{"id":9980,"date":"2017-09-23T11:17:41","date_gmt":"2017-09-23T02:17:41","guid":{"rendered":"http:\/\/plaza.umin.ac.jp\/sawamura\/?p=9980"},"modified":"2022-05-30T12:51:22","modified_gmt":"2022-05-30T03:51:22","slug":"gliomamoleculardiag","status":"publish","type":"post","link":"https:\/\/plaza.umin.ac.jp\/sawamura\/glioma\/gliomamoleculardiag\/","title":{"rendered":"\u81e8\u5e8a\u533b\u306e\u305f\u3081\u306e\u5206\u304b\u308a\u3084\u3059\u3044\u30b0\u30ea\u30aa\u30fc\u30de\u907a\u4f1d\u5b50\u8a3a\u65ad"},"content":{"rendered":"<ul>\n<li>\u3053\u308c\u3067\u3082\u304b\u306a\u308a\u5358\u7d14\u5316\u3057\u305f\u3082\u306e\u3067\u3059<\/li>\n<li>\u6b63\u5f0f\u306b\u306f\uff0c2021\u5e74HWO\u5206\u985e\u3067\u3059<\/li>\n<li>\u4e00\u822c\u75c5\u9662\u3067\u3082\u3067\u304d\u308b\u514d\u75ab\u7d44\u7e54\u67d3\u8272\u3067\u3059<\/li>\n<li>\u5fc5\u8981\u306a\u306e\u306f\uff0c<span style=\"color: #000080;\"><strong>IDH1-R132H, nuclear ATRX, H3-K27M\uff0cH3.3 G34<\/strong><\/span>\u306b\u5bfe\u3059\u308b\u6297\u4f53\u3067\u3059<\/li>\n<li>\u305f\u3060\u3057\uff0c\u7b2c1\u67d3\u8272\u4f53\u77ed\u8155\u3068\u7b2c19\u67d3\u8272\u4f53\u9577\u8155\u306e\u6b20\u5931(<span style=\"color: #000080;\"><strong>1p\/19q loss<\/strong><\/span>)\u306f\uff0cFISH\u3067\u67d3\u8272\u4f53\u3092\u898b\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093<\/li>\n<li><strong><span style=\"color: #000080;\">\u307e\u305aIDH\u306e\u5909\u7570\u3092\u307f<\/span>\u308b<\/strong>\u3068\u3053\u308d\u304b\u3089\u30b9\u30bf\u30fc\u30c8\u3057\u307e\u3059\uff0c\u305d\u308c\u304b\u3089<span style=\"color: #000080;\"><strong>ATRX\u3092\u307f\u307e\u3059<\/strong><\/span><\/li>\n<li>IDH wild-type\u306e\u5834\u5408\u306f\uff0cIDH DNA\u30b7\u30fc\u30af\u30bb\u30f3\u30b9\u304c\u5fc5\u8981\u3068\u306a\u308a\u307e\u3059<\/li>\n<\/ul>\n<hr \/>\n<h5>\u6ce8\u610f<\/h5>\n<ul>\n<li>molecular diagnosis\u304c\u5ba2\u89b3\u7684\u3067\u6b63\u3057\u3044\u3068\u306f\u601d\u3044\u8fbc\u307e\u306a\u3044\u65b9\u304c\u3044\u3044\u3067\u3059<\/li>\n<li>\u514d\u75ab\u7d44\u7e54\u67d3\u8272\uff0cFISH\uff0cPCR\u89e3\u6790\u3067\u3082\u5206\u5b50\u8a3a\u65ad\u304c\uff0c\u898b\u305f\u76ee\u306e\u7d44\u7e54\u8a3a\u65ad\u3088\u308a\u6b63\u3057\u3044\u3068\u306f\u9650\u308a\u307e\u305b\u3093\uff0c\u3042\u304f\u307e\u3067\u3082\u7d44\u7e54\u8a3a\u65ad\u3068\u306e\u6574\u5408\u6027\u304c\u3042\u3063\u3066\u306e\u8a3a\u65ad\u3067\u3059<\/li>\n<li>\u907a\u4f1d\u5b50\u8a3a\u65ad\u306e\u78ba\u5b9f\u6027\u304c\u6975\u3081\u3066\u9ad8\u3044\u5834\u5408\u306b\u306f\uff0c\u7d44\u7e54\u8a3a\u65ad\u3068\u77db\u76fe\u304c\u3042\u3063\u3066\u3082\u907a\u4f1d\u5b50\u8a3a\u65ad\u540d\u3092\u3068\u308a\u307e\u3059<\/li>\n<\/ul>\n<div>\n<h5>\u3073\u307e\u3093\u6027\u30b0\u30ea\u30aa\u30fc\u30de\u30002021\u5e74\u306e\u5206\u985e\u306f\uff16\u7a2e\u985e<\/h5>\n<\/div>\n<p>1. <span style=\"color: #000080;\"><strong>\u4e4f\u7a81\u8d77\u81a0\u816b\u30b0\u30ec\u30fc\u30c92\u304b3<\/strong><\/span><br \/>\nIDH mutant, nuclear ATRX retained, 1p\/19q codel<\/p>\n<p>2. <span style=\"color: #000080;\"><strong>\u661f\u7d30\u80de\u816b\u30b0\u30ec\u30fc\u30c92\u304b3<\/strong><\/span><br \/>\nIDH mutant, nuclear ATRX lost, CDKN2A\/B retained<\/p>\n<p>3. <span style=\"color: #000080;\"><strong>\u661f\u7d30\u80de\u816b\u30b0\u30ec\u30fc\u30c94 \u00a0IDH\u5909\u7570\u578b<\/strong><\/span><br \/>\nIDH mutant, nuclear ATRX lost, CDKN2A\/B homozygously deleted<\/p>\n<p>4. \u00a0<span style=\"color: #000080;\"><strong>\u81a0\u82bd\u816b<\/strong><\/span><br \/>\nIDH wild type, nuclear ATRX retained, typical histology or TERT, EGFR, +7\/-10<\/p>\n<p>5. <span style=\"color: #000080;\"><strong>\u3073\u307e\u3093\u6027\u534a\u7403\u6027\u30b0\u30ea\u30aa\u30fc\u30de<\/strong><\/span> \u30b0\u30ec\u30fc\u30c94 H3.3 G34\u5909\u7570\u578b<br \/>\nIDH wild type, nuclear ATRX lost, H3.3 G34 mutant, age&lt;50<\/p>\n<p>6. <strong><span style=\"color: #000080;\">\u3073\u307e\u3093\u6027\u6b63\u4e2d\u30b0\u30ea\u30aa\u30fc\u30de<\/span><\/strong> \u30b0\u30ec\u30fc\u30c94 \u00a0H3 K27M\u5909\u7570\u578b<br \/>\nIDH wild type, nuclear ATRX retained, H3 K27M mutant<\/p>\n<h4>\u753b\u50cf\u4e0a\u6b63\u4e2d\u306b\u3042\u308b\u3082\u306e midline location<\/h4>\n<p>\u3053\u306e\u30bf\u30a4\u30d7\u306f\u5fc5\u305aH3-K27M\u67d3\u8272\u3092\u884c\u3044\u307e\u3059\uff0c\u5909\u7570\u304c\u3042\u3063\u305f\u6642\u306b\u306f\uff0c<\/p>\n<h5><a title=\"\u3073\u307e\u3093\u6027\u6b63\u4e2d\u30b0\u30ea\u30aa\u30fc\u30de diffuse midline glioma\" href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/glioma\/diffusemidlineglioma\/\">H3-K27M\u5909\u7570\u306e\u3042\u308b\u3073\u307e\u3093\u6027\u6b63\u4e2d\u30b0\u30ea\u30aa\u30fc\u30de<\/a><\/h5>\n<p>&nbsp;<\/p>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2017\/09\/yagishirionko.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-9982\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2017\/09\/yagishirionko-300x225.jpg\" alt=\"\" width=\"300\" height=\"225\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2017\/09\/yagishirionko-300x225.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2017\/09\/yagishirionko-768x576.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2017\/09\/yagishirionko-550x413.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2017\/09\/yagishirionko.jpg 850w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><br \/>\n\u713c\u5c3b\u5cf6\u306e\u30aa\u30f3\u30b3\u306e\u6728\u307f\u305f\u3044\u306b\u8907\u96d1\u3067\u56f0\u3063\u305f\u3082\u306e\u3067\u3059<\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p>\u5f15\u7528\uff1a\u00a0Weller M, et al.: European Association for Neuro-Oncology (EANO) guideline on the diagnosis and treatment of adult astrocytic and oligodendroglial gliomas. Lancet Oncol 2017\uff08\u898b\u3084\u3059\u3044\u56f3\u304c\u539f\u8457\u306b\u306f\u3042\u308a\u307e\u3059\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3053\u308c\u3067\u3082\u304b\u306a\u308a\u5358\u7d14\u5316\u3057\u305f\u3082\u306e\u3067\u3059 \u6b63\u5f0f\u306b\u306f\uff0c2021\u5e74HWO\u5206\u985e\u3067\u3059 \u4e00\u822c\u75c5\u9662\u3067\u3082\u3067\u304d\u308b\u514d\u75ab\u7d44\u7e54\u67d3\u8272\u3067\u3059 \u5fc5\u8981\u306a\u306e\u306f\uff0cIDH1-R132H, nuclear ATRX, H3-K27M\uff0cH3.3 G34\u306b\u5bfe\u3059\u308b\u6297\u4f53\u3067\u3059  [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"class_list":["post-9980","post","type-post","status-publish","format-standard","hentry","category-glioma"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/9980","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/comments?post=9980"}],"version-history":[{"count":10,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/9980\/revisions"}],"predecessor-version":[{"id":19609,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/9980\/revisions\/19609"}],"wp:attachment":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/media?parent=9980"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/categories?post=9980"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/tags?post=9980"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}