{"id":9331,"date":"2016-09-10T20:07:06","date_gmt":"2016-09-10T11:07:06","guid":{"rendered":"\/sawamura\/?p=9331"},"modified":"2025-04-11T16:13:25","modified_gmt":"2025-04-11T07:13:25","slug":"glioblastoma","status":"publish","type":"post","link":"https:\/\/plaza.umin.ac.jp\/sawamura\/pathocase\/glioblastoma\/","title":{"rendered":"\u81a0\u82bd\u816b\u306e\u75c5\u7406 pathology of glioblastoma"},"content":{"rendered":"<h4>WHO 2016\u5e74\u3000\u81a0\u82bd\u816b\u306e\u5206\u985e\u3000\u3059\u3079\u3066\u30b0\u30ec\u30fc\u30c9\uff14\u3067\u3059<\/h4>\n<h5 align=\"left\"><strong><span style=\"color: #000080;\">Glioblastoma, IDH wild-type\u3000IDH\u5909\u7570\u306e\u306a\u3044\u81a0\u82bd\u816b<\/span><\/strong><\/h5>\n<h5 align=\"left\">\u00a0 \u00a0Giant cell glioblastoma\u3000\u5de8\u7d30\u80de\u6027\u81a0\u82bd\u816b<\/h5>\n<h5 align=\"left\">\u3000Gliosarcoma\u3000\u81a0\u8089\u816b<\/h5>\n<h5 align=\"left\">\u3000<a href=\"\/sawamura\/glioma\/epitheloid-glioblastoma\/\">Epithelioid glioblastoma\u3000\u985e\u8868\u76ae\u6027\u81a0\u82bd\u816b<\/a><\/h5>\n<h5><strong><span style=\"color: #000080;\">Glioblastoma, IDH mutant\u00a0 IDH\u5909\u7570\u306e\u3042\u308b\u81a0\u82bd\u816b<\/span><\/strong><\/h5>\n<h5>Glioblastoma \uff08\u907a\u4f1d\u5b50\u8a3a\u65ad\u304c\u3055\u308c\u3066\u306a\u3044\u7d44\u7e54\u8a3a\u65ad\u3060\u3051\u306e\u3082\u306e\uff09<\/h5>\n<hr \/>\n<h4><strong>\u57fa\u672c\u7684\u306b\u306f\uff0cIDH wild type\u00a0<\/strong><strong>\u91ce\u751f\u578b <\/strong><strong>\u3067\u3059<\/strong><\/h4>\n<p>\u514d\u75ab\u67d3\u8272\u3067IDH\u3092\u8abf\u3079\u3066\u308280%\u307b\u3069\u306e\u7cbe\u5ea6\u3067\u3059\u3002\u4e0b\u306e\u3088\u3046\u306a\u907a\u4f1d\u5b50\u5909\u7570\u30b7\u30fc\u30b1\u30f3\u30b9\u89e3\u6790\u3092\u3057\u306a\u3044\u3068\u6b63\u78ba\u306a\u8a3a\u65ad\u3068\u306f\u306a\u308a\u307e\u305b\u3093\u3002FISH\u30671p\/19\u6b20\u5931\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-large wp-image-15077\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/09\/glioblastomaidh-550x334.jpg\" alt=\"\" width=\"550\" height=\"334\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/09\/glioblastomaidh-550x334.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/09\/glioblastomaidh-300x182.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/09\/glioblastomaidh-768x467.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/09\/glioblastomaidh.jpg 984w\" sizes=\"auto, (max-width: 550px) 100vw, 550px\" \/><\/p>\n<p>IDH1 R132 \u91ce\u751f\u578b\uff0cIDH2 R172 \u91ce\u751f\u578b\u3067\u3059\u304b\u3089\u81a0\u82bd\u816b\u3067\u3059\u3002<\/p>\n<h4>\u8089\u773c\u75c5\u7406<\/h4>\n<p>\u75c5\u6b74\u304c\u77ed\u3044\u306b\u3082\u95a2\u308f\u3089\u305a\u3068\u3066\u3082\u5927\u304d\u306a\u816b\u760d\u3068\u306a\u3063\u3066\u767a\u898b\u3055\u308c\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u3002\u524d\u982d\u8449\u5168\u4f53\u3092\u4fb5\u3057\u305f\u308a\uff0c\u5bfe\u5074\u306e\u5927\u8133\u306b\u6d78\u6f64\u3057\u3066\u3044\u308b\u3053\u3068\u3082\u5e0c\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u8133\u5e79\u90e8\u3084\u8133\u6881\u306b\u767a\u751f\u3059\u308b\u3082\u306e\u3067\u306f\u4e21\u5074\u306e\u5927\u8133\u534a\u7403\u306b\u307e\u305f\u304c\u308b\u3082\u306e\u3082\u3042\u308a\u307e\u3059\u3002myelinated structure\uff08\u767d\u8cea\u7dda\u7dad\uff09\u306b\u6cbf\u3063\u3066\u6210\u9577\u3057\uff0c\u8133\u6881\u3092\u4ecb\u3057\u3066\u5bfe\u5074\u306e\u524d\u982d\u8449\u3084\u982d\u9802\u8449\u306b\uff0c\u8133\u5f13\u7dda\u7dad\u306b\u6cbf\u3063\u3066\u5074\u982d\u8449\u306b\u6d78\u6f64\u3059\u308b\u306e\u304c\u7279\u5fb4\u7684\u3067\u3059\u3002<br \/>\n\u8089\u773c\u7684\u306b\u5883\u754c\u306f\u304d\u308f\u3081\u3066\u4e0d\u9bae\u660e\u3067\uff0c\u4e2d\u5fc3\u90e8\u306f\u58ca\u6b7b\u306b\u306a\u3063\u3066\u3044\u307e\u3059 central necrosis\u3002central necrosis\u306f\u81a0\u82bd\u816b\u306e80%\u306b\u8a8d\u3081\u3089\u308c\u307e\u3059\u3002\u5468\u56f2\u306e\u7d30\u80de\u5bc6\u5ea6\u304c\u9ad8\u3044\u5897\u6b96\u3059\u308b\u90e8\u5206\u3067\u306f\uff0c\u67d4\u3089\u304b\u304f\u7070\u8272\u3067\uff0c\u8840\u7ba1\u306b\u5bcc\u307f\u51fa\u8840\u6027\u3067\u3059\u3002\u52d5\u9759\u8108\u30b7\u30e3\u30f3\u30c8\u304c\u3042\u308b\u305f\u3081\u306b\uff0c\u8840\u7ba1\u64ae\u5f71\u3067early venous filling\u304c\u8a8d\u3081\u3089\u308c\u308b\u90e8\u5206\u306b\u306f\uff0cred veins\uff08\u9178\u7d20\u5316\u8840\u306e\u6d41\u308c\uff09\u304c\u307f\u3089\u308c\u51fa\u8840\u50be\u5411\u304c\u8457\u3057\u3044\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u90e8\u5206\u3067\u306f\u81ea\u7136\u306b\u816b\u760d\u5185\u51fa\u8840\u3092\u751f\u3058\uff0c\u65b0\u65e7\u306e\u5c0f\u51fa\u8840\u5de3\u304c\u8a8d\u3081\u3089\u308c\u307e\u3059\u3002\u8133\u5352\u4e2d\u306e\u3088\u3046\u306b\u51fa\u8840\u767a\u75c7\u3057\u3066\u8133\u5185\u51fa\u8840\u3068\u521d\u671f\u8a3a\u65ad\u3055\u308c\u308b\u81a0\u82bd\u816b\u3082\u73cd\u3057\u304f\u3042\u308a\u307e\u305b\u3093\u3002\u58ca\u6b7b\u306e\u5185\u90e8\u306b\u306e\u3046\u80de\u304c\u898b\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u304c\uff0c\u3053\u308c\u306f\u58ca\u6b7b\u7d44\u7e54\u304c\u6db2\u5316\u3057\u305f\u3082\u306e\u3067\u3059\u3002\u307e\u308c\u306b\u8133\u8868\u306b\u767a\u751f\u3057\u3066\u786c\u819c\u306b\u6d78\u6f64\u5897\u6b96\u3057\u3066\u786c\u819c\u52d5\u8108\u3092\u5f15\u304d\u8fbc\u307f\uff0c\u786c\u819c\u8ee2\u79fb\u6027\u8133\u816b\u760d\u3042\u308b\u3044\u306f\u9ac4\u819c\u816b\u3068\u898b\u9593\u9055\u3048\u3089\u308c\u308b\u3088\u3046\u306a\u3082\u306e\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n<h4>\u75c5\u7406\u7d44\u7e54\uff08\u9577\u5d8b\u548c\u90ce\u306e\u75c5\u7406\u6559\u5ba4\uff09<\/h4>\n<ul>\n<li>\u7d30\u80de\u5bc6\u5ea6\u304c\u9ad8\u304f\u672a\u5206\u5316\u306a\u661f\u7d30\u80de astroglia \u304b\u3089\u306a\u308b\u816b\u760d\u3067\u3059<\/li>\n<li><span style=\"color: #000080;\"><strong>\u591a\u578b\u6027 pleomorphism<\/strong><\/span>\u00a0\u304c\u7279\u5fb4\u3067\u3042\u308a\u69d8\u3005\u306a\u5f62\u614b\u3092\u793a\u3059\u7d30\u80de\u304c\u898b\u3089\u308c\u307e\u3059<\/li>\n<li>\u816b\u760d\u7d30\u80de\u306e\u6838\u306f\u5927\u5c0f\u4e0d\u540c\uff08\u6838\u591a\u5f62 nuclear atypia\uff09\u3067\u30af\u30ed\u30de\u30c1\u30f3\u306b\u5bcc\u307f\u3001\u591a\u6570\u306e\u591a\u6838\u5de8\u6838\u7d30\u80de multinucleated giant cells \u3092\u6df7\u3058\u3066\u3001<span style=\"color: #000080;\"><strong>\u5206\u88c2\u50cf mitosis<\/strong><\/span>\u00a0\u3092\u591a\u6570\u307f\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059<\/li>\n<li>\u8a3a\u65ad\u306e\u6839\u62e0\u3068\u306a\u308b\u7279\u5fb4\u7684\u306a\u6240\u898b\u306f\uff0c<span style=\"color: #000080;\"><strong>\u58ca\u6b7b\u50cf necrosis<\/strong><\/span>\u00a0\u306e\u5b58\u5728\u3068<span style=\"color: #000080;\"><strong>\u5fae\u5c0f\u8840\u7ba1\u5897\u6b96 microvascular proliferation<\/strong><\/span>\u00a0\uff08\u8840\u7ba1\u306e\u5185\u76ae\u5897\u6b96\u306b\u3088\u308b\u7cf8\u7403\u4f53\u69d8\u69cb\u9020 glomerular structure\uff09\u3067\u3059<\/li>\n<li>\u58ca\u6b7b\u5468\u56f2\u306e\u6838\u306e<span style=\"color: #000080;\"><strong>\u507d\u67f5\u72b6\u914d\u5217 pseudopalisading<\/strong><\/span>\u00a0\u306f\uff0c\u8a3a\u65ad\u7684\u4fa1\u5024\u304c\u6700\u3082\u9ad8\u3044\u6240\u898b\u3068\u8a00\u3048\u307e\u3059<\/li>\n<li>\u7279\u306bsecondary glioblastoma\u3067\u306f\uff0cdiffuse astrocytoma grade 2\u306e\u90e8\u5206\u50cf\u3092\u542b\u307f\u307e\u3059\u3057\uff0c\u00a0\u305f\u3060\u5358\u8abf\u306b\u5c0f\u578b\u306e\u7d30\u80de\u304c\u5bc6\u306b\u96c6\u7c07\u3059\u308b\u3088\u3046\u306a\u90e8\u5206\u50cf\u3082\u307f\u3089\u308c\u307e\u3059<\/li>\n<li>\u69d8\u3005\u306a\u7d44\u7e54\u50cf\u3092\u6df7\u5728\u3059\u308b\u3053\u3068\u304c\u7279\u5fb4\u3067\uff0c\u591a\u5f62\u81a0\u82bd\u816b\u3000gliombastoma &#8220;multiforme&#8221;\u3068\u3044\u308f\u308c\u308b\u6240\u4ee5\u3067\u3059<\/li>\n<li>WHO\u306e\u6559\u79d1\u66f8\u306b\u3088\u308c\u3070\uff0c\u8a3a\u65ad\u306b\u306f\uff0c<span style=\"color: #000080;\"><strong>highly anaplastic glial cells, mitotic activity, vascular proliferation, and\/or necrosis<\/strong><\/span>\u306e\u6240\u898b\u304c\u5fc5\u8981\u3067\u3042\u308b\u3068\u3055\u308c\u307e\u3059<\/li>\n<li>\u9593\u8449\u7cfb\u5206\u5316\u304c\u898b\u3089\u308c\u308b\u30bf\u30a4\u30d7\u306f\u00a0<span style=\"color: #000080;\"><strong>mesenchymal type<\/strong><\/span>\u3068\u3082\u3044\u308f\u308c\uff0c\u4e88\u5f8c\u304c\u60aa\u3044\u75c5\u7406\u6240\u898b\u3067\u3059<\/li>\n<\/ul>\n<h5>glioblastoma, IDH-wild type\u306eHE\u67d3\u8272\u50cf<\/h5>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/glioblastomahe1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-9273\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/glioblastomahe1-300x229.jpg\" alt=\"glioblastomahe1\" width=\"300\" height=\"229\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/glioblastomahe1-300x229.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/glioblastomahe1-768x587.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/glioblastomahe1-550x420.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/glioblastomahe1.jpg 822w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><br \/>\n\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u753b\u50cf\u304c\u62e1\u5927\u3057\u307e\u3059\u3002<a href=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/glioblastomahe1.jpg\"><br \/>\n<\/a>\u5f31\u62e1\u5927\u50cf\u3067\u3001\u58ca\u6b7bnecrosis (\uff0a)\u3092\u56f2\u3080\u816b\u760d\u7d30\u80de\u6838\u306e\u507d\u67f5\u72b6\u914d\u5217 pseudopalisading pattern (\u2192)\u3092\u793a\u3059\u3002<br \/>\nHE x100.<\/p>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/glioblastomahe2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-9274\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/glioblastomahe2-300x229.jpg\" alt=\"glioblastomahe2\" width=\"300\" height=\"229\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/glioblastomahe2-300x229.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/glioblastomahe2-768x585.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/glioblastomahe2-550x419.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/glioblastomahe2.jpg 798w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><br \/>\n<\/a>\u507d\u67f5\u72b6\u914d\u5217\u306e\u5468\u8fba\u90e8\u306e\u62e1\u5927\u6240\u898b\u3002chromatin\u306b\u5bcc\u3080\u6838\u306e\u816b\u5927\u3068\u591a\u614b\u6027(\u2192)\u3092\u793a\u3059\u816b\u760d\u7d30\u80de\u3068\u8840\u7ba1(V)\u306e\u5897\u52a0\u304c\u898b\u3089\u308c\u308b\u3002<br \/>\nHE x200<\/p>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/glioblastomahe3.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-9275\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/glioblastomahe3-300x224.jpg\" alt=\"glioblastomahe3\" width=\"300\" height=\"224\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/glioblastomahe3-300x224.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/glioblastomahe3-768x574.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/glioblastomahe3-550x411.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/glioblastomahe3.jpg 823w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><br \/>\n<\/a>\u816b\u760d\u7d30\u80de\u6838\u306e\u591a\u614b\u6027\u3068\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u6838\u306e\u816b\u5927(\u9752\u2191)\u304a\u3088\u3073\u6838\u5206\u88c2\u50cf(\u9ed2\u2193\uff09\u304c\u8a8d\u3081\u3089\u308c\u308b\u3002<br \/>\nHE x400<\/p>\n<div>\n<h4><span style=\"color: #000080;\"><strong>de novo (primary) glioblastoma\u3068secondary glioblastoma<\/strong><\/span><\/h4>\n<h5 align=\"left\"><span style=\"color: #000080;\">IDH wildtype \u30d7\u30e9\u30a4\u30de\u30ea\u30fc<\/span><\/h5>\n<p>\u81a0\u82bd\u816b\u306e\u307b\u3068\u3093\u306990%\u304f\u3089\u3044\u306f\u3053\u308c\u3067\u3059\u3002\u5e74\u9f62\u4e2d\u592e\u502462\u6b73\u304f\u3089\u3044\u3067\uff0c\u7a81\u7136\u767a\u751f\u3057\u307e\u3059\u3002\u6570\u30f6\u6708\u524d\u306bMRI\u6b63\u5e38\u3060\u3063\u305f\u306e\u306b\u3068\u3044\u3046\u30bf\u30a4\u30d7\u3067\u3059\u3002\u7537\u6027\u306b\u591a\u304f\u3066\uff0c\u30c6\u30f3\u30c8\u4e0a\u306b\u767a\u751f\u3057\u307e\u3059\u3002\u30ac\u30fc\u30e9\u30f3\u30c9\u5f62\u72b6\uff08Garland shape; \u816b\u760d\u306e\u5468\u56f2\u304c\u7e01\u53d6\u308a\u3055\u308c\u308b\u3088\u3046\u306b\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u5897\u5f37\u3055\u308c\u308b\uff09\u3092\u793a\u3057\u3066\uff0c\u816b\u760d\u5185\u90e8\u306e\u58ca\u6b7b\u304c\u5927\u304d\u3044\u3067\u3059\u3002\u624b\u8853\u653e\u5c04\u7dda\u5316\u5b66\u7642\u6cd5\u3092\u3057\u3066\u306e\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306f15\u30f6\u6708\u3067\u3059\u3002TERT promotor\u5909\u7570\u304c72%\uff0cEGFR\u5897\u5e45\u304c35%\uff0cPTEN\u5909\u7570\u304c24%\u306b\u307f\u3089\u308c\u307e\u3059\u3002<\/p>\n<\/div>\n<h5 align=\"left\">IDH mutant \u30bb\u30ab\u30f3\u30c0\u30ea\u30fc<\/h5>\n<p>10%\u304f\u3089\u3044\u3067\uff0c\u661f\u7d30\u80de\u816b grade II or III \u304c\u60aa\u6027\u5316\u3059\u308b\u3082\u306e\u3067\u3059\u3002\u5e74\u9f62\u4e2d\u592e\u5024\u306f44\u6b73\u3068\u82e5\u3044\u3002\u624b\u8853\u653e\u5c04\u7dda\u5316\u5b66\u7642\u6cd5\u304c\u3067\u304d\u30661\uff0c\u4e2d\u592e\u5024 31\u30f6\u6708\u304f\u3089\u3044\u306e\u751f\u5b58\u671f\u9593\u3067\u3059\u3002\u753b\u50cf\u3067\u306f\uff0c\u524d\u982d\u8449\u306b\u591a\u304f\u307f\u3089\u308c\u816b\u760d\u5185\u58ca\u6b7b\u306f\u5c11\u306a\u3081\u3002<em>TP 53<\/em>\u5909\u7570\u304c81%\uff0c<em>ATRX<\/em>\u5909\u7570\u304c71%\u3068\u9ad8\u7387\u3067\u3059\u3002<\/p>\n<h4 align=\"left\">Gliosarcoma \u81a0\u8089\u816b\u3068\u00a0<a href=\"\/sawamura\/glioma\/epitheloid-glioblastoma\/\">Epithelioid glioblastoma \u985e\u8868\u76ae\u6027\u81a0\u82bd\u816b<\/a><\/h4>\n<p>\u3053\u308c\u3089\u306e\u816b\u760d\u306f\u81a0\u82bd\u816b\u306e variant\u306a\u306e\u3067\u3059\u304c\uff0cMRI\u753b\u50cf\u3092\u307f\u308b\u3068\u81a0\u82bd\u816b\u3067\u306f\u306a\u3044\u3088\u3046\u306b\u898b\u3048\u3066\u3057\u307e\u3063\u3066\uff0c\u624b\u8853\u5f8c\u306b\u81a0\u82bd\u816b\u3060\u3063\u305f\u306e\u304b\u3068\u601d\u3046\u3053\u3068\u304c\u3057\u3070\u3057\u3070\u3067\u3059\u3002\u7406\u7531\u306f\u816b\u760d\u306e\u5883\u754c\u304c\u660e\u77ad\u3067\u304f\u308a\u3093\u3068\u898b\u3048\u308b\u304b\u3089\u3067\u3059\u00a0(sharp demarcation)\u3002\u3044\u308f\u3086\u308bPNET\u307f\u305f\u3044\u306b\u898b\u3048\u307e\u3059\u3002\u8133\u8868\u306b\u767a\u751f\u3057\u305f\u6642\u306b\u306f\uff0c\u786c\u819c\u306b\u63a5\u3057\u3066\u786c\u819c\u8840\u7ba1\u3092\u5f15\u304d\u8fbc\u3093\u3067\u60aa\u6027\u9ac4\u819c\u816b\u306b\u898b\u3048\u305f\u308a\u3057\u307e\u3059\u3002\u5c0f\u5150\u304b\u3089\u82e5\u5e74\u6210\u4eba\u306b\u3082\u767a\u751f\u3059\u308b\u81a0\u82bd\u816b\u3067\u3059\u3002<\/p>\n<h4>glioblastoma with primitive neuronal component<\/h4>\n<p>glioblastoma with PNET-like component\u3068\u3057\u3066\u5831\u544a\u3055\u308c\u3066\u3044\u305f\u4f8b\u3067\u3059\u3002\u795e\u7d4c\u7d30\u80de\u7cfb\u3078\u306e\u5206\u5316\u3092\u793a\u3059\u672a\u5206\u5316\u306a\u7d30\u80de\u304c\u307f\u3089\u308c\u307e\u3059\u3002\u5927\u304d\u306a\u7279\u5fb4\u306f\uff0c\u9ac4\u6db2\u64ad\u7a2e\u3059\u308b\u53ef\u80fd\u6027\u304c\u3068\u3066\u3082\u9ad8\u3044\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u81e8\u5e8a\u7684\u306b\u306fPNET\u306e\u3088\u3046\u306a\u3082\u306e\u3067\u3059\u3002<\/p>\n<div>\n<h4 align=\"left\"><strong>\u5206\u5b50\u30de\u30fc\u30ab\u30fc<\/strong><\/h4>\n<\/div>\n<h5 align=\"left\"><span style=\"color: #ff0000;\"><i>IDH1\/2\u00a0<\/i><span style=\"color: #000080;\">: \u8a3a\u65ad\u306e\u305f\u3081\u306b\u5fc5\u9808\u3067\u3059<\/span><\/span><\/h5>\n<h5 align=\"left\"><span style=\"color: #ff0000;\"><i>MGMT<\/i><span style=\"color: #000080;\">\u00a0: \u6cbb\u7642\u53cd\u5fdc\u6027\u304c\u4e88\u6e2c\u3067\u304d\u307e\u3059\u304b\u3089\u4e00\u90e8\u306e\u8a66\u9a13\u3067\u6cbb\u7642\u6cd5\u9078\u629e\u306b\u5fdc\u7528\u3055\u308c\u3066\u3044\u307e\u3059<\/span><\/span><\/h5>\n<h5 align=\"left\"><strong>1p\/19q<\/strong><\/h5>\n<h5 align=\"left\"><strong><i>EGFR,\u00a0EGFRvIII<\/i><\/strong><\/h5>\n<h5 align=\"left\"><strong><i>p53<\/i><\/strong><\/h5>\n<h5 align=\"left\"><strong><i>PTEN mutation<\/i>\u00a0or deletion<\/strong><\/h5>\n<h5 align=\"left\"><strong><i>PDGFR<\/i><\/strong><\/h5>\n<h5 align=\"left\"><strong><i>PIK3CA<\/i>\u00a0<\/strong><\/h5>\n<p align=\"left\">\u4e0a\u8a18\u306e\u5206\u5b50\u30de\u30fc\u30ab\u30fc\u304c\u6ce8\u76ee\u3055\u308c\u3066\u81e8\u5e8a\u8a66\u9a13\u306e\u4e2d\u3067\u8abf\u3079\u3089\u308c\u3066\u3044\u307e\u3059\uff0c\u8981\u3059\u308b\u306b\u57fa\u790e\u7814\u7a76\u306e\u30bf\u30fc\u30b2\u30c3\u30c8\u3067\u3059\u304c\uff0c2023\u5e74\u6642\u70b9\u3067\u3001<span style=\"color: #000080;\"><strong>\u3053\u308c\u3089\u304c\u89e3\u3063\u305f\u304b\u3089\u3068\u3044\u3063\u3066\u60a3\u8005\u3055\u3093\u306b\u5f79\u306b\u7acb\u3064\u3068\u3044\u3046\u8a33\u3067\u306f\u3042\u308a\u307e\u305b\u3093<\/strong><\/span>\u3002\u81e8\u5e8a\u7684\u306a\u89b3\u70b9\u304b\u3089\u306f\uff0cMGMT status\u3092\u307f\u308b\u3053\u3068\u304c\u6709\u7528\u3067\u3042\u308b\u3068\u8003\u3048\u308b\u7814\u7a76\u8005\u306f\u3054\u304f\u4e00\u90e8\u3068\u3044\u3048\u307e\u3059\u3002\u300cMGMT metilation\u304f\u3089\u3044\u306f\u75c5\u7406\u8a3a\u65ad\u306e\u6642\u306b\u307f\u3066\u304a\u3044\u3066\u3082\u3044\u3044\u304b\u306a\uff1f\u300d\u304f\u3089\u3044\u3067\u3059\u3002<\/p>\n<h5 align=\"left\"><strong><em>Pro neural type<\/em><\/strong><\/h5>\n<h5 align=\"left\"><strong><em>Neural type<\/em><\/strong><\/h5>\n<h5 align=\"left\"><strong><em>Classical type<\/em><\/strong><\/h5>\n<h5 align=\"left\"><strong><em>Mesenchymal type<\/em><\/strong><\/h5>\n<p align=\"left\">\u907a\u4f1d\u5b50\u5909\u7570\u767a\u73fe\u3092\u3082\u3068\u306b\u4e88\u5f8c\u3068\u6cbb\u7642\u52b9\u679c\u3092\u307f\u308b\u305f\u3081\u306b\u7d30\u5206\u985e\u3055\u308c\u305f\u3082\u306e\u3067\u3059\u3002<span style=\"color: #000080;\"><strong>proneural type<\/strong><\/span>\u3068<strong><span style=\"color: #000080;\">mesenchymal type<\/span><\/strong>\u3067\u306fIDH1 wild-type\u3067\u3042\u308b\u524d\u8005\u306e\u65b9\u304c\u6cbb\u7642\u53cd\u5fdc\u6027\u304c\u3088\u3044\u3068\u3055\u308c\u307e\u3059\u30022016\u5e74\u306e\u6642\u70b9\u3067\u306f\u3053\u308c\u304c\u5206\u304b\u3063\u305f\u3044\u3063\u3066\u3082\u60a3\u8005\u3055\u3093\u306b\u5f79\u306b\u7acb\u3064\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<hr \/>\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-1731\" title=\"owlgliob\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/owlgliob.jpg\" alt=\"\" width=\"561\" height=\"709\" \/><\/p>\n<h4>\u9000\u5f62\u6210\u6027\u6027\u661f\u7d30\u80de\u816b\u306b\u4f3c\u305f\u81a0\u82bd\u816b\u306e\u75c5\u7406\u8a3a\u65ad\uff08\u753b\u50cf\u306f\u62e1\u5927\u3067\u304d\u307e\u3059\uff09<\/h4>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-15085\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/09\/glioblastomamthe-4-300x225.jpg\" alt=\"\" width=\"300\" height=\"225\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/09\/glioblastomamthe-4-300x225.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/09\/glioblastomamthe-4-550x413.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/09\/glioblastomamthe-4-768x576.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/09\/glioblastomamthe-4.jpg 850w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-15086\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/09\/glioblastomamthe-3-300x225.jpg\" alt=\"\" width=\"300\" height=\"225\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/09\/glioblastomamthe-3-300x225.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/09\/glioblastomamthe-3-550x413.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/09\/glioblastomamthe-3-768x576.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/09\/glioblastomamthe-3.jpg 850w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>\u6838\u306e\u7570\u5f62\u6210\u304c\u76ee\u7acb\u3061\u5206\u88c2\u50cf\u304c\u898b\u3089\u308c\u8133\u5b9f\u8cea\u3078\u306e\u3073\u307e\u3093\u6027\u6d78\u6f64\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u3060\u3051\u3067\u306f\uff0c\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b \u30b0\u30ec\u30fc\u30c9\uff13\u306e\u3088\u3046\u306b\u307f\u3048\u307e\u3059\u3002<\/p>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/09\/glioblastomamthe-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-15087\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/09\/glioblastomamthe-1-300x225.jpg\" alt=\"\" width=\"300\" height=\"225\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/09\/glioblastomamthe-1-300x225.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/09\/glioblastomamthe-1-550x413.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/09\/glioblastomamthe-1-768x576.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/09\/glioblastomamthe-1.jpg 850w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/09\/glioblastomamtgfap-2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-15089\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/09\/glioblastomamtgfap-2-300x225.jpg\" alt=\"\" width=\"300\" height=\"225\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/09\/glioblastomamtgfap-2-300x225.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/09\/glioblastomamtgfap-2-550x413.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/09\/glioblastomamtgfap-2-768x576.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/09\/glioblastomamtgfap-2.jpg 850w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u9ad8\u5ea6\u306e\u5897\u6b96\uff08\u5de6\u5074\uff09endothelial proliferation \u304c\u3042\u308a\uff0c\u816b\u760d\u7d30\u80de\u306fGFAP\u967d\u6027\u3067\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-15088\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/09\/glioblastomamthe-2-300x225.jpg\" alt=\"\" width=\"300\" height=\"225\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/09\/glioblastomamthe-2-300x225.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/09\/glioblastomamthe-2-550x413.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/09\/glioblastomamthe-2-768x576.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/09\/glioblastomamthe-2.jpg 850w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/09\/glioblastomamtki-67-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-15090\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/09\/glioblastomamtki-67-1-300x225.jpg\" alt=\"\" width=\"300\" height=\"225\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/09\/glioblastomamtki-67-1-300x225.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/09\/glioblastomamtki-67-1-550x413.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/09\/glioblastomamtki-67-1-768x576.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/09\/glioblastomamtki-67-1.jpg 850w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>\u3054\u304f\u4e00\u90e8\u306b\u58ca\u6b7b\u50cf\uff08\u53f3\u5074\uff09\u304c\u8a8d\u3081\u3089\u308c\u3066\uff0cKi-67\u6a19\u8b58\u7387\u306f40%\u306b\u9054\u3057\u307e\u3059\u3002\u7dcf\u5408\u7684\u306b\u306f\u30b0\u30ec\u30fc\u30c9\uff14\u3068\u8a3a\u65ad\u3055\u308c\u307e\u3059\u3002<br \/>\n\u3055\u3089\u306b\uff0c\u30b7\u30fc\u30b1\u30f3\u30b9\u3067IDH-1 R132 wild type, IDH-2 R172 wild type\uff0c\u514d\u75ab\u67d3\u8272\u3067olig 2\u967d\u6027\uff0cp53\u9670\u6027\uff0cATRx\u9670\u6027\uff0cMGMT 1+ (0-4+)\uff0cFISH\u30671p\/19q codeletion (-)\u3092\u78ba\u8a8d\u3057\u307e\u3057\u305f\u3002<br \/>\n\u81a0\u82bd\u816b\u306e\u75c5\u7406\u8a3a\u65ad\u3067\u306f\u3053\u306e\u304f\u3089\u3044\u9762\u5012\u306a\u75c5\u7406\u8a3a\u65ad\u3092\u3057\u307e\u3059\u30022020\u5e74\uff0c\u6b8b\u5ff5\u306a\u304c\u3089\u4fdd\u967a\u8a3a\u7642\u3067\u306f\u30ab\u30d0\u30fc\u3067\u304d\u306a\u3044\u306e\u3067\uff0c\u75c5\u7406\u8a3a\u65ad\u533b\u306e\u7121\u511f\u306e\u5354\u529b\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<h4><strong>20\u5e74\u4ee5\u4e0a \u751f\u5b58\u3057\u305f\u3068\u3044\u3046\u60a3\u8005\u3055\u3093\u304b\u3089\u306e\u624b\u7d19<\/strong><\/h4>\n<p>\u8d85\u9577\u671f\u751f\u5b58\u8005\u304c\u3044\u308b\u304b\u3069\u3046\u304b\u3068\u3044\u3046\u3053\u3068\u304c\u5b66\u4f1a\u3067\u8b70\u8ad6\u306b\u306a\u308a\u307e\u3059\u3002\u8133\u816b\u760d\u5b66\u4f1a\u306710\u5e74\u4ee5\u4e0a\u751f\u5b58\u3057\u3066\u3044\u308b\u60a3\u8005\u3055\u3093\u3092\u8abf\u67fb\u3057\u305f\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u304c\uff0c\u7d50\u5c40\u898b\u3064\u304b\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u75c5\u7406\u8a3a\u65ad\u3092\u898b\u76f4\u3057\u305f\u3089\u5b9f\u306f\u81a0\u82bd\u816b\u3067\u306f\u306a\u304b\u3063\u305f\u3068\u304b\u3067\u3059\u3002<br \/>\n\u4e0b\u306e\u75c5\u7406\u5199\u771f\u306f\uff0c\u3042\u308b\u60a3\u8005\u3055\u3093\u304b\u3089\u79c1\u306b\u9001\u3089\u308c\u305f\u3082\u306e\u3067\u3059\u300220\u4ee3\u3067\u524d\u982d\u8449\u306e\u81a0\u82bd\u816b\u306b\u306a\u3063\u3066\u304b\u308921\u5e74\u7d4c\u3063\u3066\u751f\u5b58\u3057\u3066\u304a\u3089\u308c\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u30022\u5ea6\u306e\u958b\u982d\u8853\u3068\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u5316\u5b66\u7642\u6cd5\uff08\u8907\u6570\u56de\uff09\u3092\u53d7\u3051\u3066\u304a\u3089\u308c\u307e\u3059\u3002\u60a3\u8005\u3055\u3093\u306b\u75c5\u7406\u8a3a\u65ad\u304c\u9593\u9055\u3063\u3066\u3044\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u8fd4\u4e8b\u3092\u3057\u305f\u3089\uff0c\u4e0b\u306b\u3042\u308b\u753b\u50cf\u3092\u9001\u3063\u3066\u304f\u3060\u3055\u3044\u307e\u3057\u305f\u3002\u75c5\u7406\u8a3a\u65ad\u306f\uff0c\u4e00\u898b\u3057\u305f\u3068\u3053\u308d\u306f\u591a\u5f62\u81a0\u82bd\u816b \u30b0\u30ea\u30d6\u30e9\u306b\u9593\u9055\u3044\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3067\u3082\uff0c\u30fc\u30fc\u30fc<br \/>\n\uff08\u4e0b\u306e\u753b\u50cf\u306f\u60a3\u8005\u3055\u3093\u306e\u8a31\u53ef\u3092\u5f97\u3066\u63b2\u8f09\u3055\u305b\u3066\u3044\u305f\u3060\u304d\u307e\u3057\u305f\uff09<\/p>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/gbm20years2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-large wp-image-2980\" title=\"gbm20years\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/gbm20years2-550x381.jpg\" alt=\"\" width=\"550\" height=\"381\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/gbm20years2-550x381.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/gbm20years2-300x208.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/gbm20years2.jpg 800w\" sizes=\"auto, (max-width: 550px) 100vw, 550px\" \/><\/a><\/p>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/ATendvas.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-2985\" title=\"ATendvas\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/ATendvas-300x273.jpg\" alt=\"\" width=\"300\" height=\"273\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/ATendvas-300x273.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/ATendvas.jpg 528w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/ATki67.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-2986\" title=\"ATki67\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/ATki67-300x293.jpg\" alt=\"\" width=\"300\" height=\"293\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/ATki67-300x293.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/ATki67-550x537.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/ATki67.jpg 643w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>bizarre! \u7570\u69d8\u306a\u7d30\u80de\u304c\u6df7\u5728\u3057\u3066\u3044\u307e\u3059\u3002\u6838\u591a\u578b\u304c\u76ee\u7acb\u3061\uff0c\u591a\u6838\u5de8\u7d30\u80de\u3082\u6df7\u3058\u308b\u5178\u578b\u7684\u306a\u81a0\u82bd\u816b\u306e\u50cf\u3067\u3059\u3002\u4e0b\u306e\u5de6\u306e\u753b\u50cf\u306f\u8840\u7ba1\u5185\u76ae\u306e\u80a5\u539a endovascular proliferation\u304c\u3042\u308a\uff0c\u4e0b\u306e\u53f3\u306eKi-67\u67d3\u8272\u3067\u306f\u6838\u6fc3\u67d3\u50cf\u304c\u591a\u304f\u6838\u5206\u88c2\u80fd\u304c\u9ad8\u3044\u3053\u3068\u3092\u793a\u3057\u307e\u3059\u3002\u3057\u304b\u3057\uff0c&#8212;&#8212;<\/p>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/ATgfap.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-2987\" title=\"ATgfap\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/ATgfap-300x280.jpg\" alt=\"\" width=\"300\" height=\"280\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/ATgfap-300x280.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/ATgfap-550x514.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/ATgfap.jpg 654w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/ATvasc.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-2988\" title=\"ATvasc\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/ATvasc-300x293.jpg\" alt=\"\" width=\"300\" height=\"293\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/ATvasc-300x293.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/ATvasc-550x538.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/ATvasc.jpg 645w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>\u5de6\u306eGFAP\u67d3\u8272\u3067\u306f\u4e00\u90e8\u306e\u7d30\u80de\u304c\u67d3\u8272\u3055\u308c\u307e\u305b\u3093\uff0c\u53f3\u306eHE\u67d3\u8272\u3067\u306f\u8c4a\u5bcc\u306a\u8840\u7ba1\u5897\u6b96\u306e\u9593\u306b\u7a7a\u7832 perinuclear halo \u3092\u6709\u3057\u305f\u7d30\u80de\u5897\u6b96\u304c\u898b\u3089\u308c\u307e\u3059\u3002\u3055\u3089\u306b\uff0c&#8211;<\/p>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/AToligcom.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-2989\" title=\"AToligcom\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/AToligcom-300x297.jpg\" alt=\"\" width=\"300\" height=\"297\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/AToligcom-300x297.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/AToligcom-550x546.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/AToligcom.jpg 688w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/ATperiph.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-2990\" title=\"ATperiph\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/ATperiph-300x300.jpg\" alt=\"\" width=\"300\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/ATperiph-300x300.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/ATperiph-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/ATperiph-550x549.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/ATperiph.jpg 704w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>\u816b\u760d\u306e\u90e8\u5206\u50cf\u3068\u3057\u3066\u660e\u3089\u304b\u306b\u4e4f\u7a81\u8d77\u81a0\u816b\u304c\u6df7\u5728\u3057\u3066\u3044\u307e\u3059\u3002\u307e\u305f\uff0c\u3069\u306e\u90e8\u5206\u3092\u307f\u3066\u3082\u58ca\u6b7b necrosis\u304c\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<p>\u5f93\u3063\u3066\uff0c\u3053\u306e\u816b\u760d\u306e\u75c5\u7406\u8a3a\u65ad\u306f\uff0c\u65e7\u7d44\u7e54\u5206\u985e\u306b\u304a\u3051\u308b<span style=\"color: #ff0000;\"><strong><span style=\"color: #000080;\">\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u661f\u7d30\u80de\u816b anaplastic oligoastrocytoma WHO grade III<\/span>\u00a0<\/strong><\/span>\u3068\u306a\u308a\u307e\u3059\u30022021\u5e74\u65b0\u5206\u985e\u3067\u306f<span style=\"color: #000080;\"><strong>\u4e4f\u7a81\u8d77\u81a0\u816b\u30b0\u30ec\u30fc\u30c93<\/strong><\/span>\u3002<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>WHO 2016\u5e74\u3000\u81a0\u82bd\u816b\u306e\u5206\u985e\u3000\u3059\u3079\u3066\u30b0\u30ec\u30fc\u30c9\uff14\u3067\u3059 Glioblastoma, IDH wild-type\u3000IDH\u5909\u7570\u306e\u306a\u3044\u81a0\u82bd\u816b \u00a0 \u00a0Giant cell glioblastoma\u3000\u5de8\u7d30\u80de\u6027\u81a0\u82bd\u816b \u3000Gliosa [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-9331","post","type-post","status-publish","format-standard","hentry","category-pathocase"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/9331","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/comments?post=9331"}],"version-history":[{"count":13,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/9331\/revisions"}],"predecessor-version":[{"id":21669,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/9331\/revisions\/21669"}],"wp:attachment":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/media?parent=9331"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/categories?post=9331"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/tags?post=9331"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}