{"id":8647,"date":"2016-04-16T15:14:57","date_gmt":"2016-04-16T06:14:57","guid":{"rendered":"\/sawamura\/?p=8647"},"modified":"2024-07-30T11:06:05","modified_gmt":"2024-07-30T02:06:05","slug":"pathologymeningioma","status":"publish","type":"post","link":"https:\/\/plaza.umin.ac.jp\/sawamura\/pathocase\/pathologymeningioma\/","title":{"rendered":"\u9ac4\u819c\u816b\u306e\u75c5\u7406 pathology of meningioma"},"content":{"rendered":"<h5 class=\"style1\">\u5927\u5207\u306a\u3053\u3068<\/h5>\n<ul>\n<li class=\"style1\">\u81e8\u5e8a\u533b\u306f\uff0c\u307e\u305a\u9ac4\u819c\u816b\u304c\u30b0\u30ec\u30fc\u30c9\uff11\u304b\uff12\u304b\u306b\u6ce8\u76ee\u3057\u307e\u3059<\/li>\n<li class=\"style1\">\u30b0\u30ec\u30fc\u30c9\uff11\u3067\u3042\u308c\u3070\uff0cMIB-1\u67d3\u8272\u7387\u3092\u307f\u307e\u3059\uff0cMIB\u304c5%\u3092\u8d85\u3048\u308b\u3068\u518d\u767a\u7387\u306f\u9ad8\u3044\u3067\u3059<\/li>\n<li class=\"style1\">\u624b\u8853\u521d\u898b\u3067\uff0c\u8133\u306b\u6d78\u6f64\u304c\u3042\u308c\u3070\u305d\u308c\u3067\u30b0\u30ec\u30fc\u30c9\uff12\u3067\u3059<\/li>\n<li class=\"style1\">\u75c5\u7406\u8a3a\u65ad\u3067\u30b0\u30ec\u30fc\u30c9\uff12\u3068\u3055\u308c\u308c\u3070\u518d\u767a\u306e\u78ba\u7387\u306f\u304b\u306a\u308a\u9ad8\u3044\u3068\u3044\u3048\u307e\u3059<\/li>\n<li class=\"style1\">\u30b0\u30ec\u30fc\u30c9\uff13(\u8089\u816b)\u306f\u307b\u3068\u3093\u3069\u306a\u3044\u306e\u3067\u65e5\u5e38\u7684\u306b\u306f\u6c17\u306b\u3057\u307e\u305b\u3093<\/li>\n<li class=\"style1\">\u3067\u3082\u30b0\u30ec\u30fc\u30c9\uff13\u3068\u3044\u3046\u75c5\u7406\u8a3a\u65ad\u304c\u3064\u3044\u305f\u3089\uff0c\u305d\u308c\u306f\u60a3\u8005\u3055\u3093\u304c\u52a9\u304b\u3089\u306a\u3044\u3068\u3044\u3046\u610f\u5473\u306b\u306a\u308a\u307e\u3059\u306e\u3067\uff0c\u3067\u304d\u308b\u3053\u3068\u306f\u4f55\u3067\u3082\u3057\u3066\u6cbb\u3059\u65b9\u6cd5\u3092\u8003\u3048\u307e\u3059<\/li>\n<li class=\"style1\">\u653e\u5c04\u7dda\u6cbb\u7642\u5f8c\u306b\u518d\u767a\u3057\u3066\u30b0\u30ec\u30fc\u30c9\u304c\u4e0a\u6607\u3059\u308b\u3053\u3068\u306f\u3057\u3070\u3057\u3070\u7d4c\u9a13\u3057\u307e\u3059<\/li>\n<li>\u30b0\u30ec\u30fc\u30c9\uff11\u306e\u9ac4\u819c\u816b\u304c\u518d\u767a\u3092\u7e70\u308a\u8fd4\u3059\u3059\u308b\u305f\u3073\u306b\uff0c\u30b0\u30ec\u30fc\u30c9\u304c\u4e0a\u304c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\uff0c\u3053\u308c\u306f\u6700\u521d\u304b\u3089\u60aa\u6027\u3067\u3042\u3063\u305f\u308f\u3051\u3067\u306f\u306a\u304f\uff0c\u9014\u4e2d\u3067\u60aa\u6027\u5316\u3092\u304d\u305f\u3059\u907a\u4f1d\u5b50\u5909\u7570\u304c\u751f\u3058\u305f\u305f\u3081\u3067\u3059<\/li>\n<\/ul>\n<h4 class=\"style1\"><strong><span style=\"color: #ff0000;\">\u9ac4\u819c\u816b\u306eWHO\u5206\u985e<\/span><\/strong><\/h4>\n<ul>\n<li><strong><span style=\"color: #ff0000;\">Grade I<\/span><\/strong>\uff1a<strong><span style=\"color: #000080;\">meningothlial, fibrous (fibroblastic), transitional (mixed), psammomatous, \u00a0angiomatous, microcystic, secretory, lymphoplasmacyte-rich, and metaplastic meningiomas<\/span><\/strong><\/li>\n<li><strong><span style=\"color: #ff0000;\">Grade II :\u00a0<span style=\"color: #000080;\">atypical meningioma<\/span><\/span><\/strong>\u00a0(mitotic index &gt; 4 in1 high-power fields),<span style=\"color: #000080;\"><strong>\u00a0clear cell meningioma, chordoid meningioma<\/strong><\/span><\/li>\n<li><strong><span style=\"color: #ff0000;\">Grade III :\u00a0<span style=\"color: #000080;\">anaplastic (malignant) meningioma\u00a0<\/span><\/span><\/strong>(mitotic index &gt; 20),<span style=\"color: #000080;\"><strong>\u00a0rhabdoid meningioma, papillary meningioma<\/strong><\/span><\/li>\n<\/ul>\n<p>\u6539\u6b63\u3055\u308c\u305f\u6ce8\u610f\u70b9\uff1a\u53e4\u304f\u304b\u3089\u8133\u3078\u306e\u6d78\u6f64\u304c\u3042\u308b\u9ac4\u819c\u816b\u306f\u518d\u767a\u7387\u304c\u9ad8\u3044\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3057\u305f (Perry 1999)\u3002\u65b0\u3057\u3044\u5b9a\u7fa9\u3067\u306f\uff0cBrain invasion by a meningioma is now an independent criterion for WHO grade II.\u00a0<strong><span style=\"color: #ff0000;\">\u7d44\u7e54\u578b\u306b\u95a2\u308f\u3089\u305a\uff0c\u8133\u3078\u306e\u6d78\u6f64\u304c\u3042\u308b\u9ac4\u819c\u816b\u306fgrade II<\/span><\/strong>\u00a0\u3067\u3059\u3002\u3053\u306e\u5206\u985e\u3067\u306f\u518d\u767a\u7387\u306f\u9ad8\u3044\u3082\u306e\u306e\uff0c\u60a3\u8005\u306e\u6b7b\u4ea1\u5272\u5408\u3068\u95a2\u9023\u3059\u308b\u3082\u306e\u3067\u306f\u306a\u3044\u3053\u3068\u306b\u6ce8\u610f\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u9ad8\u3044\u5897\u6b96\u80fd\u3092\u6709\u3059\u308b\u9ac4\u819c\u816b\u306f mitotic index (MIB-1\u3067\u4ee3\u7528) \u306b\u3088\u3063\u3066grading\u3092\u6c7a\u3081\u307e\u3059\u3002<\/p>\n<p>\u9006\u306b\uff0c<strong><span style=\"color: #ff0000;\">grade III\u306e\u9ac4\u819c\u816b\u306f\u8089\u816b<\/span><\/strong>\u3068\u8003\u3048\u3089\u308c\u6b7b\u4ea1\u5272\u5408\uff08\u816b\u760d\u6b7b\uff09\u306f\u9ad8\u3044\u3067\u3059\u3002grade III \u9ac4\u819c\u816b\u306f\u8133\u3078\u306e\u6d78\u6f64\u3084\u8133\u8840\u7ba1\u3078\u306e\u7652\u7740\u6d78\u6f64\uff0c\u982d\u84cb\u9aa8\uff0c\u7b4b\u8edf\u90e8\u7d44\u7e54\uff0c\u982d\u76ae\u306b\u6df1\u304f\u6d78\u6f64\u3057\u3066\u518d\u71c3\u3092\u7e70\u308a\u8fd4\u3057\u307e\u3059\u3002\u307e\u305f\u96a3\u63a5\u3059\u308b\u786c\u819c\u306a\u3069\u306e\u539f\u767a\u5de3\u8fd1\u508d\u518d\u71c3\u306e\u307f\u306a\u3089\u305a\u5e83\u7bc4\u306b\u982d\u84cb\u5185\u7d44\u7e54\u3078\u8ee2\u79fb\u3057\u305f\u308a\uff0c\u80ba\u306a\u3069\u3078\u306e\u4ed6\u81d3\u5668\u8ee2\u79fb\u3082\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u75c5\u7406\u8a3a\u65ad\u3092\u5f97\u305f\u5834\u5408\u306b\u306f\uff0c\u30ac\u30f3\uff08\u8089\u816b\uff09\u3067\u3042\u308b\u3053\u3068\u3092\u60a3\u8005\u306b\u8aac\u660e\u3057\u3066\uff0c\u53ef\u80fd\u3067\u3042\u308c\u3070\u518d\u624b\u8853\u306b\u3066\u6839\u6cbb\u7684\u90ed\u6e05\u624b\u8853\u3092\u884c\u306a\u3046\u3053\u3068\u3092\u691c\u8a0e\u3057\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093\u3002\u5c11\u306a\u304f\u3068\u3082grade II\u3068III\uff08<strong><span style=\"color: #000080;\">\u9000\u5f62\u6210\u6027\u9ac4\u819c\u816b\uff0c\u30e9\u30d6\u30c9\u30a4\u30c9\u9ac4\u819c\u816b\uff0c\u4e73\u982d\u72b6\u9ac4\u819c\u816b<\/span><\/strong>\uff09\u306e\u9ac4\u819c\u816b\u306e\u7d44\u7e54\u578b\u306f\u8a18\u61b6\u306b\u7559\u3081\u3066\u304a\u3044\u305f\u65b9\u304c\u3088\u3044\u3067\u3057\u3087\u3046\u3002<\/p>\n<hr \/>\n<h5>\u753b\u50cf\u306f\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u62e1\u5927\u3057\u3066\u898b\u3048\u307e\u3059<\/h5>\n<h4><span style=\"color: #000080;\"><strong>storiform pattern\uff08\u9577\u5d8b\u548c\u90ce\u5148\u751f\u306e\u75c5\u7406\u6559\u5ba4\uff09<\/strong><\/span><\/h4>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/storiformpattern1.jpg\" rel=\"attachment wp-att-8653\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-8653 size-medium\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/storiformpattern1-300x225.jpg\" alt=\"storiformpattern1\" width=\"300\" height=\"225\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/storiformpattern1-300x225.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/storiformpattern1-550x413.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/storiformpattern1.jpg 720w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><br \/>\n<\/a>\u7d21\u9318\u5f62\u7d30\u80de\u304c\u653e\u5c04\u72b6\u306b\u914d\u5217\u3059\u308b\u6240\u898b\u3067<span style=\"color: #000080;\"><strong>storiform patten<\/strong><\/span> (\u82b1\u3080\u3057\u308d\uff09\u3001\u307e\u305f\u306fcartwheel (\u8eca\u8f2a)\u72b6\u306b\u4f3c\u305f\u69d8\u5b50\u304c\u898b\u3089\u308c\u307e\u3059\u3002\u8edf\u90e8\u816b\u760d\u3067\u3042\u308bfibrous histiocytoma\u3067\u826f\u304f\u898b\u3089\u308c\u308b\u3082\u306e\u3067\u3059\u3002\u672c\u4f8b\u3067\u306fCP-angle meningioma\u306b\u898b\u3089\u308c\u305f\u6240\u898b\u3067\u3001<strong><span style=\"color: #000080;\">fibrous meningioma<\/span><\/strong>\u306e\u8a3a\u65ad\u3067\u3059\u3002MIB-1 index\u306f\u3084\u3084\u9ad8\u304f8%\u3067\u3057\u305f\u304c\u3001\u58ca\u6b7b\u3084\u7570\u578b\u6027\u306f\u898b\u3089\u308c\u305a\u3001Grade 1\u76f8\u5f53\u3068\u307f\u306a\u3055\u308c\u307e\u3059\u3002HE x200<\/p>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/storiform-pattern2.jpg\" rel=\"attachment wp-att-8652\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-8652 size-medium\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/storiform-pattern2-300x225.jpg\" alt=\"storiform pattern2\" width=\"300\" height=\"225\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/storiform-pattern2-300x225.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/storiform-pattern2-550x413.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/storiform-pattern2.jpg 720w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><br \/>\n<\/a>Fibrous meningioma\u3067\u3059\u304c\u3001\u6e26\u5dfb\u72b6(whorl, long arrow) pattern\u3084\u7389\u306d\u304e\u830e\u72b6 (onion bulb, short arrow) pattern\u306a\u3069\u304c\u898b\u3089\u308c\u307e\u3059\u3002HE x200<\/p>\n<h4><strong>meningothelial meningioma :\u00a0<\/strong><strong>whorl pattern \u6e26\u5dfb\u304d\u5f62\u72b6<\/strong><\/h4>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-7466\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/04\/meningiwhole1-300x282.jpg\" alt=\"meningiwhole\" width=\"300\" height=\"282\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/04\/meningiwhole1-300x282.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/04\/meningiwhole1-550x516.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/04\/meningiwhole1.jpg 600w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/meningiomawhaletehe.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-13379\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/meningiomawhaletehe-300x291.jpg\" alt=\"\" width=\"300\" height=\"291\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/meningiomawhaletehe-300x291.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/meningiomawhaletehe-550x534.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/meningiomawhaletehe.jpg 709w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>\u4ed6\u306e\u90e8\u5206\u306b\u306ffibrous part \u3082\u898b\u3089\u308c\u305ftransitional meningioma\u306e\u75c5\u7406\u50cf\u3067\uff0c<span style=\"color: #000080;\"><strong>meningothelial part<\/strong><\/span>\u3067\u3059\u3002\u9ac4\u819c\u816b\u3067\u306f\u5404\u7d30\u80de\u9593\u306e\u80de\u4f53\u306e\u5883\u754c\u304c\u660e\u77ad\u3067\u306a\u3044\u3053\u3068\u304c\u7279\u5fb4\u3067\u3059\u3002arachnoid cell\u306b\u985e\u4f3c\u3059\u308b\u3068\u3055\u308c\u308bmeningothel\u304c\u30b7\u30fc\u30c8\u72b6\u306b\u914d\u5217\u3057\uff0c\u7d30\u80de\u9593\u5883\u754c\u304c\u306f\u3063\u304d\u308a\u3057\u306a\u3044<span style=\"color: #000080;\"><strong>\u5408\u80de\u7d30\u80de syncytial cell<\/strong> <\/span>\u3068\u306a\u3063\u3066\u3044\u308b\u306e\u304c\u7279\u5fb4\u3067\u3059\u3002<\/p>\n<h4><strong>meningothelial meningioma :\u00a0<\/strong><strong>collagen ball \u30b3\u30e9\u30fc\u30b2\u30f3\u30fb\u30dc\u30fc\u30eb<\/strong><\/h4>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/whorl1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-10128\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/whorl1-300x228.jpg\" alt=\"\" width=\"300\" height=\"228\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/whorl1-300x228.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/whorl1-768x584.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/whorl1-550x418.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/whorl1.jpg 850w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><br \/>\nwhorl pattern\u304c\u5909\u6027\u3059\u308b\u3068\uff0c\u7121\u6a5f\u8cea\u306a\u69cb\u9020\u3078\u3068\u5909\u5316\u3057\u307e\u3059\u3002meningothelial meningioma\u306e\u4e00\u90e8\u50cf\u3068\u3057\u3066\u91cd\u8981\u306a\u6240\u898b\u3067\u3059\u3002\u3053\u308c\u306f\u3068\u3066\u3082\u3086\u3063\u304f\u308a\u5897\u5927\u3059\u308b\u826f\u6027\u306e\u9ac4\u819c\u816b\u306e\u7279\u5fb4\u3067\u3082\u3042\u308a\u307e\u3059\u3002\u4e0b\u306e\u53f3\u5074\u306eMIB-1(Ki-67)\u67d3\u8272\u3067\u306f1\uff05\u304f\u3089\u3044\u304c\u967d\u6027\u3067\u4f4e\u5024\u3068\u8a00\u3048\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/whorl2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-10129\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/whorl2-300x228.jpg\" alt=\"\" width=\"300\" height=\"228\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/whorl2-300x228.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/whorl2-768x584.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/whorl2-550x418.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/whorl2.jpg 850w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/whorl3.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-10130\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/whorl3-300x228.jpg\" alt=\"\" width=\"300\" height=\"228\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/whorl3-300x228.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/whorl3-768x584.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/whorl3-550x418.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/whorl3.jpg 850w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<h4><strong>fibrous meningioma\u00a0\u7dda\u7dad\u6027\u9ac4\u819c\u816b<\/strong><\/h4>\n<p><a href=\"\/sawamura\/casestudy\/meningcases\/attachment\/olympus-digital-camera-20\/\" rel=\"attachment wp-att-2740\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft\" title=\"meningink3\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/04\/meningink33-550x539.jpg\" alt=\"\" width=\"291\" height=\"291\" \/><\/a><img loading=\"lazy\" decoding=\"async\" class=\"alignleft\" title=\"meningink1\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/04\/meningink11-300x276.jpg\" alt=\"\" width=\"304\" height=\"286\" \/><\/p>\n<p>spindle cell\u306e\u5897\u6b96\u304b\u3089\u306a\u308bfibrous meningioma\u3067\u3059\u3002\u795e\u7d4c\u9798\u816b schwannoma\u3068\u306e\u9055\u3044\u306f\uff0cnuclear palisading\u304c\u898b\u3089\u308c\u306a\u3044\u3053\u3068\u3067\u3059\u3002collagen fiber\u306b\u5bcc\u3080\u90e8\u5206\uff08\u53f3\u5074\uff09<\/p>\n<p><a href=\"\/sawamura\/casestudy\/meningcases\/attachment\/olympus-digital-camera-23\/\" rel=\"attachment wp-att-2745\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft\" title=\"meningink2\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/04\/meningink21-300x273.jpg\" alt=\"\" width=\"270\" height=\"246\" \/><br \/>\n<\/a>transitional type\u3068\u306e\u6df7\u5728\u3067\uff0cmeningothelial cell nest\uff08\u53f3\u5074\uff09\u3082\u6df7\u5728\u3057\u307e\u3059\u3002\u4e00\u90e8\u306bnuclear atypia\u3082\u898b\u3089\u308c\u307e\u3059\u304c\uff0catypical meningioma\u306e\u8a3a\u65ad\u306b\u306f\u81f3\u308a\u307e\u305b\u3093\u3002<\/p>\n<h4><strong>psammomatous meningioma \u7802\u7c92\u816b\u6027\u9ac4\u819c\u816b<\/strong><\/h4>\n<p><a href=\"\/sawamura\/casestudy\/meningcases\/attachment\/olympus-digital-camera-34\/\" rel=\"attachment wp-att-3675\"><img loading=\"lazy\" decoding=\"async\" title=\"OLYMPUS DIGITAL CAMERA\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/04\/meningipsammoma1-300x288.jpg\" alt=\"\" width=\"300\" height=\"288\" \/><\/a><a href=\"\/sawamura\/casestudy\/meningcases\/attachment\/olympus-digital-camera-35\/\" rel=\"attachment wp-att-3676\"><img loading=\"lazy\" decoding=\"async\" title=\"OLYMPUS DIGITAL CAMERA\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/04\/meningipsammoma2-300x298.jpg\" alt=\"\" width=\"300\" height=\"298\" \/><\/a><\/p>\n<p>\u305f\u304f\u3055\u3093\u306e<span style=\"color: #000080;\"><strong>\u7802\u7c92\u4f53 psammoma<\/strong><\/span> \u304c\u898b\u3089\u308c\u308b\u9ac4\u819c\u816b\u3067\u3059\u3002\u9855\u5fae\u93e1\u624b\u8853\u3067\u306f\u624b\u8853\u4e2d\u306b\u7d30\u304b\u3044\u7802\u306e\u3088\u3046\u306a\u3082\u306e\u3068\u3057\u3066\u8a8d\u8b58\u3055\u308c\u307e\u3059\u3002\u3053\u306e\u7802\u7c92\u4f53\u306f\u5f90\u3005\u306b\u77f3\u7070\u5316 carcification \u3057\u307e\u3059\u3002\u5199\u771f\u306e\u4e2d\u306e\u7d2b\u8272\u306b\u5909\u5316\u3057\u3066\u3044\u308b\u3068\u3053\u308d\u306f\uff0c\u7802\u7c92\u4f53\u304c\u4e2d\u5fc3\u90e8\u304b\u3089\u77f3\u7070\u5316\u3057\u3066\u884c\u304f\u904e\u7a0b\u3092\u307f\u3066\u3044\u308b\u3082\u306e\u3067\u3059\u3002<\/p>\n<h4><strong>microcystic meningioma \u5fae\u5c0f\u306e\u3046\u80de\u6027\u9ac4\u819c\u816b<\/strong><\/h4>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/cysticmeningsnT1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-20557\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/cysticmeningsnT1-296x300.jpg\" alt=\"\" width=\"296\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/cysticmeningsnT1-296x300.jpg 296w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/cysticmeningsnT1-550x557.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/cysticmeningsnT1.jpg 709w\" sizes=\"auto, (max-width: 296px) 100vw, 296px\" \/><\/a><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/cysticmeningsngd.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-20558\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/cysticmeningsngd-300x298.jpg\" alt=\"\" width=\"300\" height=\"298\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/cysticmeningsngd-300x298.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/cysticmeningsngd-550x546.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/cysticmeningsngd-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/cysticmeningsngd.jpg 709w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>\u6570\u5e74\u9593\u7d4c\u904e\u89b3\u5bdf\u3055\u308c\u3086\u3063\u304f\u308a\u5897\u5927\u3057\u305f\u3082\u306e\u3067\u3059\u3002\u591a\u623f\u6027\u816b\u760d\u3067\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-20548\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/871f65549e3a4e8afcc369f0f2667e35-300x270.jpg\" alt=\"\" width=\"300\" height=\"270\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/871f65549e3a4e8afcc369f0f2667e35-300x270.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/871f65549e3a4e8afcc369f0f2667e35-550x495.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/871f65549e3a4e8afcc369f0f2667e35.jpg 709w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/d9d1a231c3e20f778a0c5db20561ff88.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-20550\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/d9d1a231c3e20f778a0c5db20561ff88-300x289.jpg\" alt=\"\" width=\"300\" height=\"289\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/d9d1a231c3e20f778a0c5db20561ff88-300x289.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/d9d1a231c3e20f778a0c5db20561ff88-550x531.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/d9d1a231c3e20f778a0c5db20561ff88.jpg 709w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/84bf7a37dd127bb2ed3336957519bb78.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-20551\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/84bf7a37dd127bb2ed3336957519bb78-300x287.jpg\" alt=\"\" width=\"300\" height=\"287\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/84bf7a37dd127bb2ed3336957519bb78-300x287.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/84bf7a37dd127bb2ed3336957519bb78-550x526.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/84bf7a37dd127bb2ed3336957519bb78.jpg 700w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><br \/>\n\u591a\u304f\u306e\u306e\u3046\u80de\u3092\u542b\u3080\u9ac4\u819c\u816b\u3067\u3059\u3002\u5b9f\u8cea\u90e8\u5206\u3067\u306f\u985e\u5186\u5f62\u306e\u816b\u5927\u6838\u3092\u6709\u3057\u6838\u5c0f\u4f53\u304c\u660e\u77ad\u306a\u7d30\u80de\u304c\u30b7\u30fc\u30c8\u72b6\u306b\u5897\u751f\u3057\u3066\u3044\u307e\u3059\u3002\u7d30\u80de\u5bc6\u5ea6\u304c\u9ad8\u3044\u90e8\u5206\u304c\u3042\u308a\u307e\u3059\u304c\uff0cMIB-1\u67d3\u8272\u7387\u306f2%\u7a0b\u5ea6\u3067\u3059\u3002WHO grade 1 microcystic meningioma\u306e\u50cf\u3067\u3059\u3002<\/p>\n<h4><strong>xanthomatous change \u9ec4\u8272\u816b\u69d8\u306e\u9ac4\u819c\u816b<\/strong><\/h4>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-14454\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/meningiomaamhe2-300x300.jpg\" alt=\"\" width=\"300\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/meningiomaamhe2-300x300.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/meningiomaamhe2-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/meningiomaamhe2-550x548.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/meningiomaamhe2.jpg 709w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/meningiomaamhe1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-14455\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/meningiomaamhe1-297x300.jpg\" alt=\"\" width=\"297\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/meningiomaamhe1-297x300.jpg 297w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/meningiomaamhe1-550x555.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/meningiomaamhe1.jpg 709w\" sizes=\"auto, (max-width: 297px) 100vw, 297px\" \/><\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-14456\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/meningiomaammib-298x300.jpg\" alt=\"\" width=\"298\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/meningiomaammib-298x300.jpg 298w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/meningiomaammib-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/meningiomaammib-550x554.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/meningiomaammib.jpg 709w\" sizes=\"auto, (max-width: 298px) 100vw, 298px\" \/><br \/>\n\u5c0f\u8133\u6a4b\u89d2\u90e8\u306b\u767a\u751f\u3057\u305f\u9ac4\u819c\u816b\u3067\u3059\u304c\uff0c\u624b\u8853\u4e2d\u306b\u898b\u305f\u76ee\u306b\u771f\u3063\u9ec4\u8272\u3067\u67d4\u3089\u304b\u304f\uff0c\u7e4a\u7dad\u6210\u5206\u306e\u306a\u3044\u58ca\u308c\u3084\u3059\u3044\u8102\u80aa\u7d44\u7e54\u3092\u6458\u51fa\u3057\u3066\u3044\u308b\u3088\u3046\u3067\u3057\u305f\u3002<br \/>\nxanthoma\u3068\u3082\u8868\u73fe\u3067\u304d\u308b\u307b\u3069foamy macrophages\u306e\u6d78\u6f64\u306e\u76ee\u7acb\u3064\u7d44\u7e54\u3067\u3059\u3002<br \/>\nMIB-1\u67d3\u8272\u7387\u306f8-10%\u3068\u9ad8\u304f\uff0c\u81e8\u5e8a\u7684\u306b\u306f\u30b0\u30ec\u30fc\u30c92\u306b\u8fd1\u3044\u6027\u683c\u3092\u793a\u3059\u3082\u306e\u3067\u3059\u3002<\/p>\n<h4><strong>angiomatous meningioma WHO grade 1 \u00a0\u8840\u7ba1\u816b\u69d8\u9ac4\u819c\u816b<\/strong><\/h4>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/angiomatousmeninghy2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-20924\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/angiomatousmeninghy2-284x300.jpg\" alt=\"\" width=\"284\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/angiomatousmeninghy2-284x300.jpg 284w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/angiomatousmeninghy2-550x581.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/angiomatousmeninghy2-768x811.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/angiomatousmeninghy2.jpg 850w\" sizes=\"auto, (max-width: 284px) 100vw, 284px\" \/><\/a><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/angiomatousmeninghy1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-20925\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/angiomatousmeninghy1-300x297.jpg\" alt=\"\" width=\"300\" height=\"297\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/angiomatousmeninghy1-300x297.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/angiomatousmeninghy1-550x544.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/angiomatousmeninghy1-768x760.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/angiomatousmeninghy1.jpg 850w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>\u8853\u524d\u691c\u67fb\u3067\u306f\u307e\u308b\u3067\u81a0\u82bd\u816b\u306e\u3088\u3046\u306a\u753b\u50cf\u3067\u3059\u3002\u3067\u3082\uff0c\u958b\u3051\u3066\u307f\u308c\u3070\u9ac4\u819c\u816b\u3068\u3044\u3046\u3053\u3068\u306f\u3059\u3050\u306b\u308f\u304b\u308b\u8089\u773c\u6240\u898b\u3067\u3059\u3002\u786c\u819c\u306e\u81f3\u308b\u6240\u304b\u3089\u816b\u760d\u8840\u7ba1\u304c\u6d41\u5165\u3057\u3066\u51fa\u8840\u6027\u816b\u760d\u3067\u3059\u3002<\/p>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/22-45598-1-x10.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-20926\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/22-45598-1-x10-300x292.jpg\" alt=\"\" width=\"300\" height=\"292\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/22-45598-1-x10-300x292.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/22-45598-1-x10-550x535.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/22-45598-1-x10.jpg 709w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/22-45598-1-x20-vimentin.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-20927\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/22-45598-1-x20-vimentin-300x285.jpg\" alt=\"\" width=\"300\" height=\"285\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/22-45598-1-x20-vimentin-300x285.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/22-45598-1-x20-vimentin-550x523.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/22-45598-1-x20-vimentin.jpg 709w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>\u591a\u6570\u306e\u5c0f\u8840\u7ba1\u304b\u3089\u69cb\u6210\u3055\u308c\u308b\u7d44\u7e54\u50cf\u3067\u3059\u3002\u53f3\u306evimentin\u67d3\u8272\u306f\u967d\u6027\u3067\u3059\u3002<\/p>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/22-45598-1-x20-3.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-20928\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/22-45598-1-x20-3-300x296.jpg\" alt=\"\" width=\"300\" height=\"296\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/22-45598-1-x20-3-300x296.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/22-45598-1-x20-3-550x542.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/22-45598-1-x20-3.jpg 709w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/22-45598-1-x20-ki-67.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-20929\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/22-45598-1-x20-ki-67-300x283.jpg\" alt=\"\" width=\"300\" height=\"283\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/22-45598-1-x20-ki-67-300x283.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/22-45598-1-x20-ki-67-550x519.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/22-45598-1-x20-ki-67.jpg 709w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>\u6838\u5c0f\u4f53\u660e\u77ad\u306a\u5927\u5c0f\u4e0d\u540c\u306a\u985e\u5186\u5f62\u6838\u304b\u3089\u306a\u308b\u7d30\u80de\u5883\u754c\u304c\u4e0d\u660e\u77ad\u306a\u816b\u760d\u7d30\u80de\u304c\u307f\u3089\u308c\uff0c\u30d8\u30e2\u30b8\u30c7\u30ea\u30f3\u8caa\u98df\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3082\u8a8d\u3081\u3089\u308c\u307e\u3059\u3002MIB-1\u67d3\u8272\u7387\u306f2-3%\u3067\u30b0\u30ec\u30fc\u30c91\u3067\u3059\u3002<\/p>\n<h5>\u60aa\u6027\u5ea6\u306e\u3042\u308b\u3082\u306e<\/h5>\n<h4><strong>atypical meningioma WHO grade 2 \u975e\u5b9a\u578b\uff08\u7570\u578b\u6027\uff09\u9ac4\u819c\u816b\u00a0<\/strong><\/h4>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/04\/meningiatypicalky1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-7410 size-medium\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/04\/meningiatypicalky1-300x280.jpg\" alt=\"meningiatypicalky1\" width=\"300\" height=\"280\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/04\/meningiatypicalky1-300x280.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/04\/meningiatypicalky1-550x513.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/04\/meningiatypicalky1.jpg 886w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/04\/meningiatypicalky2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-7411\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/04\/meningiatypicalky2-300x292.jpg\" alt=\"meningiatypicalky2\" width=\"300\" height=\"292\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/04\/meningiatypicalky2-300x292.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/04\/meningiatypicalky2-550x535.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/04\/meningiatypicalky2.jpg 886w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>\u7d30\u80de\u5bc6\u5ea6\u304c\u9ad8\u304f\uff0c\u82e5\u5e72\u306e\u6838\u7570\u5f62\u6210 anaplasty\u304c\u898b\u3089\u308c\u307e\u3059\u3002MIB-1\u67d3\u8272\u306f15%\u3067\u3057\u305f\u3002\u3053\u306e\u3088\u3046\u306a\u9ac4\u819c\u816b\u306f\u624b\u8853\u8a98\u767a\u8ee2\u79fb\u3059\u308b\u80fd\u529b\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u305f\u3068\u3048\u3070\uff0c\u53f3\u982d\u9802\u90e8\u508d\u77e2\u72b6\u6d1e\u90e8\u306e\u9ac4\u819c\u816b\u3092\u30bd\u30ce\u30da\u30c3\u30c8\u306a\u3069\u306e\u8d85\u97f3\u6ce2\u7834\u7815\u5438\u5f15\u88c5\u7f6e\u3092\u4f7f\u3063\u3066\u6458\u51fa\u3059\u308b\u3068\uff0c\u53f3\u524d\u982d\u84cb\u5e95\u3084\u53f3\u5074\u982d\u90e8\u306e\u96e2\u308c\u305f\u6240\u306b<span style=\"color: #000080;\"><strong>\u8ee2\u79fb\u518d\u767a\u3059\u308b<\/strong><\/span>\u3068\u3044\u3046\u5177\u5408\u3067\u3059\u3002\u8133\u8868\u8ee2\u79fb\u3068\u3082<strong><span style=\"color: #000080;\">\u786c\u819c\u4e0b\u8ee2\u79fb<\/span><\/strong>\u3068\u3082\u3044\u3048\u307e\u3059\u3002\u8981\u3059\u308b\u306b\u624b\u8853\u3067\u7d30\u80de\u3092\u30d0\u30e9\u307e\u304f\u3068\u3044\u308d\u3044\u308d\u306a\u6240\u3067\u6839\u3092\u5f35\u3063\u3066\u6210\u9577\u3059\u308b\u80fd\u529b\u304c\u3042\u308b\u306e\u3067\u3059\u3002<\/p>\n<h4><span style=\"color: #000080;\"><strong>atypical meningioma WHO grade 2\uff08\u9577\u5d8b\u548c\u90ce\u5148\u751f\u306e\u75c5\u7406\u6559\u5ba4\uff09<br \/>\n<\/strong><\/span><\/h4>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/atypicalmeninsk.jpg\" rel=\"attachment wp-att-8774\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-8774\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/atypicalmeninsk-296x300.jpg\" alt=\"atypicalmeninsk\" width=\"219\" height=\"228\" \/><\/a><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/atypicalmeninsy2.png\" rel=\"attachment wp-att-8756\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-8756 size-medium\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/atypicalmeninsy2-300x225.png\" alt=\"atypicalmeninsy2\" width=\"300\" height=\"225\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/atypicalmeninsy2-300x225.png 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/atypicalmeninsy2-550x413.png 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/atypicalmeninsy2.png 720w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>\u9ad8\u9f62\u8005\u306e\u5f8c\u982d\u7aa9 (ptrous ridge) \u306b\u307f\u3089\u308c\u305f\u5927\u304d\u306a\u9ac4\u819c\u816b\u3067\u3057\u305f\u3002meningioma\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u304c\u3001whorl pattern\u3084meningothelial feature\u306a\u3069\u7279\u5fb4\u7684\u306apattern\u304c\u898b\u3089\u308c\u305a<span style=\"color: #000080;\"><strong>pattern less<\/strong><\/span>\u3068\u898b\u505a\u3055\u308c\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u816b\u5927\u3057chromatin\u306b\u5bcc\u3080\u6838\u304c\u898b\u3089\u308c\u3001\u7570\u578b\u7d30\u80de\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/atypicalmeninsy4.png\" rel=\"attachment wp-att-8757\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-8757 size-medium\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/atypicalmeninsy3-300x225.png\" alt=\"atypicalmeninsy3\" width=\"300\" height=\"225\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/atypicalmeninsy3-300x225.png 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/atypicalmeninsy3-550x413.png 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/atypicalmeninsy3.png 720w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-8758 size-medium\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/atypicalmeninsy4-300x225.png\" alt=\"\" width=\"300\" height=\"225\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/atypicalmeninsy4-300x225.png 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/atypicalmeninsy4-550x413.png 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/atypicalmeninsy4.png 720w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p><strong><span style=\"color: #000080;\">EMA\u304c\u967d\u6027<\/span><\/strong>\u3068\u306a\u308b\u3053\u3068\u3067meningioma\u304c\u793a\u5506\u3055\u308c\u307e\u3059\uff08\u5de6\uff1aEMA\u67d3\u8272 x200x)\u3002\u816b\u760d\u306e\u4e00\u90e8\u3067collagen fiber\u306e\u591a\u3044\u7d44\u7e54\u306b\u79fb\u884c\u3057\u3001\u6838\u306e\u6d88\u5931\u3092\u4f34\u3046\u58ca\u6b7b\u6027\u5909\u5316\u3092\u793a\u3059\u90e8\u4f4d\u304c\u898b\u3089\u308c\u307e\u3059\u3002<br \/>\n<a href=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/atypicalmeninsy6.png\" rel=\"attachment wp-att-8759\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-8759 size-medium\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/atypicalmeninsy5-300x225.png\" alt=\"atypicalmeninsy5\" width=\"300\" height=\"225\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/atypicalmeninsy5-300x225.png 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/atypicalmeninsy5-550x413.png 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/atypicalmeninsy5.png 720w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-8760 size-medium\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/atypicalmeninsy6-300x225.png\" alt=\"\" width=\"300\" height=\"225\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/atypicalmeninsy6-300x225.png 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/atypicalmeninsy6-550x413.png 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/atypicalmeninsy6.png 720w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>\u816b\u760d\u306e\u5468\u8fba\u90e8\u306b<strong><span style=\"color: #000080;\">onion bulb<\/span><\/strong>\u69cb\u9020 (\u2192)\u304c\u898b\u3089\u308c\u3001meningioma\u306e\u8a3a\u65ad\u304c\u59a5\u5f53\u3067\u3059\uff08\u5de6\uff09\u3002\u7d30\u80de\u6838\u306e\u7570\u578b\u6027\u304c\u3042\u308aMIB-1 index\u304c10%\u3068\u9ad8\u5024\u3067\u3042\u308a\uff08\u53f3\uff09\u3001atypical meningioma\u3067\u3059\u3002<\/p>\n<h4><strong>necrosis \u58ca\u6b7b\u30fbatypical meningioma WHO grade 2 \u975e\u5b9a\u578b\u9ac4\u819c\u816b\u00a0<\/strong><\/h4>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/meningiomanecrosis.jpg\" rel=\"attachment wp-att-8780\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-8780\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/meningiomanecrosis-300x282.jpg\" alt=\"meningiomanecrosis\" width=\"300\" height=\"282\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/meningiomanecrosis-300x282.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/meningiomanecrosis-768x723.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/meningiomanecrosis-550x518.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/meningiomanecrosis.jpg 850w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><br \/>\nWHO grade 2 atypical meningioma (MIB-1 15%)\u306b\u8a8d\u3081\u3089\u308c\u305f\u58ca\u6b7b\u50cf\u3067\u3059\u3002\u3053\u306e\u75c5\u7406\u90e8\u5206\u50cf\u304b\u3089\u306fgrade 2\u3067\u3059\u304c\uff0cMIB-1\u3082\u975e\u5e38\u306b\u9ad8\u7387\u3067\u3059\u3002\u3055\u3089\u306b\uff0c\u591a\u5c11\u306a\u308a\u3068\u3082\u6838\u7570\u578b\u304c\u307f\u3089\u308c\u308b\u3068grade 3\u306eanaplastic meningioma\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<h4><strong>anaplastic meningioma WHO grade 3\u3000\u9000\u5f62\u6210\u6027\u9ac4\u819c\u7a2e<\/strong><\/h4>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/anaplasticmeningint.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-9541 size-medium\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/anaplasticmeningint-300x265.jpg\" alt=\"anaplasticmeningint\" width=\"300\" height=\"265\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/anaplasticmeningint-300x265.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/anaplasticmeningint-768x677.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/anaplasticmeningint-550x485.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/anaplasticmeningint.jpg 787w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><br \/>\n\u6975\u3081\u3066\u9ad8\u3044\u7d30\u80de\u5bc6\u5ea6\u3067\u3059\u3002MIB-1\u306f20%\u306b\u9054\u3057\u307e\u3059\u3002\u8089\u816b sarcoma \u3068\u3057\u3066\u306e\u6027\u8cea\u3092\u6709\u3057\uff0c\u982d\u84cb\u5185\u3067\u8ee2\u79fb\u3057\uff0c\u6458\u51fa\u3057\u3066\u3082\u591a\u767a\u518d\u767a\u3057\u307e\u3059\u3002\u653e\u5c04\u7dda\u5916\u79d1\u6cbb\u7642\u3067\u3082\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n<h4><strong>chordoid meningioma WHO grade 2 \u810a\u7d22\u816b\u69d8\u9ac4\u819c\u816b<\/strong><\/h4>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/04\/chordoidmening11.jpg\" rel=\"attachment wp-att-6333\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-6333 size-medium\" title=\"chordoidmening1\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/04\/chordoidmening11-300x289.jpg\" alt=\"\" width=\"300\" height=\"289\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/04\/chordoidmening11-300x289.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/04\/chordoidmening11-550x529.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/04\/chordoidmening11.jpg 850w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/04\/chordoidmening2.jpg\" rel=\"attachment wp-att-6334\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-6334 size-medium\" title=\"chordoidmening2\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/04\/chordoidmening2-300x276.jpg\" alt=\"\" width=\"300\" height=\"276\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/04\/chordoidmening2-300x276.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/04\/chordoidmening2-550x506.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/04\/chordoidmening2.jpg 850w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>\u3053\u306e\u4f8b\u306f\u978d\u7d50\u7bc0\u306b\u767a\u751f\u3057\u305f\u9ac4\u819c\u816b\u3067\uff0cT2\u5f37\u8abf\u753b\u50cf\u3067\u306f\u9ad8\u4fe1\u53f7\u304c\u76ee\u7acb\u3061\u307e\u3057\u305f\u304c\u9aa8\u6d78\u6f64\u306f\u306a\u304f\uff0c\u4e00\u822c\u7684\u306agrade 1 meningioma\u3068\u306e\u9451\u5225\u306f\u3067\u304d\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u7c98\u6db2\u3092\u542b\u3080\u816b\u760d\u3067\u3001\u597d\u9178\u6027\u306e\u80de\u4f53\u3092\u6301\u3064\u7d21\u9318\u5f62\u306a\u3044\u3057\u985e\u5186\u5f62\u6838\u306e\u7d30\u80de\u304c<span style=\"color: #000080;\"><strong>myxoid \/ \u00a0chordoid matrix<\/strong><\/span>\u306b\u6d6e\u904a\u3057\u3066\u3044\u308b\u6240\u898b\u3067\u3059\u3002\u816b\u760d\u7d30\u80de\u304c\u56fa\u307e\u308b\u90e8\u5206\u306f\u5178\u578b\u7684\u306a\u9ac4\u819c\u816b\u306e\u7279\u5fb4\u3092\u3088\u304f\u8868\u3059\u7d44\u7e54\u69cb\u9020\u3067\u3059\u3002\u80de\u4f53\u5185\u306b\u306f\u7a7a\u80de\u5909\u6027 vacuolated cells \u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002MIB-1 5%, EMA (+), Cam5.2 (-)\u3002\u73cd\u3057\u3044\u30bf\u30a4\u30d7\u3067\uff0c\u6982\u3057\u3066\u5927\u304d\u306a\u9ac4\u819c\u816b\u3068\u3057\u3066\u30c6\u30f3\u30c8\u4e0a\u306b\u767a\u898b\u3055\u308c\uff0c\u624b\u8853\u5f8c\u306e\u518d\u767a\u7387\u306f\u9ad8\u3044\u306e\u3067\u30b0\u30ec\u30fc\u30c92\u3068\u3055\u308c\u307e\u3059\u3002Wang\u306f30\u4f8b\u4e2d\u306e5\u4f8b\u306b\u518d\u767a\u3092\u898b\u305f\u3068\u3057\u3066\u3044\u307e\u3059\u304b\u3089\u5168\u6458\u51fa\u3067\u304d\u308c\u3070\u305d\u308c\u307b\u3069\u9ad8\u3044\u518d\u767a\u5272\u5408\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<br \/>\nCastleman&#8217;s disease\u3092\u306f\u3058\u3081hematological conditions \/ diseases\u3068\u306e\u5408\u4f75\u3084\u5c0f\u5150\u4f8b\u4f8b\u304c\u591a\u3044\u3068\u3055\u308c\u307e\u3057\u305f\u304c\uff0c\u5b9f\u969b\u306b\u306f\u7279\u767a\u4f8b\uff0c\u5b64\u767a\u4f8b\u304c\u591a\u3044\u3067\u3059\u3002<\/p>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/soloillust3.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-thumbnail wp-image-9449\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/soloillust3-200x200.jpg\" alt=\"soloillust3\" width=\"200\" height=\"200\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/soloillust3-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2016\/04\/soloillust3-144x144.jpg 144w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<h4>\u9ac4\u819c\u816b\u306emethylation profile\u3068\u4e88\u5f8c<\/h4>\n<p class=\"c-article-title\" data-test=\"article-title\">Choudhury A: Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities. Nat Genet 2022<br \/>\n565\u4f8b\u306e\u9ac4\u819c\u816b\u3067DNA\u30e1\u30c1\u30ec\u30fc\u30b7\u30e7\u30f3\u304c\u8abf\u3079\u3089\u308c\u307e\u3057\u305f\u3002Merlin\u907a\u4f1d\u5b50\u306b\u7570\u5e38\u304c\u306a\u304b\u3063\u305f\u4f8b\u304c34%\u3042\u308a\uff0c\u305d\u306e\u7fa4\u306e\u4e88\u5f8c\u304c\u6700\u3082\u3088\u304b\u3063\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002\u9006\u306b\uff0c<span style=\"color: #000080;\"><strong><em>NF2<\/em>\/Merlin\u907a\u4f1d\u5b50\u7570\u5e38\u304c\u3042\u308b\u4f8b\u306f\u4e88\u5f8c\u304c\u60aa\u3044\u53ef\u80fd\u6027<\/strong><\/span>\u304c\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002immune infiltration, HLA expression, lymphatic vessels\u304c\u3042\u308b\u7fa4\u3067\u306f\u4e2d\u9593\u4e88\u5f8c\u3067\u3057\u305f\u3002\u65e7\u6765\u306e\u3054\u3068\u304f\u3084\u306f\u308a\u4e88\u5f8c\u304c\u60aa\u3044\u7fa4 (28%)\u3067\u306fhypermitoses\u304c\u307f\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n<h4><span style=\"color: #333333;\">\u9ac4\u819c\u816b\u306e\u767a\u751f\u539f\u56e0<\/span><\/h4>\n<p>Clark VE, et al.: Recurrent somatic mutations in\u00a0<em>POLR2A<\/em>\u00a0define a distinct subset of meningiomas.\u00a0<em>Nature Genetics<\/em>\u00a048, 2016<br \/>\nYale\u5927\u5b66\u304b\u3089\u306e\u5831\u544a\u3067\u3059\u3002RNA polymerase II\u3068\u3044\u3046\u3068\u3066\u3082\u91cd\u8981\u306a\u907a\u4f1d\u5b50\u306b\u7570\u5e38\u304c\u3042\u3063\u3066\u9ac4\u819c\u816b\u304c\u767a\u751f\u3059\u308b\u3068\u3044\u3046\uff0c\u3042\u308b\u610f\u5473\u885d\u6483\u7684\u306a\u767a\u8868\u3067\u3059\u3002775\u4f8b\u306e\u9ac4\u819c\u816b\u3092\u8abf\u3079\u3066\uff0cRNA polymerase II\u3092\u30b3\u30fc\u30c9\u3059\u308b<strong>\u00a0<span style=\"color: #000080;\"><i>POLR2A<\/i><\/span><\/strong>\u306b<i>\uff0c<\/i>recurrent somatic p.Gln403Lys or p.Leu438_His439del mutations\u3092\u767a\u898b\u3057\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u304c\u30cf\u30a4\u30b8\u30e3\u30c3\u30af\u3055\u308c\u308b\u3053\u3068\u3067\uff0c\u9ac4\u819c\u306e\u767a\u751f\u306b\u95a2\u308f\u308b<i>WNT6<\/i>and\u00a0<i>ZIC1<\/i>\/<i>ZIC4<\/i>\u306e\u5236\u5fa1\u7570\u5e38\u304c\u751f\u3058\u307e\u3059\u3002\u65e2\u77e5\u306e<span style=\"color: #000080;\"><strong><i>NF2<\/i>,\u00a0<i>SMARCB1, TRAF7<\/i>,\u00a0<i>KLF4<\/i>,\u00a0<i>AKT1<\/i>,\u00a0<i>PIK3CA<\/i>,\u00a0<i>SMO<\/i><\/strong><\/span>\u306b\u52a0\u3048\u3066\uff0c<span style=\"color: #000080;\"><strong><i>AKT3<\/i>,\u00a0<i>PIK3R1<\/i>,\u00a0<i>PRKAR1A<\/i>,\u00a0<i>SUFU<\/i><\/strong><\/span>\u306b\u3082\u5909\u7570\u304c\u8a8d\u3081\u3089\u308c\u308b\u3068\u306e\u5831\u544a\u3067\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5927\u5207\u306a\u3053\u3068 \u81e8\u5e8a\u533b\u306f\uff0c\u307e\u305a\u9ac4\u819c\u816b\u304c\u30b0\u30ec\u30fc\u30c9\uff11\u304b\uff12\u304b\u306b\u6ce8\u76ee\u3057\u307e\u3059 \u30b0\u30ec\u30fc\u30c9\uff11\u3067\u3042\u308c\u3070\uff0cMIB-1\u67d3\u8272\u7387\u3092\u307f\u307e\u3059\uff0cMIB\u304c5%\u3092\u8d85\u3048\u308b\u3068\u518d\u767a\u7387\u306f\u9ad8\u3044\u3067\u3059 \u624b\u8853\u521d\u898b\u3067\uff0c\u8133\u306b\u6d78\u6f64\u304c\u3042\u308c\u3070\u305d\u308c\u3067\u30b0\u30ec\u30fc\u30c9\uff12\u3067\u3059 \u75c5\u7406\u8a3a\u65ad\u3067\u30b0\u30ec\u30fc\u30c9\uff12 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-8647","post","type-post","status-publish","format-standard","hentry","category-pathocase"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/8647","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/comments?post=8647"}],"version-history":[{"count":32,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/8647\/revisions"}],"predecessor-version":[{"id":22755,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/8647\/revisions\/22755"}],"wp:attachment":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/media?parent=8647"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/categories?post=8647"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/tags?post=8647"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}