{"id":8097,"date":"2015-09-22T10:09:02","date_gmt":"2015-09-22T01:09:02","guid":{"rendered":"\/sawamura\/?p=8097"},"modified":"2024-07-30T12:15:43","modified_gmt":"2024-07-30T03:15:43","slug":"nf-2","status":"publish","type":"post","link":"https:\/\/plaza.umin.ac.jp\/sawamura\/braintumors\/nf-2\/","title":{"rendered":"\u795e\u7d4c\u7dda\u7dad\u816b\u75c7 2\u578b  NF-2"},"content":{"rendered":"<div class=\"setumei\">\n<h5>neurofibromatosis \u795e\u7d4c\u7dda\u7dad\u816b\u75c7<\/h5>\n<ul>\n<li>\u89aa\u304b\u3089\u5b50\u306b\u907a\u4f1d\uff08\u5e38\u67d3\u8272\u4f53\u512a\u6027\u907a\u4f1d\u75be\u60a3\uff09\u3059\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u304c\uff0c\u534a\u5206\u4ee5\u4e0a\u306e\u60a3\u8005\u3055\u3093\u306f\u907a\u4f1d\u3067\u306f\u3042\u308a\u307e\u305b\u3093<\/li>\n<li>3\u3064\u306e\u578b\u304c\u3042\u308a\uff0c1\u578b\u304c96\uff05\uff0c<span style=\"color: #000080;\"><strong>2\u578b\u304c3\uff05<\/strong><\/span>\uff0c<span style=\"color: #000080;\"><strong>schwannomatosis (SWN) \u304c1%<\/strong><\/span>\u672a\u6e80\u3067\u3059<\/li>\n<li><strong><span class=\"setumei\" style=\"color: #ff0000;\"><span style=\"color: #000080;\"><a style=\"color: #000080;\" href=\"\/sawamura\/braintumors\/nf-1\/\">\uff11\u578b (NF-1 \u30a8\u30cc\u30a8\u30d5\u30ef\u30f3)\u00a0<\/a><\/span><span style=\"color: #000000;\">\u306f\uff0c<\/span><span style=\"color: #000080;\">\u5168\u8eab\u306e\u76ae\u819a\u306b\u305f\u304f\u3055\u3093\u306e\u5c0f\u3055\u306a\u816b\u760d\uff08\u672b\u68a2\u795e\u7d4c\u7dda\u7dad\u816b\uff09\u3068\u8336\u8272\u306e\u30b7\u30df\u306e\u3088\u3046\u306a\u3082\u306e\uff08\u30ab\u30d5\u30a7\u30aa\u30ec\u6591\uff09<\/span><\/span><\/strong>\u304c\u3067\u304d\u308b\u75c5\u6c17\u3067\u3059<\/li>\n<li>\uff11\u578b NF-2 \u306f\u304b\u3064\u3066\u30d5\u30a9\u30f3\u30ec\u30c3\u30af\u30ea\u30f3\u30b0\u30fb\u30cf\u30a6\u30bc\u30f3\u6c0f\u75c5\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u307e\u3057\u305f<\/li>\n<li>\u7b2c17\u756a\u3081\u306e\u67d3\u8272\u4f5317q\u306b\u3042\u308bNF1\u3068\u3044\u3046\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3067neurofibromin\u3068\u3044\u3046\u86cb\u767d\u304c\u6b63\u5e38\u306b\u50cd\u304b\u306a\u304f\u306a\u3063\u3066\u8d77\u3053\u308b\u75c5\u6c17\u3067\u3059<\/li>\n<li><strong><span style=\"color: #ff0000;\">\uff12\u578b (NF-2 \u30a8\u30cc\u30a8\u30d5\u30c4\u30fc)<\/span><\/strong><strong><span style=\"color: #ff0000;\"><span style=\"color: #000000;\">\u00a0\u306f\uff0c<\/span><span style=\"color: #000080;\">\u8133\u795e\u7d4c\u3068\u810a\u9ac4\u795e\u7d4c\u306b\u795e\u7d4c\u9798\u816b\u3084\u9ac4\u819c\u816b<\/span><\/span><\/strong>\u304c\u305f\u304f\u3055\u3093\u3067\u304d\u308b\u75c5\u6c17\u3067\u3059<\/li>\n<li>\u7b2c22\u756a\u3081\u306e\u67d3\u8272\u4f5322q\u306b\u3042\u308bNF2\u3068\u3044\u3046\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3067merlin\u3068\u3044\u3046\u86cb\u767d\u304c\u6b63\u5e38\u306b\u50cd\u304b\u306a\u304f\u306a\u3063\u3066\u8d77\u3053\u308b\u75c5\u6c17\u3067\u3059<\/li>\n<li>\u4e21\u65b9\u3068\u3082\u306b\u3042\u308b\u7a0b\u5ea6\u75c5\u6c17\u304c\u91cd\u3044\u3068\u533b\u7642\u8cbb\u304c\u88dc\u52a9\u3055\u308c\u307e\u3059<\/li>\n<li>\uff11\u578b\u306e\u60a3\u8005\u3055\u3093\uff08\u6570\u5343\u4eba\u306b\u4e00\u4eba\uff09\u306e\u65b9\u304c\uff12\u578b\uff08\u6570\u4e07\u4eba\u306b\u4e00\u4eba\uff09\u3088\u308a\u304b\u306a\u308a\u591a\u3044\u3067\u3059<\/li>\n<li>\uff11\u578b\u3067\u6cbb\u7642\u3057\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u8133\u816b\u760d\u306f\u3081\u305a\u3089\u3057\u3044\u3067\u3059\u304c\uff0c\uff12\u578b\u306e\u8133\u816b\u760d\u306f\u6cbb\u7642\u3092\u5fc5\u8981\u3068\u3059\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059<\/li>\n<li><strong><span style=\"color: #ff0000;\">\u3044\u305a\u308c\u3082\u826f\u6027\u816b\u760d\u3067\u3059<\/span><\/strong><span style=\"color: #000000;\">\u304b\u3089\u6cbb\u7642\u3092\u3042\u308f\u3066\u308b\u5fc5\u8981\u306f\u3042\u308a\u307e\u305b\u3093<\/span><\/li>\n<li>\u73fe\u4ee3\u3067\u306f\u6cbb\u7642\u6cd5\u304c\u767a\u9054\u3057\u3066\u3044\u308b\u306e\u3067\u3069\u306e\u3088\u3046\u306a\u8133\u810a\u9ac4\u816b\u760d\u306b\u306a\u3063\u3066\u3082\u6cbb\u7642\u6cd5\u306f\u3042\u308a\u307e\u3059<\/li>\n<li><strong><span style=\"color: #000080;\">\u305f\u304f\u3055\u3093\u816b\u760d\u304c\u3042\u308b\u3068\u3044\u3063\u3066\u3082\u6cbb\u7642\u3092\u3057\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u304b\u3069\u3046\u304b\u304b\u306a\u308a\u614e\u91cd\u306b\u8003\u3048\u308b\u3053\u3068\u304c\u5927\u5207\u3067\u3059<\/span><\/strong><\/li>\n<li>\u3060\u3044\u305f\u3044\u304c\u826f\u6027\u816b\u760d\u306a\u306e\u3067\u4f55\u3082\u3057\u306a\u3044\u3067\u304a\u3044\u3066\u3082\u75c7\u72b6\u304c\u60aa\u304f\u306a\u3089\u306a\u3044\u3053\u3068\u3082\u3042\u308b\u306e\u3067\u3059<\/li>\n<li>2\u578b\u306b\u306f\u305f\u304f\u3055\u3093\u306e\u8133\u810a\u9ac4\u816b\u760d\u304c\u3067\u304d\u308b\u306e\u3067\u3059\u304c\uff0c\u305d\u306e\u3046\u3061\u306e<span style=\"color: #000080;\"><strong>\u3069\u306e\u816b\u760d\u304c\u5927\u304d\u304f\u306a\u308b\u304b\u306f\u4e88\u6e2c\u304c\u3067\u304d\u307e\u305b\u3093<\/strong><\/span><\/li>\n<li>\uff12\u578b\u306b\u3067\u304d\u308b\u4e21\u5074\u306e\u8074\u795e\u7d4c\u816b\u760d\u306e\u6cbb\u7642\u306f\u3068\u3066\u3082\u96e3\u3057\u3044\u306e\u3067\uff0c\u666e\u901a\u306e\u8133\u5916\u79d1\u533b\u306e\u5148\u751f\u306b\u306f\u6cbb\u7642\u3067\u304d\u307e\u305b\u3093\u304b\u3089\u305d\u308c\u306b\u8a73\u3057\u3044\u5c02\u9580\u5bb6\u306b\u76f8\u8ac7\u3057\u307e\u3057\u3087\u3046<\/li>\n<li><span style=\"color: #000080;\"><strong>\u5931\u660e\u3059\u308b\u5371\u967a\u306f1\u578b\u306b\u30822\u578b\u306b\u3082\u3042\u308a\u307e\u3059<\/strong><\/span>\u304b\u3089\uff0c\u305d\u308c\u306b\u6c17\u3065\u304b\u306a\u3044\u533b\u5e2b\u306b\u306f\u3053\u306e\u75c5\u6c17\u3092\u307f\u308b\u529b\u91cf\u306f\u3042\u308a\u307e\u305b\u3093<\/li>\n<li>NF-2\u306e\u6cbb\u7642\u306b\u30d9\u30d0\u30b7\u30ba\u30de\u30d6\uff08\u30a2\u30d0\u30b9\u30c1\u30f3\uff09\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u52b9\u679c\u306f\u9650\u3089\u308c\u3066\u3044\u307e\u3059<\/li>\n<\/ul>\n<hr \/>\n<h5><span style=\"color: #000080;\"><span class=\"style3\">\u795e\u7d4c\u7dda\u7dad\u816b\u75c72\u578b\u306b\u306f\uff0c<span style=\"color: #ff0000;\">\u533b\u7642\u8cbb<\/span><\/span><strong><span style=\"color: #ff0000;\">\u306e\u88dc\u52a9\u304c\u3042\u308a\u307e\u3059<\/span><\/strong><\/span><\/h5>\n<h5><span style=\"color: #000080;\"><a style=\"color: #000080;\" href=\"\/sawamura\/braintumors\/nf-1\/\">\u795e\u7d4c\u7dda\u7dad\u816b\u75c71\u578b NF-1\u306b\u3064\u3044\u3066\u306f\u4ed6\u306e\u30da\u30fc\u30b8\u306b\u66f8\u3044\u3066\u3042\u308b\u306e\u3067\uff0c\u3053\u3053\u3092\u30af\u30ea\u30c3\u30af<\/a><\/span><\/h5>\n<h1>\u795e\u7d4c\u7dda\u7dad\u816b\u75c7\uff12\u578b<\/h1>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-12019\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2015\/09\/nf2it1-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2015\/09\/nf2it1-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2015\/09\/nf2it1-144x144.jpg 144w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><br \/>\n\u3068\u3066\u3082\u6709\u540d\u306a\u306e\u304c<span style=\"color: #000080;\"><strong>\u4e21\u5074\u306e<a style=\"color: #000080;\" href=\"\/sawamura\/braintumors\/acoustictumor\/\">\u8074\u795e\u7d4c\u816b\u760d<\/a><\/strong><\/span>\u3067\uff0c\u8a3a\u65ad\u57fa\u6e96\u306b\u5165\u3063\u3066\u307e\u3059<\/p>\n<hr \/>\n<ul>\n<li>\u8133\u3068\u810a\u9ac4\u306e\u3055\u307e\u3056\u307e\u306a\u795e\u7d4c\u3084\u9ac4\u819c\u306b\u3069\u3053\u306b\u3067\u3082\u816b\u760d\u304c\u3067\u304d\u307e\u3059<\/li>\n<li>\u3067\u3059\u304b\u3089\uff0c\u767a\u75c7\u3059\u308b\u306e\u306f<span style=\"color: #000080;\"><strong>\u7247\u8033\u306e\u805e\u3053\u3048\u304c\u60aa\u3044\u3068\u3044\u3046\u75c7\u72b6<\/strong><\/span>\u304b\u3089\u3067\u3059\uff0c\u6b21\u3044\u3067\uff0c\u8033\u9cf4\u308a\uff0c\u30d5\u30e9\u30c4\u30ad\uff0c\u982d\u75db\u3067\u3059<\/li>\n<li>\u8074\u795e\u7d4c\u4ee5\u5916\u306e\u8133\u816b\u760d\u306f50%\u307b\u3069\u306e\u60a3\u8005\u3055\u3093\u306b\uff0c\u810a\u67f1\u7ba1\u5185\u816b\u760d\u306f50\uff05\u304f\u3089\u3044\u306e\u60a3\u8005\u3055\u3093\u3067\u767a\u751f\u3057\u307e\u3059\u3002<\/li>\n<li>\u4e00\u756a\u591a\u3044\u306e\u304c<span style=\"color: #000080;\"><strong>\u795e\u7d4c\u9798\u816b<\/strong><\/span>\u3067\uff0c\u8074\u795e\u7d4c\uff08\u524d\u5ead\u795e\u7d4c\uff09\uff0c\u4e09\u53c9\u795e\u7d4c\u306a\u3069\u306a\u3069\u306e\u8133\u795e\u7d4c\u3084\uff0c\u810a\u9ac4\u306e\u795e\u7d4c\u306b\u3082\u3067\u304d\u307e\u3059<\/li>\n<li>\u4e8c\u756a\u76ee\u306f<span style=\"color: #000080;\"><strong><a style=\"color: #000080;\" href=\"\/sawamura\/braintumors\/meningioma\/\">\u9ac4\u819c\u816b<\/a><\/strong><\/span>\u3067\uff0c\u8133\u3084\u810a\u9ac4\u3092\u88ab\u3063\u3066\u3044\u308b\u9ac4\u819c\u306b\u3067\u304d\u307e\u3059\u304c\uff0c\u982d\u306e\u4e2d\u3067\u3082\u810a\u67f1\u7ba1\u306e\u4e2d\u3067\u3082\u3069\u3053\u306b\u3067\u3082\u767a\u751f\u3057\u307e\u3059<\/li>\n<li>\u9ac4\u819c\u816b\u75c7 meningiomatosis \u3068\u3044\u3063\u3066\u591a\u6570\u306e\u9ac4\u819c\u816b\u304c\u3044\u305f\u308b\u3068\u3053\u308d\u306b\u3067\u304d\u308b\u3068\u3044\u3046\u306e\u3082\u3042\u308a\u307e\u3059<\/li>\n<li>\u307b\u3093\u306e\u4e00\u90e8\u306e\u60a3\u8005\u3055\u3093\u3067\uff0c\u810a\u9ac4\u306e\u4e2d\u306b\u306f<span style=\"color: #000080;\"><strong><a style=\"color: #000080;\" title=\"\u4e0a\u8863\u816b\" href=\"\/sawamura\/pediattumor\/ependy\/\">\u4e0a\u8863\u816b ependymoma<\/a><\/strong><\/span>\u00a0\u304c\u591a\u767a\u3057\u307e\u3059<\/li>\n<li>\u3053\u308c\u3089\u306e\u816b\u760d\u306f\u591a\u767a\u3059\u308b\uff08\u305f\u304f\u3055\u3093\u3044\u3063\u307a\u3093\u306b\u898b\u3064\u304b\u308b\uff09\u306e\u304c\u7279\u5fb4\u3067\u3059<\/li>\n<li>\u6cbb\u7642\u306f\uff0c\u5927\u304d\u304f\u306a\u3063\u3066\u304f\u308b\u3042\u308b\u3044\u306f\u75c7\u72b6\u3092\u51fa\u3057\u3066\u304f\u308b\u3082\u306e\u3060\u3051\u306b\u3057\u307e\u3059<\/li>\n<li>\u7121\u75c7\u72b6\u306e\u816b\u760d\u306b\u6cbb\u7642\u3092\u3059\u308b\u3053\u3068\u306f\u6ce8\u610f\u6df1\u304f\u3057\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093<\/li>\n<li><span style=\"color: #000080;\"><strong>NF-2\u3067\u795e\u7d4c\u9798\u816b\u304c\u591a\u767a\u3059\u308b\u3068\uff0c\u9ac4\u6db2\u5438\u53ce\u969c\u5bb3\u3068\u306a\u308a\u8133\u5727\u304c\u9ad8\u304f\u306a\u3063\u3066\u6025\u901f\u306b\u5931\u660e\u3059\u308b<\/strong><\/span>\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u304b\uff0c\u8133\u5ba4\u304c\u5927\u304d\u304f\u306a\u304f\u3066\u30b9\u30ea\u30c3\u30c8\u578b\u8133\u5ba4\u3067\u3082\u8133\u8cea\u8179\u8154\u30b7\u30e3\u30f3\u30c8\u8853\u3092\u3057\u306a\u3044\u3068\u8996\u529b\u304c\u6551\u3048\u307e\u305b\u3093<\/li>\n<li>\u8033\u3082\u805e\u3053\u3048\u306a\u3044\u76ee\u3082\u898b\u3048\u306a\u3044\u3068\u3044\u3046\u4e8b\u614b\u306b\u306a\u308a\u307e\u3059<\/li>\n<li>\u3053\u308c\u3092\u77e5\u3089\u306a\u3044\u8133\u795e\u7d4c\u5916\u79d1\u533b\u306fNF-2\u3092\u8a3a\u308c\u307e\u305b\u3093<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h5>\u5408\u4f75\u3059\u308b\u816b\u760d\u306e\u8a73\u3057\u3044\u8aac\u660e\u306f\u5225\u306a\u30da\u30fc\u30b8\u306b\u66f8\u3044\u3066\u3042\u308a\u307e\u3059\u304b\u3089\u4ee5\u4e0b\u306e\u75c5\u540d\u3092\u30af\u30ea\u30c3\u30af\u3057\u3066\u4e0b\u3055\u3044\uff0c<span style=\"color: #000080;\"><a style=\"color: #000080;\" href=\"acoustictumor\/\">\u8074\u795e\u7d4c\u816b\u760d<\/a>\uff0c<a style=\"color: #000080;\" href=\"schwann\/\">\u305d\u306e\u4ed6\u306e\u795e\u7d4c\u9798\u816b<\/a>\uff0c<a style=\"color: #000080;\" href=\"meningioma.html\">\u9ac4\u819c\u816b<\/a><\/span><\/h5>\n<h4>\u5178\u578b\u7684\u306aNF-2\u306e\u60a3\u8005\u3055\u3093<\/h4>\n<p>\u4e2d\u5fc3\u3068\u306a\u308b\u306e\u306f\u795e\u7d4c\u9798\u816b\u3068\u9ac4\u819c\u816b\u3067\u3059\u3002\u4e0b\u306eMRI\u306f\u5178\u578b\u7684\u306a\u4e21\u5074\u8074\u795e\u7d4c\u816b\u760d\u3068\u547c\u3070\u308c\u308b\u753b\u50cf\u3067\u3059\u3002\u4e21\u5074\u306e\u5185\u8033\u9053\u304b\u3089\u816b\u760d\uff08\u9ed2\u304f\u898b\u3048\u308b\u3082\u306e\uff09\u304c\u7a81\u51fa\u3057\u3066\uff0c\u8133\u5e79\u90e8\u3092\u5f37\u304f\u5727\u8feb\u3057\u3066\u3044\u308b\u305f\u3081\u306b\u8133\u5e79\u90e8\u304c\u7e26\u9577\u306b\u5909\u5f62\u3057\u3066\u3057\u307e\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u69d8\u306b\u3072\u3069\u3044\u8133\u5e79\u90e8\u5909\u5f62\u3067\u3082\u307b\u3068\u3093\u3069\u75c7\u72b6\u304c\u7121\u304f\u66ae\u3089\u3057\u3066\u3044\u305f\u60a3\u8005\u3055\u3093\u3067\u3059\u3002\u8d64\u3044\u77e2\u5370\u3067\u793a\u3059\u306e\u306f\u6a2a\u9759\u8108\u6d1e\u5185\u304b\u3089\u7a81\u51fa\u3057\u3066\u3044\u308b\u9ac4\u819c\u816b\u3067\u3059\u3002<br \/>\n\u5c0f\u8133\u6a4b\u89d2\u90e8\u816b\u760d\u3042\u308b\u3044\u306f\u8074\u795e\u7d4c\u816b\u760d\u3068\u547c\u3070\u308c\u308b\u306e\u3067\uff0c\u5de6\u53f3\u306b\u4e00\u3064\u305a\u3064\u306e\u816b\u760d\u304b\u3068\u601d\u3063\u3066\u3057\u307e\u3046\u306e\u3067\u3059\u304c\uff0c\u5b9f\u306f\u9055\u3044\u307e\u3059\u3002\u3053\u306e\u60a3\u8005\u3055\u3093\u3067\u306f\uff0c\u53f3\u5074\u306e\u5c0f\u8133\u6a4b\u89d2\u90e8\u816b\u760d\u306f\uff0c\u4e09\u53c9\u795e\u7d4c\u9798\u816b\uff0c\u524d\u5ead\u795e\u7d4c\u9798\u816b\uff0c\u8778\u725b\u795e\u7d4c\u9798\u816b\uff0c\u9854\u9762\u795e\u7d4c\u9798\u816b\uff0c\u8ff7\u8d70\u795e\u7d4c\u9798\u816b\uff0c\u820c\u54bd\u795e\u7d4c\u9798\u816b\uff0c\u820c\u4e0b\u795e\u7d4c\u9798\u816b\u304c\u3059\u3079\u3066\u4e00\u584a\u306b\u306a\u3063\u305f\u3082\u306e\u3067\u3057\u305f\u3002\u3067\u3059\u304b\u3089\u3053\u306e\u5c0f\u8133\u6a4b\u89d2\u90e8\u816b\u760d\u3092\u6458\u51fa\u3057\u3088\u3046\u3068\u3059\u308c\u3070\uff0c\u4e0a\u306b\u66f8\u3044\u305f\u795e\u7d4c\u306e\u9ebb\u75fa\u306f\u624b\u8853\u5408\u4f75\u75c7\u3068\u3057\u3066\u5168\u90e8\u51fa\u73fe\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/07\/neurofibromatosis\/nf2-1.png\"><img loading=\"lazy\" decoding=\"async\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/07\/neurofibromatosis\/nf2-1.png\" alt=\"\" width=\"458\" height=\"256\" \/><\/a><\/p>\n<p>\u8133\u3068\u8170\u90e8\u306e\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u5897\u5f37MRI\u3067\u3059\u3002\u816b\u760d\u306f\u767d\u304f\u898b\u3048\u308b\u3088\u3046\u306b\u3057\u3066\u3042\u308a\u307e\u3059\u3002\u9ec4\u8272\u306e\u77e2\u5370\u3067\u793a\u3057\u305f\u4ee5\u5916\u306b\u3082\u7121\u6570\u306e\u795e\u7d4c\u9798\u816b\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/07\/neurofibromatosis\/nf2-2.png\"><img loading=\"lazy\" decoding=\"async\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/07\/neurofibromatosis\/nf2-2.png\" alt=\"\" width=\"459\" height=\"378\" \/><\/a><\/p>\n<h4>NF-2\u306e\u591a\u767a\u6027\u9ac4\u819c\u816b<\/h4>\n<p style=\"text-align: left;\"><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/nf2it.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-4402\" title=\"nf2it\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/nf2it.jpg\" alt=\"\" width=\"690\" height=\"259\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/nf2it.jpg 690w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/nf2it-300x112.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/nf2it-550x206.jpg 550w\" sizes=\"auto, (max-width: 690px) 100vw, 690px\" \/><\/a>\u8d64\u306e\u77e2\u5370\u304c\uff0c\u4e21\u5074\u306e\u8074\u795e\u7d4c\u816b\u760d\u3067\u3059\u3002\u9ec4\u8272\u306e\u77e2\u5370\u306f\uff0c \u591a\u767a\u6027\u306e\u9ac4\u819c\u816b\u3067\u3059\u3002\u8776\u5f62\u9aa8\u7e01\u9ac4\u819c\u816b\uff0c\u7a79\u9686\u90e8\u9ac4\u819c\u816b\uff0c\u5927\u8133\u938c\u9ac4\u819c\u816b\uff0c\u5927\u8133\u938c\u30c6\u30f3\u30c8\u63a5\u5408\u90e8\u9ac4\u819c\u816b\u306a\u3069\u3044\u3063\u3071\u3044\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306f\u57fa\u672c\u7684\u306b\u7d4c\u904e\u89b3\u5bdf\u3057\u307e\u3059\u304c\uff0c\u3068\u3066\u3082\u76ee\u7acb\u3063\u3066\u5927\u304d\u304f\u306a\u308b\u3082\u306e\u304c\u3042\u308c\u3070\u6458\u51fa\u3057\u307e\u3059\u3002\u6458\u51fa\u306b\u306f\u6ce8\u610f\u304c\u5fc5\u8981\u3067\uff0c\u8fd1\u3044\u5c06\u6765\u307e\u305f\u624b\u8853\u306b\u306a\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u306e\u3067\uff0c\u6b21\u56de\u306e\u624b\u8853\u3082\u3067\u304d\u308b\u3088\u3046\u306b\u5de5\u592b\u3057\u3066\u958b\u982d\u624b\u8853\u3057\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093\u3002\u3067\u306a\u3044\u3068\uff0c\u6b21\u306e\u624b\u8853\u3067\u306e\u5408\u4f75\u75c7\u304c\u5897\u3048\u307e\u3059\u3002\u307e\u305f\u4e00\u56de\u306e\u958b\u982d\u3067\u8fd1\u508d\u306e\u786c\u819c\u3084\u816b\u760d\u3092\u53ef\u80fd\u306a\u9650\u308a\u6458\u51fa\u3057\u3066\u3057\u307e\u3046\u3053\u3068\u3082\u5927\u5207\u3067\u3059\u3002\u3067\u306a\u3044\u3068\uff0c\u9650\u308a\u306a\u304f\u624b\u8853\u3092\u7e70\u308a\u8fd4\u3059\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<h5>NF-2\u3067\u8133\u816b\u760d\u3068\u9593\u9055\u3063\u3066\u3044\u306f\u3044\u3051\u306a\u3044\u5927\u8133\u306e\u75c5\u5909<\/h5>\n<ul>\n<li>NF-1\u3088\u308a\u305a\u3063\u3068\u5c11\u306a\u3044\u306e\u3067\u3059\u304c\uff0cNF-2\u3067\u3082\u5927\u8133\u306e\u75c5\u5909\u306f\u3057\u3070\u3057\u3070\u307f\u3089\u308c\u307e\u3059<\/li>\n<li>MRI\u3067\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u3088\u3046\u306b\u307f\u3048\u307e\u3059\u304c\u305d\u3046\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002T2\u5f37\u8abf\u753b\u50cf\u3067\u767d\u304f\u898b\u3048\u3066\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u9020\u5f71\u3055\u308c\u306a\u3044\u306e\u304c\u4e00\u822c\u7684\u306a\u7279\u5fb4\u3067\u3059<\/li>\n<li>\u5fae\u5c0f\u904e\u8aa4\u816b (microhamartoma)\u3068\u304b\u76ae\u8cea\u7570\u5f62\u6210 (cortical dysplasia)\u3068\u304b\u8840\u7ba1\u5468\u56f2\u8154\u62e1\u5927 (Virchow-Robin space enlargement)\u3068\u304b\u3044\u308f\u308c\u308b\u3082\u306e\u3067\u3059<\/li>\n<\/ul>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2015\/09\/nf2dysplasia3.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-11052\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2015\/09\/nf2dysplasia3-300x289.jpg\" alt=\"\" width=\"300\" height=\"289\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2015\/09\/nf2dysplasia3-300x289.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2015\/09\/nf2dysplasia3-550x529.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2015\/09\/nf2dysplasia3.jpg 709w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><br \/>\n\u5de6\u5074\u306e\u75c5\u5909\u306f\u304a\u305d\u3089\u304f\u76ae\u8cea\u7570\u5f62\u6210 cortical dysplasia\u3067\uff0c\u53f3\u4e2d\u592e\u5bc4\u308a\u306e\u75c5\u5909\u306fVirchow-Robin space\u306e\u62e1\u5927\u3067\u3059\u3002<\/p>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2015\/09\/nf2dysplasia2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-11053\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2015\/09\/nf2dysplasia2-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2015\/09\/nf2dysplasia2-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2015\/09\/nf2dysplasia2-144x144.jpg 144w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/a><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2015\/09\/nf2dysplasia1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-11054\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2015\/09\/nf2dysplasia1-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2015\/09\/nf2dysplasia1-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2015\/09\/nf2dysplasia1-144x144.jpg 144w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/a><br \/>\n\u75c5\u7406\u306f\u3068\u308c\u306a\u3044\u306e\u3067\u78ba\u5b9a\u3067\u304d\u307e\u305b\u3093\u304c\uff0c\u304a\u305d\u3089\u304f\u5fae\u5c0f\u904e\u8aa4\u816b microhamartoma\u306a\u306e\u3067\u3057\u3087\u3046<\/p>\n<hr \/>\n<h4><span style=\"color: #000080;\">NF-1\u3068NF-2\u306e\u6c34\u982d\u75c7<\/span><\/h4>\n<ul>\n<li>\u591a\u304f\u306e\u5834\u5408\u306f\u904e\u5f62\u6210\u6027\u30b0\u30ea\u30aa\u30fc\u30b7\u30b9\u3067\uff0c<strong><span style=\"color: #000080;\">\u4e2d\u8133\u6c34\u9053\u3068\u3044\u3046\u9ac4\u6db2\u306e\u6d41\u308c\u9053\u304c\u3064\u307e\u3063\u3066\u6c34\u982d\u75c7\uff08\u4e2d\u8133\u6c34\u9053\u9589\u585e\uff09<\/span><\/strong>\u306b\u306a\u308a\u307e\u3059\u3002\u3053\u308c\u306f\u6025\u306b\u75c7\u72b6\u3092\u51fa\u3059\u3053\u3068\u304c\u306a\u304f\u3066\u6162\u6027\u306e\u982d\u75db\u3068\u304b\u3092\u751f\u3058\u308b\u505c\u6b62\u6027\u6c34\u982d\u75c7\u306b\u306a\u308a\u3084\u3059\u3044\u3067\u3059\u3002\u6cbb\u7642\u306f\uff0c\u5185\u8996\u93e1\u3092\u4f7f\u3063\u3066\u9ac4\u6db2\u306e\u901a\u308a\u9053\u3092\u3042\u3051\u308b\u7b2c\uff13\u8133\u5ba4\u958b\u7a93\u8853\u3068\u3044\u3046\u306e\u3092\u3057\u305f\u3089\u6cbb\u308a\u307e\u3059\u3002<\/li>\n<li>\u3082\u3046\u4e00\u3064\uff0c<strong><span style=\"color: #ff0000;\">NF-2\u306b\u751f\u3058\u308b\u73fe\u8c61\u3067\u3059\u304c\uff0c\u8133\u816b\u760d\u304c\u591a\u767a\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u9ac4\u6db2\u5438\u53ce\u969c\u5bb3\u304c\u751f\u3058\u3066\uff0c\u4ea4\u901a\u6027\u6c34\u982d\u75c7\u306b\u306a\u308a\u307e\u3059<\/span><\/strong>\u3002\u3053\u306e\u5834\u5408\u306b\uff0c\u7279\u306b\u6c17\u3092\u4ed8\u3051\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u306e\u304c\u8133\u5ba4\u304c\u5927\u304d\u304f\u306a\u3089\u306a\u3044 (slit ventricle) \u306e\u3067\uff0c\u6c34\u982d\u75c7\u3067\u306f\u306a\u3044\u3068\u601d\u3063\u3066\u3057\u307e\u3046\u3053\u3068\u3067\u3059\u3002\u773c\u5e95\u691c\u67fb\u3092\u3059\u308b\u3068\uff0c\u3046\u3063\u8840\u4e73\u982d\u304b\u3042\u308b\u3044\u306f\u4e73\u982d\u840e\u7e2e\u306e\u6240\u898b\u304c\u3042\u308a\u307e\u3059\u3002\u6025\u3044\u3067\uff0c\u8133\u5ba4\u8179\u8154\u30b7\u30e3\u30f3\u30c8\u3092\u3057\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093\u304c\uff0c\u5b9a\u4f4d\u8133\u624b\u8853\u3067\u3057\u304b\u8133\u5ba4\u7aef\u3092\u523a\u5165\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u305b\u3093\u3002 \u305d\u3057\u306a\u3044\u3068\u5931\u660e\u3057\u307e\u3059\u3002<\/li>\n<\/ul>\n<h4>\u304a\u3068\u306a\u3057\u3044\u30bf\u30a4\u30d7\u3068\u9032\u884c\u304c\u65e9\u3044\u30bf\u30a4\u30d7\uff08\u534a\u3005\u304f\u3089\u3044\uff09<\/h4>\n<ol>\n<li><strong><span style=\"color: #000080;\">\u00a0Gardner type<\/span><\/strong>\uff1a\u4e21\u5074\u306e\u524d\u5ead\u795e\u7d4c\u9798\u816b\u3060\u3051\u3067\u3086\u3063\u304f\u308a\u9032\u884c\u3059\u308b\u3082\u306e\u3067\u3059<\/li>\n<li><strong><span style=\"color: #000080;\">\u00a0Wishart type<\/span><\/strong>\uff1a\u82e5\u5e74\u767a\u75c7\u3067\u9032\u884c\u304c\u65e9\u304f\u3066\uff0c\u524d\u5ead\u795e\u7d4c\u9798\u816b\u4ee5\u5916\u306b\u3055\u307e\u3056\u307e\u306a\u816b\u760d\u3092\u767a\u751f\u3057\u3066\u6765\u308b\u30bf\u30a4\u30d7\u3067\u3059<\/li>\n<\/ol>\n<h5>\u795e\u7d4c\u7dda\u7dad\u816b\u75c7\u306f\uff0c\u77e5\u8b58\u306e\u6df1\u3044\u533b\u5e2b\u3068\u76f8\u8ac7\u3057\u306a\u304c\u3089\uff0c\u304d\u3061\u3093\u3068\u7ba1\u7406\u3059\u308c\u3070\uff0c\u5143\u6c17\u306b\u50cd\u3044\u3066\u751f\u304d\u3066\u3044\u304b\u308c\u308b\u75c5\u6c17\u3067\u3059\uff0c\u3042\u304d\u3089\u3081\u306a\u3044<\/h5>\n<h4><strong>\u5168\u9ac4\u819c\u306e\u816b\u760d\u5316\uff0cNF-2\u306e\u9ac4\u819c\u816b\u75c7<\/strong><\/h4>\n<p><a class=\"fancybox\" href=\"\/sawamura\/wp\/wp-content\/uploads\/2015\/07\/meningiomatosis2.jpg\" rel=\"fancybox\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-7872\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2015\/07\/meningiomatosis2-200x200.jpg\" alt=\"meningiomatosis2\" width=\"200\" height=\"200\" \/><\/a><a class=\"fancybox\" href=\"\/sawamura\/wp\/wp-content\/uploads\/2015\/07\/meningiomatosis3.jpg\" rel=\"fancybox\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-7873\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2015\/07\/meningiomatosis3-200x200.jpg\" alt=\"meningiomatosis3\" width=\"200\" height=\"200\" \/><\/a><a class=\"fancybox\" href=\"\/sawamura\/wp\/wp-content\/uploads\/2015\/07\/meningiomatosis1.jpg\" rel=\"fancybox\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-7874\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2015\/07\/meningiomatosis1-200x200.jpg\" alt=\"meningiomatosis1\" width=\"200\" height=\"200\" \/><\/a><\/p>\n<p>\u6975\u3081\u3066\u7a00\u306b\uff0c\u30c6\u30f3\u30c8\u4e0b\u3092\u542b\u3081\u3066\u982d\u84cb\u5185\u306e\u5168\u3066\u306e\u9ac4\u819c\u304c\u540c\u6642\u306b\u816b\u760d\u5316\u3057\u3066\u304d\u307e\u3059(meningiomatosis)\u3002\u521d\u671f\u306b\uff0c\u8133\u5727\u4ea2\u9032\u306b\u3088\u308b\u8996\u795e\u7d4c\u4e73\u982d\u840e\u7e2e\u3067\u4e21\u5074\u306e\u8996\u529b\u304c\u7121\u304f\u306a\u308b\u3068\u3044\u3046\u3088\u3046\u306a\u75c7\u72b6\u304c\u51fa\u307e\u3059\u3002<\/p>\n<h5>\u6587\u732e<\/h5>\n<h4>\u30d6\u30ea\u30ac\u30c1\u30cb\u30d6\u306e\u52b9\u679c<\/h4>\n<\/div>\n<p class=\"heading-title\">Plotkin SR:\u00a0Brigatinib in <i>NF2<\/i>-Related Schwannomatosis with Progressive Tumors. N Engl J Med 2024<br \/>\nNF-2\u60a3\u8005\u3055\u309340\u4eba\u304c\u7d4c\u53e3\u6295\u4e0e\u3092\u53d7\u3051\u307e\u3057\u305f\u3002\u89b3\u5bdf\u671f\u9593\u4e2d\u592e\u502410\u30f6\u6708\u3067\uff0c\u753b\u50cf\u4e0a\u3067\u306a\u3093\u3089\u304b\u306e\u52b9\u679c\u304c\u898b\u3089\u308c\u305f\u306e\u306f10\uff05 radiographic response\u3002\u8074\u795e\u7d4c\u816b\u760d\u3088\u308a\u3082\u9ac4\u819c\u816b\u3084\u305d\u306e\u4ed6\u306e\u795e\u7d4c\u9798\u816b\u306b\u826f\u3044\u53cd\u5fdc\u304c\u898b\u3089\u308c\u305f\u305d\u3046\u3067\u3059\u3002\u8074\u529b\u306e\u6539\u5584\u304c35%\u3067\u307f\u3089\u308c\u305f\u3068\u3044\u3046\u306e\u306f\u6ce8\u76ee\u3067\u3059\u3002\u6295\u4e0e\u671f\u9593\u4e2d\u306f\u5168\u4f53\u7684\u306b\u816b\u760d\u306e\u5897\u5927\u901f\u5ea6\u304c\u5f31\u307e\u3063\u305f\u50be\u5411\u304c\u3042\u3063\u305f\u305d\u3046\u3067\u3059\u3002<\/p>\n<h4>\u810a\u9ac4\u4e0a\u8863\u816b\u306b\u624b\u8853\u9069\u5fdc\u306f\u3042\u308b<\/h4>\n<p>Kalamarides M, et al.: Spinal ependymomas in NF2: a surgical disease?J Neurooncol.\u00a02018<br \/>\n\u82f1\u56fd\u3068\u30d5\u30e9\u30f3\u30b9\u304b\u3089\u306e\u5831\u544a\u3067\u3059\u3002\u7d4c\u904e\u89b3\u5bdf\u3059\u308b\u306827\uff05\u306e\u60a3\u8005\u3055\u3093\u3067\u75c7\u72b6\u304c\u60aa\u5316\u3057\u307e\u3057\u305f\u3002\u810a\u9ac4\u4e0a\u8863\u816b\u306b\u304b\u306a\u308a\u7cbe\u901a\u3057\u305f\u8133\u795e\u7d4c\u5916\u79d1\u533b\u3067\u3042\u308c\u3070\u624b\u8853\u3057\u3066\u75c7\u72b6\u3092\u826f\u304f\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3068\u306e\u7d50\u8ad6\u3067\u3059\u3002\u9032\u884c\u6027\u306b\u5897\u5927\u3059\u308b\u304b\u75c7\u72b6\u304c\u51fa\u3066\u3044\u308b\u4e0a\u8863\u816b\u306f\u6458\u51fa\u3059\u308b\u3079\u304d\u3060\u3068\u8ff0\u3079\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u305f\u3060\u3057\uff0c\u69d8\u3005\u306a\u816b\u760d\u306e\u5897\u5927\u304c\u3042\u308b overwhelming tumor load \u5834\u5408\u306f\uff0c\u30d9\u30d0\u30b7\u30ba\u30de\u30d6\uff08\u30a2\u30d0\u30b9\u30c1\u30f3\uff09\u306e\u6295\u4e0e\u3082\u8003\u616e\u3059\u308b\u3079\u304d\u3060\u305d\u3046\u3067\u3059\u3002<\/p>\n<div class=\"setumei\">\n<h4>\u00a0NF-2\u306e\u591a\u767a\u6027\u9ac4\u819c\u816b<\/h4>\n<p>Goutagny S, et al.: Long-term follow-up of 287 meningiomas in neurofibromatosis type 2 patients: clinical, radiological, and molecular features. Neuro Oncol 14:1090-1096, 2012<br \/>\nNF-2\u306e\u60a3\u8005\u3055\u309374\u4eba\u306b287\u500b\u306e\u9ac4\u819c\u816b\u304c\u767a\u898b\u3055\u308c\uff0c10\u5e74\u304f\u3089\u3044\u306e\u8ffd\u8de1\u8abf\u67fb\u304c\u306a\u3055\u308c\u307e\u3057\u305f\u3002\u9ac4\u819c\u816b\u306e\u9577\u5f84\u5e73\u5747\u306f14mm\u3067\uff0c\u4e00\u5e74\u3042\u305f\u308a1.5 mm\u5927\u304d\u304f\u306a\u308a\u307e\u3057\u305f\u300266%\u306e\u816b\u760d\u306f\u307b\u3068\u3093\u3069\u5897\u5927\u3057\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u305f\u304f\u3055\u3093\u3042\u308b\u9ac4\u819c\u816b\u3067\u307b\u3093\u306e\u4e00\u90e8\u5206\u3060\u3051\u304c\u6025\u306b\u5927\u304d\u304f\u306a\u3063\u305f\u308a\uff0c\u8133\u6d6e\u816b\u3092\u4f34\u3046\u9ac4\u819c\u816b\u3067\u624b\u8853\u304c\u5fc5\u8981\u3068\u306a\u308b\u305d\u3046\u3067\u3059\u3002<br \/>\n\u3053\u306e\u7d50\u679c\u306f\u5f53\u305f\u308a\u524d\u306e\u3053\u3068\u3067\u3059\u304c\uff0c\u9ac4\u819c\u816b\u304c\u591a\u767a\u3059\u308bNF-2\u306e\u60a3\u8005\u3055\u3093\u3067\u306f\uff0c2\u5e74\u306b\u4e00\u56de\u304f\u3089\u3044\u306e\u8133\u306eMRI\u304c\u5fc5\u8981\u3067\u3057\u3087\u3046\u3002\u5168\u90e8\u306e\u9ac4\u819c\u304c\u816b\u760d\u5316\u3059\u308b\u3053\u3068\u304c\u3042\u308b\u306e\u3067\uff0c\u500b\u3005\u306e\u816b\u760d\u306e\u5927\u304d\u3055\u304c\u6e2c\u308c\u306a\u3044\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n<h4>\u30e9\u30d1\u30c1\u30cb\u30d6\u5358\u72ec\u6cbb\u7642\u3067\u816b\u760d\u5897\u5927\u3068\u8074\u529b\u306e\u60aa\u5316\u3092\u4e00\u6642\u7684\u306b\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b<\/h4>\n<p align=\"left\">Karajannis MA, et al.: Phase II trial of lapatinib in adult and pediatric patients with neurofibromatosis type 2 and progressive vestibular schwannomas. Neuro Oncol 14: 1163-1170, 2012<br \/>\nNYU\u304b\u3089\u306e\u5831\u544a\u3067\u3059\u3002\u30e9\u30d1\u30c1\u30cb\u30d6\u306fHER2\u3084EGFR\u306e\u50cd\u304d\u3092\u6291\u5236\u3059\u308b\u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc\u963b\u5bb3\u85ac\uff08\u7d4c\u53e3\u5264\uff09\u3067\u3059\u3002\u9032\u884c\u6027\u306b\u5897\u5927\u3059\u308b\u795e\u7d4c\u81a0\u816b\u3092\u6709\u3059\u308b21\u4eba\u306eNF-2\u60a3\u8005\u3055\u3093\u304c\u30e9\u30d1\u30c1\u30cb\u30d6\u306e\u6cbb\u7642\u3092\u53d7\u3051\u307e\u3057\u305f\u3002\u8a55\u4fa1\u53ef\u80fd\u3067\u3042\u3063\u305f17\u4eba\u306e\u5185\uff0c4\u4eba\u306e\u60a3\u8005\u3055\u3093\u306710%\u4f53\u7a4d\u4ee5\u4e0a\u306e\u816b\u760d\u7e2e\u5c0f\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u8074\u529b\u306e\u8a55\u4fa1\u53ef\u80fd\u306a13\u4eba\u306e\u5185\uff0c4\u4eba\u306710dB\u4ee5\u4e0a\u306e\u8074\u529b\u6539\u5584\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u5897\u60aa\u307e\u3067\u306e\u4e2d\u592e\u5024\u306f14\u30f6\u6708\u3067\u3057\u305f\u3002\u52b9\u679c\u306f\u9650\u5b9a\u7684\u3067\u3059\uff0c\u8457\u8005\u3082\u30a2\u30d0\u30b9\u30c1\u30f3\u306a\u3069\u3068\u306e\u4f75\u7528\u6cbb\u7642\u306e\u65b9\u5411\u3078\u884c\u304f\u3079\u304d\u304b\u3082\u3057\u308c\u306a\u3044\u3068\u7d50\u8ad6\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<h4><span style=\"color: #000080;\"><strong>\u30a2\u30d0\u30b9\u30c1\u30f3\uff08\u30d9\u30d0\u30b7\u30ba\u30de\u30d6\uff09\u306b\u3088\u308b\u816b\u760d\u7e2e\u5c0f\u3068\u8074\u529b\u6539\u5584\u306e\u7a0b\u5ea6<\/strong><\/span><\/h4>\n<ul>\n<li>\u30a2\u30d0\u30b9\u30c1\u30f3\u306b\u3088\u3063\u3066NF-2\u306e\u60a3\u8005\u3055\u3093\u306e\u4e21\u5074\u306e<span style=\"color: #ff0000;\"><strong>\u8074\u795e\u7d4c\u816b\u760d\uff08\u524d\u5ead\u795e\u7d4c\u9798\u816b\uff09\u304c\u5c0f\u3055\u304f\u306a\u308b<\/strong><\/span>\u52b9\u679c\u3084<strong><span style=\"color: #ff0000;\">\u8074\u529b\u304c\u6539\u5584\u3059\u308b<\/span><\/strong>\u3068\u3044\u3046\u52b9\u679c\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059<\/li>\n<li>\u78ba\u304b\u306b\u30a2\u30d0\u30b9\u30c1\u30f3\u306f\uff0c\u534a\u657050%\u304f\u3089\u3044\u306e\u60a3\u8005\u3055\u3093\u3067\uff0c\u52e2\u3044\u3088\u304f\u5897\u5927\u3059\u308b\u8074\u795e\u7d4c\u816b\u760d\u306e\u5897\u5927\u3092\u6b62\u3081\u3066\uff0c\u4e00\u90e8\u306e\u60a3\u8005\u3055\u3093\u3067\u4e00\u5b9a\u671f\u9593\u306f\u8074\u529b\u3092\u5b88\u308b\u52b9\u679c\u3092\u6301\u3063\u3066\u3044\u307e\u3059<\/li>\n<li>\u3067\u3082VEGF\u306b\u5bfe\u3059\u308b\u5358\u306a\u308b\u6297\u4f53\u306a\u306e\u3067\uff0c\u7406\u8ad6\u7684\u306b\u3082<span style=\"color: #ff0000;\"><strong>\u305d\u306e\u52b9\u679c\u306f\u4e00\u6642\u7684\u3067\u3059<\/strong><\/span><\/li>\n<li>\u8074\u795e\u7d4c\u816b\u760d\u304c\u6cbb\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3057\u30a2\u30d0\u30b9\u30c1\u30f3\u3092\u6b62\u3081\u308c\u3070\u307e\u305f\u816b\u760d\u306f\u5897\u5927\u3057\u307e\u3059<\/li>\n<li>\u65e5\u672c\u3067\u306f\u4fdd\u967a\u8a3a\u7642\u3067\u4f7f\u3048\u306a\u3044\u306e\u3067\u6cbb\u7642\u8cbb\u306f\u81ea\u5df1\u8ca0\u62c5\u3068\u306a\u308a\uff0c1\u5e741000\u4e07\u5186\u5f31\u306e\u5b9f\u8cbb\u304c\u5fc5\u8981\u3068\u306a\u308b\u3067\u3057\u3087\u3046<\/li>\n<\/ul>\n<div>\n<hr \/>\n<\/div>\n<div>\n<p align=\"left\">Alanin MC et al.: The effect of bevacizumab on vestibular schwannoma tumour size and hearing in patients with neurofibromatosis type 2. Eur Arch Otorhinolaryngol. 2014, Nov 25 [Epub]<br \/>\n\u30a2\u30d0\u30b9\u30c1\u30f3\u304c\u6295\u4e0e\u3055\u308c\u305f12\u4eba\u306e\u3046\u3061\uff0c6\u4eba\u3067\u816b\u760d\u306e\u7e2e\u5c0f\u304c\u307f\u3089\u308c\uff0c3\u4eba\u306e\u60a3\u8005\u3055\u3093\u3067\u8074\u529b\u306e\u6539\u5584\u304c\u3048\u3089\u308c\u307e\u3057\u305f\u3002\u304a\u305d\u3089\u304f\u30a2\u30d0\u30b9\u30c1\u30f3\u306b\u95a2\u9023\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u8133\u5185\u51fa\u8840\u30671\u4eba\u306e\u60a3\u8005\u3055\u3093\u304c\u6b7b\u4ea1\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/div>\n<div>\n<hr \/>\n<\/div>\n<p>Plotkin SR, et al.: Bevacizumab for progressive vestibular schwannoma in neurofibromatosis type 2: a retrospective review of 31 patients. Otol Neurotol 33: 1046-1052, 2012<br \/>\n31\u4eba\u306e\u60a3\u8005\u3055\u3093\u306b\u30a2\u30d0\u30b9\u30c1\u30f3\u304c\u6295\u4e0e\u3055\u308c\u307e\u3057\u305f\u3002\u6295\u4e0e\u671f\u9593\u4e2d\u592e\u5024\u306f14\u30f6\u6708\uff086\u30f6\u6708\u304b\u308941\u30f6\u6708\uff09\u3067\u3059\u3002\u6295\u4e0e\u958b\u59cb\u304b\u3089\uff13\u30f6\u6708\u307b\u3069\u3067\u52b9\u679c\u304c\u307f\u3089\u308c\u307e\u3057\u305f\u3002\u9032\u884c\u6027\u306b\u5897\u5927\u3059\u308b\u524d\u5ead\u795e\u7d4c\u9798\u816b\u306e50%\u4ee5\u4e0a\u306b\u52b9\u679c\u304c\u3042\u308b\u3068\u7d50\u8ad6\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u6cbb\u7642\u958b\u59cb3\u5e74\u306e\u6642\u70b9\u3067\uff0c61\uff05\u306e\u60a3\u8005\u3055\u3093\u3067\u8074\u529b\u304c\u6e29\u5b58\u3055\u308c\u308b\u304b\u6539\u5584\u3057\u3066\u3044\u3066\uff0c54%\u3067\u816b\u760d\u306e\u5897\u5927\u50be\u5411\u304c\u505c\u6b62\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u6700\u9577\u306741\u30f6\u6708\uff0c\u7d04\uff14\u5e74\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u304c\uff0c\u3053\u306e\u5831\u544a\u3092\u3057\u305f\u533b\u5e2b\u306f\u30a2\u30d0\u30b9\u30c1\u30f3\u306e\u52b9\u679c\u304c\u6c38\u7d9a\u7684\u3067\u306f\u306a\u3044\u4e8b\u3092\u77e5\u3063\u3066\u3044\u308b\u304b\u3089\u9577\u671f\u6295\u4e0e\u3092\u3057\u305f\u306e\u3067\u3059\u30022015\u5e74\u6642\u70b9\u3067\uff0c\u65e5\u672c\u3067\u306fNF-2\u306e\u60a3\u8005\u3055\u3093\u306b\u73fe\u5b9f\u7684\u306b\u4f7f\u7528\u3067\u304d\u308b\u85ac\u5264\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<hr \/>\n<p><span style=\"color: #000080;\"><strong>Plotkin SR, et al.: Hearing improvement after bevacizumab in patients with neurofibromatosis type 2. N Engl J Med 361: 358-367, 2009<\/strong><\/span><br \/>\nMGH\u304b\u3089\u306e\u5831\u544a\u3067\u3059\u3002VEGF\u304c\u524d\u5ead\u795e\u7d4c\u9798\u816b\u306e\u8840\u7ba1\u5897\u6b96\u3068\u6210\u9577\u3092\u3046\u306a\u304c\u3059\u306e\u3067\uff0c\u6297VEGF\u6297\u4f53\u3067\u3042\u308b\u30a2\u30d0\u30b9\u30c1\u30f3\u304c\uff0c10\u4eba\u306e\u60a3\u8005\u3055\u3093\u306b\u6295\u4e0e\u3055\u308c\u307e\u3057\u305f\u300210\u4eba\u306e\u816b\u760d\u306f\u5e74\u9593\u306762%\u306e\u4f53\u7a4d\u5897\u52a0\u304c\u3042\u308a\u307e\u305f\uff0c\u524d\u5ead\u795e\u7d4c\u9798\u816b\u3068\u3057\u3066\u306f\u8457\u3057\u3044\u5897\u5927\u50be\u5411\u3092\u6709\u3059\u308b\u3082\u306e\u3067\u3057\u305f\u3002\u30a2\u30d0\u30b9\u30c1\u30f3\u306e\u6295\u4e0e\u306b\u3088\u308a\uff0c\uff19\u4eba\u3067\u816b\u760d\u7e2e\u5c0f\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u30026\u4eba\u306e\u60a3\u8005\u3055\u3093\u3067\u306f\u816b\u760d\u4f53\u7a4d\u304c20%\u4ee5\u4e0a\u6e1b\u308a\u307e\u3057\u305f\u3002\uff14\u4eba\u306e\u60a3\u8005\u3055\u3093\u3067\u816b\u760d\u306e\u7e2e\u5c0f\u309211\u30f6\u6708\u304b\u308916\u30f6\u6708\u7dad\u6301\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3057\u305f\u30027\u4eba\u306e\u60a3\u8005\u3055\u3093\u3067\u8074\u529b\u304c\u6e2c\u5b9a\u3055\u308c\uff0c\u305d\u306e\u5185\u306e4\u4eba\u3067\u8074\u529b\u306e\u6539\u5584\u304c\u3042\u308a\u307e\u3057\u305f\u30022\u4eba\u3067\u8074\u529b\u306f\u5909\u308f\u3089\u305a\uff0c1\u4eba\u3067\u7d99\u7d9a\u7684\u8074\u529b\u4f4e\u4e0b\u304c\u751f\u3058\u307e\u3057\u305f\u3002<\/p>\n<p style=\"text-align: center;\"><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/owlnf.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-2084\" title=\"owlnf\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/owlnf.jpg\" alt=\"\" width=\"600\" height=\"865\" \/><\/a><\/p>\n<h4><strong>\u307e\u3081\u77e5\u8b58\u3000 NF-2\u306e\u539f\u56e0<\/strong><\/h4>\n<p>\u795e\u7d4c\u7dda\u7dad\u816b\u75c72\u578b\u306e\u8cac\u4efb\u907a\u4f1d\u5b50\u306f\u7b2c22\u67d3\u8272\u4f53\u9577\u8155 (22q12)\u306b\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u304c \u4f5c\u308a\u51fa\u3059\u86cb\u767d\u8cea\u306f\u30de\u30fc\u30ea\u30f3 merlin\uff08\u307e\u305f\u306f schwannomin\uff09\u3068\u547c\u3070\u308c\u3066\u3044\u307e\u3059\u3002\u30de\u30fc\u30ea\u30f3\u306f\u816b\u760d\u306e\u767a\u751f\u3092\u6291\u3048\u308b\u50cd\u304d\u304c\u3042\u308b\u306e\u3067\u3059\u304c\uff0c\u30de\u30fc\u30ea\u30f3\u86cb\u767d\u306e\u50cd\u304d\u306b\u7570\u5e38\u304c\u3042\u308b\u3068\u816b\u760d\u304c\u767a\u751f\u3057\u3066\u3057\u307e\u3044\u307e\u3059\u3002<\/p>\n<h4>\u795e\u7d4c\u9798\u816b\u75c7 schwannomatosis<\/h4>\n<ul>\n<li>\u305f\u304f\u3055\u3093\u306e\u795e\u7d4c\u9798\u816b\u304c\u8133\u795e\u7d4c\u3068\u810a\u9ac4\u795e\u7d4c\u306b\u3067\u304d\u308b\u306e\u3067\u3059\u304c\uff0cNF-2\u3068\u306f\u9055\u3044\u307e\u3059<\/li>\n<li>germ-line NF-2 gene\u306b\u5909\u7570\u304c\u3042\u308a\u307e\u305b\u3093\u304cNF-2\u306e\u4e0d\u6d3b\u5316\u306f\u307f\u3089\u308c\u307e\u3059<\/li>\n<li>\u534a\u6570\u304f\u3089\u3044\u306bSMARCB1 or LZTR1\u816b\u760d\u6291\u5236\u907a\u4f1d\u5b50\u306b\u5909\u7570\u304c\u3042\u308a\u307e\u3059<\/li>\n<li>\u307e\u308c\u306b\u9ac4\u819c\u816b\u3092\u5408\u4f75\u3057\u307e\u3059<\/li>\n<\/ul>\n<h4><span style=\"color: #003366;\"><strong>NF-2\u3067\u8074\u529b\u3092\u5b88\u308b\u305f\u3081\u306b\u65e9\u3081\u306b\u624b\u8853\u3092\u3059\u308b\u304b\uff1f<\/strong><\/span><\/h4>\n<p>\u53e4\u304f\u304b\u3089\u3042\u308b\u8b70\u8ad6\u3067\u3059\u3002\u8074\u529b\u304c\u826f\u597d\u3067\u8074\u795e\u7d4c\u816b\u760d\u304c\u5c0f\u3055\u3044\u3046\u3061\u306b\u624b\u8853\u3057\u3066\u6458\u51fa\u3059\u308c\u3070\uff0cNF-2\u306e\u60a3\u8005\u3055\u3093\u3067\u3082\u8074\u529b\u3092\u4fdd\u3063\u305f\u307e\u307e\u751f\u5b58\u3057\u3066\u884c\u304f\u3053\u3068\u304c\u3067\u304d\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u3044\u3046\u5358\u7d14\u306a\u767a\u60f3\u3067\u3059\u30022015\u5e74\u306b\u3082\u30dd\u30fc\u30e9\u30f3\u30c9\u306e\u8ad6\u6587 (Nowak A, et al.) \u306b\u5c0f\u3055\u306a\u524d\u5ead\u795e\u7d4c\u9798\u816b\u306f\u65e9\u3081\u306e\u5916\u79d1\u7684\u5e72\u6e09\u304c\u826f\u3044\u3068\u66f8\u304b\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u3067\u3082\u826f\u597d\u306a\u8074\u529b\u304c\u3042\u308b22\u4f8b\u306e\u624b\u8853\u306e\u7d50\u679c\uff0c19\u4f8b\u3067\u8074\u529b\u304c\u7121\u304f\u306a\u3063\u305f\u3068\u306e\u6cbb\u7642\u6210\u7e3e\u3067\u3059?<br \/>\n\u4e21\u8033\u3067\u5f90\u3005\u306b\u8074\u529b\u4f4e\u4e0b\u304c\u751f\u3058\u308b\u306e\u3067\u60a3\u8005\u3055\u3093\u306f\u4e0d\u5b89\u3067\u3059\u3002\u65e9\u3081\u306b\u6cbb\u7642\u3057\u305f\u65b9\u304c\u3044\u3044\u3068\u601d\u3046\u306e\u306f\u81ea\u7136\u306a\u3053\u3068\u3067\u3059\u3002\u3067\u3082\u5b9f\u969b\u306b\u306f\uff0c\u624b\u8853\u3067\u8074\u529b\u3092\u5931\u3046\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u3002NF-2\u4ee5\u5916\u306e\u8074\u795e\u7d4c\u816b\u760d\u306e\u8074\u529b\u6e29\u5b58\u5272\u5408\u3088\u308a\uff0cNF-2\u306e\u60a3\u8005\u3055\u3093\u3067\u306e\u624b\u8853\u6210\u7e3e\u306e\u307b\u3046\u304c\u304b\u306a\u308a\u60aa\u3044\u3068\u3044\u3046\u3053\u3068\u3082\u8a8d\u8b58\u3057\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093\u3002<\/p>\n<h4>\u30ac\u30f3\u30de\u30ca\u30a4\u30d5\u6cbb\u7642<\/h4>\n<p>Sun S, Liu A: Long-term follow-up studies of Gamma Knife surgery for patients with neurofibromatosis Type 2. J Neurosurg 21: Suppl:143-149, 2014<br \/>\n\u5317\u4eac\u306e\u5929\u58c7\u75c5\u9662\u304b\u3089\u306e\u5831\u544a\u3067\u3059\u300246\u4eba\u306eNF-2\u306e\u60a3\u8005\u3055\u3093\u304c\u30ac\u30f3\u30de\u30ca\u30a4\u30d5\u3067\u6cbb\u7642\u3055\u308c\u30665\u5e74\u4ee5\u4e0a\u306e\u7d4c\u904e\u89b3\u5bdf\u3092\u53d7\u3051\u307e\u3057\u305f\u3002\u816b\u760d\u4f53\u7a4d\u5e73\u5747\u306f5.1cm(3) \uff0c\u8fba\u7e01\u7dda\u91cf\u5e73\u5747 12.9Gy\uff0c\u6700\u5927\u7dda\u91cf\u5e73\u5747\u306f27.3Gy\u3067\u3059\u3002\u524d\u5ead\u795e\u7d4c\u9798\u816b73\u4f8b\u306e\u3046\u3061\u816b\u760d\u5897\u5927\u304c12\u4f8b (16%)\u3067\u751f\u3058\u307e\u3057\u305f\u3002\u3053\u306e\u5c40\u6240\u5236\u5fa1\u7387 84% \u3068\u3044\u3046\u6570\u5b57\u306f\uff0c\u4e00\u822c\u7684\u306a\u5b64\u767a\u6027\u306e\u524d\u5ead\u795e\u7d4c\u9798\u816b 95% \u3088\u308a\u3082\u304b\u306a\u308a\u60aa\u3044\u6570\u5b57\u3068\u8a00\u3048\u307e\u3059\u3002\u8074\u529b\u6e29\u5b58\u5272\u5408actuarial rate\u306f10\u5e74\u306744%\uff0c15\u5e74\u306717%\u3067\u3057\u305f\u3002\u6cbb\u7642\u306b\u3088\u308b\u8074\u529b\u4f4e\u4e0b\u306e\u30ea\u30b9\u30af\u306f\u9ad8\u3044\u3068\u7d50\u8ad6\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<h4>\u5b9a\u4f4d\u653e\u5c04\u7dda\u5916\u79d1\u6cbb\u7642<\/h4>\n<p>Subach BR, et al.: Stereotactic radiosurgery in the management of acoustic neuromas associated with neurofibromatosis Type 2. J Neurosurg 119 Suppl:815-822, 2013<br \/>\n\u30d4\u30c3\u30c4\u30d0\u30fc\u30b0\u304b\u3089\u306e\u5831\u544a\u3067\u3059\u300230\u4f8b\u306eNF-2\u306e\u60a3\u8005\u3055\u3093\u304c\u6cbb\u7642\u3092\u53d7\u3051\u307e\u3057\u305f\u3002\u816b\u760d\u4f53\u7a4d\u5e73\u5747\u306f4.8cm(3) \uff0c\u8fba\u7e01\u7dda\u91cf\u5e73\u5747 15Gy\u3067\u3057\u305f\u3002\u7d4c\u904e\u89b3\u5bdf\u671f\u9593\u4e2d\u592e\u502436\u30f6\u6708\u3067\u306e\u816b\u760d\u5236\u5fa1\u5272\u5408\u306f98%\u00a0(44\/45)\u3067\u3057\u305f\u3002\u6709\u7528\u8074\u529b (G-R Class I or II)\u306f14\u4eba\u4e2d\u306e6\u4eba(43%)\u3067\u6e29\u5b58\u3055\u308c\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002\u307e\u305f1992\u5e74\u4ee5\u964d\u306b\u304b\u304e\u308c\u307067\uff05\u306e\u6e29\u5b58\u7387\u3067\u3057\u305f\u3002<br \/>\n\u300c\u89e3\u8aac\u300d\u3042\u307e\u308a\u306b\u3082\u826f\u3044\u6210\u7e3e\u3067\u3059\u3002\u7d4c\u904e\u89b3\u5bdf\u671f\u9593\uff08\u4e2d\u592e\u50243\u5e74\uff09\u304c\u304b\u306a\u308a\u77ed\u3044\u306e\u3067\u3053\u308c\u309210\u5e74\u306b\u5ef6\u3070\u3059\u3068\u7d50\u679c\u306f\u305a\u3063\u3068\u60aa\u304f\u306a\u308b\u3068\u601d\u308f\u308c\u307e\u3059\u3002<\/p>\n<h4>NF-2\u306e\u85ac\u7269\u6cbb\u7642\u306e\u65b9\u5411\u6027<\/h4>\n<p>bevacizumab, suntinib malate, lapatinib\u306a\u3069\u304c\uff0cplexiform neurofibroma, multiple meningioma, spinal ependymoma, bilateral acoustic tumors\u306a\u3069\u306b\u4f7f\u7528\u3055\u308c\u3066\uff0c\u5c11\u6570\u4f8b\u306e\u5831\u544a\u304c\u76f8\u6b21\u3044\u3067\u3044\u307e\u3059\u3002\u3067\u30822015\u5e74\u6642\u70b9\u3067\u306f\uff0c\u52b9\u679c\u306f\u4e00\u904e\u6027\u3067\u4fdd\u967a\u8a3a\u7642\u3082\u3067\u304d\u305a\u6cbb\u7642\u8cbb\u304c\u3068\u3066\u3082\u9ad8\u984d\u3067\u3059\u3002\u73fe\u5b9f\u7684\u306b\u304a\u52e7\u3081\u3067\u304d\u308b\u65b0\u85ac\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<h4>NF-2\u306e\u60a3\u8005\u3055\u3093\u306e\u751f\u5b58\u306e\u8cea\u3000QOL<\/h4>\n<p>NF-2\u306e\u60a3\u8005\u3055\u3093\u306f\u807e\uff08\u4e21\u8033\u304c\u805e\u3053\u3048\u306a\u3044\uff09\uff0c\u9854\u9762\u795e\u7d4c\u9ebb\u75fa\uff0c\u6b69\u884c\u304c\u4e0d\u5b89\u5b9a\uff0c\u4f53\u306e\u75db\u307f\u306a\u3069\u8eab\u4f53\u9762\u3067\u306e\u969c\u5bb3\u3092\u304b\u304b\u3048\u308b\u305f\u3081\u306bQOL\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u304d\u307e\u3059\u3002\u3067\u3082\uff0c\u3082\u3063\u3068QOL\u3092\u843d\u3068\u3057\u3066\u3044\u308b\u306e\u306f\uff0c\u75c5\u6c17\u306b\u5bfe\u3059\u308b\u7cbe\u795e\u7684\u306a\u30b9\u30c8\u30ec\u30b9\u3067\u3059\u3002\u5c06\u6765\u3078\u306e\u4e0d\u5b89\u306b\u52a0\u3048\u3066\uff0c\u65e5\u5e38\u7684\u306a\u500b\u4eba\u3042\u308b\u3044\u306f\u5bb6\u5ead\u751f\u6d3b\uff0c\u751f\u6d3b\u8cbb\u3078\u306e\u30b9\u30c8\u30ec\u30b9\u304c\u3042\u308a\u307e\u3059\u3002\u516c\u7684\u306a\u7cbe\u795e\u9762\u3067\u306e\u5065\u5eb7\u7ba1\u7406\u3068\u751f\u6d3b\u88dc\u52a9\u304c\u6c42\u3081\u3089\u308c\u307e\u3059\u3002\u533b\u7642\u8cbb\u306e\u88dc\u52a9\u306f\u3042\u308b\u306e\u3067\u3059\u304c\uff0c\u539a\u52b4\u7701\u306f\u305d\u3093\u306a\u3068\u3053\u308d\u307e\u3067\u9762\u5012\u898b\u3066\u4e0b\u3055\u3089\u306a\u3044\u306e\u3067\uff0c\u62c5\u5f53\u3059\u308b\u533b\u5e2b\u304c\u60a3\u8005\u3055\u3093\u306e\u5fc3\u3092\u652f\u3048\u308b\u533b\u7642\u3092\u3059\u308b\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002<\/p>\n<h4>NF-2\u306e\u76ee\u306e\u75c7\u72b6<\/h4>\n<p>\u304b\u306a\u308a\u591a\u304f\u306e\u60a3\u8005\u3055\u3093\u304c<span style=\"color: #000080;\"><strong>\u82e5\u5e74\u6027\u767d\u5185\u969c<\/strong><\/span> subcapsular cataract \u306b\u306a\u308a\u307e\u3059\u304b\u3089\uff0c\u773c\u79d1\u3078\u306e\u53d7\u8a3a\u306f\u6b20\u304b\u305b\u307e\u305b\u3093<\/p>\n<h4><span style=\"color: #000080;\"><strong>ABI \u8074\u6027\u8133\u5e79\u30a4\u30f3\u30d7\u30e9\u30f3\u30c8<\/strong><\/span><\/h4>\n<p>\u3053\u306e\u6280\u8853\u304c\u5c0e\u5165\u3055\u308c\u3066\u304b\u3089\u306f20\u5e74\u4ee5\u4e0a\u305f\u3061\uff0c\u56fd\u969b\u7684\u89b3\u70b9\u304b\u3089NF-2\u306e\u60a3\u8005\u3055\u3093\u3078\u306e\u624b\u8853\u9069\u5fdc\u306f\u8a8d\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\uff0c\u4fdd\u967a\u8a3a\u7642\u3067\u306f\u306a\u3044\u306e\u3067\u6570\u767e\u4e07\u5186\u306e\u304a\u91d1\u3068\u958b\u982d\u624b\u8853\u304c\u5fc5\u8981\u3068\u306a\u308b\u6cbb\u7642\u6cd5\u3067\u3059\u3002\u6cbb\u7642\u5f8c\u3082\u9577\u3044\u30ea\u30cf\u30d3\u30ea\u304c\u5fc5\u8981\u3067\u3059\u3057\uff0c\u6210\u529f\u7387\u304c\u9ad8\u304f\u306f\u306a\u3044\u306e\u3067\u4e00\u822c\u5316\u3057\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n<hr \/>\n<p>Behr R, et al.: New outcomes with auditory brainstem implants in NF2 patients. Otol Neurotol 35:1844-1851, 2014<br \/>\n\u65e5\u672c\u3092\u542b\u3080\u591a\u56fd\u306e\u6210\u7e3e\u3092\u307e\u3068\u3081\u305f\u3082\u306e\u3067\u3059\u3002\u524d\u5ead\u795e\u7d4c\u9798\u816b\u6458\u51fa\u5f8c\u306bABI\u304c\u57cb\u3081\u8fbc\u307e\u308c\u307e\u3057\u305f\u300284\u540d\u306eNF-2\u306e\u60a3\u8005\u3055\u3093\u306e\u3046\u306126\u4f8b(31%)\u306730% speech recognition\uff08\u9759\u304b\u306a\u3068\u3053\u308d\u3067\u805e\u304d\u5206\u3051\u3089\u308c\u308b\uff09\u304c\u5f97\u3089\u308c\u307e\u3057\u305f\u3002\u6210\u7e3e\u306b\u6700\u3082\u5f71\u97ff\u3057\u305f\u306e\u306f\u816b\u760d\u5727\u8feb\u3084\u624b\u8853\u306b\u3088\u308b\u8133\u5e79\u90e8\u306e\u640d\u50b7 brainstem trauma\uff08\u6a5f\u80fd\u4f4e\u4e0b\uff09\u3067\u3042\u3063\u305f\u305d\u3046\u3067\u3059\u30023\u5272\u304f\u3089\u3044\u306e\u6210\u529f\u5272\u5408\u3068\u6349\u3048\u3066\u3082\u3044\u3044\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n<\/div>\n<div class=\"setumei\">\n<h4>\u00a0\u6587\u732e<\/h4>\n<ul>\n<li>Behr R, et al.: New outcomes with auditory brainstem implants in NF2 patients. Otol Neurotol 35:1844-1851, 2014<\/li>\n<li>Cosetti MK, et al.: Quality of Life (QoL) Assessment in Patients with Neurofibromatosis Type 2 (NF2). Otolaryngol Head Neck Surg, 2015<\/li>\n<li>Karajannis MA, et al.: Phase II trial of lapatinib in adult and pediatric patients with neurofibromatosis type 2 and progressive vestibular schwannomas. Neuro Oncol 14: 1163-1170, 2012<\/li>\n<li>Plotkin SR, et al.: Hearing improvement after bevacizumab in patients with neurofibromatosis type 2. N Engl J Med 361: 358-367, 2009<\/li>\n<li>Plotkin SR, et al.: Bevacizumab for progressive vestibular schwannoma in neurofibromatosis type 2: a retrospective review of 31 patients. Otol Neurotol 33: 1046-1052, 2012<\/li>\n<li>Ruggieri M, et al.: Earliest clinical manifestations and natural history of neurofibromatosis type 2 (NF2) in childhood: a study of 24 patients. Neuropediatrics 36:21-34, 2005<\/li>\n<li>Subach BR, et al.: Stereotactic radiosurgery in the management of acoustic neuromas associated with neurofibromatosis Type 2. J Neurosurg 119 Suppl: 815-822, 2013<\/li>\n<li>Sun S, Liu A: Long-term follow-up studies of Gamma Knife surgery for patients with neurofibromatosis Type 2. J Neurosurg 21: Suppl:143-149, 2014<\/li>\n<li>VargasWS, et al.: Incidental parenchymal magnetic resonance imaging findings in the brains of patients with neurofibromatosis type 2. Neuroimage Clin, 2014<\/li>\n<\/ul>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>neurofibromatosis \u795e\u7d4c\u7dda\u7dad\u816b\u75c7 \u89aa\u304b\u3089\u5b50\u306b\u907a\u4f1d\uff08\u5e38\u67d3\u8272\u4f53\u512a\u6027\u907a\u4f1d\u75be\u60a3\uff09\u3059\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u304c\uff0c\u534a\u5206\u4ee5\u4e0a\u306e\u60a3\u8005\u3055\u3093\u306f\u907a\u4f1d\u3067\u306f\u3042\u308a\u307e\u305b\u3093 3\u3064\u306e\u578b\u304c\u3042\u308a\uff0c1\u578b\u304c96\uff05\uff0c2\u578b\u304c3\uff05\uff0cschwannomatosi [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-8097","post","type-post","status-publish","format-standard","hentry","category-braintumors"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/8097","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/comments?post=8097"}],"version-history":[{"count":18,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/8097\/revisions"}],"predecessor-version":[{"id":22760,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/8097\/revisions\/22760"}],"wp:attachment":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/media?parent=8097"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/categories?post=8097"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/tags?post=8097"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}