u30b8\u3078\u2191<\/a><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div><\/section>\n\n\n\n<section id=\"section-6\" class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h3 class=\"wp-block-heading\">6.\u3000\u5207\u65ad\u3055\u308c\u305f\u795e\u7d4c\u304c\u518d\u751f\u3059\u308b\u4ed5\u7d44\u307f\u3092\u7dda\u866b\u3067\u63a2\u308b<\/h3>\n\n\n\n<p>\u3000\u30d2\u30c8\u306e\u304b\u3089\u3060\u306b\u306f\u3001\u795e\u7d4c\u3068\u3088\u3070\u308c\u308b\u9577\u3044\u7e4a\u7dad\u304c\u9685\u3005\u307e\u3067\u8d70\u3063\u3066\u304a\u308a\u3001\u305d\u308c\u304c\u8133\u304b\u3089\u306e\u300c\u7b4b\u8089\u3092\u52d5\u304b\u305b\u300d\u3068\u3044\u3046\u6307\u4ee4\u3092\u9001\u3063\u305f\u308a\u3001\u71b1\u3044\u30fb\u51b7\u305f\u3044\u30fb\u75db\u3044\u306a\u3069\u306e\u611f\u899a\u4fe1\u53f7\u3092\u8133\u306b\u9001\u3063\u305f\u308a\u3059\u308b\u50cd\u304d\u3092\u3057\u3066\u3044\u307e\u3059\u3002\u3068\u3053\u308d\u304c\u3001\u30b1\u30ac\u306a\u3069\u3067\u795e\u7d4c\u7e4a\u7dad\u304c\u5207\u65ad\u3055\u308c\u3066\u3057\u307e\u3046\u3068\u3001\u305d\u308c\u304c\u3067\u304d\u306a\u304f\u306a\u308a\u307e\u3059\u3002\u305d\u306e\u7d50\u679c\u3001\u4f53\u3092\u52d5\u304b\u305d\u3046\u3068\u3057\u3066\u3082\u52d5\u304b\u306a\u3044\uff08\u904b\u52d5\u969c\u5bb3\uff09\u3001\u71b1\u3044\u30fb\u51b7\u305f\u3044\u30fb\u75db\u3044\u306a\u3069\u306e\u611f\u899a\u304c\u611f\u3058\u3089\u308c\u306a\u3044\uff08\u611f\u899a\u969c\u5bb3\uff09\u306a\u3069\u306e\u969c\u5bb3\u304c\u751f\u3058\u307e\u3059\u3002\u795e\u7d4c\u5207\u65ad\u306b\u3088\u308b\u969c\u5bb3\u3068\u3057\u3066\u6700\u3082\u4e00\u822c\u7684\u306b\u77e5\u3089\u308c\u3066\u3044\u308b\u306e\u306f\u810a\u9ac4\u640d\u50b7\u3067\u3059\u3002\u810a\u9ac4\u306f\u795e\u7d4c\u306e\u675f\u304c\u901a\u3063\u3066\u3044\u308b\u5834\u6240\u3067\u3001\u640d\u50b7\u306b\u3088\u308a\u795e\u7d4c\u7e4a\u7dad\u304c\u5207\u65ad\u3055\u308c\u308b\u3068\u3001\u640d\u50b7\u90e8\u4f4d\u3088\u308a\u4e0b\u306e\u611f\u899a\u304c\u5931\u308f\u308c\u3001\u52d5\u304b\u3059\u3053\u3068\u3082\u3067\u304d\u306a\u304f\u306a\u308a\u307e\u3059\u3002\u305d\u3057\u3066\u305d\u306e\u72b6\u6cc1\u306f\u307b\u3068\u3093\u3069\u6539\u5584\u3059\u308b\u3053\u3068\u306a\u304f\u4e00\u751f\u7d9a\u304f\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4e00\u65b9\u3001\u4f53\u306e\u90e8\u5206\u306b\u3088\u3063\u3066\u306f\u3001\u5207\u65ad\u3055\u308c\u305f\u795e\u7d4c\u304c\u518d\u751f\u3055\u308c\u308b\u3053\u3068\u3082\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u6307\u3092\u5b8c\u5168\u306b\u5207\u65ad\u3055\u308c\u305f\u5834\u5408\u3001\u75c5\u9662\u3067\u5207\u65ad\u3055\u308c\u305f\u6307\u3092\u3064\u306a\u3050\u624b\u8853\u3092\u884c\u3044\u307e\u3059\u3002\u305d\u306e\u6642\u306b\u9aa8\u3084\u8840\u7ba1\u3001\u8171\u306a\u3069\u3068\u5171\u306b\u201d\u795e\u7d4c\u3092\u3064\u306a\u3050\u201d\u624b\u8853\u3092\u884c\u3046\u3068\u3001\u3064\u306a\u3044\u3060\u76f4\u5f8c\u306f\u52d5\u304b\u306a\u304b\u3063\u305f\u6307\u304c\u3001\u6570\u30f6\u6708\u4ee5\u4e0a\u7d4c\u3064\u3068\u52d5\u304f\u3088\u3046\u306b\u306a\u308b\u3053\u3068\u304c\u3057\u3070\u3057\u3070\u3042\u308a\u307e\u3059\u3002\u624b\u8853\u3067\u306f\u795e\u7d4c\u7e4a\u7dad\u305d\u306e\u3082\u306e\u3067\u306f\u306a\u304f\u3001\u795e\u7d4c\u7e4a\u7dad\u304c\u5165\u3063\u3066\u3044\u308b\u7ba1\u3092\u3064\u306a\u3044\u3067\u3044\u308b\u306e\u3067\u3059\u304c\u3001\u624b\u8853\u5f8c\u6642\u9593\u304c\u7d4c\u3064\u3068\u305d\u306e\u4e2d\u3092\u795e\u7d4c\u7e4a\u7dad\u304c\u4f38\u3073\u3066\u795e\u7d4c\u56de\u8def\u304c\u518d\u5f62\u6210\u3055\u308c\u308b\u3053\u3068\u3067\u3001\u52d5\u304f\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002\u3053\u308c\u3092\u795e\u7d4c\u518d\u751f\u3068\u547c\u3073\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:60%\">\n<p>\u3000\u795e\u7d4c\u518d\u751f\u3092\u7d30\u80de\u30ec\u30d9\u30eb\u3067\u898b\u3066\u307f\u307e\u3057\u3087\u3046\uff08\u56f3\uff09\u3002\u795e\u7d4c\u306f\u795e\u7d4c\u7d30\u80de\u304b\u3089\u306a\u308a\u3001\u795e\u7d4c\u7d30\u80de\u306f\u8ef8\u7d22\u3068\u547c\u3070\u308c\u308b\u795e\u7d4c\u7e4a\u7dad\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u8ef8\u7d22\u3092\u5207\u65ad\u3059\u308b\u3068\u3001\u7d30\u80de\u4f53\u3068\u3064\u306a\u304c\u3063\u3066\u3044\u308b\u5074\u306e\u8ef8\u7d22\u306f\u9000\u7e2e\u3057\u3066\u5148\u7aef\u306b\u4e38\u3044\u69cb\u9020\u304c\u3067\u304d\u3001\u3064\u306a\u304c\u3063\u3066\u3044\u306a\u3044\u5074\u306e\u8ef8\u7d22\u306f\u6d88\u5931\u3057\u307e\u3059\u3002\u305d\u306e\u5f8c\u3001\u3057\u3070\u3089\u304f\u3059\u308b\u3068\u8ef8\u7d22\u5148\u7aef\u304c\u300c\u6210\u9577\u5186\u9310\u300d\u3068\u3044\u3046\u624b\u306e\u3088\u3046\u306a\u69cb\u9020\u306b\u5909\u5316\u3057\u3066\u3001\u305d\u308c\u304c\u524d\u9032\u3059\u308b\u3053\u3068\u3067\u8ef8\u7d22\u304c\u4f38\u3073\u3001\u6700\u7d42\u7684\u306b\u6a19\u7684\u306b\u518d\u7d50\u5408\u3057\u307e\u3059\u3002\u3053\u308c\u304c\u7d30\u80de\u30ec\u30d9\u30eb\u3067\u898b\u305f\u795e\u7d4c\u518d\u751f\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u795e\u7d4c\u518d\u751f\u306f\u304b\u3089\u3060\u306e\u3044\u308d\u3044\u308d\u306a\u90e8\u5206\u3067\u8d77\u304d\u307e\u3059\u304c\u3001\u8133\u3084\u810a\u9ac4\u306a\u3069\u306e\u4e2d\u67a2\u795e\u7d4c\u3067\u306f\u8d77\u304d\u307e\u305b\u3093\u3002\u4e2d\u67a2\u795e\u7d4c\u3067\u795e\u7d4c\u518d\u751f\u304c\u8d77\u304d\u306a\u3044\u306e\u306f\u3001\u4e2d\u67a2\u795e\u7d4c\u3092\u640d\u50b7\u3057\u3066\u3082\u4ed6\u306e\u795e\u7d4c\u3067\u8d77\u3053\u308b\u3088\u3046\u306a\u518d\u751f\u304c\u59cb\u307e\u3089\u306a\u3044\u304b\u3089\u306a\u306e\u3067\u3059\u304c\u3001\u305d\u306e\u9055\u3044\u306e\u539f\u56e0\u3092\u77e5\u308b\u305f\u3081\u306b\u306f\u795e\u7d4c\u518d\u751f\u306e\u3057\u304f\u307f\u3092\u307e\u305a\u7406\u89e3\u3059\u308b\u3053\u3068\u304c\u5fc5\u8981\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u54fa\u4e73\u52d5\u7269\u3092\u7528\u3044\u305f\u7814\u7a76\u3067\u306f1\u56de\u306e\u5b9f\u9a13\u306b\u77ed\u304f\u3066\u3082\u6570\u9031\u9593\u3001\u9577\u3051\u308c\u3070\u5e74\u5358\u4f4d\u306e\u6642\u9593\u304c\u304b\u304b\u308b\u3068\u3044\u3046\u554f\u984c\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:40%\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"1127\" height=\"1267\" src=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-6.jpg\" alt=\"\" class=\"wp-image-558\" srcset=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-6.jpg 1127w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-6-267x300.jpg 267w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-6-911x1024.jpg 911w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-6-768x863.jpg 768w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-6-670x753.jpg 670w\" sizes=\"(max-width: 1127px) 100vw, 1127px\" \/><\/figure>\n<\/div><\/div>\n<\/div>\n\n\n\n<p>\u5b9f\u306f\u795e\u7d4c\u518d\u751f\u306f\u54fa\u4e73\u52d5\u7269\u3060\u3051\u3067\u306f\u306a\u304f\u3001\u7121\u810a\u690e\u52d5\u7269\u3082\u542b\u3081\u305f\u3055\u307e\u3056\u307e\u306a\u52d5\u7269\u3067\u666e\u904d\u7684\u306b\u8d77\u304d\u308b\u73fe\u8c61\u3067\u3042\u308b\u3053\u3068\u304c\u8fd1\u5e74\u308f\u304b\u3063\u3066\u304d\u3066\u3044\u307e\u3059\u3002\u30e2\u30c7\u30eb\u751f\u7269\u3067\u3042\u308b\u7dda\u866b\u3067\u3082\u3001\u795e\u7d4c\u7e4a\u7dad\u3092\u30ec\u30fc\u30b6\u30fc\u3067\u5207\u65ad\u3059\u308b\u3068\u3001\u6570\u6642\u9593\u4ee5\u5185\u306b\u518d\u751f\u304c\u958b\u59cb\u3057\u307e\u3059\u3002\u305d\u3053\u3067\u3001\u5b9f\u9a13\u304c\u5bb9\u6613\u3067\u518d\u751f\u3082\u65e9\u3044\u7dda\u866b\u3092\u7528\u3044\u3066\u795e\u7d4c\u518d\u751f\u306e\u3057\u304f\u307f\u3092\u89e3\u660e\u3059\u308b\u3068\u3044\u3046\u7814\u7a76\u304c\u4e16\u754c\u4e2d\u3067\u59cb\u307e\u308a\u3001\u3053\u308c\u307e\u3067\u306b\u3055\u307e\u3056\u307e\u306a\u907a\u4f1d\u5b50\u306e\u95a2\u4e0e\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u4e2d\u306e\u3044\u304f\u3064\u304b\u306f\u54fa\u4e73\u52d5\u7269\u3067\u3082\u540c\u69d8\u306b\u795e\u7d4c\u518d\u751f\u306b\u95a2\u308f\u3063\u3066\u3044\u308b\u3053\u3068\u304b\u3089\u3001\u7dda\u866b\u3092\u7528\u3044\u305f\u795e\u7d4c\u518d\u751f\u306e\u7814\u7a76\u304c\u3001\u30d2\u30c8\u306e\u795e\u7d4c\u518d\u751f\u6cbb\u7642\u306b\u3082\u5f79\u7acb\u3064\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u76e3\u4fee\u8005<\/strong><br>\u4e45\u672c\u3000\u76f4\u6bc5\uff08\u540d\u53e4\u5c4b\u5927\u5b66\u5927\u5b66\u9662\u7406\u5b66\u7814\u7a76\u79d1\uff09<\/p>\n\n\n\n<p class=\"has-text-align-right has-small-font-size\">\u00a92026 \u866b\u306e\u96c6\u3044\uff08\u7dda\u866b\u7814\u7a76\u8005\u30b3\u30df\u30e5\u30cb\u30c6\u30a3\uff09\u300c6.\u3000\u5207\u65ad\u3055\u308c\u305f\u795e\u7d4c\u304c\u518d\u751f\u3059\u308b\u4ed5\u7d44\u307f\u3092\u7dda\u866b\u3067\u63a2\u308b\u300d<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">CC BY<\/a><\/p>\n\n\n\n<p class=\"has-text-align-right\"><a href=\"#toc_container\">\u76ee\u6b21\u30da\u30fc\u30b8\u3078\u2191<\/a><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div><\/section>\n\n\n\n<section id=\"section-7\" class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h3 class=\"wp-block-heading\">7.\u3000\u611f\u67d3\u30e2\u30c7\u30eb\u3068\u3057\u3066\u306e\u7dda\u866b<\/h3>\n\n\n\n<h4 class=\"wp-block-heading has-text-align-left\">\u7d30\u83cc\u611f\u67d3\u30e2\u30c7\u30eb<\/h4>\n\n\n\n<p>\u3000\u7dda\u866b<em>C. elegans<\/em>\u306f\u3001\u591a\u69d8\u306a\u751f\u547d\u73fe\u8c61\u306e\u30e2\u30c7\u30eb\u751f\u7269\u3068\u3057\u3066\u7528\u3044\u3089\u308c\u3066\u304d\u305f\u304c\u3001\u611f\u67d3\u30e2\u30c7\u30eb\u3068\u3057\u3066\u7528\u3044\u3089\u308c\u305f\u306e\u306f\u3001\u7b46\u8005\u306e\u77e5\u308b\u9650\u308a\u3067\u306f1999\u5e74\u306b\u5831\u544a\u3055\u308c\u305f\u7dd1\u81bf\u83cc\u611f\u67d3\u306b\u95a2\u3059\u308b\u7814\u7a76\u304c\u521d\u3081\u3066\u3067\u3042\u308b (1-3)\u3002\u7dd1\u81bf\u83cc\u306f\u6c34\u56de\u308a\u306a\u3069\u306e\u74b0\u5883\u306b\u5e83\u304f\u5b58\u5728\u3059\u308b\u7d30\u83cc\u3067\u3042\u308a\u3001\u5065\u5eb7\u306a\u4eba\u306b\u5bfe\u3057\u3066\u306f\u3042\u307e\u308a\u75c5\u539f\u6027\u3092\u793a\u3055\u306a\u3044\u304c\u3001\u514d\u75ab\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3057\u305f\u4eba\u306a\u3069\u3078\u306e\u611f\u67d3\uff08\u65e5\u548c\u898b\u611f\u67d3\u3068\u3044\u3046\uff09\u306e\u539f\u56e0\u83cc\u3068\u3057\u3066\u554f\u984c\u306b\u306a\u308b\u3002\u7dd1\u81bf\u83cc\u3092\u4e0e\u3048\u308b\u3068\u3001\u901a\u5e38\u306e\u80b2\u6210\u30d7\u30ec\u30fc\u30c8\u4e0a\u3067\u306f\u6570\u65e5\u3067\u3001\u6761\u4ef6\u306b\u3088\u3063\u3066\u306f\u6570\u6642\u9593\u3067\u7dda\u866b\u306f\u6b7b\u306b\u81f3\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u305f(1,2)\u3002\u300c\u8178\u30c1\u30d5\u30b9\u306e\u30e1\u30a2\u30ea\u30fc\u300d\u306e\u3088\u3046\u306b\u3001\u7121\u75c7\u72b6\u306e\u5065\u5eb7\u4fdd\u83cc\u8005\u304c\u591a\u304f\u306e\u4eba\u306b\u77e5\u3089\u305a\u306b\u611f\u67d3\u3055\u305b\u308b\u4f8b\u3082\u3042\u308b\u30c1\u30d5\u30b9\u83cc\u306b\u95a2\u3059\u308b\u7814\u7a76\u3067\u306f\u3001\u30de\u30a6\u30b9\u3067\u306e\u75c5\u539f\u6027\u304c\u5f37\u3044\u30cd\u30ba\u30df\u30c1\u30d5\u30b9\u83cc\u304c\u305d\u306e\u30e2\u30c7\u30eb\u3068\u3057\u3066\u9577\u5e74\u7814\u7a76\u306b\u7528\u3044\u3089\u308c\u3066\u304d\u305f\u304c\u3001\u30cd\u30ba\u30df\u30c1\u30d5\u30b9\u83cc\u306f\u7dda\u866b\u306b\u3082\u81f4\u6b7b\u6027\u306e\u75c5\u539f\u6027\u3092\u767a\u63ee\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u305f (4)\u3002\u3061\u306a\u307f\u306b\u3001\u7dd1\u81bf\u83cc\u3084\u30c1\u30d5\u30b9\u83cc\u306f\u30b0\u30e9\u30e0\u9670\u6027\u83cc\uff08\u30b0\u30e9\u30e0\u9670\u6027\u83cc\u3068\u967d\u6027\u83cc\u306f\u7d30\u80de\u58c1\u306e\u69cb\u9020\u306a\u3069\u306e\u9055\u3044\u306b\u3088\u308a\u30b0\u30e9\u30e0\u67d3\u8272\u3068\u3044\u3046\u67d3\u8272\u6cd5\u3067\u67d3\u3081\u5206\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u308b\uff09\u306b\u5c5e\u3059\u308b\u304c\u3001\u30b0\u30e9\u30e0\u967d\u6027\u83cc\u3068\u3057\u3066\u306f\u3001\u8178\u7403\u83cc\u3001\u80ba\u708e\u7403\u83cc\u3001\u9ec4\u8272\u30d6\u30c9\u30a6\u7403\u83cc\u304c\u7dda\u866b\u306b\u5bfe\u3057\u3066\u81f4\u6b7b\u6027\u306e\u75c5\u539f\u6027\u3092\u767a\u63ee\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f (5)\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u771f\u83cc\u30fb\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u30e2\u30c7\u30eb<\/h4>\n\n\n\n<p>\u3000\u771f\u83cc\u611f\u67d3\u306b\u3064\u3044\u3066\u306f\u3001\u5e38\u5728\u83cc\u3068\u3057\u3066\u30d2\u30c8\u306e\u7c98\u819c\u3084\u76ae\u819a\u306b\u5b58\u5728\u3057\u3066\u304a\u308a\u3001\u3068\u304d\u306b\u81a3\u708e\u306a\u3069\u306e\u65e5\u548c\u898b\u611f\u67d3\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u30ab\u30f3\u30b8\u30c0\u306a\u3069\u306b\u95a2\u3059\u308b\u7814\u7a76\u304c\u3042\u308b\u3002\u30ab\u30f3\u30b8\u30c0\u5c5e\u771f\u83cc\u306f\u7dda\u866b\u306e\u8178\u7ba1\u5185\u306b\u84c4\u7a4d\u3057\u3001\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u3084\u83cc\u7cf8\u5f62\u6210\u306a\u3069\u306b\u3088\u308b\u81f4\u6b7b\u6027\u306e\u75c5\u539f\u6027\u3092\u767a\u63ee\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u305f (6)\u3002<\/p>\n\n\n\n<p>\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u7cfb\u3068\u3057\u3066\u306f\u30012005\u5e74\u306bFlock House virus (FHV)\u3068\u3044\u3046\u30a6\u30a4\u30eb\u30b9\u306e\u8907\u88fd\u30b2\u30ce\u30e0\u3092\u4f53\u5185\u3067\u4f5c\u308b\u7dda\u866b\u306e\u4f5c\u88fd\u304c\u5831\u544a\u3055\u308c\u305f\u3082\u306e\u306e\u3001\u30a6\u30a4\u30eb\u30b9\u7c92\u5b50\u304c\u4f5c\u3089\u308c\u308b\u306b\u306f\u81f3\u3089\u306a\u304b\u3063\u305f(7)\u3002\u7dda\u866b<em>C. elegans<\/em>\u306b\u611f\u67d3\u3059\u308b\u30a6\u30a4\u30eb\u30b9\u3068\u3057\u3066\u306f\u3001\u8178\u7ba1\u7d30\u80de\u306b\u611f\u67d3\u3057\u3001\u8178\u7ba1\u306e\u7570\u5e38\u3092\u5f15\u304d\u8d77\u3053\u3059Orsay virus\u306a\u3069\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b (8)\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" width=\"2480\" height=\"1395\" src=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-7.jpg\" alt=\"\" class=\"wp-image-566\" style=\"width:800px\" srcset=\"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-7.jpg 2480w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-7-300x169.jpg 300w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-7-1024x576.jpg 1024w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-7-768x432.jpg 768w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-7-1536x864.jpg 1536w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-7-2048x1152.jpg 2048w, https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-content\/uploads\/2025\/01\/4-7-670x377.jpg 670w\" sizes=\"(max-width: 2480px) 100vw, 2480px\" \/><\/figure>\n<\/div>\n\n\n<h4 class=\"wp-block-heading has-text-align-left\">\u7dda\u866b\u306e\u6709\u7528\u6027\u3068\u3053\u308c\u304b\u3089\u306e\u5c55\u671b<\/h4>\n\n\n\n<p>\u3000\u3053\u306e\u3088\u3046\u306b\u3001\u7dda\u866b\u306f\u3055\u307e\u3056\u307e\u306a\u75c5\u539f\u4f53\u306e\u611f\u67d3\u30e2\u30c7\u30eb\u3068\u3057\u3066\u7528\u3044\u3089\u308c\u3066\u3044\u308b\u3002\u7dd1\u81bf\u83cc\u611f\u67d3\u5fdc\u7b54\u306a\u3069\u306b\u95a2\u308f\u308bMAPK\u7d4c\u8def\u306f\u9ad8\u7b49\u52d5\u7269\uff08\u54fa\u4e73\u985e\uff09\u306b\u304a\u3044\u3066\u3082\u514d\u75ab\u5fdc\u7b54\uff08\u708e\u75c7\u5fdc\u7b54\uff09\u306b\u95a2\u308f\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u7dda\u866b\u3092\u30e2\u30c7\u30eb\u3068\u3057\u3066\u75c5\u539f\u4f53\u306b\u5bfe\u3059\u308b\u5fdc\u7b54\u3092\u8abf\u3079\u308b\u3053\u3068\u306e\u6709\u7528\u6027\u306f\u9ad8\u3044\u3068\u8003\u3048\u3089\u308c\u308b\u3002\u75c5\u539f\u4f53\u611f\u67d3\u306e\u4e88\u9632\u3084\u6cbb\u7642\u306b\u3064\u306a\u304c\u308b\u3088\u3046\u3001\u7dda\u866b\u3092\u7528\u3044\u305f\u611f\u67d3\u30e2\u30c7\u30eb\u306e\u3055\u3089\u306a\u308b\u6d3b\u7528\u3092\u671f\u5f85\u3057\u305f\u3044\u3002<\/p>\n\n\n\n<p><strong>\u53c2\u8003\u8cc7\u6599<\/strong><br>1\uff09\u4e2d\u53f0\uff08\u9e7f\u6bdb\uff09\u679d\u91cc\u5b50\u3001\u7dda\u866b\u3092\u5229\u7528\u3057\u305f\u8178\u5185\u7d30\u83cc\u7814\u7a76\u30012023\u5e74 \u8178\u5185\u7d30\u83cc\u5b66\u96d1\u8a8c\u300138:9-19<br>2\uff09Mahajan-Miklos S, Tan MW, Rahme LG, Ausubel FM. Molecular mechanisms of bacterial virulence elucidated using a Pseudomonas aeruginosa-Caenorhabditis elegans pathogenesis model. 1999\u5e74 Cell. 96:47-56.<br>3\uff09Tan MW, Mahajan-Miklos S, Ausubel FM. Killing of Caenorhabditis elegans by Pseudomonas aeruginosa used to model mammalian bacterial pathogenesis. 1999\u5e74\u3000Proc Natl Acad Sci U S A. 96:715-720.<br>4\uff09Aballay A, Yorgey P, Ausubel FM. Salmonella typhimurium proliferates and establishes a persistent infection in the intestine of Caenorhabditis elegans. 2000\u5e74\u3000Curr Biol. 10:1539-542.<br>5\uff09Garsin DA, Sifri CD, Mylonakis E, Qin X, Singh KV, Murray BE, Calderwood SB, Ausubel FM. A simple model host for identifying Gram-positive virulence factors. 2001\u5e74\u3000Proc Natl Acad Sci U S A. 98:10892-897.<br>6\uff09Breger J, Fuchs BB, Aperis G, Moy TI, Ausubel FM, Mylonakis E. Antifungal chemical compounds identified using a C. elegans pathogenicity assay. 2007\u5e74\u3000PLoS Pathog. 3:e18.<br>7\uff09Lu R, Maduro M, Li F, Li HW, Broitman-Maduro G, Li WX, Ding SW. Animal virus replication and RNAi-mediated antiviral silencing in Caenorhabditis elegans, 2005\u5e74\u3000Nature. 436:1040-1043.<br>8\uff09Felix MA, Ashe A, Piffaretti J, Wu G, Nuez I, Belicard T, Jiang Y, Zhao G, Franz CJ, Goldstein LD, Sanroman M, Miska EA, Wang D. Natural and experimental infection of Caenorhabditis nematodes by novel viruses related to nodaviruses, 2011\u5e74\u3000PLoS Biol. 9:e1000586.<\/p>\n\n\n\n<p><strong>\u76e3\u4fee\u8005<\/strong><br>\u4e2d\u53f0\uff08\u9e7f\u6bdb\uff09\u679d\u91cc\u5b50<br>1977\u5e74\u4e5d\u5dde\u751f\u307e\u308c\u3002\u6771\u4eac\u5927\u5b66\u5927\u5b66\u9662\u535a\u58eb\u8ab2\u7a0b\u4fee\u4e86\u3002\u6771\u4eac\u5973\u5b50\u533b\u5927\u3001\u5927\u962a\u516c\u7acb\u5927\u306a\u3069\u3092\u7d4c\u3066\u3001\u73fe\u5728\u3001\u4eac\u90fd\u5927\u5b66\u6559\u6388\u3068\u3057\u3066\u300c\u8001\u5316\u3084\u611f\u67d3\u306e\u4ed5\u7d44\u307f\u300d\u306e\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p><strong>\u7814\u7a76\u5ba4HP<\/strong><br><a href=\"https:\/\/www.kagenakadailab.com\" data-type=\"link\" data-id=\"https:\/\/www.kagenakadailab.com\">https:\/\/www.kagenakadailab.com<\/a><\/p>\n\n\n\n<p class=\"has-text-align-right has-small-font-size\">\u00a92026 \u866b\u306e\u96c6\u3044\uff08\u7dda\u866b\u7814\u7a76\u8005\u30b3\u30df\u30e5\u30cb\u30c6\u30a3\uff09\u300c7.\u3000\u611f\u67d3\u30e2\u30c7\u30eb\u3068\u3057\u3066\u306e\u7dda\u866b\u300d<a href=\"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\">CC BY NC<\/a><\/p>\n\n\n\n<p class=\"has-text-align-right\"><a href=\"#toc_container\">\u76ee\u6b21\u30da\u30fc\u30b8\u3078\u2191<\/a><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div><\/section>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u76ee\u6b21 Illustrated by Hiroko Uchida&nbsp; \u7dda\u866b\u306f\u3001\u8001\u5316\u3001\u75be\u60a3\u3001\u640d\u50b7 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":666,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-676","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-json\/wp\/v2\/pages\/676","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-json\/wp\/v2\/comments?post=676"}],"version-history":[{"count":6,"href":"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-json\/wp\/v2\/pages\/676\/revisions"}],"predecessor-version":[{"id":1340,"href":"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-json\/wp\/v2\/pages\/676\/revisions\/1340"}],"up":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-json\/wp\/v2\/pages\/666"}],"wp:attachment":[{"href":"https:\/\/plaza.umin.ac.jp\/wormjp\/wordpress\/wp-json\/wp\/v2\/media?parent=676"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}