{"id":97,"date":"2012-04-17T22:22:35","date_gmt":"2012-04-17T13:22:35","guid":{"rendered":"\/sawamura\/wp\/?p=97"},"modified":"2025-12-09T13:11:07","modified_gmt":"2025-12-09T04:11:07","slug":"hemangioblastoma","status":"publish","type":"post","link":"https:\/\/plaza.umin.ac.jp\/sawamura\/braintumors\/hemangioblastoma\/","title":{"rendered":"\u8840\u7ba1\u82bd\u816b hemangioblastoma\uff0c\u30d5\u30a9\u30f3\u30fb\u30d2\u30c3\u30da\u30eb\u30fb\u30ea\u30f3\u30c9\u30a6\u75c5 VHL"},"content":{"rendered":"<div class=\"setumei\">\n<h4><span style=\"color: #000080;\"><strong>\u3069\u3093\u306a\u75c5\u6c17\uff1f<\/strong><\/span><\/h4>\n<ul>\n<li>\u8133\u816b\u760d\u306e\u3046\u3061\u306e\u767a\u751f\u983b\u5ea6\u306f1.7\uff05\u3067\u73cd\u3057\u3044\u816b\u760d\u3067\u3059<\/li>\n<li>\u767a\u751f\u90e8\u4f4d\u306f\u5c0f\u8133\u304c\u4e3b\u3067\uff0c\u305f\u307e\u306b\u5ef6\u9ac4\u3084\u810a\u9ac4\u306b\u3082\u3067\u304d\u307e\u3059<\/li>\n<li>\u767a\u75c7\u5e74\u9f62\u306f10\uff5e50\u6b73\u4ee3\u3067\u3059\u304c\uff0c\u6210\u4eba\u306b\u591a\u3044\u816b\u760d\u3067\u3059<\/li>\n<li>\u305f\u3044\u3066\u3044\u306f\uff11\u3064\u3060\u3051\u5c0f\u8133\u306b\u3067\u304d\u307e\u3059<\/li>\n<li>\u30b0\u30ec\u30fc\u30c91\u306e\u826f\u6027\u816b\u760d\u3067\u3059<\/li>\n<li>\u5c0f\u8133\u3084\u810a\u9ac4\uff0c\u8133\u5e79\u90e8\u306e\u8840\u7ba1\u82bd\u816b\u306b\uff0c\u7db2\u819c\u306e\u8840\u7ba1\u82bd\u816b\uff0c\u814e\u56a2\u816b\u3084\u814e\u7d30\u80de\u764c\uff0c\u81b5\u56a2\u816b\uff0c\u526f\u777e\u4e38\u56a2\u816b\u306a\u3069\u306e\u3044\u304f\u3064\u304b\u304c\u5408\u4f75\u3059\u308c\u3070\u30d5\u30a9\u30f3\u30fb\u30d2\u30c3\u30da\u30eb\u30fb\u30ea\u30f3\u30c9\u30a6\u75c5\u3068\u547c\u3070\u308c\u308b\u907a\u4f1d\u6027\u75be\u60a3\u3067\u3059\u304c\uff0c\u3068\u3066\u3082\u3081\u305a\u3089\u3057\u3044\u3082\u306e\u3067\u3059<\/li>\n<li>\u30d5\u30a9\u30f3\u30fb\u30d2\u30c3\u30da\u30eb\u30fb\u30ea\u30f3\u30c9\u30a6\u75c5\u306f\u5c02\u9580\u5bb6\u306e\u9593\u3067\u306fVHL\u3068\u547c\u3070\u308c\u307e\u3059<\/li>\n<li>von Hippel-Lindau \u75c5\u306e\u307f\u306a\u3089\u305a\uff0c\u5b64\u767a\u6027\u306e\u8840\u7ba1\u82bd\u816b\u306e\u4e00\u90e8\u3082\uff0c\u7b2c\uff13\u67d3\u8272\u4f53\u4e0a\u306e von Hippel-Lindau \u816b\u760d\u6291\u5236\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306b\u3088\u3063\u3066\u751f\u3058\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059<\/li>\n<li>\u5c0f\u8133\u534a\u7403\u306b\u767a\u751f\u3057\u305f\u8840\u7ba1\u82bd\u816b\u306f\u56a2\u80de\uff08\u6c34\u305f\u307e\u308a\u307f\u305f\u3044\u306a\u888b\uff09\u3092\u5f62\u6210\u3057\u3084\u3059\u304f\uff0c\u305d\u306e\u969b\uff0c\u5b9f\u8cea\u6027\u306e\u816b\u760d\u90e8\u5206\u304c\u58c1\u5728\u7d50\u7bc0\uff08\u5c0f\u3055\u3044\u304b\u305f\u307e\u308a\uff09\u3092\u4f5c\u308a\u307e\u3059<\/li>\n<li>\u75c5\u7406\u7d44\u7e54\u5b66\u7684\u306b\u306f\uff0c\u6bdb\u7d30\u8840\u7ba1\u3068foamy stromal cell\u304b\u3089\u306a\u308b\u826f\u6027\u306e\u816b\u760d\u3067\u3059<\/li>\n<li><span style=\"color: #ff0000;\"><strong>2025\u5e74\u306b\u30d9\u30eb\u30ba\u30c6\u30a3\u30d5\u30a1\u30f3\u3068\u3044\u3046\u85ac\u5264\u304c\u8a8d\u53ef\u3055\u308c\u307e\u3057\u305f<\/strong><\/span><\/li>\n<li>\u30d9\u30eb\u30ba\u30c6\u30a3\u30d5\u30a1\u30f3\u306f\uff0cVHL\u95a2\u9023\u8840\u7ba1\u82bd\u816b\u3092\u5c0f\u3055\u304f\u3059\u308b\u52b9\u679c\u3092\u3082\u3063\u3066\u3044\u307e\u3059<\/li>\n<li>\uff18\u5272\u304f\u3089\u3044\u306eVHL\u8840\u7ba1\u82bd\u816b\u306b\u52b9\u679c\u304c\u3042\u308b\u3068\u671f\u5f85\u3055\u308c\u307e\u3059<\/li>\n<\/ul>\n<h4><span style=\"color: #000080;\"><strong>\u75c7\u72b6\u3068\u8a3a\u65ad\u306f\uff1f<\/strong><\/span><\/h4>\n<ul>\n<li>\u5c0f\u8133\u75c7\u72b6\uff08\u3075\u3089\u3064\u3044\u3066\u6b69\u304d\u306b\u304f\u3044\uff0c\u306f\u304d\u3051\uff0c\u3081\u307e\u3044\uff09\u3084\u773c\u632f\uff08\u773c\u304c\u7d30\u304b\u304f\u52d5\u304f\uff09\u3067\u75c5\u6c17\u304c\u660e\u3089\u304b\u306b\u306a\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3057\u3087\u3046<\/li>\n<li>\u5c0f\u8133\u304b\u3089\u51fa\u3066\u5927\u304d\u304f\u306a\u308b\u3068\u7b2c\uff14\u8133\u5ba4\u3092\u8a70\u3081\u3066\u3057\u307e\u3046\u306e\u3067\u8133\u306e\u4e2d\u306b\u6c34\uff08\u9ac4\u6db2\uff09\u304c\u305f\u307e\u308a\u307e\u3059<\/li>\n<li>\u7b2c\uff14\u8133\u5ba4\u3068\u306f\u9ac4\u6db2\u306e\u51fa\u53e3\u3067\u3001\u3053\u308c\u3092\u9589\u585e\u6027\u6c34\u982d\u75c7\u3068\u3044\u3044\u307e\u3059<\/li>\n<li>\u982d\u75db\uff0c\u5614\u5410\uff0c\u3046\u3063\u8840\u4e73\u982d\uff08\u773c\u306e\u7db2\u819c\u304c\u816b\u308c\u308b\uff09\u306a\u3069\u306e\u982d\u84cb\u5185\u5727\u4ea2\u9032\u75c7\u72b6\u3068\u3044\u3046\u306e\u304c\u6c34\u982d\u75c7\u306e\u75c7\u72b6\u3067\u3059<\/li>\n<li>\u8840\u6db2\u691c\u67fb\u3067\u8d64\u8840\u7403\u5897\u591a\u75c7\u3092\u5408\u4f75\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u304c\uff0c\u3053\u308c\u306f\u816b\u760d\u304c\u30a8\u30ea\u30b9\u30ed\u30dd\u30a8\u30c1\u30f3\u3068\u3044\u3046\u8840\u6db2\u3092\u5897\u3084\u3059\u56e0\u5b50\u3092\u4f5c\u308b\u305f\u3081\u3067\u3059<\/li>\n<li>MRI\u3067\u306f\uff0c\u306e\u3046\u80de\uff08\u888b\u306b\u6c34\u304c\u305f\u307e\u3063\u305f\u3088\u3046\u306a\u3082\u306e\uff09\u3092\u9ad8\u983b\u5ea6\u306b\u8a8d\u3081\u307e\u3059<\/li>\n<li>\u816b\u760d\u306e\u672c\u4f53\u306f\u9020\u5f71\u5264\u3067\u5897\u5f37\u52b9\u679c\u3092\u3046\u3051\u3066\u767d\u304f\u4e38\u304f\u6620\u308a\u307e\u3059<\/li>\n<li>\u816b\u760d\u306f\u305f\u3044\u3066\u3044\u4e38\u304f\u3066\u306f\u3063\u304d\u308a\u3057\u305f\u5f62\u306b\u307f\u3048\u307e\u3059<\/li>\n<li>\u8a3a\u65ad\u3067\u307e\u3061\u304c\u3048\u3084\u3059\u3044\u306e\u306f\uff0c\u5c0f\u8133\u661f\u7d30\u80de\u816b\u3084\u306e\u3046\u80de\u6027\u8ee2\u79fb\u6027\u816b\u760d\u3067\u3059<\/li>\n<li>\u690e\u9aa8\u52d5\u8108\u64ae\u5f71\u3067\u306f\uff0c\u8457\u660e\u306a\u816b\u760d\u6fc3\u67d3\u50cf\uff08\u8840\u7ba1\u304c\u3044\u3063\u3071\u3044\uff09\u304c\u307f\u3089\u308c\u3066\u78ba\u5b9a\u8a3a\u65ad\u304c\u53ef\u80fd\u3067\u3059<\/li>\n<li>\u8840\u7ba1\u306e\u56fa\u307e\u308a\u307f\u305f\u3044\u306a\u816b\u760d\u3067\u3059\u304b\u3089\u51fa\u8840\u3057\u3084\u3059\u3044\u3067\u3059<\/li>\n<\/ul>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblaky1-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-18213\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblaky1-1-289x300.jpg\" alt=\"\" width=\"289\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblaky1-1-289x300.jpg 289w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblaky1-1-550x572.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblaky1-1.jpg 709w\" sizes=\"auto, (max-width: 289px) 100vw, 289px\" \/><\/a><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblaky2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-18212\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblaky2-291x300.jpg\" alt=\"\" width=\"291\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblaky2-291x300.jpg 291w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblaky2-550x566.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblaky2.jpg 709w\" sizes=\"auto, (max-width: 291px) 100vw, 291px\" \/><\/a><\/p>\n<p>\u5de6\u5c0f\u8133\u306b\u3067\u304d\u305f\u5c0f\u3055\u306a \u306e\u3046\u80de\u6027\u8840\u7ba1\u82bd\u816b\u3067\u3059\u3002\u77e2\u5370\u306e\u5148\u306b\u3042\u308b\u5c0f\u3055\u306a\u584a\u3060\u3051\u304c\u816b\u760d\u3067\u5468\u56f2\u306f\u816b\u760d\u304b\u3089\u67d3\u307f\u51fa\u3057\u305f\u6db2\u4f53\u304c\u6e9c\u307e\u3063\u3066\u3044\u307e\u3059\uff08\u306e\u3046\u80de\u3068\u3044\u3044\u307e\u3059\uff09\u3002\u53f3\u5074\u306f\u8840\u7ba1\u64ae\u5f71\u3068MRI\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u753b\u50cf\u3067\uff0c\u816b\u760d\u306b\u52d5\u8108\u304c\u6d41\u5165\u3057\u3066\u3044\u308b\u306e\u304c\u898b\u3048\u307e\u3059\u3002<\/p>\n<h4><strong><span style=\"color: #000080;\">\u6cbb\u7642\u306f\uff1f<\/span><\/strong><\/h4>\n<ul>\n<li>\u624b\u8853\u3067\u5b8c\u5168\u306b\u3068\u3063\u3066\u3057\u307e\u3048\u3070\u5b8c\u6cbb\u3059\u308b\u826f\u6027\u306e\u816b\u760d\u3067\uff0c\u8ee2\u79fb\u306f\u3057\u307e\u305b\u3093<\/li>\n<li>\u5c0f\u3055\u3044\u3082\u306e\u306e\u624b\u8853\u306f\u7c21\u5358(^O^)<\/li>\n<li>\u5927\u304d\u306a\u306e\u3046\u80de\u304c\u3042\u3063\u3066\u3082\u624b\u8853\u3067\u58c1\u5728\u7d50\u7bc0\uff08\u56a2\u80de\u306e\u4e2d\u306e\u56fa\u307e\u308a\uff09\u3055\u3048\u3068\u3063\u3066\u3057\u307e\u3048\u3070\u6cbb\u308a\u307e\u3059<\/li>\n<li>\u624b\u8853\u3067\u3068\u308c\u308b\u3068\u6c34\u982d\u75c7\u3082\u6cbb\u308a\u307e\u3059\u3057\u3001\u5c0f\u8133\u75c7\u72b6\u3082\u6539\u5584\u3057\u3066\u5feb\u9069\u306b\u306a\u308b\u3053\u3068\u304c\u307b\u3068\u3093\u3069\u3067\u3059<\/li>\n<li>3 cm\u3092\u8d8a\u3048\u308b\u3088\u3046\u306a\u5927\u304d\u306a\u8840\u7ba1\u82bd\u816b\u306f\u307e\u305f\u5225\u306e\u75c5\u6c17\u3068\u8003\u3048\u305f\u65b9\u304c\u3044\u3044\u307b\u3069\u5371\u967a\u306a\u3082\u306e\u306b\u306a\u308a\u307e\u3059<\/li>\n<li>\u5927\u304d\u306a\u3082\u306e\u3067\u306f\u624b\u8853\u3067\u5927\u91cf\u306e\u51fa\u8840\u304c\u3042\u308a\u307e\u3059\u3057\uff0c\u8133\u306e\u6b63\u5e38\u306a\u8840\u7ba1\u3068\u306f\u304c\u305b\u306a\u304f\u3066\u8133\u6897\u585e\u3092\u5408\u4f75\u3057\u3066\u3057\u307e\u3046\u3053\u3068\u3082\u3042\u308a\u307e\u3059<\/li>\n<li>\u3068\u304f\u306b\u8133\u5e79\u90e8\u306b\u304f\u3063\u3064\u3044\u305f\u5927\u304d\u306a\u8840\u7ba1\u82bd\u816b\u306e\u624b\u8853\u306f\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u306e\u3067\u3069\u3053\u3067\u624b\u8853\u3092\u53d7\u3051\u308b\u304b\u3092\u307b\u3093\u3068\u306b\u614e\u91cd\u306b\u8003\u3048\u3066\u4e0b\u3055\u3044<\/li>\n<li>\u5ef6\u9ac4\u3084\u810a\u9ac4\u306b\u6f5c\u308a\u8fbc\u3093\u3067\u3044\u3066\u3082\u53d6\u308c\u306a\u3044\u3068\u3044\u3046\u308f\u3051\u3067\u306f\u306a\u304f\u3066\uff0c\u5c0f\u3055\u3044\u3082\u306e\u306a\u3089\u624b\u8853\u306f\u3046\u307e\u304f\u884c\u304d\u307e\u3059<\/li>\n<li>\u3053\u308c\u3089\u3092\u624b\u8853\u3059\u308b\u5834\u5408\u306f\u8133\u5e79\u90e8\u8840\u7ba1\u816b\u306e\u305f\u304f\u3055\u3093\u306e\u624b\u8853\u7d4c\u9a13\u304c\u3042\u308b\u8133\u5916\u79d1\u533b\u3092\u635c\u3057\u305f\u65b9\u304c\u3044\u3044\u3067\u3059<\/li>\n<li>\u653e\u5c04\u7dda\u5916\u79d1\uff08\u30ac\u30f3\u30de\u30ca\u30a4\u30d5\u3084\u30ea\u30cb\u30a2\u30c3\u30af\uff09\u3067\u6cbb\u7642\u3059\u308b\u3053\u3068\u3082\u3067\u304d\u307e\u3059<\/li>\n<li>\u8fba\u7e01\u7dda\u91cf\u306715-20\u30b0\u30ec\u30a4\u304f\u3089\u3044\u3092\u304b\u3051\u307e\u3059<\/li>\n<li>\u653e\u5c04\u7dda\u5916\u79d1\u3067\u6cbb\u7642\u3092\u3057\u3066\u3082\u6b8b\u5ff5\u306a\u304c\u3089\u816b\u760d\u304c\u6d88\u3048\u308b\u3053\u3068\u306f\u3042\u308a\u307e\u305b\u3093<\/li>\n<li>\u816b\u760d\u304c\u7e2e\u3093\u3060\u308a\u5927\u304d\u304f\u306a\u3089\u306a\u3044\u78ba\u7387\u304c70-85%\u304f\u3089\u3044\u3068\u601d\u308f\u308c\u307e\u3059<\/li>\n<li>\uff12\u5272\u524d\u5f8c\u3067\u653e\u5c04\u7dda\u306b\u3088\u308b\u6d6e\u816b\u304c\u8d77\u3053\u308a\u307e\u3059\u304c\uff0c\u3053\u308c\u304c\u5ef6\u9ac4\u3084\u810a\u9ac4\u306b\u8d77\u3053\u308b\u3068\u610f\u5916\u306b\u9577\u5f15\u3044\u3066\u91cd\u3044\u5f8c\u907a\u75c7\u3092\u751f\u3058\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059<\/li>\n<li>\u653e\u5c04\u7dda\u5916\u79d1\u6cbb\u7642\u306f\u624b\u8853\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3068\u601d\u308f\u308c\u308b\u6642\u306b\u8003\u3048\u307e\u3059\u304c\uff0c\u305d\u306e\u3088\u3046\u306a\u816b\u760d\u3067\u306f\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u526f\u4f5c\u7528\u306e\u30ea\u30b9\u30af\u3082\u540c\u3058\u3088\u3046\u306b\u9ad8\u3044\u306e\u3067\u614e\u91cd\u306b\u8003\u3048\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093<\/li>\n<li>\u5206\u5272\u7167\u5c04\u306f\u526f\u4f5c\u7528\u304c\u5c11\u306a\u3044\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u304c\uff0c\u306f\u3063\u304d\u308a\u3057\u305f\u6cbb\u7642\u52b9\u679c\u306f\u5224\u3063\u3066\u3044\u307e\u305b\u3093<\/li>\n<li>\u307e\u305a\u624b\u8853\u6458\u51fa\u3092\u512a\u5148\u7684\u306b\u8003\u3048\u305f\u65b9\u304c\u3044\u3044\u3067\u3057\u3087\u3046<\/li>\n<\/ul>\n<hr \/>\n<h3><span style=\"color: #000080;\">\u8840\u7ba1\u82bd\u816b\u306e\u624b\u8853\u306e\u96e3\u3057\u3055\u306b\u306f\u75c7\u4f8b\u306b\u3088\u3063\u3066\u5929\u3068\u5730\u306e\u958b\u304d\u304c\u3042\u308a\u307e\u3059<\/span><\/h3>\n<div class=\"Wrapper clearFix\">\n<h4><span style=\"color: #000080;\"><strong>\u7c21\u5358\u306a\u624b\u8853\u3068\u306a\u308b\u4f8b<\/strong><\/span><\/h4>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangiocystic1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-4449\" title=\"hemangiocystic\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangiocystic1-290x300.jpg\" alt=\"\" width=\"290\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangiocystic1-290x300.jpg 290w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangiocystic1-550x567.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangiocystic1.jpg 698w\" sizes=\"auto, (max-width: 290px) 100vw, 290px\" \/><\/a>\u00a0<a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemang1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-full wp-image-4450\" title=\"hemang1\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemang1.jpg\" alt=\"\" width=\"284\" height=\"284\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemang1.jpg 284w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemang1-200x200.jpg 200w\" sizes=\"auto, (max-width: 284px) 100vw, 284px\" \/><\/a><\/p>\n<p>\u5de6\u53f3\u306e\u5199\u771f\u306f\u7570\u306a\u3063\u305f\u60a3\u8005\u3055\u3093\u306e\u3082\u306e\u3067\u3059\u3002\u4e21\u8005\u3068\u3082\u306b\uff0c\u5927\u304d\u306a\u56a2\u80de\uff08\u6c34\u305f\u307e\u308a\uff09\u3092\u4f34\u3046\u5c0f\u8133\u5185\u90e8\u306e\u5c0f\u3055\u306a\u8840\u7ba1\u82bd\u816b\u3067\u3059\u3002\u53f3\u306e\u65b9\u306b\u5c0f\u3055\u304f\u767d\u3044\u584a\uff08\u9ec4\u8272\u306e\u77e2\u5370\uff09\u304c\u898b\u3048\u308b\u306e\u3067\u3059\u304c\uff0c\u305d\u308c\u3060\u3051\u304c\u816b\u760d\u3067\uff0c\u6fc3\u3044\u7070\u8272\u306b\u898b\u3048\u308b\u90e8\u5206\u306f\u306e\u3046\u80de\u3068\u3044\u3063\u3066\u6db2\u4f53\u304c\u305f\u307e\u3063\u3066\u3044\u308b\u3060\u3051\u3067\u3059\u3002<br \/>\n\u3053\u308c\u306f\u3068\u3066\u3082\uff08\u3068\u3044\u3063\u3066\u306f\u4f55\u3067\u3059\u304c\u6bd4\u8f03\u7684\u306b\uff09\u7c21\u5358\u306a\u624b\u8853\u4f8b\u3067\u3059\u3002\u5c0f\u8133\u5931\u8abf\u306b\u3088\u308b\u3075\u3089\u3064\u304d\u3084\u6c34\u982d\u75c7\u3088\u308b\u982d\u75db\u3068\u5614\u5410\u306a\u3069\u3092\u51fa\u3057\u307e\u3059\u304c\uff0c\u624b\u8853\u5f8c\u306b\u75c7\u72b6\u306f\u6539\u5584\u3057\u307e\u3059\u3002<br \/>\n\u4e00\u822c\u306b\u5c0f\u8133\u534a\u7403\u3068\u3044\u3046\u5834\u6240\u306b\u3067\u304d\u305f\u3082\u306e\u306f\u5927\u304d\u304f\u3066\u3082\u624b\u8853\u306e\u6210\u529f\u7387\u306f\u3068\u3066\u3082\u9ad8\u3044\u3067\u3059\u3002\u5c0f\u3055\u3044\u3082\u306e\u3067\u306f\u5834\u6240\u3068\u75c7\u72b6\u306b\u3088\u3063\u3066\u306f\u30ac\u30f3\u30de\u30ca\u30a4\u30d5\u306a\u3069\u306e\u653e\u5c04\u7dda\u6cbb\u7642\u3082\u6709\u52b9\u306a\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u3057\u304b\u3057\uff0c\u624b\u8853\u3067\u6458\u51fa\u3067\u304d\u308b\u3082\u306e\u306f\u6458\u51fa\u3057\u305f\u65b9\u304c\u78ba\u5b9f\u306b\u6cbb\u308a\u307e\u3059\u3002<\/p>\n<h4><strong><span style=\"color: #000080;\">\u3082\u306e\u3059\u3054\u304f\u96e3\u3057\u3044\u8840\u7ba1\u82bd\u816b<\/span><\/strong><\/h4>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemang21.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-7355\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemang21-200x200.png\" alt=\"hemang2\" width=\"200\" height=\"200\" \/><\/a><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemang3.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-7356\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemang3-200x200.png\" alt=\"hemang3\" width=\"200\" height=\"200\" \/><\/a><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemang4.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-7357\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemang4-200x200.png\" alt=\"hemang4\" width=\"200\" height=\"200\" \/><\/a><\/p>\n<p>\u3053\u308c\u3082\u8840\u7ba1\u82bd\u816b\u3067\u3059\u3002\u304a\u305d\u3089\u304f\u5c0f\u8133\u767a\u751f\u306a\u306e\u3067\u3057\u3087\u3046\u304c\uff0c\u5ef6\u9ac4\u306e\u4e21\u5074\u306b\u5f37\u304f\u7652\u7740\u3057\u3066\u3044\u3066\u5ef6\u9ac4\u306e\u8840\u7ba1\u3082\u816b\u760d\u306e\u4e2d\u306b\u5165\u3063\u3066\u3044\u3066\uff0c\u816b\u760d\u8840\u7ba1\u306b\u306f\u52d5\u8108\u7624\u3082\u5408\u4f75\u3057\u3066\u3044\u3066\u7834\u88c2\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u816b\u760d\u3092\u6458\u51fa\u3059\u308b\u306e\u306f\u4e0d\u53ef\u80fd\u306b\u3082\u601d\u3048\u307e\u3057\u305f\u304c\uff0c\u7121\u4e8b\u306b\u3067\u304d\u307e\u3057\u305f\uff08\u4e0b\u306e\u5199\u771f\uff09\u3002\u60a3\u8005\u3055\u3093\u3082\u79c1\u3082\u3078\u3068\u3078\u3068\u306b\u306a\u308a\u307e\u3057\u305f\u3002 \u3067\u3082\uff0c\u3053\u306e\u3088\u3046\u306a\u8840\u7ba1\u82bd\u816b\u306e\u624b\u8853\u306f\u3046\u307e\u304f\u884c\u304f\u3068\u306f\u9650\u308a\u307e\u305b\u3093\uff0c\u624b\u8853\u4e0d\u53ef\u80fd\u3068\u8003\u3048\u305f\u65b9\u304c\u3044\u3044\u304b\u3082\u3057\u308c\u306a\u3044\u3068\u4eca\u3067\u3082\u601d\u3063\u3066\u3044\u307e\u3059\u3002\u624b\u8853\u3059\u308b\u3068\u6c7a\u3081\u308c\u3070\u3082\u306e\u3059\u3054\u304f\u9ad8\u3044\u30ea\u30b9\u30af\u3092\u60a3\u8005\u3055\u3093\u3082\u5916\u79d1\u533b\u3082\u80cc\u8ca0\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u3057\u3066\u6cbb\u308b\u30b5\u30a4\u30ba\u3067\u306f\u306a\u3044\u306e\u3067\u4ed6\u306b\u6cbb\u7642\u6cd5\u306f\u3042\u308a\u307e\u305b\u3093\u304c (&gt;_&lt;) \u3000\u5927\u304d\u306a\u8840\u7ba1\u82bd\u816b\u3092\u624b\u8853\u3059\u308b\u63d0\u6848\u3092\u3055\u308c\u305f\u3089\uff0c\u5c11\u306a\u304f\u3068\u3082\u57f7\u5200\u533b\u306e\u7d4c\u9a13\u6570\u306f\u5c0b\u306d\u307e\u3057\u3087\u3046\u3002<\/p>\n<\/div>\n<\/div>\n<hr \/>\n<h3><span style=\"color: #000080;\">\u30d5\u30a9\u30f3\u30fb\u30d2\u30c3\u30da\u30eb\u30fb\u30ea\u30f3\u30c9\u30a6\u75c5 VHL von Hippel Lindau disease<\/span><\/h3>\n<ul>\n<li>\u907a\u4f1d\u6027\u306e\u75c5\u6c17\u3067\u3059<\/li>\n<li>\u8133\u3068\u810a\u9ac4\u306e\u8840\u7ba1\u82bd\u816b\u304c\u591a\u767a\u3057\u305f\u3068\u304d\u306bVHL\u3068\u3044\u3044\u307e\u3059<\/li>\n<li>\u814e\u81d3\u30ac\u30f3 clear cell renal cell carcinoma\uff0c\u8910\u8272\u7d30\u80de\u816b\uff0c\u81b5\u81d3\u306e\u795e\u7d4c\u5185\u5206\u6ccc\u816b\u760d\uff0c\u7cbe\u5de3\u4e0a\u4f53\u56a2\u80de\u817a\u816b\uff0c\u5074\u982d\u9aa8\u5185\u306e\u5185\u30ea\u30f3\u30d1\u56a2\u816b\u760d endolymphatic sac tumor\u306a\u3069\u304c\u5408\u4f75\u3057\u307e\u3059<\/li>\n<li><span style=\"color: #000080;\"><strong>\u7db2\u819c\u306e\u8840\u7ba1\u82bd\u816b\uff0c\u814e\u56a2\u816b\uff0c\u814e\u7d30\u80de\u764c<\/strong><\/span>\u306a\u3069\u3082\u542b\u3081\u3066\u73fe\u5728\u3067\u306f<span style=\"color: #000080;\"><strong>\u3044\u308d\u3044\u308d\u5b89\u5168\u306a\u6cbb\u7642\u624b\u6bb5\u304c\u3042\u308a\u307e\u3059<\/strong><\/span><\/li>\n<li>\u6cbb\u7642\u306e\u5f8c\u907a\u75c7\u5c11\u306a\u304f\u66ae\u3089\u3059\u306b\u306f<strong><span style=\"color: #ff0000;\">\u5c0f\u8133\u3068\u5ef6\u9ac4\u810a\u9ac4\u306e\u8840\u7ba1\u82bd\u816b\u306e\u6cbb\u7642\u304c\u3082\u3063\u3068\u3082\u5927\u5207<\/span><\/strong>\u3067\u3059<\/li>\n<li>VHL\u3067\u306f\u8907\u6570\u306e\u8840\u7ba1\u82bd\u816b\u304c\u5c0f\u8133\u3084\u810a\u9ac4\u306b\u3067\u304d\u307e\u3059\u306e\u3067\uff0c\u624b\u8853\u3092\u4f55\u56de\u304b\u53d7\u3051\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3053\u3068\u3082\u3042\u308a\u307e\u3059<\/li>\n<li>\u3069\u306e\u816b\u760d\u3092\u6458\u51fa\u3057\u3066\u3069\u306e\u816b\u760d\u3092\u305d\u306e\u307e\u307e\u306b\u3057\u3066\u304a\u304f\u304b\u306e\u5224\u65ad\u306f\u96e3\u3057\u3044\u3067\u3059<\/li>\n<li>\u75c7\u72b6\u3082\u306a\u304f\u3066\u5076\u7136\u767a\u898b\u3055\u308c\u305f\u5c0f\u3055\u3044\u8840\u7ba1\u82bd\u816b\u306f\u69d8\u5b50\u3092\u898b\u308b\u3060\u3051\u3067\u3044\u3044\u3067\u3059<\/li>\n<li>\u5de8\u5927\u306a\u3082\u306e\u306f\u3068\u3093\u3067\u3082\u306a\u304f\u96e3\u3057\u3044\u306e\u3067\uff0c\u30d5\u30a9\u30f3\u30fb\u30d2\u30c3\u30da\u30eb\u30fb\u30ea\u30f3\u30c9\u30a6\u75c5\u306e\u53ef\u80fd\u6027\u306e\u3042\u308b\u5b50\u4f9b\u305f\u3061\u306f\u75c7\u72b6\u304c\u306a\u304f\u3066\u3082\u65e9\u3081\u306bMRI\u691c\u67fb\u3092\u53d7\u3051\u308b\u3088\u3046\u306b\u304a\u52e7\u3081\u3057\u307e\u3059<\/li>\n<li>\u691c\u67fb\u3092\u305f\u3081\u3089\u3063\u3066\u816b\u760d\u3092\u5de8\u5927\u306b\u3057\u3066\u306f\u306a\u308a\u307e\u305b\u3093<\/li>\n<\/ul>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangio5.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-full wp-image-7444\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangio5.png\" alt=\"hemangio5\" width=\"218\" height=\"274\" \/><\/a>\u30d5\u30a9\u30f3\u30fb\u30d2\u30c3\u30da\u30eb\u30fb\u30ea\u30f3\u30c9\u30a6\u75c5\u306e\u60a3\u8005\u3055\u3093\u306e\u810a\u9ac4\uff08\u80f8\u9ac4\uff09\u306b\u3067\u304d\u305f\u8840\u7ba1\u82bd\u816b\u3067\u3059\u3002\u4e0a\u4e0b\u306e\u810a\u9ac4\u304c\u816b\u308c\u305f\u308a\uff0c\u810a\u9ac4\u306e\u4e2d\u306b\u7a7a\u6d1e\uff08\u816b\u760d\u306e\u3046\u80de\u3042\u308b\u3044\u306f\u810a\u9ac4\u7a7a\u6d1e\u75c7\u3068\u3044\u3044\u307e\u3059\uff09\u304c\u3067\u304d\u307e\u3059\u3002 \u624b\u8853\u6cbb\u7642\u306f\u75c7\u72b6\u304c\u51fa\u308b\u307e\u3067\uff0c\u3042\u308b\u3044\u306f\u75c7\u72b6\u304c\u304b\u306a\u308a\u5f37\u304f\u306a\u3063\u3066\u304b\u3089\u3057\u304b\u3057\u307e\u305b\u3093\u3002\u306a\u305c\u306a\u3089\uff0c\u305f\u304f\u3055\u3093\u3067\u304d\u308b\uff08\u591a\u767a\uff09\u3059\u308b\u3053\u3068\u304c\u591a\u304f\u3066\uff0c\u8907\u6570\u56de\u306e\u624b\u8853\u306b\u306a\u3063\u3066\u3057\u307e\u3046\u3053\u3068\u3082\u3042\u308b\u304b\u3089\u3067\u3059\u3002\u624b\u8853\u3092\u3059\u308b\u305f\u3073\u306b\uff0c\u56db\u80a2\u306e\u3057\u3073\u308c\u3084\u9ebb\u75fa\u306a\u3069\u306e\u5f8c\u907a\u75c7\u304c\u306e\u3053\u308b\u53ef\u80fd\u6027\u3082\u3042\u308b\u306e\u3067\uff0c\u3053\u306e\u624b\u8853\u306f\uff0c\u810a\u9ac4\u816b\u760d\u306e\u624b\u8853\u7d4c\u9a13\u304c\u76f8\u5f53\u306b\u305f\u304f\u3055\u3093\u3042\u308b\u8133\u5916\u79d1\u533b\u306b\u3057\u304b\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n<h5>\u30d5\u30a9\u30f3\u30fb\u30d2\u30c3\u30da\u30eb\u30fb\u30ea\u30f3\u30c9\u30a6\u75c5 VHL \u306e\u8840\u7ba1\u82bd\u816b\u304c\u5927\u304d\u304f\u306a\u308b\u304b\u3069\u3046\u304b<\/h5>\n<p>Ammerman JM, et al.: Long-term natural history of hemangioblastomas in patients with von Hippel\u2013Lindau disease: implications for treatment. J Neurosurg 105: 248-255, 2006 10\u5e74\u4ee5\u4e0a\u7d4c\u904e\u3092\u898b\u305f19\u4eba\u306eVHL\u306e\u60a3\u8005\u3055\u3093\u3067143\u500b\u306e\u8840\u7ba1\u82bd\u816b\u304c\u8ffd\u8de1\u3055\u308c\u307e\u3057\u305f\u3002138\u500b\u3067\u816b\u760d\u5897\u5927\u3057\u307e\u3057\u305f\u304c\u75c7\u5019\u6027\u3068\u306a\u3063\u305f\u3082\u306e\u306f58\u500b\u3067\u3057\u305f\u3002\u7279\u306b\u6ce8\u610f\u3057\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3053\u3068\u306f\uff0c<strong><span style=\"color: #ff0000;\">\u8840\u7ba1\u82bd\u816b\u304cstuttering patten\u3068\u3044\u3046\u5897\u5927\u50be\u5411\u3092\u3068\u308b<\/span><\/strong>\u3053\u3068\u3067\u3059\u3002step-wise growth\u3068\u3082\u3044\u308f\u308c\u307e\u3059\u3002\u8981\u3059\u308b\u306b\uff0c\u5927\u304d\u304f\u306a\u3063\u3066\u3082\u307e\u305f\u5897\u5927\u50be\u5411\u304c\u505c\u6b62\u3059\u308b\u3068\u3044\u3046\u73cd\u3057\u3044\u50be\u5411\u304c\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002 \u5e73\u5747\u5897\u5927\u671f growht period \u304c13\u30f6\u6708\u3067\uff0c\u5e73\u5747\u9759\u6b62\u671f quiescent period \u304c25\u30f6\u6708\u3068\u66f8\u304b\u308c\u3066\u3044\u307e\u3059\u300215\u304b\u6708\u5897\u5927\u3057\u3066\u305d\u306e\u5f8c\u306b25\u30f6\u6708\u5927\u304d\u304f\u306a\u3089\u306a\u3044\u3067\u9759\u6b62\u3059\u308b\u3068\u3044\u3046\u610f\u5473\u3067\u3059\u3002\u306e\u3046\u80de\u6027\u8840\u7ba1\u82bd\u816b\u306e\u5897\u5927\u901f\u5ea6\u3068\u75c7\u5019\u6027\u3068\u306a\u308b\u78ba\u7387\u306f\u9ad8\u3044\u3068\u66f8\u304b\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u810a\u9ac4\u8840\u7ba1\u82bd\u816b\u3067\u306f22mm3\u4ee5\u4e0a\u306e\u3082\u306e\u3067\u75c7\u5019\u6027\u3068\u306a\u308b\u78ba\u7387\u304c\u9ad8\u3044\u3068\u306e\u7d50\u679c\u3067\u3059\u3002<\/p>\n<h5><span style=\"color: #000080;\">\u30d5\u30a9\u30f3\u30fb\u30d2\u30c3\u30da\u30eb\u30fb\u30ea\u30f3\u30c9\u30a6\u75c5\u3068\u8840\u7ba1\u82bd\u816b\u306e\u767a\u751f<\/span><\/h5>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangiooo2.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-7359\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangiooo2-200x200.png\" alt=\"hemangiooo2\" width=\"200\" height=\"200\" \/><\/a><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioo1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-7360\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioo1-200x200.png\" alt=\"hemangioo1\" width=\"200\" height=\"200\" \/><\/a><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioo3.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-7361\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioo3-200x200.png\" alt=\"hemangioo3\" width=\"200\" height=\"200\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioo3-200x200.png 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioo3-300x300.png 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioo3.png 452w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/a><\/p>\n<p>\u30d5\u30a9\u30f3\u30d2\u30c3\u30da\u30eb\u30ea\u30f3\u30c9\u30a6\u75c5\u306b\u5408\u4f75\u3057\u305f\u5927\u304d\u306a\u53f3\u5c0f\u8133\u534a\u7403\u8840\u7ba1\u82bd\u816b\u3067\u3059\u3002\u5927\u304d\u306a\u3082\u306e\u3067\u306f\u9759\u8108\u74b0\u6d41\u969c\u5bb3(\u9b31\u6ede)\u306e\u305f\u3081\u306b\u8133\u6d6e\u816b\u3092\u6765\u3059\u3053\u3068\u304c\u591a\u3044\u3057\uff0c\u305d\u306e\u5206\uff0c\u624b\u8853\u6642\u306e\u9759\u8108\u5727\u304c\u9ad8\u304f\u3066\u6b62\u8840\u304c\u96e3\u3057\u3044\u3068\u8003\u3048\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093\u3002\u6c34\u982d\u75c7\u3092\u5448\u3057\u3066\u75c7\u72b6\u306f\u91cd\u7be4\u3067\u3057\u305f\u304c\uff0c\u53f3\u5f8c\u982d\u7aa9\u958b\u982d\u3067\u6bd4\u8f03\u7684\u7c21\u5358\u306b\u5168\u6458\u51fa\u3067\u304d\u3066\u56de\u5fa9\u3057\u307e\u3057\u305f\u3002\u5c0f\u8133\u534a\u7403\u306b\u751f\u3058\u308b\u3082\u306e\u306f\u624b\u8853\u3067\u5927\u304d\u306a\u969c\u5bb3\u3092\u6b8b\u3059\u3053\u3068\u306f\u307b\u3068\u3093\u3069\u306a\u304f\u8853\u5f8c\u306e\u75c7\u72b6\u75c7\u72b6\u306e\u56de\u5fa9\u3082\u9806\u8abf\u306a\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u3002<\/p>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangiooo6.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-7362\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangiooo6-200x200.png\" alt=\"hemangiooo6\" width=\"200\" height=\"200\" \/><\/a><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangiooo5.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-7363\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangiooo5-200x200.png\" alt=\"hemangiooo5\" width=\"200\" height=\"200\" \/><\/a><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangiooo7.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-7364\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangiooo7-200x200.png\" alt=\"hemangiooo7\" width=\"200\" height=\"200\" \/><\/a><\/p>\n<p>\u540c\u3058\u60a3\u8005\u3055\u3093\u3067\u3059\u3002\u4e0a\u8a18\u306e\u624b\u8853\u306e5\u5e74\u5f8c\u306b\u65b0\u305f\u306a\u8840\u7ba1\u82bd\u816b\u304c\u6fc0\u3057\u304f\u5897\u5927\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u5c0f\u8133\u866b\u90e8\u306a\u306e\u3067\u4e21\u5074\u306e\u4e0a\u5c0f\u8133\u52d5\u8108\u304cfeeding artery\u3068\u306a\u308a\u307e\u3059\u3002bilateral occipital transtentorial approach\u3068\u3044\u3046\u7279\u6b8a\u306a\u624b\u8853\u65b9\u6cd5\u3067\u3057\u304b\u6458\u51fa\u3067\u304d\u307e\u305b\u3093\u3002\u5e78\u3044\u3053\u306e\u816b\u760d\u3082\u7121\u4e8b\u306b\u5168\u6458\u51fa\u3067\u304d\u307e\u3057\u305f\u3002<br \/>\nVHL\u306e\u60a3\u8005\u3055\u3093\u306f\u3053\u3046\u306a\u308b\u524d\u306b\u3082\u3046\u5c11\u3057\u983b\u56de\u306b\u8133\u306eMRI\u3092\u3057\u3066\u614e\u91cd\u306b\u7d4c\u904e\u89b3\u5bdf\u3092\u3057\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093\u3002\u5c11\u306a\u304f\u3068\u30822\u5e74\u306b\u4e00\u5ea6\u306eMRI\u306f\u5fc5\u8981\u3067\u3059\u3002\u9006\u306b\uff0cstuttering pattern\u304c\u3042\u308a\uff0c\u5897\u5927\u50be\u5411\u3092\u793a\u3057\u3066\u3082\u5897\u5927\u505c\u6b62\u3059\u308b\u3053\u3068\u304c\u3042\u308b\u306e\u3067\uff0c\u624b\u8853\u3059\u308b\u304b\u3069\u3046\u304b\u306e\u5224\u65ad\u306f\u983b\u56de\u306bMRI\u3092\u3057\u3066\u614e\u91cd\u306b\u3057\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093\u3002VHL\u306e\u60a3\u8005\u3055\u3093\u306f\u3068\u3066\u3082\u591a\u6570\u56de\u306e\u624b\u8853\u3092\u53d7\u3051\u308b\u306e\u3067\u3069\u3046\u3057\u3066\u3082\u3057\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u6642\u3060\u3051\u624b\u8853\u6458\u51fa\u3092\u3057\u307e\u3059\u3002<\/p>\n<h5>VHL\u306e\u539f\u56e0<\/h5>\n<ul>\n<li>VHL\u816b\u760d\u6291\u5236\u907a\u4f1d\u5b50 <span style=\"color: #000080;\"><strong>VHL tumor suppressor gene<\/strong><\/span> \u306e\u5909\u7570\u304c\u751f\u3058\u307e\u3059<\/li>\n<li>\u3059\u308b\u3068\u7d44\u7e54\u5185\u306e<strong><span style=\"color: #000080;\">HIF<\/span><\/strong> (hypoxia inducible factor)\u304c\u5897\u52a0\u3057\u307e\u3059<\/li>\n<li>\u4f4e\u9178\u7d20\u72b6\u614b\u3067\u306e\u8840\u6db2\u4f9b\u7d66\u3092\u4fc3\u3059\u4f5c\u7528\u306e\u3042\u308b<span style=\"color: #000080;\"><strong>HIF-2\u03b1 transcription factor<\/strong><\/span> \u306f\u8840\u7ba1\u5897\u6b96\u56e0\u5b50\u306e\u7523\u751f\u3092\u8a98\u5c0e\u3059\u308b\u306e\u3067<\/li>\n<li><span style=\"color: #000080;\"><strong>VEGF<\/strong><\/span>\u00a0(vascular endothelial growth factor)\uff0c<strong><span style=\"color: #000080;\">PDGF<\/span><\/strong>(platelet-derived growth factor),\u00a0<span style=\"color: #000080;\"><strong>TGF-\u03b1<\/strong><\/span> (transforming growth factor), <strong><span style=\"color: #000080;\">EP<\/span><\/strong> (erythropoetin) \u306e\u904e\u5270\u767a\u73fe\u3092\u6765\u3057\u307e\u3059<\/li>\n<li>\u3053\u308c\u3089\u306e\u56e0\u5b50\u304c\u8840\u7ba1\u5185\u76ae\u306e\u816b\u760d\u6027\u7570\u5e38\u5897\u6b96\u3092\u62db\u304f\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059<\/li>\n<li>\u3053\u306e\u904e\u7a0b\u3092\u6291\u3048\u3066\u6cbb\u7642\u3092\u3059\u308b\u305f\u3081\u306b\uff0c<span style=\"color: #000080;\"><strong>HIF-2\u03b1\u963b\u5bb3\u5264<\/strong><\/span>\u304c\u958b\u767a\u3055\u308c\u3066\u304d\u3066\u3044\u307e\u3059<\/li>\n<\/ul>\n<h4>\u816b\u760d\u968f\u4f34\u75c7\u5019\u7fa4\uff1a\u30a8\u30ea\u30b9\u30ed\u30dd\u30a8\u30c1\u30f3\u7523\u751f\u306b\u3088\u308b<span style=\"color: #000080;\"><strong>\u591a\u8840\u75c7<\/strong><\/span><\/h4>\n<p>\u5c0f\u8133\uff0c\u8133\u5e79\u90e8\uff0c\u810a\u9ac4\u8840\u7ba1\u82bd\u816b\u306f\uff0c\u9020\u8840\u56e0\u5b50\u3067\u3042\u308b\u30a8\u30ea\u30b9\u30ed\u30dd\u30a8\u30c1\u30f3 erythropietin\u3092\u7523\u751f\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u30a8\u30ea\u30b9\u30ed\u30dd\u30a8\u30c1\u30f3\u306e\u4f5c\u7528\u3067\u8d64\u8840\u7403 RBC\u304c\u5897\u3048\u3066\uff0c\u591a\u8840\u75c7\u306b\u306a\u308a\u307e\u3059\u3002\u30d8\u30e2\u30b0\u30ed\u30d3\u30f3\u3068\u30d8\u30de\u30c8\u30af\u30ea\u30c3\u30c8\u306e\u5024\u3082\u4e0a\u6607\u3057\u3066\uff0c\u8840\u6db2\u304c\u6fc3\u304f\u306a\u308a\u307e\u3059\u3002\u7009\u8840\u304c\u5fc5\u8981\u3068\u306a\u308b\u5834\u5408\u3082\u3042\u308b\u304f\u3089\u3044\u3067\u3059\u3002<\/p>\n<h4>\u65b0\u3057\u3044\u6cbb\u7642\u85ac\u306e\u958b\u767a<\/h4>\n<ul>\n<li>\u814e\u81d3\u764c\u306b\u7528\u3044\u3089\u308c\u308b\uff0c\u30d9\u30d0\u30b7\u30ba\u30de\u30d6\u3084\u30d1\u30be\u30d1\u30cb\u30d6\u3068\u3044\u3046\u85ac\u5264\u3067\u816b\u760d\u304c\u7e2e\u5c0f\u3057\u305f\u3068\u3044\u3046\u5831\u544a\u306f\u3042\u308a\u307e\u3059\u304c\uff0c\u52b9\u679c\u306f\u9650\u5b9a\u7684\u3067\u3059<\/li>\n<li>HIF-2\u03b1\u306e\u4f5c\u7528\u3092\u6291\u5236\u3059\u308b\u7d4c\u53e3\u85ac\u304c\u7c73\u56fd\u3067\u8a8d\u53ef\u3055\u308c\u307e\u3057\u305f<\/li>\n<li>HIF2\u963b\u5bb3\u85ac\u306e\u6cbb\u9a13\u304c\u65e5\u672c\u3067\u3082\u958b\u59cb\u3055\u308c\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093<\/li>\n<\/ul>\n<h2><span style=\"color: #ff0000;\"><strong>\u30d9\u30eb\u30ba\u30c6\u30a3\u30d5\u30a1\u30f3 belzutifan<\/strong><\/span><\/h2>\n<p>HIF-2\u03b1\u963b\u5bb3\u5264\u3067\uff0c\u814e\u764c\u306b\u6709\u52b9\u6027\u304c\u8a3c\u660e\u3055\u308c\u5e02\u8ca9\u3055\u308c\u3066\u3044\u308b\u7d4c\u53e3\u6442\u53d6\u306e\u85ac\u5264\u3067\u3059\u3002\u7c73\u56fd\u3067\u306f2021\u4eba\u306b\u4e2d\u67a2\u795e\u7d4c\u306e\u8840\u7ba1\u82bd\u816b\u306b\u5bfe\u3057\u3066\u8a8d\u53ef\u3055\u308c\u307e\u3057\u305f\u3002\u534a\u6570\u307b\u3069\u306e\u60a3\u8005\u3055\u3093\u3067\u8840\u7ba1\u82bd\u816b\u306e\u7e2e\u5c0f\u304c\u307f\u3089\u308c\uff0c12\u30f6\u6708\u4ee5\u4e0a\u306f\u52b9\u679c\u304c\u3042\u308b\u3088\u3046\u3067\u3059\u3002\u816b\u760d\u5468\u56f2\u6d6e\u816b\u306e\u8efd\u6e1b\u3082\u5f97\u3089\u308c\u307e\u3059\u3002\u6709\u5bb3\u4e8b\u8c61\u306f\u9ad8\u5ea6\u306e\u8ca7\u8840\u3067\u3059\u30022023\u5e74\uff0c\u65e5\u672c\u3067\u306f\u307e\u3060\u4f7f\u7528\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n<h2>\u30d9\u30d0\u30b7\u30ba\u30de\u30d6\u5316\u5b66\u7642\u6cd5\u30fb\u85ac\u7269\u6cbb\u7642<\/h2>\n<p>\u6297VEGF\u6297\u4f53 \u30d9\u30d0\u30b7\u30ba\u30de\u30d6\u306f\uff0c2010\u5e74\u9803\u304b\u3089\u8133\u810a\u9ac4\u306e\u8840\u7ba1\u82bd\u816b\u306b\u7528\u3044\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u7a00\u306b\u4e00\u5b9a\u671f\u9593\u816b\u760d\u304c\u7e2e\u5c0f\u3057\u305f\u3068\u306e\u75c7\u4f8b\u5831\u544a\u306b\u6b62\u307e\u308a\u307e\u3059\u3002\u9ad8\u8840\u5727\u3084\u51fa\u8840\u304c\u526f\u4f5c\u7528\u3067\u3059\u3002<\/p>\n<h2>\u30d1\u30be\u30d1\u30cb\u30d6\u5316\u5b66\u7642\u6cd5\u30fb\u85ac\u7269\u6cbb\u7642<\/h2>\n<p>\u814e\u81d3\u304c\u3093\u306b\u4f7f\u7528\u3055\u308c\u308b\u30c1\u30ed\u30b7\u30f3\u30fb\u30ad\u30ca\u30fc\u30bc\u963b\u5bb3\u5264\u3000\u30d0\u30be\u30d1\u30cb\u30d6\uff08\u30f4\u30a7\u30c8\u30ea\u30a8\u30f3\u30c8\uff09\u306f\uff0cVEGFR, PDGFR\u306a\u3069\u8840\u7ba1\u65b0\u751f\u306b\u95a2\u308f\u308b\u30ea\u30bb\u30d7\u30bf\u30fc\u306e\u50cd\u304d\u3092\u6291\u5236\u3057\u3066\uff0c\u8840\u7ba1\u6027\u816b\u760d\u306e\u5897\u6b96\u3092\u6291\u3048\u308b\u4f5c\u7528\u304c\u3042\u308a\u307e\u3059\u3002\u30d1\u30be\u30d1\u30cb\u30d6\u3092\u814e\u81d3\u304c\u3093\u306b\u4f7f\u7528\u3059\u308b\u3068\uff0c\u540c\u6642\u306b\uff0c\u5c0f\u8133\u3084\u810a\u9ac4\u306e\u8840\u7ba1\u82bd\u816b\u304c\u5c0f\u3055\u304f\u306a\u3063\u305f\u3068\u3044\u3046\u75c7\u4f8b\u5831\u544a\u304c2012\u5e74\u9803\u304b\u3089\u6563\u767a\u7684\u306b\u3042\u308a\u307e\u3059\u3002\u3057\u304b\u3057\uff0c\u52b9\u679c\u306f\u3068\u3066\u3082\u9650\u5b9a\u7684\u3067\u52b9\u304b\u306a\u3044\u3053\u3068\u3082\u591a\u3044\u3057\uff0c\u816b\u760d\u304c\u5c0f\u3055\u304f\u306a\u3063\u3066\u3082\u30d1\u30be\u30d1\u30cb\u30d6\u3092\u4e2d\u65ad\u3059\u308b\u3068\u307e\u305f\u5897\u5927\u3057\u307e\u3059\u3002\u526f\u4f5c\u7528\u306f\u8840\u6813\u75c7\u3067\u3059\u3002<\/p>\n<hr \/>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-8793 size-large\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/sudati-550x414.jpg\" alt=\"sudati\" width=\"550\" height=\"414\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/sudati-550x414.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/sudati-300x226.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/sudati-768x578.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/sudati.jpg 922w\" sizes=\"auto, (max-width: 550px) 100vw, 550px\" \/><\/p>\n<h4>\u8840\u7ba1\u82bd\u816b\u306f\u9ac4\u6db2\u64ad\u7a2e\u8ee2\u79fb\u3059\u308b\u304b\uff1f\u3000\u591a\u767a\u3068\u306e\u9055\u3044\u306f\uff1f<\/h4>\n<ul>\n<li>\u8840\u7ba1\u82bd\u816b\u306f\u3082\u306e\u3059\u3054\u304f\u7a00\u3067\u3059\u304c\uff0c<span style=\"color: #000080;\"><strong>\u9ac4\u6db2\u64ad\u7a2e\u3057\u307e\u3059<\/strong><\/span><\/li>\n<li>\u982d\u84cb\u5185\u3067\u5c0f\u8133\u5ef6\u9ac4\u4ee5\u5916\u306e\u90e8\u4f4d\u306b\u591a\u767a\u3057\u305f\u6642\u306b\u306f\u8003\u3048\u307e\u3059<\/li>\n<li>\u810a\u9ac4\u3060\u3068\u591a\u767a\u3068\u64ad\u7a2e\u306f\u533a\u5225\u3057\u3065\u3089\u3044\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u304c\uff0c\u8edf\u819c\u4e0a\u304b\u9ac4\u5185\u304b\u3067\u5224\u5225\u3057\u307e\u3059<\/li>\n<\/ul>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-18720\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblastomahst2-300x300.jpg\" alt=\"\" width=\"300\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblastomahst2-300x300.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblastomahst2-550x548.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblastomahst2-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblastomahst2-768x765.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblastomahst2.jpg 850w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-18719\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblastomahst21-300x292.jpg\" alt=\"\" width=\"300\" height=\"292\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblastomahst21-300x292.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblastomahst21-550x534.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblastomahst21-768x746.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblastomahst21.jpg 850w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblastomatsangio.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-18721\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblastomatsangio-300x296.jpg\" alt=\"\" width=\"300\" height=\"296\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblastomatsangio-300x296.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblastomatsangio-550x542.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblastomatsangio-768x757.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblastomatsangio.jpg 850w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblastomatspatho.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-18722\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblastomatspatho-300x293.jpg\" alt=\"\" width=\"300\" height=\"293\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblastomatspatho-300x293.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblastomatspatho-550x537.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblastomatspatho-768x750.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblastomatspatho.jpg 850w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>\u5c0f\u8133\u304b\u3089\u767a\u751f\u3057\u305f\u58ee\u5e74\u7537\u6027\u306e\u8840\u7ba1\u82bd\u816b\u3067\u3059\u3002\u8840\u7ba1\u64ae\u5f71\u3067\u3082\u75c5\u7406\u6240\u898b\u3067\u3082\u3054\u304f\u666e\u901a\u306eWHO\u30b0\u30ec\u30fc\u30c91\u306e\u8840\u7ba1\u82bd\u816b\u3067\u3059\u3002\u810a\u9ac4\uff0c\u814e\u81d3\uff0c\u81b5\u81d3\u306a\u3069\u306b\u816b\u760d\u306e\u5408\u4f75\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u5b8c\u5168\u6458\u51fa\u3057\u307e\u3057\u305f\u3002<\/p>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblastomahsgd1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-large wp-image-18723\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblastomahsgd1-257x600.jpg\" alt=\"\" width=\"257\" height=\"600\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblastomahsgd1-257x600.jpg 257w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblastomahsgd1-129x300.jpg 129w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblastomahsgd1.jpg 567w\" sizes=\"auto, (max-width: 257px) 100vw, 257px\" \/><\/a><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblastomahsgd2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-large wp-image-18724\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblastomahsgd2-291x600.jpg\" alt=\"\" width=\"291\" height=\"600\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblastomahsgd2-291x600.jpg 291w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblastomahsgd2-146x300.jpg 146w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/hemangioblastomahsgd2.jpg 567w\" sizes=\"auto, (max-width: 291px) 100vw, 291px\" \/><\/a><\/p>\n<p>\u6458\u51fa\u5f8c\uff15\u5e74\uff0c\u5de6\u4e0b\u80a2\u9055\u548c\u611f\u3067\u767a\u75c7\u3057\u307e\u3057\u305f\u3002\u810a\u9ac4\u8868\u9762\u306b\u7121\u6570\u306emass\u304c\u3042\u308a\uff0c\u810a\u9ac4\u8edf\u819c\u3082\u7dda\u72b6\u306b\u5897\u5f37\u3055\u308c\u307e\u3059\u3002\u9ac4\u6db2\u64ad\u7a2e\u306e\u6240\u898b\u3067\u3059\u3002\u3055\u3089\u306b\uff12\u5e74\u5f8c\uff08\u53f3\u306e\u753b\u50cf\uff09\u3067\u306f\u982d\u84cb\u5185\u306e\u8133\u69fd\u306b\u3082\u591a\u6570\u306e\u8ee2\u79fb\u3092\u751f\u3058\u307e\u3057\u305f\u3002\u9838\u9ac4\u9ac4\u5185\u306f\u8868\u9762\u306e\u3082\u306e\u304c\u6d78\u6f64\u3057\u305f\u3082\u306e\u3067\u3059\u3002\u3053\u306e\u4f8b\u306f\uff0c\u30d5\u30a9\u30f3\u30d2\u30c3\u30da\u30eb\u30ea\u30f3\u30c9\u30a6\u75c5\u306e\u591a\u767a\u8840\u7ba1\u82bd\u816b\u3067\u306f\u306a\u304f\uff0c\u9ac4\u6db2\u64ad\u7a2e\u8ee2\u79fb\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<h1 style=\"text-align: center;\"><a href=\"https:\/\/www.vhl-japan.org\">\u30d5\u30a9\u30f3<span style=\"color: #000080;\">\u30fb\u30d2\u30c3\u30da\u30eb\u30fb\u30ea\u30f3\u30c9\u30a6\u75c5\u306e\u60a3\u8005\u3055\u3093\u306e\u4f1a\u300c\u307b\u3063\u3068chain\u300d\uff08\u3053\u3053\u3092\u30af\u30ea\u30c3\u30af\uff09<\/span><\/a><\/h1>\n<hr \/>\n<h3 id=\"pathology\">\u7551\u4e2d\u4f73\u5948\u5b50\u306e\u75c5\u7406\u6559\u5ba4\uff1a\u8840\u7ba1\u82bd\u816b<\/h3>\n<h5><span style=\"color: #000080;\"><strong>\u5c0f\u8133\u75c7\u72b6\u3067\u767a\u75c7\u3057\u305f40\u4ee3\u7537\u6027\u306e\u75c7\u4f8b<\/strong><\/span><\/h5>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/07\/hemangiob\/hemangitera1.png\"><img loading=\"lazy\" decoding=\"async\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/07\/hemangiob\/hemangitera1.png\" alt=\"\" width=\"230\" height=\"242\" \/><\/a> <a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/07\/hemangiob\/hemangitera2.png\"><img loading=\"lazy\" decoding=\"async\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/07\/hemangiob\/hemangitera2.png\" alt=\"\" width=\"246\" height=\"246\" \/><\/a><\/p>\n<p>\u771f\u507d\u306e\u307b\u3069\u306f\u89e3\u308a\u307e\u305b\u3093\u304c\u982d\u306e\u4e2d\u3067\u8840\u6db2\u304c\u6d41\u308c\u308b\u97f3\u304c\u3059\u308b\u3068\u3044\u3046\u306e\u304c\u4e3b\u8a34\u3067\u3059\u3002\u305d\u306e\u5f8c\u306b\u8efd\u5ea6\u306e\u6b69\u884c\u5931\u8abf\u3068\u69cb\u8a9e\u969c\u5bb3\u304c\u51fa\u3066\u767a\u898b\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u7a0b\u5ea6\u306e\u3082\u306e\u3067\u3082AVM\u3068\u540c\u3058\u3088\u3046\u306b\u8840\u7ba1\u96d1\u97f3\u3092\u81ea\u899a\u3059\u308b\u3053\u3068\u304c\u3042\u308b\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u753b\u50cf\u3092\u3088\u304f\u898b\u308b\u3068\u53f3\u306e\u5c0f\u8133\u6241\u6843\u306e\u3082\u306e\u3067\uff0c\u5ef6\u9ac4\u306f\u305f\u3060\u5727\u8feb\u3055\u308c\u3066\u3044\u308b\u3060\u3051\u3067\u3059\u3002\u8840\u7ba1\u82bd\u816b\u306f\u30a8\u30ea\u30b9\u30ed\u30dd\u30a8\u30c1\u30f3\u3092\u7523\u751f\u3057\u3066\u591a\u8840\u75c7\u306b\u306a\u308b\u3053\u3068\u304c\u3042\u308b\u306e\u3067\u3059\u304c\uff0c\u3053\u306e\u60a3\u8005\u3055\u3093\u306f16.6 MIU\/ml\u3067\u6b63\u5e38\u5024\u3067\u3057\u305f\u3002<\/p>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/07\/hemangiob\/hemangitera4.png\"><img loading=\"lazy\" decoding=\"async\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/07\/hemangiob\/hemangitera4.png\" alt=\"\" width=\"234\" height=\"278\" \/><\/a> <a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/07\/hemangiob\/hemangitera5.png\"><img loading=\"lazy\" decoding=\"async\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/07\/hemangiob\/hemangitera5.png\" alt=\"\" width=\"232\" height=\"277\" \/><\/a><\/p>\n<p>\u53f3\u306ePICA\u304c\u4e3b\u305f\u308bfeeding artery\u3067\u3059\u3002\u3067\u3082PICA\u306eretromedullary segment\u304b\u3089short feeders\u304c\u6d41\u5165\u3057\u3066\u3044\u307e\u3059\u304b\u3089\uff0c\u6cb9\u65ad\u3092\u3059\u308b\u3068\u5ef6\u9ac4\u80cc\u5074\u969c\u5bb3\u3068\u3044\u3046\u53b3\u3057\u3044\u624b\u8853\u5408\u4f75\u75c7\u3092\u751f\u3058\u308b\u53ef\u80fd\u6027\u306f\u5341\u5206\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u816b\u760d\u306f\u6b63\u4e2d\u5f8c\u982d\u4e0b\u958b\u982d\u3067\u5168\u6458\u51fa\u3067\u304d\u307e\u3057\u305f\u3057\uff0c\u795e\u7d4c\u8131\u843d\u75c7\u72b6\u3092\u6b8b\u3057\u3066\u3044\u307e\u305b\u3093\u3002\u96e3\u6613\u5ea6\u306f\u4e2d\u7b49\u5ea6\u306e\u3082\u306e\u3067\u3059\u3002<\/p>\n<h4>\u4e0a\u8a18\u306e\u75c7\u4f8b\u306e\u75c5\u7406\u6240\u898b<\/h4>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/07\/hemangiob\/hemangihe3.png\"><img loading=\"lazy\" decoding=\"async\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/07\/hemangiob\/hemangihe3.png\" alt=\"\" width=\"398\" height=\"287\" \/><\/a><\/p>\n<p>\u5f31\u62e1\u3067\u306f\u591a\u6570\u306e\u8840\u7ba1\u304c\u816b\u760d\u306e\u4e2d\u306b\u898b\u3089\u308c\u308b\uff0c\u8d64\u8840\u7403\u3092\u542b\u3080\u5927\u5c0f\u306e\u8840\u7ba1\u8154\u3067\u69cb\u6210\u3055\u308c\u308b\u816b\u760d\u3067\u3042\u308b\u3002<\/p>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/07\/hemangiob\/hemangihe2.jpg\"><img loading=\"lazy\" decoding=\"async\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/07\/hemangiob\/hemangihe2.jpg\" alt=\"\" width=\"389\" height=\"316\" \/><\/a><\/p>\n<p>\u9593\u8cea\u306b\u5897\u6b96\u3059\u308b\u6de1\u6843\u8272\u306e\u80de\u4f53\u3084\u7a7a\u80de\u304c\u8c4a\u304b\u306astromal cells\uff0c\u3053\u306e\u90e8\u5206\u306fcellular variant\u3068\u547c\u3070\u308c\u308b\u3002stromal cell\u3067\u306f\uff0cVEGF\uff08\u8840\u7ba1\u5185\u76ae\u5897\u6b96\u56e0\u5b50\uff09\u3068VHL protein\uff08\u30d5\u30a9\u30f3\u30d2\u30c3\u30da\u30eb\u30ea\u30f3\u30c9\u30fc\u75c5\u95a2\u9023\u86cb\u767d\uff09\u304c\u67d3\u307e\u308b\u306e\u3067\uff0c\u3053\u306e\u816b\u760d\u7d30\u80de\u304c\u6fc0\u3057\u3044\u8840\u7ba1\u5897\u6b96\u3092\u4fc3\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002<\/p>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/07\/hemangiob\/hemangihe1.png\"><img loading=\"lazy\" decoding=\"async\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/07\/hemangiob\/hemangihe1.png\" alt=\"\" width=\"388\" height=\"287\" \/><\/a><\/p>\n<p>\u6bdb\u7d30\u8840\u7ba1\u306e\u5897\u6b96\u3092\u4e3b\u3068\u3059\u308breticular variant\u3068\u547c\u79f0\u3055\u308c\u308b\u90e8\u5206\u3082\u3042\u308b\u3002\u5927\u304d\u306a\u8840\u7ba1\u82bd\u816b\u3067\u306fcellular variant\u3068reticular variant\u304c\u6df7\u5728\u3057\u3066\u3042\u308b\u306e\u304c\u901a\u5e38\u3067\u3042\u308b\u3002<\/p>\n<h5>\u6587\u732e<\/h5>\n<h4><strong>\u30d9\u30eb\u30ba\u30c6\u30a3\u30d5\u30a1\u30f3 belzutifan\u304c\u4e00\u90e8\u306e\u8840\u7ba1\u82bd\u816b\u306b\u6709\u52b9<\/strong><\/h4>\n<p>Zhang Y: Neurological applications of belzutifan in von Hippel-Lindau disease. Neuro Oncol 2023<br \/>\nHIF-2\u03b1\u963b\u5bb3\u5264 \u30d9\u30eb\u30ba\u30c6\u30a3\u30d5\u30a1\u30f3 belzutifan\u306f\uff0c\u7d4c\u53e3\u6442\u53d6\u3067\u304d\u308b\u814e\u7d30\u80de\u304c\u3093 (clear cell renal cell cartinoma)\u6de1\u660e\u7d30\u80de\u814e\u7d30\u80de\u764c\uff09\u306e\u6cbb\u7642\u85ac\u3067\u3059\u30022021\u5e74\u306b\u7c73\u56fd\u3067\u8a8d\u53ef\u3055\u308c\u307e\u3057\u305f\u3002\u8133\u810a\u9ac4\u3067\u306f\uff0c<span style=\"color: #000080;\"><strong>30%\u307b\u3069\u306e\u8840\u7ba1\u82bd\u816b\u306b\u6709\u52b9<\/strong><\/span>\u3067\u3042\u308a\uff0c30%\u307b\u3069\u816b\u760d\u4f53\u7a4d\u304c\u6e1b\u308b\u3068\u3044\u3046\u5831\u544a\u304c\u3042\u308a\u307e\u3059\u3002\u9ad8\u5ea6\u306e\u8ca7\u8840\u304c\u6700\u5927\u306e\u6709\u5bb3\u4e8b\u8c61\u3067\uff0c\u4f4e\u9178\u7d20\u75c7\u3068\u75b2\u52b4\u611f\u304c\u6b21\u307e\u3059\u3002\u307e\u3060\u4e2d\u67a2\u795e\u7d4c\u8840\u7ba1\u82bd\u816b\u3078\u306e\u771f\u306e\u52b9\u679c\u306f\u306f\u3063\u304d\u308a\u3057\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n<h4>\u30d9\u30eb\u30ba\u30c6\u30a3\u30d5\u30a1\u30f3\u306f\u8840\u7ba1\u82bd\u816b\u3092\u7e2e\u5c0f\u3059\u308b\u52b9\u679c\u304c\u3042\u308b<\/h4>\n<p class=\"heading-title\">Jonasch E: Belzutifan for Renal Cell Carcinoma in von Hippel-Lindau Disease. N Engl J Med 2021<br \/>\nHIF-2\u03b1\u963b\u5bb3\u5264 \u30d9\u30eb\u30ba\u30c6\u30a3\u30d5\u30a1\u30f3 belzutifan\u304cVHL\u306e\u60a3\u8005\u3055\u3093\u306b\u6295\u4e0e\u3055\u308c\u307e\u3057\u305f\u3002\u4e2d\u67a2\u795e\u7d4c\u306e\u8840\u7ba1\u82bd\u816b\u3067\u306f\uff0c50\u4eba\u4e2d13\u4eba (30%\uff09\u306b\u76ee\u306b\u898b\u3048\u308b\u52b9\u679c\u304c\u3042\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3069\u3093\u306a\u75c5\u6c17\uff1f \u8133\u816b\u760d\u306e\u3046\u3061\u306e\u767a\u751f\u983b\u5ea6\u306f1.7\uff05\u3067\u73cd\u3057\u3044\u816b\u760d\u3067\u3059 \u767a\u751f\u90e8\u4f4d\u306f\u5c0f\u8133\u304c\u4e3b\u3067\uff0c\u305f\u307e\u306b\u5ef6\u9ac4\u3084\u810a\u9ac4\u306b\u3082\u3067\u304d\u307e\u3059 \u767a\u75c7\u5e74\u9f62\u306f10\uff5e50\u6b73\u4ee3\u3067\u3059\u304c\uff0c\u6210\u4eba\u306b\u591a\u3044\u816b\u760d\u3067\u3059 \u305f\u3044\u3066\u3044\u306f\uff11\u3064\u3060\u3051\u5c0f\u8133\u306b\u3067\u304d\u307e\u3059 \u30b0\u30ec\u30fc\u30c91\u306e\u826f\u6027\u816b [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-97","post","type-post","status-publish","format-standard","hentry","category-braintumors"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/97","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/comments?post=97"}],"version-history":[{"count":51,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/97\/revisions"}],"predecessor-version":[{"id":23806,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/97\/revisions\/23806"}],"wp:attachment":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/media?parent=97"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/categories?post=97"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/tags?post=97"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}