{"id":8818,"date":"2016-05-08T14:16:31","date_gmt":"2016-05-08T05:16:31","guid":{"rendered":"\/sawamura\/?p=8818"},"modified":"2023-05-17T17:50:43","modified_gmt":"2023-05-17T08:50:43","slug":"anaplastic-astrocytoma","status":"publish","type":"post","link":"https:\/\/plaza.umin.ac.jp\/sawamura\/glioma\/anaplastic-astrocytoma\/","title":{"rendered":"\u661f\u7d30\u80de\u816b\u30b0\u30ec\u30fc\u30c93\uff08\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b anaplastic astrocytoma\uff09"},"content":{"rendered":"<ul>\n<li>\u300c\u305f\u3044\u3051\u3044\u305b\u3044\u305b\u3044 \u305b\u3044\u3055\u3044\u307c\u3046\u3057\u3085\u300d\u3068\u8aad\u307f\u307e\u3059<\/li>\n<li>WHO 2021\u5e74\u5206\u985e\u3067\u306f\u300c\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u300d\u306e\u540d\u524d\u304c\u5ec3\u3055\u308c\u3066\uff0c\u661f\u7d30\u80de\u816b\u30b0\u30ec\u30fc\u30c93\u3068\u547c\u3076\u3053\u3068\u306b\u306a\u308a\u307e\u3057\u305f<\/li>\n<li><span style=\"color: #000080;\"><strong>\u30b0\u30ec\u30fc\u30c93\u306e\u60aa\u6027\u816b\u760d<\/strong><\/span>\u3067\u3059<\/li>\n<li>\u661f\u7d30\u80de\u7cfb\u816b\u760d\u306e\u4ef2\u9593\u3067\u3059<\/li>\n<li>\u696d\u754c\u7528\u8a9e\u3067\uff0canaplastic astrocytoma\u3067\u3059\u304b\u3089<span style=\"color: #000080;\"><strong>AA \u30a8\u30a4\u30a8\u30a4<\/strong><\/span> \u3068\u3044\u3044\u307e\u3059<\/li>\n<li>IDH\u5909\u7570\u304c\u3042\u308b\u3082\u306e\u3067\u306e\u767a\u75c7\u5e74\u9f62<strong><span style=\"color: #000080;\">\u4e2d\u592e\u5024\u306f36\u6b73<\/span><\/strong>\u3067\u3059<\/li>\n<li>\u5927\u8133\u306b\u591a\u3044\u306e\u3067\u3059\u304c\uff0c\u5c0f\u8133\u306b\u767a\u751f\u3059\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059<\/li>\n<li>\u4e16\u754c\u7684\u306b\u78ba\u7acb\u3055\u308c\u305f<span style=\"color: #000080;\"><strong>\u6a19\u6e96\u6cbb\u7642\u306f\uff0c\u624b\u8853\u6458\u51fa\u306e\u5f8c\u3067\uff0c\u5c40\u6240\u653e\u5c04\u7dda\u6cbb\u7642\uff0c\u30c6\u30e2\u30c0\u30fc\u30eb\u5316\u5b66\u7642\u6cd5<\/strong><\/span>\u3067\u3059<\/li>\n<li>\u300c\u6cbb\u308b\u300d\u3068\u3044\u3046\u671f\u5f85\u304c\u3082\u3066\u308b\u30b0\u30ea\u30aa\u30fc\u30de\u3067\u3059<\/li>\n<li>IDH\u5909\u7570\u3092\u30b7\u30fc\u30af\u30a8\u30f3\u30b9\u3067\u3057\u3063\u304b\u308a\u8abf\u3079\u308b\u3068\uff0c<span style=\"color: #000080;\"><strong>\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\u30b0\u30ec\u30fc\u30c92\u306b\u8fd1\u3044\u6027\u8cea<\/strong><\/span>\u306e\u816b\u760d\u3068\u8a00\u3048\u307e\u3059<\/li>\n<li>\u518d\u767a\u6642\u306b\u306f\uff0c\u7d44\u7e54\u50cf\u3067\u306e\u60aa\u6027\u5ea6\u304c\u5897\u3057\u3066\u81a0\u82bd\u816b\u306b\u5909\u5316\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\uff0cIDH\u5909\u7570\u304c\u4fdd\u305f\u308c\u3066\u3044\u308c\u3070 IDH-mutant astrocytoma WHO grade 4\u3068\u547c\u3073\u307e\u3059<\/li>\n<\/ul>\n<hr \/>\n<h4><span style=\"color: #000080;\"><a style=\"color: #000080;\" href=\"\/sawamura\/glioma\/astrocytictumor\/\">\u8a3a\u65ad\u3068\u6cbb\u7642\u306e\u57fa\u672c\u7684\u306a\u8003\u3048\u65b9\u306f\uff0c\u661f\u7d30\u80de\u7cfb\u816b\u760d\u306e\u3068\u3053\u308d\u306b\u3042\u308a\u307e\u3059<br \/>\n\uff08\u3053\u3053\u3092\u30af\u30ea\u30c3\u30af\uff09<\/a><\/span><\/h4>\n<hr \/>\n<h4><a href=\"\/sawamura\/glioma\/glioblastom\/\"><span style=\"color: #000080;\">\u65e5\u672c\u3067\u306e\u6cbb\u7642\u65b9\u6cd5\u306f\uff0c\u307b\u3068\u3093\u3069\u81a0\u82bd\u816b\u3068\u540c\u3058\u3067\u3059\u304c\uff0c\u9593\u9055\u3063\u3066\u3044\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093<\/span><span style=\"color: #000080;\">\uff08\u3053\u3053\u3092\u30af\u30ea\u30c3\u30af\uff09<\/span><\/a><\/h4>\n<hr \/>\n<h5><span style=\"color: #ff0000;\">\u6cbb\u7642\u306e\u524d\u306b\uff0cIDH\u907a\u4f1d\u5b50\u5909\u7570\uff0cIDH 1\/2 mutation\u3092\u5fc5\u305a\u8abf\u3079\u307e\u3059<\/span><\/h5>\n<ul>\n<li>IDH1\/IDH2\u907a\u4f1d\u5b50\u306e\u5909\u7570 mutation \u304c\u3042\u308a\u307e\u3059<\/li>\n<li>\u3082\u3057IDH\u304c\u91ce\u751f\u578b wild-type\u3067\u3042\u308c\u3070\uff0c\u81e8\u5e8a\u7684\u306b\u306f\u81a0\u82bd\u816b\u30b0\u30ec\u30fc\u30c94\u3067\u3059<\/li>\n<li>2021\u5e74\u6642\u70b9\u3067\u306f\uff0c\u91ce\u751f\u578b\u306f\uff0cIDH wild-type astrocytoma WHO grade 4\u3068\u3044\u3044\uff0c\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u304b\u3089\u9664\u5916\u307e\u3059<\/li>\n<\/ul>\n<h5><span style=\"color: #ff0000;\">MGMT\u306e\u30e1\u30c1\u30ec\u30fc\u30b7\u30e7\u30f3<\/span><\/h5>\n<ul>\n<li>\u82f1\u8a9e\u3067\uff0cpromoter methylation of the O6- methyguanine methyltransferase (MGMT) gene<\/li>\n<li>MGMT\u907a\u4f1d\u5b50\u306e\u30e1\u30c1\u30ec\u30fc\u30b7\u30e7\u30f3\u304c\u3042\u308b\u3053\u3068\u304c\u8a3c\u660e\u3067\u304d\u308c\u3070\uff0c\u30c6\u30e2\u30c0\u30fc\u30eb\u5316\u5b66\u7642\u6cd5\u3084\u653e\u5c04\u7dda\u6cbb\u7642\u304c\u3088\u304f\u52b9\u304f\u3068\u3044\u3046\u3053\u3068\u3092\u793a\u3057\u307e\u3059<\/li>\n<li>\u9577\u3044\u751f\u5b58\u671f\u9593\u304c\u671f\u5f85\u3067\u304d\u307e\u3059<\/li>\n<li>\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u3067\u306f<span style=\"color: #000080;\"><strong>\u4e00\u756a\u5927\u5207\u306a\u75c5\u7406\u6240\u898b<\/strong><\/span>\u3067\u3059\u304c\uff0c\u3060\u304b\u3089\u3068\u3044\u3063\u3066\u6cbb\u7642\u65b9\u6cd5\u304c\u5909\u308f\u308b\u308f\u3051\u3067\u3082\u306a\u3044\u306e\u3067\uff0c\u8abf\u3079\u308b\u3053\u3068\u304c\u5fc5\u9808\u3067\u306f\u3042\u308a\u307e\u305b\u3093\uff0c\u8abf\u3079\u306a\u304f\u3066\u3082\u3088\u3044<\/li>\n<\/ul>\n<h4>MRI\u753b\u50cf\u3067\u306e\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\u3068\u306e\u9055\u3044<\/h4>\n<ul>\n<li>\u6d78\u6f64\u80fd\u304c\u9ad8\u3044\u50be\u5411\u304c\u3042\u308a\u307e\u3059<\/li>\n<li>\u767d\u8cea\u306b\u6cbf\u3063\u3066\u8fd1\u508d\u306e\u8133\u306b\u3088\u308a\u5e83\u304f\u5e83\u304c\u3063\u3066\u884c\u304d\u307e\u3059<\/li>\n<li>\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u3067\u90e8\u5206\u7684\u306b\u5897\u5f37\u3055\u308c\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059<\/li>\n<\/ul>\n<h4>diffuse, infiltrative \u3073\u307e\u3093\u6027\u306e\u3082\u306e<\/h4>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastross1-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-9904\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastross1-1-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastross1-1-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastross1-1-144x144.jpg 144w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/a><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastross2-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-9905\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastross2-1-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastross2-1-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastross2-1-144x144.jpg 144w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/a><br \/>\n\u67d3\u307f\u8fbc\u3080\u3088\u3046\u306b\u5de6\u524d\u982d\u5074\u982d\u8449\u304b\u3089\u5cf6\u56de\u306b\u5e83\u304c\u308bAA\u3067\u3059\u3002T2\/\u30d5\u30ec\u30a2\u50cf\u3067\u306b\u3058\u3080\u3088\u3046\u306b\u5e83\u304c\u308a\uff0c\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u5897\u5f37\u3055\u308c\u307e\u305b\u3093\u3002\u30b0\u30ec\u30fc\u30c9 2 (\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b)\u3068\u533a\u5225\u304c\u96e3\u3057\u3044\u3082\u306e\u3067\u3059\u3002<\/p>\n<p>\u3082\u3061\u308d\u3093\u624b\u8853\u6458\u51fa\u3067\u304d\u306a\u3044\u3082\u306e\u3067\uff0c\u751f\u691c\u624b\u8853\u306e\u307f\u3092\u884c\u3044\u307e\u3059\u3002\u3053\u306e\u5927\u304d\u3055\u306e\u3082\u306e\u306b60\u30b0\u30ec\u30a4\u306e\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u3059\u308c\u3070\u9ad8\u5ea6\u306e\u8a8d\u77e5\u6a5f\u80fd\u4f4e\u4e0b\u306f\u907f\u3051\u3089\u308c\u307e\u305b\u3093\u304b\u3089\uff0c\u60a3\u8005\u3055\u3093\u3068\u7167\u5c04\u7dda\u91cf\u3092\u3088\u304f\u3088\u304f\u76f8\u8ac7\u3057\u307e\u3059\u3002\u3067\u3082AA\u306f\u653e\u5c04\u7dda\u5316\u5b66\u7642\u6cd5\u3067\u9577\u671f\u751f\u5b58\u304c\u671b\u3081\u307e\u3059\u300250-54\u30b0\u30ec\u30a4\u306e\u7dda\u91cf\u304c\u9078\u629e\u3055\u308c\u307e\u3059\u3002<\/p>\n<h4>expanding, solid \u56fa\u5f62\u816b\u760d\u7684\u306a\u3082\u306e<\/h4>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastroka1-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-10181\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastroka1-1-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastroka1-1-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastroka1-1-144x144.jpg 144w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/a><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastroka2-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-10182\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastroka2-1-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastroka2-1-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastroka2-1-144x144.jpg 144w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/a><br \/>\n\u58ca\u6b7b\u3067\u306f\u306a\u3044\u300c\u306e\u3046\u80de\u300d\u3092\u4f34\u3044\uff0c\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u3067\u5f37\u304f\u5897\u5f37\u3055\u308c\u307e\u3059\u3002\u30b0\u30ec\u30fc\u30c9 4 (\u81a0\u82bd\u816b)\u3068\u9593\u9055\u3048\u308b\u3088\u3046\u306a\u3082\u306e\u3067\u3059\u3002\u3057\u304b\u3057\uff0c\u306e\u3046\u80de\u306f\u3042\u308a\u307e\u3059\u304c\u4e2d\u5fc3\u58ca\u6b7b\u304c\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<p>\u816b\u760d\u3092\u5927\u90e8\u5206\u6458\u51fa\u3067\u304d\u308b\u306e\u3067\uff0c\u7a4d\u6975\u7684\u306a\u6458\u51fa\u8853\u3092\u3057\u3066\uff0c\u624b\u8853\u5f8c\u306b\u306f\u653e\u5c04\u7dda\u5316\u5b66\u7642\u6cd5\u3092\u52a0\u3048\u307e\u3059\u3002\u3053\u306e\u4f8b\u3067\u306f\uff0c\u624b\u8853\u5f8c\u306e\u653e\u5c04\u7dda\u6cbb\u7642\u8a08\u753b\u306e\u9818\u57df\u304c\u72ed\u3051\u308c\u3070\uff0c60\u30b0\u30ec\u30a4\u3092\u4f7f\u7528\u3067\u304d\u308b\u90e8\u4f4d\u3067\u3059\u3002<\/p>\n<h5>\u6cbb\u7642\u6cd5\u306e\u6982\u7565<\/h5>\n<ul>\n<li>\u53ef\u80fd\u306a\u9650\u308a\u624b\u8853\u3067\u6458\u51fa\u3057\u307e\u3059\uff08\u5168\u90e8\u306f\u7d76\u5bfe\u306b\u3068\u308c\u307e\u305b\u3093\uff09maximal safe resection<\/li>\n<li>\u624b\u8853\u5f8c\u306b\u75c5\u7406\u8a3a\u65ad\u304c\u51fa\u305f\u3089\uff0c\u816b\u760d\u306e\u90e8\u5206\u3068\u305d\u306e\u5468\u8fba2cm\u304f\u3089\u3044\u306e\u6b63\u5e38\u306b\u898b\u3048\u308b\u8133\u306e\u9818\u57df\u3092\u542b\u3093\u3067\u5c40\u6240\u5206\u5272\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u3057\u307e\u3059<\/li>\n<li><span style=\"color: #000080;\"><strong>\u3053\u308c\u307e\u3067\u306e\u653e\u5c04\u7dda\u6cbb\u7642\u306f60\u30b0\u30ec\u30a4 30\u5206\u5272\uff081\u65e52\u30b0\u30ec\u30a4)<\/strong>\u3067\u3057\u305f\u304c\uff0c<strong>\u8fd1\u5e74\u306f\u5c11\u3057\u6e1b\u91cf\u3055\u308c\u3066<\/strong><\/span><span style=\"color: #000080;\"><strong>59.4\u30b0\u30ec\u30a4 33\u5206\u5272\uff081\u65e51.8\u30b0\u30ec\u30a4\uff09<\/strong><\/span>\u3067\u3059<\/li>\n<li>1\u65e5\u7dda\u91cf1.8\u30b0\u30ec\u30a4\u306e\u65b9\u304c\u6c4e\u7528\u3055\u308c\u308b\u50be\u5411\u306b\u3042\u308a\u307e\u3059<\/li>\n<li>\u3067\u3082\u9577\u671f\u751f\u5b58\u306b\u304a\u3051\u308b\u8a8d\u77e5\u6a5f\u80fd\u3092\u8003\u616e\u3059\u308c\u3070\u6b63\u76f4\u3053\u308c\u306f\u304d\u3064\u3044\uff01<\/li>\n<li><span style=\"color: #000080;\"><strong>1\u65e52\u30b0\u30ec\u30a4\u3060\u306827\u56de\uff0c6\u9031\u9593\uff0c\u7dcf\u7dda\u91cf54\u30b0\u30ec\u30a4\u304f\u3089\u3044\u304c\u9069\u5207\u3067\u3057\u3087\u3046<\/strong><\/span><\/li>\n<li>\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u306e\u60a3\u8005\u3055\u3093\u306f\u9577\u671f\u751f\u5b58\u3042\u308b\u3044\u306f\u6cbb\u7652\u3059\u308b\u4eba\u304c\u3044\u307e\u3059<\/li>\n<li>\u5e83\u7bc4\u56f2\u306e60\u30b0\u30ec\u30a4\u3067\u306f5\u5e74\u5f8c\u304f\u3089\u3044\u306e\u8a8d\u77e5\u6a5f\u80fd\uff0f\u9ad8\u6b21\u8133\u6a5f\u80fd\u304c\u304b\u306a\u308a\u843d\u3061\u307e\u3059<\/li>\n<li>\u816b\u760d\u306e\u767a\u751f\u3057\u305f\u90e8\u4f4d\u306b\u3088\u3063\u3066\u306f\uff0c\u5e83\u7bc4\u56f2\u9ad8\u7dda\u91cf\u7167\u5c04\u3067\u6cbb\u3063\u305f\u5f8c\u3067\u793e\u4f1a\u5fa9\u5e30\u3092\u3057\u3066\uff0c\u305d\u306e\u5f8c\u306b\u4f1a\u793e\u3092\u8f9e\u3081\u308b\uff0c\u5bb6\u5ead\u751f\u6d3b\u3092\u5931\u3046\u3053\u3068\u306b\u306a\u308b\u60a3\u8005\u3055\u3093\u304c\u3044\u307e\u3059\uff0c\u9577\u304f\u60a3\u8005\u3055\u3093\u3092\u307f\u3066\u3044\u308b\u3068\u54c0\u3057\u3044\u3053\u3068\u3082\u3042\u308a\u307e\u3059<\/li>\n<li>\u816b\u760d\u306e\u3067\u304d\u305f\u90e8\u4f4d\u306b\u3088\u3063\u3066\u306f\u653e\u5c04\u7dda\u91cf\u3092\u6e1b\u3089\u3059\u3053\u3068\u3082\u5fc5\u8981\u3067\u3059<\/li>\n<li>\u653e\u5c04\u7dda\u6cbb\u7642\u4e2d\u306b\uff0c<span style=\"color: #000080;\"><strong>\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3068\u3044\u3046\u5236\u764c\u5264<\/strong><\/span>\u3092\u6bce\u65e5 75mg\/m2 \u98f2\u307f\u307e\u3059<\/li>\n<li>\u6cbb\u7642\u304c\u7d42\u308f\u3063\u3066\u304b\u3089\u30824\u9031\u9593\u306b5\u65e5\u9593\u3060\u3051\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9 100mg-200mg\/m2 \u3092\u670d\u7528\u3057\u307e\u3059<\/li>\n<li>\u3053\u308c\u309224\u30f6\u6708\u304f\u3089\u3044\u7d99\u7d9a\u3057\u307e\u3059<\/li>\n<li>\u653e\u5c04\u7dda\u6cbb\u7642\u4e2d\u306e\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u304c\u7121\u76ca\u3068\u3044\u3046\u5927\u898f\u6a21\u7814\u7a76\u306e\u4e2d\u9593\u7d50\u679c\u3082\u3042\u308a\u307e\u3059\u304c\uff0c2021\u5e74\uff0c\u73fe\u6642\u70b9\u3067\u306f\u6295\u4e0e\u3059\u308b\u3068\u3044\u3046\u65b9\u5411\u3067\u826f\u3044\u3067\u3057\u3087\u3046<\/li>\n<li><span style=\"color: #000080;\"><strong>2021\u5e74CATNON\u306f\uff0c24\u30b3\u30fc\u30b9\u306e\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u304c\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u309282.3\u30f6\u6708\u307e\u3067\u5ef6\u9577\u3059\u308b<\/strong><\/span>\u3068\u5831\u544a\u3057\u307e\u3057\u305f<\/li>\n<li>\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u6cbb\u7642\u4e2d\u3067\u3082\uff0c\u5916\u6765\u901a\u9662\u3067\u670d\u7528\u3057\u306a\u304c\u3089\u50cd\u304f\u3053\u3068\u304c\u3067\u304d\u307e\u3059<\/li>\n<\/ul>\n<h4>\u81a0\u82bd\u816b\u3068\u306e\u9055\u3044<\/h4>\n<ul>\n<li>\u81a0\u82bd\u816b\u3068\u306e\u9055\u3044\u3067\u610f\u8b58\u3057\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u306e\u306f\uff0c\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u3067\u306f\u9577\u671f\u751f\u5b58\u4f8b\uff0810\u5e74\u3092\u8d85\u3048\u308b\u3042\u308b\u3044\u306f\u6cbb\u7652\u3059\u308b\uff09\u304c\u3042\u308b\u3053\u3068\u3067\u3059<\/li>\n<li>\u3067\u3059\u304b\u3089\uff0c<span style=\"color: #000080;\"><strong>\u793e\u4f1a\u5fa9\u5e30\u306b\u5e0c\u671b\u3092\u3044\u3060\u3044\u3066\u6cbb\u7642\u3059\u308b\u5834\u5408\u306b\u306f\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u5f37\u5ea6\u3092\u306a\u308b\u3079\u304f\u843d\u3068\u3059<\/strong><\/span>\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059<\/li>\n<li>\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u7dda\u91cf\u3068\u7167\u5c04\u7bc4\u56f2\u304c\u5e83\u3044\u3068\uff0c\u8a8d\u77e5\u6a5f\u80fd\uff08\u9ad8\u6b21\u8133\u6a5f\u80fd\uff09\u306e\u4f4e\u4e0b\u304c\u4f55\u5e74\u3082\u304b\u304b\u3063\u3066\u3086\u3063\u304f\u308a\u9032\u884c\u3057\u307e\u3059<\/li>\n<li>\u65e5\u672c\u3067\u591a\u7528\u3055\u308c\u3044\u3066\u3044\u308b\u81a0\u82bd\u816b\u3068\u304a\u306a\u3058\u3088\u3046\u306a60\u30b0\u30ec\u30a4\u3092\u7528\u3044\u308b\u3068\uff0c\u7167\u5c04\u3055\u308c\u305f\u90e8\u5206\u306e\u8133\u6a5f\u80fd\u306f\u304b\u306a\u308a\u843d\u3061\u307e\u3059\u306e\u3067\uff0c54\u30b0\u30ec\u30a4\u4ee5\u4e0b\u306b\u6291\u3048\u308b\u3053\u3068\u304c\u30dd\u30a4\u30f3\u30c8\u3067\u3059<\/li>\n<li>54\u30b0\u30ec\u30a4\u3067\u3082\u4e21\u5074\u524d\u982d\u8449\u3084\u5927\u8133\u534a\u7403\u306e3\u5206\u306e\uff12\u304f\u3089\u3044\u306b\u53ca\u3076\u7167\u5c04\u91ce\u306f\u907f\u3051\u3066\uff0c\u816b\u760d\u306e\u30b3\u30a2\u3060\u3051\u306b\u3057\u3066\u5468\u8fba\u7dda\u91cf\u309250\u30b0\u30ec\u30a4\u7a0b\u5ea6\u306b\u843d\u3068\u3059\u3068\u3044\u3046\u3053\u3068\u3082\u3057\u307e\u3059<\/li>\n<li>\u300c60\u30b0\u30ec\u30a4\u5f53\u3066\u306a\u3044\u3068\u518d\u767a\u3057\u3066\u52a9\u304b\u3089\u306a\u3044\u304b\u3082\u3057\u308c\u306a\u3044\u300d\u62c5\u5f53\u306e\u5148\u751f\u306b\u306f\u8a00\u308f\u308c\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\uff0c\u305d\u308c\u306f\u305d\u3046\u306a\u306e\u3067\u3059\u304c&#8212;-<\/li>\n<\/ul>\n<h4>\u4e88\u5f8c<\/h4>\n<ul>\n<li>\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306f6-7\u5e74\u3067\u3059<\/li>\n<li>\u3067\u3082\u6cbb\u3063\u3066\u3057\u307e\u3063\u3066\u6570\u5341\u5e74\u3068\u3044\u3046\u60a3\u8005\u3055\u3093\u3082\u3044\u307e\u3059\uff0c\u305d\u3053\u304c\u81a0\u82bd\u816b\u3068\u306e\u5927\u304d\u306a\u9055\u3044\u3067\u3059<\/li>\n<li>\u518d\u767a\u3057\u305f\u6642\u306b\u306f\u81a0\u82bd\u816b\u30b0\u30ec\u30fc\u30c94\u306b\u306a\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u304c\uff0c\u3067\u3082\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u30b0\u30ec\u30fc\u30c93\u306e\u307e\u307e\u3067\u3042\u308c\u3070\u307e\u305f\u518d\u6cbb\u7642\u3057\u3066\u3082\u9577\u671f\u751f\u5b58\u304c\u671f\u5f85\u3067\u304d\u307e\u3059<\/li>\n<\/ul>\n<h4>\u3082\u3057\u518d\u767a\u3057\u305f\u3089<\/h4>\n<ul>\n<li>\u4e16\u754c\u6a19\u6e96\u3068\u3044\u3048\u308b\u6cbb\u7642\u6cd5\u306f\u3042\u308a\u307e\u305b\u3093\u304b\u3089\uff0c\u500b\u3005\u306e\u60a3\u8005\u3055\u3093\u306e\u6cbb\u7642\u6b74\u3068\u75c5\u614b\u3092\u8003\u3048\u3066\u76f8\u8ac7\u3057\u306a\u304c\u3089\u884c\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059<\/li>\n<li>\u307e\u305a\uff0c\u624b\u8853\u6458\u51fa\u3067\u304d\u308b\u304b\u3069\u3046\u304b\u8003\u3048\u307e\u3059<\/li>\n<li>\u518d\u624b\u8853\u3057\u3066\u307f\u308b\u3068\uff0cIDH-mutant \u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u306e\u307e\u307e\u3067\u518d\u6cbb\u7642\u304c\u3068\u3066\u3082\u6709\u52b9\u306a\u3053\u3068\u3082\u3042\u308a\uff0c\u4e00\u65b9\u3067\u81a0\u82bd\u816b\u30b0\u30ec\u30fc\u30c94\u306b\u60aa\u6027\u5316\u3057\u3066\u3044\u3066\u518d\u6cbb\u7642\u304c\u96e3\u3057\u3044\u3053\u3068\u3082\u3042\u308a\u307e\u3059<\/li>\n<li>\u521d\u56de\u306e\u653e\u5c04\u7dda\u6cbb\u7642\u304b\u308912\u30f6\u6708\u4ee5\u4e0a\u7d4c\u904e\u3057\u3066\u3044\u308c\u3070\uff0c\u518d\u7167\u5c04\uff08\u8ffd\u52a0\u7167\u5c04\uff09\u304c\u3067\u304d\u308b\u304b\u691c\u8a0e\u3057\u307e\u3059<\/li>\n<li>MGMT\u30e1\u30c1\u30ec\u30fc\u30b7\u30e7\u30f3\u304c\u3042\u308b\u4f8b\u3067\u306f\uff0c\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u518d\u6295\u4e0e\u304c\u6709\u52b9\u3067\u3059<\/li>\n<li>\u521d\u56de\u6cbb\u7642\u3067\u5316\u5b66\u7642\u6cd5\u304c\u884c\u308f\u308c\u3066\u3044\u306a\u3044\u60a3\u8005\u3055\u3093\u3067\u306f\uff0c\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3042\u308b\u3044\u306f\u30cb\u30c8\u30ed\u30bd\u30a6\u30ec\u30a2\u5264\uff08\u65e5\u672c\u3067\u306f\u30cb\u30c9\u30e9\u30f3\uff09\u306e\u6295\u4e0e\u3092\u8003\u616e\u3057\u307e\u3059<\/li>\n<li>\u30a2\u30d0\u30b9\u30c1\u30f3\u6295\u4e0e\u3067\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\u304c\u6570\u30f6\u6708\u4f38\u3073\u308b\u3068\u3044\u3046\u6210\u7e3e\u304c\u3042\u308a\u307e\u3057\u305f\u304c\uff0c2018\u5e74\u306b\u306f\u5426\u5b9a\u7684\u306a\u8ad6\u6587\u304c\u51fa\u307e\u3057\u305f\uff0c\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u5897\u5f37\u3055\u308c\u308b\u816b\u760d\u304c\u5897\u5927\u3057\u3066\u3044\u308b\u6642\u3084\u8133\u6d6e\u816b\u304c\u5f37\u3044\u6642\u306b\u306f\u4f7f\u7528\u3057\u307e\u3059<\/li>\n<\/ul>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/suffolk.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-9901 size-large\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/suffolk-550x413.jpg\" alt=\"\" width=\"550\" height=\"413\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/suffolk-550x413.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/suffolk-300x225.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/suffolk-768x576.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/suffolk.jpg 850w\" sizes=\"auto, (max-width: 550px) 100vw, 550px\" \/><\/a><\/p>\n<p>\u713c\u5c3b\u5cf6\u306e\u30b5\u30d5\u30a9\u30fc\u30af\u7f8a\uff0c\u3068\u3066\u3082\u304a\u3044\u3057\u3044<\/p>\n<h5>\u3053\u3053\u304b\u3089\u4e0b\u306f\u96e3\u3057\u3044<\/h5>\n<h4>\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u306e\u75c5\u7406\u7d44\u7e54<\/h4>\n<ul>\n<li>\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\u3068\u81a0\u82bd\u816b\u3068\u306e\u4e2d\u9593\u306e\u6240\u898b\u3067\u3059<\/li>\n<li>\u81a0\u82bd\u816b\u3068\u306e\u9055\u3044\u306f\uff0c\u816b\u760d\u7d30\u80de\u304c\u6b7b\u3093\u3067\u3044\u308b\u90e8\u5206<span style=\"color: #000080;\"><strong>\uff08\u58ca\u6b7b necrosis\uff09\u304c\u306a\u3044<\/strong><\/span>\u3053\u3068\u304c\u6700\u5927\u306e\u7279\u9577\u3067\u3059<\/li>\n<li>\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\u3068\u306e\u9055\u3044\u306f\uff0c<strong><span style=\"color: #000080;\">\u7d30\u80de\u6838\u306e\u7570\u578b\u6027<\/span><\/strong> anaplasty\u3068<span style=\"color: #000080;\"><strong>\u5206\u88c2\u80fd\u306e\u9ad8\u3055<\/strong><\/span>\u3067\u3059\uff0c\u6838\u306e\u5927\u304d\u3055\u304c\u5927\u5c0f\u4e0d\u540c\u3067\u6b6a\u3093\u3060\u5f62\u3092\u3057\u3066\u3044\u307e\u3059<\/li>\n<li>\u753b\u50cf\u3067\u898b\u3048\u308b\u3088\u308a\u304b\u306a\u308a\u5e83\u7bc4\u56f2\u306b\u5e83\u304c\u3063\u3066\u3044\u3066 single cell infiltration\u3068\u3044\u3044\u307e\u3059<\/li>\n<\/ul>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-11875 size-medium\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrohe1-300x225.jpg\" alt=\"\" width=\"300\" height=\"225\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrohe1-300x225.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrohe1-550x412.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrohe1.jpg 709w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrohe2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-11876 size-medium\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrohe2-300x225.jpg\" alt=\"\" width=\"300\" height=\"225\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrohe2-300x225.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrohe2-550x412.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrohe2.jpg 709w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>\u6838\u306e\u7570\u578b\u6027\uff0c\u591a\u6838\u7d30\u80de\u304c\u76ee\u7acb\u3064\u4f8b\u3067\u3059\u3002\u30b0\u30ec\u30fc\u30c93\u306e\u5178\u578b\u4f8b\u3067\u3059\u3002<\/p>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotnhe-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-14451\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotnhe-1-300x243.jpg\" alt=\"anaplasticastrotnhe\" width=\"300\" height=\"243\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotnhe-1-300x243.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotnhe-1-550x446.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotnhe-1.jpg 709w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><br \/>\n\u6838\u7570\u578b\u6027\u306f\u4e4f\u3057\u3044\u306e\u3067\u3059\u304c\uff0c\u7d30\u80de\u5bc6\u5ea6\u304c\u9ad8\u3044\u4f8b\u3067\uff0cMIB-1\u67d3\u8272\u7387\u306f12\uff05\u3067\u3059\u3002\u30b0\u30ec\u30fc\u30c92\u3068\u9451\u5225\u3057\u3065\u3089\u3044\u3053\u3068\u304c\u3057\u3070\u3057\u3070\u3067\u3059\u3002\u6838\u5206\u88c2\u304c\u6563\u898b\u3055\u308c\u305f\u308aMIB-1\u67d3\u8272\u7387\u304c\u9ad8\u3044\u5834\u5408\u306f\u30b0\u30ec\u30fc\u30c93\u3068\u3057\u3066\u6cbb\u7642\u3092\u3057\u305f\u307b\u3046\u304c\u3044\u3044\u3067\u3057\u3087\u3046\u3002<\/p>\n<h4>\u60aa\u6027\u8ee2\u5316 malignant transformation\uff0c\u81a0\u82bd\u816b\u3078\u306e\u9032\u5c55 progression<\/h4>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastronk11-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-15130\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastronk11-1-300x293.jpg\" alt=\"\" width=\"300\" height=\"293\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastronk11-1-300x293.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastronk11-1-550x537.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastronk11-1-768x750.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastronk11-1.jpg 850w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-15131\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastronk11-2-300x295.jpg\" alt=\"\" width=\"300\" height=\"295\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastronk11-2-300x295.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastronk11-2-550x542.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastronk11-2-768x756.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastronk11-2.jpg 850w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-15132\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastronk11-3-300x300.jpg\" alt=\"\" width=\"300\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastronk11-3-300x300.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastronk11-3-550x548.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastronk11-3-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastronk11-3-768x765.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastronk11-3.jpg 850w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><br \/>\n40\u4ee3\u306e\u60a3\u8005\u3055\u3093\u3067\u3059\u3002\u591c\u9593\u7761\u7720\u4e2d\u306e\u5168\u822c\u767a\u4f5c\uff08\u75c7\u5019\u6027\u3066\u3093\u304b\u3093\uff09\u3067\u767a\u75c7\u3057\u307e\u3057\u305f\u3002\u30d5\u30ec\u30a2\u753b\u50cf\u3067\u5de6\u4e0a\u524d\u982d\u56de\u306b\u6ef2\u3080\u3088\u3046\u306a\u9ad8\u4fe1\u53f7\u9818\u57df\uff08\u767d\u3044\u90e8\u5206\uff09\u304c\u307f\u3089\u308c\u307e\u3059\u3002\u53f3\u5074\u306f\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u5897\u5f37MRI\u3067\u3059\u304c\uff0c\u5168\u304f\u5897\u5f37\u3055\u308c\u307e\u305b\u3093\u3002\u30b0\u30ec\u30fc\u30c92\u304b3\u306e\u661f\u7d30\u80de\u816b\u3042\u308b\u3044\u306f\u4e4f\u7a81\u8d77\u81a0\u816b\u3092\u7591\u3044\u307e\u3059\u3002\u767d\u304f\u6ef2\u3080\u3088\u3046\u306a\u9818\u57df\u306f\u3088\u304f\u898b\u308b\u3068\u304b\u306a\u308a\u5e83\u7bc4\u56f2\u306b\u5e83\u304c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastronkplanning.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-15136\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastronkplanning-300x293.jpg\" alt=\"\" width=\"300\" height=\"293\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastronkplanning-300x293.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastronkplanning-550x537.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastronkplanning-768x749.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastronkplanning.jpg 783w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><br \/>\n\u753b\u50cf\u4e0a\u3067\u306f\u5168\u6458\u51fa gross total removal\u3067\u304d\u3066\uff0c\u75c5\u7406\u8a3a\u65ad\u306f\uff0c\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u661f\u7d30\u80de\u816b anaplastic oligoastrocytoma\u3067\u3057\u305f\u3002IDH\u5909\u7570\u3042\u308a\uff0c1p\/19q\u6b20\u5931\u306a\u3057\u3067\u3059\u3002\u73fe\u5728\u306e\u8a3a\u65ad\u306a\u3089\uff0c\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b \u30b0\u30ec\u30fc\u30c93\u3067\u3059\u3002<br \/>\n\u624b\u8853\u5f8c\u306b54\u30b0\u30ec\u30a4\u306e\u5e83\u7bc4\u56f2\u306a\u5c40\u6240\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u5316\u5b66\u7642\u6cd5\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u5de6\u306e\u753b\u50cf\u306f\u653e\u5c04\u7dda\u6cbb\u7642\u8a08\u753b\u306e\u6642\u306e\u7dda\u91cf\u5206\u5e03\u56f3\u3067\u3059\u3002<\/p>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastronk16-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-15133\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastronk16-1-287x300.jpg\" alt=\"\" width=\"287\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastronk16-1-287x300.jpg 287w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastronk16-1-550x576.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastronk16-1-768x804.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastronk16-1.jpg 850w\" sizes=\"auto, (max-width: 287px) 100vw, 287px\" \/><\/a><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastronk16-2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-15134\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastronk16-2-300x290.jpg\" alt=\"\" width=\"300\" height=\"290\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastronk16-2-300x290.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastronk16-2-550x532.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastronk16-2-768x743.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastronk16-2.jpg 850w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>5\u5e74\u5f8c\u306b\u3044\u304d\u306a\u308a\u6fc0\u3057\u3044\u518d\u767a\u3092\u751f\u3058\u307e\u3057\u305f\u3002\u518d\u767a\u90e8\u4f4d\u306f\uff0c\u653e\u5c04\u7dda\u7167\u5c04\u91ce\u5916 out-of-field\u306e\u524d\u982d\u90e8\u5e2f\u72b6\u56de\u3067\u3057\u305f\u3002\u624b\u8853\u524d\u306b\u6025\u901f\u306b\u5897\u5927\u3057\u3066\uff0c\u753b\u50cf\u6240\u898b\u3082\u521d\u56de\u3068\u5168\u304f\u9055\u3044\u307e\u3057\u305f\u3002\u6458\u51fa\u5f8c\u306e\u75c5\u7406\u306f\uff0cIDH1\/2 wild type, 1p\/19q intact, ATRX negative, MGMT met negative, MIB-1 40%\u3068\u3044\u3046\u5178\u578b\u7684\u306a\u81a0\u82bd\u816b\u306e\u6240\u898b\u3067\u3057\u305f\u3002<\/p>\n<p>\u3053\u306e\u4f8b\u3068\u306f\u7570\u306a\u3063\u3066\uff0c\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u306e\u518d\u767a\u6642\u306b\u306f\uff0cIDH mutant\u306e\u307e\u307e\u306e\u65b9\u304c\u591a\u3044\u3067\u3059\u3002\u3082\u3057\u304b\u3059\u308b\u3068\u5148\u884c\u3057\u305f\u653e\u5c04\u7dda\u8a98\u767a\u81a0\u82bd\u816b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n<h3><span style=\"color: #ff0000;\">anaplastic astrocytoma,IDH-wildtype IDH \u91ce\u751f\u578b<\/span><\/h3>\n<ul>\n<li>\u3053\u306e\u5206\u985e\u306f2021\u5e74\u306b\u306a\u304f\u306a\u308a\u307e\u3057\u305f<\/li>\n<li>\u3073\u307e\u3093\u6027\u306b\u5e83\u7bc4\u6d78\u6f64\u3059\u308b\u661f\u7d30\u80de\u816b\u3067\uff0c\u4e00\u90e8\u3042\u308b\u3044\u306f\u5168\u4f53\u7684\u306b\u6838\u306e\u7570\u578b\u6027\u3068\u9855\u8457\u306a\u5897\u6b96\u6d3b\u6027\u3092\u6709\u3059\u308b\u816b\u760d\u3067\u3059<\/li>\n<li>IDH\u5909\u7570\u578b\u3088\u308a\u9ad8\u3044\u5e74\u9f62\u5c64\u306b\u767a\u751f\u3057\u307e\u3059<\/li>\n<li>2020\u5e74\u307e\u3067\u306eWHO\u5206\u985e\u6559\u66f8\u3067\u306f\uff0c\u7d44\u7e54\u8a3a\u65ad\u306b\u3088\u308b<span style=\"color: #000080;\"><strong>\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u306e20%\u7a0b\u5ea6\u304cIDH wild-type<\/strong><\/span>\u3068\u8a18\u8f09\u3055\u308c\u3066\u3044\u307e\u3057\u305f<\/li>\n<li>\u907a\u4f1d\u5b50\u89e3\u6790\u3067\u306f<span style=\"color: #000080;\"><strong>\u81a0\u82bd\u816b\u306b\u8fd1\u4f3c\u3057\u305fmolecular features<\/strong><\/span>\u3092\u6709\u3057\u307e\u3059<\/li>\n<li>\u307e\u305f\uff0c\u6b63\u4e2d\u306b\u4f4d\u7f6e\u3059\u308b\u3082\u306e\u3067\u306f\uff0cH3 K27M-mutant glioma \uff08\u3073\u307e\u3093\u6027\u6b63\u4e2d\u30b0\u30ea\u30aa\u30fc\u30de\uff09\u306b\u985e\u4f3c\u3059\u308b\u3068\u3055\u308c\u307e\u3059<\/li>\n<li>\u81e8\u5e8a\u7d4c\u904e\u306f\u30b0\u30ec\u30fc\u30c94\u3067\u3059\u304c\uff0c\u7d44\u7e54\u50cf\u306b\u3088\u308b\u30b0\u30ec\u30fc\u30c9\u5206\u985e\u306f &#8220;3&#8221; \u3067\u3059<\/li>\n<li>\u3053\u306e\u30bf\u30a4\u30d7\u306b\u306f\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u304c\u6709\u52b9\u3067\u306f\u306a\u3044\u3068\u3055\u308c\u307e\u3059<\/li>\n<li>\u3082\u306e\u3059\u3054\u304f\u5e83\u3044\u9818\u57df\u306b\u5e83\u304c\u3063\u3066\u3044\u308b\u3082\u306e\u3092<a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/glioma\/gliomatosi\/\"><span style=\"color: #000080;\"><strong>\u30b0\u30ea\u30aa\u30de\u30c8\u30fc\u30b7\u30b9 gliomatosis<\/strong><\/span><\/a>\u3068\u3044\u3044\u307e\u3059<\/li>\n<\/ul>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/astrograde3hk20161.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-21546\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/astrograde3hk20161-296x300.jpg\" alt=\"\" width=\"296\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/astrograde3hk20161-296x300.jpg 296w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/astrograde3hk20161-550x557.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/astrograde3hk20161-768x778.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/astrograde3hk20161.jpg 850w\" sizes=\"auto, (max-width: 296px) 100vw, 296px\" \/><\/a><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-21547\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/astrograde3hk2016-289x300.jpg\" alt=\"\" width=\"289\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/astrograde3hk2016-289x300.jpg 289w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/astrograde3hk2016-550x570.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/astrograde3hk2016-768x796.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/astrograde3hk2016.jpg 850w\" sizes=\"auto, (max-width: 289px) 100vw, 289px\" \/><\/p>\n<p>\u7121\u75c7\u72b6\u3067\u767a\u898b\u3055\u308c\u305f\u82e5\u5e74\u6210\u4eba\u306e\u5de6\u524d\u982d\u8449\u30b0\u30ea\u30aa\u30fc\u30de\u3067\u3059\u3002\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\uff08\u53f3\u5074\uff09\u3067\u306f\u5168\u304f\u5897\u5f37\u3055\u308c\u307e\u305b\u3093\u3002\u624b\u8853\u3067\u5168\u6458\u51fa\u3057\u307e\u3057\u305f\u3002\u7d44\u7e54\u50cf\u306f\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u3067\u3057\u305f\u3002\u58ca\u6b7b\u3082\u8840\u7ba1\u5185\u76ae\u5897\u751f\uff0c\u591a\u6838\u5de8\u7d30\u80de\u306a\u3057\uff0c\u6838\u306e\u816b\u5927\uff0c\u5f62\u4e0d\u6574\uff0c\u591a\u5f62\u6210\u3042\u308a\uff0c<span style=\"color: #000080;\"><strong>\u514d\u75ab\u7d44\u7e54\u67d3\u8272\u3068\u30b7\u30fc\u30af\u30a8\u30f3\u30b9\u3068\u3082\u306bIDH\u91ce\u751f\u578b<\/strong><\/span>\uff0c1p\/19q\u5171\u6b20\u5931\u306a\u3057\uff0cMIB-1\u67d3\u8272\u7387 10%\uff0cnuclearATRX\u6b20\u5931\u3002<br \/>\n\u3053\u306e\u4f8b\u3092\uff0c\u30b0\u30ec\u30fc\u30c93\u3068\u3059\u308b\u304b\u30b0\u30ec\u30fc\u30c94\u3068\u3059\u308b\u304b\u306e\u5b9a\u7fa9\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-21549\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/astrograde3hk2017rad-300x283.jpg\" alt=\"\" width=\"300\" height=\"283\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/astrograde3hk2017rad-300x283.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/astrograde3hk2017rad-550x518.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/astrograde3hk2017rad-768x724.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/astrograde3hk2017rad.jpg 850w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><br \/>\n\u81a0\u82bd\u816b\u30b0\u30ec\u30fc\u30c94\u306b\u6e96\u3058\u305f\u6cbb\u7642\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u62e1\u5927\u5c40\u624050Gy\/25fr, \u5c40\u624010Gy\/5fr\u3068\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u4f75\u7528\u306e\u521d\u671f\u6cbb\u7642\u3068\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u7dad\u6301\u7642\u6cd52\u5e74\u9593\u3067\u3057\u305f\u3002<br \/>\n7\u5e74\u5f8c\u306eMRI\u306b\u306f\u518d\u767a\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<p>\u632f\u308a\u8fd4\u3063\u3066\u898b\u308c\u3070\uff0c\u3053\u306e\u4f8b\u306fIDH\u91ce\u751f\u578b\u3060\u3051\u3069\uff0c\u304d\u3063\u3068\u661f\u7d30\u80de\u816b\u30b0\u30ec\u30fc\u30c9\uff13\u3060\u3063\u305f\u3093\u3067\u3057\u3087\u3046\u3002<\/p>\n<h4>\u30b0\u30ea\u30aa\u30de\u30c8\u30fc\u30b7\u30b9 gliomatosis\u306e\u3088\u3046\u306a\u4f8b<\/h4>\n<p>\u75c5\u7406\u7d44\u7e54\u8a3a\u65ad\u3067\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b WHO grade III\u3068\u3055\u308c\u308b\u3082\u306e\u306b\uff0c\u5168\u304f\u9055\u3063\u305f\u6027\u8cea\u3092\u793a\u3059\u30b0\u30ea\u30aa\u30fc\u30de\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotn1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-16489 size-medium\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotn1-300x293.jpg\" alt=\"\" width=\"300\" height=\"293\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotn1-300x293.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotn1-550x537.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotn1-768x750.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotn1.jpg 850w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-16490 size-medium\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotn2-300x290.jpg\" alt=\"\" width=\"300\" height=\"290\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotn2-300x290.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotn2-550x532.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotn2-768x743.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotn2.jpg 850w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotn3.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-16491\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotn3-300x295.jpg\" alt=\"\" width=\"300\" height=\"295\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotn3-300x295.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotn3-550x541.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotn3-768x755.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotn3.jpg 850w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotn4.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-16492\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotn4-300x296.jpg\" alt=\"\" width=\"300\" height=\"296\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotn4-300x296.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotn4-550x542.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotn4-768x757.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotn4.jpg 850w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>\u3086\u3063\u304f\u308a\u9032\u884c\u3059\u308b\u8efd\u3044\u53f3\u9ebb\u75fa\u3067\u767a\u75c7\u3057\u305f50\u6b73\u304f\u3089\u3044\u306e\u60a3\u8005\u3055\u3093\u3067\u3059\u3002\u8133\u6897\u585e\u3084\u8131\u9ac4\u75be\u60a3\u3092\u7591\u308f\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u5de6\u982d\u9802\u90e8\u76ae\u8cea\u4e0b\u304b\u3089\u8133\u6881\uff0c\u5185\u5305\uff0c\u4e2d\u8133\u5927\u8133\u811a\u307e\u3067\u975e\u5e38\u306b\u5e83\u7bc4\u56f2\u306b\u6d78\u6f64\u3057\u3066\u3044\u307e\u3059\u3002single cell infiltration\u3068\u3044\u3046\u6d78\u6f64\u5f62\u614b\u3092\u60f3\u50cf\u3055\u305b\u307e\u3059\u3002\u53f3\u4e0b\u306fT!\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u9020\u5f71\u3067\uff0c\u3053\u306e\u90e8\u5206\u3060\u3051\u304c\u5897\u5f37\u6240\u898b\u304c\u3042\u308a\u307e\u3059\u3002<br \/>\n\u304a\u305d\u3089\u304f\u4eca\u5f8c\u306f\uff0c<span style=\"color: #000080;\"><strong>diffuse hemispheric glioma WHO grade 4<\/strong><\/span>\u3068\u8a3a\u65ad\u3055\u308c\u307e\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-16493\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotnhe-300x250.jpg\" alt=\"anaplasticastrotnhe\" width=\"300\" height=\"250\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotnhe-300x250.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotnhe-550x458.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotnhe.jpg 709w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><br \/>\n\u8efd\u5ea6\u306e\u7570\u578b\u6027\u3092\u8a8d\u3081\uff0c\u7d30\u80de\u5bc6\u5ea6\u304c\u9ad8\u304f\u6838\u5206\u88c2\u304c\u76ee\u7acb\u3061\uff0cKi-67 (MIB)\u67d3\u8272\u7387\u306f20%\u306b\u9054\u3057\u307e\u3057\u305f\u30021p\/19q\u6b20\u5931\u306f\u306a\u304fMGMT\u30e1\u30c1\u30ec\u30fc\u30b7\u30e7\u30f3\u3082\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002IDH\u5909\u7570\u306f\u8abf\u3079\u3066\u3044\u306a\u3044\u5e74\u4ee3\u306e\u4f8b\u3067\u4e0d\u660e\u3067\u3059\u3002\u75c5\u7406\u7d44\u7e54\u8a3a\u65ad\u3067anaplastic astrocytoma\u3068\u3055\u308c\u307e\u3057\u305f\u3002\u6cbb\u7642\u306f\uff0c\u5168\u8133\u306b\u8fd1\u3044\u7167\u5c04\u91ce\u3068\u306a\u308b\u306e\u306750Gy\/25\u5206\u5272\u304c\u9650\u754c\u3067\u3057\u305f\u3002TMZ\u3092\u4f75\u7528\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotn6.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-16494\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotn6-300x286.jpg\" alt=\"\" width=\"300\" height=\"286\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotn6-300x286.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotn6-550x523.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotn6-768x731.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotn6.jpg 850w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotn7.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-16495\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotn7-294x300.jpg\" alt=\"\" width=\"294\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotn7-294x300.jpg 294w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotn7-550x562.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotn7-768x784.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/anaplasticastrotn7.jpg 850w\" sizes=\"auto, (max-width: 294px) 100vw, 294px\" \/><\/a><\/p>\n<p>\u7167\u5c04\u5f8c\u3082\u75c7\u72b6\u306f\u4e00\u5ea6\u3082\u6539\u5584\u3059\u308b\u3053\u3068\u306a\u304f\u60aa\u5316\u3057\u3066\uff0c\u6570\u30f6\u6708\u5f8c\u306b\u306f\u3082\u3068\u3082\u3068\u816b\u760d\u304c\u898b\u3048\u306a\u304b\u3063\u305f\u5185\u5074\u5074\u982d\u8449\u306b\u5927\u304d\u306a\u816b\u760d\u584a\u304c\u767a\u751f\u5897\u5927\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u4f8b\u306f\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u3068\u8a3a\u65ad\u3059\u308b\u3057\u304b\u306a\u304b\u3063\u305f\u3082\u306e\u3067\u3059\u304c\uff0c2020\u5e74\u6642\u70b9\u3067\u306f\u306f\u3063\u304d\u308a\u5206\u985e\u3067\u304d\u306a\u3044\u661f\u7d30\u80de\u7cfb\u816b\u760d\u3067\u3059\u3002<\/p>\n<p>wild-type AA\u3084\u3053\u306e\u3088\u3046\u306a\u4f8b\u304c\u5206\u5b50\u8a3a\u65ad\u3067\u5f90\u3005\u306b\u9664\u304b\u308c\u3066\u3044\u3051\u3070\uff0c\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b IDH mutant\u306e\u4e88\u5f8c\u306f\u304b\u306a\u308a\u826f\u3044\u3082\u306e\u3068\u7406\u89e3\u3055\u308c\u3066\u304f\u308b\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n<h5>\u6587\u732e\u60c5\u5831<\/h5>\n<h4>\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u306b\u306f\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3060\u3051\u304c\u6709\u52b9<\/h4>\n<p class=\"heading-title\">van den Bent MJ:\u00a0Adjuvant and concurrent temozolomide for 1p\/19q non-co-deleted anaplastic glioma (CATNON; EORTC study 26053-22054): second interim analysis of a randomised, open-label, phase 3 study. Lancet Oncol 2021<strong><br \/>\n<\/strong>CATNON\u30c8\u30e9\u30a4\u30a2\u30eb\u306e\u4e2d\u9593\u5831\u544a\u3067\uff0c\u6b63\u78ba\u306b\u306fIDH\u5909\u7570\u3042\u308a\u304b\u30641p\/19q\u5171\u6b20\u5931\u304c\u306a\u3044\u30b0\u30ec\u30fc\u30c93\u306e\u30b0\u30ea\u30aa\u30fc\u30de\u304c\u5bfe\u8c61\u3067\u3059\u3002\u653e\u5c04\u7dda\u6cbb\u7642\u306f3D-conformal RT\u304bIMRT 59.4Gy\/33fr\u3067\u3059\u3002751\u4f8b\u304c\u767b\u9332\u3055\u308c\uff0c\u8ffd\u8de1\u671f\u9593\u4e2d\u592e\u502456\u30f6\u6708\u3067\u3059\u3002\u653e\u5c04\u7dda\u6cbb\u7642\u4e2d\u306b\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u304c\u6295\u4e0e\u3055\u308c\u308b\u3068\u5168\u751f\u5b58\u671f\u9593 OS\u306f66.9\u30f6\u6708\uff0c\u6295\u4e0e\u306a\u3057\u306760.4\u30f6\u6708\u3067\u6709\u610f\u5dee\u304c\u306a\u304f\u3066\u7121\u76ca\u3068\u306e\u3053\u3068\u3067\u3059\u3002\u4e00\u65b9\u3067\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u5f8c\u306e24\u30b3\u30fc\u30b9\u306e\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u88dc\u52a9\u7642\u6cd5\uff08\u7dad\u6301\u5316\u5b66\u7642\u6cd5\uff09\u306f\u6709\u76ca\u3067\u3042\u308a\uff0c82.3\u30f6\u6708\u306eOS\u304c\u5f97\u3089\u308c\u307e\u3057\u305f\u3002\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306a\u3057\u3067\u306f46.9\u30f6\u6708\u3067\u3059\u3002<\/p>\n<h4>IDH wild-type \u30b0\u30ec\u30fc\u30c93\u306e\u30b0\u30ea\u30aa\u30fc\u30de\u306b\u306f\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u304c\u6709\u52b9\u3067\u306f\u306a\u3044<\/h4>\n<p>van den Bent, M: ACTR-11. Second interim and 1st molecular analysis of the EORTC randomized phase III intergroup CATNON trial on concurrent and adjuvant temozolomide in anaplastic glioma without 1p\/19q codeletion. Neuro Oncol\u00a02019<br \/>\n751\u4f8b\u306e1p\/19q\u6b20\u5931\u306e\u306a\u3044\u30b0\u30ec\u30fc\u30c93\u306b\u5bfe\u3059\u308b\u8a66\u9a13\u3067\u3059\u300259.4\u30b0\u30ec\u30a4\u306e\u653e\u5c04\u7dda\u6cbb\u7642\u306b\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u304c\u52a0\u3048\u3089\u308c\u307e\u3057\u305f\u3002<span style=\"color: #000080;\"><strong>\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306f\uff0cIDH wild-type\u3067\u306f19\u30f6\u6708<\/strong><\/span>\uff0cmutant\u3067\u306f116\u30f6\u6708\u3067\u3057\u305f\u3002\u6975\u7aef\u306b\u8a00\u3048\u30701\u5e74\u306810\u5e74\u306e\u958b\u304d\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u7dad\u6301\u7642\u6cd5\u306fwild type\u306b\u306f\u6709\u52b9\u6027\u304c\u306a\u3044\u3068\u7d50\u8ad6\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<div class=\"article-citation\">\n<h4>CDKN2A\u5171\u6b20\u5931\u306f\u9ad8\u60aa\u6027\u5ea6\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u306e\u4e88\u5f8c\u4e0d\u826f\u56e0\u5b50<\/h4>\n<\/div>\n<p><span class=\"docsum-authors full-authors\">Appay R:\u00a0<\/span>CDKN2A homozygous deletion is a strong adverse prognosis factor in diffuse\u00a0malignant IDH-mutant gliomas. Neuro Oncol 2019<br \/>\nIDH\u5909\u7570\u304c\u3042\u308b\u30b0\u30ec\u30fc\u30c93\u304b4\u306e\u9ad8\u60aa\u6027\u5ea6\u30b0\u30ea\u30aa\u30fc\u30de911\u4f8b\u3067CDKN2A cyclin-dependent kinase inhibitor 2A\u306e\u6b20\u5931\u304c\u8abf\u3079\u3089\u308c\u307e\u3057\u305f\u3002\u7d44\u7e54\u8a3a\u65ad\u3067\u8a00\u3048\u3070\uff0c\u81a0\u82bd\u816bIDHmutant 216\u4f8b\uff0c\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b 212\u4f8b\uff0c\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u81a0\u816b 483\u4f8b\u3067\u3059\u3002\u305d\u308c\u305e\u308c\u306e\u7d44\u7e54\u578b\u306b\u304a\u3044\u3066\uff0c<span style=\"color: #000080;\"><strong>CDKN2A\u304c\u3042\u308b\u3068\u4e88\u5f8c PFS, OS \u304c\u6709\u610f\u306b\u60aa\u3044<\/strong><\/span>\u3068\u306e\u7d50\u8ad6\u3067\u3059\u3002\u52a0\u3048\u3066\u75c5\u7406\u6240\u898b\u3067\u5fae\u5c0f\u8840\u7ba1\u5897\u6b96\u50cf microvascular proliferation\u304c\u3042\u308b\u3068\u4e88\u5f8c\u304c\u60aa\u3044\u3068\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n\u81a0\u82bd\u816b\u306f\u3068\u3082\u304b\u304f\uff0c\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u3068\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u81a0\u816b\u306b\u306f\u4e88\u5f8c\u306e\u5927\u304d\u304f\u9055\u3046\u7fa4\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u305d\u306e\u4e88\u5f8c\u5224\u5225\u306e\u76ee\u5b89\u3068\u306a\u308b\u907a\u4f1d\u5b50\u7570\u5e38\u3068\u6349\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<h4>\u518d\u767a\u6642\u306b\u30a2\u30d0\u30b9\u30c1\u30f3\u3092\u4f7f\u7528\u3057\u3066\u3082\u52b9\u679c\u304c\u306a\u3044<\/h4>\n<p>van den Bent MJ, et al.:\u00a0Bevacizumab\u00a0and\u00a0temozolomide\u00a0in\u00a0patients\u00a0with\u00a0first\u00a0recurrence\u00a0of\u00a0WHO\u00a0grade\u00a0II\u00a0and\u00a0III\u00a0glioma, without\u00a01p\/19q\u00a0co-deletion (TAVAREC): a randomised controlled phase 2 EORTC trial.\u00a0Lancet Oncol.\u00a02018<br \/>\ngrade 2\u304b\uff13\u30671p\/19q\u6b20\u5931\u304c\u306a\u3044\uff0c\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\u304b\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u306e\u518d\u767a\u3067\u3059\u3002\u767b\u9332\u6761\u4ef6\u3068\u3057\u3066\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u5897\u5f37\u521d\u898b\u3092\u4f34\u3046\u518d\u767a\u3068\u66f8\u304b\u308c\u3066\u3044\u308b\u306e\u3067\uff0c\u57fa\u672c\u7684\u306b\u306f\u30a2\u30d0\u30b9\u30c1\u30f3\u304c\u805e\u304d\u305d\u3046\u306a\u4f8b\u3067\u3059\u3002155\u4eba\u306e\u60a3\u8005\u3055\u3093\u304c\u7121\u4f5c\u70ba\u7b2c2\u76f8\u8a66\u9a13\u3092\u53d7\u3051\u307e\u3057\u305f\u30022\u9031\u306b\u4e00\u5ea6\u30a2\u30d0\u30b9\u30c1\u30f310mg\/kg1\u306e\u6295\u4e0e\u3067\u3059\u3002\u518d\u767a\u6cbb\u7642\u958b\u59cb\u5f8c12\u30f6\u6708\u751f\u5b58\u5272\u5408\u306f\uff0c\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u5358\u72ec\u306761%\uff0c\u30a2\u30d0\u30b9\u30c1\u30f3\u3092\u52a0\u3048\u305f\u7fa4\u306755%\u3067\u3057\u305f\u3002\u6709\u5bb3\u4e8b\u8c61\u3082\u591a\u304f\uff0c\u518d\u767a\u306b\u306f\u30a2\u30d0\u30b9\u30c1\u30f3\u3092\u4f7f\u7528\u3057\u306a\u3044\u3068\u7d50\u8ad6\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<h4>\u653e\u5c04\u7dda\u6cbb\u7642\u306b\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\u4f75\u7528\u3057\u305f\u65b9\u304c\u3044\u3044<\/h4>\n<p>van den Bent M, et al .:\u00a0Interim results from the CATNON trial (EORTC study 26053-22054) of treatment with\u00a0concurrentand\u00a0adjuvant\u00a0temozolomide\u00a0for\u00a01p\/19q\u00a0non-co-deleted\u00a0anaplastic\u00a0glioma: a phase 3, randomised, open-label intergroup study. Lancet\u00a02017<br \/>\n<span class=\"highlight\">1p<\/span>\/<span class=\"highlight\">19q<\/span> <span class=\"highlight\">non-co-deleted<\/span> <span class=\"highlight\">anaplastic<\/span> glioma\uff08\u307b\u3068\u3093\u3069\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\uff09745\u4f8b\u306e\u81e8\u5e8a\u8a66\u9a13\u306e\u4e2d\u9593\u5831\u544a\u3067\u3059\u3002\u653e\u5c04\u7dda\u6cbb\u7642\u306b\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\u4f75\u7528\u3057\u305f\u7fa4\u30675\u5e74\u751f\u5b58\u5272\u5408\u304c56%\uff0c\u4f7f\u7528\u3057\u306a\u3044\u306844%\u3068\u3044\u3046\u7d50\u679c\u3067\u3059\u3002\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u7dad\u6301\u7642\u6cd5\u306f12\u30b3\u30fc\u30b9\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<h4>\u518d\u767a\u3057\u305f\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u306b\u5bfe\u3059\u308b\u6cbb\u9a13\u85ac<\/h4>\n<p>2017\u5e74\u7c73\u56fd\u3067\u30a8\u30d5\u30ed\u30eb\u30cb\u30c1\u30f3\u3068\u3044\u3046\u85ac\u5264\u306e\u81e8\u5e8a\u7b2c\uff13\u76f8\u8a66\u9a13\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u3053\u3067\u8208\u5473\u304c\u3042\u308b\u306e\u306f<span style=\"color: #000080;\"><strong>\u30ed\u30e0\u30b9\u30c1\u30f3 CCNU<\/strong><\/span>\u304c\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u30a2\u30fc\u30e0\u3068\u3057\u3066\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u3067\u3059\u3002\u30ed\u30e0\u30b9\u30c1\u30f3\u306f\u5358\u72ec\u3067\u3082\u518d\u767a\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u306b\u591a\u5c11\u306e\u6709\u52b9\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u53e4\u3044\u5b89\u4fa1\u306a\u98f2\u307f\u85ac\u3067\u3059\u304c\u65e5\u672c\u3067\u306f\u4f7f\u7528\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n<h4>\u5909\u7570\u578bIDH1\u9078\u629e\u7684\u963b\u5bb3\u5264\uff08DS-1001\uff09\u306e\u81e8\u5e8a\u8a66\u9a13<\/h4>\n<p>2017\u5e7411\u6708\u6642\u70b9\u3067\uff0cIDH mutation\u306e\u3042\u308b\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u306b\u5bfe\u3059\u308b\u6cbb\u9a13\u304c\u65e5\u672c\u3067\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u5909\u7570\u578b\u30a4\u30bd\u30af\u30a8\u30f3\u9178\u8131\u6c34\u7d20\u9175\u7d20 mutant IDH1\u306b\u5bfe\u3059\u308b\u9078\u629e\u7684\u963b\u5bb3\u5264\uff08DS-1001\uff09\u3092\u7528\u3044\u308b\u3082\u306e\u3067\uff0c\u81e8\u5e8a\u7b2c1\u76f8\u8a66\u9a13\u3067\u3059\u3002\u4e3b\u306b\u85ac\u5264\u6bd2\u6027\u3092\u8abf\u3079\u308b\u6bb5\u968e\u306e\u6cbb\u9a13\u3067\u3042\u308a\uff0c\u52b9\u679c\u306f\u307e\u3060\u307e\u3063\u305f\u304f\u4e0d\u660e\u3067\u3059\u3002<\/p>\n<h4>\u751f\u5b58\u5272\u5408<\/h4>\n<p>Smoll NR: Incidence and relative survival of\u00a0anaplastic\u00a0astrocytomas. Neuro Oncol.\u00a02014<br \/>\n3,202\u4f8b\u306e\u7d71\u8a08\u3067\uff0c\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u306e5\u5e74\u5168\u751f\u5b58\u5272\u5408\u306f23.6%\u3067\u3042\u3063\u305f\u305d\u3046\u3067\u3059\u3002\u6587\u732e\u3067\u306f30-40%\u3068\u3055\u308c\u3066\u3044\u308b\u306e\u3067\u3059\u304c\uff0c\u3053\u308c\u306f\u81e8\u5e8a\u8a66\u9a13\u306a\u3069\u3067\u6cbb\u7642\u304c\u5341\u5206\u306b\u3067\u304d\u305f\u7fa4\u306e\u6cbb\u7642\u6210\u7e3e\u3067\u3042\u308b\u3068\u3044\u3048\u307e\u3059\u3002<\/p>\n<h4>DIH\u304c\u91ce\u751f\u578b\u306a\u3089\u30a2\u30eb\u30ad\u30eb\u5316\u5264\u304c\u6709\u52b9\u304b\u3082\u3057\u308c\u306a\u3044<\/h4>\n<p>Wick W, Meisner C, Hentschel B, et al. Prognostic or predictive value of MGMT promoter methylation in gliomas depends on IDH1 mutation. Neurology 2013<br \/>\nIDH-wild-type tumours and MGMT \u00a0promoter methylation\u304c\u3042\u308b\u60a3\u8005\u3055\u3093\u3067\u30a2\u30eb\u30ad\u30eb\u5316\u5264\u3092\u7528\u3044\u308b\u5316\u5b66\u7642\u6cd5\u304c\u6709\u52b9\u304b\u3082\u3057\u308c\u306a\u3044\u3068\u3044\u3046\u5831\u544a\u3067\u3059\u3002<\/p>\n<h1>\u304a\u307e\u3051<\/h1>\n<h4>\u5ef6\u9ac4\u306e\u3082\u306e\uff1a\u3073\u307e\u3093\u6027\u6b63\u4e2d\u30b0\u30ea\u30aa\u30fc\u30de\u3068\u7d44\u7e54\u9451\u5225\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u304b\uff1f<\/h4>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/medullaaaot1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-10173\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/medullaaaot1-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/medullaaaot1-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/medullaaaot1-144x144.jpg 144w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/a><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-10174\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/medullaaaot2-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/medullaaaot2-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/medullaaaot2-144x144.jpg 144w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><br \/>\n30\u4ee3\u306e\u60a3\u8005\u3055\u3093\u3067\u3059\u3002\u8d77\u7acb\u6027\u4f4e\u8840\u5727\u3084\u547c\u5438\u82e6\uff0c\u53f3\u7247\u9ebb\u75fa\u3068\u591a\u5f69\u306a\u8133\u795e\u7d4c\u75c7\u72b6\u3067\u767a\u75c7\u3057\u307e\u3057\u305f\u3002<br \/>\n\u5de6\u306fT2\u5f37\u8abf\u753b\u50cf\u3067\uff0c\u5ef6\u9ac4\u3092\u4e2d\u5fc3\u3068\u3059\u308b\u3073\u307e\u3093\u6027\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u6240\u898b\u3067\u3059\u3002\u53f3\u306f\u304c\u30c9\u30ea\u30cb\u30a6\u30e0\u5897\u5f37\u50cf\u3067\uff0c\u4e00\u90e8\u304c\u5897\u5f37\u3055\u308c\u3066\u767d\u304f\u898b\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-10175\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/medullaaaot3-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/medullaaaot3-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/05\/medullaaaot3-144x144.jpg 144w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><br \/>\n50.6Gy\/28fr, TMZ 24\u30b3\u30fc\u30b9\u306e\u6cbb\u7642\u3092\u3057\u305f4\u5e74\u5f8c\u306eMRI\u3067\u3059\u3002\u816b\u760d\u306f\u7e2e\u5c0f\u3057\u3066\u56fa\u307e\u3063\u305f\u3088\u3046\u306b\u307f\u3048\uff0c\u75c7\u72b6\u3082\u843d\u3061\u7740\u3044\u3066\u81ea\u5b85\u3067\u66ae\u3089\u305b\u3066\u307e\u3057\u305f\u3002<br \/>\n\u3057\u304b\u3057\u3053\u306e\u5f8c\u306b\uff0c\u6fc0\u3057\u3044\u816b\u760d\u518d\u71c3\u304c\u3042\u308a\u5236\u5fa1\u3067\u304d\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<p>\u8133\u5e79\u90e8\u306b\u767a\u751f\u3059\u308bAA\u3092\uff0c\u753b\u50cf\u3060\u3051\u3067\u300c\u3073\u307e\u3093\u6027\u6b63\u4e2d\u30b0\u30ea\u30aa\u30fc\u30de diffuse midline glioma\u300d \u3068\u533a\u5225\u3059\u308b\u3053\u3068\u306f\u96e3\u3057\u3044\u3067\u3059\u3002\u3060\u3068\u3059\u308c\u3070\u751f\u691c\u624b\u8853\u304c\u5fc5\u8981\u304b ? \u3068\u3044\u3048\u3070\u305d\u3046\u3068\u3082\u8a00\u3048\u307e\u305b\u3093\u3002\u3069\u3061\u3089\u3067\u3042\u3063\u3066\u3082\u6cbb\u7642\u65b9\u6cd5\u306f\u540c\u3058\u3060\u304b\u3089\u3067\u3059\u3002\u305f\u3060\u3057\uff0c\u5e73\u5747\u7684\u306a\u751f\u547d\u4e88\u5f8c\u304c\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u306e\u65b9\u304c\u9577\u304f\uff0c\u6cbb\u308b\u60a3\u8005\u3055\u3093\u3082\u3044\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u300c\u305f\u3044\u3051\u3044\u305b\u3044\u305b\u3044 \u305b\u3044\u3055\u3044\u307c\u3046\u3057\u3085\u300d\u3068\u8aad\u307f\u307e\u3059 WHO 2021\u5e74\u5206\u985e\u3067\u306f\u300c\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u300d\u306e\u540d\u524d\u304c\u5ec3\u3055\u308c\u3066\uff0c\u661f\u7d30\u80de\u816b\u30b0\u30ec\u30fc\u30c93\u3068\u547c\u3076\u3053\u3068\u306b\u306a\u308a\u307e\u3057\u305f \u30b0\u30ec\u30fc\u30c93\u306e\u60aa\u6027\u816b\u760d\u3067\u3059 \u661f\u7d30\u80de\u7cfb\u816b\u760d\u306e\u4ef2\u9593\u3067\u3059 \u696d\u754c\u7528\u8a9e\u3067\uff0ca [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"class_list":["post-8818","post","type-post","status-publish","format-standard","hentry","category-glioma"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/8818","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/comments?post=8818"}],"version-history":[{"count":61,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/8818\/revisions"}],"predecessor-version":[{"id":21550,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/8818\/revisions\/21550"}],"wp:attachment":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/media?parent=8818"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/categories?post=8818"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/tags?post=8818"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}